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Arthritis Care & Research

Pavandeep Mehat, Mohammad Atiquzzaman, John M Esdaile, Antonio Avina-Zubieta, Mary A De Vera
OBJECTIVE: Medication non-adherence has not been well characterized in systemic lupus erythematosus (SLE). Our objective was to a conduct a systematic review of the literature examining the burden and determinants of medication non-adherence in SLE. METHODS: We conducted a systematic search of MEDLINE (1946-2015), EMBASE (1974-2015), and WEB OF SCIENCE (1900-2015) databases and selected original studies of SLE patients that evaluated non-adherence to SLE therapies as the primary study outcome...
January 13, 2017: Arthritis Care & Research
Barbara Gandek, John E Ware
OBJECTIVE: To evaluate validity and responsiveness of the Knee injury and Osteoarthritis Outcome Score (KOOS) in relation to other patient-reported outcome measures before and after total knee replacement (TKR). METHODS: Pre-TKR and 6-month post-TKR data from 1,143 patients in a U.S. joint replacement cohort was used to compare the KOOS, WOMAC and SF-36 Health Survey. Validity was evaluated with multiple methods, including correlations of pre-TKR scale scores and ANOVA models that used pre-TKR data to compare the relative validity (RV) of scales in discriminating between groups differing in assistive walking device use and number of comorbid conditions and used post-TKR minus pre-TKR change scores to assess RV of scales in discriminating between groups rating themselves as better, same or worse (BSW) in their capability to do activities at 6 months...
January 13, 2017: Arthritis Care & Research
Camilla Bengtsson, Susan Malspeis, Cecilia Orellana, Jeffrey A Sparks, Karen H Costenbader, Elizabeth W Karlson
OBJECTIVE: To investigate whether menopausal factors are associated with development of serologic rheumatoid arthritis (RA) phenotypes. METHODS: Data were analyzed from Nurses' Health Studies (NHS, 1976-2010; NHSII 1989-2011). In NHS 120,700 female nurses aged 30-55 and in NHSII 116,430 female nurses aged 25-42 were followed via biennial questionnaires on lifestyle and disease outcomes. In total, 1,096 incident RA cases were confirmed by questionnaire and chart review...
January 13, 2017: Arthritis Care & Research
Sarah Nelson, Natoshia Cunningham, James Peugh, Anjana Jagpal, Leslie M Arnold, Anne Lynch-Jordan, Susmita Kashikar-Zuck
OBJECTIVE: The primary objectives of this study were to examine the differential presentation(s) in young adults with Juvenile-onset Fibromyalgia (JFM) with and without a history of trauma as compared to healthy controls across psychological and health-related outcomes. METHODS: 110 participants (86 with JFM and 24 healthy controls; Mage =23.4 years) completed a structured clinical interview to assess for trauma and psychological comorbidities and self-report questionnaires on pain, physical functioning, and healthcare utilization...
January 13, 2017: Arthritis Care & Research
Jemima Albayda, Iago Pinal-Fernandez, Wilson Huang, Cassie Parks, Julie Paik, Livia Casciola-Rosen, Sonye K Danoff, Cheilonda Johnson, Lisa Christopher-Stine, Andrew L Mammen
OBJECTIVES: Dermatomyositis (DM) patients typically present with proximal weakness and autoantibodies that are associated with distinct clinical phenotypes. We observed that DM patients with autoantibodies recognizing the nuclear matrix protein NXP-2 often presented with especially severe weakness. The aim of this study was to characterize clinical features associated with anti-NXP-2 autoantibodies. METHODS: 235 DM patients underwent testing for anti-NXP-2 autoantibodies...
January 13, 2017: Arthritis Care & Research
Daniel L Riddle, Robert A Perera
No abstract text is available yet for this article.
January 13, 2017: Arthritis Care & Research
Zhaoli Dai, David Felson, Yuqing Zhang
No abstract text is available yet for this article.
