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EPMA Journal

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https://www.readbyqxmd.com/read/29896319/specific-properties-of-probiotic-strains-relevance-and-benefits-for-the-host
#1
Rostyslav V Bubnov, Lidiia P Babenko, Liudmyla M Lazarenko, Victoria V Mokrozub, Mykola Ya Spivak
Background: Probiotics have tremendous potential to develop healthy diets, treatment, and prevention. Investigation of in vitro cultural properties of health-promoting microorganisms like lactic acid bacteria (LAB) and bifidobacteria is crucial to select probiotic strains for treatments based on gut microbiota modulation to justify individualized and personalized approach for nutrition and prevention of variety of diseases. The aim was to study the biological properties of LAB and bifidobacteria probiotic strains, namely adhesive properties; resistance to antibiotics; and biological fluids (gastric juice, bile, pancreatic enzymes), and to overview the literature in the field...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896318/pathology-specific-molecular-profiles-of-saliva-in-patients-with-multiple-dental-caries-potential-application-for-predictive-preventive-and-personalised-medical-services
#2
Pavel Seredin, Dmitry Goloshchapov, Yuri Ippolitov, Pimm Vongsvivut
Background: Improving the quality of life is part of the global agenda. The focus is predominantly on prevention of socially significant diseases. Combating dental caries-related diseases is a top priority as it has a huge impact on people's social lives. Therefore, the purpose of the work was to study the changes in the molecular composition of saliva from subjects with multiple caries lesions using spectroscopic methods of analysis to identify potential tissue markers of caries development for predictive, preventive and personalised medical services...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896317/the-influence-of-mothers-oral-health-behaviour-and-perception-thereof-on-the-dental-health-of-their-children
#3
Jana Olak, Minh Son Nguyen, Thuy Trang Nguyen, Bui Bao Tien Nguyen, Mare Saag
Objective: The study aims to investigate how mothers' oral health behaviour and perception thereof influence the dental health in their children. Methods: A total of 556 Vietnamese mother-child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anxiety level in mothers and children...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896316/premenopausal-breast-cancer-potential-clinical-utility-of-a-multi-omics-based-machine-learning-approach-for-patient-stratification
#4
Holger Fröhlich, Sabyasachi Patjoshi, Kristina Yeghiazaryan, Christina Kehrer, Walther Kuhn, Olga Golubnitschaja
Background: The breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896315/novel-concept-to-guide-systolic-heart-failure-medication-by-repeated-biomarker-testing-results-from-time-chf-in-context-of-predictive-preventive-and-personalized-medicine
#5
Nasser Davarzani, Sandra Sanders-van Wijk, Micha T Maeder, Peter Rickenbacher, Evgueni Smirnov, Joël Karel, Thomas Suter, Rudolf A de Boer, Dirk Block, Vinzent Rolny, Christian Zaugg, Matthias E Pfisterer, Ralf Peeters, Hans-Peter Brunner-La Rocca
Background: It is uncertain whether repeated measurements of a multi-target biomarker panel may help to personalize medical heart failure (HF) therapy to improve outcome in chronic HF. Methods: This analysis included 499 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF), aged ≥ 60 years, LVEF ≤ 45%, and NYHA ≥ II, who had repeated clinical visits within 19 months follow-up...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896314/mental-stress-as-consequence-and-cause-of-vision-loss-the-dawn-of-psychosomatic-ophthalmology-for-preventive-and-personalized-medicine
#6
REVIEW
Bernhard A Sabel, Jiaqi Wang, Lizbeth Cárdenas-Morales, Muneeb Faiq, Christine Heim
The loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly a consequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nervous system (sympathetic) imbalance and vascular dysregulation; hence stress may also be one of the major causes of visual system diseases such as glaucoma and optic neuropathy...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896313/diabetes-care-in-figures-current-pitfalls-and-future-scenario
#7
REVIEW
Alexandre Assuane Duarte, Shahriar Mohsin, Olga Golubnitschaja
Diabetes mellitus (DM) epidemic-on a global scale-is a major and snowballing threat to public health, healthcare systems and economy, due to the cascade of pathologies triggered in a long-term manner after the DM manifestation. There are remarkable differences in the geographic disease spread and acceleration of an increasing DM prevalence recorded. Specifically, the highest initial prevalence of DM was recorded in the Eastern-Mediterranean region in 1980 followed by the highest acceleration of the epidemic characterised by 0...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29896312/preventive-predictive-and-personalized-medicine-for-effective-and-affordable-cancer-care
