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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/29780419/elevated-serum-total-bilirubin-concentrations-are-negatively-associated-with-diabetic-retinopathy-among-the-chinese-northeastern-population
#1
Dan Zhang, Wei Zhang, Shi Jin, Wei Wang, Dan Guo, Lu Wang
Objective: To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods: A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results: A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29780418/biological-and-clinical-effects-of-calciprotein-particles-on-chronic-kidney-disease-mineral-and-bone-disorder
#2
REVIEW
Kenichi Akiyama, Takaaki Kimura, Kazuhiro Shiizaki
Calciprotein particles (CPPs) are a new biological marker of chronic kidney disease-mineral and bone disorder (CKD-MBD). CPPs consist of phosphate, calcium, and some proteins, with phosphate being the major contributor to the level and biological activity of CPPs. Recent studies have shown the physiological and pathological significance of CPPs, including contributions to bone and mineral metabolism, and to tissue and organ impairments such as cardiovascular damage and inflammatory responses. These actions are well known as important aspects of CKD-MBD...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29780417/osteoporosis-is-associated-with-deteriorating-clinical-status-in-adults-with-cystic-fibrosis
#3
Inger Hee Mathiesen, Tacjana Pressler, Peter Oturai, Terese Lea Katzenstein, Marianne Skov, Ruth Frikke-Schmidt, Mette Friberg Hitz
Background: Cystic fibrosis (CF) patients are in increased risk of osteoporosis. We aimed to determine the osteoporosis prevalence in an adult CF cohort and investigate calcium metabolic parameters and clinical status' association with bone mineral density evaluated by dual X-ray absorptiometry scan. Methods: We performed a cross section database study of adults at a tertiary CF Center. Z scores were applied for patients < 50 years of age and T scores for patients > 50 years of age...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29780416/physiological-aldosterone-concentrations-are-associated-with-alterations-of-lipid-metabolism-observations-from-the-general-population
#4
M Hannich, H Wallaschofski, M Nauck, M Reincke, C Adolf, H Völzke, R Rettig, A Hannemann
Objective: Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29780415/comparison-of-efficacy-and-safety-of-lispro-and-aspart-evaluated-by-continuous-glucose-monitoring-system-in-patients-with-newly-diagnosed-type-2-diabetes
#5
Bing-Li Liu, Guo-Ping Yin, Feng-Fei Li, Yun Hu, Jin-Dan Wu, Mao-Yuan Chen, Lei Ye, Xiao-Fei Su, Jian-Hua Ma
Objective: To compare the effect of the rapid-acting insulin analogues (RAIAs) aspart (NovoRapid) and lispro (Prandilin) on glycemic variations by continuous glucose monitoring system (CGMS) in patients within newly diagnosed type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) and metformin intensive therapy. Methods: This is a single-blind randomized controlled trial. A total of 110 patients with newly diagnosed T2DM and with hemoglobin A1c (HbA1c%) above 9% was hospitalized and randomly divided into two groups: group Asp (NovoRapid group) and group Lis (Prandilin group)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29770148/clinical-characteristics-of-aldosterone-and-cortisol-coproducing-adrenal-adenoma-in-primary-aldosteronism
#6
Lu Tang, Xintao Li, Baojun Wang, Xin Ma, Hongzhao Li, Yu Gao, Liangyou Gu, Wenyuan Nie, Xu Zhang
Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People's Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs ( P < 0...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29765404/meta-analysis-of-the-association-between-vitamin-d-receptor-polymorphisms-and-the-risk-of-autoimmune-thyroid-disease
#7
Xue-Ren Gao, Yong-Guo Yu
The association between vitamin D receptor ( VDR ) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755524/a-clinical-roadmap-to-investigate-the-genetic-basis-of-pediatric-pheochromocytoma-which-genes-should-physicians-think-about
#8
REVIEW
Bernardo Dias Pereira, Tiago Nunes da Silva, Ana Teresa Bernardo, Rui César, Henrique Vara Luiz, Karel Pacak, Luísa Mota-Vieira
Pheochromocytoma is very rare at a pediatric age, and when it is present, the probability of a causative genetic mutation is high. Due to high costs of genetic surveys and an increasing number of genes associated with pheochromocytoma, a sequential genetic analysis driven by clinical and biochemical phenotypes is advised. The published literature regarding the genetic landscape of pediatric pheochromocytoma is scarce, which may hinder the establishment of genotype-phenotype correlations and the selection of appropriate genetic testing at this population...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755523/hypophyseal-involvement-in-immunoglobulin-g4-related-disease-a-retrospective-study-from-a-single-tertiary-center
