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Journal of Developmental Origins of Health and Disease

B L Mah, K G Pringle, L Weatherall, L Keogh, T Schumacher, S Eades, A Brown, E R Lumbers, C T Roberts, C Diehm, R Smith, K M Rae
Adverse pregnancy outcomes including prematurity and low birth weight (LBW) have been associated with life-long chronic disease risk for the infant. Stress during pregnancy increases the risk of adverse pregnancy outcomes. Many studies have reported the incidence of adverse pregnancy outcomes in Indigenous populations and a smaller number of studies have measured rates of stress and depression in these populations. This study sought to examine the potential association between stress during pregnancy and the rate of adverse pregnancy outcomes in Australian Indigenous women residing in rural and remote communities in New South Wales...
January 17, 2019: Journal of Developmental Origins of Health and Disease
A Bansal, C Li, F Xin, A Duemler, W Li, C Rashid, M S Bartolomei, R A Simmons
No abstract text is available yet for this article.
January 15, 2019: Journal of Developmental Origins of Health and Disease
A A Adane, L R Tooth, G D Mishra
While birthweight of offspring is associated with pre-pregnancy body mass index (BMI) and later risk of obesity, its mediating effect between the association of maternal pre-pregnancy BMI and offspring's childhood anthropometrics has rarely been investigated. This study aimed to examine whether offspring birthweight is a mediator in the association between pre-pregnancy BMI and offspring's childhood anthropometrics. The study included 1,618 mother-child pairs from the Australian Longitudinal Study on Women's Health and Mothers and their Children's Health Study...
January 10, 2019: Journal of Developmental Origins of Health and Disease
F E Santiano, L E Zyla, F Campo Verde-Arboccó, C V Sasso, F A Bruna, V Pistone-Creydt, C M López-Fontana, R W Carón
Environmental factors during perinatal life can lead to changes in the mammary gland, making it susceptible to cancer in adulthood. Breastfeeding has a special importance since it takes place at a critical period of growth and development of the newborn. We aimed to analyze if an appropriate lactation protects the offspring against mammary carcinogenesis during adult life and explore the mechanisms involved in the protective effect. One-day-old Sprague-Dawley female rats were randomly distributed in litters of three (L3), eight (L8) or 12 (L12) pups per dam, to induce a differential consumption of breast milk...
January 10, 2019: Journal of Developmental Origins of Health and Disease
M-J Allard, M-E Brochu, J D Bergeron, M Segura, G Sébire
Chorioamnionitis and intrauterine growth retardation (IUGR) are risk factors for cerebral palsy (CP). Common bacteria isolated in chorioamnionitis include group B Streptococcus (GBS) serotypes Ia and III. Little is known about the impact of placental inflammation induced by different bacteria, including different GBS strains. We aimed to test the impact of chorioamnionitis induced by two common GBS serotypes (GBSIa and GBSIII) on growth and neuromotor outcomes in the progeny. Dams were exposed at the end of gestation to either saline, inactivated GBSIa or GBSIII...
January 10, 2019: Journal of Developmental Origins of Health and Disease
D M Olson, S Brémault-Phillips, S King, G A S Metz, S Montesanti, J K Olson, A Hyde, A Pike, T Hoover, R Linder, B Joggerst, R Watts
The preconception, pregnancy and immediate postpartum and newborn periods are times for mothers and their offspring when they are especially vulnerable to major stressors - those that are sudden and unexpected and those that are chronic. Their adverse effects can transcend generations. Stressors can include natural disasters or political stressors such as conflict and/or migration. Considerable evidence has accumulated demonstrating the adverse effects of natural disasters on pregnancy outcomes and developmental trajectories...
January 10, 2019: Journal of Developmental Origins of Health and Disease
K D Mann, L Basterfield, C Wright, K Parkinson, J K Reilly, J J Reilly, A J Adamson, M S Pearce
Birth weight and early growth have been associated with later blood pressure. However, not all studies consistently find a significant reduction in blood pressure with an increase in birth weight. In addition, the relative importance of birth weight and of other lifestyle and environmental factors is often overlooked and the association is rarely studied in adolescents. We investigated early life predictors, including birth weight, of adolescent blood pressure in the Gateshead Millennium Study (GMS). The GMS is a cohort of 1029 individuals born in 1999-2000 in Gateshead in Northern England...
