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Case Reports in Oncology

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https://www.readbyqxmd.com/read/27790122/achievement-of-cure-with-gefitinib-in-advanced-lung-adenocarcinoma-harboring-an-activating-egfr-mutation-a-case-report
#1
Taiji Kuwata, Kazue Yoneda, Kenichi Kobayashi, Rintarou Oyama, Hiroki Matumiya, Shuichi Shinohara, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
Tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) may achieve long-term survival in selected cases with advanced non-small cell lung cancer harboring activating mutations in the EGFR gene, but a cured case has not been reported yet. Here, we present the first case of EGFR-mutated lung adenocarcinoma cured with an EGFR-TKI, as the 75-year-old Japanese man has achieved complete response with gefitinib treatment and has survived without tumor 10 years after termination of gefitinib treatment...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790121/long-term-survival-after-resection-of-lung-metastases-from-hepatocellular-cancer-report-of-a-case-and-review-of-the-literature
#2
Sneha Chelimeda, Teresa Bejarano, Robert Lowe, Mahmoud Soliman, Qing Zhao, Kevan L Hartshorn
Hepatocellular cancer (HCC) is increasing dramatically in incidence in Europe and the United States due mainly to the hepatitis C epidemic and, to a lesser extent, increased body mass index of the population. In the fairly recent past, HCC was largely considered as untreatable due to detection mainly at late stages and lack of effective drugs for treatment. Several advances have led to changes in the prognosis of HCC. Screening of high-risk populations has allowed for earlier detection in some studies. If found at an early stage, liver transplantation not only cures the usual underlying cirrhosis but has cure rates for HCC in the range of 60% in recent series...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790120/inflammatory-myofibroblastic-tumor-in-the-bladder-a-case-report
#3
Takuya Kondo, Takashi Kawahara, Sawako Chiba, Mari Ohtaka, Yohei Kumano, Yoko Saitoh, Taku Mochizuki, Yusuke Hattori, Jun-Ichi Teranishi, Yasuhide Miyoshi, Yasushi Yumura, Masahiro Yao, Yoshiaki Inayama, Hiroji Uemura
A 36-year-old male was referred to our department for further examination of asymptomatic gross hematuria emanating from a bladder tumor. Cystoscopy revealed a broad-based tumor 40 mm in diameter. Urinary cytology was negative. Preoperative magnetic resonance imaging suggested a muscle invasive tumor. Transurethral resection was performed, and the pathological findings revealed an inflammatory myofibroblastic tumor. We herein report a rare case of bladder inflammatory myofibroblastic tumor.
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790119/paraneoplastic-dermatomyositis-in-hepatocellular-carcinoma-with-colonic-perforation-a-case-report
#4
Naoteru Miyata, Katsura Emoto, Yoshiaki Dei, Kazuhiro Tomiyasu, Ryoko Ishiyama, Tomofumi Horie, Gen Sakai, Toshiyuki Tahara
BACKGROUND: Dermatomyositis (DM) is an autoimmune disease characterized by cutaneous Gottron papules, heliotrope rash, and proximal myopathy. It may also present as a paraneoplastic syndrome that can complicate a variety of different cancers, such as lung, cervical, and breast cancer. However, the association with hepatocellular carcinoma (HCC) is extremely rare. Moreover, to our knowledge, there are no previous reports of colonic perforation following steroid pulse treatment for a DM patient...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790118/two-case-reports-of-rare-braf-mutations-in-exon-11-and-exon-15-with-discussion-of-potential-treatment-options
#5
Georg Richtig, Ariane Aigelsreiter, Karl Kashofer, Emina Talakic, Romana Kupsa, Helmut Schaider, Erika Richtig
BRAF mutations occur in up to 50% of melanomas. Mutations in the BRAF gene directly influence the patient's treatment because several inhibitors are available that only target BRAF(V600) mutations. Herein, we describe two cases of patients with metastatic melanomas, each carrying a 'nonstandard' mutation in the BRAF gene: BRAF(K601E) and BRAF(G466E), respectively. The first patient was treated with a MEK inhibitor and the second one with ipilimumab. However, not all BRAF mutations result in increased BRAF kinase activity, and clinical data for 'nonstandard' mutations, such as those described in our case report, are sparse...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790117/rapid-response-to-high-dose-pulsatile-erlotinib-in-afatinib-refractory-leptomeningeal-carcinomatosis-from-adenocarcinoma-of-the-lung-a-case-report
#6
Frank S Fan
Leptomeningeal carcinomatosis occurred in an old female patient who was on a standard dose of afatinib for the treatment of her non-small cell lung cancer harboring an epidermal growth factor receptor gene mutation sensitive to tyrosine kinase inhibitors when extracranial lesions were still under control. Shifting to high-dose, pulsatile erlotinib dramatically saved her from the devastating condition in a very short period of time. Inadequate afatinib concentration in cerebrospinal fluid is reasonably suspected, and there is a call for clinical trials testing high-dose afatinib in leptomeningeal carcinomatosis...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790116/bilateral-choroidal-metastases-from-lung-adenocarcinoma-a-case-report
