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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/28074095/multidisciplinary-management-of-pituitary-apoplexy
#1
REVIEW
Adriana Albani, Francesco Ferraù, Filippo Flavio Angileri, Felice Esposito, Francesca Granata, Felicia Ferreri, Salvatore Cannavò
Pituitary apoplexy is a rare clinical syndrome due to ischemic or haemorrhagic necrosis of the pituitary gland which complicates 2-12% of pituitary tumours, especially nonfunctioning adenomas. In many cases, it results in severe neurological, ophthalmological, and endocrinological consequences and may require prompt surgical decompression. Pituitary apoplexy represents a rare medical emergency that necessitates a multidisciplinary approach. Modalities of treatment and times of intervention are still largely debated...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28074094/to-identify-predictors-of-central-lymph-node-metastasis-in-patients-with-clinically-node-negative-conventional-papillary-thyroid-carcinoma
#2
Jiru Yuan, Gang Zhao, Jialin Du, Xiaoyi Chen, Xiaodong Lin, Zhengbo Chen, Zeyu Wu
Objective. The aim of this study was to identify the risk factors associated with central lymph node metastasis (CLNM) in patients with clinically node-negative conventional papillary thyroid carcinoma (cN0 CPTC). Methods. A total of 190 cN0 CPTC patients who underwent thyroidectomy with prophylactic central neck dissection (pCND) in the Department of General Surgery at Guangdong General Hospital between March 2014 and December 2015 were assessed retrospectively. The relations of CLNM with clinicopathologic characteristics of cN0 CPTC were analyzed by univariate and multivariate logistic regression...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28050167/maternal-diet-supplementation-with-n-6-n-3-essential-fatty-acids-in-a-1-2%C3%A2-%C3%A2-1-0-ratio-attenuates-metabolic-dysfunction-in-msg-induced-obese-mice
#3
Josiane Morais Martin, Rosiane Aparecida Miranda, Luiz Felipe Barella, Kesia Palma-Rigo, Vander Silva Alves, Gabriel Sergio Fabricio, Audrei Pavanello, Claudinéia Conationi da Silva Franco, Tatiane Aparecida Ribeiro, Jesuí Vergílio Visentainer, Elton Guntendeorfer Banafé, Clayton Antunes Martin, Paulo Cezar de Freitas Mathias, Júlio Cezar de Oliveira
Essential polyunsaturated fatty acids (PUFAs) prevent cardiometabolic diseases. We aimed to study whether a diet supplemented with a mixture of n-6/n-3 PUFAs, during perinatal life, attenuates outcomes of long-term metabolic dysfunction in prediabetic and obese mice. Seventy-day-old virgin female mice were mated. From the conception day, dams were fed a diet supplemented with sunflower oil and flaxseed powder (containing an n-6/n-3 PUFAs ratio of 1.2 : 1.0) throughout pregnancy and lactation, while control dams received a commercial diet...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28044078/erratum-to-inositols-in-the-treatment-of-insulin-mediated-diseases
#4
Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà, Francesco Orio
[This corrects the article DOI: 10.1155/2016/3058393.].
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28044077/fracture-risk-in-type-2-diabetes-current-perspectives-and-gender-differences
#5
REVIEW
Giuseppina T Russo, Annalisa Giandalia, Elisabetta L Romeo, Morabito Nunziata, Marco Muscianisi, Maria Concetta Ruffo, Antonino Catalano, Domenico Cucinotta
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fractures, resulting in disabilities and increased mortality. The pathophysiological mechanisms linking diabetes to osteoporosis have not been fully explained, but alterations in bone structure and quality are well described in diabetic subjects, likely due to a combination of different factors. Insulin deficiency and dysfunction, obesity and hyperinsulinemia, altered level of oestrogen, leptin, and adiponectin as well as diabetes-related complications, especially peripheral neuropathy, orthostatic hypotension, or reduced vision due to retinopathy may all be associated with an impairment in bone metabolism and with the increased risk of fractures...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28042294/gender-differences-in-risks-of-coronary-heart-disease-and-stroke-in-patients-with-type-2-diabetes-mellitus-and-their-association-with-metabolic-syndrome-in-china
#6
Mei-Fang Yao, Jie He, Xue Sun, Xiao-Li Ji, Yue Ding, Yi-Ming Zhao, Han-Yu Lou, Xiao-Xiao Song, Li-Zhen Shan, Ying-Xiu Kang, Song-Zhao Zhang, Peng-Fei Shan
Coronary heart disease (CHD) and stroke are common complications of type 2 diabetes mellitus (T2DM). We aimed to explore the differences in the risks of CHD and stroke between Chinese women and men with T2DM and their association with metabolic syndrome (MS). This study included 1514 patients with T2DM. The Asian Guidelines of ATPIII (2005) were used for MS diagnosis, and the UKPDS risk engine was used to evaluate the 10-year CHD and stroke risks. Women had lower CHD risk (15.3% versus 26.3%), fatal CHD risk (11...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28018430/gc-gene-polymorphisms-and-vitamin-d-binding-protein-levels-are-related-to-the-risk-of-generalized-aggressive-periodontitis
