journal
https://read.qxmd.com/read/34046148/value-added-by-an-inter-continental-cancer-consortium
#21
EDITORIAL
Mahadev Rao, Prasanna Venkatraman, Debabrata Mukhopadhyay, Susanta Roychoudhury, Nathan L Vanderford, Vivek M Rangnekar
No abstract text is available yet for this article.
2021: Genes & Cancer
https://read.qxmd.com/read/33884106/immunotherapy-of-prostate-cancer-using-novel-synthetic-dna-vaccines-targeting-multiple-tumor-antigens
#22
JOURNAL ARTICLE
Devivasha Bordoloi, Peng Xiao, Hyeree Choi, Michelle Ho, Alfredo Perales-Puchalt, Makan Khoshnejad, J Joseph Kim, Laurent Humeau, Alagarsamy Srinivasan, David B Weiner, Kar Muthumani
Prostate cancer is a prevalent cancer in men and consists of both indolent and aggressive phenotypes. While active surveillance is recommended for the former, current treatments for the latter include surgery, radiation, chemo and hormonal therapy. It has been observed that the recurrence in the treated patients is high and results in castration resistant prostate cancer for which treatment options are limited. This scenario has prompted us to consider immunotherapy with synthetic DNA vaccines, as this approach can generate antigen-specific tumor-killing immune cells...
2021: Genes & Cancer
https://read.qxmd.com/read/33884105/are-molecular-tests-necessary-to-diagnose-niftp
#23
JOURNAL ARTICLE
Artur Kuchareczko, Janusz Kopczyński, Artur Kowalik, Kinga Hińcza, Agnieszka Płusa, Stanisław Góźdź, Aldona Kowalska
In 2016, encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). In 2018 the criteria for NIFTP were widened by the inclusion of the complete lack of papillae. Secondary criteria, which include molecular examination, are helpful but not required for NIFTP diagnose. The aim of this study was to assess the molecular background of NIFTP and to answer the question if the aplication of revised criteria for NIFTP diagnosis is associated with the lack of oncogenic mutation...
2021: Genes & Cancer
https://read.qxmd.com/read/33884104/prophylactic-cranial-irradiation-reduces-the-incidence-of-brain-metastasis-in-a-mouse-model-of-metastatic-her2-positive-breast-cancer
#24
JOURNAL ARTICLE
Daniel L Smith, Bisrat G Debeb, Parmeswaran Diagaradjane, Richard Larson, Swaminathan Kumar, Jing Ning, Lara Lacerda, Li Li, Wendy A Woodward
Prophylactic cranial irradiation (PCI) can reduce the incidence of brain metastasis and improve overall survival in some patients with acute lymphoblastic leukemia or small-cell lung cancer. We examined the potential effects of PCI in a mouse model of breast cancer brain metastasis. The HER2+ inflammatory breast cancer cell line MDA-IBC3 was labeled with green fluorescent protein and injected via tail-vein into female SCID/Beige mice. Mice were then given 0 Gy or 4 Gy of whole-brain irradiation 2 days before tumor-cell injection or 5 days, 3 weeks, or 6 weeks after tumor-cell injection...
2021: Genes & Cancer
https://read.qxmd.com/read/33884103/correction-cdk4-6-inhibition-provides-a-potent-adjunct-to-her2-targeted-therapies-in-preclinical-breast-cancer-models
#25
Agnieszka K Witkiewicz, Derek Cox, Erik S Knudsen
[This corrects the article DOI: 10.18632/genesandcancer.24.].
2021: Genes & Cancer
https://read.qxmd.com/read/33884102/key-drug-targeting-genes-in-pancreatic-ductal-adenocarcinoma
#26
JOURNAL ARTICLE
Meena Kishore Sakharkar, Sarinder Kaur Dhillon, Mohit Mazumder, Jian Yang
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal type of cancer. In this study, we undertook a pairwise comparison of gene expression pattern between tumor tissue and its matching adjacent normal tissue for 45 PDAC patients and identified 22 upregulated and 32 downregulated genes. PPI network revealed that fibronectin 1 and serpin peptidase inhibitor B5 were the most interconnected upregulated-nodes. Virtual screening identified bleomycin exhibited reasonably strong binding to both proteins. Effect of bleomycin on cell viability was examined against two PDAC cell lines, AsPC-1 and MIA PaCa-2...
