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Arthritis Care & Research

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https://www.readbyqxmd.com/read/28732151/patients-attitudes-and-experiences-of-disease-modifying-anti-rheumatic-drugs-in-rheumatoid-arthritis-and-spondyloarthritis-a-qualitative-synthesis
#1
Ayano Kelly, Kathleen Tymms, David J Tunnicliffe, Daniel Sumpton, Chandima Perera, Kieran Fallon, Jonathan C Craig, Walter Abhayaratna, Allison Tong
OBJECTIVES: Non-adherence to disease-modifying anti-rheumatic drugs (DMARDS) in rheumatoid arthritis (RA) and spondyloarthritis (SpA) results in increased disease activity and symptoms and poorer quality of life. We aimed to describe patients' attitudes and experiences of DMARDs in RA and SpA to inform strategies to improve medication adherence. METHODS: Databases (MEDLINE, Embase, PsycINFO, CINAHL) were searched to January 2016. Thematic synthesis was used to analyze the findings...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28732148/trends-of-hospitalization-for-serious-infections-in-patients-with-rheumatoid-arthritis-in-the-us-between-1993-and-2013
#2
Sadao Jinno, Na Lu, S Reza Jafarzadeh, Maureen Dubreuil
BACKGROUND/OBJECTIVE: Epidemiology of hospitalizations with infection among patients with rheumatoid arthritis (RA) is unknown despite an increase in RA treatments that confer infection risk. METHODS: We examined National Inpatient Sample data from 1993-2013. We identified adults RA hospitalizations, defined by having ICD-9-CM codes (714.xx) in any secondary diagnosis field. We evaluated 5 infections as the primary diagnosis: pneumonia, sepsis, urinary tract infection (UTI), skin and soft tissue infections (SSTI), and opportunistic infections (OIs)...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28732147/financial-incentives-and-health-coaching-to-improve-physical-activity-following-total-knee-replacement-a-randomized-controlled-trial
#3
Elena Losina, Jamie E Collins, Bhushan R Deshpande, Savannah R Smith, Griffin L Michl, Ilana M Usiskin, Kristina M Klara, Amelia R Winter, Heidi Y Yang, Faith Selzer, Jeffrey N Katz
OBJECTIVE: Most persons who undergo total knee replacement (TKR) do not increase their physical activity following surgery. We assessed whether financial incentives and health coaching would improve physical activity in persons undergoing TKR. METHODS: We designed a factorial randomized controlled trial among persons undergoing TKR for osteoarthritis. Subjects underwent normal perioperative procedures, including post-operative physical therapy, and were assigned to one of four arms: attention control, telephonic health coaching (THC), financial incentives (FI), or THC+FI...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28732137/prevalence-of-sacroiliitis-in-inflammatory-bowel-disease-using-a-standardized-ct-scoring-system
#4
Jonathan Chan, Ismail Sari, David Salonen, Mark S Silverberg, Nigil Haroon, Robert D Inman
OBJECTIVES: There is an increasing emphasis on early identification and treatment of ankylosing spondylitis (AS) of which the hallmark is sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk of AS and often receive CT scans of their abdomen affording clinicians the opportunity to determine the presence of sacroiliitis. Previous studies using CT have relied only on radiologist's gestalt or a non-validated adaptation of the mNY criteria. Our aim is to assess the prevalence of sacroiliitis in IBD using a validated screening tool and to determine how frequently these patients are referred for rheumatologic evaluation...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28732134/physical-functioning-pain-and-health-related-quality-of-life-in-adults-with-juvenile-idiopathic-arthritis-a-longitudinal-30-year-follow-up-study
#5
Anita Tollisen, Anne M Selvaag, Hanne A Aulie, Vibke Lilleby, Astrid Aasland, Anners Lerdal, Berit Flatø
OBJECTIVES: To describe physical functioning, pain, and health-related quality of life (HRQOL) in adults with Juvenile idiopathic arthritis (JIA), investigate changes over time, and identify predictors of poorer HRQOL after 30 years of disease duration. METHODS: Patients (N=176) clinically examined after 15 years were reassessed with the Health Assessment Questionnaire Disability Index (HAQ-DI), Visual Analogue Scale Pain (VAS pain) and Medical Outcome Study 36-item Short Form (SF-36) after 23 and 30 years...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28704603/relationship-between-knee-pain-and-infra-patellar-fat-pad-morphology-a-within-and-between-person-analysis-from-the-osteoarthritis-initiative
#6
Eva Steidle-Kloc, Adam G Culvenor, Jan Dörrenberg, Wolfgang Wirth, Anja Ruhdorfer, Felix Eckstein
OBJECTIVE: Inflammation is known to be strongly associated with knee pain in osteoarthritis. The infra-patellar fat pad represents a potential source of pro-inflammatory cytokines. Yet, the relationship between infra-patellar fat pad morphology and osteoarthritis symptoms is unclear. METHODS: Here we investigate quantitative imaging parameters of infra-patellar fat pad morphology between: a) painful vs. contralateral pain-free limbs of subjects with unilateral pain; and b) knees of patients with chronic knee pain vs...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28704600/comparable-rates-of-glucocorticoid-associated-adverse-events-in-patients-with-polymyalgia-rheumatica-and-comorbidities-in-the-general-population
