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Allergy, Asthma & Immunology Research

Hélène Sénéchal, Sanaz Keykhosravi, Rémy Couderc, Marie Ange Selva, Youcef Shahali, Tomoyasu Aizawa, Jean Marc Busnel, Rihane Arif, Inna Mercier, Nhan Pham-Thi, Denis André Charpin, Pascal Poncet
A pollen/food-associated syndrome (PFAS) has been described between peach and cypress pollen. Cross-reactive allergens were characterized which belong to the Gibberellin-regulated protein (GRP) family, BP14 in cypress pollen and Pru p 7 in peach. GRP are small cationic protein with anti-microbial properties. A patient suffering from a peach/cypress syndrome was explored clinically and biologically using 2 types of immunoglobulin E (IgE) multiarray microchip, immunoblots and a basophil activation test to assess the clinical relevance of various extracts and purified allergens from fruits or cypress pollen...
January 2019: Allergy, Asthma & Immunology Research
Bhakkawarat Kulwanich, Sasipa Thanyaratsrisakul, Orathai Jirapongsananuruk, Belinda J Hales, Wayne R Thomas, Surapon Piboonpocanun
PURPOSE: Hypoallergenic recombinant Der p 2 has been produced by various genetic manipulations, but mutation of a naturally polymorphic amino acid residue known to affect IgE binding has not been studied. This study aimed to determine the effect of a point mutation (S47W) of residue 47 of Der p 2 on its structure and immunoglobulin (Ig) E binding. Its ability to induce pro-inflammatory responses and to induce blocking IgG antibody was also determined. METHODS: S47 of recombinant Der p 2...
January 2019: Allergy, Asthma & Immunology Research
Shan Deng, Jia Yin
PURPOSE: Little is known about the importance of lipid transfer protein (LTP) sensitization in China. In this study, we investigated the relationship between LTP sensitization and the severity of clinical symptoms in a population of patients with mugwort pollen-related food allergy. METHODS: Food-induced symptoms were evaluated in 148 patients with mugwort pollen allergy by a standardized questionnaire. Specific immunoglobulin E (IgE) to Art v 1, Art v 3, Pru p 3, Ara h 9 and Cor a 8 were quantified by ImmunoCAP...
January 2019: Allergy, Asthma & Immunology Research
Byung Keun Kim, Hyun Seung Lee, Kyoung Hee Sohn, Suh Young Lee, Sang Heon Cho, Heung Woo Park
BACKGROUND: Elderly asthma (EA) is increasing, but the pathogenesis is unclear. This study aimed to identify EA-related biological pathways by analyzing genome-wide gene expression profiles in sputum cells. METHODS: A total of 3,156 gene probes with significantly differential expressions between EA and healthy elderly controls were used for a hierarchical clustering of genes to identify gene clusters. Gene set enrichment analysis provided biological information, with replication from Gene Expression Omnibus expression profiles...
January 2019: Allergy, Asthma & Immunology Research
Ho Yeon Jung, Sunmin Park, Beomsu Shin, Ji Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Won Yeon Lee, Suk Joong Yong, Sang Ha Kim
PURPOSE: Although there have been reported cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis drugs, there has been no research to examine its prevalence. This study assessed the prevalence and clinical characteristics of DRESS syndrome caused by antituberculosis drugs. METHODS: The electronic medical records of a cohort consisting of adult patients diagnosed with tuberculosis between July 2006 and June 2010 were reviewed and retrospectively inspected...
January 2019: Allergy, Asthma & Immunology Research
Bastsetseg Ulambayar, So Hee Lee, Eun Mi Yang, Young Min Ye, Hae Sim Park
PURPOSE: Asthma in the elderly has different clinical features including more severe phenotypes with higher comorbidities. Epithelial cells are known to initiate innate/adaptive immune responses in asthmatic airways. We investigated clinical features and epithelial derived cytokine levels in elderly asthmatics compared to non-elderly asthmatics in a cross-sectional cohort of adult asthmatics in order to further understand its pathogenic mechanisms. METHODS: A total of 1,452 adult asthmatics were enrolled from a single tertiary hospital and were classified into 2 groups: 234 elderly (≥ 60 years at initial diagnosis) and 1,218 non-elderly (< 60 years at initial diagnosis) asthmatics...