January 13, 2017: Arthritis Care & Research
Ali Ibrahim, Dafna D Gladman, Arane Thavaneswaran, Lihi Eder, Philip Helliwell, Richard J Cook, Vinod Chandran
OBJECTIVES: There is no widely recognized method to assess axial disease in psoriatic arthritis (PsA). We aimed to determine the sensitivity to change of the Bath Ankylosing Spondylitis (AS) Radiology Index- spine (BASRI-spine), the modified Stoke AS spinal score (mSASSS), the Radiographic AS spinal score (RASSS) and the PsA Spondylitis Radiology Index (PASRI) in Axial PsA (AxPsA). METHODS: Radiographs of 105 patients with AxPsA were retrieved for 2 time points at least 2 years apart and subsequently anonymized...
January 13, 2017: Arthritis Care & Research
Patricia Katz, Sofia Pedro, Kaleb Michaud
BACKGROUND: The Patient-Reported Outcomes Measurement Information System (PROMIS®) was developed to improve measurement of patient-reported outcomes. We examined performance of the PROMIS-29 Profile (P29) in persons with rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia (FM), and systemic lupus erythematosus (SLE). METHODS: Participants in the National Data Bank for Rheumatic Diseases completed the P29, which includes 4-item forms for seven PROMIS domains...
December 28, 2016: Arthritis Care & Research
Yannick Palmowski, Thomas Buttgereit, Christian Dejaco, Johannes W Bijlsma, Eric L Matteson, Marieke Voshaar, Maarten Boers, Frank Buttgereit
OBJECTIVE: To describe the perception on the current role of systemic glucocorticoids (GC) in the management of rheumatoid arthritis (RA) by examining their importance and the current level of evidence in recent guidelines, and to identify open questions to be addressed in future guidelines and research projects. METHODS: Systematic literature review using the databases PubMed, EMBASE and Cochrane for guidelines on the pharmacological treatment of RA. Retrieved articles were evaluated regarding their quality using the AGREE II tool and scrutinized for all relevant information concerning the use of GC...
December 28, 2016: Arthritis Care & Research
Dorothy D Dunlop, Jing Song, Jungwha Lee, Abigail L Gilbert, Pamela A Semanik, Linda Ehrlich-Jones, Christine A Pellegrini, Daniel Pinto, Barbara Ainsworth, Rowland W Chang
OBJECTIVES: The objective is to identify an evidence-based minimum physical activity threshold to predict improved or sustained high function for adults with lower limb joint symptoms. METHODS: Prospective multi-site data from 1629 adults aged 49 years or older with symptomatic lower limb joint pain/aching/stiffness participating in Osteoarthritis Initiative accelerometer monitoring substudy were clinically assessed two years apart. Improved/high function in 2-year gait speed and patient-reported outcomes (PRO) were based on improving or remaining in the best (i...
December 28, 2016: Arthritis Care & Research
Tina D Mahajan, James R O'Dell
No abstract text is available yet for this article.
December 28, 2016: Arthritis Care & Research
Jessica Widdifield, Noah M Ivers, Sasha Bernatsky, R Liisa Jaakkimainen, Claire Bombardier, J Carter Thorne, Vandana Ahluwalia, J Michael Paterson, Jacqueline Young, Laura Wing, Karen Tu
OBJECTIVE: Quality measurement for rheumatoid arthritis (RA) patients has largely focused on care provided by rheumatologists. Our aim was to develop and assess quality measures related to the screening and management of comorbidity in RA patients in primary care. METHODS: We used the primary care Electronic Medical Record Administrative data Linked Database in Ontario, Canada. We harmonized Canadian general population and RA clinical recommendations to develop and assess screening, process, and outcome measures...
December 20, 2016: Arthritis Care & Research
Marie Falahee, Gwenda Simons, Christopher D Buckley, Mats Hansson, Rebecca J Stack, Karim Raza
OBJECTIVES: To understand the perspectives of patients with rheumatoid arthritis (RA) about the risk of their relatives developing RA in the future, and about communicating with their relatives about risk and its modulation. METHODS: Twenty-one RA patients took part in semi-structured interviews. RESULTS: Participants reported willingness to communicate with relatives about their risk of developing RA, but described choosing which relatives to communicate with, on the basis of their perceived receptivity to such risk information...
