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EPMA Journal

Johann Lechner, Sammy Noumbissi, Volker von Baehr
Background and introduction: It is a well-known fact that titanium particles deriving from dental titanium implants (DTI) dissolve into the surrounding bone. Although titanium (TI) is regarded as a compatible implant material, increasing concern is coming up that the dissolved titanium particles induce inflammatory reactions around the implant. Specifically, the inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is expressed in the adjacent bone. The transition from TNF-α-induced local inflammation following insertion of DTI surgery to a chronic stage of "silent inflammation" could be a neglected cause of unexplained medical conditions...
September 2018: EPMA Journal
Natalia S Moiseeva, Anatoly A Kunin, Cenk M Haytac
The most important problems of modern dentistry cover not only the early diagnosis but also prevention of dental caries, including the one based on the use of various hygienic products and therapeutic agents. Normally, the processes of re- and demineralization in the oral cavity are in a state of dynamic. However, in the presence of cariogenic factors, the balance is shifted towards demineralization. In the event of initial caries, enamel remineralization is possible only to a certain extent, and specifically, for a reversible degree of carious lesion...
September 2018: EPMA Journal
Analtoly Kunin, Jiri Polivka, Natalia Moiseeva, Olga Golubnitschaja
Background: "Dry mouth" syndrome (chronic hyposalivation) can be caused by a number of pathophysiological conditions such as acute and chronic stress exposure, abnormal body weight (both too high and too low ones), eating disorders (such as anorexia nervosa ), metabolic syndrome(s), Sjögren's and Sicca syndromes, drugs and head/neck radiotherapy application. In turn, the chronic hyposalivation as a suboptimal health condition significantly reduces quality of life, may indicate a systemic dehydration, provokes and contributes to a number of pathologies such as a strongly compromised protection of the oral cavity, chronic infections and inflammatory processes, periodontitis, voice and digestive disorders...
September 2018: EPMA Journal
Yu-Xiang Yan, Li-Juan Wu, Huan-Bo Xiao, Shuo Wang, Jing Dong, Wei Wang
Background: Chronic stress is associated with suboptimal health status (SHS) which is a new public health challenge in China and worldwide. Plasma stress hormones may act as potential objective biomarkers for SHS measure. This study was aimed to evaluate the diagnostic performance of plasma cortisol, catecholamine adrenaline/noradrenaline, and SHS questionnaires (SHSQ) for SHS using latent class analysis (LCA) in the absence of a gold standard. Methods: A cross-sectional study was conducted among 868 employees in Beijing...
September 2018: EPMA Journal
Jun Hwa Lee, Seung Eun Yu, Kyung-Hee Kim, Myung Hyun Yu, In-Hye Jeong, Jae Youl Cho, Sang-Jae Park, Woo Jin Lee, Sung-Sik Han, Tae Hyun Kim, Eun Kyung Hong, Sang Myung Woo, Byong Chul Yoo
Background: Pancreatic cancer (PC) and biliary tract cancer (BTC) are highly aggressive cancers, characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. Diagnosis of PC and BTC is complex and is made using a combination of appropriate clinical suspicion, imaging and endoscopic techniques, and cytopathological examination. However, the late-stage detection and poor prognosis of this tumor have led to an urgent need for biomarkers for early and/or predictive diagnosis and improved personalized treatments...
September 2018: EPMA Journal
Olga Golubnitschaja, Jiri Polivka, Kristina Yeghiazaryan, Leonard Berliner
Background: The annually recorded incidence of primary hepatic carcinomas has significantly increased over the past two decades accounting for over 800 thousand of annual deaths caused by hepatocellular carcinoma (HCC) alone globally. Further, secondary liver malignancies are much more widespread compared to primary hepatic carcinomas: almost all solid malignancies are able to metastasise into the liver. The primary tumours most frequently metastasising to the liver are breast followed by colorectal carcinomas...
September 2018: EPMA Journal
Pavol Zubor, Peter Kubatka, Ivana Kapustova, Lence Miloseva, Zuzana Dankova, Alexandra Gondova, Tibor Bielik, Stefan Krivus, Jan Bujnak, Zuzana Laucekova, Christina Kehrer, Erik Kudela, Jan Danko
Malignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC-the issue which has strongly motivated our current paper...
September 2018: EPMA Journal
Nadja Borisow, Kerstin Hellwig, Friedemann Paul
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune inflammatory diseases of the central nervous system that predominately affect women. Some of these patients are of childbearing age at NMOSD onset. This study reviews, on the one hand, the role NMOSD play in fertility, pregnancy complications and pregnancy outcome, and on the other, the effect of pregnancy on NMOSD disease course and treatment options available during pregnancy. Animal studies show lower fertility rates in NMOSD; however, investigations into fertility in NMOSD patients are lacking...
September 2018: EPMA Journal
Michael J Zellweger, Andrew Tsirkin, Vasily Vasilchenko, Michael Failer, Alexander Dressel, Marcus E Kleber, Peter Ruff, Winfried März
Background: Known coronary artery disease (CAD) risk scores (e.g., Framingham) estimate the CAD-related event risk rather than presence/absence of CAD. Artificial intelligence (AI) is rarely used in this context. Aims: This study aims to evaluate the diagnostic power of AI (memetic pattern-based algorithm (MPA)) in CAD and to expand its applicability to a broader patient population. Methods and results: Nine hundred eighty-seven patients of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) were divided into a training ( n  = 493) and a test population ( n  = 494)...
