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Journal of Clinical and Aesthetic Dermatology

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https://www.readbyqxmd.com/read/27847550/a-split-face-evaluation-to-assess-the-efficacy-of-a-hydrolyzed-roe-cream-in-the-reduction-of-erythema-following-chemical-peel
#1
Vic A Narurkar
Objective:To evaluate a hydrolyzed roe cream in the reduction of facial erythema following a chemical peel treatment. Edema was also assessed. Design:The facial cream was applied to one side of the face of 30 healthy female subjects (average age = 54.9 years, range 33-65 years) immediately following 4 to 15 minutes peel treatment. The opposite side remained untreated. Visia-CR digital photographs were taken at baseline and 8 and 24 hours post facial peel. Objective dermal irritation assessments were done by a blinded investigator, graded on severity of facial erythema and edema on a 5-point scoring scale; 0=none, 1 =slight,2=mild, 3=moderate, 4=severe...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27847549/results-of-a-multicenter-randomized-controlled-trial-of-a-hydrogen-peroxide-based-kit-versus-a-benzoyl-peroxide-based-kit-in-mild-to-moderate-acne
#2
Stefano Veraldi, Giuseppe Micali, Enzo Berardesca, Federica Dall'Oglio, Jo Linda Sinagra, Elena Guanziroli
Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mild-to-moderate acne. Methods: In this eight-week multicenter study, patients were randomized to either a hydrogen peroxide-based or a benzoyl peroxide-based regimen.The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27847548/needlestick-and-sharps-injuries-in-dermatologic-surgery-a-review-of-preventative-techniques-and-post-exposure-protocols
#3
REVIEW
Christopher Rizk, Holly Monroe, Ida Orengo, Theodore Rosen
Background: Needlestickand sharps injuries are the leading causes of morbidity in the dermatologicfield. Among medical specialties, surgeons and dermatologists have the highest rates of needlestickand sharps injuries.The high rates of needlestickand sharps injuries in dermatology not only apply to physicians, but also to nurses, physician assistants, and technicians in the demnatologic field. Needlestickand sharps injuries are of great concern due to the monetary, opportunity, social, and emotional costs associated with their occurrence...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27847547/systemic-therapies-for-late-stage-melanoma
#4
REVIEW
Peter W Hashim, Philip Friedlander, Gary Goldenberg
Late-stage melanoma is associated with high morbidity and mortality. Classic treatment methods relied on cytotoxic chemotherapy, which is limited by low response rates and significant adverse effects. Recent advances in immunogenetics have led to the advent of important new systemictreatments.Thisarticle reviews the latest therapy options for advanced melanoma.
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27847546/topical-silicone-sheet-application-in-the-treatment-of-hypertrophic-scars-and-keloids
#5
Iris Westra, Frank B Niessen
Objective: Since the early 1980s, topical silicone sheets have been used in the treatment of hypertrophic scars and keloids.This study aimed to determine the optimal duration and application of these sheets. Design: multi-centered therapeutic study. Setting and participants: A total of 224 patients were included in this study; 205 patients with hypertrophic scars and 19 patients with keloids. Patients received treatment with a topical silicone sheet. Treated scars varied in age, ranging from two weeks to 62 years and treatment time ranged from one month to 16 months...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27847545/efficacy-safety-and-dermal-tolerability-of-dapsone-gel-7-5-in-patients-with-moderate-acne-vulgaris-a-pooled-analysis-of-two-phase-3-trials
#6
Diane M Thiboutot, Leon Kircik, Amy McMichael, Fran E Cook-Bolden, Stephen K Tyring, David R Berk, Joan-En Chang-Lin, Vince Lin, Alexandre Kaoukhov
Objective: Assess efficacy and safety of once-daily topical dapsone gel, 7.5% compared with vehicle for treating acne vulgaris (acne). Design: A pooled analysis of data from two identically designed, randomized, double-blind, vehicle-controlled, multicenter, 12-week clinical trials. Setting: Study sites in the United States and Canada. Participants: overall, 4,340 patients were randomized 1:1 to dapsone and vehicle. Criteria included age 12 years or older with acne diagnosis, 20 to 50 facial inflammatory lesions (papules and pustules), 30 to 100 facial noninflammatory lesions (open and closed comedones), and acne grade of 3 (moderate) on the Global Acne Assessment Score scale...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878063/retrospective-study-of-punch-scoring-versus-freehand-approach-for-first-stage-mohs-micrographic-surgery
#7
Nikoo Cheraghi, Abdulhadi Jfri, Robert Bacigalupi, Hooman Khorasani
Objective: The objective was to observe whether there is a difference in the number of subjects requiring more than one stage of Mohs micrographic surgery for small lesion nonmelanoma skin cancers using the punch scoring method versus freehand approach. Design: Retrospective review. Setting: Outpatient Mohs Clinic. Participants: Thirty patients with small lesion (<5mm) basal cell and squamous cell carcinoma who had Mohs micrographic surgery using either the punch scoring method (15) for scoring the first layer or the freehand method (15)...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878062/pediatric-lichen-sclerosus-a-review-of-the-literature-and-management-recommendations
#8
REVIEW
Huyenlan Dinh, Stephen M Purcell, Catherine Chung, Andrea L Zaenglein
Lichen sclerosus is an uncommon, inflammatory disease of the skin and mucosa that can cause significant pruritus, pain, and scarring. There are two peaks of incidence: one in adult females, and the other in young girls. Early recognition and prompt management of the disorder is crucial in preventing long-lasting complications. This article reviews lichen sclerosus in children and provides evidence-based guidance for treatment in the pediatric population.
