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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/29158735/correlation-between-insulin-resistance-and-thyroid-nodule-in-type-2-diabetes-mellitus
#1
Yunzhao Tang, Tiantian Yan, Gang Wang, Yijun Chen, Yanjuan Zhu, Zhenhuan Jiang, Min Yang, Chenguang Li, Zhu Li, Ping Yu, Shanshan Wang, Nannan Zhu, Qiuyue Ren, Changlin Ni
Objective: The present study explored the association between insulin resistance (IR) and the clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM). Methods: All the patients were newly diagnosed with T2DM. 201 patients with thyroid nodule disease and 308 patients without the nodular thyroid disease. The participants were evaluated by relevant examination. Correlation analyses and regression analyses were performed to examine the relationships between the two groups...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29147113/clinical-presentation-management-and-outcomes-of-primary-hyperparathyroidism-during-pregnancy
#2
Ya Hu, Ming Cui, Zhengyi Sun, Zhe Su, Xiang Gao, Quan Liao, Yupei Zhao
Background: Primary hyperparathyroidism (pHPT) in pregnancy is a rare event, but it poses a significant risk to mothers and fetuses. The optimal treatment strategy remains controversial. Methods: We present a consecutive series of twelve pregnant women with pHPT. Results: Twelve women were diagnosed with pHPT during pregnancy or in the postpartum period. Four of them presented no symptoms or mild symptoms. Four patients experienced serious complications, including hypercalcaemic crisis, acute pancreatitis, and eclampsia...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29138634/the-synergistic-interplay-between-vitamins-d-and-k-for-bone-and-cardiovascular-health-a-narrative-review
#3
REVIEW
Adriana J van Ballegooijen, Stefan Pilz, Andreas Tomaschitz, Martin R Grübler, Nicolas Verheyen
Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29138633/influence-of-spk-with-enteric-drainage-on-the-pancreatic-exocrine-function-in-diabetic-patients-with-uremia
#4
Guanghui Pei, Wu Lv, Xiaohang Li, Guoqing Zhang, Jialin Zhang
Objective: This study aimed to determine the use of fecal elastase in evaluating the effect of simultaneous pancreas-kidney transplantation with enteric drainage on the pancreatic exocrine function of diabetic patients with uremia. Methods: A total of 19 patients with simultaneous pancreas-kidney transplantation (SPK) with enteric drainage, 31 diabetic patients with uremia (chronic renal failure (CRF)), 22 diabetic patients with uremia who underwent renal transplantation (RT), and 20 normal individuals (CON) were included in the study...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29118812/pde5-overexpression-in-well-differentiated-thyroid-carcinomas-is-associated-with-lymph-node-metastasis
#5
Ning Zhang, Zeng Fang, Qiufang Li, Kebing Wang, Songqi Li, Wen Li, Shenming Wang
Overexpression of PDE5 is observed in certain human cancers, but PDE5 expression in well-differentiated thyroid carcinoma (WDTC) is unknown. We therefore examined PDE5 expression and its relationship with the clinicopathological features of WDTC. Real-time qPCR and Western blotting were performed to analyze the expression of PDE5 mRNA and protein in paired WDTC tumor and adjacent nontumor tissues. Immunohistochemistry was used to analyze the expression of PDE5 in paraffin-embedded tissues obtained from 103 cases of WDTC...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29118811/obese-children-with-metabolic-syndrome-have-3-times-higher-risk-to-have-nonalcoholic-fatty-liver-disease-compared-with-those-without-metabolic-syndrome
#6
Dimitrios Papandreou, Mirey Karavetian, Zacharoula Karabouta, Eleni Andreou
Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29109738/association-between-sex-hormone-and-blood-uric-acid-in-male-patients-with-type-2-diabetes
#7
Wen Cao, Ren-Dong Zheng, Shu-Hang Xu, Yao-Fu Fan, Hong-Ping Sun, Chao Liu
The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29109737/associations-of-salivary-bpifa1-protein-in-chronic-periodontitis-patients-with-type-2-diabetes-mellitus
#8
Yue Guo, Lin-Na Guo, Jun-Fei Zhu, Chen-Yi Tang, Yun-Zhi Feng, Hou-De Zhou
