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Arthritis Care & Research

Gui Tran, Paul Cowling, Toby Smith, Julie Bury, Adam Lucas, Andrew Barr, Sarah R Kingsbury, Philip G Conaghan
OBJECTIVE: Shoulder symptoms are common and imaging is being increasingly used to help with management. However, the relationship between imaging and symptoms remain unclear. This review aims to understand the relationship between imaging-detected pathologies, symptoms and their persistence. METHODS: A systematic review using Medline, EMBASE, Cochrane and grey literature was conducted to April 2017. The cross-sectional and longitudinal relationships between imaging-detected abnormalities and symptoms were analysed and associations qualitatively characterised by a best evidence synthesis based on study design, covariate adjustment and the Grade of Recommendations Assessment, Development and Evaluation (GRADE)...
March 7, 2018: Arthritis Care & Research
Jessica Widdifield, J Michael Paterson, Anjie Huang, Sasha Bernatsky
OBJECTIVE: To compare mortality rates, underlying causes of death, excess mortality and years of potential life lost (YPLL) among rheumatoid arthritis (RA) patients relative to the general population. METHODS: We studied an inception cohort of 87,114 Ontario RA patients and 348,456 age/sex/area-matched general population comparators over 2000 to 2013. All-cause, cause-specific, and excess mortality rates, mortality rate ratios (MRRs), and YPLL were estimated. RESULTS: A total of 11,778 (14% of) RA patients and 32,472 (9% of) comparators died during 508,385 and 1,769,365 person-years (PY) of follow-up, respectively, for corresponding mortality rates of 232 (95% CI 228, 236) and 184 (95% CI 182, 186) per 10,000 PYs...
March 7, 2018: Arthritis Care & Research
Ayako Nishino, Shin-Ya Kawashiri, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Tamami Yoshitama, Nobutaka Eiraku, Naoki Matsuoka, Akitomo Okada, Keita Fujikawa, Hiroaki Hamada, Tomomi Tsuru, Shuji Nagano, Yojiro Arinobu, Toshihiko Hidaka, Atsushi Kawakami
OBJECTIVE: To explore the variables associated with initial favorable power Doppler (PD) ultrasound (US) response induced by biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients with rheumatoid arthritis (RA). METHODS: We have been prospectively investigating the course of active RA patients using US after the introduction of b/tsDMARDs in the Kyushu region of Japan since June 2013. One hundred fifty patients have completed the first 6 months of observation at present and have been evaluated...
February 26, 2018: Arthritis Care & Research
Daniel Albert
According to the Arthritis Foundation there are more than 300,000 children in the US with juvenile arthritis and there are many more children with musculoskeletal conditions that could benefit from rheumatologic care. Yet there are only about 350 board certified pediatric rheumatologists in this country and 8 states do not have a single board certified practitioner. As a consequence over 75% of children with rheumatic disease are cared for by an adult certified rheumatologist. This article is protected by copyright...
February 26, 2018: Arthritis Care & Research
April Barnado, Robert J Carroll, Carolyn Casey, Lee Wheless, Joshua C Denny, Leslie J Crofford
OBJECTIVE: Phenome-wide association studies (PheWAS) scan across billing codes in the electronic health record (EHR) and re-purpose clinical EHR data for research. We examined if PheWAS could function as an EHR discovery tool for SLE and uncover novel clinical associations in male versus female SLE patients. METHODS: We used a de-identified version of the Vanderbilt University Medical Center EHR with over 2.8 million subjects. We performed PheWAS comparing 1) SLE cases vs...
February 26, 2018: Arthritis Care & Research
Joshua F Baker, Sogol Mostoufi-Moab, Jin Long, Babette Zemel, Said Ibrahim, Elena Taratuta, Mary B Leonard
PURPOSE: Rheumatoid arthritis (RA) is associated with adverse body composition profiles, and low muscle density due to accumulation of intramuscular fat. This study assessed associations between muscle density, body composition, muscle strength, and physical functioning in patients with RA and a reference group. METHODS: Patients with RA, ages 18-70 years, and healthy control participants completed whole-body DXA and peripheral quantitative CT (pQCT) to quantify appendicular lean mass (ALMI, kg/m2 ) and fat mass indices (FMI, kg/m2 ), visceral fat area, and muscle density...
February 26, 2018: Arthritis Care & Research
Louise M Thoma, Dorothy Dunlop, Jing Song, Jungwha Lee, Catrine Tudor-Locke, Elroy J Aguiar, Hiral Master, Meredith B Christiansen, Daniel K White
OBJECTIVE: To compare objectively-measured physical activity (PA) in older adults with symptomatic knee osteoarthritis (SxOA) with similarly aged adults without osteoarthritis (OA) or knee symptoms from the general population. METHODS: We included people age 50-85 years with SxOA from the Osteoarthritis Initiative (OAI, n=491), and people age 50-85 years from the general population from the National Health and Nutrition Examination Survey (NHANES, n=449). A uniaxial accelerometer was worn for >10 hours/day for >4 days in the NHANES in 2003-2004 (Actigraph 7124) and in the OAI in 2008-2010 (Actigraph GT1M)...
