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Allergy, Asthma & Immunology Research

Hye Jung Park, Kyung Soo Suk, Jung Won Park
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized...
March 2018: Allergy, Asthma & Immunology Research
Todor A Popov, Jean Emberlin, Nils Åberg, Peter Josling, Martin Church
No abstract text is available yet for this article.
March 2018: Allergy, Asthma & Immunology Research
Sang Pyo Lee, Joo Hyun Jung, Sang Min Lee, Eugene Joe, Il Gyu Kang, Seon Tae Kim, Min Woo Lee, So Hyun Park, Seung Joon Choi
No abstract text is available yet for this article.
March 2018: Allergy, Asthma & Immunology Research
Tien Jen Lin, Wilfried J J Karmaus, Mei Lien Chen, Jiin Chyr Hsu, I Jen Wang
PURPOSE: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. METHODS: We conducted a case-control study comprised of 126 asthmatic children and 327 controls...
March 2018: Allergy, Asthma & Immunology Research
Min Suk Yang, Sang Il Choi, Woo Jung Song, Sae Hoon Kim, Sang Heon Cho, Kyung Up Min, Jae Hyoung Kim, Yoon Seok Chang
PURPOSE: Patients with a history of radiocontrast media (RCM) hypersensitivity can be overlooked, resulting in repeated reactions. Therefore, a consultation support system for RCM hypersensitivity has been in operation at Seoul National University Bundang Hospital since December 2011. We analyzed the effect of this system on physicians' practice. METHODS: A retrospective study was conducted on patients with previous RCM reactions (December 1, 2010 to November 30, 2012)...
March 2018: Allergy, Asthma & Immunology Research
Min Suk Yang, Sang Pyo Lee, Young Jae Kwon, Sang Min Lee
PURPOSE: This study evaluated dog and cat allergies and their association with allergen avoidance measures in Korean adults. METHODS: The study population consisted of 537 adults who currently kept dogs or cats and participated in a pet exhibition in Korea. The subjects were asked to complete questionnaires regarding pet ownership, allergen avoidance, and allergy symptoms, and underwent skin prick tests. They were considered to have a dog or cat allergy if they suffered from one or more of allergy symptoms during contact with their pets...
March 2018: Allergy, Asthma & Immunology Research
Sylwia Moskwa, Wojciech Piotrowski, Jerzy Marczak, Małgorzata Pawełczyk, Anna Lewandowska-Polak, Marzanna Jarzębska, Małgorzata Brauncajs, Anna Głobińska, Paweł Górski, Nikolaos G Papadopoulos, Michael R Edwards, Sebastian L Johnston, Marek L Kowalski
PURPOSE: In order to gain an insight into determinants of reported variability in immune responses to respiratory viruses in human bronchial epithelial cells (HBECs) from asthmatics, the responses of HBEC to viral infections were evaluated in HBECs from phenotypically heterogeneous groups of asthmatics and in healthy controls. METHODS: HBECs were obtained during bronchoscopy from 10 patients with asthma (6 atopic and 4 non-atopic) and from healthy controls (n=9) and grown as undifferentiated cultures...
March 2018: Allergy, Asthma & Immunology Research
Byungho Choi, Sun Hyu Kim, Hyeji Lee
PURPOSE: There has been active research on anaphylaxis, but many study subjects are limited to patients registered with anaphylaxis codes. However, anaphylaxis codes tend to be underused. The aim of this study was to investigate the accuracy of anaphylaxis code registration and the clinical characteristics of accurate and inaccurate anaphylaxis registration in anaphylactic patients. METHODS: This retrospective study evaluated the medical records of adult patients who visited the university hospital emergency department between 2012 and 2016...
March 2018: Allergy, Asthma & Immunology Research
Yun Jung Choi, Dong In Suh, Myung Hyun Sohn, Young Yull Koh
PURPOSE: Dyspnea is not widely utilized as an indicator of asthma provocation despite its universal presentation. We hypothesized that dyspnea severity was proportionate with the lung function decline, methacholine dose-step, and the degree of bronchial hyperresponsiveness (BHR). METHODS: We retrospectively analyzed 73 children's bronchial provocation test data with an assessment of dyspnea at every dose-step. Dyspnea severity was scored using a modified Borg (mBorg) scale...
March 2018: Allergy, Asthma & Immunology Research
Ji Ho Lee, Hyun Young Lee, Chang Gyu Jung, Ga Young Ban, Yoo Seob Shin, Young Min Ye, Dong Ho Nahm, Hae Sim Park
PURPOSE: Omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, has proved to be effective for the treatment of severe asthma. However, there is no direct evidence of effectiveness of omalizumab in Korean patients with severe asthma. We sought to evaluate the real-world effectiveness of omalizumab in Korean adult patients suffering from severe asthma and to identify predictors of favorable response. METHODS: A retrospective analysis of electrical medical records was performed on severe allergic asthmatic patients with omalizumab treatment group (OT group) for more than 6 months between March 2008 and February 2016...
March 2018: Allergy, Asthma & Immunology Research
Jae Seok Jeong, So Ri Kim, Yong Chul Lee
Severe asthma is a heterogeneous disease entity to which diverse cellular components and pathogenetic mechanisms contribute. Current asthma therapies, including new biologic agents, are mainly targeting T helper type 2 cell-dominant inflammation, so that they are often unsatisfactory in the treatment of severe asthma. Respiratory fungal exposure has long been regarded as a precipitating factor for severe asthma phenotype. Moreover, as seen in clinical definitions of allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS), fungal allergy-associated severe asthma phenotype is increasingly thought to have distinct pathobiologic mechanisms requiring different therapeutic approaches other than conventional treatment...