Aims: To explore the differences in salivary BPI fold containing family A, member 1 (BPIFA1) concentration among type 2 diabetes mellitus (T2DM) subjects with various severities of chronic periodontitis and to determine whether BPIFA1 in saliva can be used as a potential biomarker of T2DM. Methods: Unstimulated saliva samples were collected from 44 subjects with T2DM and 44 without T2DM (NDM). Additionally, demographic data and general health parameters, including fasting blood glucose (FBG) and body mass index (BMI), were collected...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29104592/comparative-agreement-analysis-of-differences-in-1-5-anhydroglucitol-glycated-albumin-and-glycated-hemoglobin-a1c-levels-between-fasting-and-postprandial-states-in-steamed-bread-meal-test
#9
Hang Su, Yufei Wang, Xiaojing Ma, Xingxing He, Lingwen Ying, Junling Tang, Lu Dong, Yuqian Bao, Jian Zhou, Weiping Jia
Background: Our previous study indicated that serum 1,5-anhydroglucitol (1,5-AG) levels slightly increased after a glucose load; therefore, this study was conducted to explore short-term changes in 1,5-AG levels after a steamed bread meal test (SBMT) and compare the agreement of 1,5-AG, glycated albumin (GA), and glycated hemoglobin A1c (HbA1c) levels between fasting and postprandial states after an SBMT. Methods: 104 participants were recruited and underwent a 100 g SBMT...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29104591/melatonin-as-an-anti-inflammatory-agent-modulating-inflammasome-activation
#10
REVIEW
Gaia Favero, Lorenzo Franceschetti, Francesca Bonomini, Luigi Fabrizio Rodella, Rita Rezzani
Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29093737/novel-and-simple-ultrasonographic-methods-for-estimating-the-abdominal-visceral-fat-area
#11
Takeharu Asano, Naoto Kubota, Norihiro Koizumi, Kazunori Itani, Tsuyoshi Mitake, Kazuhito Yuhashi, Hongen Liao, Mamoru Mitsuishi, Shigemi Takeishi, Toshiaki Takahashi, Shin Ohnishi, Shiro Sasaki, Ichiro Sakuma, Takashi Kadowaki
Objectives: To evaluate the abdominal visceral fat area (VFA), we developed novel ultrasonographic (US) methods for estimating. Methods: 100 male volunteers were recruited, and their VFA was calculated by two novel US methods, the triangle method and the ellipse method. The VFA calculated by these methods was compared with the VFA calculated by CT. Results: Both the VFA calculated by the triangle method (r = 0.766, p < 0.001) and the ellipse method (r = 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29085428/pretreatment-bmi-is-associated-with-aggressive-clinicopathological-features-of-papillary-thyroid-carcinoma-a-multicenter-study
#12
Shi-Tong Yu, Wanzhi Chen, Qian Cai, Faya Liang, Debin Xu, Ping Han, Jichun Yu, Xiaoming Huang
OBJECTIVES: The aim of the present study was to analyze the association between pretreatment body mass index (BMI) and the aggressiveness of papillary thyroid carcinoma (PTC) along with its clinical outcomes in a Chinese population with BMI classification for Asians. METHODS: A retrospective, observational study was conducted on patients from two teaching hospitals in China. 1622 classical PTC patients were categorized into four groups according to BMI. RESULTS: We found that increased BMI was associated with extrathyroidal extension, multifocality, the presence of lymph node (LN) metastasis, and advancing TNM stage in PTC patients...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29081800/relationship-between-subclinical-thyroid-dysfunction-and-the-risk-of-cardiovascular-outcomes-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#13
REVIEW
Jing Sun, Liang Yao, Yuan Fang, Ruifei Yang, Yaolong Chen, Kehu Yang, Limin Tian
BACKGROUND: Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting. METHODS AND RESULTS: PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016. A total of 16 studies were included for meta-analysis. We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29081799/swim-training-attenuates-inflammation-and-improves-insulin-sensitivity-in-mice-fed-with-a-high-fat-diet
#14
Guangzeng Zhang, Pengfei Yu, Xiaomeng Liu
Exercise could afford multiple beneficial effects on obesity-related metabolic disorders. To address this issue, C57BL/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD + swim group than in the HFD + sedentary group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29081798/chronic-hyperglycemia-modulates-rat-osteoporotic-cortical-bone-microarchitecture-into-less-fragile-structures
