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Cartilage

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https://www.readbyqxmd.com/read/28425303/a-retrospective-study-assessing-safety-and-efficacy-of-bipolar-radiofrequency-ablation-for-knee-chondral-lesions
#1
Monther Gharaibeh, Andras Szomor, Darren B Chen, Samuel J MacDessi
OBJECTIVE: Bipolar radiofrequency (bRF) ablation is gaining popularity as a treatment modality for unstable knee chondral lesions of the knee. Limited reports of osteonecrosis and chondrolysis have been published; however, there is little data examining the safety of this treatment in larger series. This study aims to evaluate the safety and efficacy of bRF in the treatment of chondral lesions encountered during knee arthroscopy. DESIGN: A retrospective evaluation of adverse outcomes in patients that underwent treatment of chondral lesions using bRF was undertaken...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28399641/optimization-of-degradation-profile-for-new-scaffold-in-cartilage-repair
#2
Sarav S Shah, Haixiang Liang, Sandeep Pandit, Zalak Parikh, John A Schwartz, Todd Goldstein, Lawrence P Lavelle, Arindam Datta, Daniel A Grande
Objective To establish whether a novel biomaterial scaffold with tunable degradation profile will aid in cartilage repair of chondral defects versus microfracture alone in vitro and in a rat model in vivo. Design In vitro-Short- and long-term degradation scaffolds were seeded with culture expanded articular chondrocytes or bone marrow mesenchymal stem cells. Cell growth and differentiation were evaluated with cell morphological studies and gene expression studies. In vivo-A microfracture rat model was used in this study to evaluate the repair of cartilage and subchondral bone with the contralateral knee serving as the empty control...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28397530/comparison-of-fixation-techniques-of-3d-woven-poly-%C3%AF%C2%B5-caprolactone-scaffolds-for-cartilage-repair-in-a-weightbearing-porcine-large-animal-model
#3
James M Friedman, Mackenzie L Sennett, Marcelo B Bonadio, Kerry O Orji, Alexander L Neuwirth, Niobra Keah, James L Carey, Franklin T Moutos, Bradley T Estes, Farshid Guilak, Henning Madry, Robert L Mauck, George R Dodge
Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared including total arthrotomy (traditional) and a retinaculum-sparing, minimally invasive surgery (MIS) approach. Following microfracture (MFX), scaffolds were placed without fixation or were fixed with fibrin glue, suture, or subchondral anchor...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28397529/controlling-abnormal-joint-movement-inhibits-response-of-osteophyte-formation
#4
Kenji Murata, Takanori Kokubun, Yuri Morishita, Katsuya Onitsuka, Shuhei Fujiwara, Aya Nakajima, Tsutomu Fujino, Kiyomi Takayanagi, Naohiko Kanemura
Objective Osteoarthritis (OA) is induced by accumulated mechanical stress to joints; however, little has been reported regarding the cause among detailed mechanical stress on cartilage degeneration. This study investigated the influence of the control of abnormal joint movement induced by anterior cruciate ligament (ACL) injury in the articular cartilage. Design The animals were divided into 3 experimental groups: CAJM group ( n = 22: controlling abnormal joint movement), ACL-T group ( n = 22: ACL transection or knee anterior instability increased), and INTACT group ( n = 12: no surgery)...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28393540/microfracture-state-of-the-art-in-cartilage-surgery
#5
Florian Frehner, Jan P Benthien
Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication quality has risen in orthopaedic sports medicine recently. Therefore, we think it is necessary to evaluate recent clinical trials being rated for their evidence-based medicine (EBM) quality. We also compared the mean impact factor of the journals publishing the different studies as an indicator of the study's citation and evaluated for a change over the studied time frame...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28393539/autologous-bone-marrow-cell-stimulation-and-allogenic-chondrocyte-implantation-for-the-repair-of-full-thickness-articular-cartilage-defects-in-a-rabbit-model
#6
Sungwook Choi, Gyeong Min Kim, Young Hee Maeng, Hyunseong Kang, Chen Tai Teong, Emily E Lee, Seung Jin Yoo, Darryl D Dlima, Myung Ku Kim
OBJECTIVE: The aim of this study was to evaluate the results of autologous bone marrow cell stimulation and allogenic chondrocyte implantation using 3-dimensional gel-type fibrin matrix in an animal model. DESIGN: Eighteen rabbits were divided into 2 treatment groups. One group was treated with a microfracture and covering of it with gel-type fibrin (AutoBMS; n = 9), and the other group was treated with allogenic chondrocytes mixed gel-type fibrin at the cartilage defect (AlloCI; n = 9)...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28357919/simple-silica-column-based-method-to-quantify-inorganic-polyphosphates-in-cartilage-and-other-tissues
#7
Whitaik David Lee, Rahul Gawri, Toshikazu Shiba, Ae-Ri Ji, William L Stanford, Rita A Kandel
OBJECTIVE: Inorganic polyphosphates (polyP) play a multitude of roles in mammalian biology. PolyP research is hindered by the lack of a simple and sensitive quantification method. The aim of this study was to develop a robust method for quantifying the low levels of polyP in mammalian tissue such as cartilage, which is rich in macromolecules that interfere with its determination. DESIGN: Native and in vitro formed tissues were digested with proteinase K to release sequestrated polyP...
