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Allergy, Asthma & Immunology Research

Minoru Gotoh, Osamu Kaminuma, Takachika Hiroi, Kimihiro Okubo
Sublingual immunotherapy (SLIT) is an effective treatment for allergic diseases. However, the mechanism by which this therapy exhibits its efficacy has not been fully delineated. To elucidate the mechanisms of SLIT in the treatment of cedar pollinosis (CP), we performed a multivariate analysis of microarray data on mRNA expression in CD4⁺ T cells and basophils. Although 2-year treatment with SLIT using cedar extracts was effective in >70% of patients with CP, the remaining patients did not respond to this therapy...
September 2018: Allergy, Asthma & Immunology Research
Heung Woo Park, Sang Heon Kim, Yoon Seok Chang, Sang Hoon Kim, Young Koo Jee, Ai Young Lee, In Jin Jang, Hae Sim Park, Kyung Up Min
PURPOSE: Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest the presence of genetic risk factors for SCARs other than drug-specific HLA. We aimed to identify a common genetic risk factor of SCARs across multiple drugs. METHODS: We performed 2 independent genome-wide association studies (GWASs). A total of 68 and 38 subjects with a diagnosis of SCAR were enrolled in each GWAS...
September 2018: Allergy, Asthma & Immunology Research
Si Chen, Yuting Han, Hao Chen, Jing Wu, Min Zhang
PURPOSE: T helper (Th) 17 cells play a critical role in the development of asthma, but the underlying mechanism of how interleukin (IL)-17 is regulated in allergic airway inflammation is poorly understood. In this study, we investigated the impact of Bcl11b on Th17 response in asthma. METHODS: Blood samples from patients with mild asthma (MA) and severe asthma (SA) were collected. Expression of Bcl11b, IL-4, IL-5, IL-13, IL-17A and transforming growth factor (TGF)-β1 were determined in CD4⁺ T cells and plasma by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA)...
September 2018: Allergy, Asthma & Immunology Research
Byeong Gon Kim, Pureun Haneul Lee, Sun Hye Lee, Ae Rin Baek, Jong Sook Park, Junehyuk Lee, Sung Woo Park, Do Jin Kim, Choon Sik Park, An Soo Jang
PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains unclear. The aim of this study was to investigate the association between CLDN5 levels and clinical variables in patients with COPD. METHODS: In total, 30 patients with COPD and 30 healthy controls were enrolled in the study. The plasma CLDN5 level was checked in patients with stable or exacerbated COPD and in healthy controls...
September 2018: Allergy, Asthma & Immunology Research
Min Hye Kim, Seng Jin Choi, Hyun Il Choi, Jun Pyo Choi, Han Ki Park, Eun Kyoung Kim, Min Jeong Kim, Byoung Seok Moon, Taek Ki Min, Mina Rho, Young Joo Cho, Sanghwa Yang, Yoon Keun Kim, You Young Kim, Bok Yang Pyun
PURPOSE: The microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles (EVs) secreted from bacteria affect the allergic inflammation process. However, almost all research carried out so far was related to local microorganisms, not the systemic microbial distribution. We aimed to compare the bacterial EV composition between AD patients and healthy subjects and to experimentally find out the beneficial effect of some bacterial EV composition...
September 2018: Allergy, Asthma & Immunology Research
Min Suk Yang, Sanghun Choi, Yera Choi, Kwang Nam Jin
PURPOSE: We aimed to investigate whether airway parameters, assessed via computed tomography (CT), are associated with abdominal fat areas and to compare the clinical characteristics of asthmatic patients with and without elevated visceral to subcutaneous fat area ratio (EV). METHODS: Asthmatic patients (aged ≥40 years) were prospectively recruited. Chest (airway) and fat areas were assessed via CT. Airway parameters, including bronchial wall thickness (WT), lumen diameter (LD), lumen area (LA), wall area (WA), total area (TA), as well as WA/TA percentage (wall area %) were measured at the apical segmental bronchus in the right upper lobe...
September 2018: Allergy, Asthma & Immunology Research
Dong Kyu Kim, Seong Il Kang, Il Gyu Kong, Young Hoon Cho, Seul Ki Song, Se Jin Hyun, Sung Dong Cho, Sang Yoon Han, Seong Ho Cho, Dae Woo Kim
PURPOSE: The previously reported Japanese clinical scoring study (JESREC) suggests that chronic rhinosinusitis (CRS) can be divided into 4 subtypes according to the degree of eosinophilic CRS (ECRS) and offers the information regarding the prognosis of CRS to clinicians. However, this scoring system has not yet been validated by an immunological study and needs to provide treatment guidelines based on underlying immunologic profiles. We investigated the immunologic profile of each CRS subgroup according to the JESREC classification and suggest its clinical application...
