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Journal of Developmental Origins of Health and Disease

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https://www.readbyqxmd.com/read/28343464/life-lifestyle-and-location-examining-the-complexities-of-psychological-distress-in-young-adult-indigenous-and-non-indigenous-australians
#1
B Davison, T Nagel, G R Singh
Mental health is fundamental to an individual's health and well-being. Mental health disorders affect a substantial portion of the Australian population, with the most vulnerable time in adolescence and young adulthood. Indigenous Australians fare worse than other Australians on almost every measure of physical and mental health. Cross-sectional data from young adults (21-27 years) participating in the Life Course Program, Northern Territory, Australia, is presented. Rates of psychological distress were high in remote and urban residing Indigenous and urban non-Indigenous young adults...
March 27, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28343461/the-impact-of-maternal-obesity-on-inflammatory-processes-and-consequences-for-later-offspring-health-outcomes
#2
S A Segovia, M H Vickers, C M Reynolds
Obesity is a global epidemic, affecting both developed and developing countries. The related metabolic consequences that arise from being overweight or obese are a paramount global health concern, and represent a significant burden on healthcare systems. Furthermore, being overweight or obese during pregnancy increases the risk of offspring developing obesity and other related metabolic complications in later life, which can therefore perpetuate a transgenerational cycle of obesity. Obesity is associated with a chronic state of low-grade metabolic inflammation...
March 27, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28337952/prenatal-maternal-stress-shapes-children-s-theory-of-mind-the-qf2011-queensland-flood-study
#3
G Simcock, S Kildea, G Elgbeili, D P Laplante, V Cobham, S King
Research shows that stress in pregnancy has powerful and enduring effects on many facets of child development, including increases in behavior problems and neurodevelopmental disorders. Theory of mind is an important aspect of child development that is predictive of successful social functioning and is impaired in children with autism. A number of factors related to individual differences in theory of mind have been identified, but whether theory of mind development is shaped by prenatal events has not yet been examined...
March 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28327211/reduced-fetal-vitamin-d-status-by-maternal-undernutrition-during-discrete-gestational-windows-in-sheep
#4
J K Cleal, M R Hargreaves, K R Poore, J C Y Tang, W D Fraser, M A Hanson, L R Green
Placental transport of vitamin D and other nutrients (e.g. amino acids, fats and glucose) to the fetus is sensitive to maternal and fetal nutritional cues. We studied the effect of maternal calorific restriction on fetal vitamin D status and the placental expression of genes for nutrient transport [aromatic T-type amino acid transporter-1 (TAT-1); triglyceride hydrolase/lipoprotein uptake facilitator lipoprotein lipase (LPL)] and vitamin D homeostasis [CYP27B1; vitamin D receptor (VDR)], and their association with markers of fetal cardiovascular function and skeletal muscle growth...
March 22, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28300011/neonatal-fatty-acid-profiles-are-correlated-with-infant-growth-measures-at-6-months
#5
P F O'Tierney-Ginn, D Davina, M Gillingham, D J P Barker, C Morris, K L Thornburg
Rapid weight gain in infancy and low levels of n-3 long chain polyunsaturated fatty acids (LCPUFA) at birth are associated with increased adiposity later in life. The association between placental LCPUFA delivery and weight gain in infancy is poorly understood. We sought to determine the relationships between maternal phenotype, placental fatty acid transporter expression and offspring growth patterns over the first 6 months. Placental tissue and cord blood were collected at term delivery from women with uncomplicated pregnancies...
March 16, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28264759/environmental-enteropathy-is-associated-with-cardiometabolic-risk-factors-in-peruvian-children
#6
G O Lee, M Paredes Olortegui, M Siguas Salas, P Peñataro Yori, D Rengifo Trigoso, P Kosek, M L Mispireta, R Oberhelman, L E Caulfield, M N Kosek
Environmental enteropathy (EE) is a syndrome of altered small intestine structure and function hypothesized to be common among individuals lacking access to improved water and sanitation. There are plausible biological mechanisms, both inflammatory and non-inflammatory, by which EE may alter the cardiometabolic profile. Here, we test the hypothesis that EE is associated with the cardiometabolic profile among young children living in an environment of intense enteropathogen exposure. In total, 156 children participating in the Peruvian cohort of a multicenter study on childhood infectious diseases, growth and development were contacted at 3-5 years of age...
