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Journal of Developmental Origins of Health and Disease

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https://www.readbyqxmd.com/read/28103963/sex-differences-in-early-life-programming-of-the-hypothalamic-pituitary-adrenal-axis-in-humans-suggest-increased-vulnerability-in-females-a-systematic-review
#1
T Carpenter, S M Grecian, R M Reynolds
Fetal glucocorticoid overexposure is a key mechanism linking early development with later-life disease. In humans, low birth weight associates with increased fasting cortisol, hypothalamic-pituitary-adrenal (HPA) axis reactivity, and with cardiovascular risk and cognitive decline. As there are sex differences in these adult diseases, we hypothesized that there may be sex differences in programming of the HPA axis in response to prenatal stressors. We conducted a systematic review following Meta-Analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analysis...
January 20, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28031078/autism-spectrum-traits-and-visual-processing-in-young-adults-with-very-low-birth-weight-the-helsinki-study-of-very-low-birth-weight-adults
#2
E Wolford, A-K Pesonen, K Heinonen, M Lahti, R Pyhälä, J Lahti, P Hovi, S Strang-Karlsson, J G Eriksson, S Andersson, A-L Järvenpää, E Kajantie, K Räikkönen
Visual processing problems may be one underlying factor for cognitive impairments related to autism spectrum disorders (ASDs). We examined associations between ASD-traits (Autism-Spectrum Quotient) and visual processing performance (Rey-Osterrieth Complex Figure Test; Block Design task of the Wechsler Adult Intelligence Scale-III) in young adults (mean age=25.0, s.d.=2.1 years) born preterm at very low birth weight (VLBW; <1500 g) (n=101) or at term (n=104). A higher level of ASD-traits was associated with slower global visual processing speed among the preterm VLBW, but not among the term-born group (P<0...
December 29, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28031075/prenatal-phthalate-exposure-and-8-isoprostane-among-mexican-american-children-with-high-prevalence-of-obesity
#3
V Tran, G Tindula, K Huen, A Bradman, K Harley, K Kogut, A M Calafat, B Nguyen, K Parra, X Ye, B Eskenazi, N Holland
Oxidative stress has been linked to many obesity-related conditions among children including cardiovascular disease, diabetes mellitus and hypertension. Exposure to environmental chemicals such as phthalates, ubiquitously found in humans, may also generate reactive oxygen species and subsequent oxidative stress. We examined longitudinal changes of 8-isoprostane urinary concentrations, a validated biomarker of oxidative stress, and associations with maternal prenatal urinary concentrations of phthalate metabolites for 258 children at 5, 9 and 14 years of age participating in a birth cohort residing in an agricultural area in California...
December 29, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28029335/enhanced-susceptibility-of-ca3-hippocampus-to-prenatal-nicotine-exposure
#4
O O Kalejaiye, M C Gondré-Lewis
The brain is highly susceptible to adverse effects of drugs of abuse during early phases of life. Prenatal nicotine exposure (PNE), a preventable cause of gestational and infant mortality, can alter neuron wiring and induce sustained deficits in attention and learning. Here, a rat model of PNE (embryonic days 7-21) was used to examine the maturing hippocampus, which encodes new memories and processes emotional memory. Components of synaptic signaling were evaluated at postnatal day 14 (P14), a period of prolific synaptogenesis in rats, to determine if glutamatergic transmission-associated molecules are regulated in subregions of hippocampus as early as P14...
December 28, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28027719/childhood-body-mass-index-at-5-5-years-mediates-the-effect-of-prenatal-maternal-stress-on-daughters-age-at-menarche-project-ice-storm
#5
A Duchesne, A Liu, S L Jones, D P Laplante, S King
Early pubertal timing is known to put women at greater risk for adverse physiological and psychological health outcomes. Of the factors that influence girls' pubertal timing, stress experienced during childhood has been found to advance age at menarche (AAM). However, it is not known if stress experienced by mothers during or in the months before conception can be similarly associated with earlier pubertal timing. Prenatal maternal stress (PNMS) is associated with metabolic changes, such as increased childhood adiposity and risk of obesity, that have been associated with earlier menarchal age...
December 28, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28004624/intrauterine-growth-restriction-increases-circulating-mitochondrial-dna-and-toll-like-receptor-9-expression-in-adult-offspring-could-aerobic-training-counteract-these-adaptations
#6
V Oliveira, S D Silva Junior, M H C de Carvalho, E H Akamine, L C Michelini, M C Franco
It has been demonstrated that intrauterine growth restriction (IUGR) can program increase cardiometabolic risk. There are also evidences of the correlation between IUGR with low-grade inflammation and, thus can contribute to development of several cardiometabolic comorbidities. Therefore, we investigated the influence of IUGR on circulating mitochondrial DNA (mtDNA)/Toll-like receptor 9 (TLR9) and TNF-α expression in adult offspring. Considering that the aerobic training has anti-inflammatory actions, we also investigated whether aerobic training would improve these inflammatory factors...
