journal
https://read.qxmd.com/read/38525935/intra-articular-injection-of-interleukin-8-neutralizing-monoclonal-antibody-effectively-attenuates-osteoarthritis-progression-in-rabbits
#1
JOURNAL ARTICLE
Junjun Yang, Xin Wang, Yingbo Zhang, Rui He, Zhenlan Fu, Rong Wang, Yanming Ma, Dejie Fu, Shuo Meng, Wang Cai, Yizhao Zhou, Cheng Chen, Guangxing Chen, Xiaoyuan Gong
OBJECTIVE: Cytokines are implicated in the pathogenesis of osteoarthritis (OA), and this study aims to assess the therapeutic potential of an IL-8 neutralizing monoclonal antibody (mAb) for OA intervention. DESIGN: The study employed a rabbit model of OA induced by anterior cruciate ligament transection (ACLT) surgery to investigate the effects of an interleukin (IL)-8 neutralizing mAb, with hyaluronic acid (HA) used as a positive control. Primary outcomes assessed in the rabbits included cartilage repair, synovitis, joint effusion, changes in footprints, and lower limb loading conditions...
March 25, 2024: Cartilage
https://read.qxmd.com/read/38506486/evidence-based-update-on-the-surgical-technique-and-clinical-outcomes-of-retrograde-drilling-a-systematic-review
#2
JOURNAL ARTICLE
Youichi Yasui, Wataru Miyamoto, Yoshiharu Shimozono, Keisuke Tsukada, Hirotaka Kawano, Masato Takao
BACKGROUND: Retrograde drilling is an established surgical technique to treat osteochondral lesions of the talus (OLT). It involves non-trans-articular drilling to induce subchondral bone revascularization and bone formation without damaging the overlying articular cartilage. The present study aimed to elucidate the heterogeneity of clinical studies on retrograde drilling for OLT. DESIGN: A systematic search of the MEDLINE, Web of Science, EMBASE, and Cochrane Library databases for studies published between January 1996 and August 27, 2022, was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by two independent reviewers...
March 20, 2024: Cartilage
https://read.qxmd.com/read/38501741/hydrogel-based-matrix-associated-autologous-chondrocyte-implantation-shows-greater-substantial-clinical-benefit-at-24-months-follow-up-than-microfracture-a-propensity-score-matched-pair-analysis
#3
JOURNAL ARTICLE
Christoph Gaissmaier, Peter Angele, Robert C Spiro, Annette Köhler, Alexandra Kirner, Philipp Niemeyer
OBJECTIVE: To compare substantial clinical benefit (SCB) of a hydrogel-based, matrix-associated autologous chondrocyte implantation (M-ACI) method versus microfracture (MFx) in the treatment of knee cartilage defects. DESIGN: Propensity score matched-pair analysis, using the MFx control group of a phase III study as comparator for M-ACI treatment in a single-arm phase III study, resulting in 144 patients in the matched-pair set. RESULTS: Groups were comparable regarding baseline Knee Injury and Osteoarthritis Outcome Score (KOOS), sex, age, body mass index, symptom duration, smoking status, and previous knee surgeries...
March 19, 2024: Cartilage
https://read.qxmd.com/read/38501739/the-bmp7-derived-peptide-p-63-82-reduces-cartilage-degeneration-in-the-rat-aclt-pmmx-model-for-posttraumatic-osteoarthritis
#4
JOURNAL ARTICLE
Ellen G J Ripmeester, Jessica S J J Steijns, Karolina A P Wijnands, Roderick H M J Stassen, Vasek Pitelka, Laura C W Peeters, Andy Cremers, Nzekui M S A Astryde, Alzbeta Chabronova, Don A M Surtel, Pieter J Emans, Guus G H van den Akker, Bert van Rietbergen, Lodewijk W van Rhijn, Marjolein M J Caron, Tim J M Welting
OBJECTIVE: Osteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx])...
March 19, 2024: Cartilage
https://read.qxmd.com/read/38501456/arthroscopic-implantation-of-a-cell-free-bilayer-scaffold-for-the-treatment-of-knee-chondral-lesions-a-2-year-prospective-study
#5
JOURNAL ARTICLE
Rimtautas Gudas, Mantas Staškūnas, Justinas Mačiulaitis, Emilė Gudaitė, Ieva Aleknaite-Dambrauskiene
OBJECTIVE: The main objective of this study is to assess the safety and clinical efficacy of a cell-free bilayer scaffold (MaioRegen Chondro+ by Fin-Ceramica) in patients affected by chondral knee lesions of different origin and localization. DESIGN: Thirty-one patients with focal chondral lesions of the knee were arthroscopically treated with MaioRegen Chondro+. All patients were prospectively evaluated for a minimum of 2 years using the International Knee Documentation Committee (IKDC) Questionnaire and the Tegner Activity Scale...