January 2019: Allergy, Asthma & Immunology Research
Yanran Huang, Chengshuo Wang, Feifei Cao, Yan Zhao, Hongfei Lou, Luo Zhang
PURPOSE: Data comparing the long-term efficacy and safety of subcutaneous immunotherapy (SCIT) using house dust mite (HDM) in children and adults with allergic rhinitis (AR) are limited. This study aimed to compare the long-term effects of HDM-SCIT in a cohort of Chinese pediatric and adult patients with AR. METHODS: A total of 124 pediatric and adult AR patients received HDM-SCIT for 3 years, with 118 patients being followed-up for 2 years. Prior to treatment (baseline), at the end of the 3-year treatment periods (third year) and 2 years after the discontinuation of treatment (fifth year), all patients were evaluated for total nasal symptom scores (TNSS), daily medication score (DMS), total combined score (TCS; symptoms [nasal + ocular] + DMS) and quality of life (QoL)...
January 2019: Allergy, Asthma & Immunology Research
Ji Ho Lee, Yoon Ju Bae, So Hee Lee, Su Chin Kim, Hyun Young Lee, Ga Young Ban, Yoo Seob Shin, Hae Sim Park, Juergen Kratzsch, Young Min Ye
PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and responsiveness to changes in CU for the Korean version of the UCT (K-UCT) and its relation with salivary cortisol and cortisone levels. METHODS: Linguistic adaptation of the UCT into Korean was conducted...
January 2019: Allergy, Asthma & Immunology Research
Min Hye Kim, Sang Heon Kim, So Young Park, Ga Young Ban, Joo Hee Kim, Jae Woo Jung, Ji Yong Moon, Woo Jung Song, Hyouk Soo Kwon, Jae Woo Kwon, Jae Hyun Lee, Hye Ryun Kang, Jong Sook Park, Tae Bum Kim, Heung Woo Park, Kwang Ha Yoo, Yeon Mok Oh, Young Il Koh, An Soo Jang, Byung Jae Lee, Young Joo Cho, Sang Heon Cho, Hae Sim Park, Choon Sik Park, Ho Joo Yoon, You Sook Cho
PURPOSE: Although mild to moderate asthma is much more common, the morbidity and mortality of severe asthma are much higher. This study was performed to identify and analyze the clinical characteristics of severe asthma in Korea. METHODS: We registered patients with severe refractory asthma into the Severe Asthma Registry supported by the Severe Asthma Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology. Patients were enrolled since 2010 from the 15 university hospitals nationwide in Korea...
January 2019: Allergy, Asthma & Immunology Research
Jorge Sánchez, Andres Sánchez, Ricardo Cardona
PURPOSE: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if these IgE autoantibodies can trigger urticaria is still a matter of study. The aim of this study was to investigate the relationship between concomitant IgE autoantibodies against thyroid antigens in CSU. METHODS: Patients with CSU, healthy subjects and patients with autoimmune thyroid disease (ATD) were recruited...
January 2019: Allergy, Asthma & Immunology Research
Yong Ju Lee, Takao Fujisawa, Chang Keun Kim
Wheezing is one of the characteristic symptoms of asthma, but all preschool children with wheezing are not diagnosed with asthma. Preschool children are not cooperative enough to participate in spirometry and invasive tests. Thus, there is no conventional method to diagnose asthma in preschool children. We reviewed studies on non-invasive biomarkers for assessing asthma in preschool children. Specimens that can be easily obtained by non-invasive methods are blood, exhaled breath and urine. Eosinophils, eosinophil cationic protein and eosinophil-derived neurotoxin (EDN) in blood are helpful in evaluating eosinophilic inflammation of the airways...
