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Case Reports in Dermatology

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https://www.readbyqxmd.com/read/29681811/a-case-of-ceftriaxone-induced-acute-generalized-exanthematous-pustulosis-generalized-pustular-psoriasis-overlap
#1
Jianfeng Zheng, Yunlu Gao, Xuemei Yi, Yangfeng Ding
Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this report the authors have reported a 40-year-old male patient with primary syphilis who developed generalized pustular dermatosis after the use of ceftriaxone...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29681810/incidental-squamous-cell-carcinoma-in-an-epidermal-inclusion-cyst-a-case-report-and-review-of-the-literature
#2
Ethan Frank, David Macias, Brian Hondorp, Justin Kerstetter, Jared C Inman
Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29606946/the-importance-of-excluding-cutaneous-t-cell-lymphomas-in-patients-with-a-working-diagnosis-of-papuloerythroderma-of-ofuji-a-case-series
#3
Anthony M Maher, Chloé E Ward, Steven Glassman, Ivan V Litvinov
Papuloerythroderma of Ofuji (PEO) is an erythroderma-like eruption with flat-topped papules that spare the skin folds (a "deck-chair sign" finding). Many infections, medications, and systemic diseases have been associated with PEO, including cutaneous T-cell lymphomas (CTCL). The relationship between the clinical presentation of PEO and CTCL remains poorly elucidated. Clinical, laboratory, and histopathological data were obtained from the Lymphoma Clinic at the Ottawa Hospital, Canada. We report 5 patients with deck-chair-sign-positive CTCL, mycosis fungoides, and Sézary syndrome variants...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29606945/a-case-of-vulvar-schwannoma-mimicking-epidermoid-cyst
#4
Jingwen Tan, Jia Chen, Lianjuan Yang
Schwannoma is a generally benign tumor of the peripheral nerve sheath arising from Schwann cells. Most schwannomas are found on the head and neck. Here, we describe a rare case of benign vulvar schwannoma located at the labium majus which was similar to an epidermoid cyst in clinical appearance.
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29606944/extensive-lepromatous-lymphadenitis-preceding-lesions-on-the-face-and-earlobes-an-unusual-presentation-of-leprosy-in-singapore
#5
Shi Yao Sam Yang, Wai Mun Sean Leong, Cruz Maria Teresa Kasunuran, Jing Xiang Huang, Sue-Ann Ju Ee Ho, Chen Wee Derrick Aw, Reshma A Merchant
Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries. In this case, the indurated lesions over the face demonstrated a preference for the outer lateral aspects over the maxillary areas, the nose bridge, and the pinna of the ears consistent with the organism's preference for cooler regions of the body...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29606943/successful-treatment-of-inflammatory-linear-verrucous-epidermal-nevus-with-concomitant-psoriasis-using-etanercept
#6
Reda Hesham Saifaldeen, Mohammad I Fatani, Badee Baltow, Abdulmajeed S Khan
Linear psoriasis is a rare form of the disease characterized by the linear distribution of lesions involving dermatome or along Blaschko's lines. Clinically, it may resemble inflammatory linear verrucous epidermal nevus; a combination of history, skin examination, and histopathology are required to ensure correct diagnosis and appropriate therapy. This paper describes a case of a 23-year-old male presenting with unilateral erythematous scaly plaques arranged in a linear path on the left leg. Etanercept was initiated after poor response to adalimumab...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515391/giant-congenital-melanocytic-nevi-an-update-and-emerging-therapies
#7
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515390/non-melanoma-skin-cancers-at-sites-of-previous-frostbite-case-report-and-review
#8
Khalel Imanbayev, Abay Makishev, Murat Zhagiparov, Pauline McLoone
The association between ultraviolet radiation exposure and skin cancer is well established. Limited studies have reported an association between frostbite and the development of non-melanoma skin cancer but evidence for a proven link is insufficient and possible carcinogenic mechanisms have not been fully explored. In this report, 3 cases of non-melanoma skin cancer (1 case of basal cell carcinoma and 2 cases of squamous cell carcinoma of the skin) which developed at a site of previous frostbite caused by exposure to extremely cold temperatures in Astana, the capital city of Kazakhstan, are described...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515389/sarcomatoid-tumor-following-radium-treatment
#9
Wahida Chakari, Anette Pedersen Pilt, Jørgen Lock-Andersen
Haemangiomas are benign skin lesions that usually regress spontaneously, but radiotherapy has previously been used to assist the regression and healing of the lesions. Radium and X-rays were used as a treatment for benign skin lesions such as haemangioma until the carcinogenic effect of ionising radiation in humans was described. We report a patient diagnosed with a sarcomatoid carcinoma. Her past history was of particular interest since she had received radium treatment for a haemangioma at the same location more than 70 years before...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515388/acute-erythroderma-in-a-patient-receiving-tnf-%C3%AE-blocking-therapy-for-hidradenitis-suppurativa
#10
Farida Benhadou, Guillaume Hellgren, Fabienne Willaert, Véronique Del Marmol
Tumor necrosis factor-α (TNF-α) normally binds to TNF-α receptors, leading to the inflammatory response of autoimmune diseases. Adalimumab is a TNF-inhibiting, anti-inflammatory, biological medication which binds to TNF-α, thus reducing this inflammatory response. The use of TNF-α-inhibiting medication, such as adalimumab, being the first FDA-approved treatment for hidradenitis suppurativa, has drastically changed the management of dermatological diseases. One rarely reported manifestation that occurs as a side effect associated with the use of TNF-α-blocking agents is erythroderma...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515387/a-case-of-erythema-multiforme-major-developed-after-sequential-use-of-two-immune-checkpoint-inhibitors-nivolumab-and-ipilimumab-for-advanced-melanoma-possible-implication-of-synergistic-and-or-complementary-immunomodulatory-effects
#11
Akira Utsunomiya, Noritaka Oyama, Shiro Iino, Natsuki Baba, Takenao Chino, Natsuko Utsunomiya, Minoru Hasegawa
Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance and enhance T-cell responses. Currently, ipilimumab and nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade and manageable, although all-grade rash may occur in approximately 45% of all patients. We here report the case of a young woman with erythema multiforme major, which developed after sequential use of these 2 immune checkpoint inhibitors for advanced melanoma of the scalp...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515393/incidental-treatment-of-a-subclinical-chronic-tension-type-headache-by-cosmetic-use-of-botulinum-toxin-a-a-case-report
#12
Iselin Saltvig, Steen Henrik Matzen
Background: Headache is a common disorder of the nervous system; chronic headache in particular may affect quality of life negatively. The pathophysiology is multifactorial and not completely elucidated. Studies have demonstrated the beneficial effects of botulinum toxin A on chronic migraine headaches, but failed to show the same effect on chronic tension-type headaches. Methods: We present the case of a 32-year-old woman who after receiving cosmetic injections with botulinum toxin A for fine lines of the forehead experienced relief of subclinical tension-type headaches...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29515392/large-cell-transformed-mycosis-fungoides-coexisting-with-mycosis-fungoides-bullosa-a-case-report-and-review-of-the-literature
#13
Saneerat Porntharukcharoen, Suthinee Rutnin, Natta Rajatanavin
Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. Both large-cell transformed mycosis fungoides and mycosis fungoides bullosa are rare presentations and predict unfavorable prognosis. We report the case of a 61-year-old woman who presented with generalized erythematous scaly annular plaques, and histopathology confirmed the diagnosis of mycosis fungoides. She was treated with various conventional therapies but only achieved partial response and always relapsed after discontinuation of treatment...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29422844/acrodermatitis-continua-of-hallopeau-with-bone-resorption-in-an-8-year-old-patient-a-case-report
#14
May Alorainy, Mohammed Alshaya, Ammar Al-Rikabi, Mohammed Ayesh, Fahad Alsaif
Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. While the incidence of ACH is rare in children, complications like osteolysis have not been reported previously in this age group. In this paper, we report the case of an 8-year-old boy with severe ACH complicated by bone resorption...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29422843/cutaneous-metastases-from-salivary-duct-carcinoma-of-the-submandibular-gland
#15
Wahida Chakari, Luise Andersen, Jørgen Lock Andersen
Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. To the best of our knowledge, this is the first reported case of salivary duct carcinoma arising from the submandibular gland with cutaneous metastases...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282398/fenofibrate-induced-lichenoid-drug-eruption-a-rare-culprit
#16
Fayeza Mohammed, Laura L Wally, Jeffrey E Karaban, Vijaya B Reddy, Yongsuk Lertratanakul
A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. In addition, we report a potential familial association which underscores the potential for underlying genetic mechanisms to be contributory to lichenoid drug eruptions. A reminder of the physical characteristics of lichen planus, knowledge of the temporal relation between administration of medications and a lichenoid drug eruption, recognition of the effect of UV exposure on lichenoid drug eruptions, and realization for the potential of symptoms to persist despite discontinuation of an offending agent can aid practitioners in promptly diagnosing lichenoid drug eruptions and initiating appropriate therapy...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282397/swan-neck-deformity-mimicking-claw-hand-caused-by-arthritis-in-leprosy
#17
Hendra Gunawan, Nia Srie Haryati, Oki Suwarsa
Swan neck deformity is a hyperextension of the proximal interphalangeal (PIP) joints and flexion of the distal interphalangeal (DIP) joints. Claw hand is a hyperextension of the metacarpal joints and flexion of the PIP joints, accompanied by reduced motor strength. A 23-year-old female, who was released from leprosy treatment, presented with a bend of the second to fifth fingers of both hands. There was hyperextension of the PIP joints and flexion of the DIP joints from the second to fifth fingers of both hands, thickening of the ulnar nerves, and hypoesthesia without motor impairment of the fourth and fifth fingers of both hands...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282396/carcinoma-cuniculatum-of-the-right-thenar-region-with-bone-involvement-and-lymph-node-metastases
#18
Robert Feldmann, Marlies Wruhs, Tobias Peinhaupt, Alexander Stella, Friedrich Breier, Andreas Steiner
Squamous cell carcinoma (SCC) is the second most common type of skin cancer after basal cell carcinoma (BCC). The overall prevalence of BCC is 3 times higher than that of SCC, but this can vary when looking at specific locations such as the hand, where SCC is much more common than BCC. Carcinoma (or epithelioma) cuniculatum is a rare variant of SCC. It was originally described as a verrucous carcinoma of the soles. Exceptionally, it can arise in other parts of the skin. We report a rare case of carcinoma cuniculatum of the right thenar region with bone and lymph node involvement...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282395/lichen-planus-pemphigoides-induced-by-enalapril-a-case-report-and-a-review-of-literature
#19
Woranit Onprasert, Kumutnart Chanprapaph
Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old Thai woman with underlying hypertension and type 2 diabetes mellitus who presented with a 4-week history of multiple tense bullae initially on the hands and feet that subsequently expanded to the trunk and face...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29282394/treatment-of-multiple-actinic-keratosis-and-field-of-cancerization-with-topical-piroxicam-0-8-and-sunscreen-50-in-organ-transplant-recipients-a-series-of-10-cases
#20
Virginia Garofalo, Alessandra Ventura, Sara Mazzilli, Laura Diluvio, Luca Bianchi, Luca Toti, Giuseppe Tisone, Massimo Milani, Elena Campione
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers...
September 2017: Case Reports in Dermatology
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