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International Journal of Endocrinology

Ting Chen, Haiying Wu, Chenxi Zhang, Jiarong Feng, Linqi Chen, Rongrong Xie, Fengyun Wang, Xiuli Chen, Huiting Zhou, Hui Sun, Fei Xiao
Background: Bone mineral density quantitative trait locus 18 (BMND18, OMIM #300910) is a type of early-onset osteogenesis imperfecta (OI) caused by loss-of-function mutations in the PLS3 gene, which encodes plastin-3, a key protein in the formation of actin bundles throughout the cytoskeleton. Here, we report a patient with PLS3 mutation caused BMND18 and evaluated all the reported disease-causing mutations by bioinformatic analysis. Methods: Targeted gene sequencing was performed to find the disease-causing mutation in our patient...
2018: International Journal of Endocrinology
Mohammad M Khan
Accumulating data from various clinical trial studies suggests that adjuvant therapy with ovarian hormones (estrogens) could be effective in reducing cognitive deficit and psychopathological symptoms in women with psychiatric disorders. However, estrogen therapy poses serious limitations and health issues including feminization in men and increased risks of thromboembolism, hot flashes, breast hyperplasia, and endometrium hyperplasia when used for longer duration in older women (aged ≥ 60 years) or in women who have genetic predispositions...
2018: International Journal of Endocrinology
Ilonka Kreitschmann-Andermahr, Sonja Siegel, Christa Gammel, Karen Campbell, Leslie Edwin, Agnieszka Grzywotz, Victoria Kuhna, Maria Koltowska-Häggström, Oliver Müller, Michael Buchfelder, Bernadette Kleist
Background: Cushing's disease (CD) and Cushing's syndrome (CS) are chronic illnesses, characterized by symptoms of prolonged hypercortisolism, which often changes to hypocortisolism after successful treatment. In view of the high disease burden of CD/CS patients and long-term impaired quality of life, the present survey was conducted to gain information about subjective illness distress and patients' specific needs in terms of supportive measures beyond medical interventions. Patients and Methods: Cross-sectional questionnaire study including patients with CD treated in 2 German neurosurgical tertiary referral centers and CD/CS patient members of a US-based patient support group completed a survey inquiring about disease burden, coping strategies, and support needs...
2018: International Journal of Endocrinology
Ilse Yessabel Martinez Munoz, Eneida Del Socorro Camarillo Romero, Jose de Jesus Garduno Garcia
The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis...
2018: International Journal of Endocrinology
Maria Giulia Santaguida, Ilenia Gatto, Giorgio Mangino, Camilla Virili, Ilaria Stramazzo, Poupak Fallahi, Alessandro Antonelli, Patrizia Gargiulo, Giovanna Romeo, Marco Centanni
Hashimoto's thyroiditis (HT) may occur associated with celiac disease (CD). Regulatory B cells (Breg) subsets have been shown to play a significant role in autoimmune processes. Therefore, we have characterized their distribution in the peripheral blood obtained from 10 patients with isolated HT, 10 patients with HT + CD, 9 patients with isolated CD, and 9 healthy donors (HD). Th17 cells were significantly increased in patients with HT and in patients bearing both HT and CD, while patients with isolated CD exhibited a lower percentage of Th17, as compared with healthy donors...
2018: International Journal of Endocrinology
Jing Hang, Fan Li, Xiao-Hui Qiao, Xin-Hua Ye, Ao Li, Lian-Fang Du
Objectives: The present study is aimed at evaluating the diagnostic value of combining shear wave elastography (SWE) parameters and the thyroid imaging reporting and data system (TIRADS) for differentiating between benign and malignant thyroid nodules. Methods: Patients who underwent conventional ultrasonography (US) and SWE before surgery were enrolled in the current study. Each nodule was given a TIRADS risk score. The effectiveness of the SWE parameters was assessed by odds ratios (ORs)...
2018: International Journal of Endocrinology
Javier Menéndez-Menéndez, Carlos Martínez-Campa
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials and multiple experimental studies performed both in vivo and in vitro have documented that the pineal hormone inhibits endocrine-dependent mammary tumors by interfering with the estrogen signaling-mediated transcription, therefore behaving as a selective estrogen receptor modulator (SERM)...
2018: International Journal of Endocrinology
Xiaofang Yu, Saifei Zhang, Long Zhang
Euglycemic diabetic ketoacidosis (EDKA) was considered a rare condition with its specific definition and precipitating factors. However, with the wide use of sodium glucose cotransporter 2 (SGLT-2) inhibitors, the newest class of antidiabetic agents, EDKA has come back into the spotlight. Relevant cases are increasingly being reported along with insights into the mechanism of EDKA. It seems increasingly clear that EDKA is more common than we used to believe. The SGLT-2 inhibitor-associated EDKA also indicates a necessary review of our previous understanding of "diabetic" ketoacidosis, since the SGLT-2 inhibitor predisposes patients to DKA in a "starvation" way...
