journal
https://read.qxmd.com/read/38323120/roles-of-usp1-in-ewing-sarcoma
#1
JOURNAL ARTICLE
Panneerselvam Jayabal, Xiuye Ma, Yuzuru Shiio
Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1. We previously reported that Ewing sarcoma harbors two populations of cells, the CD133high population displaying higher growth rate and the CD133low population displaying chemotherapy resistance. We now find that the ubiquitin-specific protease 1 (USP1) is a transcriptional target of the EWS-FLI1 fusion oncoprotein, expressed at high and low levels in the CD133high and the CD133low populations, respectively, and determines chemo-sensitivity...
2024: Genes & Cancer
https://read.qxmd.com/read/38323119/mechanistically-based-blood-proteomic-markers-in-the-tgf-%C3%AE-pathway-stratify-risk-of-hepatocellular-cancer-in-patients-with-cirrhosis
#2
JOURNAL ARTICLE
Xiyan Xiang, Krishanu Bhowmick, Kirti Shetty, Kazufumi Ohshiro, Xiaochun Yang, Linda L Wong, Herbert Yu, Patricia S Latham, Sanjaya K Satapathy, Christina Brennan, Richard J Dima, Nyasha Chambwe, Gulru Sharifova, Fellanza Cacaj, Sahara John, James M Crawford, Hai Huang, Srinivasan Dasarathy, Adrian R Krainer, Aiwu R He, Richard L Amdur, Lopa Mishra
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer worldwide but is often diagnosed at an advanced incurable stage. Yet, despite the urgent need for blood-based biomarkers for early detection, few studies capture ongoing biology to identify risk-stratifying biomarkers. We address this gap using the TGF-β pathway because of its biological role in liver disease and cancer, established through rigorous animal models and human studies. Using machine learning methods with blood levels of 108 proteomic markers in the TGF-β family, we found a pattern that differentiates HCC from non-HCC in a cohort of 216 patients with cirrhosis, which we refer to as TGF-β based Protein Markers for Early Detection of HCC (TPEARLE) comprising 31 markers...
2024: Genes & Cancer
https://read.qxmd.com/read/37705996/severe-herpesvirus-infection-beats-adult-t-cell-leukemia-lymphoma
#3
EDITORIAL
Tatsuro Jo
No abstract text is available yet for this article.
2023: Genes & Cancer
https://read.qxmd.com/read/37705995/increased-expression-of-brd4-isoforms-long-brd4-l-and-short-brd4-s-promotes-chemotherapy-resistance-in-high-grade-serous-ovarian-carcinoma
#4
JOURNAL ARTICLE
Ana Luiza Drumond-Bock, Luyao Wang, Lin Wang, Magdalena Cybula, Maria Rostworowska, Michael Kinter, Magdalena Bieniasz
Chemoresistance in ovarian carcinoma is a puzzling issue that urges understanding of strategies used by cancer cells to survive DNA damage and to escape cell death. Expanding efforts to understand mechanisms driving chemoresistance and to develop alternative therapies targeting chemoresistant tumors are critical. Amplification of BRD4 is frequently associated with chemoresistant ovarian carcinoma, but little is known about the biological effects of the overexpression of BRD4 isoforms in this malignancy. Here, we described the consequences of BRD4-L and BRD4-S overexpression in ovarian carcinoma shedding a light on a complex regulation of BRD4 isoforms...
2023: Genes & Cancer
https://read.qxmd.com/read/37427149/a-novel-t-5-17-q35-q21-associated-with-t-8-21-q22-q22-in-a-patient-with-acute-myeloid-leukemia-case-report-and-review-of-literature
#5
JOURNAL ARTICLE
Kmira Zahra, Wided Cherif, Gereisha Ahmed, Haifa Regaieg, Ben Sayed Nesrine, Monia Zaier, Wided Mootamri, Yosra Ben Youssef, Nejia Brahem, Halima Sennana, Abderrahim Khelif
The t (8; 21) (q22; q22) with the resulting RUNX1- RUNX1T1 rearrangement is one of the most common cytogenetic abnormalities in acute myeloid leukemia (AML). It is associated with favorable prognosis. The t (5; 17) (q35; q21) is an uncommon translocation, fuses the gene for the nucleophosmin (NPM) to the retinoic acid receptor α(RARA) and was described essentially in acute promyelocytic leukemia (APL) variant. We present the case of a 19-year-old male patient who developed an AML with t (8; 21) (q22; q22) associated to t (5; 17) (q35; 21)...
