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Allergy, Asthma & Immunology Research

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https://www.readbyqxmd.com/read/28677360/a-metagenomic-analysis-provides-a-culture-independent-pathogen-detection-for-atopic-dermatitis
#1
Min Hye Kim, Mina Rho, Jun Pyo Choi, Hyun Il Choi, Han Ki Park, Woo Jung Song, Taek Ki Min, Sang Heon Cho, Young Joo Cho, Yoon Keun Kim, Sanghwa Yang, Bok Yang Pyun
PURPOSE: Atopic dermatitis (AD) is an inflammatory skin disease, significantly affecting the quality of life. Using AD as a model system, we tested a successive identification of AD-associated microbes, followed by a culture-independent serum detection of the identified microbe. METHODS: A total of 43 genomic DNA preparations from washing fluid of the cubital fossa of 6 healthy controls, skin lesions of 27 AD patients, 10 of which later received treatment (post-treatment), were subjected to high-throughput pyrosequencing on a Roche 454 GS-FLX platform...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677359/efficacy-of-nasal-cellulose-powder-in-the-symptomatic-treatment-of-allergic-rhinitis-a-randomized-double-blind-placebo-controlled-trial
#2
Wiparat Manuyakorn, Natchanun Klangkalya, Wasu Kamchaisatian, Suwat Benjaponpita, Cherapat Sasisakulporn, Wanlapa Jotikasthira
PURPOSE: Nasal Cellulose Powder (NCP), which can prevent from binding an allergen to nasal mucosa, may reduce allergic rhinitis (AR) symptoms in dust mite-sensitized children. This study was conducted to assess the efficacy of NCP in improving clinical symptoms of a nasal airflow limitation and the response of nasal inflammatory cells. METHODS: Children with dust mite-sensitized AR aged 6-18 years were recruited. After a 4-week run-in period, NCP or a placebo was administered, 1 puff per nostril 3 times daily for 4 weeks...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677358/epidemiology-of-chronic-urticaria-in-korea-using-the-korean-health-insurance-database-2010-2014
#3
Nami Lee, Jeong Dong Lee, Hyun Young Lee, Dae Ryong Kang, Young Min Ye
PURPOSE: There are very few epidemiological studies on chronic urticaria (CU). We aimed to investigate the prevalence of CU and to depict demographics and medication patterns for the disease in a nationwide population-based study. METHODS: Data on urticaria (L50 of the International Classification of Diseases, 10th revision) from 2010 to 2014 were obtained from the Korean Health Insurance Review and Assessment Service. Algorithms designed to evaluate prescription drug claims for antihistamines were applied to identify CU...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677357/asthma-copd-overlap-shows-favorable-clinical-outcomes-compared-to-pure-copd-in-a-korean-copd-cohort
#4
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Jin Hwa Lee, Kyeong Cheol Shin, Soo Taek Uh, Seung Won Ra, Kwang Ha Yoo, Ki Suck Jung
PURPOSE: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. METHODS: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677356/age-based-causes-and-clinical-characteristics-of-immediate-type-food-allergy-in-korean-children
#5
Kyunguk Jeong, Jihyun Kim, Kangmo Ahn, So Yeon Lee, Taek Ki Min, Bok Yang Pyun, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu Earn Kim, Gwang Cheon Jang, Tae Won Song, Jung Hee Kim, You Hoon Jeon, Yong Ju Lee, Yong Mean Park, Hye Yung Yum, Hyun Hee Kim, Woo Kyung Kim, Sooyoung Lee
PURPOSE: Age-based causes and clinical characteristics of immediate-type food allergy (FA) have not been sufficiently studied. Therefore, we investigated age-dependent clinical profiles of FA in Korean children through an extensive multicenter investigation. METHODS: Using a case report form developed by the authors, a retrospective medical record review was performed of patients (0-18 years old) diagnosed with immediate-type FA between September 2014 and August 2015 in 14 tertiary hospitals in Korea...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677355/monoclonal-antibodies-to-recombinant-fag-e-3-buckwheat-allergen-and-development-of-a-two-site-elisa-for-its-quantification
#6
Kyoung Yong Jeong, Kyung Hee Park, Jae Hyun Lee, Jung Won Park
PURPOSE: Buckwheat is a major cause of anaphylaxis, and Fag e 3 is the key major allergen in buckwheat. However, an immunoassay system for the quantification of Fag e 3 has yet to be developed. METHODS: We developed a 2-site enzyme-linked immunosorbent assay (ELISA) using monoclonal antibodies (mAbs) produced against recombinant Fag e 3. We applied this ELISA to quantify native Fag e 3 in total buckwheat extract. RESULTS: Four clones of mAbs were produced, and all recognized vicilin allergens not only from buckwheat, but also from peanut and walnut...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677354/prevalence-of-immediate-type-food-allergy-in-korean-schoolchildren-in-2015-a-nationwide-population-based-study