2018: International Journal of Endocrinology
Lingqiong Meng, Shuying Liu, Aseel Al-Dayyeni, Zhifeng Sheng, Zhiguang Zhou, Xiangbing Wang
Purpose: To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods: In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD)...
2018: International Journal of Endocrinology
Joëlle Dupont, Michael J Bertoldo, Agnieszka Rak
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
L P Muñoz-de-la-Torre, J R Eguibar, C Cortés, A Ugarte, A Trujillo
Infertility and reproductive problems have been reported in women with several neurological disorders, for example, demyelination. However, the physiology of such problems has remained unknown so far. The taiep rats are an animal neurological model that initially shows a hypomyelination followed by a progressive demyelination of the central nervous system. This animal has reproductive problems, and the aim of this work is to characterize the follicular development, secretion of ovarian hormones, and presence of noradrenaline in the ovaries of the female taiep rats in the juvenile and adult stages...
2018: International Journal of Endocrinology
Katsuya Sakimura, Tatsuya Maekawa, Shin-Ichi Kume, Takeshi Ohta
In patients with diabetes mellitus (DM), impairments of circadian rhythms, including the sleep-wake cycle, blood pressure, and plasma melatonin concentrations, are frequently observed. Animal models of DM are also reported to show aberrant circadian rhythms. However, the changes in the circadian rhythms of plasma soluble substances, including melatonin, in diabetic animals are controversial. In the present study, we investigated the circadian rhythms of spontaneous locomotor activity, metabolic parameters (plasma glucose, triglyceride, and total cholesterol), and plasma melatonin concentrations in Spontaneously Diabetic Torii (SDT) fatty rats, a novel animal model of type 2 DM...
2018: International Journal of Endocrinology
Yu-Pu Hong, Wen-Yi Guo, Wei-Xing Wang, Liang Zhao, Ming-Wei Xiang, Fang-Chao Mei, Ablikim Abliz, Peng Hu, Wen-Hong Deng, Jia Yu
[This corrects the article DOI: 10.1155/2016/4592346.].
2018: International Journal of Endocrinology
Jia Zhang, Wenhua Zhu, Lifeng Qiu, Lijuan Huang, Lizheng Fang
Objectives: To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods: A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), and conicity index (CI) were measured. Receiver-operating characteristic curves analyses were performed to determine the discriminatory power of these indices for the identification of cardiometabolic risks and diagnosis of MetS...
2018: International Journal of Endocrinology
Shi-Ying Zhang, Kai-Lin Yang, Liu-Ting Zeng, Xiao-He Wu, Hui-Yong Huang
Objective: To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods: Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result: Thirteen trials involving 765 patients were included...
2018: International Journal of Endocrinology
Agnieszka Nikołajuk, Natalia Matulewicz, Magdalena Stefanowicz, Monika Karczewska-Kupczewska
Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proinflammatory proatherogenic factors and biomarkers of endothelial activation was observed in diabetes and CVD. The aim of our study was to assess serum proatherogenic and proinflammatory factors in young healthy nonobese subjects with positive family history of type 2 diabetes...
2018: International Journal of Endocrinology
L Antonio, S Pauwels, M R Laurent, D Vanschoubroeck, I Jans, J Billen, F Claessens, B Decallonne, Diane De Neubourg, P Vermeersch, D Vanderschueren
Background: Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone-binding globulin (SHBG) and albumin. Only 1-2% of nonprotein-bound testosterone (so-called free testosterone) is biologically active and responsible for androgen action. Moreover, automated immunoassays which are frequently used for female testosterone measurements are inaccurate...
2018: International Journal of Endocrinology
Ali Cenk Ozay, Ozlen Emekci Ozay, Recep Emre Okyay, Erkan Cagliyan, Tuncay Kume, Bulent Gulekli
[This corrects the article DOI: 10.1155/2016/3206872.].
2018: International Journal of Endocrinology
Yan Sun, Wenxiang Wang, Qi Shen, Shengrong Du, Yiwei Guo, Fei He, Wenchang Zhang
Although quite a few polycystic ovary syndrome (PCOS) patients suffering from metabolic syndrome (MS) have been reported in previous studies, no reliable and early diagnostic biomarkers for MS in PCOS patients have yet been identified. To identify early and reliable diagnostic biomarkers for MS in Chinese women with PCOS, a total of 401 patients (200 PCOS patients and 201 controls) were enrolled in our present study. All of the subjects were examined for anthropometric (weight, waist circumference, blood pressure, etc...
2018: International Journal of Endocrinology
Pietro Cavalli, Elena Ronda
[This corrects the article DOI: 10.1155/2017/5846286.].
2018: International Journal of Endocrinology
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