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Cardiology Research and Practice

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https://www.readbyqxmd.com/read/28512592/the-relationship-between-body-mass-index-and-the-severity-of-coronary-artery-disease-in-patients-referred-for-coronary-angiography
#1
Anne B Gregory, Kendra K Lester, Deborah M Gregory, Laurie K Twells, William K Midodzi, Neil J Pearce
Background and Aim. Obesity is associated with an increased risk of cardiovascular disease and may be associated with more severe coronary artery disease (CAD); however, the relationship between body mass index [BMI (kg/m(2))] and CAD severity is uncertain and debatable. The aim of this study was to examine the relationship between BMI and angiographic severity of CAD. Methods. Duke Jeopardy Score (DJS), a prognostic tool predictive of 1-year mortality in CAD, was assigned to angiographic data of patients ≥18 years of age (N = 8,079)...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/28465858/the-prevalence-and-awareness-of-cardiovascular-diseases-risk-factors-among-the-lebanese-population-a-prospective-study-comparing-urban-to-rural-populations
#2
Iqbal Fahs, Zainab Khalife, Diana Malaeb, Mohammad Iskandarani, Pascale Salameh
Introduction. CVDs are largely driven by modifiable risk factors. This study sought to determine the awareness and prevalence of the modifiable CVDs risk factors among the Lebanese population. Methods. In a cross-sectional survey, 1000 participants aged ≥ 45 years were randomly selected from pharmacies and interviewed. The data was analyzed with SPSS version 21.0 software. Results. Differences between urban and rural areas include alcohol consumption (2.8% versus 1.7%; p = 0.0001), cardioprotective vegetable servings (6...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/28421156/the-personalization-of-clopidogrel-antiplatelet-therapy-the-role-of-integrative-pharmacogenetics-and-pharmacometabolomics
#3
REVIEW
Arwa M Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali Sk Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim
Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention. However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular events. Although many genetic and nongenetic factors are known, great portion of clopidogrel variable platelets reactivity remain unexplained which challenges the personalization of clopidogrel therapy. Current methods for clopidogrel personalization include CYP2C19 genotyping, pharmacokinetics, and platelets function testing...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/28348916/aerobic-training-intensity-for-improved-endothelial-function-in-heart-failure-patients-a-systematic-review-and-meta-analysis
#4
M J Pearson, N A Smart
Objective. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and aerobic exercise improves FMD in heart failure patients. The aim of this meta-analysis is to quantify the effect of aerobic training intensity on FMD in patients with heart failure. Background. A large number of studies now exist that examine endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of the aerobic training intensity on endothelial function...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/28246571/avoiding-the-learning-curve-for-transcatheter-aortic-valve-replacement
#5
Sergey Gurevich, Ranjit John, Rosemary F Kelly, Ganesh Raveendran, Gregory Helmer, Demetris Yannopoulos, Timinder Biring, Brett Oestreich, Santiago Garcia
Objectives. To evaluate whether collaboration between existing and new transcatheter aortic valve replacement (TAVR) programs could help reduce the number of cases needed to achieve optimal efficiency. Background. There is a well-documented learning curve for achieving procedural efficiency and safety in TAVR procedures. Methods. A multidisciplinary collaboration was established between the Minneapolis VA Medical Center (new program) and the University of Minnesota (established program since 2012, n = 219) 1 year prior to launching the new program...
2017: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27974990/pediatric-heart-failure-lagging-and-sagging-of-care-in-low-income-settings-a-hospital-based-review-of-cases-in-ethiopia
#6
Solmon Gebremariam, Tamirat Moges
Introduction. Causes of acute heart failure in children range from simple myocarditis complicating chest infection to complex structural heart diseases. Objective. To describe patterns, predictors of mortality, and management outcomes of acute heart failure in children. Methods. In retrospective review, between February 2012 and October 2015 at a tertiary center, 106 admitted cases were selected consecutively from discharge records. Data were extracted from patients chart and analyzed using SPSS software package...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27965912/impact-of-lifestyle-intervention-on-hdl-induced-enos-activation-and-cholesterol-efflux-capacity-in-obese-adolescent
#7
Jenny Wesnigk, Luc Bruyndonckx, Vicky Y Hoymans, Ann De Guchtenaere, Tina Fischer, Gerhard Schuler, Christiaan J Vrints, Volker Adams
Background. Endothelial dysfunction occurs in obese children and adolescent and is regarded as a key step in the development of atherosclerosis. Important components for the development of endothelial dysfunction are reduced activity of endothelial nitric oxide synthase (eNOS) and an increase in cholesterol deposition in the vessel wall, due to reduced reverse cholesterol transport (RCT) activity. High density lipoprotein (HDL) exhibits antiatherosclerotic properties including modulation of eNOS activity and cholesterol efflux capacity...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27885351/coronary-angiography-safety-between-transradial-and-transfemoral-access