#7
Minji Kim, Ji Young Lee, Hyun Young Jeon, Hea Kyoung Yang, Kee Jae Lee, Youngshin Han, Yang Hee Kim, Jihyun Kim, Kangmo Ahn
PURPOSE: This study aimed to determine the prevalence of immediate-type food allergy (FA) among schoolchildren in Korea. METHODS: A nationwide, cross-sectional study was performed in September 2015. A stratified random sample of 50,000 participants was selected from children and adolescents aged 6-7 years (n=17,500), 9-10 years (n=17,500), 12-13 years (n=7,500), and 15-16 years (n=7,500). Parents were asked to complete a questionnaire on the detailed history of immediate-type FA...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677353/individualized-treatment-of-allergic-rhinitis-according-to-nasal-cytology
#8
Jianjun Chen, Yue Zhou, Li Zhang, Yanjun Wang, Amber N Pepper, Seong H Cho, Weijia Kong
PURPOSE: Nasal cytology is important in the diagnosis and treatment of nasal inflammatory diseases. Treatment of allergic rhinitis (AR) according to nasal cytology has not been fully studied. We plan to explore the individualized treatment of AR according to nasal cytology. METHODS: Nasal cytology from 468 AR patients was examined for inflammatory cell quantity (grade 0-5) and the percentage of neutrophils and eosinophils. Results were subdivided into the following categories: AR(Eos), eosinophil ≥50% of the whole inflammatory cells; AR(Neu), neutrophils ≥90%; AR(Eos/Neu), 10%≤ eosinophil <50%; AR(Low), grade 0/1 inflammatory cell quantity...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677352/cough-hypersensitivity-syndrome-a-few-more-steps-forward
#9
REVIEW
Woo Jung Song, Alyn H Morice
Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677351/positioning-of-long-acting-muscarinic-antagonists-in-the-management-of-asthma
#10
REVIEW
René Aalbers, Hae Sim Park
Despite a range of efficacious therapies for asthma, including inhaled corticosteroids (ICS) and long-acting β₂-agonists (LABA), a significant proportion of patients have poor asthma control and retain a risk of future worsening of their symptoms. Long-acting muscarinic antagonist (LAMA) bronchodilators offer a well-tolerated, efficacious, and cost-effective add-on to a patient's treatment. Of the LAMAs currently under investigation or available for the treatment of asthma, evidence from a comprehensive clinical trial program in adults and children shows that once-daily treatment with tiotropium provides benefits for patients with uncontrolled asthma despite the use of ICS and LABAs...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28677350/individualized-treatment-for-allergic-rhinitis
#11
EDITORIAL
Sung Woo Cho, Dong Young Kim
No abstract text is available yet for this article.
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497926/plasma-lte4-pgf2%C3%AE-ratio-and-blood-eosinophil-count-are-increased-in-elderly-asthmatics-with-previous-asthma-exacerbation
#12
Ga Young Ban, Young Min Ye, Sang Ha Kim, Gyu Young Hur, Joo Hee Kim, Jae Jung Shim, Kumsun Cho, Joo Youn Cho, Hae Sim Park
The tools for asthma control assessment recommended by the current guideline are cognitive function- and effort-dependent, which is substantially impaired in the elderly. The aim of this study is to investigate objective assessment tools of asthma control status and previous asthma exacerbation (AE) in elderly subjects. Asthmatics aged >60 years who were treated with step 2 or 3 by the Global Initiative for Asthma (GINA) guideline were enrolled. During the 12-week study period, the subjects used either 400 μg of budesonide plus 10 mg of montelukast or 800 μg of inhaled budesonide...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497925/increased-risk-of-chronic-spontaneous-urticaria-in-patients-with-autoimmune-thyroid-diseases-a-nationwide-population-based-study
#13
Yoon Seob Kim, Kyungdo Han, Ji Hyun Lee, Nack In Kim, Joo Young Roh, Seong Jun Seo, Hae Jun Song, Min Geol Lee, Jee Ho Choi, Young Min Park
There was no previous population-based study on the comparison of the risk of chronic spontaneous urticaria (CSU) between autoimmune thyroid diseases (AITD) and age- and gender-matched controls. The primary objective of this study was to evaluate the risk of CSU after diagnosis of AITD using national registry data from Korea. The secondary objective was to evaluate other risk factors of CSU. Based on the disease code diagnoses in 2003-2005, we composed an AITD group (n=3,659) and an age- and gender-matched control group (n=18,295)...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497924/real-life-efficacy-of-omalizumab-after-9-years-of-follow-up
#14
Francesco Menzella, Carla Galeone, Debora Formisano, Claudia Castagnetti, Patrizia Ruggiero, Anna Simonazzi, Luigi Zucchi