#15
Cristina de Mello-Sampayo, Alaíde Alves Agripino, Duarte Stilwell, Bruno Vidal, Ana Luisa Fernando, Beatriz Silva-Lima, Maria Fátima Vaz, Helena Canhão, M Cristina Marques
There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women. One pointed cause might be uncontrolled glycemia. In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy). Animals (n = 28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29081797/the-clinical-values-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-levels-in-blood-and-thyroid-nodules
#16
Ayfer Altas, Fatih Kuzu, Dilek Arpaci, Mustafa Unal, Murat Can, Figen Barut, Furuzan Kokturk, Sevil Uygun Ilikhan, Taner Bayraktaroglu
AIM: Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. MATERIALS AND METHODS: In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29075293/bacterial-profile-and-antibiotic-resistance-in-patients-with-diabetic-foot-ulcer-in-guangzhou-southern-china-focus-on-the-differences-among-different-wagner-s-grades-idsa-iwgdf-grades-and-ulcer-types
#17
Xiaoying Xie, Yunwen Bao, Lijia Ni, Dan Liu, Shaona Niu, Haixiong Lin, Hongyu Li, Chaohui Duan, Li Yan, Songyin Huang, Zhaofan Luo
OBJECTIVE: To understand the bacterial profile and antibiotic resistance patterns in diabetic foot infection (DFI) in different Wagner's grades, IDSA/IWGDF grades, and different ulcer types in Guangzhou, in order to provide more detailed suggestion to the clinician about the empirical antibiotic choice. METHODS: 207 bacteria were collected from 117 DFIs in Sun Yat-sen Memorial Hospital from Jan.1, 2010, to Dec.31, 2015. The clinical data and microbial information were analyzed...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29075292/does-hba1c-level-have-clinical-implications-in-diabetic-patients-undergoing-coronary-artery-bypass-grafting-a-systematic-review-and-meta-analysis
#18
REVIEW
Jia Zheng, Jing Cheng, Tong Wang, Qian Zhang, Xinhua Xiao
AIMS/INTRODUCTION: The aim of the present study was to investigate whether HbA1c was related to clinical outcomes in diabetic patients undergoing CABG surgery. MATERIALS AND METHODS: A literature search was carried out satisfying the predefined inclusion criteria from Pubmed, Embase, and Cochrane Library. Differences were expressed as odds ratios (ORs) with 95% confidence intervals (CIs) to assess the relationships of preoperative HbA1c levels and clinical prognosis in diabetic patients...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29056965/salt-aldosterone-and-parathyroid-hormone-what-is-the-relevance-for-organ-damage
#19
REVIEW
Cristiana Catena, Gian Luca Colussi, Gabriele Brosolo, Nicole Bertin, Marileda Novello, Andrea Palomba, Leonardo A Sechi
Structured interventions on lifestyle have been suggested as a cost-effective strategy for prevention of cardiovascular disease. Epidemiologic studies demonstrate that dietary salt restriction effectively decreases blood pressure, but its influence on cardiovascular morbidity and mortality is still under debate. Evidence gathered from studies conducted in patients with primary aldosteronism, essential hypertension, or heart failure demonstrates that long-term exposure to elevated aldosterone results in cardiac structural and functional changes that are independent of blood pressure...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28951739/the-association-of-thyrotropin-and-autoimmune-thyroid-disease-in-developing-papillary-thyroid-cancer
#20
I-Shuan Lee, An-Tsz Hsieh, Ting-Wei Lee, Ting-I Lee, Yu-Mei Chien
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most common type of malignant thyroid neoplasm. However, the incidence of PTC with autoimmune thyroid disease (AITD) varies between studies. This study aims to investigate whether patients with AITD have increased incidence of PTC. We also analyzed the relationship of serum thyroid-stimulating hormone (TSH) levels and PTC in relation to AITD based on histopathological data. METHODS: A total of 533 participants who underwent thyroidectomy were enrolled in this retrospective study based on clinicohistopathological data and known thyroid autoantibodies...
2017: International Journal of Endocrinology
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