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International Journal of Endocrinology

Nuha Alwardat, Laura Di Renzo, Antonino De Lorenzo
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
Solhild Stridsklev, Øyvind Salvesen, Kjell Åsmund Salvesen, Sven M Carlsen, Eszter Vanky
The objective of this study was to investigate possible differences in uterine artery pulsatility index (UtAPI) between pregnant women with PCOS and healthy controls and to explore possible effects of metformin on UtAPI. Material and Methods . The study was conducted in a tertiary center. Forty-eight pregnant women diagnosed with PCOS before pregnancy and 124 healthy pregnant women were included. Women with PCOS were randomly assigned to metformin 2000 mg daily or a placebo. UtAPI was measured five times during 1st and 2nd trimesters of pregnancy in women with PCOS and four times in healthy controls...
2018: International Journal of Endocrinology
V B Matthews, R Hollingshead, H Koch, K D Croft, N C Ward
Background: Nitric oxide (NO) is an important vascular signaling molecule that plays a role in vascular homeostasis. A reduction in NO bioavailability is thought to contribute to endothelial dysfunction, an early risk factor for both cardiovascular disease and type 2 diabetes. Dietary nitrate, through the nitrate-nitrite-NO pathway, may provide an alternate source of NO when the endogenous eNOS system is compromised. In addition to a role in the vascular system, NO may also play a role in the metabolic syndrome including obesity and glucose tolerance...
2018: International Journal of Endocrinology
Natalia Elvira Poveda, María Fernanda Garcés, Aquiles Enrique Darghan, Silvia Alejandra Blanco Jaimes, Estefania Pulido Sánchez, Luz Amparo Díaz-Cruz, Carmen Doris Garzón-Olivares, Mario Orlando Parra-Pineda, Alejandro Antonio Bautista-Charry, Edith Ángel Müller, Héctor Fabio Sandoval Alzate, Luis Miguel Maldonado Acosta, Elizabeth Sanchez, Ariel Iván Ruíz-Parra, Jorge Eduardo Caminos
Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant ( n = 142), preeclamptic ( n = 18), and healthy nonpregnant women ( n = 56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c ( p < 0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women...
2018: International Journal of Endocrinology
Andrea Sansone, Angelo Cignarelli, Massimiliano Sansone, Francesco Romanelli, Giovanni Corona, Daniele Gianfrilli, Andrea Isidori, Francesco Giorgino, Andrea Lenzi
Objectives: Elevated levels of serum homocysteine (Hcy) have been associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). This meta-analysis was aimed to assess serum Hcy levels in subjects with ED compared to controls in order to clarify the role of Hcy in the pathogenesis of ED. Methods: Medline, Embase, and the Cochrane Library were searched for publications investigating the possible association between ED and Hcy...
2018: International Journal of Endocrinology
Michael Leutner, Christian Göbl, Peter Wolf, Katharina Maruszczak, Latife Bozkurt, Helmut Steinbrecher, Ivica Just-Kukurova, Johannes Ott, Christian Egarter, Siegfried Trattnig, Alexandra Kautzky-Willer
Objective: The objective of the present study is to investigate the relationship of cardiac fat depots with disturbances of the carbohydrate metabolism in women with PCOS. Methods: An oral glucose tolerance test (OGTT) was realized, and metabolic parameters were collected in 48 women with PCOS and in 20 controls. Intramyocardial fat (MYCL) and pericardial fat (PERI) were measured using 1 H-magnetic resonance spectroscopy and imaging. Results: Only in PCOS women, PERI was positively and independently related to parameters of glucose metabolism (HbA1c: p = 0...
2018: International Journal of Endocrinology
Xi Chen, Xiaohong Kong, Jie Zhu, Tingting Zhang, Yanwei Li, Guifeng Ding, Huijuan Wang
Objective: Thyroid dyshormonogenesis (DH) is a genetically heterogeneous inherited disorder caused by thyroid hormone synthesis abnormalities. This study aims at comprehensively characterizing the mutation spectrum in Chinese patients with DH. Subjects and Methods: We utilized next-generation sequencing to screen for mutations in seven DH-associated genes (TPO, DUOX2, TG, DUOXA2, SLC26A4, SLC5A5, and IYD) in 21 Chinese Han patients with DH from Xinjiang Province...
