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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/28642791/efficacy-and-safety-of-ultrasound-guided-percutaneous-polidocanol-sclerotherapy-in-benign-cystic-thyroid-nodules-preliminary-results
#1
Xiaohua Gong, Qi Zhou, Fang Wang, Wenjun Wu, Xiaojun Chen
OBJECTIVE: To evaluate the efficacy and safety of percutaneous polidocanol injection (PPI) in treating cystic thyroid nodules. MATERIALS AND METHODS: A total of 158 cystic or predominantly cystic thyroid nodules (>80% cystic component) in 143 patients were evaluated. 114 patients with compressive symptoms or aesthetic complaints were offered PPI. 44 individuals without compressive symptoms and aesthetic complaints who were only followed up clinically were used as the control group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28642790/therapeutic-outcomes-of-patients-with-multifocal-papillary-thyroid-microcarcinomas-and-larger-tumors
#2
Soh-Ching Ng, Sheng-Fong Kuo, Szu-Tah Chen, Chuen Hsueh, Bie-Yu Huang, Jen-Der Lin
A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinical features between 626 multifocal and 1,910 solitary PTC cases showed that patients in the multifocal PTC group were older and had a smaller mean tumor size, a more advanced tumor-node-metastasis (TNM) stage, and a higher percentage of nonremission status compared to patients in the solitary PTC group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28642789/androgen-receptor-localizes-to-plasma-membrane-by-binding-to-caveolin-1-in-mouse-sertoli-cells
#3
Qiong Deng, Yong Wu, Zeng Zhang, Yue Wang, Minghua Li, Hui Liang, Yaoting Gui
The nonclassical androgen signaling pathway translates signals into alterations in cellular function within minutes, and this action is proposed to be mediated by an androgen receptor (AR) localized to the plasma membrane. This study was designed to determine the mechanism underlying the membrane association of androgen receptor in TM4 cells, a mouse Sertoli cell line. Western blot analysis indicated testosterone-induced AR translocation to the cell membrane. Data from coimmunoprecipitation indicated that AR is associated with caveolin-1, and testosterone enhanced this association...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28638409/differential-fasting-plasma-glucose-and-ketone-body-levels-in-ghrko-versus-3xtg-ad-mice-a-potential-contributor-to-aging-related-cognitive-status
#4
Chelsea M Griffith, Lauren N Macklin, Andrzej Bartke, Peter R Patrylo
Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased ketone body (KB) levels in the brain. Since the majority of brain nutrients come from the periphery, this study examined whether the capacity to regulate peripheral glucose levels and KB production differs in animals with successful cognitive aging (growth hormone receptor knockouts, GHRKOs) versus unsuccessful cognitive aging (the 3xTg-AD mouse model of Alzheimer's disease)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28638408/reanalysis-and-external-validation-of-a-decision-tree-model-for-detecting-unrecognized-diabetes-in-rural-chinese-individuals
#5
Zhong Xin, Lin Hua, Xu-Hong Wang, Dong Zhao, Cai-Guo Yu, Ya-Hong Ma, Lei Zhao, Xi Cao, Jin-Kui Yang
We reanalyzed previous data to develop a more simplified decision tree model as a screening tool for unrecognized diabetes, using basic information in Beijing community health records. Then, the model was validated in another rural town. Only three non-laboratory-based risk factors (age, BMI, and presence of hypertension) with fewer branches were used in the new model. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) for detecting diabetes were calculated...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28638407/the-proline-7-substitution-in-the-preproneuropeptide-y-is-associated-with-higher-hepatic-lipase-activity-in-vivo
#6
Stephan Schiekofer, Marcus E Kleber, Winfried Maerz, Franz M Rasche, Jochen G Schneider
Hepatic lipase (HL) functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins. Plasma HL activity is known to be regulated by hormonal and metabolic factors, but HL responsiveness to insulin as well as its role in modulating atherosclerotic risk is still controversial. We investigated on the influence of a known polymorphism in the neurotransmitter neuropeptide Y (NPY) on HL activity in two different cohorts consisting of diabetic and nondiabetic patients...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28634491/more-favorable-metabolic-impact-of-three-times-weekly-versus-daily-growth-hormone-treatment-in-na%C3%A3-ve-gh-deficient-children
#7
Alessandro Ciresi, Floriana Cicciò, Stefano Radellini, Valentina Guarnotta, Anna Maria Calcaterra, Carla Giordano
