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International Journal of Endocrinology

Kun Wang, Qun-Fang Yang, Xing-Lin Chen, Yu-Wei Liu, Sheng-Shuai Shan, Hua-Bo Zheng, Xiao-Fang Zhao, Chang-Zhong Chen, Cheng-Yun Liu
Introduction: It has well established that metabolic syndrome (MetS) can predict the risk of type 2 diabetes mellitus (T2DM) in some population groups. However, limited evidence is available regarding the predictive effect of MetS for incident T2DM in mainland Chinese population. Methods: A 3-year cohort study was performed for 9735 Chinese without diabetes at baseline. MetS and its components were assessed by multivariable analysis using Cox regression. Prediction models were developed...
2018: International Journal of Endocrinology
Lei Kong, Dongxu Wang, Shanshan Li, Chengsheng Zhang, Xiuyun Jiang, Qingbo Guan, Zhenlin Zhang, Fei Jing, Jin Xu
Objective: Spondyloepiphyseal dysplasia tarda (SEDT) is a rare hereditary bone disease characterized by spinal and epiphyseal anomalies. We identified the disease by gene sequencing in a Chinese pedigree with SEDT. Methods: We extracted genomic DNA from five members of a four-generation Chinese SEDT kindred with three affected males and then analyzed the genetic mutation by PCR and DNA sequencing. Results: DNA sequencing showed that the genetic missense mutation occurred one bp upstream of exon 6 in the SEDL gene in two families, and a heterozygous mutation was found in a female carrier...
2018: International Journal of Endocrinology
Michishige Terasaki, Munenori Hiromura, Yusaku Mori, Kyoko Kohashi, Hideki Kushima, Masakazu Koshibu, Tomomi Saito, Hironori Yashima, Takuya Watanabe, Tsutomu Hirano
Dipeptidyl peptidase-4 (DPP-4) inhibitors could have antiatherosclerotic action, in addition to antihyperglycemic roles. Because macrophage foam cells are key components of atherosclerosis, we investigated the effect of the DPP-4 inhibitor teneligliptin on foam cell formation and its related gene expression levels in macrophages extracted from diabetic db/db ( C57BLKS/J Iar -+Leprdb /+Leprdb ) mice and type 2 diabetes (T2D) patients ex vivo. We incubated mouse peritoneal macrophages and human monocyte-derived macrophages differentiated by 7-day culture with oxidized low-density lipoprotein in the presence/absence of teneligliptin (10 nmol/L) for 18 hours...
2018: International Journal of Endocrinology
Huilin Tang, Deming Li, Yufeng Li, Xi Zhang, Yiqing Song, Xinli Li
Aims: Emerging evidence has suggested a mechanistic link from vitamin D metabolism to glucose and insulin homeostasis. This study is aimed at specifically quantifying the direct effects of vitamin D supplementation on indexes of glucose and insulin homeostasis as well as incidence of type 2 diabetes (T2D) among nondiabetic adults. Methods: We systematically searched randomized controlled trials (RCTs) of vitamin D supplementation in nondiabetic adults in PubMed, EMBASE, and CENTRAL...
2018: International Journal of Endocrinology
J Fandiño, A A Vaz, L Toba, M Romaní-Pérez, L González-Matías, F Mallo, Y Diz-Chaves
In utero growth restriction and being born small for gestational age are risk factors for respiratory morbidity. IUGR (in utero growth retardation) is associated to overall reduction in lung weight, surfactant content and activity, impaired maturation of the alveolar type II cells, and decreased alveolar formation. The renin-angiotensin system (RAS) may be a key target underlying pathophysiological lung alterations. GLP-1 and agonists of its receptor modulate the expression levels of different components of RAS and also are very important for lung maturation and the production of surfactant proteins...
2018: International Journal of Endocrinology
Jakub Warakomski, Ewa Romuk, Barbara Jarząb, Jolanta Krajewska, Lucyna Siemińska
The relationships between thyroid cancer and obesity are not fully understood. Adipokines, proinflammatory cytokines, and vitamin D may mediate these associations. In this study, we estimated serum concentrations of leptin, adiponectin, chemerin, interleukin-6 (IL-6), and vitamin D in patients with papillary thyroid cancer (PTC). We searched for associations between the adipokines, IL-6, vitamin D, anthropometric parameters, and TNM AJCC/UICC 2017 classification in 177 patients diagnosed with PTC (151 women and 26 men)...
2018: International Journal of Endocrinology
Zhen Li, Qi Huang, Li Sun, Tengfei Bao, Zhe Dai
Objective: This study was designed to investigate risk factors related to atherogenic index of plasma (AIP), as well as the relationship between AIP and chronic microvascular complications in patients with type 2 diabetes (T2DM). Methods: This study included 2523 patients with T2DM who had not been treated with lipid-lowering drugs and were admitted to the Department of Endocrinology at Zhongnan Hospital, Wuhan University, during the period from January 2015 to February 2018...
2018: International Journal of Endocrinology
Felix Behling, Jürgen Honegger, Marco Skardelly, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm
The development of somatostatin analogs for the treatment of pituitary Cushing's disease has been based on somatostatin receptor expression analyses of small cohorts of pituitary adenomas. Additionally, the classification of pituitary adenomas has recently changed. To enable progress with this treatment option, we assessed somatostatin receptors in a large cohort of corticotroph and other pituitary adenomas according to the new WHO classification of endocrine tumors. Paraffin-embedded tumor samples of 88 corticotroph pituitary adenomas and 30 nonadenomatous pituitary biopsies were analyzed after processing into tissue microarrays and immunohistochemical staining for SSTR 1, SSTR2A, SSTR3, SSTR4, and SSTR5...
