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Cartilage

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https://www.readbyqxmd.com/read/27994723/return-to-sports-after-bone-marrow-derived-cell-transplantation-for-osteochondral-lesions-of-the-talus
#1
Francesca Vannini, Marco Cavallo, Laura Ramponi, Francesco Castagnini, Simone Massimi, Sandro Giannini, Roberto Emanuele Buda
OBJECTIVE: Arthroscopic "one-step" technique based on bone marrow-derived cell transplantation (BMDCT) have achieved good results in repairing osteochondral lesions of the talus (OLT), overcoming important drawbacks of older techniques. It may be particularly adequate for the treatment of athletes in order to permit a safe and stable return to sports. The aim of this study was to report the results at 48 months of a series of athletes and the factors influencing the return to sports. DESIGN: Case series...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994722/immediate-unrestricted-postoperative-weightbearing-and-mobilization-after-bone-marrow-stimulation-of-large-osteochondral-lesions-of-the-talus
#2
Gregory A Lundeen, Linda J Dunaway
OBJECTIVE: There remains no consensus on a postoperative protocol following arthroscopic treatment of osteochondral lesions of the talus (OLTs) and most studies report a period of immobilization and nonweightbearing. Outcomes are believed to decrease with larger size. The purpose of our study was to evaluate patients who underwent arthroscopic treatment of large (≥150 mm(2)) OLTs with immediate unrestricted weightbearing and mobilization postoperatively. DESIGN: Patients who underwent arthroscopic bone marrow stimulation for osteochondral defects were identified...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994721/particulated-juvenile-articular-cartilage-allograft-transplantation-for-osteochondral-talar-lesions
#3
Bryan M Saltzman, Johnny Lin, Simon Lee
OBJECTIVE: To report on our institution's early results from juvenile particulate cartilage allograft transplantation of the talus. DESIGN: Because of the relative rarity of the procedure at the talus, it was decided to provide a comprehensive understanding of the currently available evidence via a 2-part study with (1) a systematic review of the literature and (2) a retrospective single-center cohort study of the authors' patients, their demographics, and their early outcomes...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#4
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994719/operative-treatment-for-osteochondral-lesions-of-the-talus-biologics-and-scaffold-based-therapy
#5
REVIEW
Youichi Yasui, Adi Wollstein, Christopher D Murawski, John G Kennedy
OBJECTIVE: Numerous basic science articles have published evidence supporting the use of biologic augmentation in the treatment of osteochondral lesions of the talus (OLT). However, a comprehensive evaluation of the clinical outcomes of those treatment modalities in OLT has yet to be published. The purpose of this review is to provide an evidence-based overview of clinical outcomes following biologic augmentation to surgical treatments for OLT. DESIGN: A comprehensive literature review was performed...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994718/new-technology-in-imaging-cartilage-of-the-ankle
#6
REVIEW
Markus M Schreiner, Vladimir Mlynarik, Štefan Zbýň, Pavol Szomolanyi, Sebastian Apprich, Reinhard Windhager, Siegfried Trattnig
The incidence of osteochondral lesions, as well as osteoarthritis of the ankle joint following osteochondritis dissecans and trauma, has been reappraised in recent years. Consequently, an increasing number of surgical interventions using different cartilage repair techniques is performed in the ankle joint, which has resulted in a growing demand for repetitive and objective assessment of cartilage tissue and its repair. While morphological imaging does enable monitoring of macroscopic changes with increasing precision, it fails to provide information about the ultrastructural composition of cartilage...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994717/evaluation-and-management-of-osteochondral-lesions-of-the-talus
#7
REVIEW
Christopher A Looze, Jason Capo, Michael K Ryan, John P Begly, Cary Chapman, David Swanson, Brian C Singh, Eric J Strauss
Osteochondral lesions of the talus are common injuries that affect a wide variety of active patients. The majority of these lesions are associated with ankle sprains and fractures though several nontraumatic etiologies have also been recognized. Patients normally present with a history of prior ankle injury and/or instability. In addition to standard ankle radiographs, magnetic resonance imaging and computed tomography are used to characterize the extent of the lesion and involvement of the subchondral bone...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994716/peculiarities-in-ankle-cartilage
#8
REVIEW
Matthew J Kraeutler, Tanyaporn Kaenkumchorn, Cecilia Pascual-Garrido, Markus A Wimmer, Susanna Chubinskaya
Posttraumatic osteoarthritis (PTOA) is the most common form of osteoarthritis (OA) of the ankle joint. PTOA occurs as a result of several factors, including the poor regenerative capacity of hyaline articular cartilage as well as increased contact stresses following trauma. The purpose of this article is to review the epidemiology, pathogenesis, and potential targets for treatment of PTOA in the ankle joint. Previous reviews primarily addressed clinical approaches to ankle PTOA, while the focus of the current article will be specifically on the newly acquired knowledge of the cellular mechanisms that drive PTOA in the ankle joint and means for potential targeted therapeutics that might halt the progression of cartilage degeneration and/or improve the outcome of surgical interventions...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27994715/ankle-cartilage-repair
#9
EDITORIAL
Stefan Nehrer, Francesca Vannini
No abstract text is available yet for this article.