February 22, 2018: Arthritis Care & Research
Zachary S Wallace, Arezou Khosroshahi, Mollie D Carruthers, Cory A Perugino, Hyon Choi, Corrado Campochiaro, Emma L Culver, Frank Cortazar, Emanuel Della-Torre, Mikael Ebbo, Ana Fernandes, Luca Frulloni, Philip Hart, Omer Karadag, Shigeyuki Kawa, Mitsuhiro Kawano, Myung-Hwan Kim, Marco Lanzillotta, Shoko Matsui, Kazuichi Okazaki, Jay H Ryu, Takako Saeki, Nicolas Schleinitz, Paula Tanasa, Hisanori Umehara, George Webster, Wen Zhang, John H Stone
OBJECTIVE: IgG4-related disease (IgG4-RD) can cause fibro-inflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4-RD Responder Index (RI) was developed to help investigators assess the efficacy of treatment in a structured manner. We sought to validate the RI in a multi-national investigation. METHODS: The RI guides investigators through assessments of disease activity and damage in 25 domains, incorporating higher weights for disease manifestations that require treatment urgently or that worsen despite treatment...
February 18, 2018: Arthritis Care & Research
Irving O Estevez-Garcia, Selma Gallegos-Nava, Erika Vera-Pérez, Luis H Silveira, Lucio Ventura-Ríos, Gonzalo Vancini, Cristina Hernández-Díaz, Fausto Sánchez-Muñoz, Martha A Ballinas-Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Rodriguez-Henriquez, Diana Castillo-Martínez, Luis M Amezcua-Guerra
OBJECTIVE: To assess potential associations among serum cytokines and microRNA (miR) levels with ultrasound (US) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout. METHODS: All participants underwent musculoskeletal US and measurements of serum IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IFN-γ, TNF, MCP-1, and ENA-78, as well as miR-146a, miR-155, and miR-223 levels. RESULTS: Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 gouty patients were included...
February 18, 2018: Arthritis Care & Research
Brandi E Stevens, Kathryn S Torok, Suzanne C Li, Nicole Hershey, Megan Curran, Gloria C Higgins, Katharine F Moore, C Egla Rabinovich, Samuel Dodson, Anne M Stevens
OBJECTIVE: To investigate clinical manifestations of juvenile systemic sclerosis (jSSc), including disease characteristics and patient quality of life, through the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry. METHODS: Subjects with jSSc were prospectively enrolled between 2010 and 2013. Diagnosis of jSSc was determined by the enrolling pediatric rheumatologist, with disease onset required prior to age 18. Collected data included demographics, disease characteristics, medication exposure, and quality of life metrics...
February 18, 2018: Arthritis Care & Research
Claire E H Barber, Orit Schieir, Diane Lacaille, Deborah A Marshall, Cheryl Barnabe, Glen Hazlewood, Carter Thorne, Vandana Ahluwalia, Susan J Bartlett, Gilles Boire, Boulos Haraoui, Carol A Hitchon, Edward Keystone, Diane Tin, Janet Pope, Lisa Denning, Vivian Bykerk
OBJECTIVE: To assess adherence to three System-Level Performance Measures in a national early RA (ERA) cohort. METHODS: Patients enrolled in the Canadian Early Arthritis Cohort (2007-2015) who met 1987 or 2010 ACR/EULAR criteria with <1year of symptom duration and ≥1year of follow-up after enrollment were included. Performance measures assessed were: i) the percentage of RA patients seen in yearly follow-up, and number of gaps between visits of >12 or 14 months, ii) the percentage of RA patients treated with a disease-modifying drug (DMARD) and, iii) days from RA diagnosis to initiation of DMARD...
February 16, 2018: Arthritis Care & Research
Hayley McBain, Michael Shipley, Stanton Newman
OBJECTIVE: The overall aims of the study are to (a) establish receipt and provision of self-management support for patients with inflammatory arthritis in the UK; and (b) establish if receipt of self-management support is associated with patient's knowledge, skills and confidence to self-manage. METHODS: Questionnaires for patients and healthcare professionals were sent to members and associates of the National Rheumatoid Arthritis Society (NRAS). Patients completed the Patient Activation Measure (PAM), and questions about receipt of self-management support...
February 13, 2018: Arthritis Care & Research
David Bulbin, Alfred E Denio, Andrea Berger, Jason Brown, Carson Maynard, Tarun Sharma, H Lester Kirchner, William T Ayoub
OBJECTIVE: To pilot a primary care gout management improvement intervention. METHODS: Two large primary care sites were selected: one underwent the intervention, the other, a control, underwent no intervention. The intervention consisted of: engagement of intervention site staff, surveys of provider performance improvement preferences, and onsite live and enduring online education. Electronic Health Record reminders were constructed. Both the intervention and control sites had 3 quality measures assessed monthly: percent of gout patients treated with urate lowering therapy, percent of treated patients monitored with serum urate, and percent of treated patients at target serum urate ≤ 6...