September 2018: Allergy, Asthma & Immunology Research
Yoko Inoue, Sakura Sato, Tetsuharu Manabe, Eishi Makita, Masako Chiyotanda, Kyohei Takahashi, Hitoshi Yamamoto, Noriyuki Yanagida, Motohiro Ebisawa
PURPOSE: Few studies have compared fractional exhaled nitric oxide (FeNO) measurement by NIOX VERO® (NOV) and other devices in children. Moreover, there is no agreement between differences in FeNO values obtained using different devices in adults. Here, we compared FeNO values obtained using NOV and NObreath® (NOB) systems to derive a correction equation for children. METHODS: Eighty-eight participants (age 7-15 years) who were diagnosed with atopic bronchial asthma and visited Sagamihara National Hospital as outpatients between January and April of 2017 were included...
September 2018: Allergy, Asthma & Immunology Research
Sungsu Jung, Dong In Suh, So Yeon Lee, Jisun Yoon, Hyun Ju Cho, Young Ho Kim, Song I Yang, Ji Won Kwon, Gwang Cheon Jang, Yong Han Sun, Sung Il Woo, You Sook Youn, Kang Seo Park, Hwa Jin Cho, Myung Hee Kook, Hye Ryoung Yi, Hai Lee Chung, Ja Hyeong Kim, Hyung Young Kim, Jin A Jung, Hyang Ok Woo, Soo Jong Hong
BACKGROUND: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate the prevalence, risk factors and cutoff value of bronchial hyperresponsiveness (BHR) to Provocholine in 7-year-old children. METHODS: Six hundred and thirty-three children from the Panel Study on Korean Children who visited 16 regional hospitals were evaluated...
September 2018: Allergy, Asthma & Immunology Research
Do Hyun Kim, Kyungdo Han, Soo Whan Kim
PURPOSE: Our aim was to explore whether antibiotic exposure in children and adolescents is associated with the later development of allergic diseases, using nationwide population-based claims data. METHODS: We collected information from the National Health Insurance Service (2006-2015) database. A total of 5,626,328 children and adolescents were eligible for the study. We explored whether exposure to antibiotics over the prior 7 years affects the later development of allergic diseases...
September 2018: Allergy, Asthma & Immunology Research
Ji Heui Kim, Yong Ju Jang
Natural killer (NK) cells have an immune regulatory function as well as cytotoxicity against tumor or infected cells. In the airway, although NK cells constitute a small proportion of the resident lymphocytes, they play an important role in the pathogenesis of chronic inflammatory airway diseases by modulating immune responses. NK cells can promote allergic airway inflammation by increasing the production of type 2 cytokines and inducing eosinophil migration. The increased activity of NK cells can develop or aggravate the destruction of lung parenchymal cells...
September 2018: Allergy, Asthma & Immunology Research
Manali Mukherjee, Parameswaran Nair
Asthma and autoimmune diseases both result from a dysregulated immune system, and have been conventionally considered to have mutually exclusive pathogenesis. Autoimmunity is believed to be an exaggerated Th1 response, while asthma with a Th2 underpinning is congruent with the well-accepted Th1/Th2 paradigm. The hypothesis of autoimmune involvement in asthma has received much recent interest, particularly in the adult late-onset non-atopic patients (the "intrinsic asthma"). Over the past decades, circulating autoantibodies against diverse self-targets (beta-2-adrenergic receptors, epithelial antigens, nuclear antigens, etc...
September 2018: Allergy, Asthma & Immunology Research
So Yeon Lee
No abstract text is available yet for this article.
September 2018: Allergy, Asthma & Immunology Research
Aneta Wagner, Hanna Zielińska-Bliźniewska, Waldemar Wagner
The major apple allergen Mal d 1 cross-reacts with the homologous birch pollen allergen Bet v 1 and causes immunoglobulin E (IgE)-mediated immediate-type allergic reactions. In some patients, delayed-type hypersensitivity to apples may develop within 72 hours without evidence of specific IgE or a positive skin prick test (SPT). The aim of the study was to evaluate the concomitance of delayed-type hypersensitivity reactions and immediate IgE-mediated reactions against high- and low-allergenic apple cultivars in patients with birch pollen allergy...