#7
Hasan Ergenc, Attila Onmez, Ezgi Oymak, Ramiser Tanriseven, Erkan Celik, Funda Ebru Onmez, Ali Tamer, Meltem Baykara
The most common malignancy of the eye is metastatic tumors, with choroidal metastases being the majority of them. In women, breast cancer is the most common cause of orbital metastases, and in men, it is lung cancer. Despite the fact that there are efficient treatment options for orbital metastases, the benefit of procedures to detect choroidal metastases is debatable due to the quick progression and poor prognosis of lung cancer. In choroidal metastases resulting from lung cancer, patients are usually presented with decreased sight...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27790115/diagnosis-of-jejunal-metastases-from-lung-cancer-using-capsule-endoscopy
#8
Charlotte Leduc, Nathalie Prim, Bertrand Mennecier, Michel Delvaux, Afshin Gangi, Elisabeth Quoix
Gastrointestinal metastases from lung cancer are rare and usually asymptomatic. We report a case of small bowel metastases from primary lung cancer revealed by abdominal pain and severe recurrent anaemia. The diagnosis was obtained with capsule endoscopy. This non-invasive procedure thus represents a valuable method contributing to a rapid and detailed diagnosis while reducing underdiagnosis, and it should thus be considered for lung cancer patients complaining of abdominal symptoms, which may indeed be related to gastrointestinal metastases...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27752243/arriving-at-the-right-diagnosis-in-an-era-of-precision-medicine
#9
Vina Pulido, Shin Yin Lee, Naomi Yu Ko
In the era of precision medicine and targeted therapy, diagnostic inaccuracy can have tremendous ramifications. We present the case of a 61-year-old man initially diagnosed with small cell lung cancer by pathology. Prior to initiating chemotherapy, multidisciplinary discussions led to an amendment of the diagnosis to medullary thyroid cancer.
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721778/unresectable-recurrent-multiple-meningioma-a-case-report-with-radiological-response-to-somatostatin-analogues
#10
Ana Ortolá Buigues, Irene Crespo Hernández, Manuela Jorquera Moya, Jose Ángel Díaz Pérez
Medical treatment of meningiomas is reserved for cases in which surgery and radiotherapy have failed. Given that a high percentage of meningiomas express somatostatin receptors, treatment with somatostatin analogues has been proposed. In addition, these medications have been shown to have an antiproliferative and antiangiogenic effect in vitro. To date, very few cases with clinical response and none with radiological response have been described. The case described here is the first to report a radiological response...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721777/granulomatous-mastitis-a-rare-cause-of-male-breast-lump
#11
Abdel Rahman A Al Manasra, Mohammad F Al-Hurani
BACKGROUND: Mastitis is a common benign disorder of the female breast. It is frequently associated with tenderness, swelling and nipple discharge. We are describing an extremely rare case of an idiopathic granulomatous mastitis in the male breast. Only 1 previous case was reported. CASE REPORT: A 29-year-old male patient presented with a hard, painless lump in the right breast of 2 weeks duration. The patient underwent surgical excision with margin. The histopathologic findings were consistent with granulomatous mastitis...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721776/cabazitaxel-for-metastatic-castration-resistant-prostate-cancer-retrospective-data-analysis-from-an-indian-centre
#12
Vanita Noronha, Amit Joshi, Vamshi Krishna Muddu, Vijay Maruti Patil, Kumar Prabhash
<bold>Objective:</bold> To determine the efficacy and safety of cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC) patients from the named patient programme (NPP) at our centre. <bold>Methods:</bold> mCRPC patients who progressed on docetaxel were given cabazitaxel intravenously every 3 weeks until disease progression or unacceptable toxicity occurred. Overall survival, progression-free survival, prostate-specific antigen response, quality of life (QOL) changes, and safety were reported...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721775/intra-arterial-delivery-of-idarubicin-in-two-patients-with-glioblastoma
#13
Mohamad Chehimi, Mathieu Boone, Cyril Chivot, Hervé Deramond, Jean-Marc Constans, Mony Chenda Ly, Bruno Chauffert
There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721774/utilization-of-behavioral-medicine-services-to-refine-medical-diagnostic-formulation-in-the-face-of-uncertain-symptom-presentation
#14
David A Moore, Elisabeth S Markman, Cori E McMahon, Maurie Markman
