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Translational Stroke Research

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https://www.readbyqxmd.com/read/29333567/predictors-for-intracranial-hemorrhage-following-intravenous-thrombolysis-in-posterior-circulation-stroke
#1
Dorňák Tomáš, Král Michal, Sedláčková Zuzana, Šaňák Daniel, Čecháková Eva, Divišová Petra, Zapletalová Jana, Kaňovský Petr
Intravenous thrombolysis (IVT) is a standard treatment for anterior (ACS) and posterior circulation stroke (PCS). However, due to the low occurrence of PCS and of intracranial hemorrhage (ICH) in PCS, the knowledge about ICH predictors following IVT in PCS is sparse. Our aim was to identify predictors for ICH following IVT in PCS. The set consisted of 1281 consecutive ischemic stroke (IS) patients treated with IVT, out of which 158 (103 males; mean age 65.6 ± 12.3 years) had PCS. Collected data include baseline characteristics, common stroke risk factors, pre-medication, stroke severity, admission blood glucose level, blood pressure and treatment with intravenous antihypertensive therapy before and during IVT, occlusion of arteries, recanalization rate, time to treatment, and clinical outcome at day 90...
January 15, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29330712/correction-to-pre-existing-small-vessel-disease-in-patients-with-acute-stroke-from-the-middle-east-southeast-asia-and-philippines
#2
Naveed Akhtar, Abdul Salam, Saadat Kamran, Atlantic D'Souza, Yahia Imam, Pablo Garcia Bermejo, Muhammad Faisal Wadiwala, Ahmed Own, Ahmed ElSotouhy, Surjith Vattoth, Paula Bourke, Zain Bhutta, Sujatha Joseph, Mark Santos, Rabia Ali Khan, Ashfaq Shuaib
The author names "Dr. Pablo Garcia Bermejo" and "Dr. Muhammad Faisal Wadiwala" needed to be added as the 6th and 7th authors, respectively. The authors regret this error.
January 13, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29322481/influence-of-thrombolysis-on-the-safety-and-efficacy-of-blocking-platelet-adhesion-or-secretory-activity-in-acute-ischemic-stroke-in-mice
#3
Michael K Schuhmann, Peter Kraft, Michael Bieber, Axel Haarmann, György A Homola, Mirko Pham, Bernhard Nieswandt, Guido Stoll
In acute ischemic stroke (AIS), there is an alarming discrepancy between recanalization rates of up to 70% by combined recombinant tissue-type plasminogen activator (rt-PA) therapy and mechanical thrombectomy, and no clinical benefit in at least every second stroke patient. This is partly due to ischemia/reperfusion (I/R) injury. In a translational approach, we used mice lacking dense- (Unc13d -/- ) or α-granules (Nbeal2 -/- ) and mice after blocking of platelet glycoprotein receptor (GP) Ib conferring protection from I/R injury...
January 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29322480/intra-operative-video-characterization-of-carotid-artery-pulsation-patterns-in-case-series-with-post-endarterectomy-hypertension-and-hyperperfusion-syndrome
#4
Yiming Xiao, Hassan Rivaz, Hidetoshi Kasuya, Suguru Yokosako, Cristina Mindru, Jeanne Teitelbaum, Denis Sirhan, David Sinclair, Mark Angle, Benjamin W Y Lo
Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of the condition is still unclear, making its prevention via prediction and monitoring challenging. This is especially true during surgery, when multiple factors can induce physiological changes, including blood pressure and baroreceptor functions, which are crucial factors for post-CEA hypertension and CHS...
January 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29322479/do-the-risk-factors-determine-the-severity-and-outcome-of-cerebral-venous-sinus-thrombosis
#5
Jayantee Kalita, Usha K Misra, Rajesh K Singh
We report the burden of risk factors in cerebral venous sinus thrombosis (CVST) and its relationship with the clinical severity, extent of MRI and MRV abnormality, and outcome. One hundred and twenty-eight consecutive patients with CVST were included. Their demographic, presenting symptoms and neurological findings were noted and risk factors of CVST were evaluated. The outcomes were assessed using modified Rankin Scale (mRS). Based on the risk factors, the patients could be categorized as prothrombotic conditions only in 46 (35...
January 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29318568/response-heroin-use-could-also-be-associated-with-ruptured-aortic-aneurysms
#6
EDITORIAL
Anil Can, Rose Du
No abstract text is available yet for this article.
January 9, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29313240/effect-of-ttc-treatment-on-immunohistochemical-quantification-of-collagen-iv-in-rat-brains-after-stroke
#7
Zhaojin Li, Nicole Bishop, Siu-Lung Chan, Marilyn J Cipolla
Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) would not interfere with collagen IV immunohistochemical staining compared with non-TTC-treated (TTC-) brain slices. We further hypothesized that there would be no difference in autofluorescence or nonspecific secondary antibody fluorescence between TTC+ and TTC- brain slices...
