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Cartilage

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https://www.readbyqxmd.com/read/29126367/t2-mapping-of-acetabular-cartilage-in-patients-with-femoroacetabular-impingement-at-3-tesla-comparative-analysis-with-arthroscopic-findings
#1
Tobias Hesper, Christina Neugroda, Christoph Schleich, Gerald Antoch, Harish Hosalkar, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To evaluate the diagnostic accuracy of T2*-mapping for detecting acetabular cartilage damage in patients with symptomatic femoroacetabular impingement (FAI). Design A total of 29 patients (17 females, 12 males, mean age 35.6 ± 12.8 years, mean body mass index 25.1 ± 4.1 kg/m(2), 16 right hips) with symptomatic FAI underwent T2* MRI and subsequent hip arthroscopy. T2* values were obtained by region of interest analysis in seven radially reformatted planes around the femoral neck (anterior, anterior-superior, superior-anterior, superior, superior-posterior, posterior-superior, posterior)...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29126349/bone-marrow-aspirate-concentrate-for-cartilage-defects-of-the-knee-from-bench-to-bedside-evidence
#2
Eric J Cotter, Kevin C Wang, Adam B Yanke, Susan Chubinskaya
Objective To critically evaluate the current basic science, translational, and clinical data regarding bone marrow aspirate concentrate (BMAC) in the setting of focal cartilage defects of the knee and describe clinical indications and future research questions surrounding the clinical utility of BMAC for treatment of these lesions. Design A literature search was performed using the PubMed and Ovid MEDLINE databases for studies in English (1980-2017) using keywords, including ["bone marrow aspirate" and "cartilage"], ["mesenchymal stem cells" and "cartilage"], and ["bone marrow aspirate" and "mesenchymal stem cells" and "orthopedics"]...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29096521/imaging-of-folate-receptor-expressing-macrophages-in-the-rat-groove-model-of-osteoarthritis-using-a-new-dota-folate-conjugate
#3
Huub M de Visser, Nicoline M Korthagen, Cristina Müller, Ruud M Ramakers, Gerard C Krijger, Floris P J G Lafeber, Freek J Beekman, Simon C Mastbergen, Harrie Weinans
Objective To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design In male Wistar rats, local cartilage damage was induced in addition to a standard ( n = 10) or high-fat diet ( n = 6). After 12 weeks, (111)In labeled folate conjugates were administered, and SPECT/CT (computed tomography) imaging was performed after 24 hours...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29047310/reserve-or-resident-progenitors-in-cartilage-comparative-analysis-of-chondrocytes-versus-chondroprogenitors-and-their-role-in-cartilage-repair
#4
Elizabeth Vinod, P R J V C Boopalan, Solomon Sathishkumar
Introduction Articular cartilage is made up of hyaline tissue embodying chondrocytes, which arise from mesenchymal stromal cells (MSCs) and specialized extracellular matrix. Despite possessing resident progenitors in and around the joint primed for chondrogenesis, cartilage has limited intrinsic capacity of repair and cell turnover. Advances in isolation, culture, and characterization of these progenitors have raised the possibility for their use in cell-based cartilage repair. Chondroprogenitors (CPCs) have been classified as MSCs and have been postulated to play a vital role in injury response and are identified by their colony forming ability, proliferative potential, telomere dynamics, multipotency, and expression of stem cell markers...
October 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28992763/hyperosmolar-potassium-k-treatment-suppresses-osteoarthritic-chondrocyte-catabolic-and-inflammatory-protein-production-in-a-3-dimensional-in-vitro-model
#5
Josh Erndt-Marino, Erik Trinkle, Mariah S Hahn
Objective The main goal of this study was to provide a proof-of-concept demonstrating that hyperosmolar K(+) solutions can limit production of catabolic and inflammatory mediators in human osteoarthritic chondrocytes (OACs). Methods A 3-dimensional in vitro model with poly(ethylene glycol) diacrylate (PEGDA) hydrogels was used. Catabolic and pro-inflammatory protein production from encapsulated OACs was assessed following culture for 1 or 7 days in the presence or absence of 80 mM K(+) gluconate, 80 mM sodium (Na(+)) gluconate, or 160 mM sucrose, each added to culture media (final osmolarity ~490 mOsm)...
