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EPMA Journal

Babak Baban, Jun Yao Liu, Samuel Payne, Worku Abebe, Jack C Yu, Mahmood S Mozaffari
BACKGROUND: Recruitment of stem cells to sites of tissue injury constitutes an important mechanism aimed at tissue repair and regeneration. However, it is not clear how the diabetic milieu affects the viability of endogenous stem cells. Thus, we tested the hypothesis that diabetes mellitus is associated with increased apoptosis which, in turn, contributes to reduction in stem cells and the manifestation of type 2 diabetic nephropathy. METHODS: Sixteen-week-old male obese type 2 diabetic db/db mice, and their appropriate controls, were used for assessment of the status of endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and hematopoetic stem cells (HSCs) in the peripheral blood and renal tissue using specific cell markers...
2016: EPMA Journal
John Paul Cauchi, Liberato Camilleri, Christian Scerri
AIM AND BACKGROUND: Environmental exposures are known to play a role in the development of cancer, including breast cancer. There are known associations of breast cancer with environmental factors such as sunlight exposure, diet and exercise and alcohol consumption as well as physiological factors. This study examines the prevalence of risk factors for breast cancer related to dietary intake, environment and lifestyle in the female population of Malta. Malta has had little research in this area, and therefore an exploratory study was carried out...
2016: EPMA Journal
Vitalii Kupaev, Oleg Borisov, Ekaterina Marutina, Yu-Xiang Yan, Wei Wang
BACKGROUND: Suboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction. METHODS: A community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks...
2016: EPMA Journal
Teruyo Kida, Josef Flammer, Hidehiro Oku, Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Katarzyna Konieczka, Tsunehiko Ikeda
BACKGROUND: Branch retinal vein occlusion (BRVO) commonly occurs at the arteriovenous crossing in the unilateral eye, and cardiovascular diseases can be risk factors of BRVO. However, the pathomechanism leading to BRVO is not yet clear. In addition to mechanical compression, the vein might locally constrict due to an altered biochemical environment, such as an increase in the concentration of endothelin-1 (ET-1). We evaluated changes in ET-1 following injection of intravitreal bevacizumab (IVB), which is the anti-vascular endothelial growth factor (VEGF) agent with the longest serum half-life, to determine the effect on BRVO-related macular edema...
2016: EPMA Journal
Kneginja Richter, Jens Acker, Sophia Adam, Guenter Niklewski
BACKGROUND: Excessive fatigue and insomnia are common among shift workers and can lead to negative effects such as reduced work performance, processing errors, accidents at work, absenteeism, reduced quality of life, and symptoms of depression. Moreover, work in rotating shifts can be a risk factor for different somatic and psychiatric diseases and may contribute to poor health, especially in elder adults and women. This review aims to show non-pharmacological preventive measures against fatigue and insomnia in shift workers...
2016: EPMA Journal
Yevhen V Moiseyenko, Viktor I Sukhorukov, Georgiy Yu Pyshnov, Iryna M Mankovska, Kateryna V Rozova, Olena A Miroshnychenko, Olena E Kovalevska, Stefan-Arpad Y Madjar, Rostyslav V Bubnov, Anatoliy O Gorbach, Kostiantyn M Danylenko, Olga I Moiseyenko
[This corrects the article DOI: 10.1186/s13167-016-0060-8.].
2016: EPMA Journal
Suzanne Hagan, Eilidh Martin, Amalia Enríquez-de-Salamanca
In the field of predictive, preventive and personalised medicine, researchers are keen to identify novel and reliable ways to predict and diagnose disease, as well as to monitor patient response to therapeutic agents. In the last decade alone, the sensitivity of profiling technologies has undergone huge improvements in detection sensitivity, thus allowing quantification of minute samples, for example body fluids that were previously difficult to assay. As a consequence, there has been a huge increase in tear fluid investigation, predominantly in the field of ocular surface disease...