January 2017: Cartilage
https://www.readbyqxmd.com/read/27688846/modulation-of-superficial-zone-protein-lubricin-prg4-by-kartogenin-and-transforming-growth-factor-%C3%AE-1-in-surface-zone-chondrocytes-in-bovine-articular-cartilage
#10
Kazumasa Miyatake, Kenjiro Iwasa, Sean M McNary, Gordon Peng, A Hari Reddi
OBJECTIVE: Superficial zone protein (SZP)/lubricin/PRG4 functions as a boundary lubricant in articular cartilage to decrease friction and wear. As articular cartilage lubrication is critical for normal joint function, the accumulation of SZP at the surface of cartilage is important for joint homeostasis. Recently, a heterocyclic compound called kartogenin (KGN) was found to induce chondrogenic differentiation and enhance mRNA expression of lubricin. The objective of this study was to determine whether KGN can stimulate synthesis of SZP in superficial zone, articular chondrocytes...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688845/the-chondroprotective-role-of-erythromycin-in-a-murine-joint-destruction-model
#11
Tomoya Uchimura, Andrea T Foote, David C Markel, Weiping Ren, Li Zeng
OBJECTIVE: Inflammation is a major player in the joint destruction process. Macrolide antibiotics have recently been found to have a novel anti-inflammatory function, but their effects on the joint are unknown. Our objective was to investigate the effect of macrolide antibiotic erythromycin on cartilage gene expression under inflammatory conditions as well as on joint pathology in an in vivo inflammatory joint destruction model. DESIGN: In our in vivo studies, mouse knee joints were injected with monosodium iodoacetate (MIA), a chemical that inhibits glycolysis and causes joint inflammation and matrix loss...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688844/transplantation-of-scaffold-free-cartilage-like-cell-sheets-made-from-human-bone-marrow-mesenchymal-stem-cells-for-cartilage-repair-a-preclinical-study
#12
Maki Itokazu, Shigeyuki Wakitani, Hisashi Mera, Yoshihiro Tamamura, Yasushi Sato, Mutsumi Takagi, Hiroaki Nakamura
OBJECTIVE: The object of this study was to determine culture conditions that create stable scaffold-free cartilage-like cell-sheets from human bone marrow-derived mesenchymal stem cells (hBMSCs) and to assess their effects after transplantation into osteochondral defects in nude rats. DESIGN: (Experiment 1) The hBMSCs were harvested from 3 males, the proliferative and chondrogenic capacities were assessed at passage 1, and the cells were expanded in 3 different culture conditions: (1) 5% fetal bovine serum (FBS), (2) 10% FBS, and (3) 5% FBS with fibroblast growth factor 2 (FGF-2)...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688843/bilayer-implants-electromechanical-assessment-of-regenerated-articular-cartilage-in-a-sheep-model
#13
Jan C Schagemann, Nicola Rudert, Michelle E Taylor, Sotcheadt Sim, Eric Quenneville, Martin Garon, Mathias Klinger, Michael D Buschmann, Hagen Mittelstaedt
OBJECTIVE: To compare the regenerative capacity of 2 distinct bilayer implants for the restoration of osteochondral defects in a preliminary sheep model. METHODS: Critical sized osteochondral defects were treated with a novel biomimetic poly-ε-caprolactone (PCL) implant (Treatment No. 2; n = 6) or a combination of Chondro-Gide and Orthoss (Treatment No. 1; n = 6). At 19 months postoperation, repair tissue (n = 5 each) was analyzed for histology and biochemistry...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688842/expression-of-tgf-%C3%AE-signaling-regulator-rbpms-rna-binding-protein-with-multiple-splicing-is-regulated-by-il-1%C3%AE-and-tgf-%C3%AE-superfamily-members-and-decreased-in-aged-and-osteoarthritic-cartilage
#14
S Shanmugaapriya, A van Caam, L de Kroon, Elly L Vitters, B Walgreen, H van Beuningen, E Blaney Davidson, Peter M van der Kraan