October 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28980486/comparison-of-near-infrared-spectroscopy-with-needle-indentation-and-histology-for-the-determination-of-cartilage-thickness-in-the-large-animal-model-sheep
#6
Victoria Horbert, Matthias Lange, Thomas Reuter, Martin Hoffmann, Sabine Bischoff, Juliane Borowski, Harald Schubert, Dominik Driesch, Joerg Mika, Christof Hurschler, Raimund W Kinne
The suitability of near-infrared spectroscopy (NIRS) for non-destructive measurement of cartilage thickness was compared with the gold standard needle indentation. A combination of NIRS and biomechanical indentation (NIRS-B) was used to address the influence of varying loads routinely applied for hand-guided NIRS during real-life surgery on the accuracy of NIRS-based thickness prediction. NIRS-B was performed under three different loading conditions in 40 osteochondral cylinders from the load-bearing area of the medial and lateral femur condyle of 20 cadaver joints (left stifle joints; female Merino sheep; 6...
October 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28933195/biophysical-stimuli-a-review-of-electrical-and-mechanical-stimulation-in-hyaline-cartilage
#7
Juan J Vaca-González, Johana M Guevara, Miguel A Moncayo, Hector Castro-Abril, Yoshie Hata, Diego A Garzón-Alvarado
Objective Hyaline cartilage degenerative pathologies induce morphologic and biomechanical changes resulting in cartilage tissue damage. In pursuit of therapeutic options, electrical and mechanical stimulation have been proposed for improving tissue engineering approaches for cartilage repair. The purpose of this review was to highlight the effect of electrical stimulation and mechanical stimuli in chondrocyte behavior. Design Different information sources and the MEDLINE database were systematically revised to summarize the different contributions for the past 40 years...
September 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28934884/effect-of-a-rapidly-degrading-presolidified-10-kda-chitosan-blood-implant-and-subchondral-marrow-stimulation-surgical-approach-on-cartilage-resurfacing-in-a-sheep-model
#8
Angela D Bell, Mark B Hurtig, Eric Quenneville, Georges-Étienne Rivard, Caroline D Hoemann
Objective This study tested the hypothesis that presolidified chitosan-blood implants are retained in subchondral bone channels perforated in critical-size sheep cartilage defects, and promote bone repair and hyaline-like cartilage resurfacing versus blood implant. Design Cartilage defects (10 × 10 mm) with 3 bone channels (1 drill, 2 Jamshidi biopsy, 2 mm diameter), and 6 small microfracture holes were created bilaterally in n = 11 sheep knee medial condyles. In one knee, 10 kDa chitosan-NaCl/blood implant (presolidified using recombinant factor VIIa or tissue factor), was inserted into each drill and Jamshidi hole...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934883/contrast-enhanced-computed-tomography-enables-quantitative-evaluation-of-tissue-properties-at-intrajoint-regions-in-cadaveric-knee-cartilage
#9
Rachel C Stewart, Juuso T J Honkanen, Harri T Kokkonen, Virpi Tiitu, Simo Saarakkala, Antti Joukainen, Brian D Snyder, Jukka S Jurvelin, Mark W Grinstaff, Juha Töyräs
Objective The aim of this study was to investigate whether the concentration of the anionic contrast agent ioxaglate, as quantitated by contrast-enhanced computed tomography (CECT) using a clinical cone-beam CT (CBCT) instrument, reflects biochemical, histological, and biomechanical characteristics of articular cartilage imaged in an ex vivo, intact human knee joint. Design An osteoarthritic human cadaveric knee joint (91 years old) was injected with ioxaglate (36 mg I/mL) and imaged using CBCT over 61 hours of ioxaglate diffusion into cartilage...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934882/development-of-a-cartilage-shear-damage-model-to-investigate-the-impact-of-surface-injury-on-chondrocytes-and-extracellular-matrix-wear
#10
Robert L Trevino, Carol A Pacione, Anne-Marie Malfait, Susan Chubinskaya, Markus A Wimmer