December 22, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27995843/effects-of-birth-weight-sex-and-neonatal-glucocorticoid-overexposure-on-glucose-insulin-dynamics-in-young-adult-horses
#7
O A Valenzuela, J K Jellyman, V L Allen, N B Holdstock, A J Forhead, A L Fowden
In several species, adult metabolic phenotype is influenced by the intrauterine environment, often in a sex-linked manner. In horses, there is also a window of susceptibility to programming immediately after birth but whether adult glucose-insulin dynamics are altered by neonatal conditions remains unknown. Thus, this study investigated the effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics of young adult horses. For the first 5 days after birth, term foals were treated with saline as a control or ACTH to raise cortisol levels to those of stressed neonates...
December 20, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27995841/relationship-between-copper-and-lipids-and-atherogenic-indices-soon-after-birth-in-japanese-preterm-infants-of-32-35-weeks
#8
H Shoji, N Ikeda, C Kojima, T Kitamura, H Suganuma, K Hisata, S Hirayama, T Ueno, T Miida, T Shimizu
Several studies have reported association of altered levels of lipids and some trace elements with risk factors for cardiovascular disease development in adulthood. Accordingly, the present study aimed to determine the relationship among the serum levels of copper (Cu), zinc (Zn), lipids, lipoproteins and apolipoproteins in preterm infants through an assessment of atherogenic indices shortly after birth. Blood samples were collected within 20 min of birth from 45 preterm infants with gestational ages ranging from 32 to 35 weeks...
December 20, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27931267/western-diet-in-the-perinatal-period-promotes-dysautonomia-in-the-offspring-of-adult-rats
#9
R Vidal-Santos, F N Macedo, M N S Santana, V U De Melo, J L de Brito Alves, M R V Santos, L C Brito, E Nascimento, J H Costa-Silva, V J Santana-Filho
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother's diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram...
December 9, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27927260/early-inherited-risk-for-anxiety-moderates-the-association-between-fathers-child-centered-parenting-and-early-social-inhibition-corrigendum
#10
R J Brooker, K M Alto, K Marceau, R Najjar, L D Leve, J M Ganiban, D S Shaw, D Reiss, J M Neiderhiser
No abstract text is available yet for this article.
December 8, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27919310/indicators-of-fetal-growth-and-adult-liver-enzymes-the-bogalusa-heart-study-and-the-cardiovascular-risk-in-young-finns-study
#11
E W Harville, W Chen, L Bazzano, M Oikonen, N Hutri-Kähönen, O Raitakari
Despite the interest in the relationship of fetal exposures to adult cardiovascular disease, few studies have examined indicators of adult fatty liver disease as an outcome. Previous results are inconsistent, and indicate possible variation by sex. Adult liver enzymes [γ-glutamyl transferase (GGT), alanine transaminase (ALT) and aspartase transaminase (AST)] were measured in two cohort studies: the Bogalusa Heart Study (BHS; n=1803) and the Cardiovascular Risk in Young Finns (YF; n=3571) study, which also had ultrasound measures of liver fat (n=2546)...
December 6, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27919304/green-tea-extract-intake-during-lactation-modified-cardiac-macrophage-infiltration-and-amp-activated-protein-kinase-phosphorylation-in-weanling-rats-from-undernourished-mother-during-gestation-and-lactation
#12
E Matsumoto, S Kataoka, Y Mukai, M Sato, S Sato
Maternal dietary restriction is often associated with cardiovascular disease in offspring. The aim of this study was to investigate the effect of green tea extract (GTE) intake during lactation on macrophage infiltration, and activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and serine-threonine kinase Akt (Akt) in the hearts of weanlings exposed to maternal dietary protein restriction. Pregnant Wistar rats were fed control (C) or low-protein diets (LP) throughout gestation. Following delivery, the dams received a control or a GTE-containing control diet during lactation: control diet during gestation and lactation (CC), low-protein diet during gestation and lactation (LPC), low-protein diet during gestation and 0...