#9
Yang Liu, Linjie Wang, Wen Zhang, Hui Pan, Hongbo Yang, Kan Deng, Lin Lu, Yong Yao, Shi Chen, Xiaofeng Chai, Feng Feng, Hui You, Zimeng Jin, Huijuan Zhu
This study aims to outline the clinical features and outcomes of IgG4-related hypophysitis (IgG4-RH) patients in a tertiary medical center. We reviewed clinical manifestations and imaging and pituitary function tests at baseline, as well as during follow-up. Ten patients were included. The mean age at diagnosis of IgG4-RH was 48.4 (16.0-64.0) years. An average of 3 (0-9) extrapituitary organs were involved. Five patients had panhypopituitarism, three had only posterior hypopituitarism, one had only anterior hypopituitarism, and one had a normal pituitary function...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755522/in-situ-preservation-fraction-of-parathyroid-gland-in-thyroidectomy-a-cohort-retrospective-study
#10
Han Luo, Wanjun Zhao, Hongliu Yang, Anping Su, Bin Wang, Jingqiang Zhu
Background and Objectives: Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods: Consecutive patients who underwent initial total thyroidectomy were enrolled retrospectively in a prospectively maintained database. Patients were divided into groups by parathyroid gland remaining in situ fraction (PGRIF) (PGRIF = number of in situ glands/(total number of identified glands - number of glands in specimen)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755521/cataract-as-early-ocular-complication-in-children-and-adolescents-with-type-1-diabetes-mellitus
#11
REVIEW
Marko Šimunović, Martina Paradžik, Roko Škrabić, Ivana Unić, Kajo Bućan, Veselin Škrabić
Cataract is a rare manifestation of ocular complication at an early phase of T1DM in the pediatric population. The pathophysiological mechanism of early diabetic cataract has not been fully understood; however, there are many theories about the possible etiology including osmotic damage, polyol pathway, and oxidative stress. The prevalence of early diabetic cataract in the population varies between 0.7 and 3.4% of children and adolescents with T1DM. The occurrence of diabetic cataract in most pediatric patients is the first sign of T1DM or occurs within 6 months of diagnosis of T1DM...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755520/efficacy-safety-and-quality-of-treatment-satisfaction-of-premixed-human-and-analogue-insulin-regimens-in-a-large-cohort-of-type-2-diabetic-patients-progens-benefit-observational-study
#12
Katarzyna Nabrdalik, Hanna Kwiendacz, Tomasz Sawczyn, Andrzej Tomasik, Michał Kukla, Małgorzata Masierek, Janusz Gumprecht
Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) in a real-life environment. 2493 patients (62.77%) had been assigned to group I where before the inclusion into the study the treatment regimen has been changed from analogue to human premixed insulin and 771 patients (37...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29755519/simulated-cholinergic-reinnervation-of-%C3%AE-ins-1-cells-antidiabetic-utility-of-heterotypic-pseudoislets-containing-%C3%AE-cell-and-cholinergic-cell
#13
Ao Jiao, Feng Li, Chengshuo Zhang, Wu Lv, Baomin Chen, Jialin Zhang
Cholinergic neurons can functionally support pancreatic islets in controlling blood sugar levels. However, in islet transplantation, the level of cholinergic reinnervation is significantly lower compared to orthotopic pancreatic islets. This abnormal reinnervation affects the survival and function of islet grafts. In this study, the cholinergic reinnervation of beta cells was simulated by 2D and 3D coculture of INS-1 and NG108-15 cells. In 2D culture conditions, 20 mM glucose induced a 1.24-fold increase ( p < 0...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29736170/susceptible-and-prognostic-genetic-factors-associated-with-diabetic-peripheral-neuropathy-a-comprehensive-literature-review
#14
REVIEW
L B L Prabodha, N D Sirisena, V H W Dissanayake
Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. It is the primary cause of diabetes-related hospital admissions and nontraumatic foot amputations. The pathogenesis of diabetic neuropathy is a complex process that involves hyperglycemia-induced oxidative stress and altered polyol metabolism that changes the nerve microvasculature, altered growth factor support, and deregulated lipid metabolism...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29736169/incidence-and-risk-factors-of-diabetic-foot-ulcer-a-population-based-diabetic-foot-cohort-adfc-study-two-year-follow-up-study
#15
Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Saeed Hesam