September 2018: EPMA Journal
Rony Jose, Robert Rooney, Naga Nagisetty, Robert Davis, David Hains
Current healthcare is evolving to emphasize cost-effective care by leveraging results and outcomes of genomic and other advanced research efforts in clinical care and preventive health planning. Through a collaborative effort between the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children's Hospital (LBCH), the Biorepository and Integrative Genomics (BIG) Initiative was established to set up a pediatric-based DNA biorepository that can serve as a foundation for successful development of delivery platforms for predictive, preventive, and personalized medical services in Memphis, Tennessee, a historically disadvantaged community in the USA...
September 2018: EPMA Journal
Rostyslav V Bubnov, Lidiia P Babenko, Liudmyla M Lazarenko, Victoria V Mokrozub, Mykola Ya Spivak
Background: Probiotics have tremendous potential to develop healthy diets, treatment, and prevention. Investigation of in vitro cultural properties of health-promoting microorganisms like lactic acid bacteria (LAB) and bifidobacteria is crucial to select probiotic strains for treatments based on gut microbiota modulation to justify individualized and personalized approach for nutrition and prevention of variety of diseases. The aim was to study the biological properties of LAB and bifidobacteria probiotic strains, namely adhesive properties; resistance to antibiotics; and biological fluids (gastric juice, bile, pancreatic enzymes), and to overview the literature in the field...
June 2018: EPMA Journal
Pavel Seredin, Dmitry Goloshchapov, Yuri Ippolitov, Pimm Vongsvivut
Background: Improving the quality of life is part of the global agenda. The focus is predominantly on prevention of socially significant diseases. Combating dental caries-related diseases is a top priority as it has a huge impact on people's social lives. Therefore, the purpose of the work was to study the changes in the molecular composition of saliva from subjects with multiple caries lesions using spectroscopic methods of analysis to identify potential tissue markers of caries development for predictive, preventive and personalised medical services...
June 2018: EPMA Journal
Jana Olak, Minh Son Nguyen, Thuy Trang Nguyen, Bui Bao Tien Nguyen, Mare Saag
Objective: The study aims to investigate how mothers' oral health behaviour and perception thereof influence the dental health in their children. Methods: A total of 556 Vietnamese mother-child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anxiety level in mothers and children...
June 2018: EPMA Journal
Holger Fröhlich, Sabyasachi Patjoshi, Kristina Yeghiazaryan, Christina Kehrer, Walther Kuhn, Olga Golubnitschaja
Background: The breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries...
June 2018: EPMA Journal
Nasser Davarzani, Sandra Sanders-van Wijk, Micha T Maeder, Peter Rickenbacher, Evgueni Smirnov, Joël Karel, Thomas Suter, Rudolf A de Boer, Dirk Block, Vinzent Rolny, Christian Zaugg, Matthias E Pfisterer, Ralf Peeters, Hans-Peter Brunner-La Rocca
Background: It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods: This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged ≥ 60 years, LVEF ≤ 45%, and NYHA ≥ II, who had repeated clinical visits within 19 months follow-up...
June 2018: EPMA Journal
Bernhard A Sabel, Jiaqi Wang, Lizbeth Cárdenas-Morales, Muneeb Faiq, Christine Heim
The loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly a consequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nervous system (sympathetic) imbalance and vascular dysregulation; hence stress may also be one of the major causes of visual system diseases such as glaucoma and optic neuropathy...
June 2018: EPMA Journal
Alexandre Assuane Duarte, Shahriar Mohsin, Olga Golubnitschaja
Diabetes mellitus (DM) epidemic-on a global scale-is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0...
June 2018: EPMA Journal
Jaak Ph Janssens, Klaus Schuster, Andreas Voss
Preventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and risk sustainability for the health care system...
June 2018: EPMA Journal
Peter Balicza, Andras Terebessy, Zoltan Grosz, Noemi Agnes Varga, Aniko Gal, Balint Andras Fekete, Maria Judit Molnar
Objective: Next-generation sequencing is increasingly utilized worldwide as a research and diagnostic tool and is anticipated to be implemented into everyday clinical practice. Since Central-Eastern European attitude toward genetic testing, especially broad genetic testing, is not well known, we performed a survey on this issue among Hungarian participants. Methods: A self-administered questionnaire was distributed among patients and patient relatives at our neurogenetic outpatient clinic...
March 2018: EPMA Journal
Miaolong Lu, Xianquan Zhan
Cancer with heavily economic and social burden is the hot point in the field of medical research. Some remarkable achievements have been made; however, the exact mechanisms of tumor initiation and development remain unclear. Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics and radiomics aims to systematically understand carcinogenesis in different biological levels, which is driving the shift of cancer research paradigm from single parameter model to multi-parameter systematical model...
March 2018: EPMA Journal
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