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Arthritis Care & Research

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https://www.readbyqxmd.com/read/29781587/patients-concerns-and-perceptions-regarding-biologic-therapies-in-ankylosing-spondylitis-insights-from-a-large-scale-survey-of-social-media-platforms
#1
Eldin Dzubur, Carine Khalil, Christopher V Almario, Benjamin Noah, Deeba Minhas, Mariko Ishimori, Corey Arnold, Yujin Park, Jonathan Kay, Michael H Weisman, Brennan M R Spiegel
OBJECTIVE: Few studies have examined ankylosing spondylitis (AS) patients' concerns and perceptions of biologic therapies outside of traditional surveys. In this study, we used social media data to examine AS patients' knowledge, attitudes, and beliefs regarding biologic therapies. METHODS: We collected posts from 601 social media sites made between 1/1/06-4/26/17. Each post mentioned both an AS keyword and a biologic. To explore themes within the collection in an unsupervised manner, a latent Dirichlet allocation topic model was fit to the dataset...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781581/brain-correlates-of-continuous-pain-in-rheumatoid-arthritis-as-measured-by-pulsed-arterial-spin-labeling
#2
Yvonne C Lee, Alexander Fine, Ekaterina Protsenko, Elena Massarotti, Robert R Edwards, Ishtiaq Mawla, Vitaly Napadow, Marco L Loggia
OBJECTIVE: Central nervous system pathways involving pain modulation shape the pain experience in patients with chronic pain. Our objectives were to understand the mechanisms underlying pain in rheumatoid arthritis (RA) and identify brain signals that may serve as imaging markers for developing targeted treatments for RA pain. METHODS: Subjects with RA and matched controls underwent functional magnetic resonance imaging, using pulsed arterial spin labeling (pASL)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781580/neuromuscular-electrical-stimulation-compared-to-volitional-exercise-in-improving-muscle-function-in-rheumatoid-arthritis-a-randomized-pilot-study
#3
Sara R Piva, Samannaaz S Khoja, Frederico G S Toledo, Mary Chester Wasko, G Kelley Fitzgerald, Bret H Goodpaster, Clair N Smith, Anthony Delitto
OBJECTIVES: To compare the feasibility and effectiveness of Neuromuscular Electrical Stimulation (NMES) with high-intensity volitional resistance training in improving muscle structure and function, and physical function in patients with rheumatoid arthritis (RA). We also described pre- and post-intervention values of myocyte characteristics. METHODS: Two-group single-blinded pilot randomized study in adults with RA. Participants were assigned to 36 sessions over 16 weeks of NMES (n=31) or volitional training (n=28)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781579/poverty-neighborhoods-persistent-stress-and-sle-outcomes-a-qualitative-study-of-the-patients-perspective
#4
Edward Yelin, Laura Trupin, Jared Bunde, Jinoos Yazdany
OBJECTIVE: To obtain the perspective of individuals with SLE about the role of poverty, neighborhood, and chronic stress in SLE outcomes. METHODS: 723 persons with SLE were followed from 2003-2015 through annual structured interviews as part of the Lupus Outcomes Study to establish the effect of combinations of poverty, persistent poverty, living in an area of concentrated poverty, access to health care, and chronic stress on accumulated damage. We sampled 28 from the 723 on the basis of household income, geography, and outcomes in their last interview, and administered qualitative interviews to explore their perspectives on these factors on outcomes...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781577/-googling-gout-exploring-perceptions-about-gout-through-a-linguistic-analysis-of-online-search-activities
#5
Kayla N Jordan, James W Pennebaker, Keith J Petrie, Nicola Dalbeth
AIMS: To understand what terms people seeking information about gout use most frequently in online searches and explore the psychological and emotional tone of these searches. METHODS: A large de-identified dataset of search histories from major search engines was analyzed. Participants who searched for gout (n=1,117), arthritis (arthritis search control group, n=2,036, age and sex-matched), and a random set of age and sex-matched participants (general control group, n=2,150) were included...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781576/ultrasonography-for-the-assessment-of-skin-in-systemic-sclerosis-a-systematic-review
#6
Tânia Santiago, Mariana Santiago, Barbara Ruaro, Maria João Salvador, Maurizio Cutolo, J A P da Silva
OBJECTIVE: To identify and synthesise the best available evidence on the use of ultrasound to assess skin involvement in systemic sclerosis (SSc). METHODS: We conducted a systemic review of the literature on Pubmed MEDLINE and Embase, using the vocabulary terms: ('systemic sclerosis OR scleroderma') AND ('ultrasonography' OR 'Elasticity Imaging Techniques') AND ('skin' OR 'dermis'). Two independent reviewers selected articles, collected data from studies and carried out a manual search of the references from the studies included...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29741284/novel-approach-to-estimate-osteoarthritis-progression-use-of-the-reliable-change-index-in-the-evaluation-of-joint-space-loss
#7
Camille Parsons, Andrew Judge, Kirsten Leyland, Olivier Bruyère, Florence Petit Dop, Roland Chapurlat, Jean-Yves Reginster, Mark Edwards, Elaine Dennison, Cyrus Cooper, Hazel Inskip
OBJECTIVE: Osteoarthritis-related changes in joint space measurements over time are small and sensitive to measurement error. The Reliable Change (RC) index determines whether the magnitude of change observed in an individual can be attributed to true change. This study aimed to examine the RC index as a novel approach to estimating osteoarthritis progression. METHODS: Data from 167 men and 392 women with knee osteoarthritis (diagnosed using the ACR criteria) randomised to the placebo arm of the 3-year Strontium Ranelate Efficacy in Knee Osteoarthritis triAl (SEKOIA) and assessed annually...