OBJECTIVE: RNA-binding protein with multiple splicing (RBPMS) has been shown to physically interact with Smads and enhance transforming growth factor-β (TGF-β)-mediated Smad2/3 transcriptional activity in mammalian cells. Objective of this study was to examine whether expression of RBPMS is regulated by interleukin-1β (IL)-1β and TGF-β superfamily growth factors and whether expression of RBPMS is altered during aging and experimental osteoarthritis. METHODS: Expression of RBPMS protein was investigated in chondrocyte cell lines of murine (H4) and human (G6) origin using Western blot analysis...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688841/safety-of-repeated-injections-of-sodium-hyaluronate-supartz-for-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#15
Raveendhara R Bannuru, Christopher R Brodie, Matthew C Sullivan, Timothy E McAlindon
OBJECTIVE: Though there is no consensus on its efficacy, knee osteoarthritis is symptomatically managed with intra-articular hyaluronic acid (IAHA). Recent reports suggest that IAHA may delay the need for total knee replacement, with the magnitude of delay proportional to the number of injection series. However, the safety of repeated injection series is reported to vary between commercial products. This report describes a systematic review of safety data on repeated treatment courses of SUPARTZ...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688840/acute-delamination-of-commercially-available-decellularized-osteochondral-allograft-plugs-a-report-of-two-cases
#16
Ryan M Degen, Danielle Tetreault, Greg T Mahony, Riley J Williams
Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recent years. This case report describes 2 cases of acute failure following the use of commercially available osteochondral allograft plugs used for the treatment of osteochondral defects of the distal femur...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688839/matrix-associated-autologous-chondrocyte-implantation-a-clinical-follow-up-at-15-years
#17
Justus Gille, Peter Behrens, Arndt Peter Schulz, Ralf Oheim, Benjamin Kienast
INTRODUCTION: A prospective clinical investigation was carried out in order to clarify whether Matrix-associated autologous chondrocyte implantation (MACI) results in clinical improvement at long-term follow-up. HYPOTHESIS: MACI will result in clinical improvement at long-term follow-up. STUDY DESIGN: Case series; level of evidence, 4. METHODS: Thirty-eight patients were treated with MACI. These patients were evaluated for up to a mean of 16 years (range 15-17 years) after the intervention...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688838/long-term-outcomes-after-autologous-chondrocyte-implantation-a-systematic-review-at-mean-follow-up-of-11-4-years
#18
Ayoosh Pareek, James L Carey, Patrick J Reardon, Lars Peterson, Michael J Stuart, Aaron J Krych
OBJECTIVE: Autologous chondrocyte implantation (ACI) has not been proven to be durable over the long-term. The purpose of this systematic review was (1) to evaluate activity level and knee function, (2) to evaluate reoperation and failure rates, and (3) to analyze risk factors for reoperation and failure of ACI at minimum long-term follow-up. DESIGN: A comprehensive review was performed for studies with long-term outcomes after ACI for cartilage defect repair. Studies reported outcome scores such as Tegner score, Lysholm score, and International Knee Documentation Society (IKDC) score along with rates of failure and reoperation...
October 2016: Cartilage
https://www.readbyqxmd.com/read/27688837/the-first-study-of-cartilage-by-magnetic-resonance-a-historical-account
#19
Yang Xia, Peter Stilbs
OBJECTIVE: To recap the historical journey leading to the first cartilage research article using nuclear magnetic resonance (NMR), published in 1955 by 2 Swedish researchers, Erik Odeblad and Gunnar Lindström. DESIGN: Extensive Internet search utilizing both English and Swedish websites, and reading the dissertations available at the Royal Institute of Technology (Stockholm, Sweden) and via interlibrary loans at Oakland University (Michigan, USA). RESULTS: Using a primitive NMR instrument that Lindström built for his graduate research at the Nobel Institute for Physics (Stockholm, Sweden), Odeblad and Lindström studied the characteristics of the NMR signal in calf cartilage...
October 2016: Cartilage
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#20
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
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