March 7, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28264755/maternal-low-protein-diet-in-female-rat-heart-possible-protective-effect-of-estradiol
#7
G R F Braz, A S Emiliano, S M Sousa, A A S Pedroza, D F Santana, M P Fernandes, A I da Silva, C J Lagranha
Several studies have shown that maternal low-protein (LP) diet induces detrimental effects in cardiovascular system and oxidative stress in male animals. Additional studies suggested that female has lower incidence of cardiovascular disease. However until present data, the possible effects of estradiol on the undernutrition during gestational and lactation periods are not discussed. The present study was conducted to evaluate the effects of a maternal LP diet during gestational and lactation period on oxidative balance in the female rat hearts ventricles at two ages...
March 7, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28260562/the-effect-of-paternal-methyl-group-donor-intake-on-offspring-dna-methylation-and-birth-weight
#8
S Pauwels, I Truijen, M Ghosh, R C Duca, S A S Langie, B Bekaert, K Freson, I Huybrechts, G Koppen, R Devlieger, L Godderis
Most nutritional studies on the development of children focus on mother-infant interactions. Maternal nutrition is critically involved in the growth and development of the fetus, but what about the father? The aim is to investigate the effects of paternal methyl-group donor intake (methionine, folate, betaine, choline) on paternal and offspring global DNA (hydroxy)methylation, offspring IGF2 DMR DNA methylation, and birth weight. Questionnaires, 7-day estimated dietary records, whole blood samples, and anthropometric measurements from 74 fathers were obtained...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28260559/umbilical-artery-histomorphometry-a-link-between-the-intrauterine-environment-and-kidney-development
#9
M J DeFreitas, D Mathur, W Seeherunvong, T Cano, C P Katsoufis, S Duara, S Yasin, G Zilleruelo, M M Rodriguez, C L Abitbol
Prematurity is a risk factor for hypertension, vascular stiffness, nephron deficit and adult onset cardiorenal disease. The vascular tree and kidneys share morphogenic drivers that promote maturation in utero before 36 weeks of gestation. Vascular elastin accrual terminates after birth leaving collagen to promote vascular stiffness. Our objective was to determine if the histomorphometry of the umbilical artery, an extension of the aorta, parallels nephron mass across gestational age groups. From a cohort of 54 newborns, 32 umbilical cord specimens were adequate for evaluation...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28260557/the-influence-of-in-vitro-fertilization-and-embryo-culture-on-the-embryo-epigenetic-constituents-and-the-possible-consequences-in-the-bovine-model
#10
M-A Sirard
Medically assisted reproductive technologies, such as in vitro embryo production, are increasingly being used to palliate infertility. Eggs are produced following a hormonal regimen that stimulates the ovaries to produce a large number of oocytes. Collected oocytes are then fertilized in vitro and allowed to develop in vitro until they are either frozen or transferred to mothers. There are controversial reports on the adverse impacts of these technologies on early embryos and their potential long-term effects...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28260556/feasibility-of-collecting-tumor-samples-of-breast-cancer-patients-diagnosed-up-to-50-years-ago-in-the-child-health-and-development-studies
#11
N Y Krigbaum, R A Rubin, P M Cirillo, M B Terry, L A Habel, C Morris, B A Cohn
Environmental exposures during pregnancy may increase breast cancer risk for mothers and female offspring. Tumor tissue assays may provide insight regarding the mechanisms. This study assessed the feasibility of obtaining tumor samples and pathology reports from mothers (F0) who were enrolled in the Child Health and Development Studies during pregnancy from 1959 to 1967 and their daughters (F1) who developed breast cancer over more than 50 years of follow-up. Breast cancer cases were identified through linkage to the California Cancer Registry and self-report...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28196555/dohad-at-the-intersection-of-maternal-immune-activation-and-maternal-metabolic-stress-a-scoping-review
#12
J A Goldstein, S A Norris, D M Aronoff
The prenatal environment is now recognized as a key driver of non-communicable disease risk later in life. Within the developmental origins of health and disease (DOHaD) paradigm, studies are increasingly identifying links between maternal morbidity during pregnancy and disease later in life for offspring. Nutrient restriction, metabolic disorders during gestation, such as diabetes or obesity, and maternal immune activation provoked by infection have been linked to adverse health outcomes for offspring later in life...
February 15, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28173891/early-life-risk-exposure-and-stunting-in-urban-south-african-2-year-old-children
#13
W Slemming, J Kagura, H Saloojee, L M Richter
Stunting is a measure of overall nutritional status and is a major public health concern because of its association with child mortality and morbidity and later adult performance. This study examined the effects of pregnancy events, birth characteristics and infant risk exposure on stunting at age 2 years. The study, established in 1990 in Soweto, an urban South African township, included 1098 mother-infant pairs enroled in the Birth to Twenty Plus longitudinal birth cohort study. In total, 22% of children were stunted at age 2 years, with males at greater risk than females [24...
