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Research in Pharmaceutical Sciences

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https://www.readbyqxmd.com/read/29853937/the-effect-of-different-coating-materials-on-the-prevention-of-powder-bounce-in-the-next-generation-impactor
#1
Shadi Farshbaf Khalili, Saeed Ghanbarzadeh, Ali Nokhodchi, Hamed Hamishehkar
In the process of quality control of pulmonary drug delivery products, aerosolization efficiency is mainly determined using impactors, e.g. next generation impactor (NGI). However, particle bounce may interfere with the validity and accuracy of results due to the overestimation of the respirable fraction. It is suggested that the coating of impactor's stages may prevent the particle bounce. Therefore, coating materials may influence the results of the aerosolization indexes of pulmonary dosage forms. The aim of this study was to investigate if the aerosolization indices are affected differently by using the different coating materials...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853936/preparation-process-optimization-and-characterization-of-core-shell-polyurethane-chitosan-nanofibers-as-a-potential-platform-for-bioactive-scaffolds
#2
Laleh Maleknia, Mandana Dilamian, Mohammad Kazemi Pilehrood, Hojjat Sadeghi-Aliabadi, Amir Houshang Hekmati
In this paper, polyurethane (PU), chitosan (Cs)/polyethylene oxide (PEO), and core-shell PU/Cs nanofibers were produced at the optimal processing conditions using electrospinning technique. Several methods including SEM, TEM, FTIR, XRD, DSC, TGA and image analysis were utilized to characterize these nanofibrous structures. SEM images exhibited that the core-shell PU/Cs nanofibers were spun without any structural imperfections at the optimized processing conditions. TEM image confirmed the PU/Cs core-shell nanofibers were formed apparently...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853935/synthesis-and-evaluation-of-anticonvulsant-activity-of-z-4-2-oxoindolin-3-ylideneamino-n-phenylbenzamide-derivatives-in-mice
#3
Marzieh Rahmani Khajouei, Ahmad Mohammadi-Farani, Aref Moradi, Alireza Aliabadi
Due to resistance of some epileptic patients to the current medications and the general incidence of severe side effects of these drugs, development and discovery of novel antiepileptic drugs is crucial. Isatin-based derivatives are promising compounds as antiepileptic agents. In this study a new series of isatin-containing derivatives were synthesized via the imine formation between isatin and p -aminobenzoic acid. Subsequently, the obtained acidic compound was utilized to prepare the final amidic derivatives ( 4a-4l ) through the reaction with various aniline derivatives...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853934/development-physicochemical-characterization-and-antimicrobial-evaluation-of-niosomal-myrtle-essential-oil
#4
Mahboobeh Raeiszadeh, Abbas Pardakhty, Fariba Sharififar, Alireza Farsinejad, Mehrnaz Mehrabani, Hossein Hosseini-Nave, Mitra Mehrabani
Myrtus communis (myrtle) is well known for its therapeutic effects pertaining to the major secondary metabolites including essential oils (EOs). EOs are composed of volatile compounds and simply evaporate or decompose leading to their instability. Preparation of EOs niosomal formulation may be a promising approach to deal with these obstacles. Niosomal formulations of myrtle essential oil (nMEO) were provided using non-ionic surfactants and cholesterol (Chol). In the next steps, vesicle size, zeta potential, percentage of entrapment efficiency (EE%) and physical stability of nMEO were investigated...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853933/a-study-on-opg-rank-rankl-axis-in-osteoporotic-bile-duct-ligated-rats-and-the-involvement-of-nitrergic-and-opioidergic-systems
#5
Amir Hossein Doustimotlagh, Ahmad Reza Dehpour, Shahroo Etemad-Moghadam, Mojgan Alaeddini, Sattar Ostadhadi, Abolfazl Golestani
Chronic liver disease (CLD) affects millions of people and its impact on bone loss has become a subject of interest. Nitric oxide and endogenous opioids are suggested to increase during cholestasis/cirrhosis and may impact bone resorption by different mechanisms. The receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL)/osteoprotegerin (OPG) signaling pathway regulates bone resorption, but its role in metabolic bone disease subsequent to CLD is unknown. We aimed to investigate the involvement of nitrergic and opioidergic systems in bone loss relative to the RANK/RANKL/OPG pathway, in bile duct-ligated (BDL) rats...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853932/bioprocess-and-downstream-optimization-of-recombinant-human-growth-hormone-in-pichia-pastoris