May 9, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29741230/a-randomized-controlled-trial-to-evaluate-an-internet-based-self-management-program-in-systemic-sclerosis
#8
Dinesh Khanna, Jennifer Serrano, Veronica J Berrocal, Richard M Silver, Pedro Cuencas, Sharon L Newbill, Josephine Battyany, Cynthia Maxwell, Mary Alore, Laura Dyas, Robert Riggs, Kerri Connolly, Saville Kellner, Jody J Fisher, Erica Bush, Anjali Sachdeva, Luke Evnin, Dennis W Raisch, Janet L Poole
OBJECTIVES: A pilot study showed that an internet-based self-management program improves self-efficacy in systemic sclerosis (SSc). The objective of the present study was to compare the internet-based self-management program to an educational book developed for people with SSc in measures of self-efficacy and other patient-reported outcomes. METHODS: A 16-week randomized, controlled trial. RESULTS: Of the 267 participants who completed baseline questionnaires and were randomized to the intervention (internet) or control (book) condition, 123 (93%) in the internet and 124 (94%) in the control completed the 16-week RCT...
May 9, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29741228/sle-patients-show-an-increased-arterial-stiffness-that-is-predicted-by-igm-anti-%C3%A3-2-glycoprotein-i-and-small-dense-hdl-particles
#9
Sandra Parra, Miguel Lopez-Dupla, Daiana Ibarretxe, Mercedes de Las Heras, Nuria Amigó, Alba Català, Marc Benavent, Esperanza Garcés, Alvaro Navarro, Antoni Castro
BACKGROUND: Patients with systemic lupus erythematous (SLE) show increased cardiovascular mortality and morbidity. The accelerated atherosclerosis observed in SLE patients has been measured by the carotid intima media thickness (c-IMT) and functional vascular tests, such as the arterial stiffness that occurs before plaque formation. AIMS: To investigate the metabolic and immunological factors associated with the presence of central arterial stiffness measured by the augmentation index (AIx)...
May 9, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29740985/obesity-independently-associates-with-worse-patient-reported-outcomes-in-women-with-systemic-lupus-erythematosus
#10
Sarah L Patterson, Gabriela Schmajuk, Kashif Jafri, Jinoos Yazdany, Patricia Katz
BACKGROUND: We aimed to determine whether obesity in women with systemic lupus erythematosus (SLE) independently associates with worse patient-reported outcomes (PROs). METHODS: Data derive from a prospective study of adult women who carried a diagnosis of SLE verified by medical record review. Two established definitions for obesity were used: fat mass index (FMI) ≥ 13 kg/m2 and BMI ≥ 30 kg/m2 . Dependent variables included 4 validated PROs: disease activity via Systemic Lupus Activity Questionnaire (SLAQ), depressive symptoms via Center for Epidemiologic Studies Depression Scale (CES-D), pain via Short Form 36 Health Survey (SF-36) Pain Subscale, and fatigue via SF-36 Vitality Subscale...
