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Case Reports in Dermatology

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https://www.readbyqxmd.com/read/30186133/atezolizumab-induced-stevens-johnson-syndrome-in-a-patient-with-non-small-cell-lung-carcinoma
#1
Phatcharawat Chirasuthat, Pamela Chayavichitsilp
Atezolizumab is a humanized anti-PD-L1 immune checkpoint antibody that is currently used in many kinds of advanced carcinoma including metastatic non-small cell lung cancer. The cutaneous side effect profile reported only 20$ of the patients which had only mild maculopapular rash that required no treatment. There is no case report of anti-PD-L1 antibody-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) eruptions. To the best of our knowledge, there is no case report of atezolizumab-induced SJS or SJS/TEN induced by anti-PD-L1 immune checkpoint antibodies...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30186132/psoriasis-vulgaris-exacerbation-during-treatment-with-a-pd-1-checkpoint-inhibitor-case-report-and-literature-review
#2
Marlies De Bock, Eva Hulstaert, Vibeke Kruse, Lieve Brochez
Objective: The incidence of immune-related adverse events is growing as the use of checkpoint inhibitors is exponentially increasing. Cutaneous adverse events are among the most frequent immune-related adverse events. The purpose of this case report and literature review is to highlight psoriasis as a potential adverse event with need for early recognition. Case Report and Literature Review: We describe the case of a 65-year-old woman with psoriasis exacerbation while treated with nivolumab (anti-PD-1) for a stage IV melanoma...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30140208/low-back-pain-in-hidradenitis-suppurativa-a-diagnosis-not-to-miss
#3
Benjamin Schnebert, Véronique Del Marmol, Farida Benhadou
We report the case of a patient suffering from hidradenitis suppurativa since puberty and complaining of chronic low back pain associated to altered sensitivity and muscular weakness in the right leg. A diagnosis of lumbosciatica was confirmed. Symptoms were not relieved after the use of nonsteroidal anti-inflammatory drugs and analgesics. A surgical decompression was then indicated but heavily debated. Indeed, extended inflammatory and fibrotic hidradenitis suppurativa lesions were located regarding the skin area eligible for the proposed surgery...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30057534/aplasia-cutis-congenita-a-case-report
#4
Tahani Magliah, Faiza Alghamdi
Background: Aplasia cutis congenita is characterized by congenital focal absence of skin in a newborn. Case Report: A 45-day-old boy presented to the outpatient clinic of dermatology at King Abdul Aziz Medical City, Jeddah, Saudi Arabia, with a flat scalp lesion on the space of the anterior fontanel. There was a positive family history of such condition in his older brother's scalp, which resolved spontaneously within 3 weeks after labor, without any medical intervention...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30057533/churg-strauss-syndrome-or-eosinophilic-granulomatosis-with-polyangiitis-exuberant-classic-clinical-picture-of-a-rare-disease
#5
Luana Vieira Mukamal, Celso Tavares Sodré, Lara Beatriz Prata, Fernanda Nakasato, Tullia Cuzzi, Marcia Ramos-E-Silva
The authors present a classic case of Churg-Strauss syndrome with an exuberant clinical picture in a 34-year-old woman. She showed the following diagnostic criteria: asthma, polyneuropathy, rhinopathy, marked eosinophilia, positive p-ANCA with a perinuclear pattern, and skin histopathology results suggestive of vasculitis with eosinophils. There was a good response to prednisone, dexamethasone pulse therapy, and cyclophosphamide.
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30022937/widely-spread-unilateral-inflammatory-linear-verrucous-epidermal-nevus-ilven
#6
Kayo Tanita, Taku Fujimura, Yota Sato, Chunbing Lyu, Setsuya Aiba
Inflammatory linear verrucous epidermal nevus (ILVEN) is an epidermal nevus that clinically and histologically mimics linear psoriasis. The pathogenesis of psoriasis has been widely investigated, with recent studies focusing especially on targeting proinflammatory cytokines such as IL-17A, TNFα, IL-23, and IL-12, while little is known about ILVEN. Since the treatment for ILVEN varies widely from the administration of topical ointment for psoriasis to invasive methods such as carbon dioxide gas laser, the differential diagnosis between ILVEN and psoriasis is necessary...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30022936/pseudolymphomatous-reaction-to-red-tattoo-pigment
#7
Ieva Saulite, Agnes Pekar-Lukacs, Katrin Kerl, Antonio Cozzio, Wolfram Hoetzenecker, Emmanuella Guenova
Decorative tattooing is a procedure in which exogenous pigment and/or dye is introduced into the dermis with the aim of creating a permanent skin decoration. The increasing prevalence of tattooed individuals leads to more reported tattoo-related complications. Pseudolymphomatous reaction is a benign reactive proliferation of lymphocytes that may uncommonly occur secondary to tattooing. We describe the clinical, histological, and molecular aspects of a pseudolymphomatous reaction to red tattoo pigment.