March 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28345415/chondrogenic-gene-expression-differences-between-chondrocytes-from-osteoarthritic-and-non-oa-trauma-joints-in-a-3d-collagen-type-i-hydrogel
#8
Vivek Jeyakumar, Florian Halbwirth, Eugenia Niculescu-Morzsa, Christoph Bauer, Hannes Zwickl, Daniela Kern, Stefan Nehrer
Objective The purpose of the current study was to compare the donor age variation of chondrocytes from non-OA (osteoarthritic) trauma joints in patients of young to middle age (20.5 ± 3.7, 31.8 ± 1.9, 41.9 ± 4.1 years) embedded in matrix-associated autologous chondrocyte transplantation (MACT) grafts (CaReS). The chondrocyte-specific gene expression of CaReS grafts were then compared to chondrocytes from OA joints (in patients aged 63.8 ± 10 years) embedded in a collagen type I hydrogel. Design OA chondrocytes and articular chondrocyte-laden grafts were cultured over 14 days in chondrogenic growth medium...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345414/fresh-osteochondral-allograft-transplantation-for-fractures-of-the-knee
#9
Guilherme C Gracitelli, Luis Eduardo Passarelli Tirico, Julie C McCauley, Pamela A Pulido, William D Bugbee
Objective The purpose of this study was to evaluate functional outcomes and allograft survivorship among patients with knee fracture who underwent fresh osteochondral allograft (OCA) transplantation as a salvage treatment option. Design Retrospective analysis of prospectively collected data. Setting Department of Orthopaedic Surgery at one hospital. Patients Fresh OCAs were implanted for osteochondral lesions after knee fracture in 24 males and 15 females with an average age of 34 years. Twenty-nine lesions (74%) were tibial plateau fractures, 6 (15%) were femoral condyle fractures, and 4 (10%) were patella fractures...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345413/development-of-a-tool-to-predict-outcome-of-autologous-chondrocyte-implantation
#10
M Naomi Dugard, Jan Herman Kuiper, Jane Parker, Sally Roberts, Eric Robinson, Paul Harrison, James B Richardson
Objective The study had 2 objectives: first, to evaluate the success of autologous chondrocyte implantation (ACI) in terms of incidence of surgical re-intervention, including arthroplasty, and investigate predictors of successful treatment outcome. The second objective was to derive a tool predicting a patient's arthroplasty risk following ACI. Design In this Level II, prognostic study, 170 ACI-treated patients (110 males [aged 36.8 ± 9.4 years]; 60 females [aged 38.1 ± 10.2 years]) completed a questionnaire about further surgery on their knee treated with ACI 10...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345412/effect-of-glucosamine-sulfate-on-osteoarthritis-in-the-cruciate-deficient-canine-model-of-osteoarthritis
#11
Wolfram Wenz, Christian Hornung, Christopher Cramer, Malte Schroeder, Michael Hoffmann
Objective Osteoarthritis (OA) is a major cause of musculoskeletal pain and disability worldwide. The investigation of disease-modifying treatment options for OA has become an important aspect of orthopedic care. To assess the effect of intra-articular and oral glucosamine sulfate (GS) versus placebo on osteoarthritis in a canine model. Materials In this randomized, placebo-controlled, double-blinded study, OA was induced by anterior cruciate ligament transection (ACLT) according to the Pond-Nuki model in 32 canines...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345411/corrigendum-to-depth-dependent-glycosaminoglycan-concentration-in-articular-cartilage-by-quantitative-contrast-enhanced-micro-computed-tomography
#12
(no author information available yet)
Owing to the errors made by the authors, Mittelstaedt D and Xia Y, the following article contains error. Mittelstaedt D, Xia Y. Depth-Dependent Glycosaminoglycan Concentration in Articular Cartilage by Quantitative Contrast-Enhanced Micro-Computed Tomography. Cartilage. 2015;6:216-25. Original doi: 10.1177/1947603515596418.