March 19, 2024: Cartilage
https://read.qxmd.com/read/38501455/a-traumatic-impact-immediately-changes-the-mechanical-properties-of-articular-cartilage
#6
JOURNAL ARTICLE
Robin P Blom, Danka Rahim, Erik Paardekam, Gino M M J Kerkhoffs, Davide Iannuzzi, Theodoor H Smit
OBJECTIVE: To investigate whether and how a single traumatic impact changes the mechanical properties of talar articular cartilage. DESIGN: A marble was placed on the joint surface and a weight was dropped on both medial and lateral caprine talus to create a well-defined single focal impact. The mechanical properties of intact and impacted talar cartilage were measured with a micro-indenter. Elastic (storage) and viscous (loss) moduli were determined by oscillatory ramp and dynamic mechanical analysis protocols...
March 19, 2024: Cartilage
https://read.qxmd.com/read/38439552/comparison-of-clinical-efficacy-and-mechanical-characteristics-of-two-knee-distraction-devices-with-relevance-for-clinical-practice
#7
JOURNAL ARTICLE
T Struik, M P Jansen, R G P Lafeber, F P J G Lafeber, S C Mastbergen
OBJECTIVE: Distraction treatment for severe osteoarthritis below the age of 65 successfully postpones arthroplasty. Most patients have been treated with a general external fixator or a device specifically intended for knee distraction. This study compares clinical efficacy of both devices in retrospect and their mechanical characteristics. DESIGN: Clinical efficacy 2 years posttreatment was compared using retrospective data from patients with severe knee osteoarthritis treated with knee distraction; 63 with the Dynamic Monotube (Stryker GmbH, Switzerland) and 65 with the KneeReviver (ArthroSave BV, the Netherlands)...
March 4, 2024: Cartilage
https://read.qxmd.com/read/38426452/biomechanical-comparison-of-all-suture-all-inside-meniscus-repair-devices-in-a-human-cadaveric-meniscus-model
#8
JOURNAL ARTICLE
Patrick A Massey, Wayne Scalisi, Carver Montgomery, Drayton Daily, James Robinson, Giovanni F Solitro
OBJECTIVE: Newer all-suture, all-inside meniscus repair devices utilize soft suture anchors. The purpose of this study was to compare the biomechanical performance of 4 meniscus repair devices in human cadaver menisci: the JuggerStitch (all-suture, all-inside), the FiberStitch (all-suture, all-inside), a polyether ether ketone (PEEK) all-inside, and an inside-out device. DESIGN: Forty human cadaver menisci were tested after creating 20 mm longitudinal tears in the posterior meniscus...
March 1, 2024: Cartilage
https://read.qxmd.com/read/38403983/the-statistical-fragility-of-marrow-stimulation-for-cartilage-defects-of-the-knee-a-systematic-review-of-randomized-controlled-trials
#9
JOURNAL ARTICLE
Avanish Yendluri, Ara Alexanian, Rohit R Chari, John J Corvi, Nikan K Namiri, Junho Song, Michael J Alaia, Xinning Li, Robert L Parisien
OBJECTIVE: Marrow stimulation is used to address knee cartilage defects. In this study, we used the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to evaluate statistical fragility of outcomes reported in randomized controlled trials (RCTs) evaluating marrow stimulation. DESIGN: PubMed, Embase, and MEDLINE were queried for recent RCTs (January 1, 2010-September 5, 2023) assessing marrow stimulation for cartilage defects of the knee...
February 25, 2024: Cartilage
https://read.qxmd.com/read/38366556/prognostic-factors-for-clinical-outcome-and-cartilage-regeneration-after-implantation-of-allogeneic-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-in-large-sized-cartilage-defects-with-osteoarthritis
#10
JOURNAL ARTICLE
Se-Han Jung, Min Jung, Kwangho Chung, Sungjun Kim, Jisoo Park, Junseok Hong, Chong-Hyuk Choi, Sung-Hwan Kim
OBJECTIVE: To analyze the prognostic factors for clinical outcomes and cartilage regeneration after the implantation of allogeneic human umbilical cord blood mesenchymal stem cell (hUCB-MSC) for treating large-sized cartilage defects with osteoarthritis. DESIGN: This study is a case-series with multiple subgroup analyses that divides the included patients into multiple subgroups based on various factors. Overall, 47 patients who underwent hUCB-MSC implantation were included...
