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Journal of Developmental Origins of Health and Disease

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https://www.readbyqxmd.com/read/29769150/adipose-tissue-uncoupling-protein-1-levels-and-function-are-increased-in-a-mouse-model-of-developmental-obesity-induced-by-maternal-exposure-to-high-fat-diet
#1
E Bytautiene Prewit, C Porter, M La Rosa, N Bhattarai, H Yin, P Gamble, T Kechichian, L S Sidossis
With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exposed to prenatal obesity. Female CD-1 mice were fed a high-fat (HF) or standard-fat (SF) diet for 3 months before breeding. After weaning, all pups were placed on SF. UCP1 mRNA and protein levels were quantified using quantitative real-time PCR and Western blot analysis, respectively, in brown (BAT), subcutaneous (SAT) and visceral (VAT) adipose tissues at 6 months of age...
May 17, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29764530/influence-of-maternal-adiposity-preterm-birth-and-birth-weight-centiles-on-early-childhood-obesity-in-an-indigenous-australian-pregnancy-through-to-early-childhood-cohort-study
#2
K G Pringle, Y Q Lee, L Weatherall, L Keogh, C Diehm, C T Roberts, S Eades, A Brown, R Smith, E R Lumbers, L J Brown, C E Collins, K M Rae
Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Related-Optimal Weight (GROW) centiles, maternal adiposity (percentage body fat, visceral fat area), maternal non-fasting plasma glucose levels (measured at mean gestational age of 23...
May 16, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29764525/development-of-understanding-of-dohad-concepts-in-students-during-undergraduate-health-professional-programs-in-japan-and-new-zealand
#3
M Oyamada, A Lim, R Dixon, C Wall, J Bay
Evidence in support of the Developmental Origins of Health and Disease (DOHaD) hypothesis has reached the level where it can appropriately be used to inform practice. DOHaD informed interventions supporting primary noncommunicable disease risk reduction should target the pre- and periconceptional periods, pregnancy, lactation, childhood and adolescence. Such interventions are dependent on a health workforce (including dietitians, nurses, midwives, doctors, and nutrition teachers), that has a deep understanding of DOHaD concepts...
May 16, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29729681/up-regulation-of-renal-renin-angiotensin-system-and-inflammatory-mechanisms-in-the-prenatal-programming-by-low-protein-diet-beneficial-effect-of-the-post-weaning-losartan-treatment
#4
I K M Watanabe, Z P Jara, R A Volpini, M D C Franco, F F Jung, D E Casarini
Previous studies have shown that the renin-angiotensin system (RAS) is affected by adverse maternal nutrition during pregnancy. The aim of this study was to investigate the effects of a maternal low-protein diet on proinflammatory cytokines, reactive oxygen species and RAS components in kidney samples isolated from adult male offspring. We hypothesized that post-weaning losartan treatment would have beneficial effects on RAS activity and inflammatory and oxidative stress markers in these animals. Pregnant Sprague-Dawley rats were fed with a control (20% casein) or low-protein diet (LP) (6% casein) throughout gestation...
May 6, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29720284/update-on-a-meta-analysis-of-sperm-donation-offspring-health-outcomes-2018-update
#5
D H Adams, R A Clark, M J Davies, S de Lacey
No abstract text is available yet for this article.
May 3, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29717680/intergenerational-and-early-life-influences-on-the-well-being-of-australian-aboriginal-and-torres-strait-islander-children-overview-and-selected-findings-from-footprints-in-time-the-longitudinal-study-of-indigenous-children
#6
M Salmon, F Skelton, K A Thurber, L Bennetts Kneebone, J Gosling, R Lovett, M Walter
Footprints in Time: The Longitudinal Study of Indigenous Children (LSIC) is a national study of 1759 Australian Aboriginal and Torres Strait Islander children living across urban, regional and remote areas of Australia. The study is in its 11th wave of annual data collection, having collected extensive data on topics including birth and early life influences, parental health and well-being, identity, cultural engagement, language use, housing, racism, school engagement and academic achievement, and social and emotional well-being...