2021: Genes & Cancer
https://read.qxmd.com/read/33868579/gene-signatures-of-cyclin-dependent-kinases-a-comparative-study-in-na%C3%A3-ve-early-and-advanced-stages-of-lung-metastasis-breast-cancer-among-pre-and-post-menopausal-women
#27
JOURNAL ARTICLE
Muhammad Fazal Hussain Qureshi, Muzna Shah, Mahira Lakhani, Zain Jawed Abubaker, Danish Mohammad, Hira Farhan, Iman Zia, Rida Tafveez, Samahir Tariq Khan, Ghani Rubina, Mushtaq Shamim, Haider Ghulam
The Human epidermal growth factor receptor 2 positive (HER2+) breast cancer (BC) is a more aggressive tumor with 5 years median survival rates after metastasis. Despite successful treatment, unfortunately, the majority of affected patients die. Defects in cell cycle and transcription regulation phases which are governed by cyclin-dependent kinases (CDKs) are the hallmark of many cancers that underpinning the progression of the disease. Therefore, the current study looked at the alteration of six CDKs mRNA expression levels in pre- and postmenopausal lung metastasis BC groups; the majority were HER2+...
2021: Genes & Cancer
https://read.qxmd.com/read/33488952/autophagy-is-associated-with-a-robust-specific-transcriptional-signature-in-breast-cancer-subtypes
#28
JOURNAL ARTICLE
Céline Grandvallet, Jean Paul Feugeas, Franck Monnien, Gilles Despouy, Perez Valérie, Guittaut Michaël, Eric Hervouet, Paul Peixoto
Previous works have described that autophagy could be associated to both pro- and anti-cancer properties according to numerous factors, such as the gene considered, the step of autophagy involved or the cancer model used. These data might be explained by the fact that some autophagy-related genes may be involved in other cellular processes and therefore differently regulated according to the type or the grade of the tumor. Indeed, using different approaches of transcriptome analysis in breast cancers, and further confirmation using digital PCR, we identified a specific signature of autophagy gene expression associated to Luminal A or Triple Negative Breast Cancers (TNBC)...
December 31, 2020: Genes & Cancer
https://read.qxmd.com/read/33488951/variant-profiles-of-genes-mapping-to-chromosome-16q-loss-in-wilms-tumors-reveals-link-to-cilia-related-genes-and-pathways
#29
JOURNAL ARTICLE
Eiko Kitamura, John K Cowell, Chang-Sheng Chang, Lesleyann Hawthorn
BACKGROUND: Wilms tumor is the most common pediatric renal tumor and the fourth most common malignancy in children. Chromosome 16q deletion(del) or loss of heterozygosity (LOH) has been correlated with recurrence and overall poor prognosis, such that patients with 16qLOH and 1p allelic loss are treated with more aggressive chemotherapeutic regimens. METHODS: In the present study, we have compared the variant profiles of Wilms tumors with and without 16q del/LOH using both data available from the TARGET database (42 samples) and tumors procured from our legacy collection (8 samples)...
December 31, 2020: Genes & Cancer
https://read.qxmd.com/read/33488950/oncogenes-in-high-grade-serous-adenocarcinoma-of-the-ovary
#30
JOURNAL ARTICLE
Pacharla Manasa, Chirukandath Sidhanth, Syama Krishnapriya, Sekar Vasudevan, Trivadi S Ganesan
High grade serous ovarian cancer is characterized by relatively few mutations occurring at low frequency, except in TP53. However other genetic aberrations such as copy number variation alter numerous oncogenes and tumor suppressor genes. Oncogenes are positive regulators of tumorigenesis and play a critical role in cancer cell growth, proliferation, and survival. Accumulating evidence suggests that they are crucial for the development and the progression of high grade serous ovarian carcinoma (HGSOC). Though many oncogenes have been identified, no successful inhibitors targeting these molecules and their associated pathways are available...
December 31, 2020: Genes & Cancer
https://read.qxmd.com/read/33488949/multi-kinase-targeted-therapy-as-a-promising-treatment-strategy-for-ovarian-tumors-expressing-sfron-receptor
#31
JOURNAL ARTICLE
Luyao Wang, Lin Wang, Magdalena Cybula, Ana Luiza Drumond-Bock, Katherine M Moxley, Magdalena Bieniasz
The sfRon kinase is an important therapeutic target in ovarian cancer that contributes to prominent tumor growth and disease progression. We reasoned that a multi-kinase inhibition of sfRon pathway might be an effective strategy to achieve a sustained anti-tumor response, while simultaneously preventing treatment resistance. We performed a detailed dissection of sfRon signaling in vitro and demonstrated that S6K1 is a key component of a multi-kinase targeting strategy in sfRon expressing ovarian tumors. We selected AD80 compound that targets several kinases within sfRon pathway including AKT and S6K1, and compared its efficacy with inhibitors that selectively target either sfRon or PI3 kinase...