#8
Santosh Kumar Sinha, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Mohammad Asif, Ramesh Thakur, Chandra Mohan Varma
Background and Aim. The aim of study was to evaluate safety, feasibility, and procedural variables of transradial approach compared with transfemoral approach in a standard population of patients undergoing coronary catheterization as one of the major criticisms of the transradial approach is that it takes longer overall procedure and fluoroscopy time, thereby causing more radiation exposure. Method. Between January 2015 and December 2015, a total of 1,997 patients in LPS Institute of Cardiology, GSVM Medical College, Kanpur, UP, India, undergoing coronary catheterization were randomly assigned to the transradial or transfemoral approach...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27882261/prevalence-of-hepatitis-c-virus-seropositivity-and-its-impact-on-coronary-artery-disease-among-egyptian-patients-referred-for-coronary-angiography
#9
Ragab Abd El Salam, Baher Nabil, Marawan Saber, Hany A AbdelWahab, Tamer Saber
Background. We tested the prevalence and impact of HCV seropositivity among Egyptian patients referred for coronary angiography. Subjects and Methods. This cross-sectional study was conducted in Zagazig University hospitals including 509 patients scheduled for elective coronary angiography between June 2013 and June 2014. By taking full history on admission, laboratory workup including HCV Ab, echocardiography study, and coronary angiography, we calculated the mean number of coronary artery lesions and the mean number of affected coronary artery vessels for all patients...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27872790/kansas-city-cardiomyopathy-questionnaire-utility-in-prediction-of-30-day-readmission-rate-in-patients-with-chronic-heart-failure
#10
Shengchuan Dai, Manoucher Manoucheri, Junhong Gui, Xiang Zhu, Divyanshu Malhotra, Shenjing Li, Jason D'souza, Fnu Virkram, Aditya Chada, Haibing Jiang
Background. Heart failure (HF) is one of the most common diagnoses associated with hospital readmission. We designed this prospective study to evaluate whether Kansas City Cardiomyopathy Questionnaire (KCCQ) score is associated with 30-day readmission in patients hospitalized with decompensated HF. Methods and Results. We enrolled 240 patients who met the study criteria. Forty-eight (20%) patients were readmitted for decompensated HF within thirty days of hospital discharge, and 192 (80%) patients were not readmitted...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27668118/impact-of-body-mass-index-on-short-term-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-in-newfoundland-and-labrador-canada
#11
Anne B Gregory, Kendra K Lester, Deborah M Gregory, Laurie K Twells, William K Midodzi, Neil J Pearce
Background and Aim. Obesity (BMI ≥ 30 kg/m(2)) is associated with advanced cardiovascular disease requiring procedures such as percutaneous coronary intervention (PCI). Studies report better outcomes in obese patients having these procedures but results are conflicting or inconsistent. Newfoundland and Labrador (NL) has the highest rate of obesity in Canada. The aim of the study was to examine the relationship between BMI and vascular and nonvascular complications in patients undergoing PCI in NL. Methods...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27597926/association-between-stable-coronary-artery-disease-and-in-vivo-thrombin-generation
#12
Benjamin Valente-Acosta, Manuel Alfonso Baños-González, Marco Antonio Peña-Duque, Marco Antonio Martínez-Ríos, Leslie Quintanar-Trejo, Gad Aptilon-Duque, Mirthala Flores-García, David Cruz-Robles, Guillermo Cardoso-Saldaña, Aurora de la Peña-Díaz
Background. Thrombin has been implicated as a key molecule in atherosclerotic progression. Clinical evidence shows that thrombin generation is enhanced in atherosclerosis, but its role as a risk factor for coronary atherosclerotic burden has not been proven in coronary artery disease (CAD) stable patients. Objectives. To evaluate the association between TAT levels and homocysteine levels and the presence of coronary artery disease diagnosed by coronary angiography in patients with stable CAD. Methods and Results...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27563480/impact-of-rosuvastatin-treatment-on-hdl-induced-pkc-%C3%AE-ii-and-enos-phosphorylation-in-endothelial-cells-and-its-relation-to-flow-mediated-dilatation-in-patients-with-chronic-heart-failure
#13
Ephraim B Winzer, Pauline Gaida, Robert Höllriegel, Tina Fischer, Axel Linke, Gerhard Schuler, Volker Adams, Sandra Erbs
Background. Endothelial function is impaired in chronic heart failure (CHF). Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function. Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser(1177), dephosphorylation at Thr(495), and diminished phosphorylation of PKC-βII at Ser(660). The aim of this study was to elucidate the impact of rosuvastatin on HDL mediated eNOS and PKC-βII phosphorylation and its relation to endothelial function. Methods...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27555978/cardiac-arrhythmias-update-on-mechanisms-and-clinical-managements
#14
Yi-Gang Li, David G Benditt, Thomas Klingenheben, Kai Hu, Dali Feng
No abstract text is available yet for this article.
