Ben L Da, Kelly I Suchman, Lawrence Lau, Atoosa Rabiee, Aiwu Ruth He, Kirti Shetty, Herbert Yu, Linda L Wong, Richard L Amdur, James M Crawford, Sharon S Fox, Gregory M Grimaldi, Priya K Shah, Jonathan Weinstein, David Bernstein, Sanjaya K Satapathy, Nyasha Chambwe, Xiyan Xiang, Lopa Mishra
Hepatocellular carcinoma (HCC) is the most common primary liver cancer whose incidence continues to rise in many parts of the world due to a concomitant rise in many associated risk factors, such as alcohol use and obesity. Although early-stage HCC can be potentially curable through liver resection, liver-directed therapies, or transplantation, patients usually present with intermediate to advanced disease, which continues to be associated with a poor prognosis. This is because HCC is a cancer with significant complexities, including substantial clinical, histopathologic, and genomic heterogeneity...
2022: Genes & Cancer