#6
Saeed Azadi, Seyed Kazem Sadjady, Seyed Alireza Mortazavi, Nasser Naghdi, Arash Mahboubi, Roya Solaimanian
The methylotrophic yeast Pichia pastoris is a well-established expression host, which is often used in the production of protein pharmaceuticals. This work aimed to evaluate the effect of various concentrations of ascorbic acid in mixed feeding strategy with sorbitol/methanol on productivity of recombinant human growth hormone (r-hGH). The relevant concentration of ascorbic acid (5, 10, or 20 mmol) and 50 g/L sorbitol were added in batch-wise mode to the medium at the beginning of induction phase. The rate of methanol addition was increased stepwise during the first 12 h of production and then kept constant...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853931/synthesis-antimicrobial-evaluation-and-docking-studies-of-some-novel-quinazolinone-schiff-base-derivatives
#7
Rezvan Rezaee Nasab, Mahboubeh Mansourian, Farshid Hassanzadeh
The quinazolin-4(3H)-one structural motif possesses a wide spectrum of biological activities. DNA gyrase play an important role in induction of bacterial death. It has been shown that many quinazolin-4(3H)-one derivatives have antibacterial effects through inhibition of DNA gyrase. Based on this information we decided to synthesize novel quinazolinone Schiff base derivatives in order to evaluate their antibacterial effects. A series of novel quinazolinone Schiff base derivatives were designed and synthesized from benzoic acid...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853930/anxiolytic-effects-of-lippia-citriodora-in-a-mouce-model-of-anxiety
#8
Atousa Bonyani, Seyed Ebrahim Sajjadi, Mohammad Rabbani
Lippia citriodora is commonly used in Iranian folk medicine for treatment of many disorders. Since there scientific data to prove the anxiolytic properties of this plant in Iran are scarce, we aimed to evaluate the sedative and anxiolytic activity of the leaf extract and essence of L. citriodora in an animal model of anxiety. The extract and the essence used were obtained after maceration and hydro-distillation of the leaves of L. citriodora , respectively. We evaluated the anti-anxiety profile and sedative activity of diazepam (1 mg/kg i...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853929/probing-the-chemical-interaction-space-governed-by-4-aminosubstituted-benzenesulfonamides-and-carbonic-anhydrase-isoforms
#9
Behnam Rasti, Yeganeh Entezari Heravi
Isoform diversity, critical physiological roles and involvement in major diseases/disorders such as glaucoma, epilepsy, Alzheimer's disease, obesity, and cancers have made carbonic anhydrase (CA), one of the most interesting case studies in the field of computer aided drug design. Since applying non-selective inhibitors can result in major side effects, there have been considerable efforts so far to achieve selective inhibitors for different isoforms of CA. Using proteochemometrics approach, the chemical interaction space governed by a group of 4-amino-substituted benzenesulfonamides and human CAs has been explored in the present study...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29853928/preparation-and-characterization-of-an-injectable-thermosensitive-hydrogel-for-simultaneous-delivery-of-paclitaxel-and-doxorubicin
#10
Mahboubeh Rezazadeh, Vajihe Akbari, Elham Amuaghae, Jaber Emami
In the current study, we aimed to develop a novel injectable thermosensitive hydrogel for simultaneous intra-tumoral administration of paclitaxel (PTX) and doxorubicin hydrochloride (DOX). At first, mixed micelles composed of Pluronic F127 and α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was loaded with PTX and their physicochemical properties including particle size, zeta potential, drug loading content, entrapment efficiency, and the drug release were investigated in details. In the second step, the optimized PTX-loaded micelles prepared in the first step were incorporated into the thermosensitive Pluronic F127/hyaluronic acid (PF127/HA) hydrogel containing fixed amount of DOX...