Background Many i n vitro damage models investigate progression of cartilage degradation after a supraphysiologic, compressive impact at the surface and do not model shear-induced damage processes. Models also neglect the response to uninterrupted tribological stress after damage. It was hypothesized that shear-induced removal of the superficial zone would accelerate matrix degradation when damage was followed by continued load and articulation. Methods Bovine cartilage underwent a 5-day test. Shear-damaged samples experienced 2 days of damage induction with articulation against polyethylene and then continued articulation against cartilage (CoC), articulation against metal (MoC), or rest as free-swelling control (FSC)...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934881/effectiveness-of-lavage-techniques-in-removing-immunogenic-elements-from-osteochondral-allografts
#11
Maximilian A Meyer, Mark A McCarthy, Matthew E Gitelis, Sarah G Poland, Atsushi Urita, Susan Chubinskaya, Adam B Yanke, Brian J Cole
Objective This study aimed to compare standard saline lavage to combination saline and high-pressure carbon dioxide (CO2) lavage in removing marrow elements from osteochondral allografts. Design Six fresh hemicondyles were obtained. Three osteochondral allograft plugs (15-mm diameter, 6-mm depth) were harvested from each hemicondyle and randomized to 1 of 3 treatment arms: A, no lavage; B, 1 L standard saline lavage; C, simultaneous saline (1 L) and 1-minute high-pressure CO2 lavage. After hematoxylin and eosin staining, a "percentage fill" of remaining marrow elements was calculated for each overall sample and then repeated in 3 distinct compartments for each sample based on depth from surface: 1, deepest third; 2, middle third; and 3, most superficial third...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934880/three-dimensional-bioprinting-and-its-potential-in-the-field-of-articular-cartilage-regeneration
#12
Vivian H M Mouser, Riccardo Levato, Lawrence J Bonassar, Darryl D D'Lima, Daniel A Grande, Travis J Klein, Daniel B F Saris, Marcy Zenobi-Wong, Debby Gawlitta, Jos Malda
Three-dimensional (3D) bioprinting techniques can be used for the fabrication of personalized, regenerative constructs for tissue repair. The current article provides insight into the potential and opportunities of 3D bioprinting for the fabrication of cartilage regenerative constructs. Although 3D printing is already used in the orthopedic clinic, the shift toward 3D bioprinting has not yet occurred. We believe that this shift will provide an important step forward in the field of cartilage regeneration. Three-dimensional bioprinting techniques allow incorporation of cells and biological cues during the manufacturing process, to generate biologically active implants...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934879/two-year-evaluation-of-osteochondral-repair-with-a-novel-biphasic-graft-saturated-in-bone-marrow-in-an-equine-model
#13
Taralyn M McCarrel, Sarah L Pownder, Susannah Gilbert, Matthew F Koff, Emme Castiglione, Ryan A Saska, Gino Bradica, Lisa A Fortier
Objective To evaluate a biphasic cartilage repair device (CRD) for feasibility of arthroscopic implantation, safety, biocompatibility, and efficacy for long-term repair of large osteochondral defects. Methods The CRD was press-fit into defects (10 mm diameter, 10 mm deep) created in the femoral trochlea of 12 horses. In the contralateral limb, 10 mm diameter full-thickness chondral defects were treated with microfracture (MFX). Radiographs were obtained pre- and postoperatively, and at 4, 12, and 24 months...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#14
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934877/activin-and-nodal-are-not-suitable-alternatives-to-tgf%C3%AE-for-chondrogenic-differentiation-of-mesenchymal-stem-cells
#15
Laurie M G de Kroon, Esmeralda N Blaney Davidson, Roberto Narcisi, Eric Farrell, Peter M van der Kraan, Gerjo J V M van Osch