January 8, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29302794/evaluation-of-the-neuroprotective-effect-of-sirt3-in-experimental-stroke
#8
Rajkumar Verma, Rodney M Ritzel, Joshua Crapser, Brett D Friedler, Louise D McCullough
Sirtuins (Sirt) are a family of NAD+ dependent histone deacetylase (HDAC) proteins implicated in aging, cell cycle regulation, and metabolism. These proteins are involved in the epigenetic modification of neuromodulatory proteins after strokevia acetylation/deacetylation. The specific role of Sirt3, a mitochondrial sirtuin, in post-stroke injury has been relatively unexplored. Using male Sirt3 knockout (KO) mice and wild-type littermates (WT), we show that Sirt3 KO mice show significant neuroprotection at 3 days after ischemia/reperfusion (I/R) or stroke injury...
January 4, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29290003/inhibition-of-vegf-signaling-reduces-diabetes-exacerbated-brain-swelling-but-not-infarct-size-in-large-cerebral-infarction-in-mice
#9
Eunhee Kim, Jiwon Yang, Keun Woo Park, Sunghee Cho
In light of repeated translational failures with preclinical neuroprotection-based strategies, this preclinical study reevaluates brain swelling as an important pathological event in diabetic stroke and investigates underlying mechanism of the comorbidity-enhanced brain edema formation. Type 2 (mild), type 1 (moderate), and mixed type 1/2 (severe) diabetic mice were subjected to transient focal ischemia. Infarct volume, brain swelling, and IgG extravasation were assessed at 3 days post-stroke. Expression of vascular endothelial growth factor (VEGF)-A, endothelial-specific molecule-1 (Esm1), and the VEGF receptor 2 (VEGFR2) was determined in the ischemic brain...
December 30, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29285679/human-neural-stem-cell-extracellular-vesicles-improve-tissue-and-functional-recovery-in-the-murine-thromboembolic-stroke-model
#10
Robin L Webb, Erin E Kaiser, Shelley L Scoville, Tyler A Thompson, Sumbul Fatima, Chirayukumar Pandya, Karishma Sriram, Raymond L Swetenburg, Kumar Vaibhav, Ali S Arbab, Babak Baban, Krishnan M Dhandapani, David C Hess, M N Hoda, Steven L Stice
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in "young" rodent models and focusing on a single secondary injury mechanism. Here, extracellular vesicles (EVs), nanometer-sized cell signaling particles, were tested in a mouse thromboembolic (TE) stroke model. Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function...
December 28, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29282627/association-between-splenic-contraction-and-the-systemic-inflammatory-response-after-acute-ischemic-stroke-varies-with-age-and-race
#11
Alicia Zha, Farhaan Vahidy, Jaskaren Randhawa, Kaushik Parsha, Thanh Bui, Jaroslaw Aronowski, Sean I Savitz
Animal models have demonstrated the deleterious contribution of splenic immunocytes on secondary brain injury after stroke. While previous work has demonstrated splenic contraction (SC) in patients with acute ischemic stroke (AIS) and intracranial hemorrhage (ICH), no clinical studies have examined the relationship between the systemic inflammatory response syndrome (SIRS) with SC in stroke patients. This is a retrospective analysis of a previous prospective observational study where daily spleen sizes were evaluated in 178 acute stroke patients...
December 27, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29275501/baicalin-attenuates-blood-brain-barrier-disruption-and-hemorrhagic-transformation-and-improves-neurological-outcome-in-ischemic-stroke-rats-with-delayed-t-pa-treatment-involvement-of-onoo-mmp-9-pathway
#12
Hansen Chen, Binghe Guan, Xi Chen, Xingmiao Chen, Caiming Li, Jinhua Qiu, Dan Yang, Ke Jian Liu, Suhua Qi, Jiangang Shen
Tissue plasminogen activator (t-PA) has a restrictive therapeutic window within 4.5 h after ischemic stroke with the risk of hemorrhagic transformation (HT) and neurotoxicity when it is used beyond the time window. In the present study, we tested the hypothesis that baicalin, an active compound of medicinal plant, could attenuate HT in cerebral ischemia stroke with delayed t-PA treatment. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 4.5 h and then continuously received t-PA infusion (10 mg/kg) for 0...
December 23, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29243025/heroin-use-could-be-also-associated-with-ruptured-aortic-aneurysms
#13
LETTER
Tung-Ho Wu, Hsing-Lin Lin
No abstract text is available yet for this article.
December 15, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29224114/coated-platelet-trends-predict-short-term-clinical-outcomeafter-subarachnoid-hemorrhage
#14
Bappaditya Ray, Vijay M Pandav, Eleanor A Mathews, David M Thompson, Lance Ford, Lori K Yearout, Bradley N Bohnstedt, Shuchi Chaudhary, George L Dale, Calin I Prodan
Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high socio-economic burden. Prothrombotic states of early brain injury (EBI) and delayed cerebral ischemia (DCI) after aSAH determine morbidity and mortality. To understand how activated platelets might contribute to such prothrombotic states, we studied trends in coated-platelets during EBI and DCI periods. Serial blood samples from a prospective cohort of aSAH patients were collected and assayed for coated-platelet levels. Patient's coated-platelet level during post-hospital discharge follow-up served as an estimate of baseline...