2023: Genes & Cancer
https://read.qxmd.com/read/36923647/vcp-p97-a-pleiotropic-protein-regulator-of-the-dna-damage-response-and-proteostasis-is-a-potential-therapeutic-target-in-kras-mutant-pancreatic-cancer
#6
JOURNAL ARTICLE
Ye S Lee, Jennifer E Klomp, Clint A Stalnecker, Craig M Goodwin, Yanzhe Gao, Gaith N Droby, Cyrus Vaziri, Kirsten L Bryant, Channing J Der, Adrienne D Cox
We and others have recently shown that proteins involved in the DNA damage response (DDR) are critical for KRAS -mutant pancreatic ductal adenocarcinoma (PDAC) cell growth in vitro . However, the CRISPR-Cas9 library that enabled us to identify these key proteins had limited representation of DDR-related genes. To further investigate the DDR in this context, we performed a comprehensive, DDR-focused CRISPR-Cas9 loss-of-function screen. This screen identified valosin-containing protein ( VCP ) as an essential gene in KRAS -mutant PDAC cell lines...
2023: Genes & Cancer
https://read.qxmd.com/read/36741860/ceacams-1-5-and-6-in-disease-and-cancer-interactions-with-pathogens
#7
REVIEW
Jerin Thomas, Addison Klebanov, Sahara John, Larry S Miller, Anil Vegesna, Richard L Amdur, Krishanu Bhowmick, Lopa Mishra
The CEA family comprises 18 genes and 11 pseudogenes located at chromosome 19q13.2 and is divided into two main groups: cell surface anchored CEA-related cell adhesion molecules (CEACAMs) and the secreted pregnancy-specific glycoproteins (PSGs). CEACAMs are highly glycosylated cell surface anchored, intracellular, and intercellular signaling molecules with diverse functions, from cell differentiation and transformation to modulating immune responses associated with infection, inflammation, and cancer. In this review, we explore current knowledge surrounding CEACAM1, CEACAM5, and CEACAM6, highlight their pathological significance in the areas of cancer biology, immunology, and inflammatory disease, and describe the utility of murine models in exploring questions related to these proteins...
2023: Genes & Cancer
https://read.qxmd.com/read/36726965/leveraging-a-powerful-allogeneic-dendritic-cell-line-towards-neoantigen-based-cancer-vaccines
#8
JOURNAL ARTICLE
Dalil Hannani, Estelle Leplus, Karine Laulagnier, Laurence Chaperot, Joël Plumas
In recent years, immunotherapy has finally found its place in the anti-cancer therapeutic arsenal, even becoming standard of care as first line treatment for metastatic forms. The clinical benefit provided by checkpoint blockers such as anti-PD-1/PD-L1 in many cancers revolutionized the field. However, too many patients remain refractory to these treatments due to weak baseline anti-cancer immunity. There is therefore a need to boost the frequency and function of patients' cytotoxic CD8+ cellular effectors by targeting immunogenic and tumor-restricted antigens, such as neoantigens using an efficient vaccination platform...
2023: Genes & Cancer
https://read.qxmd.com/read/36533190/pathogenesis-to-management-of-hepatocellular-carcinoma
#9
REVIEW
Ben L Da, Kelly I Suchman, Lawrence Lau, Atoosa Rabiee, Aiwu Ruth He, Kirti Shetty, Herbert Yu, Linda L Wong, Richard L Amdur, James M Crawford, Sharon S Fox, Gregory M Grimaldi, Priya K Shah, Jonathan Weinstein, David Bernstein, Sanjaya K Satapathy, Nyasha Chambwe, Xiyan Xiang, Lopa Mishra
Hepatocellular carcinoma (HCC) is the most common primary liver cancer whose incidence continues to rise in many parts of the world due to a concomitant rise in many associated risk factors, such as alcohol use and obesity. Although early-stage HCC can be potentially curable through liver resection, liver-directed therapies, or transplantation, patients usually present with intermediate to advanced disease, which continues to be associated with a poor prognosis. This is because HCC is a cancer with significant complexities, including substantial clinical, histopathologic, and genomic heterogeneity...