December 20, 2016: Arthritis Care & Research
Ian M Ward, Eugene Kissin, Gurjit Kaeley, Joshua N Scott, Michelle Newkirk, Bernard A Hildebrand, Josh Lospinoso, Minna J Kohler, Jay B Higgs
OBJECTIVES: Limited literature exists on the sonographic appearance of the posterior tibialis (PTT) and the peroneus brevis (PBT) tendon entheses. We determined the anatomic features and best imaging techniques of normal PTT and PBT using musculoskeletal ultrasound and compared these findings to subjects with inflammatory arthritis. METHODS: Adult subjects were enrolled as: healthy controls (HC), rheumatoid arthritis (RA), and spondyloarthropathy (SpA). Bilateral PTT and PBT entheses were imaged longitudinally, comparing two angles of insonation: perpendicular to the skin surface and 45˚ cephalad...
December 20, 2016: Arthritis Care & Research
Laura C Cappelli, Anna Kristina Gutierrez, Clifton O Bingham, Ami A Shah
BACKGROUND: Immune checkpoint inhibitors (ICI) are improving prognosis in advanced stage cancers, but also lead to immune-related adverse events (IRAE). IRAEs targeting many organ systems have been reported, but musculoskeletal and rheumatic IRAE have not been well characterized. We systematically reviewed published literature on musculoskeletal and rheumatic IRAE to better understand prevalence and clinical characteristics. METHODS: Medline and CENTRAL databases were searched for articles reporting rheumatic and musculoskeletal IRAEs secondary to ICI treatment...
December 20, 2016: Arthritis Care & Research
Gemma Wallace, Suzie Cro, Caroline Doré, Leonard King, Stefan Kluzek, Andrew Price, Frank Roemer, Ali Guermazi, Richard Keen, Nigel Arden
Objective Painful knee osteoarthritis (KOA) has been associated with joint inflammation. There is however little literature correlating signs of localised inflammation with Contrast-enhanced (CE) Magnetic resonance imaging (MRI) of synovium. This study examined the relationship between clinical and functional markers of localised knee inflammation and CE MRI based synovial scores. Methods Patients with symptomatic KOA were enrolled into the randomised, double-blind, Vitamin D Evaluation in Osteoarthritis (VIDEO) trial...
December 20, 2016: Arthritis Care & Research
Maik Sliepen, Mirko Brandes, Dieter Rosenbaum
OBJECTIVE: To provide an up-to-date overview of physical activity monitors that are being/have been used within hip and knee osteoarthritis research. METHODS: A review was conducted to identify activity monitors used in hip and knee osteoarthritis research. In order to identify the relevant literature to-date, the MEDLINE (via Pubmed), EMBASE (via OVID) and SCOPUS databases were searched from January 2000 until January 2016. Per activity monitor, a broad range of specifications was identified by extracting information from the manufacturers' websites, device manuals and literature...
December 20, 2016: Arthritis Care & Research
Déborah Puyraimond-Zemmour, Adrien Etcheto, Bruno Fautrel, Andra Balanescu, Maarten de Wit, Turid Heiberg, Kati Otsa, Tore K Kvien, Maxime Dougados, Laure Gossec
INTRODUCTION: The objective was to explore the link between a patient acceptable symptom state (PASS) and patient-perceived impact in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). PATIENTS AND METHODS: Cross-sectional study of unselected patients with definite RA or PsA. Pain, functional capacity, fatigue, coping and sleep disturbance were assessed by a numeric rating scale (0-10) and compared between patients in PASS or not (Cohen's effect sizes). The domains of health associated with PASS status were assessed by multivariate forward logistic regression, and PASS thresholds were determined using the 75(th) percentile method and ROC analyses...
December 20, 2016: Arthritis Care & Research
Helga Radner, Tamara Lesperance, Neil A Accortt, Daniel H Solomon
OBJECTIVE: To estimate prevalence and incidence of cardiovascular (CV) risk factors of hypertension, diabetes mellitus, hyperlipidemia, and obesity in patients with rheumatoid arthritis (RA), psoriasis (PsO), or psoriatic arthritis (PsA). METHODS: Patients with RA, PsO, or PsA were identified based on medical and pharmacy claims from the MarketScan claims databases from January 1, 2002 through December 31, 2014. Primary outcomes included age- and sex-standardized prevalence of CV risk factors during the 12 months preceding diagnosis date and incidence rates per 1,000 patient-years with 95% confidence intervals (CI) during follow-up...
December 20, 2016: Arthritis Care & Research
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