#7
Wenli Song, Xian'e Wang, Yu Tian, Xin Zhang, Ruifang Lu, Huanxin Meng
Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28018429/408-cases-of-genital-ambiguity-followed-by-single-multidisciplinary-team-during-23-years-etiologic-diagnosis-and-sex-of-rearing
#8
Georgette Beatriz De Paula, Beatriz Amstalden Barros, Stela Carpini, Bruna Jordan Tincani, Tais Nitsch Mazzola, Mara Sanches Guaragna, Cristiane Santos da Cruz Piveta, Laurione Candido de Oliveira, Juliana Gabriel Ribeiro Andrade, Guilherme Guaragna-Filho, Pedro Perez Barbieri, Nathalia Montibeler Ferreira, Marcio Lopes Miranda, Ezequiel Moreira Gonçalves, Andre Moreno Morcillo, Nilma Lucia Viguetti-Campos, Sofia Helena Valente Lemos-Marini, Roberto Benedito de Paiva Silva, Antonia Paula Marques-de-Faria, Maricilda Palandi De Mello, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior
Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center. Results. There were 408 cases; 250 (61.3%) were 46,XY and 124 (30.4%) 46,XX and 34 (8.3%) had sex chromosomes abnormalities. 189 (46.3%) had 46,XY testicular DSD, 105 (25.7%) 46,XX ovarian DSD, 95 (23.3%) disorders of gonadal development (DGD), and 19 (4.7%) complex malformations...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28003823/larger-thyroid-volume-and-adequate-iodine-nutrition-in-chinese-schoolchildren-local-normative-reference-values-compared-with-who-ign
#9
Zhe Mo, Xiaoming Lou, Guangming Mao, Zhifang Wang, Wenming Zhu, Zhijian Chen, Xiaofeng Wang
Objective. Thyroid volume measured by ultrasound to define goiter needs reliable local thyroid volume reference from iodine-sufficient populations. The aim of this study is to explore the reference interval for normal thyroid volume in schoolchildren aged 8-10 years from Zhejiang Province, China. Methods. A probability-proportionate-to-size sampling method was applied to select a representative sample of 1213 children aged 8-10 years in Zhejiang Province to detect the thyroid volume, salt iodine, and urine iodine...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27999593/long-term-clinical-outcomes-of-invasive-giant-prolactinomas-after-a-mean-ten-year-followup
#10
Ze Rui Wu, Yong Zhang, Lin Cai, Shao Jian Lin, Zhi Peng Su, Yong Xu Wei, Han Bing Shang, Wen Lei Yang, Wei Guo Zhao, Zhe Bao Wu
Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs). Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery prior to BRC treatment. Results. After a mean follow-up period of 135.5 ± 4.7 months, the clinical symptoms in all patients improved by different degrees...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27990162/the-changes-of-serum-leptin-and-kisspeptin-levels-in-chinese-children-and-adolescents-in-different-pubertal-stages
#11
Hui Juan Zhu, Su Juan Li, Hui Pan, Naishi Li, Dian Xi Zhang, Lin Jie Wang, Hong Bo Yang, Qinyong Wu, Feng Ying Gong
The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P < 0...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27990161/sex-hormone-binding-globulin-modifies-testosterone-action-and-metabolism-in-prostate-cancer-cells
#12
Huika Li, Thy Pham, Brett C McWhinney, Jacobus P Ungerer, Carel J Pretorius, Derek J Richard, Robin H Mortimer, Michael C d'Emden, Kerry Richard
Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action. This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line. Internalisation of SHBG and testosterone, the effects of SHBG on testosterone uptake, metabolism, regulation of androgen responsive genes, and cell growth were assessed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27990160/the-roles-of-pi3k-akt-mtor-and-mapk-erk-signaling-pathways-in-human-pheochromocytomas
#13
Juan Du, Anli Tong, Fen Wang, Yunying Cui, Chunyan Li, Yushi Zhang, Zhaoli Yan
Objectives. The roles of PI3K/AKT/mTOR and MAPK/ERK pathways involved in the pathogenesis of pheochromocytoma and paraganglioma (PPGL) were demonstrated mostly by in vitro studies with rat or mouse cells and were mainly studied at transcriptional level. This study aimed to investigate the effect of these pathways on the proliferation of human PPGL cells and the activation of these pathways in PPGLs. Methods. Human PPGL cells were treated with sunitinib and inhibitors of PI3K (LY294002), MEK1/2 (U0126), and mTORC1/2 (AZD8055)...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27956899/body-composition-in-adult-patients-with-thalassemia-major
#14
Marianna Vlychou, Evangelos Alexiou, Paschalis Thriskos, Ioannis Fezoulidis, Katerina Vassiou