#7
Izzat Shbeeb, Divya Challah, Shafay Raheel, Cynthia S Crowson, Eric L Matteson
OBJECTIVE: To investigate the use of glucocorticoids (GC) and related adverse events (AE) in a long-term, geographically-defined cohort of patients with polymyalgia rheumatica (PMR). METHODS: Using a population-based inception cohort, details of GC therapy were abstracted from medical records of all patients diagnosed with PMR in 2000-2014. Age- and sex-matched comparators without PMR were identified from the same underlying population. Cumulative and daily dosage of GC, rate of disease relapse, occurrence of GC-related AE, and rate of GC discontinuation were analyzed...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28704599/anti-tif1-gamma-antibodies-are-not-associated-with-other-paraneoplastic-rheumatic-syndromes-than-dermatomyositis
#8
Paulius Venalis, Sandra Selickaja, Karin Lundberg, Rita Rugiene, Ingrid E Lundberg
OBJECTIVES: An association between cancer and dermatomyositis (DM) is well recognized. The high frequency of malignancies detected close to DM diagnosis suggests that DM can be a paraneoplastic syndrome. Recently anti-TIF1-gamma has been discovered to be associated with cancer and DM. A meta-analysis claimed pooled sensitivity of anti-p155 for diagnosing cancer-associated DM to be 78% and specificity to be 89%. Thus anti-TIF1-gamma has shown promising results as a marker forcancer-associated DM ...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28704598/a-restrictive-use-of-oral-glucocorticoids-in-systemic-lupus-erythematosus-prevents-damage-without-worsening-long-term-disease-control-an-observational-study
#9
Ioana Ruiz-Arruza, Jesús Lozano, Ivan Cabezas-Rodriguez, Jose-Alejandro Medina, Amaia Ugarte, José-Gabriel Erdozain, Guillermo Ruiz-Irastorza
OBJECTIVE: To analyse the influence of two different treatment strategies on general and specific damage accrual in patients with SLE. METHODS: Two cohorts were identified according to the responsible physicians: 1.-patients treated at the Autoimmune Diseases Unit (ADU); 2.-patients treated by other members of the Internal Medicine Department (IM). Members of the ADU worked with a protocol including the universal prescription of hydroxychloroquine (HCQ), the use of maximum oral prednisone doses ≤30mg/day and maintenance therapy with ≤5mg/day, by using methyl-prednisolone pulses and/or early immunosuppressants (IS)...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28704581/from-childhood-to-adulthood-disease-activity-trajectories-in-childhood-onset-systemic-lupus-erythematosus
#10
Lily Siok Hoon Lim, Eleanor Pullenayegum, Brian M Feldman, Lillian Lim, Dafna D Gladman, Earl D Silverman
No previous study has studied the longitudinal disease course of childhood-onset SLE (cSLE). OBJECTIVES: 1) To assess distinguishable differences in disease activity trajectories in cSLE patients; 2) To determine baseline factors predictive of disease trajectory membership and 3) To assess if the different disease activity trajectories are associated with different damage trajectories. METHODS: This is a retrospective, longitudinal inception cohort of cSLE patients...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28692794/despite-early-improvement-patients-with-rheumatoid-arthritis-still-have-impaired-grip-force-5-years-after-diagnosis
#11
Maria Rydholm, Christina Book, Ingegerd Wikström, Lennart Jacobsson, Carl Turesson
OBJECTIVE: Objective measures of function are important in rheumatoid arthritis (RA). The objective of this study was to investigate grip strength in patients with early RA. METHODS: An inception cohort of 225 patients with early RA was followed according to a structured protocol. Average and peak grip force values (Grippit; AB Detektor, Gothenburg, Sweden) of the dominant hand were evaluated and compared to the expected, based on age- and sex-specific reference values from the literature...
July 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28692774/developing-and-refining-new-candidate-criteria-for-sle-classification-an-international-collaboration
#12
Sara K Tedeschi, Sindhu R Johnson, Dimitrios Boumpas, David Daikh, Thomas Dörner, David Jayne, Diane Kamen, Kirsten Lerstrøm, Marta Mosca, Rosalind Ramsey-Goldman, Corine Sinnette, David Wofsy, Josef S Smolen, Raymond P Naden, Martin Aringer, Karen H Costenbader
OBJECTIVES: We aimed to define candidate criteria within multi-phase development of SLE classification criteria, jointly supported by EULAR and ACR. Prior steps included item generation and reduction by Delphi exercise, further narrowed to 21 items in a Nominal Group Technique exercise. Our objectives were to apply an evidence-based approach to the 21 candidate criteria, and to develop hierarchical organization of criteria within domains. METHODS: A literature review identified the sensitivity and specificity of the 21 candidate criteria...