OBJECTIVE: To evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with growth hormone deficiency (GHD). DESIGN: 32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, 16 patients) or TIW (group B, 16 patients) GHT for 12 months. METHODS: Auxological parameters, insulin-like growth factor-I (IGF-I), glucose and insulin during OGTT, glycosylated hemoglobin (HbA1c), lipid profile, the oral disposition index (DIo), the homeostasis model assessment estimate of insulin resistance (Homa-IR), and the insulin sensitivity index (ISI)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28607554/lower-extremity-peripheral-arterial-disease-is-an-independent-predictor-of-coronary-heart-disease-and-stroke-risks-in-patients-with-type-2-diabetes-mellitus-in-china
#8
Xiao-Hong Pang, Jue Han, Wan-Lan Ye, Xue Sun, Yue Ding, Wen-Juan Huang, Yi-Ming Zhao, Han-Yu Lou, Li-Zhen Shan, Ying-Xiu Kang, Xiao-Xiao Song, Song-Zhao Zhang, Wei Gu, Peng-Fei Shan
We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index ≤ 0.9 or >1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index > 0.9 and ≤1.4; 1090 patients, 92.5%). Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P < 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28596789/relationship-between-igf-i-concentration-and-metabolic-profile-in-children-with-growth-hormone-deficiency-the-influence-of-children-s-nutritional-state-as-well-as-the-ghrelin-leptin-adiponectin-and-resistin-serum-concentrations
#9
Renata Stawerska, Joanna Smyczyńska, Maciej Hilczer, Andrzej Lewiński
BACKGROUND: Some, however not all, children with growth hormone deficiency (GHD) reveal a tendency towards metabolic disorders. Insulin-like growth factor I (IGF-I) is the main mediator of GH anabolic effects. OBJECTIVE: The aim of the study was to compare ghrelin, adiponectin, leptin, resistin, lipid, glucose, and insulin concentrations in GHD children, depending on the IGF-I bioavailability. METHODS: The analysis comprised 26 children with GHD, aged 5...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28592969/corrigendum-to-pharmacogenetics-of-risperidone-and-cardiovascular-risk-in-children-and-adolescents
#10
Amilton Dos Santos-Júnior, Taciane Barbosa Henriques, Maricilda Palandi de Mello, Osmar Henrique Della Torre, Lúcia Arisaka Paes, Adriana Perez Ferreira-Neto, Letícia Esposito Sewaybricker, Thiago Salum Fontana, Eloisa Helena Rubello Valler Celeri, Gil Guerra-Júnior, Paulo Dalgalarrondo
[This corrects the article DOI: 10.1155/2016/5872423.].
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28588615/relationship-between-central-arterial-stiffness-and-insulin-resistance-in-chinese-community-dwelling-population-without-diabetes-mellitus
#11
Shihui Fu, Ying Lin, Leiming Luo, Ping Ye
OBJECTIVE: Insulin resistance (IR) is a pathological condition present not only in patients with type 2 diabetes mellitus (DM), but also in community-dwelling population without DM. Both central arterial stiffness and IR are closely correlated with cardiovascular morbidity and mortality. The relationship between central arterial stiffness and IR has not been described in Chinese community-dwelling population without DM. The current analysis was designed to investigate the relationship between central arterial stiffness and IR in Chinese community-dwelling population without DM...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28572821/association-of-baseline-neutrophil-to-lymphocyte-ratio-with-clinicopathological-characteristics-of-papillary-thyroid-carcinoma
#12
Dimitrios K Manatakis, Sofia Tseleni-Balafouta, Dimitrios Balalis, Vasiliki N Soulou, Dimitrios P Korkolis, George H Sakorafas, Georgios Plataniotis, Emmanouil Gontikakis
OBJECTIVE: To investigate the potential association of neutrophil-to-lymphocyte ratio (NLR), a surrogate systemic inflammatory biomarker, with clinical and pathological characteristics of papillary thyroid cancers. METHODS: 205 patients with papillary carcinoma were identified from the institutional thyroid cancer database between 2006 and 2015 (55 males, 150 females, mean age 51.2 ± 14.7 years). NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count, based on the preoperative complete blood cell counts...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28572820/tsh-variability-of-patients-affected-by-differentiated-thyroid-cancer-treated-with-levothyroxine-liquid-solution-or-tablet-form
#13
Carlo Cappelli, Ilenia Pirola, Elena Gandossi, Claudio Casella, Davide Lombardi, Barbara Agosti, Fiorella Marini, Andrea Delbarba, Maurizio Castellano