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30022935/a-case-of-annular-elastolytic-giant-cell-granuloma-associated-with-syphilis
#8
Xiaoping Liu, Wei Zhang, Yeqiang Liu, Mingyuan Xu
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. We report a case of 55-year-old man with AEGCG in association with syphilis, whose condition improved when hydroxychloroquine sulfate and topical tacrolimus were administered over a 2-month period...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/30022934/bullous-pemphigoid-as-an-adverse-reaction-to-pembrolizumab-two-case-reports
#9
Kenneth Thomsen, Jon Diernaes, Trine Heide Øllegaard, Eva Spaun, Christian Vestergaard
Checkpoint inhibitors are novel and promising treatment options for different types of cancer. Programmed cell death 1 (PD-1) inhibitors, such as pembrolizumab, have been shown to significantly raise the survival rates of disseminated malignant melanoma (MM). Autoimmune adverse reactions are very common in checkpoint inhibitors. We present 2 cases of bullous pemphigoid, as adverse reactions to pembrolizumab-treated MM.
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928205/methotrexate-associated-lymphoproliferative-disorder-dermoscopic-features
#10
Takeshi Namiki, Yumiko Sone, Keiko Miura, Masaru Tanaka, Hiroo Yokozeki
Methotrexate-related lymphoproliferative disorder (MTX-LPD) is a rare disorder caused by long-term MTX therapy for autoimmune diseases. There has been no report of the dermoscopic features of MTX-LPD to date. A 64-year-old female presented with a slightly elevated indurated erythematous plaque with scales on her right thigh. The patient had been treated for rheumatic arthritis with MTX and prednisolone for more than 15 years, and 18 mg/week MTX without prednisolone had been administered in the last year. Dermoscopy revealed dotted vessels and glomerular vessels on pink homogeneous areas and multiple surface scales...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928204/bullous-pemphigoid-associated-with-adalimumab-therapy-in-a-patient-with-ulcerative-colitis
#11
Sebastian Hoffmann, Mark Berneburg, Stephan Schreml
Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Other autoimmune diseases, such as lupus erythematosus, are also known to occur under TNF inhibition. Here, we report on an 81-year-old patient who received adalimumab for ulcerative colitis and subsequently developed BP. Other causes of BP (tumors, other drugs, viral or toxoplasma infections) were excluded...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928203/nevus-lipomatosis-cutaneous-superficialis-a-single-center-case-series-of-5-patients
#12
Homaid Alotaibi, Fahad Alsaif, Azhar Alali, Mohammed Almashali, Dana Al-Dabeeb, Abdul-Aziz Altaweel
Background: Nevus lipomatosis cutaneous superficialis (NLCS) is a rare hamartoma of mature adipose tissue characterized by solitary or multiple, soft, skin-colored or yellowish lobules that may coalesce to give rise to plaques with a cerebriform surface. There are two clinical types: (1) multiple lesions that are usually presented in a segmental distribution and (2) a solitary papule or nodule. Aim and Objective: To study the clinical and histopathological features of 5 Saudi patients with NLCS...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928202/basal-cell-carcinoma-mimicking-desmoplastic-trichoepithelioma-a-case-with-correlation-of-dermoscopy-and-histology
#13
Michael Kunz, Katrin Kerl, Ralph Peter Braun
Basal cell carcinoma (BCC) is the most common cancer in humans worldwide. Many highly specific dermoscopic criteria for BCC are well established in the literature. On the contrary, other malignant or benign skin tumors may mimic BCC by exhibiting similar or even the same dermoscopic features and therefore obscuring the diagnosis of BCC in certain situations. We herein report a case of BCC with dermoscopic features of both BCC and desmoplastic trichoepithelioma (DT). We would like to remind of the often neglected differential diagnosis of DT in a lesion with arborizing vessels and otherwise unusual dermoscopic presentation...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928201/efficacy-and-tolerability-of-topical-green-tea-extract-polyphenon-e-application-in-a-therapy-resistant-plantar-wart
#14