December 6, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28051763/maternal-undernutrition-programs-the-apelinergic-system-of-adipose-tissue-in-adult-male-rat-offspring
#13
S Lecoutre, L Marousez, A Drougard, C Knauf, C Guinez, D Eberlé, C Laborie, D Vieau, J Lesage, C Breton
Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant female rats throughout gestation (called FR30), we previously reported that obesity-prone adult male rat offspring displayed hyperleptinemia with modifications in leptin and leptin receptor messenger RNA (mRNA) levels in white adipose tissue (WAT). Apelin is a member of the adipokine family that regulates various aspects of energy metabolism and WAT functionality...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28051762/impact-of-long-term-high-fat-diet-intake-gestational-protein-restricted-offspring-on-kidney-morphology-and-function
#14
V H G Rizzi, L D B Sene, C D B Fernandez, J A R Gontijo, P A Boer
Emerging evidence highlights the far-reaching consequences of high-fat diet (HFD) and obesity on kidney morphological and functional disorders. In the present study, we aim to evaluate the effects of early HFD intake on renal function and morphology in maternal protein-restricted offspring (LP). LP and normal protein-intake offspring (NP) were fed HFD (LPH and NPH, respectively) or standard rodent (LPN and NPN) diet from the 8th to 13th week of age. Blood pressure, kidney function, immunohistochemistry and scanning electron microscopy were analyzed...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27809950/effects-of-prenatal-bisphenol-a-exposure-and-postnatal-overfeeding-on-cardiovascular-function-in-female-sheep
#15
S M J MohanKumar, T D Rajendran, A K Vyas, V Hoang, N Asirvatham-Jeyaraj, A Veiga-Lopez, N B Olivier, V Padmanabhan, P S MohanKumar
Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on the cardiovascular system. Pregnant sheep were given daily subcutaneous injections of corn oil (control) or BPA (0.5 mg/kg/day in corn oil) from day 30 to day 90 of gestation. A subset of female offspring of these dams were overfed to increase body weight to ~30% over that of normal fed controls...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27748235/effect-of-maternal-zinc-supplementation-on-the-cardiometabolic-profile-of-peruvian-children-results-from-a-randomized-clinical-trial
#16
M L Mispireta, L E Caulfield, N Zavaleta, M Merialdi, D L Putnick, M H Bornstein, J A DiPietro
Zinc is an essential micronutrient for the development of the fetal renal, cardiovascular and metabolic systems; however, there is limited evidence of its effects on the postnatal cardiometabolic function. In this study, we evaluated the effect of maternal zinc supplementation during pregnancy on the cardiometabolic profile of the offspring in childhood. A total of 242 pregnant women were randomly assigned to receive a daily supplement containing iron+folic acid with or without zinc. A follow-up study was conducted when children of participating mothers were 4...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27628681/relationships-between-childhood-growth-parameters-and-adult-blood-pressure-the-fels-longitudinal-study
#17
R T Sabo, A Wang, Y Deng, C S Sabo, S S Sun
Previous research has shown that childhood body size is associated with blood pressure in adulthood, and that early and rapid growth rates are correlated with adverse cardiovascular outcomes. Our objectives are to estimate associations between childhood body size growth parameters and adult blood pressure, and to examine the effect of early attainment of critical growth milestones on adult blood pressure, relative to normal or late attainment. Lifetime height and body mass index (BMI) measurements in childhood, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) measurements in adulthood are taken from participants in the Fels Longitudinal Study...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27609670/effects-of-ilex-paraguariensis-yerba-mate-on-the-hypothalamic-signalling-of-insulin-and-leptin-and-liver-dysfunction-in-adult-rats-overfed-during-lactation
#18
E P S Conceição, A R Kaezer, N Peixoto-Silva, I Felzenszwalb, E de Oliveira, E G Moura, P C Lisboa
Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size was reduced to three pups per dam, and litters with 10 pups per dam were used as a control (10 litters each). On postnatal day (PN) 150, EO offspring were subdivided into EO and EO+mate groups (10 animals each), which were treated with water or mate tea [1 g/kg body weight (BW)/day, by gavage], respectively, for 30 days...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27609592/epigenetic-studies-in-developmental-origins-of-health-and-disease-pitfalls-and-key-considerations-for-study-design-and-interpretation
#19
L Yamada, S Chong
The field of Developmental Origins of Health and Disease (DOHaD) seeks to understand the relationships between early-life environmental exposures and long-term health and disease. Until recently, the molecular mechanisms underlying these phenomena were poorly understood; however, epigenetics has been proposed to bridge the gap between the environment and phenotype. Epigenetics involves the study of heritable changes in gene expression, which occur without changes to the underlying DNA sequence. Different types of epigenetic modifications include DNA methylation, post-translational histone modifications and non-coding RNAs...
February 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27609493/effects-of-a-maternal-high-fat-diet-on-offspring-behavioral-and-metabolic-parameters-in-a-rodent-model
#20
S A Johnson, A B Javurek, M S Painter, C R Murphy, C M Conard, K L Gant, E C Howald, M R Ellersieck, C E Wiedmeyer, V J Vieira-Potter, C S Rosenfeld
Maternal diet-induced obesity can cause detrimental developmental origins of health and disease in offspring. Perinatal exposure to a high-fat diet (HFD) can lead to later behavioral and metabolic disturbances, but it is not clear which behaviors and metabolic parameters are most vulnerable. To address this critical gap, biparental and monogamous oldfield mice (Peromyscus polionotus), which may better replicate most human societies, were used in the current study. About 2 weeks before breeding, adult females were placed on a control or HFD and maintained on the diets throughout gestation and lactation...
February 2017: Journal of Developmental Origins of Health and Disease
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