July 2018: Allergy, Asthma & Immunology Research
Luciana S Aragão-França, Viviane C J Rocha, Andre Cronemberger-Andrade, F H B Costa, José Fernandes Vasconcelos, Daniel Abensur Athanazio, Daniela Nascimento Silva, E S Santos, Cássio Santana Meira, C F Araújo, Jéssica Vieira Cerqueira, Fabíola Cardillo, Neuza Maria Alcântara-Neves, Milena Botelho Pereira Soares, Lain C Pontes-de-Carvalho
PURPOSE: The use of tolerogenic dendritic cells (TolDCs) to control exacerbated immune responses may be a prophylactic and therapeutic option for application in autoimmune and allergic conditions. The objective of this work was to evaluate the effects of TolDC administration in a mouse model of allergic airway inflammation caused by mite extract. METHODS: Mouse bone marrow-derived TolDCs were induced by incubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) and dexamethasone, and then characterized by flow cytometry and cytokine production by enzyme-linked immunosorbent assay (ELISA)...
July 2018: Allergy, Asthma & Immunology Research
Jeong Hyun Kim, So Yeon Lee, Mi Jin Kang, Jisun Yoon, Sungsu Jung, Hyun Ju Cho, Hyo Bin Kim, Soo Jong Hong
PURPOSE: Atopic dermatitis (AD) is a common and chronic inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide. Although previous reports including genome-wide association study (GWAS) approaches have identified several risk factors that appear to be associated with AD development, replication studies are lacking. In our current study, we replicated the associations between candidate susceptibility loci and AD. METHODS: A total of 885 Korean subjects (425 AD patients and 460 unaffected controls) were genotyped for 17 single nucleotide polymorphisms (SNPs) from previous GWASs and meta-analyses of AD and from immune-related genes...
July 2018: Allergy, Asthma & Immunology Research
So Young Park, Jung Hyun Kim, Hyo Jung Kim, Bomi Seo, Oh Young Kwon, Hun Soo Chang, Hyouk Soo Kwon, Tae Bum Kim, Ho Kim, Choon Sik Park, Hee Bom Moon, You Sook Cho
PURPOSE: The prevalence and burden of asthma is increasing worldwide. In this study, we analyzed 3 different Korean national health survey datasets to determine the general features of adult asthma in Korea and to obtain basic information that would support future strategies for better management of adult asthma. METHODS: The surveys used in this study included the Korea National Health and Nutrition Examination Survey (KNHANES), Korea Community Health Survey (KCHS) and National Health Insurance Service-National Sample Cohort (NHIS-NSC)...
July 2018: Allergy, Asthma & Immunology Research
Ebru Arik Yilmaz, Ozlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Umit M Sahiner, Bulent E Sekerel, Audrey DunnGalvin, Erdem Karabulut, Cansin Sackesen
PURPOSE: Food allergy (FA) affects the daily lives of children and parents in varying degrees. The Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) is a valid and reliable instrument to assess the quality of life (QoL) of children from parents' perception. The aim of this study was to validate and determine the reliability of the Turkish FAQLQ-PF and to assess QoL in food-allergic children. METHODS: Children aged between 0 and 12 years and diagnosed with immunoglobulin E (IgE)-mediated FA for at least 1 month were enrolled...
July 2018: Allergy, Asthma & Immunology Research
Kanokvalai Kulthanan, Supinda Chusakul, Marysia Tiongco Recto, Ma Teresita Gabriel, Derrick Chen Wee Aw, Narayanan Prepageran, Alson Wong, Jern Lin Leong, Henry Foong, Vo Thanh Quang, Torsten Zuberbier
PURPOSE: Across Hong Kong, Malaysia, the Philippines, Singapore, Thailand and Vietnam, (referred to as Asia) approximately 30-53 million individuals of the 151 million employed suffer from allergic rhinitis (AR) and urticaria. It is estimated that approximately 90% of patients with these allergic conditions are insufficiently treated, impacting the socioeconomic burden in terms of absence from work and decreased productivity. This study aims to estimate the socioeconomic burden of allergies in Asia and the cost savings that their adequate management can provide...
July 2018: Allergy, Asthma & Immunology Research
Jeongmin Lee, Kyunguk Jeong, Se Ah Jeon, Sooyoung Lee
PURPOSE: The immunological characteristics of young Korean children with walnut (WN) allergy and the influence of different cooking methods on WN proteins have not been evaluated to date. This study aimed to evaluate the major WN allergens identified among Korean children, together with changes in WN antigenicity caused by common cooking methods. METHODS: We enrolled children under the age of 13 years with WN serum-specific immunoglobulin (Ig) E concentrations. The protein fractions of dry-fried and boiled WN extracts were compared with those of raw WNs using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), 2-dimentional gel electrophoresis (2DE) and a proteomic analysis using electrospray ionization (liquid chromatography-mass spectrometry [LC-MS])...
July 2018: Allergy, Asthma & Immunology Research
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