2016: EPMA Journal
Jiri Polivka, Jiri Polivka, Kristyna Krakorova, Marek Peterka, Ondrej Topolcan
Neurology is one of the typical disciplines where personalized medicine has been recently becoming an important part of clinical practice. In this article, the brief overview and a number of examples of the use of biomarkers and personalized medicine in neurology are described. The various issues in neurology are described in relation to the personalized medicine and diagnostic, prognostic as well as predictive blood and cerebrospinal fluid biomarkers. Such neurological domains discussed in this work are neuro-oncology and primary brain tumors glioblastoma and oligodendroglioma, cerebrovascular diseases focusing on stroke, neurodegenerative disorders especially Alzheimer's and Parkinson's diseases and demyelinating diseases such as multiple sclerosis...
2016: EPMA Journal
Katarzyna Konieczka, Simone Koch, Tatjana Binggeli, Andreas Schoetzau, Juerg Kesselring
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS of still unknown aetiology. Flammer syndrome (FS) encompasses a set of symptoms and signs that are primarily but not solely related to the dysregulation of blood vessels. The purpose of the present study was to determine whether FS symptoms occur more often in MS patients than in controls. METHODS: Fifty-eight MS patients and 259 controls answered a questionnaire covering 15 symptoms and signs of FS...
2016: EPMA Journal
Priit Niibo, Chris Pruunsild, Ülle Voog-Oras, Tiit Nikopensius, Triin Jagomägi, Mare Saag
Juvenile idiopathic arthritis is the most common chronic rheumatic condition during childhood. Temporomandibular joint arthritis is frequently asymptomatic. When it takes place during childhood, it may affect condylar growth; therefore, these children are at risk of unfavorable long-term outcomes from the associated joint damage. The etiology is not completely understood, but it is considered as multifactorial with both genetic and environmental factors involved. The standardized examination and imaging protocols serve important purpose to diagnose temporomandibular joint (TMJ) arthritis not only to establish an early interventional strategy but also to assess craniofacial growth and the progression of signs and symptoms in those patients...
2016: EPMA Journal
Yevhen V Moiseyenko, Viktor I Sukhorukov, Georgiy Yu Pyshnov, Iryna M Mankovska, Kateryna V Rozova, Olena A Miroshnychenko, Olena E Kovalevska, Stefan-Arpad Y Madjar, Rostyslav V Bubnov, Anatoliy O Gorbach, Kostiantyn M Danylenko, Olga I Moiseyenko
BACKGROUND: Antarctica is a unique place to study the health condition under the influence of environmental factors on the organism in pure form. Since the very beginning of the scientific presence of Ukraine in the Antarctic, biomedical research has been developed for the monitoring of individual biomarkers of winterers and medical accompaniment in Antarctic expeditions. The aim of the study was to analyze and discuss the retrospective data of long-term monitoring and observations in Ukrainian Antarctica station "Akademik Vernadsky," providing multi-scale biomedical information with regard to conditions of a perfect isolation from technological and social influences and under extreme environmental factors...
2016: EPMA Journal
Vasiliki Karadima, Christina Kraniotou, George Bellos, George Th Tsangaris
Micronutrients are indispensable for a variety of vital functions. Micronutrient deficiencies are a global problem concerning two billion people. In most cases, deficiencies are treatable with supplementation of the elements in lack. Drug-nutrient interactions can also lead to micronutrient reduce or depletion by various pathways. Supplementation of the elements and long-term fortification programs for populations at risk can prevent and restore the related deficiencies. Within the context of Predictive, Preventive, and Personalized Medicine, a multi-professional network should be developed in order to identify, manage, and prevent drug-micronutrient interactions that can potentially result to micronutrient deficiencies...
2016: EPMA Journal
Vadim V Tachalov, Lyudmila Y Orekhova, Tatyana V Kudryavtseva, Elena R Isaeva, Ekaterina S Loboda
BACKGROUND: Preventing diseases of oral cavity, specifically periodontal diseases, is currently a high-priority issue. Despite the wide selection of individual oral care products and the abundance of information on individual oral care, the prevalence of tooth decay and inflammatory periodontal diseases remains high. Apart from knowledge of individual oral care, of great importance for patients is their capacity to develop strong motivation for full-scale hygienic procedures. RESULTS: Patients' motivation is immediately interconnected with their personality specifics...