February 13, 2018: Arthritis Care & Research
Jennifer L Barton, Elizabeth Hulen, Allison Schue, Edward H Yelin, Sarah S Ono, Anais Tuepker, Christopher J Koenig
OBJECTIVE: Patient and clinician goal alignment, central to effective patient-centered care, has been linked to improved patient experience and outcomes, but has not been explored in rheumatoid arthritis (RA). This study aimed to explore goal conceptualization among RA patients and clinicians. METHODS: Seven focus groups and one semi-structured interview were conducted with RA patients and clinicians recruited from four rheumatology clinics. An interview guide was developed to explore goal concordance related to RA treatment...
February 13, 2018: Arthritis Care & Research
Betty Hsiao, Sonal Balla, Kristin Mattocks, Liana Fraenkel
OBJECTIVE: The objective of our study was to explore the factors that influence risk tolerance among women from different racial/ethnic groups. METHODS: In-depth individual interviews of Non-Hispanic Black, Non-Hispanic White, and Hispanic women aged 20-45 were conducted by a trained interviewer (S.B.) using a semi-structured interview guide to elicit the factors that influence risk tolerance among minority women. The interviews were audiotaped and professionally transcribed with a final sample size of 36 determined by thematic saturation...
February 13, 2018: Arthritis Care & Research
Ruth Ann Marrie, Carol A Hitchon, Randy Walld, Scott B Patten, James M Bolton, Jitender Sareen, John R Walker, Alexander Singer, Lisa M Lix, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder and schizophrenia in a population-based cohort with rheumatoid arthritis (RA) as compared to an age-, sex- and geographically matched cohort without RA. METHODS: Using population-based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex and region...
February 13, 2018: Arthritis Care & Research
Frank W Roemer, C Kent Kwoh, Tomoko Fujii, Michael J Hannon, Robert M Boudreau, David J Hunter, Felix Eckstein, Markus R John, Ali Guermazi
OBJECTIVE: Aims were to assess (1) structural progression in knees with no/mild radiographic osteoarthritis (ROA) (i.e. Kellgren-Lawrence (K-L) grades 0 to 2) that will undergo knee replacement (KR) during a 5-year period; (2) differences in structural damage on MRI between knees with no/mild ROA vs. those with severe ROA (i.e. K-L 3 and 4) at baseline; and (3) differences in pain levels between those groups. METHODS: All participants who underwent KR from baseline (BL) to 60 months were drawn from the Osteoarthritis Initiative...
February 13, 2018: Arthritis Care & Research
Jeffrey R Curtis, Shuo Yang, Jasvinder A Singh, Fenglong Xie, Lang Chen, Huifeng Yun, Paul Muntner, Shia T Kent, Emily B Levitan, Monika M Safford, Kenneth G Saag, Jie Zhang
BACKGROUND/PURPOSE: The 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol treatment guidelines recommend statins for patients with diabetes aged 40-75 years due to their elevated cardiovascular disease (CVD) risk. We compared the incidence of hospitalized acute myocardial infarction (MI), stroke, and coronary revascularization according to whether patients had diabetes, rheumatoid arthritis (RA), both or neither. METHODS: Using 2006 to 2010 private and public health plan claims, we identified 4 mutually exclusive retrospective cohorts age>40: patients with 1) RA and diabetes; 2) RA only; 3) diabetes only; 4) neither condition...
February 6, 2018: Arthritis Care & Research
Michael J Holland, Michael W Beresford, Brian M Feldman, Jennifer Huggins, Ximena Norambuena, Clovis A Silva, Gordana Susic, Sztajnbok Flavio, Yosef Uziel, Simone Appenzeller, Stacy P Ardoin, Tadej Avcin, Francisco Flores, Beatrice Goilav, Raju Khubchandani, Marissa Klein-Gitelman, Deborah Levy, Angelo Ravelli, Scott E Wenderfer, Jun Ying, Nicolino Ruperto, Hermine I Brunner
OBJECTIVES: To describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (cSLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity. METHODS: Information for the SDI was prospectively collected from 1,048 cSLE patients. For a subset of 559 patients physician-rated damage severity measured by visual analog scale (MD-VASdamage ) was also available...
February 6, 2018: Arthritis Care & Research
Rina S Fox, Linda Kwakkenbos, Marie-Eve Carrier, Sarah D Mills, Shadi Gholizadeh, Lisa R Jewett, Scott C Roesch, Erin L Merz, Shervin Assassi, Daniel E Furst, Karen Gottesman, Maureen D Mayes, Brett D Thombs, Vanessa L Malcarne
OBJECTIVE: Fear of negative evaluation is a common concern among individuals with visible differences but has received limited attention in systemic sclerosis (SSc), which can involve substantial changes to appearance. The Brief Fear of Negative Evaluation Scale (BFNE) was specifically designed to evaluate fear of negative evaluation. There are currently three versions of the BFNE with strong demonstrated measurement properties: two eight-item versions (BFNE-S, BFNE-8) and one 12-item version (BFNE-II)...
February 6, 2018: Arthritis Care & Research
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