December 31, 2020: Genes & Cancer
https://read.qxmd.com/read/33488948/novel-strategies-to-target-chemoresistant-triple-negative-breast-cancer
#32
JOURNAL ARTICLE
Jaganathan Venkatesh, Arun K Rishi, Kaladhar B Reddy
Previous studies from our group and others have shown that current drug treatment(s) strategies eliminate bulk of tumor cells (non-CSCs) but it had a minimal effect on cancer stem cells (CSCs) leading to resistance and tumor recurrence. We studied the effects of CFM-4.16 (CARP-1 functional mimetic) and/or cisplatin on four Triple-negative breast cancer (TNBC) MDA-MB-468, MDA-MB-231, CRL-2335 and BR-1126, two cisplatin resistant CisR/MDA-231 and CisR/MDA-468 and cancer stem cells (CSCs) from resistant cell lines...
December 31, 2020: Genes & Cancer
https://read.qxmd.com/read/32577159/loss-of-trp53-p53-accelerates-tumorigenesis-and-changes-the-tumor-spectrum-of-sjl-j-mice
#33
JOURNAL ARTICLE
Jane A Branca, Benjamin E Low, Ruth L Saxl, Jennifer K Sargent, Rosalinda A Doty, Michael V Wiles, Beth L Dumont, Muneer G Hasham
Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background-SJL/J mice. The absence of TRP53 (TRP53 nullizygosity) leads to a shift in the tumor spectrum from a non-Hodgkin's-like disease to thymic lymphomas and testicular teratomas at a very rapid tumor onset averaging ~12 weeks of age. In haplotype studies, comparing tumor prone versus tumor resistant Trp53 null mouse strains, we found that other tumor suppressor, DNA repair and/or immune system genes modulate tumor incidence in TRP53 null strains, suggesting that even a strong tumor suppressor such as TRP53 is modulated by genetic background...
2020: Genes & Cancer
https://read.qxmd.com/read/32577158/fatty-changes-associated-with-n-nitrosodiethylamine-den-induced-hepatocellular-carcinoma-a-role-of-sonic-hedgehog-signaling-pathway
#34
JOURNAL ARTICLE
Anindita Tripathy, Sudhir Thakurela, Manoj Kumar Sahu, Kanishka Uthansingh, Ayaskanta Singh, Jimmy Narayan, Amrendra Kumar Ajay, Vinay Singh, Ratna Kumari
BACKGROUNDS AND AIMS: Hepatocellular Carcinoma (HCC) is the leading cause of cancer-related mortality across the world. Non-viral etiological factors including obesity and metabolic syndrome have now become prevalent cause of hepatocellular carcinoma. Sonic Hedgehog (SHH) pathway is activated in hepatocellular carcinoma but its role in regulation of lipogenic molecules during the hepatocarcinogenesis is not known. The aim of present study is to explore the role of SHH pathway in fatty changes associated with hepatocarcinogenesis at different stages and to further correlate the expression of SHH with lipogenic pathways...
2020: Genes & Cancer
https://read.qxmd.com/read/32577157/kdm3a-ets1-mcam-axis-promotes-growth-and-metastatic-properties-in-rhabdomyosarcoma
#35
JOURNAL ARTICLE
Lays Martin Sobral, Marybeth Sechler, Janet K Parrish, Tyler S McCann, Kenneth L Jones, Joshua C Black, Paul Jedlicka
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy of childhood. RMS exists as two major disease subtypes, with oncofusion-positive RMS (FP-RMS) typically carrying a worse prognosis than oncofusion-negative RMS (FN-RMS), in part due to higher propensity for metastasis. Epigenetic mechanisms have recently emerged as critical players in the pathogenesis of pediatric cancers, as well as potential new therapeutic vulnerabilities. Herein, we show that the epigenetic regulator KDM3A, a member of the Jumonji-domain histone demethylase (JHDM) family, is overexpressed, potently promotes colony formation and transendothelial invasion, and activates the expression of genes involved in cell growth, migration and metastasis, in both FN-RMS and FP-RMS...