March 2018: Allergy, Asthma & Immunology Research
Sanny K Chan, Donald Y M Leung
Allergies to dogs and cats affect 10%-20% of the population worldwide and is a growing public health concern as these rates increase. Given the prevalence of detectable dog and cat allergens even in households without pets, there is a critical need to accurately diagnose and treat patients to reduce morbidity and mortality from exposure. The ability to diagnose cat sensitization is good, in contrast to dogs. Component resolved diagnostics of sensitization to individual allergenic proteins will dramatically improve diagnosis...
March 2018: Allergy, Asthma & Immunology Research
Doh Hyung Kim, Young Koo Jee
No abstract text is available yet for this article.
March 2018: Allergy, Asthma & Immunology Research
Sang Hoon Kim, Tae Bum Kim, Sang Heon Kim, Heung Woo Park, Sook Hee Song, Jae Won Jeong, Young Koo Jee, Sang Won Park, Mi Sun Kim, Ho Joo Yoon
The aim of this study was to examine the daily practice patterns of Symbicort® Maintenance and Reliever Therapy (SMART) in Korean asthmatic patients and to analyze clinical signs related to overuse. This study used an observational, multicenter, noninterventional, prospective, uncontrolled design for examining asthmatic patients prescribed SMART to assess the frequency and pattern of Symbicort® usage as a maintenance and reliever medication. The characteristics of patients showing signs of overuse (frequency of inhalation: 8 or more times per day) were also analyzed...
January 2018: Allergy, Asthma & Immunology Research
Yoon Seob Kim, Sang Hyun Park, Kyungdo Han, Ji Hyun Lee, Nack In Kim, Joo Young Roh, Seong Jun Seo, Hae Jun Song, Min Geol Lee, Jee Ho Choi, Young Min Park
Knowledge of the clinical course of chronic spontaneous urticaria (CSU) remains unclear. The purpose of our study was to investigate the clinical course of CSU in the Korean adult population. Each patient in the CSU group who was defined by disease codes between 2003 and 2007 was tracked whether he or she went into remission or not until 2013. Kaplan-Meier survival analysis was carried out to analyze remission, and log-rank tests were performed for between-group comparisons. Demographic differences between subjects who went into remission 1 year after the initial diagnosis and those who did not were analyzed using χ² tests...
January 2018: Allergy, Asthma & Immunology Research
Osamu Kaminuma, Tomoe Nishimura, Noriko Kitamura, Mayumi Saeki, Takachika Hiroi, Akio Mori
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation and activation of eosinophils, whether they induce eosinophilic skin inflammation, independent of the IgE-mediated pathway has been unclear. To address the functional role of T cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or naive DO11.10 T cells into unprimed BALB/c mice...
January 2018: Allergy, Asthma & Immunology Research
Thanyapat Jarupalee, Pantipa Chatchatee, Kittinan Komolpis, Narissara Suratannon, Sittiruk Roytrakul, Yodying Yingchutrakul, Wanaporn Yimchuen, Patcharavadee Butta, Alain Jacquet, Tanapat Palaga
BACKGROUND: Black tiger shrimp Penaeus monodon is one of the common causes of shellfish allergy that is increasing worldwide. One of the important problems in the management of shellfish allergy is the lack of accurate diagnostic assay because the biological and immunological properties of allergens in black tiger shrimp have not been well characterized. This study aims to detect proteins with the ability to bind and cross-link immunoglobulin E (IgE) from black tiger shrimp by enzyme-linked immunosorbent assay (ELISA), Western blot, and a humanized rat basophilic leukemia reporter cell line RS-ATL8...
January 2018: Allergy, Asthma & Immunology Research
Wei Yang, Toshishige Shibamoto, Yuhichi Kuda, Tao Zhang, Mamoru Tanida, Yasutaka Kurata
PURPOSE: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, develop severe anaphylaxis, but the mechanism remains unknown. We determined effects of β₁- and β₂-adrenoceptor antagonists on the anaphylaxis-induced increase in vascular permeability in mice. METHODS: In anesthetized ovalbumin-sensitized C57BL mice, mean arterial blood pressure (MBP) was measured, and Evans blue dye extravasation and hematocrit (Hct) were assessed at 20 minutes after antigen injection...
January 2018: Allergy, Asthma & Immunology Research
Michael D Kennedy, Martin Faulhaber
PURPOSE: Cold weather exercise is common in many regions of the world; however, it is unclear whether respiratory function and symptom worsen progressively with colder air temperatures. Furthermore, it is unclear whether high-ventilation sport background exacerbates dysfunction and symptoms. METHODS: Seventeen active females (measure of the maximum volume of oxygen [VO(2max)]: 49.6±6.6 mL·kg⁻¹·min⁻¹) completed on different days in random order 5 blinded running trials at 0°C, -5°C, -10°C, -15°C, and -20°C (humidity 40%) in an environmental chamber...
January 2018: Allergy, Asthma & Immunology Research
Xu Zhang, Feng Lan, Yuan Zhang, Luo Zhang
PURPOSE: Chinese herbal medicine (CHM) has been widely used in China to treat allergic rhinitis (AR). However, several studies have produced conflicting data with regard to the efficacy of the medicine. Our aim was to perform a meta-analysis of randomized clinical trials (RCTs) to evaluate the relative efficacy of CHM. METHODS: We systematically searched the PubMed, Medline, and Springer electronic databases up to March 2017 for RCTs comparing the efficacy of CHM versus placebo for the treatment of patients with AR...
January 2018: Allergy, Asthma & Immunology Research
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