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Gergo Merkely, Tom Minas, Takahiro Ogura, Jakob Ackermann, Alexandre Barbieri Mestriner, Andreas H Gomoll
OBJECTIVE: Takedown of the anterior meniscus to facilitate exposure of the cartilage defects located on the tibial plateau and/or posterior femoral condyle with subsequent reattachment is being performed clinically; however, clinical evidence is lacking to support the safety of this technique. The aim of this study was therefore to investigate whether meniscal extrusion develops after patients undergo meniscus takedown and transosseous refixation during autologous chondrocyte implantation (ACI)...
October 31, 2018: Cartilage
Bryan Michael Saltzman, Michael L Redondo, Adam Beer, Eric J Cotter, Rachel M Frank, Adam B Yanke, Brian J Cole
BACKGROUND: The management of complex cartilage pathology in young, otherwise healthy patients can be difficult. PURPOSE: To determine the nature of the design, endpoints chosen, and rate at which the endpoints were met in published studies and ongoing clinical trials that investigate cartilage repair and restoration procedures. STUDY DESIGN: Systematic review. METHODS: A systematic review of the publicly available level I/II literature and of the publicly listed clinical trials regarding cartilage repair and restoration procedures for the knee was conducted adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
October 31, 2018: Cartilage
Samuel Early, Luís E P Tírico, Pamela A Pulido, Julie C McCauley, William D Bugbee
OBJECTIVE: No studies currently exist with long-term follow-up of use of osteochondral allografting (OCA) for treatment of steroid-associated osteonecrosis of femoral condyles in young, active patients who wish to avoid total knee arthroplasty (TKA). We evaluate the extent to which fresh osteochondral allografts can (1) prevent or postpone need for prosthetic arthroplasty and (2) maintain long-term clinically meaningful decrease in pain and improvement in function at mean 11-year follow-up...
October 31, 2018: Cartilage
Yang Wu, Patrick Kennedy, Nicholas Bonazza, Yin Yu, Aman Dhawan, Ibrahim Ozbolat
OBJECTIVE: Treatment of chondral injury is clinically challenging. Available chondral repair/regeneration techniques have significant shortcomings. A viable and durable tissue engineering strategy for articular cartilage repair remains an unmet need. Our objective was to systematically evaluate the published data on bioprinted articular cartilage with regards to scaffold-based, scaffold-free and in situ cartilage bioprinting. DESIGN: We performed a systematic review of studies using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
October 29, 2018: Cartilage
Thomas J A van Schaik, Florian Gaul, Erik W Dorthé, Emily E Lee, Shawn P Grogan, Darryl D D'Lima
OBJECTIVE: Mouse models are commonly used in research applications due to the relatively low cost, highly characterized strains, as well as the availability of many genetically modified phenotypes. In this study, we characterized an ex vivo murine osteochondral repair model using human infrapatellar fat pad (IPFP) progenitor cells. DESIGN: Femurs from euthanized mice were removed and clamped in a custom multidirectional vise to create cylindrical osteochondral defects 0...
October 29, 2018: Cartilage
Julio Granados-Montiel, Monica Cruz-Lemini, Claudia Rangel-Escareño, Gabriela Martinez-Nava, Carlos Landa-Solis, Ricardo Gomez-Garcia, Alberto Lopez-Reyes, Alejandro Espinosa-Gutierrez, Clemente Ibarra
OBJECTIVE: Human mesenchymal stem cells (hMSCs) are a promising source for regenerative medicine, especially mesodermal lineages. Clinical applications require an understanding of the mechanisms for transcriptional control to maintain the desired cell type. The aim of this study was to identify novel markers for differentiation of hMSCs into bone or cartilage with the use of Kartogenin, by RNA analysis using microarray technology, and explore the role of RhoA-Rho associated protein kinase (ROCK) inhibition in these...
October 29, 2018: Cartilage
Michael-Alexander Malahias, Leonidas Roumeliotis, Vasileios S Nikolaou, Efstathios Chronopoulos, Ioannis Sourlas, Georgios C Babis
Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A prospective, randomized, blind, controlled, clinical trial of 33 patients with clinical and radiographic osteoarthritis of the TMJ (grades: I-III according to the Eaton and Littler classification) was conducted...