2020: Genes & Cancer
https://read.qxmd.com/read/32577156/alterations-in-tgf-%C3%AE-signaling-leads-to-high-hmga2-levels-potentially-through-modulation-of-pja1-smad3-in-hcc-cells
#36
JOURNAL ARTICLE
Kazufumi Ohshiro, Jian Chen, Jigisha Srivastav, Lopa Mishra, Bibhuti Mishra
Recently, we observed that the TGF-β pathway is altered in 39% of HCCs. The alterations are correlated with a raised HMGA2 level. Therefore, we compared genetic alterations of HMGA2 and 43 TGF-β pathway core genes in HCC patients from TCGA database. Genetic alterations of 15 genes, including INHBE, INHBC, GDF11, ACVRL and TGFB2 out of 43 core genes, highly-moderately matched that of HMGA2. Co-occurrences of mutation amplification, gains, deletions and high/low mRNA of HMGA2 with those of the core genes were highly significant in INHBE, INHBC, ACVR1B, ACVRL and GDF11...
2020: Genes & Cancer
https://read.qxmd.com/read/32577155/micrornas-targeting-cellular-cholesterol-implications-for-combating-anticancer-drug-resistance
#37
JOURNAL ARTICLE
Bernice Monchusi, Mandeep Kaur
Over sixty percent of all mammalian protein-coding genes are estimated to be regulated by microRNAs (miRNAs), and unsurprisingly miRNA dysregulation has been linked with cancer. Aberrant miRNA expression in cancer cells has been linked with tumourigenesis and drug resistance. In the past decade, increasing number of studies have demonstrated that cholesterol accumulation fuels tumour growth and contributes to drug resistance, therefore, miRNAs controlling cholesterol metabolism and homeostasis are obvious hypothetical targets for investigating their role in cholesterol-mediated drug resistance in cancer...
2020: Genes & Cancer
https://read.qxmd.com/read/32577154/non-circadian-aspects-of-bhlhe40-cellular-function-in-cancer
#38
JOURNAL ARTICLE
Zsofia Kiss, Maria Mudryj, Paramita M Ghosh
While many genes specifically act as oncogenes or tumor suppressors, others are tumor promoters or suppressors in a context-dependent manner. Here we will review the basic-helix-loop-helix (BHLH) protein BHLHE40, (also known as BHLHB2, STRA13, DEC1, or SHARP2) which is overexpressed in gastric, breast, and brain tumors; and downregulated in colorectal, esophageal, pancreatic and lung cancer. As a transcription factor, BHLHE40 is expressed in the nucleus, where it binds to target gene promoters containing the E-box hexanucleotide sequence, but can also be expressed in the cytoplasm, where it stabilizes cyclin E, preventing cyclin E-mediated DNA replication and cell cycle progression...
2020: Genes & Cancer
https://read.qxmd.com/read/31258835/dissecting-the-expression-landscape-of-cytochromes-p450-in-hepatocellular-carcinoma-towards-novel-molecular-biomarkers
#39
JOURNAL ARTICLE
Camille Martenon Brodeur, Philippe Thibault, Mathieu Durand, Jean-Pierre Perreault, Martin Bisaillon
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths around the world. Recent advances in genomic technologies have allowed the identification of various molecular signatures in HCC tissues. For instance, differential gene expression levels of various cytochrome P450 genes (CYP450) have been reported in studies performed on limited numbers of HCC tissue samples, or focused on a small subset on CYP450s. In the present study, we monitored the expression landscape of all the members of the CYP450 family (57 genes) in more than 200 HCC tissues using RNA-Seq data from The Cancer Genome Atlas...
May 2019: Genes & Cancer
https://read.qxmd.com/read/31258834/inactivated-fabp5-suppresses-malignant-progression-of-prostate-cancer-cells-by-inhibiting-the-activation-of-nuclear-fatty-acid-receptor-ppar%C3%AE
#40
JOURNAL ARTICLE
Waseem Al-Jameel, Xiaojun Gou, Xi Jin, Jiacheng Zhang, Qiang Wei, Jianzhong Ai, Hong Li, Asmaa Al-Bayati, Angela Platt-Higgins, Andrew Pettitt, Philip S Rudland, Youqiang Ke
Previous study has suggested that the FABP5-PPARγ-signalling transduction pathway gradually replaces the androgen receptor activated pathway in promoting malignant progression of castration-resistant prostate cancer (CRPC) cells. To interfere with this newly discovered FABP5-related signalling pathway, we have produced a highly efficient recombinant FABP5 inhibitor, named dmrFABP5. Treatment with dmrFABP5 significantly supressed the proliferation, migration, invasion and colony formation of the highly malignant prostate cancer cells PC3-M in vitro ...
May 2019: Genes & Cancer
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