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Case Reports in Oncology

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https://www.readbyqxmd.com/read/30323753/sarcomatoid-variant-of-bladder-carcinoma-a-case-report
#1
Koichi Uemura, Takashi Kawahara, Hiroaki Ishida, Noboru Nakaigawa, Mikiko Tanabe, Masahiro Yao, Hiroji Uemura
A 59-year-old man was referred to our hospital complaining of asymptomatic gross hematuria. Cystoscopy revealed a papillary tumor 8 cm in diameter filling the bladder. The patient underwent transurethral resection of the bladder tumor. The pathological findings revealed the sarcomatoid variant of urothelial carcinoma with a heterologous osteosarcomatous element. He had no metastasis according to our imaging analyses; thus, we planned radical cystectomy after two courses of neoadjuvant chemotherapy (gemcitabine and cisplatin)...
September 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30323752/rechallenge-with-first-line-platinum-chemotherapy-for-sensitive-relapsed-small-cell-lung-cancer
#2
Toshihiro Shiozawa, Ikuo Sekine, Yuka Aida, Hiroko Watanabe, Kensuke Nakazawa, Koichi Kurishima, Hiroaki Satoh, Nobuyuki Hizawa
Background: Sensitive-relapsed small-cell lung cancer (SCLC) is thought to be sensitive to chemotherapy; therefore, second-line chemotherapy is recommended. Although platinum rechallenge is performed in the second-line chemotherapy for sensitive-relapsed SCLC, it remains unclear whether such a strategy is effective. Methods: We retrospectively analyzed the outcome of rechallenge chemotherapy for sensitive-relapsed SCLC. The endpoints of this study were progression-free survival from the time of relapse (PFS-Re) and overall survival from the time of relapse (OS-Re)...
September 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30323751/nivolumab-induced-impressive-response-of-refractory-pulmonary-sarcomatoid-carcinoma-with-brain-metastasis
#3
Massimiliano Salati, Cinzia Baldessari, Fiorella Calabrese, Giulio Rossi, Elisa Pettorelli, Giulia Grizzi, Massimo Dominici, Fausto Barbieri
Background: Pulmonary sarcomatoid carcinoma is a rare, poorly differentiated, and highly aggressive type of non-small cell lung cancer. High tumor mutational burden and PD-L1 overexpression make it an excellent candidate for immunotherapy. Objectives and Method: We presented the case of a patient who underwent left inferior lobectomy with concurrent right paravertebral muscular metastasectomy for an infiltrative neoplastic mass, whose final diagnosis was consistent with stage IV pulmonary sarcomatoid carcinoma...
September 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30323750/bowen-s-disease-of-the-nipple
#4
Miyuki Kitahara, Yasuo Hozumi, Akie Watanabe, Tatsuo Iijima
Bowen's disease is a type of intraepidermal squamous cell carcinoma that commonly develops in areas of the skin exposed to sunlight, such as the scalp, trunk, and limbs. Although development of Bowen's disease in other sites, such as the nipple, is extremely rare, we herein report our experience with one such case. A 76-year-old female presented to our hospital with complaints of right nipple pruritus. We diagnosed Bowen's disease via nipple skin biopsy, and the patient underwent right nipple resection. The deep tissue margin was positive for malignancy; therefore, the patient subsequently underwent right partial mastectomy...
September 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30283317/two-cases-of-long-term-survival-of-advanced-colorectal-cancer-with-synchronous-lung-metastases-treated-with-mfolfox6-xelox-bevacizumab
#5
Yuta Ushida, Eiji Shinozaki, Keisho Chin, Mitsukuni Suenaga, Daisuke Takahari, Masato Ozaka, Mariko Ogura, Takashi Ichimura, Takeru Wakatsuki, Kensei Yamaguchi
Background: Colorectal cancer (CRC) with lung metastases has an unfavorable prognosis. However, nowadays, even advanced CRC can have a favorable outcome in certain cases. A complete response (CR) is a rare event in advanced CRC with lung metastases. Herein, we report 2 rare cases of advanced CRC attaining a CR. Case Presentation: Case 1 was a 58-year-old man who underwent laparoscopic ileocecal resection for cecum cancer with multiple metastases to the lungs in 2011...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30283316/extracranial-metastases-of-a-cerebral-glioblastoma-a-case-report-and-review-of-the-literature
#6
Jurij Rosen, Tobias Blau, Stefan J Grau, Michael T Barbe, Gereon R Fink, Norbert Galldiks
The glioblastoma, a malignant human brain tumor, is known for its devastating intracranial progress and its dismal prognosis. Whereas treatment and research are most prominently focused on the primary tumor lesion, in recent years evidence has accumulated that points to the rare occurrence of extracranial glioblastoma metastases. We here present a case of a female patient with a known glioblastoma who was detected to harbor multiple metastases in the bones, lung, pleura, liver, mesentery, and the subcutaneous soft tissue...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30283315/hydrogen-sulfide-and-hydrogen-sulfide-synthesizing-enzymes-are-altered-in-a-case-of-oral-adenoid-cystic-carcinoma