In the ever expanding realm of cancer care, the psychosocial impact of disease and medical treatments has been garnering increased attention. To address these needs, the integration of behavioral medicine services into inpatient and outpatient medical settings has added a unique resource available to oncologists. Psycho-oncologists may assist providers via the provision of psychological assessment and intervention, supplying valuable consultation to members of the medical team and much needed clinical services to patients...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721773/pleural-nodules-and-mediastinal-lymphadenopathy-in-a-smoker-an-unusual-case-report
#15
Damien Desbuquoit, Stijn Van Hecke, Pjotr Even, Paul M Parizel, Jan P van Meerbeeck, Annemie Snoeckx
The authors report a case of thoracic splenosis, which is the autotransplantation of splenic tissue into the pleural cavity. Splenosis in the chest is a rare entity and most often an incidental finding on chest computed tomography, typically showing solitary or multiple well-defined, noncalcified pleural nodules of variable size in the left hemithorax. It is important to include this benign pathology in the differential diagnosis among other, generally malignant, pleural lesions. Imaging clues to the diagnosis are absence of the spleen and/or associated rib fractures...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721772/response-to-paclitaxel-in-an-adult-patient-with-advanced-kaposiform-hemangioendothelioma
#16
José Maurício Mota, Mariana Scaranti, Leonardo G Fonseca, Diego Araújo Tolói, Veridiana Pires de Camargo, Rodrigo Ramella Munhoz, Olavo Feher, Paulo M Hoff
BACKGROUND: Kaposiform hemangioendothelioma (KHE) is a rare neoplasm of vascular origin that typically arises from the skin or soft tissues as a solitary tumor. The optimal therapy for this disease is still unknown. We report the case of an adult patient presenting with metastatic KHE of the spleen, who had a partial response after treatment with paclitaxel. CASE PRESENTATION: A 36-year-old man presented in November 2012 with a nontraumatic rupture of the spleen...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721771/maximizing-benefits-from-maintenance-pemetrexed-with-stereotactic-ablative-radiotherapy-in-oligoprogressive-non-squamous-non-small-cell-lung-cancer
#17
Shao-Lun Lu, Feng-Ming Hsu, Kuan-Yu Chen, Chao-Chi Ho, James Chih-Hsin Yang, Jason Chia-Hsien Cheng
Maintenance pemetrexed offers survival benefit with well-tolerated toxicities for advanced non-squamous non-small cell lung cancer (NSCLC). We present 3 consecutively enrolled patients with advanced non-squamous NSCLC, receiving stereotactic ablative radiotherapy (SABR) for oligoprogressive disease during maintenance pemetrexed. All of them had sustained local control of thoracic oligoprogression after the SABR, while maintenance pemetrexed were kept for additionally long progression-free interval. SABR targeting oligoprogression with continued pemetrexed is an effective and safe approach to extend exposure of maintenance pemetrexed, thus maximizing the benefit from it...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721770/thrombotic-microangiopathy-revealing-bone-metastases-from-an-ethmoid-sinus-carcinoma
#18
Mony Chenda Morisse, Loay Kontar, Céline Bihan, Mathieu Boone, Emma Lachaier, Dimitri Titeca-Beauport, Julien Maizel, Bruno Chauffert
Cancer-related thrombotic microangiopathy (TMA) is a rare entity whose clinical and biological characteristics have been described in various tumors. Here we describe the first case of cancer-related TMA revealing diffuse bone metastases from an ethmoid sinus carcinoma.
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721769/inflammatory-myofibroblastic-tumor-of-the-urinary-bladder-a-case-report
#19
Toshiki Etani, Taku Naiki, Takashi Nagai, Keitaro Iida, Ryosuke Ando, Aya Naiki-Ito, Noriyasu Kawai, Keiichi Tozawa, Kentaro Mizuno, Atsushi Okada, Tohru Mogami, Takahiro Yasui
An inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by inflammatory infiltration of plasma cells, lymphocytes, and eosinophils. IMTs rarely occur in the urinary bladder. It is important to distinguish this tumor from other malignant spindle cell tumors. Herein, we report a patient with an IMT showing muscle invasion, who underwent a transurethral resection of the bladder tumor and, at a later date, partial cystectomy. The resected tumor specimen revealed a proliferation of spindle-shaped cells on a background of plasma cells and lymphocytes...
May 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27721768/prostate-specific-membrane-antigen-pet-ct-false-positive-results-due-to-sarcoidosis
#20
Robert M Hermann, Manoutschehr Djannatian, Norbert Czech, Mirko Nitsche
We report on a 72-year-old male patient who developed sarcoidosis of the mediastinal lymph nodes, the liver, and the prostate 11 years ago. Seven years later, he underwent transurethral resection of the prostate by laser due to hematuria. Pathology of the resected chips showed a 'granulomatous prostatitis with epitheloid cells'. Malignancy was histologically excluded at that time. Four years later, he was diagnosed with an undifferentiated prostate carcinoma, with a Gleason score of 5 + 4 = 9. After initiation of antihormonal therapy, he underwent radical prostatectomy and pelvic lymphadenectomy, which revealed a pT3b pN1 carcinoma with infiltrated resection margins...
May 2016: Case Reports in Oncology
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