Aim/Introduction: This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU). Materials and Methods: In this prospective cohort study in a university hospital, all the participants were examined and followed up for new DFU as final outcome for two years. To analyze the data, the variables were first evaluated with a univariate analysis. Then variables with P value < 0.2 were tested with a multivariate analysis, using backward-elimination multiple logistic regression...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29721019/establishing-differences-in-thermographic-patterns-between-the-various-complications-in-diabetic-foot-disease
#16
Alfred Gatt, Owen Falzon, Kevin Cassar, Christian Ellul, Kenneth P Camilleri, Jean Gauci, Stephen Mizzi, Anabelle Mizzi, Cassandra Sturgeon, Liberato Camilleri, Nachiappan Chockalingam, Cynthia Formosa
Aim: To evaluate the potential of thermography as an assessment tool for the detection of foot complications by understanding the variations in temperature that occur in type 2 diabetes mellitus (DM). Methods: Participants were categorized according to a medical examination, ankle brachial index, doppler waveform analysis, and 10-gram monofilament testing into five groups: healthy adult, DM with no complications, DM with peripheral neuropathy, DM with neuroischaemia, and DM with peripheral arterial disease (PAD) groups...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29721018/efficacy-and-safety-of-insulin-degludec-versus-insulin-glargine-a-systematic-review-and-meta-analysis-of-fifteen-clinical-trials
#17
REVIEW
Wei Liu, Xiaojie Yang, Jing Huang
Aims: Insulin degludec (IDeg) and insulin glargine (IGlar) are both proved to be effective in diabetes. This study aimed to assess the effects and safety of IDeg versus IGlar. Methods: A systematic literature search was conducted using the PubMed, EMBASE, and Cochrane Library electronic databases to identify all randomized controlled trials (RCTs). Results: Fifteen RCTs were identified. The combined data showed that the decrease in the glycosylated hemoglobin (HbA1c) level was slightly different, and the proportion of patients who achieved HbA1c < 7% was similar between the IDeg and IGlar groups...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29721017/elevated-and-correlated-expressions-of-mir-24-mir-30d-mir-146a-and-sfrp-4-in-human-abdominal-adipose-tissue-play-a-role-in-adiposity-and-insulin-resistance
#18
Yury O Nunez Lopez, Gabriella Garufi, Magdalena Pasarica, Attila A Seyhan
Objective: We explored the relationships among microRNAs (miRNAs) and SFRP4, as they relate to adipose tissue functions including lipolysis, glucose and glycerol turnover, and insulin sensitivity. Methods: Abdominal adipose tissue (AbdAT) levels of thirteen microRNAs (miRNAs), SFRP4, and VEGF in lean nondiabetic subjects ( n = 7), subjects with obesity ( n = 5), and subjects with obesity and type 2 diabetes (T2DM) ( n = 5) were measured by qPCR. Insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29721016/the-association-of-thyroid-nodules-with-metabolic-status-a-cross-sectional-spect-china-study
#19
Yi Chen, Chunfang Zhu, Yingchao Chen, Ningjian Wang, Qin Li, Bing Han, Li Zhao, Chi Chen, Hualing Zhai, Yingli Lu
Purpose: The aim of this study was to investigate the association of thyroid nodules (TNs) and their ultrasound (US) characteristics related to malignancy with metabolic status. Methods: The data were obtained from a cross-sectional study (SPECT-China, 2014-2015). The study included 9898 participants older than 18 years. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, TSH levels, glucose, and lipid profiles...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29721015/a-comparative-assessment-of-cardiovascular-autonomic-reflex-testing-and-cardiac-123-i-metaiodobenzylguanidine-imaging-in-patients-with-type-1-diabetes-mellitus-without-complications-or-cardiovascular-risk-factors
#20
Triantafyllos Didangelos, Efstratios Moralidis, Eleni Karlafti, Konstantinos Tziomalos, Charalambos Margaritidis, Zisis Kontoninas, Ioannis Stergiou, Maria Boulbou, Marianthi Papagianni, Emmanouel Papanastasiou, Apostolos I Hatzitolios
Aim: To compare the cardiovascular autonomic reflex tests (CARTs) with cardiac sympathetic innervation imaging with 123 I-metaiodobenzylguanidine (MIBG) in patients with type 1 diabetes mellitus (T1DM). Patients and Methods: Forty-nine patients (29 males, mean age 36 ± 10 years, mean T1DM duration 19 ± 6 years) without cardiovascular risk factors were prospectively enrolled. Participants were evaluated for autonomic dysfunction by assessing the mean circular resultant (MCR), Valsalva maneuver (Vals), postural index (PI), and orthostatic hypotension (OH)...
2018: International Journal of Endocrinology
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