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Translational Stroke Research

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https://www.readbyqxmd.com/read/28283966/data-standardization-and-quality-management
#1
Paul A Lapchak, John H Zhang
Important questions regarding the conduct of scientific research and data transparency have been raised in various scientific forums over the last 10 years. It is becoming clear, that in spite of published RIGOR guidelines, that improvement in the transparency of scientific research is required to focus on the discovery and drug development process so that a treatment can be provided to stroke patients. We have the unique privilege of conducting research using animal models of a disease so that we can address the development of a new therapy, and we should do this with great care and vigilance...
March 10, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28281221/evidence-for-decreased-brain-parenchymal-volume-after-large-intracerebral-hemorrhages-a-potential-mechanism-limiting-intracranial-pressure-rises
#2
Michael R Williamson, Frederick Colbourne
Potentially fatal intracranial pressure (ICP) rises commonly occur after large intracerebral hemorrhages (ICH). We monitored ICP after infusing 100-160 μL of autologous blood (vs. 0 μL control) into the striatum of rats in order to test the validity of this common model with regard to ICP elevations. Other endpoints included body temperature, behavioral impairment, lesion volume, and edema. Also, we evaluated hippocampal CA1 sector and somatosensory cortical neuron morphology to assess whether global ischemic injury occurred...
March 9, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28271393/translational-stroke-research-opportunities-and-a-strategy-to-develop-effective-cytoprotection
#3
EDITORIAL
Paul A Lapchak
No abstract text is available yet for this article.
March 8, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28265861/re-evaluate-the-efficacy-and-safety-of-human-urinary-kallidinogenase-resk-protocol-for-an-open-label-single-arm-multicenter-phase-iv-trial-for-the-treatment-of-acute-ischemic-stroke-in-chinese-patients
#4
Jun Ni, Jiazhi Qu, Ming Yao, Zhijun Zhang, Xihua Zhong, Liying Cui
Acute ischemic stroke (AIS) is a major medical challenge in China. Thrombolytic drugs recommended for the treatment of AIS usually have a narrow time window. Human urinary kallidinogenase (HUK) was approved by the China Food and Drug Administration (CFDA) in 2005 for the treatment of mild to moderate AIS, and it is thus widely used in China. However, large-scale clinical study data for a more complete understanding of various aspects of its safety and efficacy characteristics are still unavailable. The ongoing Reevaluate the Efficacy and Safety of Human Urinary Kallidinogenase (RESK) trial is designed to reevaluate the safety and efficacy of HUK in Chinese patients with AIS...
March 6, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28247188/diabetes-worsens-functional-outcomes-in-young-female-rats-comparison-of-stroke-models-tissue-plasminogen-activator-effects-and-sexes
#5
Weiguo Li, Rebecca Ward, John Paul Valenzuela, Guangkuo Dong, Susan C Fagan, Adviye Ergul
Diabetes worsens stroke outcome and increases the risk of hemorrhagic transformation (HT) after ischemic stroke, especially with tissue plasminogen activator (tPA) treatment. The widespread use of tPA is still limited by the fear of hemorrhagic transformation (HT), and underlying mechanisms are actively being pursued in preclinical studies. However, experimental models use a 10 times higher dose of tPA than the clinical dose (10 mg/kg) and mostly employ only male animals. In this translational study, we hypothesized that low-dose tPA will improve the functional recovery after the embolic stroke in both control and diabetic male and female animals...
March 1, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28243834/sodium-tanshinone-iia-sulfonate-enhances-effectiveness-rt-pa-treatment-in-acute-ischemic-stroke-patients-associated-with-ameliorating-blood-brain-barrier-damage
#6
Biying Ji, Fei Zhou, Lijuan Han, Jun Yang, Haijian Fan, Shanshan Li, Jingwei Li, Xin Zhang, Xiaoying Wang, Xiangyan Chen, Yun Xu
Treatment with sodium tanshinone IIA sulfonate (STS) may ameliorate blood-brain barrier (BBB) damage in acute ischemic stroke patients receiving recombinant tissue plasminogen activator (rt-PA) thrombolysis and improve stroke patients' outcome. This randomized, single-center, placebo-controlled clinical trial investigated the potential effects and underlying mechanisms of STS. Forty-two acute ischemic stroke patients receiving intravenous rt-PA thrombolysis were randomized to intravenous administration either with STS (60 mg/day) (n = 21) or with equivalent volume of saline as a placebo (n = 21) after randomization for 10 days...
February 27, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28236151/can-quality-improvement-tools-overcome-the-translational-roadblock-the-vital-influence-of-the-researcher
#7
EDITORIAL
Serge Marbacher
No abstract text is available yet for this article.