2022: Genes & Cancer
https://read.qxmd.com/read/36533189/slit2-signaling-stimulates-ewing-sarcoma-growth
#10
JOURNAL ARTICLE
Kruthi Suvarna, Panneerselvam Jayabal, Xiuye Ma, Yuzuru Shiio
Ewing sarcoma is a cancer of bone and soft tissue in children driven by EWS::ETS fusion, most commonly EWS::FLI1. Because current cytotoxic chemotherapies are not improving the survival of those with metastatic or recurrent Ewing sarcoma cases, there is a need for novel and more effective targeted therapies. While EWS::FLI1 is the major driver of Ewing sarcoma, EWS::FLI1 has been difficult to target. A promising alternative approach is to identify and target the molecular vulnerabilities created by EWS::FLI1...
2022: Genes & Cancer
https://read.qxmd.com/read/36471782/systems-biology-network-reveals-the-correlation-between-cox-2-expression-and-ch-7q-copy-number-alterations-in-ch-11q-deleted-pediatric-neuroblastoma-tumors
#11
JOURNAL ARTICLE
Thatyanne Gradowski Farias da Costa do Nascimento, Mateus Eduardo de Oliveira Thomazini, Nilton de França Junior, Lisiane de Castro Poncio, Aline Simoneti Fonseca, Bonald Cavalcante de Figueiredo, Saulo Henrique Weber, Roberto Hirochi Herai, Lucia de Noronha, Luciane R Cavalli, Bruno César Feltes, Selene Elifio-Esposito
Tumor-associated inflammation and chromosomal aberrations can play crucial roles in cancer development and progression. In neuroblastoma (NB), the enzyme cyclooxygenase-2 (COX-2) is associated with copy number alterations on the long arm of chromosome 11 (Ch 11q), defining an aggressive disease subset. This retrospective study included formalin-fixed paraffin-embedded tumor samples collected from nine patients during diagnosis at the pediatric Pequeno Principe Hospital, Curitiba, PR, Brazil, and post-chemotherapy (CT)...
2022: Genes & Cancer
https://read.qxmd.com/read/36471781/ectopic-expression-of-lncrna-mvih-as-a-potential-diagnostic-biomarker-in-cervical-cancer
#12
JOURNAL ARTICLE
Mohammad Ghanbari, Aida Aghazadeh, Elaheh Malekabbaslou, Ali Rajabi, Aref Sobhkhizy, Melika Maydanchi, Ali Saber, Reza Safaralizadeh
AIM: Cervical cancer (CC) is one of the most common cancers in women. Recent advances in screening and vaccination against the papilloma virus (HPV) have increased protection against CC. However, there is no effective diagnostic biomarker and treatment approach during the course of the disease. The current study is thus aimed to evaluate the changes in the expression of lncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) and its diagnostic value as a biomarker in CC patients...
2022: Genes & Cancer
https://read.qxmd.com/read/36051752/reaching-beyond-family-history-as-inclusion-criteria-for-pancreatic-cancer-surveillance-in-high-risk-populations
#13
EDITORIAL
Louise Wang, Susan M Domchek, Michael L Kochman, Bryson W Katona
No abstract text is available yet for this article.
2022: Genes & Cancer
https://read.qxmd.com/read/36051751/cdk4-a-master-regulator-of-the-cell-cycle-and-its-role-in-cancer
#14
REVIEW
Stacey J Baker, Poulikos I Poulikakos, Hanna Y Irie, Samir Parekh, E Premkumar Reddy
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although Cdk 4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics...
2022: Genes & Cancer
https://read.qxmd.com/read/36051750/splice-modulating-oligomers-as-cancer-therapeutics
#15
EDITORIAL
KuanHui E Chen, Ameae M Walker
No abstract text is available yet for this article.
