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Arthritis Care & Research

Tara S Rogers-Soeder, Nancy E Lane, Mona Walimbe, Ann V Schwartz, Irina Tolstykh, David T Felson, Cora E Lewis, Neil A Segal, Michael C Nevitt
OBJECTIVE: Whether diabetes mellitus (DM) is associated with increased risk of knee osteoarthritis is uncertain. We evaluated associations of DM and biomarkers of abnormal glucose metabolism with incident radiographic knee osteoarthritis (RKOA), controlling for body mass index (BMI). METHODS: Participants (mean age 60.6±7.8 years; mean BMI 29.1±4.9 kg/m2 ) were from the Multicenter Osteoarthritis Study (MOST) study and did not have RKOA at baseline (Kellgren and Lawrence [KL] grade <2 bilaterally)...
November 12, 2018: Arthritis Care & Research
Rouan Gaffar, Christian A Pineau, Sasha Bernatsky, Susan Scott, Evelyne Vinet
OBJECTIVE: To determine if SLE offspring exposed in utero to antimalarials have an increased risk of ocular anomalies during childhood versus unexposed SLE offspring. METHODS: We systematically performed searches of PubMed, Embase, and Web of Science databases for original human data on fetal and/or child ocular outcomes following exposure to antimalarials during pregnancy and/or lactation, from their inception until March 2017. RESULTS: 10 cohort studies and 2 randomized controlled trials, ranging in size from 6 to 444 exposed infants studied, and 3 case reports met the inclusion criteria for our systematic review...
November 12, 2018: Arthritis Care & Research
A S Abi-Ghanem, C J Chouairy, Z Meguerian, L Azar
The patient reported pain that started insidiously in his feet and gradually progressed proximally from the lower extremities to the pelvis, spine and chest. He described it as dull and aching, constant and exacerbated by minimal movement and even inspiration. He complained of frequent severe muscle spasms, cramps, progressive weakness and difficulty with ambulation leading to the use of a wheelchair. He also reported being diagnosed with multiple non-traumatic rib fractures. He had seen multiple physicians in the past for his condition and was given a multitude of treatments without effect...
November 10, 2018: Arthritis Care & Research
Iris Navarro-Millán, Shuo Yang, Lang Chen, Huifeng Yun, Aprajita Jagpal, Christie M Bartels, Liana Fraenkel, Monika M Safford, Jeffrey R Curtis
OBJECTIVE: To determine the proportion of primary lipid screening among patients with rheumatoid arthritis (RA) and compare it with patients with diabetes mellitus (DM) and patients with neither RA nor DM. To determine whether primary lipid screening varied according to the healthcare provider (rheumatologist vs. non-rheumatologist). METHODS: We analyzed claims data from United States' private and public health plans from 2006-2010. Eligibility requirements included: 1) continuous medical and pharmacy coverage for ≥12 months (baseline period), and 2) >2 physician diagnoses and relevant medications to define 4 disease categories: RA, DM, RA and DM, or neither condition...
November 10, 2018: Arthritis Care & Research
Yongdong Zhao, Ramesh S Iyer, Lucas Reichley, Assaf P Oron, Nancy E Gove, Averi E Kitsch, Debosmita Biswas, Seth Friedman, Savannah C Partridge, Carol A Wallace
OBJECTIVE: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease. An inexpensive and rapid imaging tool, infrared thermal imaging, was evaluated for its utility to detect active bone lesions in extremities of children with CNO. METHODS: Children with suspected active CNO and healthy controls were enrolled. All subjects underwent infrared thermal imaging of lower extremities. Patients in the CNO group also received an MRI examination. Hyperintensity within bone marrow on a fluid-sensitive T2-weighted MRI sequence was considered confirmatory for inflammation...
November 2, 2018: Arthritis Care & Research
Savannah R Smith, Jeffrey N Katz, Elena Losina
OBJECTIVE: Evaluate the cost-effectiveness of prolonged (35-day) and standard (14-day) duration anticoagulation therapy following total knee arthroplasty (TKA). METHODS: Using Markov modeling, we assessed clinical and economic outcomes of 14-day and 35-day anticoagulation therapy following TKA with rivaroxaban, low molecular weight heparin (LMWH), fondaparinux, warfarin, and aspirin. Incidence of complications of TKA and anticoagulation - DVT, PE, prosthetic joint infection (PJI), and bleeding - were derived from published literature...
October 28, 2018: Arthritis Care & Research
David R Karp, Benjamin F Chong, Judith A James, Cristina Arriens, Mariko Ishimori, Daniel J Wallace, Duanping Liao, Nancy J Olsen
OBJECTIVE: Recruitment to randomized clinical trials is expensive and often falls short of goals, limiting achievement of measurable outcomes. To prepare for a trial in patients with incomplete forms of lupus, a mock recruitment protocol was carried out at four proposed study sites. The objective was to determine levels of interest in patients and to uncover potential barriers to enrollment. METHODS: After obtaining IRB approval, study coordinators approached individuals who generally fit proposed inclusion and exclusion criteria for the trial...