February 24, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28205065/spontaneous-recovery-of-upper-extremity-motor-impairment-after-ischemic-stroke-implications-for-stem-cell-based-therapeutic-approaches
#8
Hossein Delavaran, Joseph Aked, Håkan Sjunnesson, Olle Lindvall, Bo Norrving, Zaal Kokaia, Arne Lindgren
Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. To evaluate the feasibility of post-stroke UEMI as a target for SCT, we examined a selected sample of stroke patients potentially suitable for SCT, aiming to assess the frequency and recovery of UEMI, as well as its relation to activity limitations and participation restrictions. Patients aged 20-75 years with first-ever ischemic stroke, and National Institutes of Health Stroke Scale (NIHSS) scores 1-18, underwent brain diffusion-weighted MRI within 4 days of stroke onset (n = 108)...
February 15, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28138916/a-systematic-and-meta-analysis-of-mortality-in-experimental-mouse-models-analyzing-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage
#9
Marcel A Kamp, Jasper H van Lieshout, Maxine Dibué-Adjei, Jasmin K Weber, Toni Schneider, Tanja Restin, Igor Fischer, Hans-Jakob Steiger
Animal models are established to display the pathophysiological changes following subarachnoid hemorrhage (SAH). The aim of the present study was to determine case fatality in mouse delayed cerebral ischemia (DCI) models, to compare mortality in mouse DCI models to case fatality in human SAH patients, and to identify factors influencing mouse mortality. A systematic search of the PubMed database was performed to identify all studies that assessed mouse DCI models. Mortality rates and predictor variables were extracted and compared to the human case fatality after SAH as previously reported...
January 30, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28102508/simvastatin-promotes-hematoma-absorption-and-reduces-hydrocephalus-following-intraventricular-hemorrhage-in-part-by-upregulating-cd36
#10
Qianwei Chen, Xia Shi, Qiang Tan, Zhou Feng, Yuelong Wang, Qiaoying Yuan, Yihao Tao, Jianbo Zhang, Liang Tan, Gang Zhu, Hua Feng, Zhi Chen
We previously found that hematoma worsens hydrocephalus after intraventricular hemorrhage (IVH) via increasing iron deposition and aggravating ependymal cilia injury; therefore, promoting hematoma absorption may be a promising strategy for IVH. Recently, some investigations imply that simvastatin has the ability of accelerating hematoma absorption. Thus, this study was designed to examine the efficacy of simvastatin for IVH in rats. Intracerebral hemorrhage with ventricular extension was induced in adult male Sprague-Dawley rats after autologous blood injection...
January 19, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28101763/mir-126-affects-brain-heart-interaction-after-cerebral-ischemic-stroke
#11
Jieli Chen, Chengcheng Cui, Xiaoping Yang, Jiang Xu, Poornima Venkat, Alex Zacharek, Peng Yu, Michael Chopp
Cardiovascular diseases are approximately three times higher in patients with neurological deficits than in patients without neurological deficits. MicroRNA-126 (MiR-126) facilitates vascular remodeling and decreases fibrosis and is emerging as an important factor in the pathogenesis of cardiovascular diseases and cerebral stroke. In this study, we tested the hypothesis that decreased miR-126 after ischemic stroke may play an important role in regulating cardiac function. Wild-type (WT), specific conditional-knockout endothelial cell miR-126 (miR-126(EC-/-)), and miR-126 knockout control (miR-126(fl/fl)) mice were subjected to distal middle cerebral artery occlusion (dMCAo) (n = 10/group)...
January 19, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28091936/task-specific-motor-rehabilitation-therapy-after-stroke-improves-performance-in-a-different-motor-task-translational-evidence
#12
M El Amki, P Baumgartner, O Bracko, A R Luft, S Wegener
While the stroke survivor with a motor deficit strives for recovery of all aspects of daily life movements, neurorehabilitation training is often task specific and does not generalize to movements other than the ones trained. In rodent models of post-stroke recovery, this problem is poorly investigated as the training task is often the same as the one that measures motor function. The present study investigated whether motor training by pellet reaching translates into enhancement of different motor functions in rats after stroke...