May 2, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29706142/prenatal-lead-exposure-in-relation-to-age-at-menarche-results-from-a-longitudinal-study-in-mexico-city
#7
E C Jansen, L Zhou, P X K Song, B N Sánchez, A Mercado, H Hu, M Solano, K E Peterson, M M Tellez-Rojo
Animal and cross-sectional epidemiological studies suggest that prenatal lead exposure is related to delayed menarche, but this has not been confirmed in longitudinal studies. We analyzed this association among 200 girls from Mexico City who were followed since the first trimester of gestation. Maternal blood lead levels were analyzed once during each trimester of pregnancy, and daughters were asked about their first menstrual cycle at a visit between the ages of 9.8 and 18.1 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) for probability of menarche over the follow-up period using interval-censored Cox models, comparing those with prenatal blood lead level ⩾5 µg/dl to those with prenatal blood lead <5 µg/dl...
April 30, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29692274/isolating-the-direct-effects-of-adverse-developmental-conditions-on-in-vivo-cardiovascular-function-at-adulthood-the-avian-model
#8
K L Skeffington, C Beck, N Itani, D A Giussani
It is now well accepted that exposure to adverse environmental conditions in utero can predispose a fetus to disease later in life. Using an avian model to study the programming of disease has a unique advantage as it allows isolation of the direct effects of adverse conditions on fetal physiology, without any confounding effects via the mother or placenta. However, experiments in avian models are limited by the lack of well-established surgical protocols for the adult bird, which we have established in this study...
April 25, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29681245/pregnancy-risk-factors-related-to-autism-an-italian-case-control-study-in-mothers-of-children-with-autism-spectrum-disorders-asd-their-siblings-and-of-typically-developing-children
#9
E Grossi, L Migliore, F Muratori
This study, carried out in two Italian Institutions, assesses the frequency of 27 potential autism risk factors related to pregnancy and peri- and postnatal periods by interviewing mothers who had children with autism, children with autism and one or two typically developing siblings, or only typically developing children. The clinical sample included three case groups: 73 children and adolescents with autism (Group A), 35 children and adolescents with autism (Group A1) having 45 siblings (Group B) and 96 typically developing children (Group C) matched for gender and age...
April 23, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29665872/maternal-intake-of-omega-3-and-omega-6-polyunsaturated-fatty-acids-during-mid-pregnancy-is-inversely-associated-with-linear-growth
#10
M Al-Hinai, A Baylin, M M Tellez-Rojo, A Cantoral, A Ettinger, M Solano-González, K E Peterson, W Perng
This study investigates relations of maternal N-3 and N-6 polyunsaturated fatty acids (PUFA) intake during pregnancy with offspring body mass index (BMI), height z-score and metabolic risk (fasting glucose, C-peptide, leptin, lipid profile) during peripuberty (8-14 years) among 236 mother-child pairs in Mexico. We used food frequency questionnaire data to quantify trimester-specific intake of N-3 alpha-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); N-6 linoleic acid and arachidonic acid (AA); and N-6:N-3 (AA:EPA+DHA), which accounts for the fact that the two PUFA families have opposing effects on physiology...
April 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29661258/liver-metabolism-in-adult-male-mice-offspring-consequences-of-a-maternal-paternal-or-both-maternal-and-paternal-high-fructose-diet
#11
P V Carapeto, F Ornellas, C A Mandarim-de-Lacerda, M B Aguila
The study aimed to evaluate the consequences of the consumption of a high-fructose diet (HFR; fructose was responsible for 45% of the energy from carbohydrates) by the mother, the father, or both on C57BL/6 adult male offspring. Non-consanguineous parents received the diet (HFR or control, C) from 8 weeks before mating until weaning (n=10 fathers and n=10 mothers on each diet). After weaning, only the C diet was offered to offspring. The groups were formed by one male randomly taken from each litter. The offspring groups were identified according to the mother's diet (the first letter), then the father's diet (the second letter), that is, C/C, C/HFR, HFR/C, HFR/HFR (n=10 per group)...
April 17, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29644942/postnatal-undernutrition-in-mice-causes-cardiac-arrhythmogenesis-which-is-exacerbated-when-pharmacologically-stressed
#12
J R Visker, D P Ferguson
Growth restriction caused by postnatal undernutrition increases risk for cardiovascular disease in adulthood with the potential to induce arrhythmogenesis. Thus, the purpose was to determine if undernutrition during development produced arrhythmias at rest and when stressed with dobutamine in adulthood. Mouse dams were fed (CON: 20% protein), or low-protein (LP: 8%) diet before mating. A cross-fostering model was used where pups nursed by dams fed LP diet in early [EUN; postnatal day (PN) 1-10], late (LUN; PN11-21) and whole (PUN; 1-21) phases of postnatal life...