December 9, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29218547/expression-of-class-i%C3%A2-histone-deacetylases-in-ipsilateral-and-contralateral-hemispheres-after-the-focal-photothrombotic-infarction-in-the-mouse-brain
#15
Svetlana Demyanenko, Maria Neginskaya, Elena Berezhnaya
Histone acetylation and deacetylation are among the most important epigenetic processes that regulate gene expression. Nonselective inhibitors of histone deacetylases (HDAC) can protect brain cells during ischemia and stroke. However, which HDAC isoform is involved in this effect is unknown. Some isoforms of histone deacetylases (HDACs) protect brain cells after ischemia, whereas others can promote their death. Most studies consider early periods (1-24 h) after stroke, whereas little is known on the involvement of HDACs during recovery after stroke...
December 7, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29196884/ultrasonographical-features-associated-with-progression-of-atherosclerosis-in-patients-with-moderate-internal-carotid-artery-stenosis
#16
Yumei Liu, Yang Hua, Ran Liu, Lili Wang, Chun Duan, Chen Ling, Xiaoguang Wu, Ovbiagele Bruce, Wuwei Feng
Carotid artery stenosis (CAS) is a leading cause of ischemic stroke. Plaque stabilization is a major management approach. Information about the ultrasonographical and clinical features associated with the progression of moderate internal carotid artery (ICA) stenosis (50-69%) could assist with prognostication and risk factor modifications. We evaluated 287 patients with moderate ICA stenosis (50-69%) and subsequently evaluated them at follow-up points at 12, 24, and 36 months. Patients were divided into three groups according to the degree of ICA stenosis: progression (70-99%, n = 48), stable (50-69%, n = 210), and regression (< 50%, n = 29)...
December 1, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29188434/photothrombotic-stroke-as-a-model-of-ischemic-stroke
#17
REVIEW
Anatoly B Uzdensky
The search of effective anti-stroke neuroprotectors requires various stroke models adequate for different aspects of the ischemic processes. The photothrombotic stroke model is particularly suitable for the study of cellular and molecular mechanisms underlying neurodegeneration, neuroprotection, and neuroregeneration. It is a model of occlusion of small cerebral vessels, which provides detailed study of molecular mechanisms of ischemic cell death and useful for search of potential anti-stroke agents. Its advantages include well-defined location and size of ischemic lesion that are determined by the aiming of the laser beam at the predetermined brain region; easy impact dosing by changing light intensity and duration; low invasiveness and minimal surgical intervention without craniotomy and mechanical manipulations with blood vessel, which carry the risk of brain trauma; low animal mortality and prolonged sensorimotor impairment that provide long-term study of stroke consequences including behavior impairment and recovery; independence on genetic variations of blood pressure and vascular architecture; and high reproducibility...
November 29, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29177991/correction-to-treatment-with-the-ppar%C3%AE-agonist-pioglitazone-in-the-early-post-ischemia-phase-inhibits-pro-inflammatory-responses-and-promotes-neurogenesis-via-the-activation-of-innate-and-bone-marrow-derived-stem-cells-in-rats
#18
Tomoya Kinouchi, Keiko T Kitazato, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Nobuhisa Matsushita, Yoshitaka Kurashiki, Junichiro Satomi, Masataka Sata, Shinji Nagahiro
In the original publication of the article, the second author (Keiko T. Kitazato) was missing.
November 26, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29178027/mri-guiding-of-the-middle-cerebral-artery-occlusion-in-rats-aimed-to-improve-stroke-modeling
#19
Ilya L Gubskiy, Daria D Namestnikova, Elvira A Cherkashova, Vladimir P Chekhonin, Vladimir P Baklaushev, Leonid V Gubsky, Konstantin N Yarygin
The middle cerebral artery occlusion (MCAO) model in rats closely imitates ischemic stroke and is widely used. Existing instrumental methods provide a certain level of MCAO guidance, but monitoring of the MCA-occluding intraluminal filament position and possible complications can be improved. The goal of this study was to develop a MRI-based method of simultaneous control of the filament position, blood flow in the intracranial vessels, and hemorrhagic complications. Rats were subjected to either MRI-guided MCAO (group 1, n = 51) or MCAO without MRI control (group 2, n = 38)...
November 25, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29177950/vascular-and-tissue-changes-of-magnetic-susceptibility-in-the-mouse-brain-after-transient-cerebral-ischemia
#20
Markus Vaas, Andreas Deistung, Jürgen R Reichenbach, Annika Keller, Anja Kipar, Jan Klohs
Quantitative susceptibility mapping (QSM) has been recently introduced as a novel MRI post-processing technique of gradient recalled echo (GRE) data. QSM is useful in depicting both brain anatomy and for detecting abnormalities. Its utility in the context of ischemic stroke has, however, not been extensively characterized so far. In this study, we explored the potential of QSM to characterize vascular and tissue changes in the transient middle cerebral artery occlusion (tMCAO) mouse model of cerebral ischemia...
November 25, 2017: Translational Stroke Research
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