Objective Previously, we demonstrated the importance of transforming growth factor-β (TGFβ)-activated SMAD2/3 signaling in chondrogenesis of bone marrow-derived mesenchymal stem cells (BMSCs). However, TGFβ also signals via the SMAD1/5/9 pathway, which is known to induce terminal differentiation of BMSCs. In this study, we investigated whether other SMAD2/3-activating ligands, Activin and Nodal, can induce chondrogenic differentiation of BMSCs without inducing terminal differentiation. Design Activation of SMAD2/3 signaling and chondrogenesis were evaluated in human BMSCs ( N = 3 donors) stimulated with TGFβ, Activin, or Nodal...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934876/comparison-of-intra-articular-injection-of-hyaluronic-acid-and-n-acetyl-cysteine-in-the-treatment-of-knee-osteoarthritis-a-pilot-study
#16
Mustafa Ozcamdalli, Abdulhamit Misir, Turan Bilge Kizkapan, Erdal Uzun, Fuat Duygulu, Cevat Yazici, Ibrahim Halil Kafadar
Objective To compare the relative effectiveness of intra-articular N-acetyl cysteine (NAC) and hyaluronic acid (HA) on pain, function and cartilage degradation markers in patients with mild to moderate knee osteoarthritis (OA). Design We prospectively conducted a clinical trial with 20 patients having a diagnosis of Kellgren-Lawrence grade 2-3 knee OA, and randomly allocated to the HA or NAC groups. Groups were matched on age, sex, and body mass index. Injections of 3-mL HA (Hylan G-F 20) or 3-mL NAC (Asist ampoule) were administered as a single shot...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28934875/natural-type-ii-collagen-hydrogel-fibrin-sealant-and-adipose-derived-stem-cells-as-a-promising-combination-for-articular-cartilage-repair
#17
Mariana Lazarini, Pedro Bordeaux-Rego, Renata Giardini-Rosa, Adriana S S Duarte, Mariana Ozello Baratti, Alessandro Rozim Zorzi, João Batista de Miranda, Carlos Lenz Cesar, Ângela Luzo, Sara Teresinha Olalla Saad
Objective Articular cartilage is an avascular tissue with limited ability of self-regeneration and the current clinical treatments have restricted capacity to restore damages induced by trauma or diseases. Therefore, new techniques are being tested for cartilage repair, using scaffolds and/or stem cells. Although type II collagen hydrogel, fibrin sealant, and adipose-derived stem cells (ASCs) represent suitable alternatives for cartilage formation, their combination has not yet been investigated in vivo for focal articular cartilage defects...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28604062/cartilage-regeneration-in-full-thickness-patellar-chondral-defects-treated-with-particulated-juvenile-articular-allograft-cartilage-an-mri-analysis
#18
Brian Grawe, Alissa Burge, Joseph Nguyen, Sabrina Strickland, Russell Warren, Scott Rodeo, Beth Shubin Stein
Background Full-thickness cartilage lesions of the patella represent a common source of pain and dysfunction. Previously reported surgical treatment options include marrow stimulation, cell-based treatments, and osteochondral transfer. Minced juvenile allograft cartilage is a novel treatment option that allows for a single stage approach for these lesions. Hypothesis Particulated juvenile allograft cartilage (PJAC) for the treatment of chondral defects of the patella would offer acceptable lesion fill rates, mature over time, and not be associated with any negative biologic effects on the surrounding tissue...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28466650/t2-mapping-for-hip-joint-cartilage-assessment-pre-mri-exercise-and-time-of-imaging-do-not-bias-the-t2-measurement-in-asymptomatic-volunteers
#19
Tobias Hesper, Harish S Hosalkar, Christoph Schleich, Gerald Antoch, Götz H Welsch, Rüdiger Krauspe, Christoph Zilkens, Bernd Bittersohl
Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo steady state (DESS) sequence for morphological cartilage assessment and a multi-echo data image combination sequence for the T2* measurement. T2* values were obtained between 8 and 11 a.m., between 3 and 6 p...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease-a-systematic-review-of-clinical-studies
#20
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
October 2017: Cartilage
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