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Arthritis Care & Research

Shafay Raheel, Izzat Shbeeb, Cynthia S Crowson, Eric L Matteson
OBJECTIVE: To determine time trends in the incidence and survival of polymyalgia rheumatica (PMR) over a 15 year period in Olmsted County, Minnesota, USA and to examine trends in incidence of PMR in the population by comparing this time period to a previous incidence cohort from the same population base. METHODS: All cases of incident PMR among Olmsted County, Minnesota residents in 2000-2014 were identified to extend the previous 1970-1999 cohort. Detailed review of all individual medical records was performed...
October 21, 2016: Arthritis Care & Research
Angela Brenton-Rule, Nicola Dalbeth, Hylton B Menz, Sandra Bassett, Keith Rome
OBJECTIVE: To determine whether foot and ankle characteristics are associated with falls in people with rheumatoid arthritis (RA). METHODS: Two hundred and one adults with RA were recruited from rheumatology outpatient clinics in Auckland, New Zealand. Clinical characteristics, common fall risk factors, and foot and ankle variables were measured. Participants were prospectively studied for 12 months, to record the occurrence of falls using falls diaries. Logistic regression analysis identified baseline variables which were independent predictors of falls over the 12 months...
October 21, 2016: Arthritis Care & Research
Sumeja Zahirovic, Faizah Siddique
A 55 year-old African American man presented to the Emergency Room with acute-onset fevers, chills, and bilateral thumb pain, swelling, and redness. MRI revealed extensive cellulitis involving bilateral hands and wrists, along with fluid collection and carpal bone erosion on the left. Given concerns for septic arthritis and osteomyelitis, patient underwent surgical debridement revealing an abscess in the wrist without osteomyelitis. Blood cultures grew Pasteurella multocida. Subsequently, patient noted two pet dogs at home, but no history of bites...
October 21, 2016: Arthritis Care & Research
Jiang Yue, James F Griffith, Fan Xiao, Lin Shi, Defeng Wang, Jiayun Shen, Priscilla Wong, Edmund K Li, Martin Li, Tena K Li, Tracy Y Zhu, Vivian W Hung, Ling Qin, Lai-Shan Tam
Objective To compare the bone healing effects of denosumab and alendronate in female rheumatoid arthritis (RA) patients by high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods This is a post-hoc analysis of a randomized-controlled trial (NCT01770106). 40 patients were randomized in a 1:1 ratio to receive either subcutaneous denosumab (60mg) once or oral alendronate (70mg) weekly for 6 months. The size of individual bone erosions and the presence and extent of erosion-associated sclerosis (marginal osteosclerosis) were measured in the second metacarpal head of the non-dominant hand at baseline, 3 and 6 months...
October 21, 2016: Arthritis Care & Research
Louise B Murphy, Teresa J Brady, Michael A Boring, Kristina A Theis, Kamil E Barbour, Jin Qin, Charles G Helmick
OBJECTIVE: Self-management education (SME) programs teach people with chronic conditions skills to manage their health conditions. We examined patterns in SME program participation among US adults with arthritis age ≥ 18 years. METHODS: Respondents with arthritis were those who reported ever being diagnosed with arthritis by a doctor or health care provider. We analyzed 2014 National Health Interview Survey (NHIS) data to estimate: 1) percentage (unadjusted and age-standardized) who ever attended a SME program overall and for selected subgroups, 2) representativeness of SME participants relative to all adults with arthritis, and 3) trends in SME course participation...
October 16, 2016: Arthritis Care & Research
José Inciarte-Mundo, Raimon Sanmarti Sala
No abstract text is available yet for this article.
October 16, 2016: Arthritis Care & Research
Johannes Roth, Viviana Ravagnani, Marina Backhaus, Peter Balint, Alessandra Bruns, George A Bruyn, Paz Collado, Lorenia De la Cruz, Severine Guillaume-Czitrom, Troels Herlin, Cristina Hernandez, Annamaria Iagnocco, Sandrine Jousse-Joulin, Stefano Lanni, Vibke Lilleby, Clara Malattia, Silvia Magni-Manzoni, Consuelo Modesto, Ana Narrodi, Juan-Carlos Nieto, Sarah Ohrndorf, Linda Rossi, Anne-Marit Selvaag, Nanno Swen, Tracy Ting, Nikolay Tzaribachev, Patricia Vega-Fernandez, Jelena Vojinovic, Daniel Windschall, Maria-Antonietta D'Agostino, Esperanza Naredo
Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process...