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878061/oral-apremilast-for-the-treatment-of-plaque-psoriasis
#9
REVIEW
James Q Del Rosso, Leon Kircik
This article provides an update on the use of oral apremilast, a phosphodiesterase-4 (PDE4) inhibitor, for the treatment of plaque psoriasis. Emphasis is placed on safety evaluations, although efficacy considerations are also addressed. Both two-year and three -year data analyses support the favorable safety profile reported in pivotal trials with this agent. Although effective in many study subjects despite baseline characteristics, higher response rates were noted in those with a baseline psoriasis area and severity index (PASI) score <20 and in subjects not previously treated with systemic therapy for psoriasis...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878060/a-retrospective-analysis-comparing-the-new-standardized-letter-of-recommendation-in-dermatology-with-the-classic-narrative-letter-of-recommendation
#10
Jessica A Kaffenberger, Joy Mosser, Grace Lee, Llana Pootrakul, Katya Harfmann, Stephanie Fabbro, Esteban Fernandez Faith, David Carr, Alisha Plotner, Matthew Zirwas, Benjamin H Kaffenberger
Background: In an effort to avoid numerous problems associated with narrative letters of recommendation, a dermatology standardized letter of recommendation was utilized in the 2014-2015 resident application cycle. Objective: A comparison of the standardized letter of recommendation and narrative letters of recommendation from a single institution and application cycle to determine if the standardized letter of recommendation met its original goals of efficiency, applicant stratification, and validity. Methods: Eight dermatologists assessed all standardized letters of recommendation/narrative letters of recommendation pairs received during the 2014-2015 application cycle...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878059/assessment-of-online-patient-education-materials-from-major-dermatologic-associations
#11
Ann M John, Elizabeth S John, David R Hansberry, William Clark Lambert
Objective: Patients increasingly use the internet to find medical information regarding their conditions and treatments. Physicians often supplement visits with written education materials. Online patient education materials from major dermatologic associations should be written at appropriate reading levels to optimize utility for patients. The purpose of this study is to assess online patient education materials from major dermatologic associations and determine if they are written at the fourth to sixth grade level recommended by the American Medical Association and National Institutes of Health...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27878058/patient-factors-and-their-association-with-nonmelanoma-skin-cancer-morbidity-and-the-performance-of-self-skin-exams-a-cross-sectional-study
#12
Kyle T Amber, Romi Bloom, Mohammad-Ali Yazdani Abyaneh, Leyre A Falto-Aizpurua, Martha Viera, Martin N Zaiac, Keyvan Nouri, Shasa Hu
Objective: Mohs micrographic surgery is widely utilized for the treatment of nonmelanoma skin cancers with the advantage of tissue sparing and higher cure rate. The preoperative tumor size and post-Mohs micrographic surgery defect size are useful surrogate measures of nonmelanoma skin cancer morbidity. The authors sought to evaluate whether gender, Hispanic ethnicity, socioeconomic status, sun-safe practices and self-skin exams affected tumor size and Mohs micrographic surgery defect size. They also investigated factors associated with self-skin exams...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27853485/study-on-the-efficacy-of-platelet-rich-fibrin-matrix-in-hair-follicular-unit-transplantation-in-androgenetic-alopecia-patients
#13
Sandeep Mahapatra, Dhruva Kumar, Vignesh Subramanian, Swarup K Chakrabarti, Kaushik D Deb
Objective: Hair loss is a significant problem worldwide. The most common cause of hair loss in men is male androgenetic alopecia, male pattern baldness, which is primarily due to the presence of nonfunctional or dead hair follicles in the scalp. Hair follicular unit transplantation has been a widely used technique to transplant hair follicles into bald areas. Although follicular unit transplantation generally gives satisfactory hair transplantation, efforts have been made to further increase the efficacy of follicular unit transplantation in hair regeneration...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27800119/updates-on-psoriasis-and-cutaneous-oncology-proceedings-from-the-2016-mauiderm-meeting-based-on-presentations-by
#14
George Martin, Bruce E Strober, Craig L Leonardi, Joel M Gelfand, Andrew Blauvelt, Arthur Kavanaugh, Linda Stein Gold, Brian Berman, Ted Rosen, Eggert Stockfleth
No abstract text is available yet for this article.