2016: EPMA Journal
Mikhail Paltsev, Vsevolod Kiselev, Vadim Drukh, Ekaterina Muyzhnek, Igor Kuznetsov, Evgeniya Andrianova, Pavel Baranovskiy
BACKGROUND: Targeted pharmacological correction is used extensively in medical practice today. 3,3'-Diindolylmethane (DIM) is known as a substance with various anticancer properties. An interim study of the efficacy of a new drug Infemin on the basis of diindolylmethane (DIM) with improved bioavalability has been conducted. METHODS: The clinical trial had a multicenter, randomized, placebo-controlled, double-blind design and was carried out in two parallel groups...
2016: EPMA Journal
Evgeny F Cherednikov, Anatoly A Kunin, Evgeny E Cherednikov, Natalia S Moiseeva
The article contains an overview of the literature on Mallory-Weiss syndrome. It analyzes numerous etiological factors, provides new insights into the pathogenesis of the disease, gives a description of a previously unknown dependence of discontinuous-hemorrhagic syndrome on the topographic and structural features of the cardioesophageal area of the digestive tract, and gives scientific credence to methods of prediction, prevention, and treatment of the syndrome with complex involvement of granular sorbents...
2016: EPMA Journal
Tamar Kezeli, Tamari Rukhadze, Nikoloz Gongadze, Galina Sukoyan, Nino Dolidze, Mariam Chipashvili, Makrine Mirziashvili
BACKGROUND: Anti-ischemic effects of NO releasing by nitroglycerin (NTG) and the release of calcitonin gene-related peptide (CGRP) are involved in the decrease of vascular remodeling in different cardiovascular diseases. Using a nitrate-free period is still generally required to prevent nitrate tolerance and should be used as the first-line option to maintain adequate symptom control and on an individual basis. Personalized anti-ischemic concerns require the urgent change of paradigm from interventional measures to predictive, preventive, and personalized treatment with organic nitrates and its combination with drugs that may improve prognosis and drugs that can be added for patients who remain symptomatic despite therapy with the other classes of agents...
2016: EPMA Journal
Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Thom Hoedemakers, Sandra Huygen Allianses, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu, Bettina Zippel-Schultz
Chronic diseases are the leading causes of morbidity and mortality in Europe, accounting for more than 2/3 of all death causes and 75 % of the healthcare costs. Heart failure is one of the most prominent, prevalent and complex chronic conditions and is accompanied with multiple other chronic diseases. The current approach to care has important shortcomings with respect to diagnosis, treatment and care processes. A critical aspect of this situation is that interaction between stakeholders is limited and chronic diseases are usually addressed in isolation...
2015: EPMA Journal
Judita Kinkorová
Biobanks are an important compound of personalized medicine and strongly support the scientific progress in stratification of population and biomarker discovery and validation due to progress in personalized medicine. Biobanks are an essential tool for new drug discoveries and drug development. Biobanks play an important role in the whole process of patient prevention and prediction, follow-up, and therapy monitoring and optimalization. Biobanks have the specificity in that they cover multidisciplinary approach to the human health combining biological and medical approaches, as well as informative bioinformatics technologies, computationing, and modeling...
2015: EPMA Journal
Xu Qin, Jun Yao Liu, Rafik Abdelsayed, Xingming Shi, Jack C Yu, Mahmood S Mozaffari, Babak Baban
BACKGROUND: We recently showed that an imbalance between the pro-inflammatory cytokine, interleukin (IL)-17, and the developmental endothelial locus-1 (Del-1) likely contributes to inflammation and salivary gland abnormalities in Sjögren's syndrome (SS). The glucocorticoid-induced leucine zipper (GILZ) protein is a pivotal player in mediating the anti-inflammatory effects of glucocorticoids. However, its status and role in salivary gland inflammation and dysfunction in SS are not established...
2015: EPMA Journal
Stefanie Schulte, Natalie N Rasmussen, Joseph W McBeth, Patrick Q Richards, Eric Yochem, David J Petron, Frederick G Strathmann
BACKGROUND: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team. METHODS: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making...
2015: EPMA Journal
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