May 8, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29726637/sleep-disturbance-and-depression-symptoms-mediate-the-relationship-between-pain-and-cognitive-dysfunction-in-lupus-patients
#11
Teresa A Lillis, Vanessa Tirone, Nisarg Gandhi, Stacy Weinberg, Ailda Nika, Winston Sequeira, Stevan E Hobfoll, Joel A Block, Meenakshi Jolly
OBJECTIVE: The current study explored whether sleep disturbance and depression symptoms mediated the relationship between pain and Cognitive Dysfunction (CD) in a sample of 115 patients with Systemic Lupus Erythematosus (SLE). METHODS: 115 consenting SLE patients completed questionnaires on pain, perceived stress, depression, sleep, and CD. Relationships among pain, sleep, depression and CD were assessed with bootstrapped mediation models controlling for race/ethnicity, fibromyalgia diagnosis, current corticosteroid use, disease activity and damage, and perceived stress...
May 4, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29726627/relationship-between-patient-reported-swelling-and-mri-defined-effusion-synovitis-in-patients-with-meniscus-tears-and-knee-osteoarthritis
#12
Lindsey A MacFarlane, Heidi Yang, Jamie E Collins, Ali Guermazi, Lisa A Mandl, Brue A Levy, Robert G Marx, Clare E Safran-Norton, Elena Losina, Jeffrey N Katz
OBJECTIVE: Synovitis is a prevalent feature in patients with knee osteoarthritis (OA) and meniscal tear and is associated with pain and cartilage damage. Patient-reported swelling is also prevalent in this population. We aimed to investigate the cross-sectional association between patient-reported swelling and effusion-synovitis on magnetic resonance imaging (MRI) in patients with OA and meniscal tear. METHODS: We used baseline data from a multicenter randomized controlled trial, Meniscal Tear in Osteoarthritis Research (MeTeOR)...
May 4, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29707921/obesity-weight-loss-and-progression-of-disability-in-rheumatoid-arthritis
#13
Joshua F Baker, Bryant R England, Ted R Mikuls, Harlan Sayles, Grant W Cannon, Brian C Sauer, Michael D George, Liron Caplan, Kaleb Michaud
BACKGROUND: Obese patients with rheumatoid arthritis (RA) report greater disability in cross-sectional studies. The longitudinal effects of obesity, however, are not well-characterized. We evaluated associations between obesity, weight loss, and worsening of disability in two large registry studies with long-term follow-up. METHODS: This study included patients with RA from the National Data Bank of Rheumatic Diseases (Forward) (N=23,323) and the Veterans Affairs RA (VARA) registry study (N=1,697)...
April 29, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29696833/tofacitinib-in-rheumatoid-arthritis-lack-of-early-change-in-disease-activity-predicts-a-low-probability-of-achieving-low-disease-activity-at-month-6
#14
Ronald F Van Vollenhoven, Eun Bong Lee, Lara Fallon, Samuel H Zwillich, Bethanie Wilkinson, Douglass Chapman, Ryan Demasi, Edward Keystone
OBJECTIVE: Optimal targeted treatment in rheumatoid arthritis requires early identification of failure to respond. This post-hoc analysis explored the relationship between early disease activity changes and achievement of low disease activity (LDA) and remission targets with tofacitinib. METHODS: Data were from two randomized, double-blind, Phase 3 studies. In ORAL Start (NCT01039688), methotrexate (MTX)-naïve patients received tofacitinib 5 or 10 mg BID, or MTX, for 24 months...
April 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29696812/effects-of-aerobic-and-resistance-exercise-in-older-adults-with-rheumatoid-arthritis-a-randomized-controlled-trial
#15
Elvira Lange, Daniel Kucharski, Sara Svedlund, Karin Svensson, Gunhild Bertholds, Inger Gjertsson, Kaisa Mannerkorpi
OBJECTIVE: To evaluate the effect of a person-centered, moderate-to-high intensity, aerobic and resistance exercise protocol on older adults with rheumatoid arthritis (RA), through a randomized controlled multi-center trial. METHODS: Older adults (65-75 years) with RA (n=74) were randomized to either a 20-week person-centered exercise intervention at a gym (n=36) or to home-based exercise of light intensity (n=38). Assessments were performed at baseline, at 20 weeks, and at 12 months...