Objective. To assess body composition in adult male and female patients with thalassemia major by dual-energy X-ray absorptiometry (DXA) and to compare the findings with a group of healthy age-matched controls. Methods. Our study group included sixty-two patients (27 males, mean age 36 years, and 35 females, mean age 36.4 years) and fifteen age-matched healthy controls. All patients had an established diagnosis of thalassemia major and followed a regular blood transfusion scheme since childhood and chelation treatment...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27956898/association-between-sleep-duration-and-measurable-cardiometabolic-risk-factors-in-healthy-korean-women-the-fourth-and-fifth-korean-national-health-and-nutrition-examination-surveys-knhanes-iv-and-v
#15
Hyeyeon Min, Yoo Jin Um, Bum Sup Jang, Doosup Shin, EunJoo Choi, Sang Min Park, Kiheon Lee
Study Objectives. To examine the association between sleep duration and prevalence of metabolic syndrome (MetS) and its components in healthy Korean women. Design. Cross-sectional study, using the Fourth and Fifth Korean National Health and Nutrition Examination Surveys. Methods. Among 8505 women (25-70 years) from KNHANES IV and V, participants were classified into five sleep groups based on self-reported sleep duration. MetS and its components were defined using the criteria set forth in National Cholesterol Education Program-Adult Treatment Panel III...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27956897/gestational-diabetes-mellitus-and-future-cardiovascular-risk-an-update
#16
REVIEW
S Burlina, M G Dalfrà, N C Chilelli, A Lapolla
The prevalence of gestational diabetes mellitus is increasing in parallel with the rising prevalence of type 2 diabetes and obesity around the world. Current evidence strongly suggests that women who have had gestational diabetes mellitus are at greater risk of cardiovascular disease later in life. Given the growing prevalence of gestational diabetes mellitus, it is important to identify appropriate reliable markers of cardiovascular disease and specific treatment strategies capable of containing obesity, diabetes, and metabolic syndrome in order to reduce the burden of cardiovascular disease in the women affected...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27895666/cardiometabolic-risk-in-hyperlipidemic-men-and-women
#17
Michael Leutner, Christian Göbl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Jürgen Harreiter, Helmut Prosch, Oliver Schlager, Silvia Charwat-Resl, Alexandra Kautzky-Willer
Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR) was done. Results. HL-women were older and had favourable concentrations of high density lipoprotein cholesterol (HDL-cholesterol), triglycerides (TG), and triglyceride/HDL-cholesterol ratio (TG/HDL-ratio) but were also shown to have higher concentrations of lipoprotein-a compared to HL-men...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27882052/myoinositol-and-d-chiro-inositol-in-improving-insulin-resistance-in-obese-male-children-preliminary-data
#18
Mario Mancini, Alice Andreassi, Michela Salvioni, Fiore Pelliccione, Gianna Mantellassi, Giuseppe Banderali
Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. However, it has not been determined if this relationship exists also in children. Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. To evaluate this hypothesis, we administered both inositol formulations before carrying out an oral glucose tolerance test (OGTT) in a group of obese insulin-resistant male children with high basal insulin levels and compared the values obtained with an OGTT previously conducted without inositol, in the same group, with unchanged BMI...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27882051/glycated-hemoglobin-levels-in-patients-with-decompensated-cirrhosis
#19
Jeffrey Nadelson, Sanjaya K Satapathy, Satheesh Nair
Introduction. Aim of this study is to determine if HbA1c levels are a reliable predictor of glycemic control in patients with decompensated cirrhosis. Methods. 200 unique patients referred for liver transplantation at University of Tennessee/Methodist University Transplant Institute with a HbA1c result were included. Three glucose levels prior to the "measured" A1c (MA1c) were input into an HbA1c calculator from the American Diabetes Association website to determine the "calculated" A1c (CA1c). The differences between MA1c and CA1c levels were computed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27882050/thyroid-stimulating-hormone-is-increased-in-hypertensive-patients-with-obstructive-sleep-apnea
#20
Nanfang Li, Mulalibieke Heizhati, Chao Sun, Suofeiya Abulikemu, Liang Shao, Xiaoguang Yao, Yingchun Wang, Jing Hong, Ling Zhou, Lei Wang, Yu Zhang, Weiwei Zhang
Purpose. To evaluate alteration in serum TSH in hypertensives with OSA and its relation with cardiometabolic risk factors. Methods. 517 hypertensives were cross-sectionally studied. OSA was determined by polysomnography and thyroid function by standard methods. Results. OSA was diagnosed in 373 hypertensives (72.15%). Prevalence of subclinical hypothyroidism was significantly higher in OSA hypertensives than in non-OSA ones (15.0% versus 6.9%, P = 0.014). Serum LnTSH in hypertensives with severe OSA was significantly higher (0...
2016: International Journal of Endocrinology
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