#8
REVIEW
Jaak Ph Janssens, Klaus Schuster, Andreas Voss
Preventive, predictive, and personalized medicine (PPPM) has created a wealth of new opportunities but added also new complexities and challenges. The European Cancer Prevention Organization already embraced unanimously molecular biology for primary and secondary prevention. The rapidly exploding genomic language and complexity of methods face oncologists with exponentially growing knowledge they need to assess and apply. Tissue specimen quality becomes one major concern. Some new innovative medicines cost beyond any reasonable threshold of financial support from patients, health care providers, and governments and risk sustainability for the health care system...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515690/implementation-of-personalized-medicine-in-central-eastern-europe-pitfalls-and-potentials-based-on-citizen-s-attitude
#9
Peter Balicza, Andras Terebessy, Zoltan Grosz, Noemi Agnes Varga, Aniko Gal, Balint Andras Fekete, Maria Judit Molnar
Objective: Next-generation sequencing is increasingly utilized worldwide as a research and diagnostic tool and is anticipated to be implemented into everyday clinical practice. Since Central-Eastern European attitude toward genetic testing, especially broad genetic testing, is not well known, we performed a survey on this issue among Hungarian participants. Methods: A self-administered questionnaire was distributed among patients and patient relatives at our neurogenetic outpatient clinic...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515689/the-crucial-role-of-multiomic-approach-in-cancer-research-and-clinically-relevant-outcomes
#10
REVIEW
Miaolong Lu, Xianquan Zhan
Cancer with heavily economic and social burden is the hot point in the field of medical research. Some remarkable achievements have been made; however, the exact mechanisms of tumor initiation and development remain unclear. Cancer is a complex, whole-body disease that involves multiple abnormalities in the levels of DNA, RNA, protein, metabolite and medical imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics and radiomics aims to systematically understand carcinogenesis in different biological levels, which is driving the shift of cancer research paradigm from single parameter model to multi-parameter systematical model...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515688/high-regenerative-capacity-of-the-liver-and-irreversible-injury-of-male-reproductive-system-in-carbon-tetrachloride-induced-liver-fibrosis-rat-model
#11
Rostyslav V Bubnov, Maria V Drahulian, Polina V Buchek, Tamara P Gulko
Background: Liver fibrosis (LF) is a chronic disease, associated with many collateral diseases including reproductive dysfunction. Although the normal liver has a large regenerative capacity the complications of LF could be severe and irreversible. Hormone and sex-related issues of LF development and interactions with male reproductive have not been finally studied. The aim was to study the reproductive function of male rats in experimental CCl4 -induced liver fibrosis rat model, and the capability for restoration of both the liver and male reproduction system...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515687/clinical-and-laboratory-evaluation-of-microstructural-changes-in-the-physical-mechanical-and-chemical-properties-of-dental-filling-materials-under-the-influence-of-an-electromagnetic-field
#12
Natalia S Moiseeva, Anatoly A Kunin
Restorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515686/heart-rate-variability-the-comparison-between-high-tension-and-normal-tension-glaucoma
#13
Natalia Ivanovna Kurysheva, Tamara Yakovlevna Ryabova, Vitaliy Nikiforovich Shlapak
Relevance: Vascular factors may be involved in the development of both high tension glaucoma (HTG) and normal tension (NTG) glaucoma; however, they may be not exactly the same. Autonomic dysfunction characterized by heart rate variability (HRV) is one of the possible reasons of decrease in mean ocular perfusion pressure (MOPP). Purpose: To compare the shift of the HRV parameters in NTG and HTG patients after a cold provocation test (CPT). Methods: MOPP, 24-hour blood pressure and HRV were studied in 30 NTG, 30 HTG patients, and 28 healthy subjects...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515685/optical-coherence-tomography-in-neuromyelitis-optica-spectrum-disorders-potential-advantages-for-individualized-monitoring-of-progression-and-therapy
#14
REVIEW
Frederike C Oertel, Hanna Zimmermann, Friedemann Paul, Alexander U Brandt
Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related clinical event in 55% of the patients, which causes damage to the optic nerve and leads to visual impairment. Retinal optical coherence tomography (OCT) has emerged as a promising method for diagnosis of NMOSD and potential individual monitoring of disease course and severity. OCT not only detects damage to the afferent visual system caused by ON but potentially also NMOSD-specific intraretinal pathology, i...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515684/individualised-patient-profile-clinical-utility-of-flammer-syndrome-phenotype-and-general-lessons-for-predictive-preventive-and-personalised-medicine
#15
REVIEW
Olga Golubnitschaja, Josef Flammer
This case report introduces a female patient, who since her teenager age evidently suffers from Flammer syndrome (FS) as the clearly defined sub-optimal health condition. Further, the patient has experienced collateral pathological conditions which primarily might be linked to the family (genetic) predisposition, but the development of which could be synergistically promoted by the FS-phenotype. The facts are thoroughly analysed and consequent hypotheses are presented, which are indicative for highly desirable predictive diagnostics and targeted preventive measures to be created based on the accurate interpretation of the individualised patient profile...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29515683/pregnancy-associated-breast-cancer-the-risky-status-quo-and-new-concepts-of-predictive-medicine
#16
REVIEW
Jiri Polivka, Irem Altun, Olga Golubnitschaja
The paper is motivated by severe concerns regarding currently applied care of the pregnancy-associated breast cancer (PABC) characterised by particularly poor outcomes of the disease. Psychological and ethical aspects play a crucial role in PABC: the highest priority not to damage the foetus significantly complicates any treatment generally, and it is quite usual that patients disclaim undergoing any breast cancer treatment during pregnancy. Although, due to global demographic trends, PABC is far from appearing rarely now, severe societal and economic consequences of the disease are still neglected by currently applied reactive medical approach...
March 2018: EPMA Journal
https://www.readbyqxmd.com/read/29209441/pcsk9-signaling-pathways-and-their-potential-importance-in-clinical-practice
#17
REVIEW
Michał Wiciński, Jarosław Żak, Bartosz Malinowski, Gabriela Popek, Grzegorz Grześk
In the following review, authors described the structure and biochemical pathways of PCSK9, its involvement in LDL metabolism, as well as significances of proprotein convertase subtilisin/kexin type 9 targeted treatment. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. Transcription and translation of PCSK9 is controlled by different nuclear factors, such as, SREBP and HNF1α. This review focuses on interactions between PCSK9 and LDL receptor, VLDLR, ApoER2, CD36, CD81, and others...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29209440/efficacy-of-fenugreek-based-bionanocomposite-on-renal-dysfunction-and-endogenous-intoxication-in-high-calorie-diet-induced-obesity-rat-model-comparative-study
#18
Victoria V Konopelniuk, Ievgenii I Goloborodko, Tetyana V Ishchuk, Tetyana B Synelnyk, Ludmila I Ostapchenko, Mykola Ya Spivak, Rostyslav V Bubnov
Background: Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as non-alcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29209439/comparative-study-of-probiotic-effects-of-lactobacillus-and-bifidobacteria-strains-on-cholesterol-levels-liver-morphology-and-the-gut-microbiota-in-obese-mice
#19
Rostyslav V Bubnov, Lidiia P Babenko, Liudmyla M Lazarenko, Viktoria V Mokrozub, Oleksandr A Demchenko, Oleksiy V Nechypurenko, Mykola Ya Spivak
Background: Microbiome-modulating interventions are promising for treatment and prevention of metabolic syndrome. The number of probiotic strains demonstrated ability to decrease cholesterol level in vivo, however, it was poorly confirmed in a clinical setting. The aim was to study the effects of L. acidophilus IMV B-7279, L. casei IMV B-7280, B. animalіs VKL and B. animalіs VKB separately and in various compositions on the level of serum cholesterol, gut microbiota contents and liver morphology on a high-calorie-induced obesity model in BALB/c mice...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29209438/incorporation-of-suboptimal-health-status-as-a-potential-risk-assessment-for-type-ii-diabetes-mellitus-a-case-control-study-in-a-ghanaian-population
#20
Eric Adua, Peter Roberts, Wei Wang
Due to a paradigm shift in lifestyles, there is growing concern that type 2 diabetes mellitus (T2DM) will reach epidemic proportions in Ghana. However, specific characteristics of the disease are under explored in this region. More challenging are those yet to be diagnosed or who complain of poor health in the absence of a diagnosed disease-suboptimal health status (SHS). We conducted a study to examine various factors that characterise SHS and T2DM. Using a cross-sectional design, we recruited 264 people as controls and 241 T2DM patients from January to June 2016...
December 2017: EPMA Journal
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