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345410/transplantation-of-chemically-processed-decellularized-meniscal-allografts
#13
Kolja Gelse, Ludwig Körber, Martin Schöne, Kay Raum, Peter Koch, Milena Pachowsky, Götz Welsch, Roman Breiter
Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts were transplanted into the knee joints of sheep that were treated by lateral meniscectomy. Joints treated by meniscectomy only and untreated joints served as controls. The joints were analyzed morphologically 6 and 26 weeks after surgery by the macroscopical and histological OARSI (Osteoarthritis Research Society International) score...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345409/osteoarthritis-in-football
#14
Gian M Salzmann, Stefan Preiss, Marcy Zenobi-Wong, Laurent P Harder, Dirk Maier, Jirí Dvorák
Football is currently the most popular sporting activity in the world. Multiple reports have shown that a high incidence of osteoarthritis is found in football players. Evidence clearly shows that traumatic injury significantly predisposes players for such pathophysiology. Injuries are frequent in amateur as well as professional football players, with knee and ankle accounting for the most severe injuries. Many professional athletes lose playing time due to injuries and many are forced into early retirement...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345408/autologous-chondrocyte-implantation-to-isolated-patella-cartilage-defects
#15
Arvind von Keudell, Roger Han, Tim Bryant, Tom Minas
Background Autologous chondrocyte implantation (ACI) is a durable treatment for patients with chondral defects. This study presents the comprehensive evaluation of patients with patella defects treated with ACI at medium- to long-term follow-up. Methods Thirty consecutive patients with isolated chondral lesions of the patella were enrolled prospectively. Primary outcome measures were validated patient reported outcome measures and objective magnetic resonance imaging. Results Nineteen of 30 patients underwent tibial tubercle osteotomy (TTO) to correct lateral maltracking in combination with soft tissue balancing...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345407/knee-menisci
#16
James Kevin Bryceland, Andrew John Powell, Thomas Nunn
The menisci of the knees are semicircular fibrocartilaginous structures consisting of a hydrophilic extracellular matrix containing a network of collagen fibers, glycoproteins, and proteoglycans maintained by a cellular component. The menisci are responsible for more than 50% of load transmission across the knee and increase joint congruity thereby also aiding in fluid film lubrication of the joint. In the United Kingdom, meniscal tears are the most common form of intra-articular knee injury and one of the commonest indications for orthopedic intervention...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345406/evaluation-of-the-quality-accuracy-and-readability-of-online-patient-resources-for-the-management-of-articular-cartilage-defects
#17
Dean Wang, Rohit G Jayakar, Natalie L Leong, Michael P Leathers, Riley J Williams, Kristofer J Jones
Objective Patients commonly use the Internet to obtain their health-related information. The purpose of this study was to investigate the quality, accuracy, and readability of online patient resources for the management of articular cartilage defects. Design Three search terms ("cartilage defect," "cartilage damage," "cartilage injury") were entered into 3 Internet search engines (Google, Bing, Yahoo). The first 25 websites from each search were collected and reviewed. The quality and accuracy of online information were independently evaluated by 3 reviewers using predetermined scoring criteria...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345405/thickness-distribution-of-glenohumeral-joint-cartilage
#18
Christoph Schleich, Bernd Bittersohl, Gerald Antoch, Rüdiger Krauspe, Christoph Zilkens, Jörn Kircher
High-resolution 3-dimensional cartilage-specific magnetic resonance imaging (MRI) was performed at 3 T to test the following hypotheses: (1) there is a nonuniform cartilage thickness distribution both on the proximal humerus and on the glenoid surface and (2) the glenohumeral joint as a combined system is congruent with the level of the joint cartilage surface without substantial radial mismatch. Inclusion of 38 volunteers (19 females, mean age 24.34 ± 2.22 years; range 21-29 years) in a prospective study...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345404/are-bone-bruise-characteristics-and-articular-cartilage-pathology-associated-with-inferior-outcomes-2-and-6-years-after-anterior-cruciate-ligament-reconstruction
#19
Christian Lattermann, Cale A Jacobs, Emily K Reinke, Erica A Scaramuzza, Laura J Huston, Warren R Dunn, Kurt P Spindler
Objective To determine (1) if bone bruise characteristics seen on magnetic resonance imaging are associated with patient-reported outcomes prior to and following anterior cruciate ligament reconstruction and (2) if the combined presence of bone bruises with articular cartilage pathology results in inferior 2- or 6-year outcomes. Design Bone bruise volume and severity were measured on 81 patients' preoperative magnetic resonance imaging in the medial and lateral femoral condyle (MFC, LFC) and medial and lateral tibial plateau (MTP, LTP) using the Costa-Paz classification and a modified version of Roemer and Bohndorf's technique...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28345403/intralesional-osteophyte-regrowth-following-autologous-chondrocyte-implantation-after-previous-treatment-with-marrow-stimulation-technique
#20
Marco Kawamura Demange, Tom Minas, Arvind von Keudell, Sonal Sodha, Tim Bryant, Andreas H Gomoll
Objective Bone marrow stimulation surgeries are frequent in the treatment of cartilage lesions. Autologous chondrocyte implantation (ACI) may be performed after failed microfracture surgery. Alterations to subchondral bone as intralesional osteophytes are commonly seen after previous microfracture and removed during ACI. There have been no reports on potential recurrence. Our purpose was to evaluate the incidence of intralesional osteophyte development in 2 cohorts: existing intralesional osteophytes and without intralesional osteophytes at the time of ACI...
April 2017: Cartilage
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