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Allergy, Asthma & Immunology Research

Luciana Souza De Aragão-França, Viviane Costa Junqueira Rocha, Andre Cronemberger-Andrade, Fábio Henrique Brasil Da Costa, Juliana Fraga Vasconcelos, Daniel Abensur Athanazio, Daniela Nascimento Silva, Emanuelle Souza Santos, Cássio Santana Meira, Cintia Figueiredo Araujo, Jéssica Vieira Cerqueira, Daniela Nascimento Silva, Fabíola Cardillo, Neuza Maria Alcântara-Neves, Milena Botelho Pereira Soares, Lain Carlos Pontes de Carvalho
This corrects the article on p. 406 in vol. 10, PMID: 29949837.
November 2018: Allergy, Asthma & Immunology Research
Seung Won Lee, Shinhae Lee, Youn Ho Sheen, Eun Kyo Ha, Sun Hee Choi, Min Suk Yang, Sohyun Hwang, Sung Soon Kim, Jang Hoon Choi, Man Yong Han
This corrects the article on p. 517 in vol. 9, PMID: 28913991.
November 2018: Allergy, Asthma & Immunology Research
Dong Keon Yon, Jaewoo An, Eun Kyo Ha, Hye Mi Jee, Kenji Izuhara, Junya Ono, Young Ho Jung, Kyung Suk Lee, Youn Ho Sheen, Heysung Baek, Man Yong Han
Epidemiological studies have shown that exposure to tobacco smoke causing irritation and inflammation in the airways tends to reduce serum periostin concentrations in adults. We now investigate prospective cross-sectional study on 135 Korean students aged 7 years in the first grade who were participating in the Seongnam Atopy Project for Children's Happiness 2016 (SAP₂₀₁₆) cohort. To the best of our knowledge, this is the first study to show significant inverse correlations between serum periostin concentration and exposure to xylene and formaldehyde in children...
November 2018: Allergy, Asthma & Immunology Research
Kun Chen, Miaomiao Han, Mengyao Tang, Yadong Xie, Yuting Lai, Xianting Hu, Jia Zhang, Jun Yang, Huabin Li
PURPOSE: Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine Hrd1 expression and B-cell accumulation and their possible roles in CRSwNP. METHODS: Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay and Western blotting were used to assess gene and protein expression in nasal tissue extracts...
November 2018: Allergy, Asthma & Immunology Research
Chang Keun Kim, Zak Callaway, Jin Sung Park, Hisashi Nishimori, Tikatoshi Ogino, Mizuho Nagao, Takao Fujisawa
PURPOSE: Several markers for eosinophilic inflammation have been proposed to predict response to asthma treatment. However, definitive criteria for treatment decisions have not yet been established. We investigate a potentially useful relatively non-invasive biomarker, eosinophil-derived neurotoxin (EDN), to predict favorable responses to budesonide or montelukast, common treatment for children with asthma. METHODS: Young children (1 to 6 years old) were enrolled in this randomized, parallel, 2-group, open-label trial...
November 2018: Allergy, Asthma & Immunology Research
Ji Hye Kim, Ji Ho Lee, Young Min Ye, Jae Hyun Lee, Jung Won Park, Gyu Young Hur, Joo Hee Kim, Hyn Young Lee, Yoo Seob Shin, Eun Mi Yang, Hae Sim Park
PURPOSE: This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR. METHODS: A total of 45 patients aged ≥ 60 years with HDM-induced AR who had ≥ 3 A/H ratio on skin prick test and/or ≥ 0.35 IU/L to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15)...
November 2018: Allergy, Asthma & Immunology Research
Wat Mitthamsiri, Panitan Pradubpongsa, Atik Sangasapaviliya, Tadech Boonpiyathad
PURPOSE: Group 2 innate lymphoid cells (ILC2s) have been implicated in the pathogenesis of allergic disease. However, the effect of allergen-specific immunotherapy (AIT) on ILCs remains to be clarified. The aim of this study was to evaluate the levels of ILC subsets in allergic rhinitis (AR) patients in response to house dust mite (HDM)-specific immunotherapy. METHODS: We enrolled 37 AR patients undergoing AIT (16 responders and 11 non-responders) for 2 years, 35 HDM AR patients and 28 healthy subjects...
November 2018: Allergy, Asthma & Immunology Research
Mi Ae Kim, Dong Kyu Kim, Hyeon Jong Yang, Young Yoo, Youngmin Ahn, Hae Sim Park, Hyun Jong Lee, Yi Yeong Jeong, Bong Seong Kim, Woo Yong Bae, An Soo Jang, Yang Park, Young Il Koh, Jaechun Lee, Dae Hyun Lim, Jeong Hee Kim, Sang Min Lee, Yong Min Kim, Young Joon Jun, Hyo Yeol Kim, Yunsun Kim, Jeong Hee Choi
PURPOSE: Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea. METHODS: Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled...
November 2018: Allergy, Asthma & Immunology Research
Ying Liu, Jing Zheng, Hong Ping Zhang, Xin Zhang, Lei Wang, Lisa Wood, Gang Wang
PURPOSE: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. METHODS: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin (IL)-1β, -4, -5, -6, -13, and tumor necrosis factor (TNF)-α, and serum was detected for leptin, adiponectin and C-reactive protein...
November 2018: Allergy, Asthma & Immunology Research
Joo Hee Kim, Hun Soo Chang, Seung Woo Shin, Dong Gyu Baek, Ji Hye Son, Choon Sik Park, Jong Sook Park
PURPOSE: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. METHODS: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year...