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672419/central-forehead-reconstruction-with-a-simple-primary-vertical-linear-closure
#15
Ani Tajirian, Michelle Tsui
OBJECTIVE: Following Mohs surgery, medium-to-large defects on the central forehead can often be complicated to surgically reconstruct. In this paper, the authors discuss possible central forehead reconstructions and report their successful experience employing a simple primary vertical linear closure with a special technique to demarcate forehead rhytides rather than performing an overly complicated flap or graft. CASE REPORT: The patient was a 57-year-old man who presented with a broad superficial basal cell carcinoma that required treatment with Mohs surgery...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672418/fully-regressive-melanoma-a-case-without-metastasis
#16
Eric Ehrsam, Joseph R Kallini, Damien Lebas, Amor Khachemoune, Philippe Modiano, Hervé Cotten
Fully regressive melanoma is a phenomenon in which the primary cutaneous melanoma becomes completely replaced by fibrotic components as a result of host immune response. Although 10 to 35 percent of cases of cutaneous melanomas may partially regress, fully regressive melanoma is very rare; only 47 cases have been reported in the literature to date. AH of the cases of fully regressive melanoma reported in the literature were diagnosed in conjunction with metastasis on a patient. The authors describe a case of fully regressive melanoma without any metastases at the time of its diagnosis...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672417/the-use-of-noninvasive-optical-coherence-tomography-to-monitor-the-treatment-progress-of-vismodegib-and-imiquimod-5-cream-in-a-transplant-patient-with-advanced-basal-cell-carcinoma-of-the-nose
#17
Orit Markowitz, Michelle Schwartz
Immunosuppressed transplant recipients have increased risk for the development of basal cell carcinoma skin cancers. While oral vismodegib therapy has been successful in treating locally advanced basal cell tumors, few studies document its use and efficacy in organ transplant patients. In this immunocompromised population, topical imiquimod 5% cream has been shown to be an effective and well-tolerated option for superficial and nodular basal cell carcinomas. To the authors' knowledge, no data documents the use of optical coherence tomography, a noninvasive imaging technique, to monitor progress of such combined therapies on in vivo skin...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672416/application-of-nail-polish-during-topical-management-of-onychomycosis-are-data-available-to-guide-the-clinician-about-what-to-tell-their-patients
#18
REVIEW
James Q Del Rosso
Topical antifungal management of toenail onychomycosis has been fraught with several therapeutic challenges including difficulty gaining access to the site of infection and the need for prolonged durations of therapy. In addition, there has been a marked lack of information on the impact of toenail polish application on drug penetration after application. This article reviews available data from studies evaluating the effect of nail polish on antifungal drag penetration using ex vivo laboratory models with cadaver fingernail plates with both tavaborole 5% solution and efinaconazole 10% solution...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672415/new-oral-therapies-for-psoriasis-a-comprehensive-review
#19
REVIEW
Gary Goldenberg, Julien Lanoue, Joanna Dong
Conventional oral therapies for psoriasis, including methotrexate, cyclosporine, and acitretin, have generally unfavorable safety profiles and are not ideal for long-standing use. Thus, new oral therapies are necessary for patients with more moderate disease, patients who prefer oral treatments to injectable biologies, and patients who failed conventional therapies. The authors review here the clinical and safety evidence of phosphodiesterase 4 inhibitor, apremilast, janus kinase inhibitors, including tofacitinib, and fumarie acid esters as additional options in oral psoriasis therapy...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27672414/gender-differences-in-self-assessed-health-related-quality-of-life-in-children-with-atopic-dermatitis
#20
Pavel V Chernyshov, Roger C Ho, Fiorella Monti, Anna Jirakova, Svitlana S Velitchko, Jana Hercogova, Erica Neri
BACKGROUND: Atopic dermatitis has a significant impact on quality of life of children and families. OBJECTIVE: It is important to assess gender differences in health-related quality of life in children with atopic dermatitis in order to effectively use health-related quality of life results. METHODS: Children 5- to 16-years of age with atopic dermatitis from Italy, Singapore, Czech Republic, and Ukraine were divided into two groups (boys and girls)...
August 2016: Journal of Clinical and Aesthetic Dermatology
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