October 28, 2018: Arthritis Care & Research
Pauline Binder-Finnema, Kathryn Dzurilla, Betty Hsiao, Liana Fraenkel
OBJECTIVE: Treat-to-target implementation in rheumatoid arthritis (RA) requires a shared decision making (SDM) process. However, ability to pay is a major determinant of patient choice, but how this factor affects SDM is under explored. METHODS: Visits at four RA clinics during which patients faced a decision to change their treatment were audiotaped between May 2016 and June 2017. Audiotapes were transcribed verbatim and analyzed using qualitative Framework Analysis...
October 28, 2018: Arthritis Care & Research
Martijn A H Oude Voshaar, Zofia Das Gupta, Johannes W J Bijlsma, Annelies Boonen, Jeffrey Chau, Delphine S Courvoisier, Jeffrey R Curtis, Benjamin Ellis, Sofia Ernestam, Laure Gossec, Christine Hale, Jennifer Hornjeff, Katy Y Y Leung, Merav Lidar, Phillip Mease, Kaleb Michaud, Girish M Mody, Mwidimi Ndosi, Christina H Opava, Geraldo R C Pinheiro, Matthew Salt, Enrique R Soriano, William J Taylor, Maria J H Voshaar, Angelique E A M Weel, Maarten de Wit, Nico Wulffraat, Mart A F J van de Laar, Harald E Vonkeman
BACKGROUND: The implementation of value based healthcare (VBHC) in inflammatory arthritis (IA) requires a standardized set of modifiable outcomes and risk-adjustment variables that is feasible to implement worldwide. METHODS: The International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary working group, consisting of 24 experts from six continents, including six patient representatives, to develop a Standard Set of outcomes for IA...
October 24, 2018: Arthritis Care & Research
Ryan T Lewinson, Isabelle A Vallerand, Jeremy M LaMothe, Laurie M Parsons, Alexandra D Frolkis, Mark W Lowerison, Scott B Patten, Cheryl Barnabe
OBJECTIVE: Arthroplasty requirements among patients with psoriatic arthritis (PsA) are not well known. This information is important for clinical and policy stakeholders for health system planning, and may serve as a surrogate for estimating the efficacy of disease-modifying therapy. METHODS: We utilized The Health Improvement Network (THIN), a large general practice medical records database in the United Kingdom to assess rates of primary total arthroplasty among patients with PsA and the general population between the years 1995 and 2010...
October 24, 2018: Arthritis Care & Research
David S Pisetsky, Megan E B Clowse, Lisa G Criscione-Schreiber, Jennifer L Rogers
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that varies markedly in severity and can be difficult to both diagnose and treat (1, 2). Many manifestations of SLE result from well-defined immune mechanisms that drive systemic as well as local inflammation. If not adequately controlled, these manifestations can lead to organ injury and dysfunction (3). Other manifestations of SLE are vague in origin and have an uncertain relationship to inflammation. This article is protected by copyright...
October 24, 2018: Arthritis Care & Research
Candace H Feldman, Jamie Collins, Zhi Zhang, Chang Xu, S V Subramanian, Ichiro Kawachi, Daniel H Solomon, Karen H Costenbader
OBJECTIVE: Azathioprine (AZA) and mycophenolate mofetil (MMF) are frequently used immunosuppressives for moderate-to-severe SLE. We studied longitudinal patterns and predictors of adherence to AZA and MMF in a nationwide U.S. SLE cohort. METHODS: In the Medicaid Analytic eXtract (2000-2010), we identified SLE patients who initiated AZA or MMF (no use in prior 6 months) with >12 months of continuous follow-up. We dichotomized adherence at 80% with >24/30 days/month considered adherent...
October 24, 2018: Arthritis Care & Research
Michele Maiers, Jan Hartvigsen, Roni Evans, Kristine Westrom, Qi Wang, Craig Schulz, Brent Leininger, Gert Bronfort
OBJECTIVE: Back and neck pain are associated with disability and loss of independence in older adults. It's unknown whether long-term management using commonly recommended treatments is superior to shorter-term treatment. This randomized clinical trial compared short-term treatment (12 weeks) versus long-term management (36 weeks) of back and neck related disability in older adults using spinal manipulative therapy (SMT) combined with supervised rehabilitative exercises (SRE). METHODS: Eligible participants were age 65 and older with back and neck disability for more than 12 weeks...