2018: International Journal of Endocrinology
Hussam H Alhawari, Yousef S Khader, Hussein H Alhawari, Amal F Alomari, Hiba N Abbasi, Muhannd S El-Faouri, Muawyah D Al Bdour
Purpose: The association between autoimmune diseases and keratoconus (KC) has been proposed based on previous retrospective studies and case reports. The aim of our study is to investigate whether KC is associated with autoimmune thyroid disease . Methods. A comparative study was conducted on 131 adult subjects from September 2015 to May 2017 at Jordan University Hospital, Amman, Jordan. Subjects were classified into 2 groups: subjects with autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis ( n = 68), and a healthy group for comparison ( n = 63)...
2018: International Journal of Endocrinology
Francisco J Valenzuela-Melgarejo, Claudia Caro-Díaz, Gerardo Cabello-Guzmán
Increased consumption of energy-dense foods such as fructose-rich syrups represents one of the significant, growing concerns related to the alarming trend of overweight, obesity, and metabolic disorders worldwide. Metabolic pathways affected by fructose involve genes related to lipogenesis/lipolysis, beta-oxidation, mitochondrial biogenesis, gluconeogenesis, oxidative phosphorylation pathways, or altering of circadian production of insulin and leptin. Moreover, fructose can be a risk factor during pregnancy elevating the risk of preterm delivery, hypertension, and metabolic impairment of the mother and fetus...
2018: International Journal of Endocrinology
Edna Berzabá-Evoli, Cecilia Zazueta, Jarumi Hishel Cruz Hernández, Nancy Patricia Gómez-Crisóstomo, Isela Esther Juárez-Rojop, Erick Natividad De la Cruz-Hernández, Eduardo Martínez-Abundis
Background: Functional receptors for leptin were described on the surface of cardiomyocytes, and there was a prohypertrophic effect with high concentrations of the cytokine. Therefore, leptin could be a link between obesity and the prevalence of cardiovascular diseases. On the other hand, a deleterious effect of leptin on mitochondrial performance was described, which was also associated with the evolution of cardiac hypertrophy to heart failure. The goal of our study was to analyze the effect of the exposure of rat hearts to a high concentration of leptin on cardiac and mitochondrial function...
2018: International Journal of Endocrinology
Shital Julania, Melanie L Walls, Roger Hart
In vitro maturation (IVM) of human oocytes is an emerging treatment option for women with polycystic ovary/polycystic ovary syndrome (PCO/PCOS) in addition to the standard in vitro fertilization (IVF) treatment. There has been significant improvements in pregnancy rates with IVM over the last two decades. This article reviews the place of IVM for women with PCO/PCOS, placing an emphasis on the predictors of successful pregnancy, optimization of culture media, IVM protocols, pregnancy rates, and neonatal outcomes following IVM treatment...
2018: International Journal of Endocrinology
So-Hyeon Hong, Hyejin Lee, Min-Sun Cho, Jee Eun Lee, Yeon-Ah Sung, Young Sun Hong
Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in thyroid fine needle aspiration (FNA) is a challenging category. The malignancy risk is different by multiple factors and subsequent management strategy is inconclusive. Therefore, we analyzed the malignancy risk of AUS/FLUS according to radiological and clinical features. A total of 687 nodules that had been initially diagnosed as AUS/FLUS were retrospectively reviewed from 6365 thyroid FNAs between 2011 and 2014...
2018: International Journal of Endocrinology
Yanmei Yang, Bin Wang
Metastatic breast cancer (BrCa) is currently incurable despite great improvements in treatment of primary BrCa. The incidence of skeletal metastases in advanced BrCa occurs up to 70%. Recent findings have established that the distribution of BrCa metastases to the skeleton is not a random process but due to the favorable microenvironment for tumor invasion and growth. The complex interplay among BrCa cells, stromal/osteoblastic cells, and osteoclasts in the osseous microenvironment creates a bone-tumor vicious cycle (a feed-forward loop) that results in excessive bone destruction and progressive tumor growth...