Giancarlo Meloni, Massimo Milani
Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928200/chronic-prurigo-an-unusual-presentation-of-hodgkin-lymphoma
#15
Shireen Dumont, Marc Péchère, Laurence Toutous Trellu
Background: Prurigo nodularis is a condition of unknown origin defined by papulonodular eruption and intense pruritus. Hodgkin lymphoma often presents nonspecific initial symptoms. An association between systemic malignancy and cutaneous manifestations has long been documented. We report a case of prurigo nodularis as a first presentation of Hodgkin lymphoma. Case: A 35-year-old woman presented with a 2-year history of pruritus. Previously diagnosed with bedbugs, the pruritus persisted even after insect eradication, with the appearance of papulonodular lesions consistent with chronic prurigo...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29928199/porphyria-cutanea-tarda-presenting-with-scleroderma-ichthyosis-alopecia-and-vitiligo
#16
Megan E MacGillivray, Thomas G Salopek
Porphyria cutanea tarda (PCT) is a cutaneous porphyria that presents later in life with cutaneous findings in sun-exposed sites. We report a complex case of PCT in a 67-year-old woman with an unusual constellation of cutaneous findings: scleroderma, acquired ichthyosis, and nonscarring alopecia. Possible triggers for her PCT include tamoxifen treatment for breast cancer and carrier status of the hemochromatosis gene. High-dose chloroquine was used to successfully achieve clinical remission and normalize her uroporphyrins...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29867431/anti-mda5-antibody-positive-dermatomyositis-presenting-with-cellulitis-like-erythema-on-the-mandible-as-an-initial-symptom
#17
Yuki Hattori, Kanako Matsuyama, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Mariko Seishima
Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. The patient developed typical skin eruptions of DM/CADM, rapidly progressive interstitial lung disease, and severe muscle weakness 2 weeks after the first visit...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29867430/unilateral-focal-dermal-hypoplasia-goltz-syndrome-case-report-and-literature-review
#18
Sahar Alsharif, Sohad Hindi, Fay Khoja
Focal dermal hypoplasia (FDH) or Goltz syndrome is a rare X-linked dominant multisystemic disease involving the ectoderm, mesoderm, and endoderm. About 95% of the cases appear de novo, and 90% of them are females. Recently, the studies revealed that FDH is caused by a mutation in the PORCN gene. We report a case of unilateral FDH or Goltz syndrome in a 16-year-old girl presenting with hypopigmented-reticulated atrophic macules and patches in a linear pattern distributed along the lines of Blaschko over the right side of the face and the right arm...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29867429/successful-treatment-of-pityriasis-rubra-pilaris-with-ixekizumab
#19
Kathrin Hanfstingl, Agnes Pekar-Lukacs, Reinhard Motz, Emmanuella Guenova, Wolfram Hoetzenecker
Pityriasis rubra pilaris is an inflammatory dermatologic disorder of unknown cause and often confounded with psoriasis. It is characterised by hyperkeratotic follicular papules, scaly erythematous plaques, palmoplantar keratoderma, and a progression to generalised erythroderma. Here, we report the case of a 68-year-old man with pityriasis rubra pilaris, who was successfully treated with ixekizumab, an interleukin-17A inhibitor.
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29805370/juvenile-localized-scleroderma-with-hyaline-deposits-in-the-renal-arteriole
#20
Nobuko Tabata, Chiyoko Nagano Inoue
We report a 10-year-old boy with localized scleroderma of the linear and plaque type, who showed proteinuria and hematuria. In this patient, skin, articular, and renal manifestations appeared successively and then began to resolve in the same order. A renal biopsy specimen demonstrated mild mesangial cell proliferation, exudate of immunoglobulin in the glomerular capillary, and large electron-dense deposits in the afferent arteriole. We consider that there were some transient factors that had caused the skin and articular manifestations, which also induced renal vascular inflammatory responses...
January 2018: Case Reports in Dermatology
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