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Allergy, Asthma & Immunology Research

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https://www.readbyqxmd.com/read/28102066/erratum-in-vitro-evaluation-of-allergen-potencies-of-commercial-house-dust-mite-sublingual-immunotherapy-reagents
#1
Kyung Hee Park, Mina Son, Soo Young Choi, Hey Jung Park, Jae Hyun Lee, Kyoung Yong Jeong, Joo Shil Lee, Jung Won Park
This corrects the article on p. 124 in vol. 7, PMID: 25729619.
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102065/comment-on-long-term-effects-of-diesel-exhaust-particles-on-airway-inflammation-and-remodeling-in-a-mouse-model-by-kim-et-al
#2
LETTER
Alexander N Larcombe, Anthony Kicic, Benjamin J Mullins
No abstract text is available yet for this article.
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102064/fixed-food-eruption-caused-by-actinidia-arguta-hardy-kiwi-a-case-report-and-literature-review
#3
LETTER
Kyoung Hee Sohn, Byung Keun Kim, Ju Young Kim, Woo Jung Song, Hye Ryun Kang, Heung Woo Park, Sang Heon Cho, Kyung Up Min
Fixed drug eruption (FDE) is a common hypersensitivity reaction characterized by recurrent, well-circumscribed, erythematous patches that arise at the same site as a result of systemic drug exposure. However, fixed food eruption (FFE), a lesion triggered by food ingestion, is a rare allergy that was first defined in 1996. Based on their anti-inflammatory and anti-oxidant properties, the fruit and leaves of Actinidia arguta, the hardy kiwi, are widely consumed across Korea, Japan, and China. This report describes the first case of FFE caused by hardy kiwi leaves, known as Daraesun in Korean, confirmed by oral provocation tests and skin biopsy...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102063/sputum-inflammatory-mediators-are-increased-in-aspergillus-fumigatus-culture-positive-asthmatics
#4
Michael A Ghebre, Dhananjay Desai, Amisha Singapuri, Joanne Woods, Laura Rapley, Suzanne Cohen, Athula Herath, Andrew J Wardlaw, Catherine H Pashley, Richard May, Chris E Brightling
Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of 24 sputum inflammatory mediators in A. fumigatus culture-positive or-negative moderate-to-severe asthmatics. Fifty-two subjects were recruited from a single center. A. fumigatus was cultured from 19 asthmatics. Asthma control, symptom score, lung function, and sputum cell count were not significantly different between the asthmatics with and without a positive A...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102062/the-role-of-il-17-in-a-lipopolysaccharide-induced-rhinitis-model
#5
Jun Sang Bae, Ji Hye Kim, Eun Hee Kim, Ji Hun Mo
PURPOSE: Lipopolysaccharide (LPS) is a cell wall component of Gram-negative bacteria and important for pro-inflammatory mediators. This study aimed to establish a rhinitis model using ovalbumin (OVA) and LPS in order to evaluate the role of interleukin (IL)-17 in the pathogenesis of an LPS-induced non-eosionophilic rhinitis model. METHODS: Mice were divided into 4 groups and each group consisted of 10 mice (negative control group, allergic rhinitis model group, 1-μg LPS treatment group, and 10-μg LPS treatment group)...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102061/clinical-diversity-of-atopic-dermatitis-a-review-of-5-000-patients-at-a-single-institute
#6
Howard Chu, Jung U Shin, Chang Ook Park, Hemin Lee, Jungsoo Lee, Kwang Hoon Lee
PURPOSE: Atopic dermatitis (AD) is a chronic eczematous dermatitis that has a high prevalence and diverse clinical features. Although several hypotheses about its multifactorial pathogenesis have been suggested, the cause is not yet fully understood. A better understanding of the clinical features may helpful inelucidating the pathogenesis of AD. METHODS: This retrospective study analyzed the questionnaires, medical charts, and laboratory examination results of 5,000 patients diagnosed with AD at a single tertiary hospital in Korea...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102060/usefulness-of-house-dust-mite-nasal-provocation-test-in-asthma
#7
Inseon S Choi, Soo Jeong Kim, Joo Min Won, Myeong Soo Park
PURPOSE: We previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs) in patients with asthma. Because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to HDM than the skin test. METHODS: The allergy skin prick test and nasal and bronchial provocation tests using HDM (Dermatophagoides farinae) were performed in 41 young men (age, 19-28 years) who wanted military certification for asthma...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102059/v%C3%AE-1%C3%A2-%C2%BA-%C3%AE-%C3%AE-t-cells-are-correlated-with-increasing-expression-of-eosinophil-cationic-protein-and-metalloproteinase-7-in-chronic-rhinosinusitis-with-nasal-polyps-inducing-the-formation-of-edema
#8