2018: International Journal of Endocrinology
Da-Zhi Chen, Qiao-Mai Xu, Xiao-Xin Wu, Chao Cai, Ling-Jian Zhang, Ke-Qing Shi, Hong-Ying Shi, Lan-Juan Li
The present study evaluated the potential combined effects of NAFLD and MetS on the development of osteoporosis. The relationship between NAFLD and MetS and osteoporosis was assessed in 938 postmenopausal female participants. Moderate and severe NAFLDs were combined as significant NAFLD (SNAFLD). All the subjects were divided into 4 subgroups based on the status of SNAFLD and MetS. Relative excess risk of interaction (RERI), attributable proportion (AP) of interaction, and synergy index (SI) were used to investigate the additive interaction of those two factors...
2018: International Journal of Endocrinology
Yongwen Zhang, Lanfang Chu
Background: Health education is considered to be essential in the overall care of patients with type 2 diabetes mellitus (T2DM); systematic health education integrates individual education not only during hospitalization but also extended care outside of a hospital. To test effectiveness of the systematic health education model for T2DM, we conducted a randomized study with a control group among patients with T2DM living in Nanjing, China. Methods: 998 eligible patients completed the enrollment and were randomized to systematic health education model and conventional model groups (498 and 500 patients, resp...
2018: International Journal of Endocrinology
Agnieszka Zachurzok, Agnieszka Pasztak-Opilka, Elzbieta Forys-Dworniczak, Agnieszka Drosdzol-Cop, Aneta Gawlik, Ewa Malecka-Tendera
Study Objective: The objective of this study was to evaluate whether body weight status and clinical hyperandrogenism may influence social competencies and psychological gender features in adolescent girls. Design and Participants: In 104 adolescent girls, psychological gender inventory (PGI) and social competencies questionnaire (SCQ) (assessing social abilities in three aspects: intimacy (I), social exposure (SE), and assertiveness (AS)) were performed. Subjects were divided into four subgroups: G1-24 nonobese girls without hyperandrogenism, G2-18 obese girls without hyperandrogenism, G3-30 nonobese hyperandrogenic girls, and G4-32 obese girls with hyperandrogenism...
2018: International Journal of Endocrinology
Eduardo Spinedi, Daniel P Cardinali
Polycystic ovary syndrome is a highly frequent reproductive-endocrine disorder affecting up to 8-10% of women worldwide at reproductive age. Although its etiology is not fully understood, evidence suggests that insulin resistance, with or without compensatory hyperinsulinemia, and hyperandrogenism are very common features of the polycystic ovary syndrome phenotype. Dysfunctional white adipose tissue has been identified as a major contributing factor for insulin resistance in polycystic ovary syndrome. Environmental (e...
2018: International Journal of Endocrinology
Yang-Ming Yang, Pravin B Sehgal
The "estrogen paradox" in pulmonary arterial hypertension (PAH) refers to observations that while there is a higher incidence of idiopathic PAH in women, rodent models of PAH show male dominance and estrogens are protective. To explain these differences, we previously proposed the neuroendocrine-STAT5-BCL6 hypothesis anchored in the sex-biased and species-specific patterns of growth hormone (GH) secretion by the pituitary, the targeting of the hypothalamus by estrogens to feminize GH secretion patterns, and the role of the transcription factors STAT5a/b and BCL6 as downstream mediators of this patterned GH-driven sex bias...
2018: International Journal of Endocrinology
Guido Sebastiani, Claudiane Guay, Mathieu Latreille
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
Lakshini Y Herat, Vance B Matthews, P Elizabeth Rakoczy, Revathy Carnagarin, Markus Schlaich
The prevalence of diabetes is at pandemic levels in today's society. Microvascular complications in organs including the eye are commonly observed in human diabetic subjects. Diabetic retinopathy (DR) is a prominent microvascular complication observed in many diabetics and is particularly debilitating as it may result in impaired or complete vision loss. In addition, DR is extremely costly for the patient and financially impacts the economy as a range of drug-related therapies and laser treatment may be essential...
2018: International Journal of Endocrinology
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