October 24, 2018: Arthritis Care & Research
Sofia Ramiro, Désirée van der Heijde, Alexandre Sepriano, Miranda van Lunteren, Anna Moltó, Antoine Feydy, Maria Antonietta d'Agostino, Damien Loeuille, Maxime Dougados, Monique Reijnierse, Pascal Claudepierre
OBJECTIVES: To analyse the progression of spinal radiographic damage in patients with early axial spondyloarthritis (axSpA). METHODS: AxSpA patients from the DESIR cohort with 5-year spinal (cervical and lumbar) radiographs available (n=549). Two- and 5-year mSASSS progression and development of new syndesmophytes (net change: number of patients with positive change minus number of patients with negative change divided by total number of patients) were assessed in subgroups defined at baseline according to the ASAS axSpA criteria and its arms, mNYC and the presence of syndesmophytes...
October 24, 2018: Arthritis Care & Research
Kanchana Herath, Lydia Contis, Nidhi Aggarwal, Mehret Birru Talabi
The patient had been feeling well and in his usual state of health, when he first noticed increasing rectal drainage. This was followed several days later by malaise and fevers to 40.5 degrees Celsius. He was evaluated at an emergency department, where computed tomography (CT) imaging of the abdomen and pelvis demonstrated sigmoid colon wall thickening, left perianal inflammation, and sinus tract formation concerning for active Crohn's disease. The patient declined admission and was prescribed amoxicillin-clavulanate...
October 24, 2018: Arthritis Care & Research
Patricia Katz, Jinoos Yazdany, Laura Trupin, Stephanie Rush, Charles G Helmick, Louise B Murphy, Cristina Lanata, Lindsey A Criswell, Maria Dall'Era
BACKGROUND: We examined psychometric performance of PROMIS measures in a racially/ethnically, linguistically diverse SLE cohort. METHODS: Data were from the California Lupus Epidemiology Study (CLUES), a multi-racial/ethnic cohort of individuals with physician-confirmed SLE. The majority (n=332) attended in-person research visits that included interviews conducted in English, Spanish, Cantonese, or Mandarin. Up to 12 PROMIS short-forms were administered (depending on language availability)...
October 24, 2018: Arthritis Care & Research
Mette Nørgaard, Troels Herlin
OBJECTIVE: Juvenile idiopathic arthritis (JIA) may cause functional impairment and reduced physical activity. Aim of this study was to relate habits in club-sport, leisure-time and school-educational physical activity (PA) to objectively measured physical activity using accelerometry in patients with JIA and to compare with healthy controls. METHODS: Consecutive patients from the out-patient clinic were included and clinical characteristics, functional ability and exploration of specific habits in club-sport, leisure-time and school-educational PA using a standardized questionnaire were registered and compared to healthy controls...
October 24, 2018: Arthritis Care & Research
Jennifer M Hootman, Kristina A Theis, Kamil E Barbour, Prabasaj Paul, Susan A Carlson
BACKGROUND: Walking is a joint-friendly activity for adults with arthritis. OBJECTIVES: to estimate, among adults with arthritis, the 1) prevalence of leisure and transportation walking overall, by arthritis status, and by sociodemographic and health characteristics, 2) number of total minutes walking per week in each domain, and 3) distributions of walking bout length in minutes METHODS: Data were from the 2010 National Health Interview Survey. Prevalence estimates (% and 95% confidence intervals (CI)) of leisure and transportation walking in the past 7 days and walking bout time in minutes were calculated, as were multivariable (MV) Poisson regression models, accounting for the complex sample design...
October 22, 2018: Arthritis Care & Research
Alessio Bricca, Wolfgang Wirth, Carsten B Juhl, Jana Kemnitz, David J Hunter, C Kent Kwoh, Felix Eckstein, Adam G Culvenor
OBJECTIVE: To examine the impact of physical activity (PA) on cartilage thickness loss in knee osteoarthritis (KOA). METHODS: 689 participants with radiographic KOA (Kellgren/Lawrence grade ≥2) at baseline, from the Osteoarthritis Initiative completed the Physical Activity Scale for the Elderly (PASE) questionnaires at annual intervals over four years. Magnetic resonance imaging-based cartilage thickness change in the medial femorotibial compartment (MFTC) over four years was the main outcome...
October 19, 2018: Arthritis Care & Research
Elizabeth M Badley, Margot Shields, Siobhan O'Donnell, Wendy E Hovdestad, Lil Tonmyr
OBJECTIVE: To establish whether there is a relationship between the frequency and severity of different types of childhood maltreatment and adulthood arthritis. METHODS: Analysis of the 2012 Canadian Community Health Survey - Mental Health (CCHS-MH): 21,889 respondents aged ≥18 years. Severity and frequency of childhood physical abuse (CPA), and childhood sexual abuse (CSA), and the frequency of childhood exposure to intimate partner violence (CEIPV) were assessed by asking about "things that may have happened to you before you were 16 in your school, in your neighborhood, or in your family"...
October 17, 2018: Arthritis Care & Research
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