#7
Kim Dongsoo, Jie Chen, Eric Wei, Junaid Ansari, Andrew Meram, Stavan Patel, Ghali Ghali, Christopher Kevil, Rodney E Shackelford
Adenoid cystic carcinomas (ACC) constitute 1% of all head and neck malignancies and are very rare in the oral cavity. With < 60 oral ACCs described, their pathobiology is incompletely understood. Here, we report a case of oral cavity ACC in a 54-year-old woman. Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2 S)-synthesizing enzymes cystathionine-β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2 S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186143/accurate-detection-of-tumor-infiltration-by-11-c-methionine-positron-emission-tomography-in-a-patient-with-central-nervous-system-intravascular-lymphoma-a-case-report
#8
Shoji Yomo, Keiji Tsutsumi, Takehiro Yako, Hiromasa Sato, Takao Hashimoto, Kazuhiro Oguchi
Intravascular lymphoma (IVL) is a rare and clinically devastating subtype of extranodal diffuse large B-cell lymphoma with a distinct presentation. Diagnostic difficulty derives from marked variability in clinical presentations and nonspecific laboratory and radiological findings, especially when central nervous system (CNS) symptoms are the only manifestation. Establishing the diagnosis premortem thus remains a major challenge. We describe a 70-year-old male with CNS IVL. He presented with acute onset of neurocognitive impairments...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186142/acute-myeloid-leukemia-with-myelodysplasia-related-changes-in-a-patient-with-crohn-s-disease-treated-with-immunosuppressive-therapy
#9
Bowen Li, Zhenhua Zhu, Shunhua Long, Fei Li, Xuan Zhu, Wangdi Liao
We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn's disease. The patient was diagnosed with Crohn's disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that involved mainly erythropoiesis. Crohn's disease is associated with an increased risk of cancers including hematological malignancies...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186141/leukoerythroblastosis-with-cytopenia-as-an-initial-presentation-of-lung-adenocarcinoma
#10
Rouslan Kotchetkov, Robert El-Maraghi, Leena Narsinghani
A 74-year-old male with a history of chronic lymphocytic leukemia (CLL) previously treated with fludarabine/cyclophosphamide/rituximab (FCR) 5 years ago, presented with progressive fatigue, mucocutaneous bleeding, and cytopenias (hemoglobin 51 g/L, platelets 8.0 × 109 /L, lymphocytes 0.4 × 109 /L). He had normal respiratory findings, and no lymphadenopathy or hepatosplenomegaly. Further workup revealed a small spiculated lung nodule and multiple sclerotic bony lesions. Due to bleeding/profound thrombocytopenia, lung biopsy was not feasible...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186140/sarcoid-like-granulomatosis-induced-by-nivolumab-treatment-in-a-lung-cancer-patient
#11
Susumu Noguchi, Hiroaki Kawachi, Hiroshi Yoshida, Akari Fukao, Satoshi Terashita, Tatsuyoshi Ikeue, Sadao Horikawa, Takakazu Sugita
Nivolumab, an anti-PD-1 antibody, inhibits binding between PD-1 and PD-1 ligand and activates antigen-specific T cells that have become unresponsive to cancer cells. Although it is recommended as a second-line therapy in gene mutation-negative non-small-cell lung cancer, interstitial pneumonia is a well-known side effect of the drug; however, granulomatous lesions have rarely been reported. We describe the case of an 81-year-old male with cT1aN2M1b stage IV pleomorphic carcinoma of the left upper lobe of the lung...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186139/aromatase-inhibitor-associated-tendinopathy-and-muscle-tendon-rupture-report-of-three-cases-of-this-exceedingly-rare-adverse-event
#12
Nikolaos Mitsimponas, Evangelia Klouva, Dimitrios Tryfonopoulos, Anastasios Grivas, Stamatina Demiri, George Koumakis, Panagiotis Gouveris
Aromatase inhibitors (AIs) are a commonly used antihormonal therapy in the treatment of breast cancer in postmenopausal women, specifically in the treatment of hormone receptor-positive breast cancer. AI-associated tendinopathy and muscle tendon rupture is exceedingly rare. Until now, only one case with AI-associated severe tendinopathy has been reported in the medical literature, and there are no recorded cases of AI-associated muscle tendon rapture. We report three cases of postmenopausal women with hormone receptor-positive breast cancer, who experienced tendinopathy or muscle tendon rupture under antihormonal treatment with letrozole...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186138/severe-gastritis-after-administration-of-nivolumab-and-ipilimumab
#13
Yoshito Nishimura, Miho Yasuda, Kazuki Ocho, Masaya Iwamuro, Osamu Yamasaki, Takehiro Tanaka, Fumio Otsuka