July 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28692771/underlying-mechanisms-of-adult-onset-asthma-and-periocular-xanthogranuloma-comment-on-the-article-by-gallo-et-al
#13
LETTER
François Rodrigues, Sophie Georgin Lavialle, Claude Bachmeyer
No abstract text is available yet for this article.
July 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28692770/impact-of-stopping-tumor-necrosis-factor-inhibitors-on-rheumatoid-arthritis-patients-burden-of-disease
#14
Marjan Ghiti Moghadam, Peter M Ten Klooster, Harald E Vonkeman, Eva L Kneepkens, Ruth Klaasen, Jan N Stolk, Ilja Tchetverikov, Simone A Vreugdenhil, Jan M van Woerkom, Yvonne P M Goekoop-Ruiterman, Robert B M Landewé, Piet L C M van Riel, Mart A F J van de Laar, Tim L Jansen
OBJECTIVE: To determine the impact of stopping tumor necrosis factor inhibitor (TNFi) treatment on patient-reported outcomes (PROs) of physical and mental health status, health utility, pain, disability and fatigue in patients with established rheumatoid arthritis (RA). METHODS: In the pragmatic 12-month POET trial, 817 RA patients with ≥6 months of remission or stable low disease activity were randomized 2:1 to stopping or continuing TNFi. In case of flare, TNFi was restarted at the discretion of the rheumatologist...
July 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686817/affect-and-incident-participation-restriction-in-adults-with-knee-osteoarthritis-the-most-study
#15
Molly W Vaughan, Michael P LaValley, David T Felson, Gael I Orsmond, Jingbo Niu, Cora E Lewis, Neil A Segal, Michael C Nevitt, Julie J Keysor
Objective Participation restriction, common among people with knee osteoarthritis (OA), may be influenced by positive and negative affect. We examined the risk of incident participation restriction over 84 months conferred by positive and negative affect among people with knee OA. Methods Participants are from the Multicenter Osteoarthritis Study and had or were at high risk of knee OA. Participation restriction and positive and negative affect were measured with the Late Life Disability Index, Instrumental Role Limitation subscale and the positive affect and depressed mood subscales of the Center for Epidemiological Studies Depression Scale, respectively...
July 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686816/first-line-non-criterial-antiphospholipid-antibody-testing-for-the-diagnosis-of-antiphospholipid-syndrome-in-clinical-practice-a-combination-of-anti-beta2-glycoprotein-i-domain-i-and-phosphatidylserine-dependent-antiprothrombin-antibodies
#16
Hiroyuki Nakamura, Kenji Oku, Olga Amengual, Kazumasa Ohmura, Yuichiro Fujieda, Masaru Kato, Toshiyuki Bohgaki, Shinsuke Yasuda, Tatsuya Atsumi
OBJECTIVE: The aim of this study was to assess the value of a combination of anti-beta2-glycoprotein I domain I antibodies (aDI) and phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) tests for the diagnosis of antiphospholipid syndrome (APS). METHODS: This cross-sectional study involved a cohort of the patients who visited our clinic from April 2005 to March 2013. IgG aDI, IgG aPS/PT, and IgM aPS/PT tests, together with criteria-defined antiphospholipid antibodies (aPL) tests, were performed in all patients...
July 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686813/reply
#17
LETTER
Murray B Urowitz, Dafna D Gladman
No abstract text is available yet for this article.
July 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686812/severity-of-disease-and-not-glucocorticoid-use-determines-outcomes-in-systemic-lupus-in-response-to-the-study-by-sheane-et-al
#18
LETTER
Aryeh M Abeles, Micha Abeles
No abstract text is available yet for this article.
July 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686811/does-glucosamine-chondroitin-sulfate-have-a-long-term-effect-on-the-progression-of-structural-changes-in-knee-osteoarthritis
#19
LETTER
Marcos Edgar Fernández-Cuadros
No abstract text is available yet for this article.
July 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28686802/training-physical-therapists-in-person-centred-practice-for-people-with-osteoarthritis-a-qualitative-case-study
#20
Belinda J Lawford, Clare Delany, Kim L Bennell, Caroline Bills, Janette Gale, Rana S Hinman
OBJECTIVE: To explore physical therapists' experiences with, and the impacts of, a training program in person-centred practice to support exercise adherence in people with knee osteoarthritis. METHODS: A qualitative case study using semi-structured interviews, nested within a clinical trial. Eight Australian physical therapists were interviewed before, and after, training in person-centred practice for people with knee osteoarthritis. Training involved a two-day workshop, skills practice and audit of eight consultations with four patients (per therapist), and a final single-day workshop for audit feedback and consolidation...
July 7, 2017: Arthritis Care & Research
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