2018: International Journal of Endocrinology
Yan Zhang, Ming-Bo Zhang, Yu-Kun Luo, Jie Li, Zhi-Li Wang, Jie Tang
Background: Contrast-enhanced ultrasound (CEUS) scanning can detect differences between thyroid tumors and surrounding tissues. However, enhancement patterns within nodules are insufficient for the diagnosis of thyroid carcinomas. The peripheral enhancement patterns of nodules may provide useful diagnostic information. The objective of this study was to investigate the diagnostic accuracy of the peripheral enhancement patterns during CEUS scanning of thyroid nodules. Material and Methods: 120 nodules with peripheral rings during CEUS and definite pathology confirmed by surgery were included in this study...
2018: International Journal of Endocrinology
Goran Kuvačić, Luca Paolo Ardigò, Johnny Padulo
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
Rafael Martins de Morais, Alaor Barra Sobrinho, Calliandra Maria de Souza Silva, Jamila Reis de Oliveira, Izabel Cristina Rodrigues da Silva, Otávio de Toledo Nóbrega
Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper's objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer...
2018: International Journal of Endocrinology
Feiyu Jiang, Min Yang, Xili Zhao, Rui Liu, Gangyi Yang, Dongfang Liu, Hua Liu, Hongting Zheng, Zhiming Zhu, Ling Li
Objective: C1q/TNF-related protein5 (CTRP5) is a member of the C1q/tumor necrosis factor α - (TNF- α -) related protein family and has been reported to be associated with the regulation of glucose and lipid metabolism. However, the clinical association between CTRP5 and metabolic syndrome (MetS) has not been reported. The aim of the current study is to investigate the association between CTRP5 and MetS by a cross-sectional study. Methods: We performed a cross-sectional study in a Chinese population including 89 controls and 88 MetS individuals...
2018: International Journal of Endocrinology
Arturo Bevilacqua, Mariano Bizzarri
In the past decades, both the importance of inositol for human health and the complex interaction between glucose and inositol have been the subject of increasing consideration. Glucose has been shown to interfere with cellular transmembrane transport of inositol, inhibiting, among others, its intestinal absorption. Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol...
2018: International Journal of Endocrinology
Naru Babaya, Hironori Ueda, Shinsuke Noso, Yoshihisa Hiromine, Michiko Itoi-Babaya, Misato Kobayashi, Tomomi Fujisawa, Hiroshi Ikegami
Introduction: Streptozotocin- (STZ-) induced diabetes is under polygenic control, and the genetic loci for STZ susceptibility are mapped to chromosome (Chr) 11 in Nagoya-Shibata-Yasuda (NSY) mice. In addition to Chr11, other genes on different chromosomes may contribute to STZ susceptibility in NSY mice. The aim of this study was to determine whether NSY-Chr14 contributes to STZ susceptibility and contains the STZ-susceptible region. Materials and Methods: A consomic C3H-14NSY strain (R0: homozygous for NSY-derived whole Chr14 on the control C3H background), two congenic strains (R1: the region retained proximal and middle segments of NSY-Chr14 and R2: the region retained a proximal segment of NSY-Chr14), and parental NSY and C3H mice were intraperitoneally injected with a single injection of STZ at a dose of 175 mg/kg body weight at 12 weeks of age...
2018: International Journal of Endocrinology
Antonio Simone Laganà, Salvatore Giovanni Vitale, Marco Noventa, Amerigo Vitagliano
No abstract text is available yet for this article.
2018: International Journal of Endocrinology
Ying Zhang, Yang Wang, Xiao Jun Tao, Qian Li, Feng Fei Li, Kok Onn Lee, Dong Mei Li, Jian Hua Ma
Purpose: To determine if the TSH is related to estimated glomerular filtration rate (eGFR) in T2D patients without overt thyroid dysfunction. Methods: A cohort study of 5936 T2D patients was assessed for thyroid and kidney functions, in whom 248 with subclinical hyperthyroidism and 362 with subclinical hypothyroidism. Serum creatinine and 24-hour urine albumin excretion (UAE) were collected. Chronic kidney disease (CKD) was defined as eGFR < 60 ml/min/1...
2018: International Journal of Endocrinology
Danilo Bianchini Höfling, Maria Cristina Chavantes, Carlos Alberto Buchpiguel, Giovanni Guido Cerri, Suemi Marui, Paulo Campos Carneiro, Maria Cristina Chammas
Introduction: A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT). Objective: The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT. Materials and Methods: Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Twenty-five were subjected to LLLT (group L), and 18 were subjected to placebo (group P)...
2018: International Journal of Endocrinology
Qin-Fen Chen, Dan Cao, Ting-Ting Ye, Hui-Hui Deng, Hong Zhu
Background: The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods: We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly...
2018: International Journal of Endocrinology
Maiara Destro Inácio, Alex Rafacho, Nathália Aparecida de Paula Camaforte, Poliana Teixeira, Priscilla Maria Ponce Vareda, Natália Moretti Violato, José Roberto Bosqueiro
Objective: Fibrates are used as lipid-lowering drugs and are well tolerated as cotreatments when glucose metabolism disturbances are also present. Synthetic glucocorticoids (GCs) are diabetogenic drugs that cause dyslipidemia, dysglycemia, glucose intolerance, and insulin resistance when in excess. Thus, we aimed to describe the potential of bezafibrate in preventing or attenuating the adverse effects of GCs on glucose and lipid homeostasis. Methods: Male Wistar rats were treated with high-dose bezafibrate (300 mg/kg, body mass (b...
2018: International Journal of Endocrinology
Sandeep Dhindsa, Rama Chemitiganti, Husam Ghanim, Evangelina Santiago, Adnan Haider, Natalia Chaar, Mary Mok, Alexis McKee, Paresh Dandona
A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men)...
2018: International Journal of Endocrinology
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