Immune checkpoint inhibitors such as ipilimumab, a cytotoxic T-lymphocyte-associated antigen-4 inhibitor, have been widely used for advanced malignancies. As these inhibitors improve antitumor immunity via T-cell modulation, immune-mediated adverse events associated with T-cell activation, such as colitis, might occur. Herein, we describe a 75-year-old Japanese woman with metastatic malignant melanoma who developed hemorrhagic gastritis after ipilimumab treatment. There was no macroscopic or clinical improvement of gastritis after proton pump inhibitor treatment...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186137/searching-for-the-culprit-metastases-from-a-cancer-of-unknown-primary
#14
Rita Dorantes-Heredia, Daniel Motola-Kuba, Jose Manuel Ruiz-Morales, Wallace Rafael A Muñoz-Castañeda, Carolina Vega-Ochoa, Roberto De la Peña
We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and axillary adenopathy on the left side...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186136/a-case-of-vanishing-metastatic-mass-right-atrial-mass-in-the-setting-of-primary-epithelioid-hemangioendothelioma-of-the-spine
#15
Eshan Patel, P Kancharla, B K Surapaneni, K Hennrick, M Goldfinger, M Kalavar
Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186135/ado-trastuzumab-emtansine-induced-pulmonary-toxicity-a-single-institution-retrospective-review
#16
Heidi Egloff, Kelley M Kidwell, Anne Schott
Purpose: T-DM1 is an antibody drug conjugate with proven efficacy in metastatic breast cancer for progressive disease refractory to trastuzumab. Drug-induced pneumonitis is a rare serious potential adverse effect. The purpose of this review was to estimate the incidence of pulmonary toxicity at our institution. Methods: A retrospective analysis of electronic medical record data inclusive of all women and men aged 18 years and older treated with T-DM1 at out institution was undertaken...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30186134/neurosarcoidosis-following-immune-checkpoint-inhibition
#17
Anastasie M Dunn-Pirio, Suma Shah, Christopher Eckstein
Recently, immune checkpoint inhibitors have revolutionized cancer care by enhancing anti-tumor immunity. However, by virtue of stimulating the immune system, they can lead to immune-related adverse events (irAEs). Neurologic irAEs are uncommon but are becoming increasingly recognized and can be quite serious or even fatal. Furthermore, central nervous system (CNS) manifestations may be difficult to distinguish from CNS metastases, posing management challenges. Here, we describe a patient who developed exacerbation of sarcoidosis leading to CNS involvement following dual checkpoint blockade with nivolumab and ipilimumab for metastatic melanoma and review the relevant literature...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30140215/overcoming-the-adverse-effects-of-everolimus-to-achieve-maximum-efficacy-in-the-treatment-of-inoperable-breast-cancer-a-review-of-11-cases-at-our-hospital
#18
Yuko Yoshida-Ichikawa, Masahiko Tanabe, Emi Tokuda, Hideo Shimizu, Yoshiya Horimoto, Kayo Miura, Mitsue Saito
Everolimus is an effective treatment for advanced and/or metastatic breast cancer, especially in hormone receptor-positive cases. However, adverse events have prevented considerable numbers of clinicians from using this drug. Herein, we reviewed our clinical experiences and endeavored to identify patients in whom the benefits of everolimus treatment would outweigh these adverse events. If measures were available to prevent or minimize adverse effects prior to treatment, everolimus would be a more widely applicable drug...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30140214/primary-diffuse-b-cell-thyroid-lymphoma-case-report-and-literature-review
#19
Hassan Alyami, Talal Alsofyani, Mohammed Bu Bshait, Emad Mohammed Al-Osail
Background: Primary thyroid lymphoma (PTL) is a rare disease, accounting for 5% of all thyroid malignancies. Diffuse B-cell lymphoma (DBCL) is the most common type of PTL. The diagnosis of PTL depends on biopsy results, and its management depends on the histological type. Case Presentation: A 66-year-old female complained of a huge neck mass on the right side that had started growing 3 months previously and was associated with compressive and B symptoms. She had undergone left hemithyroidectomy 20 years previously...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30140213/neoadjuvant-trabectedin-plus-radiotherapy-in-high-grade-sarcoma-of-the-leg-a-case-report
#20
António José Loureiro da Silva, Carolina Carvalho, Miguel Jacobetty, João Freitas, Ruben Fonseca, Paulo F Tavares, Helena Garcia, Margarida Borrego, José M Casanova
Here, we present the case of a 78-year-old male patient with undifferentiated spindle cell sarcoma on the posteromedial surface of the right leg who experienced a long-lasting progression-free survival. Due to an underlying cardiac disease, the patient was not suitable for anthracyclines. In September 2015, he received first-line chemotherapy with trabectedin (Yondelis®) at the approved dosage and regimen - concomitant with external radiotherapy (RT). After the first 9 cycles of trabectedin plus RT given in the neoadjuvant setting, the patient underwent surgical resection...
May 2018: Case Reports in Oncology
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