November 2018: Allergy, Asthma & Immunology Research
Dae Jin Song, Woo Jung Song, Jae Woo Kwon, Gun Woo Kim, Mi Ae Kim, Mi Yeong Kim, Min Hye Kim, Sang Ha Kim, Sang Heon Kim, Sang Hyuck Kim, Sun Tae Kim, Sae Hoon Kim, Ja Kyoung Kim, Joo Hee Kim, Hyun Jung Kim, Hyo Bin Kim, Kyung Hee Park, Jae Kyun Yoon, Byung Jae Lee, Seung Eun Lee, Young Mok Lee, Yong Ju Lee, Kyung Hwan Lim, You Hoon Jeon, Eun Jung Jo, Young Koo Jee, Hyun Jung Jin, Sun Hee Choi, Gyu Young Hur, Sang Heon Cho, Sang Hoon Kim, Dae Hyun Lim
Chronic cough is common in the community and causes significant morbidity. Several factors may underlie this problem, but comorbid conditions located at sensory nerve endings that regulate the cough reflex, including rhinitis, rhinosinusitis, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease, are considered important. However, chronic cough is frequently non-specific and accompanied by not easily identifiable causes during the initial evaluation. Therefore, there are unmet needs for developing empirical treatment and practical diagnostic approaches that can be applied in primary clinics...
November 2018: Allergy, Asthma & Immunology Research
Garima Sharma, Sin Hyeog Im
The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc. , dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics...
November 2018: Allergy, Asthma & Immunology Research
Tae Bum Kim
No abstract text is available yet for this article.
November 2018: Allergy, Asthma & Immunology Research
Minoru Gotoh, Osamu Kaminuma, Takachika Hiroi, Kimihiro Okubo
Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of SLIT in the treatment of cedar pollinosis (CP), we performed a multivariate analysis of microarray data on mRNA expression in CD4⁺ T cells and basophils. Although 2-year treatment with SLIT using cedar extracts was effective in >70% of patients with CP, the remaining patients did not respond to this therapy...
September 2018: Allergy, Asthma & Immunology Research
Heung Woo Park, Sang Heon Kim, Yoon Seok Chang, Sang Hoon Kim, Young Koo Jee, Ai Young Lee, In Jin Jang, Hae Sim Park, Kyung Up Min
PURPOSE: Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest the presence of genetic risk factors for SCARs other than drug-specific HLA. We aimed to identify a common genetic risk factor of SCARs across multiple drugs. METHODS: We performed 2 independent genome-wide association studies (GWASs). A total of 68 and 38 subjects with a diagnosis of SCAR were enrolled in each GWAS...
September 2018: Allergy, Asthma & Immunology Research
Si Chen, Yuting Han, Hao Chen, Jing Wu, Min Zhang
PURPOSE: T helper (Th) 17 cells play a critical role in the development of asthma, but the underlying mechanism of how interleukin (IL)-17 is regulated in allergic airway inflammation is poorly understood. In this study, we investigated the impact of Bcl11b on Th17 response in asthma. METHODS: Blood samples from patients with mild asthma (MA) and severe asthma (SA) were collected. Expression of Bcl11b, IL-4, IL-5, IL-13, IL-17A and transforming growth factor (TGF)-β1 were determined in CD4⁺ T cells and plasma by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA)...
September 2018: Allergy, Asthma & Immunology Research
Byeong Gon Kim, Pureun Haneul Lee, Sun Hye Lee, Ae Rin Baek, Jong Sook Park, Junehyuk Lee, Sung Woo Park, Do Jin Kim, Choon Sik Park, An Soo Jang
PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. METHODS: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls...
September 2018: Allergy, Asthma & Immunology Research
Min Hye Kim, Seng Jin Choi, Hyun Il Choi, Jun Pyo Choi, Han Ki Park, Eun Kyoung Kim, Min Jeong Kim, Byoung Seok Moon, Taek Ki Min, Mina Rho, Young Joo Cho, Sanghwa Yang, Yoon Keun Kim, You Young Kim, Bok Yang Pyun
PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles (EVs) secreted from bacteria affect the allergic inflammation process. However, almost all research carried out so far was related to local microorganisms, not the systemic microbial distribution. We aimed to compare the bacterial EV composition between AD patients and healthy subjects and to experimentally find out the beneficial effect of some bacterial EV composition...
September 2018: Allergy, Asthma & Immunology Research
Min Suk Yang, Sanghun Choi, Yera Choi, Kwang Nam Jin
PURPOSE: We aimed to investigate whether airway parameters, assessed via computed tomography (CT), are associated with abdominal fat areas and to compare the clinical characteristics of asthmatic patients with and without elevated visceral to subcutaneous fat area ratio (EV). METHODS: Asthmatic patients (aged ≥40 years) were prospectively recruited. Chest (airway) and fat areas were assessed via CT. Airway parameters, including bronchial wall thickness (WT), lumen diameter (LD), lumen area (LA), wall area (WA), total area (TA), as well as WA/TA percentage (wall area %) were measured at the apical segmental bronchus in the right upper lobe...
September 2018: Allergy, Asthma & Immunology Research
Dong Kyu Kim, Seong Il Kang, Il Gyu Kong, Young Hoon Cho, Seul Ki Song, Se Jin Hyun, Sung Dong Cho, Sang Yoon Han, Seong Ho Cho, Dae Woo Kim
PURPOSE: The previously reported Japanese clinical scoring study (JESREC) suggests that chronic rhinosinusitis (CRS) can be divided into 4 subtypes according to the degree of eosinophilic CRS (ECRS) and offers the information regarding the prognosis of CRS to clinicians. However, this scoring system has not yet been validated by an immunological study and needs to provide treatment guidelines based on underlying immunologic profiles. We investigated the immunologic profile of each CRS subgroup according to the JESREC classification and suggest its clinical application...
September 2018: Allergy, Asthma & Immunology Research
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