October 16, 2016: Arthritis Care & Research
Wilfred F Peter, Henrika Cw de Vet, Maarten Boers, Jaap Harlaar, Leo D Roorda, Rudolf W Poolman, Vanessa Ab Scholtes, Martijn Steultjens, Gordon J Hendry, Ewa M Roos, Francis Guillemin, Maria G Benedetti, Lorenzo Cavazzuti, Antonio Escobar, Hanne Dagfinrud, Caroline B Terwee
OBJECTIVE: The Animated Activity Questionnaire (AAQ) assesses activity limitations in patients with hip/knee osteoarthritis (HKOA), and consisting video animations of which patients choose the animation that best matches their own performance. The AAQ has shown good validity and reliability. This study aims to evaluate cross-cultural and construct validity of the AAQ. Methods Cross-cultural validity was assessed using ordinal logistic regression analysis to evaluate Differential Item Functioning (DIF) across 7 languages...
October 16, 2016: Arthritis Care & Research
Alfonse T Masi, Laura Jorgenson, Sally Freels
No abstract text is available yet for this article.
October 16, 2016: Arthritis Care & Research
Cécile M Yelnik, Monica Richey, Virginia Haiduc, Sotiria Everett, Meng Zhang, Doruk Erkan
OBJECTIVE: To determine if a cardiovascular disease prevention (CVD) counseling program for lupus patients decreases the prevalence of CVD risk factors. METHODS: The assessment phase of three-year CVD prevention counseling program included the evaluation of CVD risk factors, diet, exercise habits, and medications. The education phase included discussion of the above risk factors as well as CVD and thrombosis prevention strategies. Patients were prospectively followed every 3-6 months for risk assessment and continued education by a nurse practitioner and a medical doctor...
October 16, 2016: Arthritis Care & Research
Chia-Chun Tseng, Shun-Jen Chang, Wen-Chan Tsai, Tsan-Teng Ou, Cheng-Chin Wu, Wan-Yu Sung, Ming-Chia Hsieh, Jeng-Hsien Yen
OBJECTIVE: Past studies have shown common pathologic characteristics and shared immunologic features between polymyositis (PM) and amyotrophic lateral sclerosis (ALS). To explore the potential relationship between the two diseases, we performed a nationwide cohort study. METHODS: We identified all newly diagnosed PM from Taiwan's Registry of Catastrophic Illness Database between January 1, 1998 and December 31, 2011. Each PM patient was matched to at most 5 control patients from the National Health Insurance Research Database by sex, age, and entry date...
October 9, 2016: Arthritis Care & Research
Leticia A Deveza, Virginia B Kraus, Jamie E Collins, Ali Guermazi, Frank W Roemer, Michael Bowes, Michael C Nevitt, Christoph Ladel, David J Hunter
OBJECTIVE: To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS: We analysed data from the OA Biomarkers Consortium within the Osteoarthritis Initiative (n=600). Bone marrow lesions (BMLs), osteophytes, subchondral bone area (mm(2) ) and shape (position on 3D vector) were assessed on MRIs and bone trabecular integrity (BTI) was assessed on radiographs. Serum (s) and urinary (u) markers (sCTX-I, sNTX-I, uNTX-I, uCTX-II, uCTX-I alpha and beta) were measured...
October 9, 2016: Arthritis Care & Research
Seza Ozen, Jasmin B Kuemmerle-Deschner, Rolando Cimaz, Avi Livneh, Pierre Quartier, Isabelle Kone-Paut, Andrew Zeft, Steve Spalding, Ahmet Gul, Veronique Hentgen, Sinisa Savic, Ivan Foeldvari, Joost Frenkel, Luca Cantarini, Dony Patel, Jeffrey Weiss, Nina Marinsek, Ravi Degun, Kathleen G Lomax, Helen J Lachmann
OBJECTIVES: Periodic fever syndromes (PFS) are characterised by recurrent attacks of fever and localised inflammation. This study examined the diagnostic pathway and treatments at tertiary centres for FMF, TRAPS and MKD/HIDS. METHODS: PFS specialists at medical centres in the USA, European Union and Eastern Mediterranean participated in a retrospective chart review, providing de-identified data in an electronic case report form. Patients were treated between 2008-2012 with at least 1 year of follow-up, all had clinical and/or genetically proven disease, and were on/eligible for biologic treatment...