October 20, 2018: Cartilage
Yusuke Tsuyuguchi, Tomoyuki Nakasa, Masakazu Ishikawa, Shigeru Miyaki, Ryosuke Matsushita, Munekazu Kanemitsu, Nobuo Adachi
Objective Autologous chondrocyte implantation is a necessary procedure for the repair of articular cartilage defects; however, isolated chondrocyte implantation requires a 2-step procedure (for harvesting and implantation) and is limited by cytotoxicity due to enzymatic digestion. Therefore, in this in vitro study, we evaluated the possible benefit of using minced cartilage embedded in a 3-dimensional culture scaffold and fixed with fibrin glue, in comparison with isolated chondrocytes in atelocollagen, to induce cell migration, proliferation, and matrix production, using cartilage from patients with knee joint osteoarthritis...
October 12, 2018: Cartilage
Qidong Zhang, Wanshou Guo, Yan Chen, Qichao Zhao, Zhaohui Liu, Weiguo Wang
Objective Hip cartilage quality is essential for the success of joint-preserving surgery for osteonecrosis. This study aimed to characterize cartilage changes in osteonecrosis of femoral head (ONFH) using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). Design Fifteen asymptomatic (control) and 60 ONFH subjects were included in this study. The ONFH subjects were stratified in accordance with the Association Research Circulation Osseous (ARCO) classification ( n = 15 hips per ARCO stage)...
October 3, 2018: Cartilage
Matthew T Wolf, Hong Zhang, Blanka Sharma, Norman A Marcus, Uwe Pietzner, Stefan Fickert, Achim Lueth, G H Robert Albers, Jennifer H Elisseeff
Objective To determine performance and repair kinetics of the ChonDux hydrogel scaffold for treating focal articular cartilage defects in the knee over 24 months. Design This assessor-blinded trial evaluates ChonDux hydrogel scaffold implantation in combination with microfracture in 18 patients across 6 sites. Male and female patients 18 to 65 years of age with full-thickness femoral condyle defects 2 to 4 cm2 in area were enrolled. Eligible patients received ChonDux treatment followed by rehabilitation. Defect volume fill was evaluated after 3, 6 (primary outcome), 12, 18, and 24 months by assessor blinded magnetic resonance imaging (MRI) analysis...
October 3, 2018: Cartilage
Nikolai P Omelyanenko, Pavel A Karalkin, Elena A Bulanova, Elizaveta V Koudan, Vladislav A Parfenov, Sergei A Rodionov, Alisa D Knyazeva, Vladimir A Kasyanov, Igor I Babichenko, Tamara Z Chkadua, Yusef D Khesuani, Anna A Gryadunova, Vladimir A Mironov
Objective Chondrospheres represent a variant of tissue spheroids biofabricated from chondrocytes. They are already being used in clinical trials for cartilage repair; however, their biomechanical properties have not been systematically investigated yet. The aim of our study was to characterize chondrospheres in long-term in vitro culture conditions for morphometric changes, biomechanical integrity, and their fusion and spreading kinetics. Results It has been demonstrated that the increase in chondrospheres secant modulus of elasticity is strongly associated with the synthesis and accumulation of extracellular matrix...
September 15, 2018: Cartilage
HongBin Cheng, Baoxi Hao, Jingtao Sun, Mingxi Yin
Background C-terminal cross-linked telopeptides of type II collagen (CTX-II) are one of the most frequently assessed markers for osteoarthritis (OA) diagnosis. The aim of this meta-analysis was to confirm the diagnostic value of urinary CTX-II in knee OA. Materials and Methods PubMed, ScienceDirect, and EMBASE were searched for studies measured urinary CTX-II in patients with knee OA and in healthy controls. Urinary CTX-II levels were compared between knee OA patients and controls. Differences between groups were expressed as standardized mean differences (SMD) when individual outcomes were measured with different scales...
September 15, 2018: Cartilage
Fabian Blanke, Andreas Feitenhansl, Maximilian Haenle, Stephan Vogt
Objective The etiology of osteochondritis dissecans (OCD) is still uncertain. Recently, it has been hypothesized that instability of the anterior horn of the meniscus is an important cause for the development of a nontraumatic OCD in adolescents with good results after surgical stabilization. This case series aims to evaluate the treatment results after meniscus stabilization in adults with nontraumatic OCD. Design Ten patients with magnetic resonance imaging (MRI)-confirmed OCD of the knee joint, meniscal instability, and closed epiphyseal plates were enrolled in this study...
September 15, 2018: Cartilage
Takahiro Ogura, Jakob Ackermann, Alexandre Barbieri Mestriner, Gergo Merkely, Andreas H Gomoll
Objective We sought to determine the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) associated with the Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Lysholm, and Short Form-12 (SF-12) after autologous chondrocyte implantation (ACI). Design Ninety-two patients with satisfaction surveys at a minimum of 2 years postoperatively and at least 1 repeated patient-reported outcome measure (PROM) were analysed...
