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International Journal of Endocrinology

Sándor Somodi, Ildikó Seres, Hajnalka Lőrincz, Mariann Harangi, Péter Fülöp, György Paragh
Background: The elevated level of plasminogen activator inhibitor-1 (PAI-1) in obese subjects with metabolic syndrome and in patients with type 2 diabetes is well established. The association of plasma PAI-1 and lipid metabolism is still unclear. The aim of the present study was to determine the relationship between plasma PAI-1 levels and the distribution of lipoprotein subfractions in obese and lean nondiabetic individuals. Subjects and Methods: We enrolled fifty nondiabetic obese patients and thirty-two healthy volunteers...
2018: International Journal of Endocrinology
Krisztian Sepp, Anna M Laszlo, Zsolt Molnar, Andrea Serester, Tunde Alapi, Marta Galfi, Zsuzsanna Valkusz, Marianna Radacs
Uron herbicides polluting the environment represent a serious concern for environmental health and may be regarded as endocrine-disrupting compounds (EDCs), which influence the regulation of human homeostasis. We aimed to investigate the effect of EDC urons (phenuron: PU, monuron: MU, and diuron: DU) and chlorobenzenes on the basal release of the adrenocorticotropic hormone (ACTH), which is a part of the adenohypophysis-adrenocortical axis. Hormone secretion in the presence of EDC was studied in two cell types: normal adenohypophysis cells (AdH) and cells of prolactinomas (PRLOMA)...
2018: International Journal of Endocrinology
I Migdalis, L Czupryniak, N Lalic, R D Leslie, N Papanas, P Valensi
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
Deanna J M Isaman, Amy E Rothberg
Background: Despite the attention given to the prevalence of obesity, surprisingly little is known about the incidence or reduction of obesity. We report the 1-year incidence and remission of obesity in a representative sample of the US population. Methods: Individuals from the Medical Expenditure Panel Survey (MEPS) panel 17 were classified into standard obesity categories at enrollment and one year later. Incidence rates were calculated by age. Results: Although the overall prevalence of obesity remained nearly constant, remission rates from obesity (stratified by age) ranged from 11 to 27% while incidence rates ranged from 6 to 16%...
2018: International Journal of Endocrinology
Rongrong Xie, Linqi Chen, Haiying Wu, Ting Chen, Fengyun Wang, Xiuli Chen, Hui Sun, Xiaozhong Li
Background: Gonadal injury following chemotherapy is of increasing importance with the continuous improvement of survival rates. The protection of gonadotropin hormone antagonist (GnRHant) in long-term adult survivors of adolescent cancers and some autoimmune diseases has not yet been evaluated. Methods: The present study was aimed at longitudinally exploring whether the GnRHant could alleviate testicular damage induced by cyclophosphamide (CPA) in a rat model. Pubertal male rats were assigned to receive CPA with and without GnRHant...
2018: International Journal of Endocrinology
Patrycja Kurowska, Alix Barbe, Marta Różycka, Justyna Chmielińska, Joelle Dupont, Agnieszka Rak
Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue...
2018: International Journal of Endocrinology
Xinxin Chen, Yulin Zhou, Mengxi Zhou, Qinglei Yin, Shu Wang
Background: The results of previous studies on the usefulness of free triiodothyronine (FT3) to free thyroxine (FT4) are controversial. We investigated the usefulness of FT3, FT4, and FT3/FT4 ratio in differentiating Graves' disease (GD) from destructive thyroiditis. Methods: A total of 126 patients with untreated GD, 36 with painless thyroiditis, 18 with painful subacute thyroiditis, and 63 healthy controls, were recruited. The levels of FT3 and FT4 and the FT3/FT4 ratios for the different etiologies of thyrotoxicosis were evaluated separately by receiver operating characteristic (ROC) curve analysis...
2018: International Journal of Endocrinology
Alexandre Connolly, Samuel Leblanc, Jean-Patrice Baillargeon
Polycystic ovary syndrome (PCOS) is a common and significant condition associated with hyperandrogenism, infertility, low quality of life, and metabolic comorbidities. One possible explanation of PCOS development is cellular dysfunction induced by nonesterified fatty acids (NEFAs), that is, lipotoxicity, which could explain both the hyperandrogenemia and insulin resistance that characterize women with PCOS. The literature suggests that androgen biosynthesis may be induced by overexposure of androgen-secreting tissues to NEFA and/or defective NEFA metabolism, leading to lipotoxic effects...
2018: International Journal of Endocrinology
Yaelle Elfassy, Jean-Philippe Bastard, Chloe McAvoy, Soraya Fellahi, Joëlle Dupont, Rachel Levy
Adipokines are secreted by adipose tissue and could be the link between obesity and infertility. Different studies investigated the involvement of adipokines in reproductive functions but only a few have looked into the male part. This review assesses adipokine functions on male reproductive parameters. Adiponectin seems to have a positive effect on sperm parameters, whereas other adipokines such as resistin or chemerin would have a rather deleterious effect on spermatogenesis. Semen parameters seem to be impacted when resistin and chemerin are increased: indeed, there is a decrease of sperm motility...
2018: International Journal of Endocrinology
Agata Bronisz, Mateusz Ozorowski, Magdalena Hagner-Derengowska
Glucose is the major source of energy for the human brain which in turn uses ketone bodies as a supplement for energy deficit in glucose cell deficiency conditions. Pregnancy complicated by gestational diabetes is a condition associated with significantly increased risk of ketonemia development. The data available proves a changing influence of ketones on the central nervous system during fetal life and in adults as well. Ketone bodies freely pass through the placenta. They can affect fetal growth and organ damage development, especially the central nervous system...