April 12, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29631648/associations-between-maternal-prenatal-cortisol-and-fetal-growth-are-specific-to-infant-sex-findings-from-the-wirral-child-health-and-development-study
#13
E C Braithwaite, J Hill, A Pickles, V Glover, K O'Donnell, H Sharp
Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population...
April 10, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29631641/the-transgenerational-effect-of-maternal-and-paternal-f1-low-birth-weight-on-bone-health-of-second-and-third-generation-offspring
#14
K Anevska, J D Wark, M E Wlodek, T Romano
Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and transgenerational origins, whereby transmission to subsequent generations occurs via both parental lines. Uteroplacental insufficiency surgery (Restricted) or sham surgery (Control) was performed on gestational day 18, in F0 Wistar-Kyoto rats. F1 Restricted males and females mated with breeders in order to generate F2 offspring of maternal and paternal lineages. F2 males and females were randomly selected for breeding to generate F3 offspring...
April 10, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29582727/maternal-low-quality-protein-diet-exerts-sex-specific-effects-on-plasma-amino-acid-profile-and-alters-hepatic-expression-of-methyltransferases-in-adult-rat-offspring
#15
A Akyol, A Kabasakal Cetin, A Gulec, H Dasgin, A Ayaz, I Onbasilar
Nutrition during pregnancy and lactation is a critical factor in the development of the offspring. Both protein content and source in maternal diet affect neonatal health, but the long-term effects of maternal low-quality protein diet on the offspring are less clear. This study aimed to examine the effects of maternal low-quality protein diet on offspring's growth, development, circulating metabolites and hepatic expression of methyltransferases. Virgin Wistar rats were mated at 11 weeks of age. Dams were then maintained on either a chow diet with 20% casein as the control group (C), or a low-quality protein diet with 20% wheat gluten as the experimental group (WG) throughout gestation and lactation...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29582717/maternal-protein-malnutrition-effects-on-prostate-development-and-adult-disease
#16
J C Rinaldi, S A A Santos, K T Colombelli, L Birch, G S Prins, L A Justulin, S L Felisbino
Well-controlled intrauterine development is an essential condition for many aspects of normal adult physiology and health. This process is disrupted by poor maternal nutrition status during pregnancy. Indeed, physiological adaptations occur in the fetus to ensure nutrient supply to the most vital organs at the expense of the others, leading to irreversible consequences in tissue formation and differentiation. Evidence indicates that maternal undernutrition in early life promotes changes in key hormones, such as glucocorticoids, growth hormones, insulin-like growth factors, estrogens and androgens, during fetal development...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29582716/amygdala-and-serum-neurotrophic-factor-levels-depend-on-rearing-condition-in-male-rats
#17
S Babri, G Mohaddes, B Mosaferi
Early life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala - and serum - BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29562949/the-developing-gut-microbiota-and-its-consequences-for-health
#18
M-J Butel, A-J Waligora-Dupriet, S Wydau-Dematteis
The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life...
March 22, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29559019/taro-flour-colocasia-esculenta-increases-testosterone-levels-and-gametogenic-epithelium-of-wistar-rats
#19
G G Ribeiro, L R Pessôa, M D C de Abreu, L B N S Corrêa, A D'Avila Pereira, M A Chagas, F Z Brandão, C A S da Costa, G T Boaventura
This study evaluated the effects of diet containing taro flour on hormone levels and the seminiferous tubules morphology of rats. After weaning, the male rats were divided into two groups (n=12 each): control group (CG) treated with control diet and taro group (TG), fed with 25% taro flour for 90 days. Food, caloric intake, mass and body length were evaluated at experiment end. Testis followed the standard histological processing. Immunostaining was performed using an anti-vimentin antibody to identify Sertoli cells...
March 21, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29534776/meconium-proteins-as-a-source-of-biomarkers-for-the-assessment-of-the-intrauterine-environment-of-the-fetus
#20
B Lisowska-Myjak, E Skarżyńska, M Bakun
Intrauterine environmental factors can be associated with perinatal complications and long-term health outcomes although the underlying mechanisms remain poorly defined. Meconium formed exclusively in utero and passed naturally by a neonate may contain proteins which characterise the intrauterine environment. The aim of the study was proteomic analysis of the composition of meconium proteins and their classification by biological function. Proteomic techniques combining isoelectrofocussing fractionation and LC-MS/MS analysis were used to study the protein composition of a meconium sample obtained by pooling 50 serial meconium portions from 10 healthy full-term neonates...
March 14, 2018: Journal of Developmental Origins of Health and Disease
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