Luo Ying Yang, Xia Li, Wen Ting Li, Jian Cong Huang, Zhi Yuan Wang, Zi Zhen Huang, Li Hong Chang, Ge Hua Zhang
PURPOSE: We have found that expression of γδT cells is increased in pathological mucosa of chronic rhinosinusitis with nasal polyps (CRSwNP) compared with normal nasal mucosa. This increase is correlated with the infiltration of eosinophils in CRSwNP. Here, we investigated the expression of γδT cells, inflammation and tissue remodeling factors as well as their probable relationships in different types of chronic rhinosinusitis (CRS) in China. METHODS: A total of 76 surgical tissue samples that included 43 CRSwNP samples (15 eosinophilic and 28 non-eosinophilic), 17 CRS samples without nasal polyps (CRSsNP), and 16 controls were obtained...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102058/neonatal-immune-state-is-influenced-by-maternal-allergic-rhinitis-and-associated-with-regulatory-t-cells
#9
Lu Tan, Jing Ou, Zezhang Tao, Yonggang Kong, Yu Xu
PURPOSE: Maternal influences contribute to the origin of allergic diseases, but the mechanisms are not clear. The current literature prompted the role of epigenetics in the development of allergic diseases. We sought to investigate the roles of regulatory T (Treg) cells and Forkhead box p3 (Foxp3) DNA methylation in the process of maternal transmission of allergic rhinitis (AR) susceptibility. METHODS: BALB/c female mice (AR mother) were sensitized by intraperitoneal injection of Dermatophagoides pteronyssinus (Der p) 1 on day 1 and 7...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102057/periostin-in-exhaled-breath-condensate-and-in-serum-of-asthmatic-patients-relationship-to-upper-and-lower-airway-disease
#10
Aleksandra Wardzyńska, Joanna S Makowska, Małgorzata Pawełczyk, Aleksandra Piechota-Polańczyk, Marcin Kurowski, Marek L Kowalski
PURPOSE: Periostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) and chronic rhinosinusitis (CRS). In this study, we aimed to evaluate periostin in exhaled breath condensate (EBC) and in serum of patients with various asthma phenotypes. METHODS: The study included 40 asthmatic patients (22 with NERD) and 17 healthy controls. All the procedures (questionnaire, spirometry, FeNO, nasal swabs, EBC collecting, and blood sampling) were performed on the same day...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102056/asthma-related-outcomes-in-patients-initiating-extrafine-ciclesonide-or-fine-particle-inhaled-corticosteroids
#11
Dirkje S Postma, Richard Dekhuijzen, Thys van der Molen, Richard J Martin, Wim van Aalderen, Nicolas Roche, Theresa W Guilbert, Elliot Israel, Daniela van Eickels, Javaria Mona Khalid, Ron M C Herings, Jetty A Overbeek, Cristiana Miglio, Victoria Thomas, Catherine Hutton, Elizabeth V Hillyer, David B Price
PURPOSE: Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS. We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate or non-extrafine beclomethasone). METHODS: This historical, matched cohort study included patients aged 12-60 years prescribed their first ICS as ciclesonide or fine-particle ICS. The 2 cohorts were matched 1:1 for key demographic and clinical characteristics over the baseline year...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102055/role-of-regulatory-cells-in-oral-tolerance
#12
REVIEW
Marcin Wawrzyniak, Liam O'Mahony, Mübeccel Akdis
The immune system is continuously exposed to great amounts of different antigens from both food and intestinal microbes. Immune tolerance to these antigens is very important for intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by exposure to antigen via the oral route. Investigations on the role of intestinal immune system in preventing hypersensitivity reactions to innocuous dietary and microbial antigens have been intensively performed during the last 2 decades...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102054/extracellular-vesicles-a-key-mediator-to-link-environmental-microbiota-to-airway-immunity
#13
REVIEW
Youngwoo Choi, Hanki Park, Hae Sim Park, Yoon Keun Kim
Asthma is considered the hallmark of chronic airway inflammation, in which several inflammatory cells of the innate and adaptive immune system act together. The disease is thought to be caused by a combination of genetic and environmental factors; however, precise mechanisms for airway inflammation remain unclear. The human microbiota provides an increasingly favored explanation for inflammatory diseases; an altered microbiota composition has been shown to regulate immune responses. However, given the complexity of the microbiota, additional research is needed to elucidate its role in the development of disease...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28102053/size-of-inhaled-corticosteroid-and-small-airway-inflammation-in-asthma
#14
EDITORIAL
Choon Sik Park
No abstract text is available yet for this article.