2022: Genes & Cancer
https://read.qxmd.com/read/35677836/using-quantitative-immunohistochemistry-in-patients-at-high-risk-for-hepatocellular-cancer
#16
JOURNAL ARTICLE
Sobia Zaidi, Richard Amdur, Xiyan Xiang, Herbert Yu, Linda L Wong, Shuyun Rao, Aiwu R He, Karan Amin, Daewa Zaheer, Raj K Narayan, Sanjaya K Satapathy, Patricia S Latham, Kirti Shetty, Chandan Guha, Nancy R Gough, Lopa Mishra
Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a major cause of cancer death worldwide. Early detection is key to effective treatment. Yet, early diagnosis is challenging, especially in patients with cirrhosis, who are at high risk of developing HCC. Dysfunction or loss of function of the transforming growth factor β (TGF-β) pathway is associated with HCC. Here, using quantitative immunohistochemistry analysis of samples from a multi-institutional repository, we evaluated if differences in TGF-β receptor abundance were present in tissue from patients with only cirrhosis compared with those with HCC in the context of cirrhosis...
2022: Genes & Cancer
https://read.qxmd.com/read/35186192/expression-of-hotair-and-meg3-are-negatively-associated-with-h-pylori-positive-status-in-gastric-cancer-patients
#17
JOURNAL ARTICLE
Farnaz Amini, Mohammad Khalaj-Kondori, Amin Moqadami, Ali Rajabi
BACKGROUND: Chronic infection with Helicobacter pylori is one of the main causes of gastric cancer (GC). Besides, lncRNAs play crucial roles in cancer pathobiology including GC. Here we aimed to investigate the expression of MEG3 and HOTAIR in gastric cancer tissues and evaluate their association with the H. pylori status. MATERIALS AND METHODS: One hundred samples were obtained. Total RNA was extracted, cDNA was synthesized and expression of MEG3 and HOTAIR was assessed using qRT-PCR...
2022: Genes & Cancer
https://read.qxmd.com/read/34966479/ezh2-suppresses-endogenous-retroviruses-and-an-interferon-response-in-cancers
#18
JOURNAL ARTICLE
Panneerselvam Jayabal, Xiuye Ma, Yuzuru Shiio
Ewing sarcoma is an aggressive cancer of bone and soft tissue in children. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, most commonly FLI1. We recently reported that Ewing sarcoma depends on the autocrine signaling mediated by a cytokine, NELL2. NELL2 signaling stimulates the transcriptional output of EWS-FLI1 through the BAF chromatin remodeling complexes. While studying the impact of NELL2 silencing on Ewing sarcoma, we found that suppression of NELL2 signaling induces the expression of endogenous retroviruses (ERVs) and LINE-1 retrotransposons, an interferon response, and growth arrest...
2021: Genes & Cancer
https://read.qxmd.com/read/34659647/genomic-profiling-of-dvl-1-and-its-nuclear-role-as-a-transcriptional-regulator-in-triple-negative-breast-cancer
#19
JOURNAL ARTICLE
Monica Sharma, Isabel Castro-Piedras, Austin Dwight Rodgers, Kevin Pruitt
Dishevelled-1 (DVL-1) mediates Wnt signals critical for development and cellular homeostasis. DVL-1 is also linked with tumorigenesis, however its association with specific breast cancer (BC) subtypes and how it contributes to tumorigenicity remains poorly studied. Herein, using bioinformatics and genomics analyses, we investigate the role of DVL-1 in different molecular subtypes of BC. Our results demonstrate that DVL-1 is highly expressed in triple-negative BC compared to non-cancer tissues and associated with various clinical factors that may contribute to poor prognosis and survival rate...
2021: Genes & Cancer
https://read.qxmd.com/read/34163562/pairwise-correlation-of-genes-involved-in-glucose-metabolism-a-potential-diagnostic-marker-of-cancer
#20
JOURNAL ARTICLE
Meena Kishore Sakharkar, Karthic Rajamanickam, Shaoping Ji, Sarinder Kaur Dhillon, Jian Yang
Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes ADH1B and PDHA2 were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer...
2021: Genes & Cancer
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