2018: International Journal of Endocrinology
Ben Ma, Weibo Xu, Wenjun Wei, Duo Wen, Zhongwu Lu, Shuwen Yang, Tongzhen Chen, Yulong Wang, Yu Wang, Qinghai Ji
Background: Recently, several studies have reported that dedifferentiation occurs in fatal well-differentiated thyroid cancer (WDTC) cases. This study aimed at investigating the clinicopathological characteristics of WDTC undergoing dedifferentiation. Methods: A total of 63 WDTC patients harboring dedifferentiated phenotype were enrolled in the study. The Kaplan-Meier method and Cox regression analysis were used to perform survival analyses. Harrell index of concordance (C-index) and Akaike information criterion (AIC) were calculated to compare the predictive value for prognosis among several prognostic classification systems...
2018: International Journal of Endocrinology
Krzysztof Kaliszewski, Beata Wojtczak, Jędrzej Grzegrzółka, Jacob Bronowicki, Sawsan Saeid, Bartłomiej Knychalski, Zdzisław Forkasiewicz
Objectives: A discussion with regard to the most optimal surgical procedure in nontoxic multinodular goitre (NTMNG). We assessed and compared three main types of operations in 2032 patients with NTMNG. Methods: This is a retrospective study of 2032 patients operated on in one center due to NTMNG. The observation period was 48 to 120 months (mean and SD: 87 ± 20). Results: The early complications included uni- and bilateral recurrent laryngeal nerve paralysis (URLNP, BRLNP), overt tetany (OT), and postoperative bleeding (POB)...
2018: International Journal of Endocrinology
P Popova, L Vasilyeva, A Tkachuck, M Puzanov, A Golovkin, Y Bolotko, E Pustozerov, E Vasilyeva, O Li, I Zazerskaya, R Dmitrieva, A Kostareva, E Grineva
Our aim was to study the expression of adipokine-encoding genes (leptin, adiponectin, and angiopoietin-like protein 4 (ANGPTL4)) in human umbilical vein endothelial cells (HUVECs) and adipokine concentration in cord blood from women with gestational diabetes mellitus (GDM) depending on glycaemic targets. GDM patients were randomised to 2 groups per target glycaemic levels: GDM1 (tight glycaemic targets, fasting blood glucose < 5.1 mmol/L and <7.0 mmol/L postprandial, N = 20) and GDM2 (less tight glycaemic targets, <5...
2018: International Journal of Endocrinology
Min Joo Kim, Sun Wook Cho, Sumin Choi, Dal Lae Ju, Do Joon Park, Young Joo Park
Objectives: Because thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves' disease. Methods: A prospective cohort study was performed with six women newly diagnosed with Graves' disease. During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively...
2018: International Journal of Endocrinology
Shiferaw Birhanu Aynalem, Ayalew Jejaw Zeleke
Introduction: Diabetes mellitus (DM), which is related to cardiovascular disease, is one of the main global health problems. In Ethiopia, information about this disease is known to be scarce. Objective: To assess the prevalence of diabetes mellitus and its risk factors among individuals aged 15 years and above. Methods: A community-based cross sectional study was carried out from January 01 to March 30, 2016 in Mizan-Aman town, southwest Ethiopia...
2018: International Journal of Endocrinology
Xu-Hang Zhu, Bin Yu, Yu-Qing Huang, Jing-Nan Zhou, Ming-Hua Ge
[This corrects the article DOI: 10.1155/2017/5702716.].
2018: International Journal of Endocrinology
F Belva, M Bonduelle, S Provyn, R C Painter, H Tournaye, M Roelants, J De Schepper
Background: Intracytoplasmic sperm injection (ICSI) conception presents the early embryo with a radically different environment, which may lead to permanent alterations to key cardiometabolic processes. Blood pressure, indicators of insulin resistance, and lipid profiles have previously been studied in offspring born after in vitro fertilisation (IVF) and ICSI, with conflicting findings. Also, results in young adults born after ICSI are lacking. Aim: We investigated if young adult men and women conceived by ICSI more frequently have metabolic syndrome and its individual features in comparison to spontaneously conceived controls...
2018: International Journal of Endocrinology
Kamil Dobrzyn, Nina Smolinska, Marta Kiezun, Karol Szeszko, Edyta Rytelewska, Katarzyna Kisielewska, Marlena Gudelska, Tadeusz Kaminski
Adiponectin is the hormone that belongs to the group of adipokines, chemical agents mainly derived from the white adipose tissue. The hormone plays pleiotropic roles in the organism, but the most important function of adiponectin is the control of energy metabolism. The presence of adiponectin and its receptors in the structures responsible for the regulation of female reproductive functions, such as hypothalamic-pituitary-gonadal (HPG) axis, indicates that adiponectin may be involved in the female fertility regulation...
2018: International Journal of Endocrinology
Adriana Graciela Díaz, Andrea Paes de Lima, Paula Garibaldi, Maria de Los Milagros Rubio, Florencia García, Marta Kral, Oscar D Bruno
Insulinomas are pancreatic neuroendocrine tumors (pNET), usually benign. Akt/p27kip1 is an intracellular pathway overexpressed in many pNET. There are no data regarding its expression in human insulinomas. We aimed to investigate the expression of Akt and p27kip1 in 24 human insulinomas and to compare them to their expression in normal surrounding islets. Staining was performed on embedded paraffin tissue using polyclonal antibodies against total Akt, p-Akt, p27kip1 , and pp27kip1 . p-Akt was the predominant form in insulinomas; they presented lower Akt and p-Akt expression than normal islets in 83...
2018: International Journal of Endocrinology
Sonja G Karst, Jan Lammer, Salma H Radwan, Hanna Kwak, Paolo S Silva, Stephen A Burns, Lloyd Paul Aiello, Jennifer K Sun
Purpose: To characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques. Methods: Cross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images...
2018: International Journal of Endocrinology
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