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826968/a-case-of-type-2-hereditary-angioedema-with-serping1-mutation
#15
Da Woon Sim, Kyung Hee Park, Jae Hyun Lee, Jung Won Park
Hereditary angioedema is a disease of congenital deficiency or functional defect in the C1 esterase inhibitor (C1-INH) consequent to mutation in the SERPING1 gene, which encodes C1-INH. This disease manifests as recurrent, non-pitting, non-pruritic subcutaneous, or submucosal edema as well as an erythematous rash in some cases. These symptoms result from the uncontrolled localized production of bradykinin. The most commonly affected sites are the extremities, face, gastrointestinal tract, and respiratory system...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826967/palonosetron-induced-anaphylaxis-during-general-anesthesia-a-case-report
#16
Hyungjun Park, Kyunghwan Oh, Hoonhee Lee, Ji Hyang Lee, Sun Myoung Kang, So Young Park, Hyouk Soo Kwon, You Sook Cho, Hee Bom Moon, Tae Bum Kim
Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In this report, we describe a 37-year-old male who developed severe hypersensitivity reactions to palonosetron during surgery for kidney donation. His medical history was unremarkable, except for inguinal hernia with herniorrhaphy 8 years ago...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826966/association-of-mbl-with-work-related-respiratory-symptoms-in-bakery-workers
#17
Mi Ae Kim, Moon Kyung Yoon, Seung Hyun Kim, Hae Sim Park
Baker's asthma is the most prevalent occupational asthma, and IgE-mediated response is known as a major pathogenesis. However, recent studies have suggested the involvement of innate immune response because wheat flour contains bacterial endotoxins or lipopolysaccharides. To further understand a role of innate immune response in the development of work-related respiratory symptoms (WRS) in bakery workers, we investigated mannose-binding lectin (MBL), one of the initiating components of the complement cascade in a single cohort of bakery workers...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826965/validation-of-a-rapid-robust-inexpensive-screening-method-for-detecting-the-hla-b-58-01-allele-in-the-prevention-of-allopurinol-induced-severe-cutaneous-adverse-reactions
#18
Dinh Van Nguyen, Christopher Vida, Hieu Chi Chu, Richard Fulton, Jamma Li, Suran L Fernando
The HLA B*58:01 allele has been worldwide reported as a pharmacogenetic susceptibility to allopurinol-induced severe cutaneous adverse reactions (SCARs). To prevent these life-threatening conditions, the American College of Rheumatology hingly recommended that the HLA-B*58:01 be screened prior to the initiation of allopurinol therapy. Therefore, we developed a rapid, robust, inexpensive screening method using SYBR® Green real time PCR to detect the HLA-B*58:01 allele. A total of 119 samples were tested. The assay has a sensitivity of 100% (95% CI: 69...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826964/comorbidities-and-phenotypes-of-rhinitis-in-korean-children-and-adolescents-a-cross-sectional-multicenter-study
#19
Kyung Suk Lee, Hye Yung Yum, Youn Ho Sheen, Yong Mean Park, Yong Ju Lee, Bong Seok Choi, Hye Mi Jee, Sun Hee Choi, Hyun Hee Kim, Yang Park, Hyo Bin Kim, Yeong Ho Rha
PURPOSE: Rhinitis is a nasal inflammatory disease in children and adolescents. However, little is known about the phenotypes and characteristics of allergic rhinitis (AR) in Korean children and adolescents. The objective of this study was to analyze the symptoms and comorbidities of rhinitis, to compare AR to non-allergic rhinitis (NAR), and to reveal the phenotypes and features of AR in a Korean pediatric population. METHODS: Patients under 18 years of age with rhinitis symptoms were recruited from January 2013 to January 2015 by pediatric allergists...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27826963/inhibition-of-allergic-response-by-intranasal-selective-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotides-in-a-murine-model-of-allergic-rhinitis
#20
Jee Hye Wee, Yu Lian Zhang, Chae Seo Rhee, Dong Young Kim
PURPOSE: It remains unknown whether local inhibition of Nuclear factor-kappa B (NF-κB) could have therapeutic value in the treatment of allergic rhinitis (AR). This study aimed to evaluate the effect of selective NF-κB inhibition using NF-κB decoy oligodeoxynucleotides (ODNs) for the local treatment of AR in ovalbumin (OVA)-sensitized wild-type mice. METHODS: BALB/c mice were sensitized with OVA and alum, and then challenged intranasally with OVA. NF-κB decoy ODNs were given intranasally to the treatment group, and NF-κB scrambled ODNs were given to the sham treatment group...
January 2017: Allergy, Asthma & Immunology Research
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