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27429833/the-concordance-between-myocardial-perfusion-imaging-and-coronary-angiography-in-detecting-coronary-artery-disease-a-retrospective-study-in-a-tertiary-cardiac-center-at-king-abdullah-medical-city
#15
Fatma Aboul-Enein, Majed O Aljuaid, Hail T Alharthi, Abdulkarim M Almudhhi, Mohammad A Alzahrani
Background. Coronary artery disease (CAD) is considered as the leading cause of the cardiovascular fatalities worldwide. CAD is diagnosed by many modalities of imaging such as myocardial perfusion imaging (MPI) and coronary angiography (CAG). Methods. A retrospective cross-sectional study was conducted that included all patients referred to the KAMC (King Abdullah Medical City) nuclear cardiology lab from its opening until the end of May 2014 (a period of 17 months). A total of 228 patient reports with a history of conducting either CAG or MPI or both were used in this study and statistically analyzed...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27313944/frequency-of-specific-cardiovascular-disease-risk-factors-among-cameroonian-patients-on-dialysis-the-cases-of-anaemia-inflammation-phosphate-and-calcium
#16
Olivier Pancha Mbouemboue, Olivier Djile Danbe, Marcel Tangyi Tamanji, Jacques Olivier Ngoufack
Specific cardiovascular risk factors are known to contribute to increasing cardiovascular mortality in patients with chronic renal disease. However, little is known about their distribution in our population. This study aimed at determining the prevalence of anaemia, inflammation, and phosphocalcium disorders in Cameroonian patients on dialysis. Thirty-five participants with stage V chronic kidney disease (defined by glomerular filtration rate, GFR < 15 mL/1.73 m(3)) of age at least 20 years on haemodialysis were randomly recruited...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27313943/myocardial-viability-from-proof-of-concept-to-clinical-practice
#17
REVIEW
Aditya Bhat, Gary C H Gan, Timothy C Tan, Chijen Hsu, Alan Robert Denniss
Ischaemic left ventricular (LV) dysfunction can arise from myocardial stunning, hibernation, or necrosis. Imaging modalities have become front-line methods in the assessment of viable myocardial tissue, with the aim to stratify patients into optimal treatment pathways. Initial studies, although favorable, lacked sufficient power and sample size to provide conclusive outcomes of viability assessment. Recent trials, including the STICH and HEART studies, have failed to confer prognostic benefits of revascularisation therapy over standard medical management in ischaemic cardiomyopathy...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27213077/incidence-and-factors-predicting-skin-burns-at-the-site-of-indifferent-electrode-during-radiofrequency-catheter-ablation-of-cardiac-arrhythmias
#18
Hussain Ibrahim, Bohuslav Finta, Jubran Rind
Radiofrequency catheter ablation (RFA) has become a mainstay for treatment of cardiac arrhythmias. Skin burns at the site of an indifferent electrode patch have been a rare, serious, and likely an underreported complication of RFA. The purpose of this study was to determine the incidence of skin burns in cardiac RFA procedures performed at one institution. Also, we wanted to determine the factors predicting skin burns after cardiac RFA procedures at the indifferent electrode skin pad site. Methods. A retrospective case control study was performed to compare the characteristics in patients who developed skin burns in a 2-year period...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27213076/epicardial-fat-physiological-pathological-and-therapeutic-implications
#19
REVIEW
Juan Salazar, Eliana Luzardo, José Carlos Mejías, Joselyn Rojas, Antonio Ferreira, José Ramón Rivas-Ríos, Valmore Bermúdez
Epicardial fat is closely related to blood supply vessels, both anatomically and functionally, which is why any change in this adipose tissue's behavior is considered a potential risk factor for cardiovascular disease development. When proinflammatory adipokines are released from the epicardial fat, this can lead to a decrease in insulin sensitivity, low adiponectin production, and an increased proliferation of vascular smooth muscle cells. These adipokines move from one compartment to another by either transcellular passing or diffusion, thus having the ability to regulate cardiac muscle activity, a phenomenon called vasocrine regulation...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27200206/the-modification-effect-of-influenza-vaccine-on-prognostic-indicators-for-cardiovascular-events-after-acute-coronary-syndrome-observations-from-an-influenza-vaccination-trial
#20
Apirak Sribhutorn, Arintaya Phrommintikul, Wanwarang Wongcharoen, Usa Chaikledkaew, Suntara Eakanunkul, Apichard Sukonthasarn
Introduction. The prognosis of acute coronary syndrome (ACS) patients has been improved with several treatments such as antithrombotics, beta-blockers, and angiotensin-converting enzyme inhibitors (ACEI) as well as coronary revascularization. Influenza vaccination has been shown to reduce adverse outcomes in ACS, but no information exists regarding the interaction of other treatments. Methods. This study included 439 ACS patients from Phrommintikul et al. A single dose of inactivated influenza vaccine was given by intramuscular injection in the vaccination group...
2016: Cardiology Research and Practice
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