April 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29693328/american-college-of-rheumatology-provisional-criteria-for-global-flares-in-childhood-onset-systemic-lupus-erythematosus
#16
Hermine I Brunner, Michael Holland, Michael W Beresford, Stacy P Ardoin, Simone Appenzeller, Clovis A Silva, Francisco Flores, Beatrice Goilav, Scott E Wenderfer, Deborah M Levy, Angelo Ravelli, Raju Khunchandani, Tadej Avcin, Marisa S Klein-Gitelman, Brian M Feldman, Nicolino Ruperto, Jun Ying
OBJECTIVE: To validate the preliminary criteria of global flare for childhood-onset SLE (cSLE). METHODS: Pediatricians experienced in cSLE care (n = 268) rated unique patient profiles; results of standard cSLE laboratory testing and information about the cSLE flare descriptors were presented as follows: global assessment of patient well-being, physician global assessment of disease activity (MD-global), Disease Activity Index score, protein/creatinine ratio (PCR), and erythrocyte sedimentation rate (ESR)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29693320/gender-differences-in-quality-of-life-in-patients-with-systemic-lupus-erythematosus
#17
Meenakshi Jolly, Winston Sequeira, Joel A Block, Sergio Toloza, Ana Bertoli, Ivanna Blazevic, Luis M Vila, Ioana Moldovan, Karina D Torralba, Davide Mazzoni, Elvira Cicognani, Sarfaraz Hasni, Berna Goker, Seminur Haznedaroglu, Josiane Bourre-Tessier, Sandra V Navarra, Chi Chiu Mok, Michael Weisman, Ann E Clarke, Daniel Wallace, Graciela Alarcon
Systemic Lupus Erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex; complicated further by unique concerns depending on gender defined roles. Herein, we describe gender differences in disease specific quality of life (QOL) assessment scores using LupusPRO in a large International study. METHODS: Cross-sectional data from 1,803 SLE patients on demographics, self-identified gender status, LupusPRO and disease activity were analyzed. LupusPRO has two constructs: health-related QOL (HRQOL) and non-HRQOL...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29692005/an-extension-study-of-pf-05280586-a-potential-rituximab-biosimilar-versus-rituximab-in-subjects-with-active-rheumatoid-arthritis
#18
Stanley B Cohen, Rubén Burgos-Vargas, Paul Emery, Bo Jin, Carol Cronenberger, María-Dolores Vázquez-Abad
OBJECTIVE: This extension study provided continued treatment to subjects with active rheumatoid arthritis who had participated for ≥16 weeks in a pharmacokinetic similarity study of PF-05280586 (potential rituximab biosimilar). Objectives were to evaluate overall pharmacokinetics, pharmacodynamics, immunogenicity, safety, and tolerability of PF-05280586 after transition from a licensed rituximab product to PF-05280586, and followup of biomarker and efficacy assessments. METHODS: Subjects were offered ≤3 additional courses of treatment of PF-05280586, with or without a single transition from rituximab EU (rituximab-EU) or US (rituximab-US) to PF-05280586...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29692001/all-cause-and-cause-specific-mortality-in-granulomatosis-with-polyangiitis-a-population-based-study
#19
Ju Ann Tan, Hyon K Choi, Hui Xie, Eric C Sayre, John M Esdaile, J Antonio Aviña-Zubieta
OBJECTIVE: To investigate all-cause and cause-specific mortality in patients with newly diagnosed granulomatosis with polyangiitis (GPA) between two calendar time periods, 1997-2004 and 2005-2012. METHODS: Using an administrative health database, we compared all incident cases of GPA to non-GPA controls matched based on sex, age and entry time. Study cohorts were divided into two sub-groups based on the year of diagnosis (i.e., early cohort 1997-2004 and late cohort 2005-2012)...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29691998/a-novel-method-to-combine-assessment-of-benefit-and-harm-omeract-3x3-methodology-applied-to-two-active-comparator-trials
#20
Maarten Boers, Jasvinder A Singh, Stacey S Cofield, S Louis Bridges, Larry W Moreland, James R O'Dell, Hongsheng Wu, Sarah Leatherman, Jeffrey R Curtis
INTRODUCTION: The Outcome Measures in Rheumatology (OMERACT) '3x3' method analyzes the occurrence of benefit and harm simultaneously at the individual patient level. We applied this method to two recent rheumatoid arthritis (RA) trial datasets. METHODS: Treatment of Early Aggressive RA (TEAR) and the RA Comparison of Active Therapies (RACAT) randomized trial outcomes for safety were defined according to OMERACT as no events, non-serious events, and serious events...
April 25, 2018: Arthritis Care & Research
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