February 16, 2024: Cartilage
https://read.qxmd.com/read/38366391/reporting-of-morphology-location-and-size-in-the-treatment-of-osteochondral-lesions-of-the-talus-in-11-785-patients-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Pascal R van Diepen, Frank F Smithuis, Julian J Hollander, Jari Dahmen, Kaj S Emanuel, Sjoerd A S Stufkens, Gino M M J Kerkhoffs
OBJECTIVE: Uniformity of reporting is a requisite to be able to compare results of clinical studies on the treatment of osteochondral lesions of the talus (OLT). The primary aim of this study was to evaluate the frequency and quality of reporting of size, morphology, and location of OLTs. DESIGN: A literature search was performed from 1996 to 2023 to identify clinical studies on surgical treatment of OLTs. Screening was performed by 2 reviewers, who subsequently graded the quality using the methodological index for non-randomized studies (MINORS)...
February 16, 2024: Cartilage
https://read.qxmd.com/read/38366389/hsf1-increases-eogt-mediated-glycosylation-of-notch1-to-promote-il-1%C3%AE-induced-inflammatory-injury-of-chondrocytes
#12
JOURNAL ARTICLE
Yuanchi Huang, Wenjie Pan, Huanli Bao, Xiangxiang Sun, Chao Xu, Jianbing Ma
OBJECTIVE: Osteoarthritis (OA) is the most common arthritic disease in humans. Nevertheless, the pathogenic mechanism of OA remains unclear. This study aimed to explore that heat-shock transcription factor 1 (HSF1) facilitated interleukin-1 beta (IL-1β) chondrocyte injury by increasing Notch1 O-linked N -acetylglucosamine (O-GlcNAc) modification level. DESIGN: Human chondrocytes were incubated with 5 ng/ml interleukin-1 beta (IL-1β) for 24 h to establish OA cell model...
February 16, 2024: Cartilage
https://read.qxmd.com/read/38323533/second-look-arthroscopy-shows-inferior-cartilage-after-bone-marrow-stimulation-compared-with-other-operative-techniques-for-osteochondral-lesions-of-the-talus-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Jelmer T Vreeken, Jari Dahmen, Tobias Stornebrink, Kaj S Emanuel, Alex B Walinga, Sjoerd A S Stufkens, Gino M M J Kerkhoffs
OBJECTIVE: To compare cartilage quality after different surgical interventions for osteochondral lesions of the talus (OLT), evaluated by second-look arthroscopy. Secondary aims were to report concomitant diagnoses, and to correlate cartilage quality with clinical and radiological outcomes. This review hypothesizes that the cartilage repair after bone marrow stimulation (BMS) is inferior to the other available treatment options. METHODS: PROSPERO ID: CRD42022311489...
February 7, 2024: Cartilage
https://read.qxmd.com/read/38321966/cellular-enhancement-of-frozen-meniscus-allograft-combining-native-meniscus-and-mesenchymal-stromal-cell-injections
#14
JOURNAL ARTICLE
Caroline Struijk, Katherine L Lydon, Martin Husen, Peter Verdonk, Jozef Michielsen, Andre J van Wijnen, Aaron J Krych, Daniel B F Saris
OBJECTIVE: This proof-of-concept study investigated an improved cell-based injection therapy combining mesenchymal stem cells (MSCs) and meniscus cells (MCs) to support superior meniscus allograft repopulation and early revival compared to injecting MSCs alone. DESIGN: In this controlled laboratory study, frozen meniscus allograft samples were injected vertically with a cell suspension containing different ratios of MSCs and MCs or control (lactated ringers) and cultured for 28 days...
February 7, 2024: Cartilage
https://read.qxmd.com/read/38317317/effects-of-diclofenac-etalhyaluronate-si-613-ono-5704-on-cartilage-degeneration-in-arthritic-rats-and-inflammatory-cytokine-stimulated-human-chondrocytes
#15
JOURNAL ARTICLE
Shuhei Takada, Risa Nodera, Keiji Yoshioka
OBJECTIVE: Cartilage degeneration is a key feature of osteoarthritis (OA) and rheumatoid arthritis and is thought to negatively impact patients' quality of life. Diclofenac etalhyaluronate (DEH, SI-613/ONO-5704) is a hyaluronic acid (HA) derivative chemically bound to diclofenac (DF) that has been reported to improve OA symptoms; however, its effect on cartilage degeneration remains unknown. In the present study, we investigated the chondroprotective effect of DEH in rats with collagen-induced arthritis and interleukin-1β-stimulated human chondrocytes...