October 9, 2016: Arthritis Care & Research
Nicola Veronese, Brendon Stubbs, Caterina Trevisan, Francesco Bolzetta, Marina De Rui, Stefania Maggi, Leonardo Sartori, Estella Musacchio, Sabina Zambon, Egle Perissinotto, Marianna Noale, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: Hyperuricemia (HU) is frequent in older people and associated with several medical conditions. The relationship between HU and physical performance is limited. We aimed to investigate the association between HU and physical performance over a 4.4 year follow-up in the elderly. METHODS: 1,904 community-dwelling older participants were followed for a mean of 4.4 years. HU at baseline was defined using serum uric acid (SUA) concentrations ≥ 6 and 7 mg/dl for women and men, respectively...
October 9, 2016: Arthritis Care & Research
Jenny Brouwer, Rosalie Fleurbaaij, Johanna M W Hazes, Radboud J E M Dolhain, Joop S E Laven
Objective - Subfertility is frequently encountered amongst female rheumatoid arthritis (RA) patients and has been associated with disease activity and anti-rheumatic drugs. However, little is known about the results of the fertility work-up in these women. Our aim was to study the outcome of fertility assessments in subfertile women with RA. Methods - A cross-sectional study was performed in a nationwide cohort of female RA patients who were pregnant or were trying to conceive between 2002 and 2010 (PARA study)...
October 9, 2016: Arthritis Care & Research
Alexandra Ahmet, Vincent Brienza, Audrey Tran, Julie Lemieux, Mary Aglipay, Nick Barrowman, Ciaran Duffy, Johannes Roth, Roman Jurencak
OBJECTIVE: Adrenal suppression (AS), a glucocorticoid (GC) side effect with potentially significant morbidity, is poorly understood. The purpose of our study was to determine frequency, duration and predictors of AS following a gradual taper of GC in children with rheumatologic conditions. METHODS: Prospective observational cohort study was conducted. All patients ≤16 years ready to discontinue GC after >4weeks of therapy were included. Morning cortisol was tested 4 weeks after GC taper to physiologic doses and then repeatedly until normalization...
October 9, 2016: Arthritis Care & Research
Kristina A Theis, Teresa J Brady, Charles G Helmick
No abstract text is available yet for this article.
October 9, 2016: Arthritis Care & Research
Oriana Ciani, Nicola Antonio Pascarelli, Chiara Giannitti, Mauro Galeazzi, Michela Meregaglia, Giovanni Fattore, Antonella Fioravanti
OBJECTIVE: To perform a cost-effectiveness analysis of mud-bath therapy (MBT) in addition to usual treatment compared to usual treatment alone in patients with bilateral knee osteoarthritis (OA). METHODS: An economic evaluation alongside a randomized controlled trial was conducted. Patients were randomly assigned to receive either a 2 weeks cycle of MBT in addition to their usual treatment or to continue routine care alone. The European Quality-of-Life Questionnaire-5 Dimensions (EQ-5D) questionnaire was administered at baseline, 2 weeks, 3, 6, 9, and 12 months...
October 9, 2016: Arthritis Care & Research
Wendy B Katzman, Neeta Parimi, Ziba Mansoori, Lorenzo Nardo, Deborah M Kado, Peggy M Cawthon, Lynn M Marshall, John T Schousboe, Nancy E Lane
OBJECTIVE: Investigate cross-sectional and longitudinal associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS: DISH and kyphosis were assessed in 1500 men from the Osteoporosis in Men (MrOS) study and 1267 women from the Study of Osteoporotic Fractures (SOF). DISH was assessed in baseline lateral spine radiographs, and Cobb angle of kyphosis was measured from baseline and follow-up radiographs, mean 4.6 years later in men, and 3...
October 9, 2016: Arthritis Care & Research
Jonathan G Quicke, Nadine E Foster, Reuben O Ogollah, Peter R Croft, Melanie A Holden
Objective To investigate how attitudes and beliefs about exercise relate to physical activity behaviour in older adults with knee pain attributable to osteoarthritis (OA). Design Secondary data analyses of a randomised controlled trial of exercise interventions (ISRCTN 93634563). Participants were adults over 45 years old with knee pain attributable to OA (n=514). Crude and adjusted cross-sectional and longitudinal associations between baseline i) Self-Efficacy for Exercise (SEE), ii) Positive Outcome Expectations for Exercise (POEE), iii) Negative Outcome Expectations for Exercise (NOEE) and physical activity level at baseline, 3 and 6 months follow-up (measured by the self-report Physical Activity Scale for the Elderly (PASE)) and important increase in physical activity level (from baseline to 6 month follow-up) were investigated using multiple linear and logistic regression...
October 1, 2016: Arthritis Care & Research
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