June 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606972/renal-vascular-response-to-angiotensin-1-7-in-rats-the-role-of-mas-receptor
#11
Mehdi Nematbakhsh, Azam Mansouri
Recently a cross talk between angiotensin 1-7 (Ang1-7) receptor (MasR) and angiotensin II receptors types 1 and 2 (AT1R and AT2R) has been highlighted. The effects of MasR antagonist (A779) compared to the vehicle on the renal blood flow (RBF) and renal vascular resistance (RVR) responses to Ang1-7 (300 ng/kg/min) infusion in the absence of Ang II receptors in male and female rats were determined at controlled renal perfusion pressure. Ang1-7 infusion did not alter mean arterial pressure in male and female rats...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606971/synthesis-and-cytotoxic-evaluation-of-some-novel-quinoxalinedione-diarylamide-sorafenib-analogues
#12
Mojtaba Khandan, Sedighe Sadeghian-Rizi, Ghadamali Khodarahmi, Farshid Hassanzadeh
A series of novel sorafenib analogues containing a quinoxalinedione ring and amide linker were synthesized. A total of 9 novel compounds in 6 synthetic steps were synthesized. Briefly, the amino group of p-aminophenol was first protected which then followed by O-arylation with 5-chloro-2-nitroaniline to provide compound d . Reduction of the nitro group of compound d and cyclization of the diamine group of compound e with oxalic acid afforded compound f which on deacetylation yeilded compound g . Then compound g was reacted with different acyl halides to afford the target compounds 1h-1p ...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606970/the-protective-role-of-melatonin-in-cadmium-induced-proliferation-of-ovarian-cancer-cells
#13
Negar Ataei, Mahmoud Aghaei, Mojtaba Panjehpour
Cadmium (Cd), a ubiquitous environmental and occupational pollutant, acts as a metalloestrogen to induce cell proliferation. It is suggested that Cd may also contribute to the development of estrogen-related cancers like ovarian cancer which is the most lethal cancer in women. Furthermore, it was shown that melatonin has antiproliferative effect on estradiol (E2)-induced proliferation. The aim of the present study was to evaluate whether melatonin inhibits Cd-induced proliferation in ovarian cancer cell lines and also whether Cd and melatonin can modulate estrogen receptor α (ERα) expression...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606969/bioassay-directed-isolation-of-quaternary-benzylisoquinolines-from-berberis-integerrima-with-bactericidal-activity-against-brucella-abortus
#14
Gholamhassan Azimi, Ali Hakakian, Mustafa Ghanadian, Ali Joumaa, Saeed Alamian
Berberis integerrima Bonge. (Syn: Berberis densiflora Boiss. & Buhse) is a shrub widely distributed in Middle East and central part of Asia. An ethnobotanical study revealed that indigenous and tribal people in Iran use B. integerrima root decoction for treatment of brucellosis. Therefore, the aim of this study was bioassay directed isolation of antibacterial compounds from this plant based on their in vitro bactericidal activity against Brucella abortus . Briefly, the ethanol extract of B. integerrima was fractioned and subjected to preliminary antibacterial screening tests against Brucella...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606968/the-effect-of-betulinic-acid-on-leptin-adiponectin-hepatic-enzyme-levels-and-lipid-profiles-in-streptozotocin-nicotinamide-induced-diabetic-mice
#15
Akram Ahangarpour, Razieh Shabani, Yaghoob Farbood
Diabetes mellitus is developed by lack of insulin secretion or reduction of tissues sensitivity to insulin, which lead to serious complications. The aim of this study is to evaluate antihyperlipidemic effect of betulinic acid (BA) on streptozotocin-nicotinamide (STZ-NA) induced diabetic mice. In this experimental study, seventy adult male NMRI mice (20-25 g) were divided randomly into seven groups ( n = 10) of control, sham, diabetes, diabetes + BA (10, 20 and 40 mg/kg), and diabetes + metformin (200 mg/kg)...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606967/effects-of-oregano-essential-oil-on-brain-tlr4-and-tlr2-gene-expression-and-depressive-like-behavior-in-a-rat-model