February 5, 2024: Cartilage
https://read.qxmd.com/read/38282570/subchondral-bone-alignment-in-osteochondral-allograft-transplants-for-large-oval-defects-of-the-medial-femoral-condyle-comparison-of-lateral-versus-medial-femoral-condyle-donors
#16
JOURNAL ARTICLE
Kelly M R Taylor, Conor S Locke, Timothy S Mologne, William D Bugbee, John A Grant
OBJECTIVE: Supply-demand mismatch of medial femoral condyle (MFC) osteochondral allografts (OCAs) remains a rate-limiting factor in the treatment of osteochondral defects of the femoral condyle. Surface contour mapping was used to determine whether a contralateral lateral femoral condyle (LFC) versus ipsilateral MFC OCA differs in the alignment of donor:native subchondral bone for large osteochondral defects of the MFC. DESIGN: Thirty fresh-frozen human femoral condyles were matched by tibial width into 10 groups of 3 condyles (MFC recipient, MFC donor, and LFC donor) each for 3 cartilage surgeons (90 condyles)...
January 29, 2024: Cartilage
https://read.qxmd.com/read/38279550/higher-age-is-associated-with-lower-likelihood-of-conversion-to-surgery-after-primary-nonoperative-treatment-for-osteochondral-lesions-of-the-talus
#17
JOURNAL ARTICLE
Tristan M F Buck, Jari Dahmen, J Nienke Altink, Quinten G H Rikken, Inger N Sierevelt, Sjoerd A S Stufkens, Gino M M J Kerkhoffs
INTRODUCTION: The first line of treatment for osteochondral lesions of the talus (OLT) is nonoperative. To date, there is limited evidence on risk factors that may influence conversion to surgery after primary nonoperative treatment for symptomatic OLTs. The aim of this study was therefore to identify risk factors for conversion to surgery after initial nonoperative treatment of OLTs. METHODS: For this cohort study, patients with a primary OLT who were nonoperatively treated for at least 6 months between 1990 and 2020 were included...
January 26, 2024: Cartilage
https://read.qxmd.com/read/38235738/clinical-outcomes-after-arthroscopic-treatment-of-extraspinal-diffuse-idiopathic-skeletal-hyperostosis-dish-involving-the-hip-joint
#18
JOURNAL ARTICLE
Fan Yang, Zhiyu Zhang, Hongjie Huang, Yan Xu, Jianquan Wang, Xiaodong Ju
OBJECTIVE: The hip joint can be affected by extraspinal diffuse idiopathic skeletal hyperostosis (DISH). This study aimed to compare the clinical characteristics of hips with DISH to those with mixed-type femoroacetabular impingement symptoms (FAIS). In addition, patient-reported outcome (PRO) scores were reported among patients with DISH involving the hip joint who underwent arthroscopic treatment. METHODS: A retrospective analysis was performed using data from patients who underwent hip arthroscopy between 2017 and 2021...
January 18, 2024: Cartilage
https://read.qxmd.com/read/38235711/management-and-amelioration-of-knee-joint-osteoarthritis-in-adults-using-a-novel-high-functional-bovine-collagen-peptide-as-a-nutritional-therapy-a-double-blind-prospective-multicentric-randomized-active-and-placebo-controlled-five-arm-clinical-study-to-evaluate
#19
JOURNAL ARTICLE
Sheena Devasia, Jinu T Joseph, Stephena P S, Seiko Koizumi, Liz Clarke, Sriraam V T, Abhilash Parameswaran Kailas, Shajil Madhavan
OBJECTIVE: The various functionalities of collagen peptides have generated a large interest in utilizing the bioactive peptides as a nutritional therapy to ameliorate various physiological degenerative conditions. Collagen peptides are observed to reduce the pain and aligned difficulties with respect to osteoarthritis. Here we report the enhanced ameliorating property of novel high-functional "Wellnex" Type J collagen peptides following a double-blind randomized active and placebo-controlled 5-arm clinical trial ( n = 100) by using it as a nutritional supplement in subjects with knee joint osteoarthritis in comparison with conventional bovine collagen peptides...
January 18, 2024: Cartilage
https://read.qxmd.com/read/38183234/the-actin-cytoskeleton-as-a-regulator-of-proteoglycan-4
#20
JOURNAL ARTICLE
Sofia Gonzalez-Nolde, Cameron J Schweiger, Elizabeth E R Davis, Thomas J Manzoni, Samer M I Hussein, Tannin A Schmidt, Stephanie G Cone, Gregory D Jay, Justin Parreno
OBJECTIVE: The superficial zone (SZ) of articular cartilage is responsible for distributing shear forces for optimal cartilage loading and contributes to joint lubrication through the production of proteoglycan 4 (PRG4). PRG4 plays a critical role in joint homeostasis and is chondroprotective. Normal PRG4 production is affected by inflammation and irregular mechanical loading in post-traumatic osteoarthritis (PTOA). THe SZ chondrocyte (SZC) phenotype, including PRG4 expression, is regulated by the actin cytoskeleton in vitro ...
January 6, 2024: Cartilage
journal
journal
42663
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.