January 14, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28039577/antiplatelet-strategies-and-outcomes-in-patients-with-noncardioembolic-ischemic-stroke-from-a-real-world-study-with-a-five-year-follow-up
#13
Huimin Xu, Yanting Ping, Haoran Lin, Ping He, Wenlu Li, Haibin Dai
Aspirin and clopidogrel are both acceptable antiplatelet options for the secondary prevention of noncardioembolic ischemic stroke. Associations between Essen Stroke Risk Score (ESRS) and antiplatelet treatment in Chinese patients with noncardioembolic ischemic stroke were assessed. This retrospective study was taken in a tertiary care hospital located in eastern China. Patients with noncardioembolic ischemic stroke hospitalized during January 1, 2009, to December 31, 2011, were classified according to ESRS during index stroke hospitalization...
December 31, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/28039575/the-high-cost-of-stroke-and-stroke-cytoprotection-research
#14
Paul A Lapchak, John H Zhang
Acute ischemic stroke is inadequately treated in the USA and worldwide due to a lengthy history of neuroprotective drug failures in clinical trials. The majority of victims must endure life-long disabilities that not only affect their livelihood, but also have an enormous societal economic impact. The rapid development of a neuroprotective or cytoprotective compound would allow future stroke victims to receive a treatment to reduce disabilities and further promote recovery of function. This opinion article reviews in detail the enormous costs associated with developing a small molecule to treat stroke, as well as providing a timely overview of the cell-death time-course and relationship to the ischemic cascade...
December 30, 2016: Translational Stroke Research
https://www.readbyqxmd.com/read/28251583/stroke-cytoprotection-can-repeating-history-with-new-expectations-really-be-the-path-to-success-in-stroke-research
#15
LETTER
Paul A Lapchak, Victor V Uteshev
No abstract text is available yet for this article.
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28127687/regulated-and-unregulated-clinical-trials-of-stem-cell-therapies-for-stroke
#16
EDITORIAL
Michael G Liska, Marci G Crowley, Cesar V Borlongan
No abstract text is available yet for this article.
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/27838820/increased-12-15-lipoxygenase-leads-to-widespread-brain-injury-following-global-cerebral-ischemia
#17
Kazim Yigitkanli, Yi Zheng, Anton Pekcec, Eng H Lo, Klaus van Leyen
Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury in experimental stroke, but a possible role in brain injury following global ischemia has to date not been investigated. Using a mouse bilateral occlusion model of transient global ischemia which produced surprisingly widespread injury to cortex, striatum, and hippocampus, we show here that 12/15-LOX is increased in a time-dependent manner in the vasculature and neurons of both cortex and hippocampus...
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/27837475/pericytes-in-brain-injury-and-repair-after-ischemic-stroke
#18
REVIEW
Wei Cai, Huan Liu, Jingyan Zhao, Lily Y Chen, Jun Chen, Zhengqi Lu, Xiaoming Hu
Pericytes are functional components of the neurovascular unit (NVU). They provide support to other NVU components and maintain normal physiological functions of the blood-brain barrier (BBB). The brain ischemia and reperfusion result in pathological alterations in pericytes. The intimate anatomical and functional interactions between pericytes and other NVU components play pivotal roles in the progression of stroke pathology. In this review, we depict the biology and functions of pericytes in the normal brain and discuss their effects in brain injury and repair after ischemia/reperfusion...
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/27807801/role-of-glibenclamide-in-brain-injury-after-intracerebral-hemorrhage
#19
Bing Jiang, Lin Li, Qianwei Chen, Yihao Tao, Liming Yang, Bo Zhang, John H Zhang, Hua Feng, Zhi Chen, Jun Tang, Gang Zhu
Brain edema following intracerebral hemorrhage (ICH) causes severe secondary brain injury, and no efficient pharmacological preventions are available. The present study was designed to demonstrate the neuroprotective effects of glibenclamide on brain edema and key factors of the blood-brain barrier (BBB). The study was divided into two parts. First, we utilized an autoblood-induced rat model to investigate the expression of sulfonylurea receptor 1 (Sur1). Second, rats were randomized into sham, vehicle, and glibenclamide groups...
April 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/27783383/early-erythrolysis-in-the-hematoma-after-experimental-intracerebral-hemorrhage
#20
Ge Dang, Yuefan Yang, Gang Wu, Ya Hua, Richard F Keep, Guohua Xi
Erythrolysis occurs in the clot after intracerebral hemorrhage (ICH), and the release of hemoglobin causes brain injury, but it is unclear when such lysis occurs. The present study examined early erythrolysis in rats. ICH rats had an intracaudate injection of 100 μl autologous blood, and sham rats had a needle insertion. All rats had T2 and T2* magnetic response imaging (MRI) scanning, and brains were used for histology and CD163 (a hemoglobin scavenger receptor) and DARPP-32 (a neuronal marker) immunohistochemistry...
April 2017: Translational Stroke Research
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