January 9, 2019: Journal of Developmental Origins of Health and Disease
R Moshkovsky, T Wainstock, E Sheiner, D Landau, A Walfisch
Other than obesity, no definitive insights have been gained regarding the apparent association between mode of delivery and long-term endocrine and metabolic outcomes in the offspring. We aimed to determine whether elective cesarean delivery (CD) impacts on long-term endocrine and metabolic morbidity of the offspring. A population-based cohort analysis was performed including all singleton-term deliveries occurring between 1991 and 2014 at a single tertiary medical center. A comparison was performed between children delivered via a non-emergent CD and those delivered vaginally (VD)...
December 27, 2018: Journal of Developmental Origins of Health and Disease
R Tarevnic, F Ornellas, C A Mandarim-de-Lacerda, M B Aguila
We aimed to evaluate the impact of maternal exercise training on the offspring metabolism and body size caused by father obesity. C57BL/6 male 4-week-old mice were fed a high-fat diet (HF father) or control diet (C father), while equal age female mice were fed only a C diet and were separated into two groups: trained (T mother) and non-trained (NT mother), and at 12 weeks of age mice were mated. A continuous swimming protocol was applied for 10 weeks (before and during gestation), and offspring were followed since weaning until sacrifice (at 12 weeks of age)...
December 18, 2018: Journal of Developmental Origins of Health and Disease
B N Radford, V K M Han
Fetal growth restriction (FGR) is a pregnancy condition in which fetal growth is suboptimal for gestation, and this population is at increased risk for type 2 diabetes as adults. In humans, maternal malnutrition and placental insufficiency are the most common causes of FGR, and both result in fetal undernutrition. We hypothesized that maternal nutrient restriction (MNR) in mice will cause FGR and alter glucose metabolism in adult offspring. Pregnant CD-1 mice were subjected to MNR (70% of average ad libitum) or control (ad libitum) from E6...
December 3, 2018: Journal of Developmental Origins of Health and Disease
M Penkler, M Hanson, R Biesma, R Müller
The field of Developmental Origins of Health and Disease (DOHaD) has grown considerably in recent decades and is receiving increasing recognition from health policymakers. Today, DOHaD research aims to offer a comprehensive perspective on health and disease that traces how different life experiences shape health and disease risks over the entire life course. This integrative perspective opens up distinct possibilities for improving health. At the same time, it raises questions regarding the specific social responsibilities of DOHaD as a field and about possible pathways to a socially just and scientifically robust implementation of DOHaD knowledge in society...
November 23, 2018: Journal of Developmental Origins of Health and Disease
M Matsuyama, L F Gomez-Arango, N M Fukuma, M Morrison, P S W Davies, R J Hill
The objective of this study was to investigate the impact of the most commonly cited factors that may have influenced infants' gut microbiota profiles at one year of age: mode of delivery, breastfeeding duration and antibiotic exposure. Barcoded V3/V4 amplicons of bacterial 16S-rRNA gene were prepared from the stool samples of 52 healthy 1-year-old Australian children and sequenced using the Illumina MiSeq platform. Following the quality checks, the data were processed using the Quantitative Insights Into Microbial Ecology pipeline and analysed using the Calypso package for microbiome data analysis...
November 19, 2018: Journal of Developmental Origins of Health and Disease
C K Barha, K G Salvante, M J Jones, P Farré, J Blais, M S Kobor, L Zeng, E Emberly, P A Nepomnaschy
The hypothalamic-pituitary-adrenal axis (HPAA) plays a critical role in the functioning of all other biological systems. Thus, studying how the environment may influence its ontogeny is paramount to understanding developmental origins of health and disease. The early post-conceptional (EPC) period could be particularly important for the HPAA as the effects of exposures on organisms' first cells can be transmitted through all cell lineages. We evaluate putative relationships between EPC maternal cortisol levels, a marker of physiologic stress, and their children's pre-pubertal HPAA activity (n=22 dyads)...