BACKGROUND: Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with liquid L-T4 formulation or in tablet form. PATIENTS AND METHODS: Patients were eligible if (a) they were submitted to a total thyroidectomy and (131)I remnant ablation for DTC in our institution and (b) they were classified low-risk patients according to ATA guidelines 2009...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28572819/the-validity-and-reliability-between-automated-oscillometric-measurement-of-ankle-brachial-index-and-standard-measurement-by-eco-doppler-in-diabetic-patients-with-or-without-diabetic-foot
#14
Jing Ma, Min Liu, Dawei Chen, Chun Wang, Guanjian Liu, Xingwu Ran
OBJECTIVE: To evaluate the concordance between oscillometric ABI and standard Doppler ABI in diabetic Chinese patients with or without diabetic foot. METHODS: 230 consecutive diabetic patients (n = 459 limbs) were included. The right and left ABIs were determined with both devices by the same investigator. The concordance and agreement were assessed by kappa index and the Bland-Altman method. RESULTS: The average Doppler ABI was 1.003 ± 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28555155/review-of-factors-related-to-the-thyroid-cancer-epidemic
#15
REVIEW
Yihao Liu, Lei Su, Haipeng Xiao
Thyroid cancer is the most common endocrine cancer, of which the incidence has dramatically increased worldwide in the past few decades. The reasons for the observed rapid increase still are not fully understood, but evidence suggests that overdiagnosis, with the advancement in detection methods and screening policies, is not the sole driver of the substantial increase of the incidence. However, the effect of environmental/lifestyle factors remains speculative other than that of radiation exposure at a young age...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28529525/melatonin-in-tuberous-sclerosis-complex-analysis-using-modern-mathematical-modeling-methods
#16
Justyna Paprocka, Marek Kijonka, Łukasz Boguszewicz, Maria Sokół
Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n = 76) and the children from the control, nonepileptic group (n = 36)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28529524/antithyroid-drug-therapy-for-graves-disease-and-implications-for-recurrence
#17
REVIEW
Jia Liu, Jing Fu, Yuan Xu, Guang Wang
Graves' disease (GD) is the most common cause of hyperthyroidism worldwide. Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy. ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures. However, the relatively high recurrence rate is a major concern for ATD treatment, which is associated with multiple influencing factors like clinical characteristics, treatment strategies, and genetic and environmental factors...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28523069/crosstalk-between-aryl-hydrocarbon-receptor-and-glucocorticoid-receptor-in-human-retinal-pigment-epithelial-cells
#18
Hong Lan Jin, Yujin Choi, Kwang Won Jeong
The aryl hydrocarbon receptor (AHR) is known to mediate the cellular reaction involved in processing environmental contaminants and, ultimately, preventing accumulation of unfavorable extra lipids and proteins. Glucocorticoid receptor (GR) mediates the expression of genes associated with anti-inflammatory properties. Because AHR and GR are closely related in lipid metabolic dysregulation and inflammation, we speculate that AHR and GR may play a crucial role in AMD pathogenesis and focus on their crosstalk in human retinal pigment epithelial cells (ARPE-19)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28487736/synergistic-effect-of-family-history-of-diabetes-and-dietary-habits-on-the-risk-of-type-2-diabetes-in-central-china
#19
Yanyan Zhao, Chunhua Song, Xiaokun Ma, Xiaojun Ma, Qingzhu Wang, Hongfei Ji, Feng Guo, Guijun Qin
Background. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods. This was a cross-sectional survey in central urban China (n = 1234 patients with T2DM and n = 8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index (S) scores...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28487735/variations-in-the-3-utr-of-the-cyp21a2-gene-in-heterozygous-females-with-hyperandrogenaemia
#20
Vassos Neocleous, Pavlos Fanis, Meropi Toumba, Alexia A P Phedonos, Michalis Picolos, Elena Andreou, Tassos C Kyriakides, George A Tanteles, Christos Shammas, Leonidas A Phylactou, Nicos Skordis
Heterozygosity for CYP21A2 mutations in females is possibly related to increased risk of developing clinical hyperandrogenism. The present study was designed to seek evidence on the phenotype-genotype correlation in female children, adolescents, and women with CYP21A2 mutations and variants in the 3'UTR region of the gene. Sixty-six patients out of the 169 were identified as carriers of CYP21A2 mutations. Higher values of stimulated 17 hydroxyprogesterone (17-OHP) levels were found in the carriers of the p...
2017: International Journal of Endocrinology
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