September 15, 2018: Cartilage
Arne Van de Vyver, Stefan Clockaerts, Chris H A van de Lest, Wu Wei, Jan Verhaar, Gerjo J V M Van Osch, Yvonne M Bastiaansen-Jenniskens
Objective Free fatty acids (FAs) may influence cartilage metabolism and osteoarthritis (OA) disease progression. It is not clearly studied which FAs are present in the synovial fluid of knee joints and whether there are differences in FA content between nonsymptomatic and OA knee joints. The aim of this study was to investigate the presence of different types of FAs in synovial fluid of both OA- and nonsymptomatic control joints, and to analyze differences between both groups. Design A total of 23 synovial fluid samples were collected from patients with end-stage knee OA undergoing total knee replacement, with approval of the medical ethical committee...
September 11, 2018: Cartilage
Eric J Cotter, Anirudh K Gowd, Daniel D Bohl, Alan Getgood, Brian J Cole, Rachel M Frank
Objective To characterize rates and risk factors for adverse events following distal femoral osteotomy (DFO), high tibial osteotomy (HTO), and tibial tubercle osteotomy (TTO) procedures. Design Patients undergoing DFO, HTO, or TTO procedures during 2005 to 2016 were identified in the American College of Surgeons National Surgical Quality Improvement Program. Rates of adverse events were characterized for each procedure. Demographic, comorbidity, and procedural factors were tested for association with occurrence of any adverse events...
September 6, 2018: Cartilage
Cheryl L S Liu, Andrew C Hall
Objective Septic arthritis is commonly caused by Staphylococcus aureus and is a medical emergency requiring antibiotics and joint irrigation. The bacteria produce α-toxin causing rapid cartilage cell ( chondrocyte) death. Saline (0.9%NaCl) lavage is normally used to remove bacteria and toxins, however, its composition might be suboptimal to suppress the lethal effects of α-toxin. We utilized rabbit erythrocyte hemolysis as a sensitive, biologically relevant assay of α-toxin levels to determine if changes to osmolarity, temperature, pH, and divalent cation (Mg2+ , Ca2+ ) concentration were protective...
September 6, 2018: Cartilage
Muhammad Farooq Rai, Linda J Sandell, Toby N Barrack, Lei Cai, Eric D Tycksen, Simon Y Tang, Matthew J Silva, Robert L Barrack
Objective To query the transcript-level changes in the medial and lateral tibial plateau cartilage in tandem with obesity in patients with end-stage osteoarthritis (OA). Design Cartilage was obtained from 23 patients (20 obese [body mass index > 30 kg/m2 ], 3 overweight [body mass index < 30 kg/m2 ]) at the time of total knee replacement. Cartilage integrity was assessed using Outerbridge scale, while radiographic changes were scored on preoperative X-rays using Kellgren-Lawrence (K-L) classification...
September 3, 2018: Cartilage
Raffy Mirzayan, Michael D Charles, Michael Batech, Brian D Suh, David DeWitt
Objective To evaluate clinical, functional, and radiographic outcomes of patients who underwent bipolar osteochondral allograft transplantation (OCAT) of the patellofemoral joint (PFJ). Design Prospectively collected data on 18 knees who underwent fresh osteochondral allograft transplantation of the patella and trochlea by a single surgeon were reviewed. Inclusion criteria were: high-grade chondral lesions of PFJ (5 knees), or recurrent patella dislocations with trochlear dysplasia and chondral injury to the patella and/or trochlea (13 knees)...
September 3, 2018: Cartilage
Shane A Shapiro, Jennifer R Arthurs, Michael G Heckman, Joseph M Bestic, Shari E Kazmerchak, Nancy N Diehl, Abba C Zubair, Mary I O'Connor
Objective Bone marrow aspiration and concentration (BMAC) is becoming a more common regenerative therapy for musculoskeletal pathology. In our current pilot study, we studied patients with mild-to-moderate bilateral knee osteoarthritis, compared pain at 12-month follow-up between BMAC-injected and saline-injected knees, and examined cartilage appearance measured by magnetic resonance imaging (MRI) T2 quantitative mapping. Design Twenty-five patients with mild-to-moderate bilateral osteoarthritic knee pain were randomized to receive BMAC into one knee and saline placebo into the other...
August 30, 2018: Cartilage
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