Omalizumab is frequently used as add-on treatment to inhaled corticosteroids (ICS) and long-acting β2-agonists in patients with suboptimal control of severe asthma. Patients with severe asthma will typically require chronic treatment, although due to the limited amount of data available there are still some concerns about the safety and efficacy of long-term therapy with omalizumab. Herein, in an extension of a previous 4-year study, we report disease-related outcomes of 8 patients with severe persistent allergic asthma who have been followed for a total of 9 years in a real-life setting...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497923/ccr3-monoclonal-antibody-inhibits-eosinophilic-inflammation-and-mucosal-injury-in-a-mouse-model-of-eosinophilic-gastroenteritis
#15
Dae Jin Song, Mun Hee Shim, Nahyun Lee, Young Yoo, Ji Tae Choung
PURPOSE: Although the role of eosinophils in eosinophilic gastroenteritis (EGE) is not fully understood, they are believed to be a principal effector cell. Previous studies have demonstrated that eotaxin and its specific receptor, cysteine-cysteine chemokine receptor-3 (CCR3), play a central role in eosinophil trafficking into the gastrointestinal (GI) tract. Thus, we examined the targeting of CCR3 as a potential therapeutic intervention for EGE in a mouse model. METHODS: Eight- to 10-week-old BALB/c mice were intraperitoneally sensitized and intragastrically challenged with ovalbumin (OVA)...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497922/usefulness-of-in-vivo-and-in-vitro-diagnostic-tests-in-the-diagnosis-of-hypersensitivity-reactions-to-quinolones-and-in-the-evaluation-of-cross-reactivity-a-comprehensive-study-including-the-latest-quinolone-gemifloxacin
#16
Semra Demir, Asli Gelincik, Nilgun Akdeniz, Esin Aktas-Cetin, Muge Olgac, Derya Unal, Belkis Ertek, Raif Coskun, Bahattin Colakoğlu, Gunnur Deniz, Suna Buyukozturk
PURPOSE: Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others. We aimed to detect the usefulness of diagnostic tests of hypersensitivity reactions to quinolones and to evaluate the cross reactivity between different quinolones including the latest quinolone GFX. METHODS: We studied 54 patients (mean age 42...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497921/macrolide-resistance-and-its-impacts-on-m-pneumoniae-pneumonia-in-children-comparison-of-two-recent-epidemics-in-korea
#17
Jong Hyun Kim, Jee Yong Kim, Chang Hoon Yoo, Won Hee Seo, Young Yoo, Dae Jin Song, Ji Tae Choung
PURPOSE: The aim of this study was to investigate the change in macrolide resistance rate in pediatric Mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant M. pneumoniae (MRMP) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in Korea. METHODS: A total of 250 patients with M. pneumoniae pneumonia admitted to a single tertiary hospital were enrolled in this study. Detection of MRMP was based on specific point mutations in domain V of the 23S rRNA gene...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497920/prevalence-of-self-reported-allergic-diseases-and-ige-levels-a-2010-knhanes-analysis
#18
Hye Jung Park, Eun Jin Kim, Dankyu Yoon, Jeom Kyu Lee, Woo Sung Chang, Yoen Mi Lim, Jung Won Park, Joo Shil Lee
PURPOSE: The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea. METHODS: We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497919/accurate-determination-of-childhood-food-allergy-prevalence-and-correction-of-unnecessary-avoidance
#19
Yuki Okada, Takumi Yamashita, Hideki Kumagai, Yoshihiko Morikawa, Akira Akasawa
PURPOSE: Because the true prevalence of food allergy (FA), as based on the results of an oral food challenge test (OFC), is unknown, it is likely that children with suspected FA unnecessarily eliminate potentially causative foods. This study aimed to identify the prevalence of FA and to determine the proportion of children who unnecessarily eliminate food. METHODS: To identify children with FA, a primary survey was conducted via a questionnaire with all children aged 0-18 years in Niijima village (remote islands of Japan)...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497918/allergic-rhinitis-in-preschool-children-and-the-clinical-utility-of-feno
#20
Jisun Yoon, Yean Jung Choi, Eun Lee, Hyun Ju Cho, Song I Yang, Young Ho Kim, Young Ho Jung, Ju Hee Seo, Ji Won Kwon, Hyo Bin Kim, So Yeon Lee, Bong Seong Kim, Jung Yeon Shim, Eun Jin Kim, Joo Shil Lee, Soo Jong Hong
PURPOSE: The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized. This study aimed to investigate the prevalence of AR and its associated risk factors in preschool-aged children and to assess the clinical utility of fractional exhaled nitric oxide (FeNO). METHODS: This general population-based, cross-sectional survey included 933 preschool-aged (3- to 7-year-old) children from Korea. Current AR was defined as having nasal symptoms within the last 12 months and physician-diagnosed AR...
July 2017: Allergy, Asthma & Immunology Research
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