November 15, 2018: Journal of Developmental Origins of Health and Disease
F B Kampmann, L G Grunnet, T I Halldorsson, A A Bjerregaard, C Granstrøm, S M Pires, M Strøm, A A Vaag, I Tetens, S F Olsen
Individuals born small have an increased risk for developing type 2 diabetes. Altered food preferences in these subjects seem to play a role; however, limited evidence is available on the association between being born small-for-gestational-age (SGA) at term and food intake in adolescence. Alterations in leptin, ghrelin and dopamine levels are suggested mechanisms linking SGA with later food intake. From a large prospective Danish National Birth Cohort, we compared dietary intake of adolescents being born SGA with normal-for-gestational-age (NGA) adolescents...
November 13, 2018: Journal of Developmental Origins of Health and Disease
T M van Elten, M D A Karsten, M N M van Poppel, A Geelen, J Limpens, T J Roseboom, R J B J Gemke
There is increasing evidence linking maternal diet and physical activity before and during pregnancy with offspring's cardiovascular health. Although many studies examined this association, the evidence has not been reviewed systematically. We therefore undertook a systematic review to synthesize evidence examining the association of maternal diet and physical activity before and during pregnancy with offspring's blood pressure and vascular health. We systematically searched the databases MEDLINE and EMBASE from inception to June 30, 2017...
November 13, 2018: Journal of Developmental Origins of Health and Disease
Y Q Lee, C E Collins, A Gordon, K M Rae, K G Pringle
Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring kidney structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus)...
November 9, 2018: Journal of Developmental Origins of Health and Disease
C J Bennett, R E Walker, M L Blumfield, J Ma, F Wang, Y Wan, S M Gwini, H Truby
Despite many interventions aiming to reduce excessive gestational weight gain (GWG), it is currently unclear the impact on infant anthropometric outcomes. The aim of this review was to evaluate offspring anthropometric outcomes in studies designed to reduce GWG. A systematic search of seven international databases, one clinical trial registry and three Chinese databases was conducted without date limits. Studies were categorised by intervention type: diet, physical activity (PA), lifestyle (diet + PA), other, gestational diabetes mellitus (GDM) (diet, PA, lifestyle, metformin and other)...
November 9, 2018: Journal of Developmental Origins of Health and Disease
Romy Gaillard, John Wright, Vincent W V Jaddoe
Adverse exposures during fetal life and the postnatal period influence physical, cognitive and emotional development, and predispose to an increased risk of various chronic diseases throughout the life course. Findings from large observational studies in various populations and experimental animal studies have identified different modifiable risk factors in early life. Adverse maternal lifestyle factors, including overweight, unhealthy diet, sedentary behavior, smoking, alcohol consumption and stress in the preconception period and during pregnancy, are the most common modifiable risk factors leading to a suboptimal in-utero environment for fetal development...
November 9, 2018: Journal of Developmental Origins of Health and Disease
Ralph Catalano, Alison Gemmill, Tim Bruckner
The 'DOHaD' literature argues that stressors encountered at age t 'program' individual health at age t+n, and that this programming appears strongest when t defines critical developmental periods including gestation. Accordingly, children of ill-nourished pregnant women suffer greater later life morbidity than do offspring of well-nourished mothers. The possibility that circumstances other than access to nutritious food drive both a mother's diet and fetal development remains, however, a threat to the inference of programming in utero...
November 5, 2018: Journal of Developmental Origins of Health and Disease
K Rajaleid, U Janlert, A Hjern, H Westerlund, A Hammarström
Low birth weight has been shown to be related to increased risk of depression later in life - but the evidence is not conclusive. We examined the association of size at birth with repeatedly measured depressive symptoms in 947 individuals from the Northern Swedish Cohort, a community-based age-homogeneous cohort born in 1965, and followed with questionnaires between ages 16 and 43 (participation rate above 90% in all the surveys). Information on birth size was retrieved from archived birth records. Length of gestation was known for a subsample of 512 individuals (54%)...
October 31, 2018: Journal of Developmental Origins of Health and Disease
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