#16
Azam Amiresmaeili, Samira Roohollahi, Ali Mostafavi, Nayere Askari
The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS). Sucrose preference and forced swim tests were adopted to examine the antidepressant effect. Control (CON), OEO, CUS, and CUS + OEO groups were used. The OEO and CUS + OEO groups received OEO (0.2 mL/kg, i.p.), CON and CUS received saline (0.2 mL/kg, i.p.), and the positive drug groups of CUS rats received fluoxetine (10 mg/kg) and diazepam (3 mg/kg) once daily for 14 days...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606966/protective-effects-of-glucosamine-and-its-acetylated-derivative-on-serum-glucose-deprivation-induced-pc12-cells-death-role-of-reactive-oxygen-species
#17
Seyed Hadi Mousavi, Elham Bakhtiari, Azar Hosseini, Khadijeh Jamialahmadi
Finding products with antiapoptotic activities has been one of the approaches for the treatment of neurodegenerative disorders. Serum/glucose deprivation (SGD) has been used as a model for the investigation of the molecular mechanisms of neuronal ischemia. Recent studies indicated that glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) have many pharmacological effects including antioxidant activities. The present study aimed to investigate the protective effects of GlcN and GlcNAc against SGD-induced PC12 cells injury...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606965/synthesis-and-antileishmanial-activity-of-antimony-v-complexes-of-hydroxypyranone-and-hydroxypyridinone-ligands
#18
Vafa Sheikhmoradi, Sedigheh Saberi, Lotfollah Saghaei, Nader Pestehchian, Afshin Fassihi
A novel series of antimony (V) complexes with the hydroxypyranone and hydroxypyridinone ligands were synthesized and characterized by 1 HNMR, FT-IR and electron spin ionization mass spectroscopic (ESI-MS) techniques. The synthesis process involved protection of hydroxyl group followed by the reaction of the intermediate with primary amines and finally deprotection. All compounds were evaluated for in vitro activities against the amastigote and promastigote forms of Leishmania major . Most of the synthesized compounds exhibited good antileishmanial activity against both forms of L...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606964/the-immunoinhibitory-and-apoptosis-inducing-activities-of-foeniculum-vulgare-on-human-peripheral-blood-lymphocytes
#19
Salimeh Ebrahimnezhad Darzi, Seyedeh Parvin Khazraei, Zahra Amirghofran
Foeniculum vulgare ( F. vulgare, Apiaceae) is an important plant currently used in folk medicine to treat various diseases including infections and inflammatory conditions. In this study we have investigated the immunomodulatory and apoptosis-inducing activities of the fractions from this plant. We prepared dichloromethane, hexane, butanol, and water fractions from the aerial parts of the plant. We examined the growth inhibitory effects of the fractions on proliferative lymphocytes by the BrdU incorporation assay...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29606963/synthesis-characterization-and-stability-study-of-desloratadine-multicomponent-crystal-formation
#20
Ahmad Ainurofiq, Rachmat Mauludin, Diky Mudhakir, Sundani Nurono Soewandhi
This study describes the formation of multicomponent crystal (MCC) of desloratadine (DES). The objective of this study was to discover the new pharmaceutical MCC of DES using several coformers. The MCC synthesis was performed between DES and 26 coformers using an equimolar ratio with a solvent evaporation technique. The selection of the appropriate solvent was carried out using 12 solvents. The preview of the MCC of DES was performed using polarized light microscopy (PLM). The formation of MCC was confirmed using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM)...
April 2018: Research in Pharmaceutical Sciences
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