January 2019: Allergy, Asthma & Immunology Research
Elizabeth Huiwen Tham, Donald Ym Leung
The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for triggering the progression from the skin barrier dysfunction seen in AD to epicutaneous sensitization, food allergy and allergic airway disorders...
January 2019: Allergy, Asthma & Immunology Research
Bastsetseg Ulambayar, Hae Sim Park
No abstract text is available yet for this article.
January 2019: Allergy, Asthma & Immunology Research
Luciana Souza De Aragão-França, Viviane Costa Junqueira Rocha, Andre Cronemberger-Andrade, Fábio Henrique Brasil Da Costa, Juliana Fraga Vasconcelos, Daniel Abensur Athanazio, Daniela Nascimento Silva, Emanuelle Souza Santos, Cássio Santana Meira, Cintia Figueiredo Araujo, Jéssica Vieira Cerqueira, Daniela Nascimento Silva, Fabíola Cardillo, Neuza Maria Alcântara-Neves, Milena Botelho Pereira Soares, Lain Carlos Pontes de Carvalho
This corrects the article on p. 406 in vol. 10, PMID: 29949837.
November 2018: Allergy, Asthma & Immunology Research
Seung Won Lee, Shinhae Lee, Youn Ho Sheen, Eun Kyo Ha, Sun Hee Choi, Min Suk Yang, Sohyun Hwang, Sung Soon Kim, Jang Hoon Choi, Man Yong Han
This corrects the article on p. 517 in vol. 9, PMID: 28913991.
November 2018: Allergy, Asthma & Immunology Research
Dong Keon Yon, Jaewoo An, Eun Kyo Ha, Hye Mi Jee, Kenji Izuhara, Junya Ono, Young Ho Jung, Kyung Suk Lee, Youn Ho Sheen, Heysung Baek, Man Yong Han
Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP₂₀₁₆) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children...
November 2018: Allergy, Asthma & Immunology Research
Kun Chen, Miaomiao Han, Mengyao Tang, Yadong Xie, Yuting Lai, Xianting Hu, Jia Zhang, Jun Yang, Huabin Li
PURPOSE: Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine Hrd1 expression and B-cell accumulation and their possible roles in CRSwNP. METHODS: Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay and Western blotting were used to assess gene and protein expression in nasal tissue extracts...
November 2018: Allergy, Asthma & Immunology Research
Chang Keun Kim, Zak Callaway, Jin Sung Park, Hisashi Nishimori, Tikatoshi Ogino, Mizuho Nagao, Takao Fujisawa
PURPOSE: Several markers for eosinophilic inflammation have been proposed to predict response to asthma treatment. However, definitive criteria for treatment decisions have not yet been established. We investigate a potentially useful relatively non-invasive biomarker, eosinophil-derived neurotoxin (EDN), to predict favorable responses to budesonide or montelukast, common treatment for children with asthma. METHODS: Young children (1 to 6 years old) were enrolled in this randomized, parallel, 2-group, open-label trial...
November 2018: Allergy, Asthma & Immunology Research
Ji Hye Kim, Ji Ho Lee, Young Min Ye, Jae Hyun Lee, Jung Won Park, Gyu Young Hur, Joo Hee Kim, Hyn Young Lee, Yoo Seob Shin, Eun Mi Yang, Hae Sim Park
PURPOSE: This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR. METHODS: A total of 45 patients aged ≥ 60 years with HDM-induced AR who had ≥ 3 A/H ratio on skin prick test and/or ≥ 0.35 IU/L to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15)...
November 2018: Allergy, Asthma & Immunology Research
Wat Mitthamsiri, Panitan Pradubpongsa, Atik Sangasapaviliya, Tadech Boonpiyathad
PURPOSE: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim of this study was to evaluate the levels of ILC subsets in allergic rhinitis (AR) patients in response to house dust mite (HDM)-specific immunotherapy. METHODS: We enrolled 37 AR patients undergoing AIT (16 responders and 11 non-responders) for 2 years, 35 HDM AR patients and 28 healthy subjects...
November 2018: Allergy, Asthma & Immunology Research
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