February 8, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28162133/restricted-nutrition-induced-low-birth-weight-low-number-of-nephrons-and-glomerular-mesangium-injury-in-japanese-quail
#14
H Nishimura, E Yaoita, M Nameta, K Yamaguchi, M Sato, C Ihoriya, L Zhao, H Kawachi, T Sasaki, Y Ikezumi, Y Ouchi, N Kashihara, T Yamamoto
Insufficient nutrition during the perinatal period causes structural alterations in humans and experimental animals, leading to increased vulnerability to diseases in later life. Japanese quail, Coturnix japonica, in which partial (8-10%) egg white was withdrawn (EwW) from eggs before incubation had lower birth weights than controls (CTs). EwW birds also had reduced hatching rates, smaller glomeruli and lower embryo weight. In EwW embryos, the surface condensate area containing mesenchymal cells was larger, suggesting that delayed but active nephrogenesis takes place...
February 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28162120/childhood-body-mass-index-at-5-5-years-mediates-the-effect-of-prenatal-maternal-stress-on-daughters-age-at-menarche-project-ice-storm-erratum
#15
A Duchesne, A Liu, S L Jones, D P Laplante, S King
No abstract text is available yet for this article.
February 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28137344/retinal-microvascular-plasticity-in-a-premature-neonate
#16
Y Kandasamy, L Hartley, R Smith
Dilation and abnormal tortuosity of retinal vessels are the hallmarks of severe retinopathy of prematurity (ROP) in premature infants. The stages of ROP are defined by vessel appearance at the interface between the vascular and avascular retinal areas. Deregulated signaling pathways involving hypoxia-inducible factors such as vascular endothelial growth factor (VEGF) are involved in the pathogenesis of ROP. VEGF-antagonists are increasingly being used as 'off-label medication' to treat this condition, with some success...
January 31, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28115035/age-at-menarche-in-relation-to-prenatal-rainy-season-exposure-and-altitude-of-residence-results-from-a-nationally-representative-survey-in-a-tropical-country
#17
E C Jansen, O F Herrán, N L Fleischer, A M Mondul, E Villamor
Intrauterine exposure to the rainy season in the tropics may be accompanied by high rates of infection and nutritional deficiencies. It is unknown whether this exposure is related to the extrauterine timing of development. Our aim was to evaluate the relations of prenatal exposure to the rainy season and altitude of residence with age at menarche. The study included 15,370 girls 10 to <18 years old who participated in Colombia's 2010 National Nutrition Survey. Primary exposures included the number of days exposed to the rainy season during the 40 weeks preceding birth, and altitude of residence at the time of the survey...
January 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28112071/early-life-programming-and-the-risk-of-non-alcoholic-fatty-liver-disease
#18
C Lynch, C S Chan, A J Drake
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, type 2 diabetes and cardiovascular disease and can be considered the hepatic manifestation of the metabolic syndrome. NAFLD represents a spectrum of disease, from the relatively benign simple steatosis to the more serious non-alcoholic steatohepatitis, which can progress to liver cirrhosis, hepatocellular carcinoma and end-stage liver failure, necessitating liver transplantation. Although the increasing prevalence of NAFLD in developed countries has substantial implications for public health, many of the precise mechanisms accounting for the development and progression of NAFLD are unclear...
January 23, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28112069/placental-11-%C3%AE-hydroxysteroid-dehydrogenase-type-2-11%C3%AE-hsd2-expression-very-early-during-human-pregnancy
#19
K G Salvante, K Milano, H J Kliman, P A Nepomnaschy
Maternal physiologic stress during gestation has been reported to be associated with negative developmental outcomes, including intra-uterine growth restriction and reduced birth weight, which can impact postnatal development, behavior and health. The human fetus is partially protected from elevated cortisol exposure by placental 11 β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which oxidizes bioactive cortisol into bio-inactive cortisone. Importantly, despite the critical protective role hypothesized for 11β-HSD2, the onset of its placental expression has yet to be clearly established...
January 23, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28103963/sex-differences-in-early-life-programming-of-the-hypothalamic-pituitary-adrenal-axis-in-humans-suggest-increased-vulnerability-in-females-a-systematic-review
#20
T Carpenter, S M Grecian, R M Reynolds
Fetal glucocorticoid overexposure is a key mechanism linking early development with later-life disease. In humans, low birth weight associates with increased fasting cortisol, hypothalamic-pituitary-adrenal (HPA) axis reactivity, and with cardiovascular risk and cognitive decline. As there are sex differences in these adult diseases, we hypothesized that there may be sex differences in programming of the HPA axis in response to prenatal stressors. We conducted a systematic review following Meta-Analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analysis...
January 20, 2017: Journal of Developmental Origins of Health and Disease
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