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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/28293260/treatment-with-myo-inositol-and-selenium-ensures-euthyroidism-in-patients-with-autoimmune-thyroiditis
#1
Maurizio Nordio, Sabrina Basciani
Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto's thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6 mIU/L, elevated serum antithyroid peroxidase (TPOAb) and/or antithyroglobulin (TgAb), and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels were enrolled in the study: one hyperthyroid subject with TSH about 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28293259/influence-of-normo-and-hypogonadal-condition-hyperuricemia-and-high-fructose-diet-on-renal-changes-in-male-rats
#2
Jimena Soutelo, Yanina Alejandra Samaniego, Elsa Zotta, María Cecilia Fornari, Carlos Reyes Toso, Osvaldo Juan Ponzo
Background. There is a gender disparity in the incidence, prevalence, and progression of renal disease. The object of this paper is to evaluate the presence and type of renal lesion in normogonadic and hypogonadic male rats in a mild hyperuricemia induced condition and exposed to a high-fructose diet. Methods. 56 adult male Wistar rats were used. Animals were divided into two groups, one normogonadic (NGN) and one hypogonadic (HGN), and each group was divided into four subgroups in accordance with the treatment: control with only water (C), fructose (F), oxonic acid (OA), and fructose + oxonic acid (FOA)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28280507/fine-needle-aspiration-of-thyroid-nodules-using-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience-in-a-rural-setting
#3
Aili Guo, Yuuki Kaminoh, Terra Forward, Frank L Schwartz, Scott Jenkinson
Background. Fine needle aspiration (FNA) remains the first-line diagnostic in management of thyroid nodules and reduces unnecessary surgeries. However, it is still challenging since cytological results are not always straightforward. This study aimed to examine the results of thyroid FNA using the Bethesda system for reporting thyroid cytopathology (TBSRTC) to establish the level of accuracy of FNA procedures in a rural practice setting. Method. A retrospective chart review was conducted on existing thyroid FNA performed in a referral endocrine center between December 2011 and November 2015...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28255300/serum-osteoprotegerin-is-a-potential-biomarker-of-insulin-resistance-in-chinese-postmenopausal-women-with-prediabetes-and-type-2-diabetes
#4
Peng Duan, Min Yang, Meilin Wei, Jia Liu, Ping Tu
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n = 93), impaired glucose regulation (IGR) (n = 90), and normal glucose regulation group (NGR) (n = 88), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#5
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28250769/pediatric-tsh-reference-intervals-and-prevalence-of-high-thyroid-antibodies-in-the-lebanese-population
#6
Marie-Hélène Gannagé-Yared, Nicole Balech, Vanessa Farah, Marianne Antar, Rindala Saliba, Elise Chahine
The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8-18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is 2.06 ± 1...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28250768/the-effect-of-sitagliptin-on-the-regression-of-carotid-intima-media-thickening-in-patients-with-type-2-diabetes-mellitus-a-post-hoc-analysis-of-the-sitagliptin-preventive-study-of-intima-media-thickness-evaluation
#7
Tomoya Mita, Naoto Katakami, Toshihiko Shiraiwa, Hidenori Yoshii, Masahiko Gosho, Iichiro Shimomura, Hirotaka Watada
Background. The effect of dipeptidyl peptidase-4 (DPP-4) inhibitors on the regression of carotid IMT remains largely unknown. The present study aimed to clarify whether sitagliptin, DPP-4 inhibitor, could regress carotid intima-media thickness (IMT) in insulin-treated patients with type 2 diabetes mellitus (T2DM). Methods. This is an exploratory analysis of a randomized trial in which we investigated the effect of sitagliptin on the progression of carotid IMT in insulin-treated patients with T2DM. Here, we compared the efficacy of sitagliptin treatment on the number of patients who showed regression of carotid IMT of ≥0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28243254/myoinositol-the-bridge-ponti-to-reach-a-healthy-pregnancy
#8
REVIEW
Pietro Cavalli, Elena Ronda
The use of folic acid in the periconceptional period can prevent about 70% of neural tube defects (NTDs). In the remaining cases, no medical prevention is available, and those conditions should be defined as folate-resistant NTDs. Rodent models suggest that some folate-resistant NTDs can be prevented by inositol (myoinositol and chiroinositol) supplementation prior to pregnancy. Should folic acid be combined with myoinositol periconceptional supplementation to reduce the overall risk of NTDs even in humans? Hereafter, we discuss the results from the PONTI study that strongly support both the effectiveness and safety of myoinositol periconceptional supplementation in preventing human NTDs...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28167962/corrigendum-to-pancreatic-function-type-2-diabetes-and-metabolism-in-aging
#9
Zhenwei Gong, Radhika H Muzumdar
[This corrects the article DOI: 10.1155/2012/320482.].
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28243253/influence-of-androgen-receptor-gene-cag-and-ggc-polymorphisms-on-male-sexual-function-a-cross-sectional-study
#10
Giacomo Tirabassi, Giovanni Corona, Sara Falzetti, Nicola Delli Muti, Mario Maggi, Giancarlo Balercia
Background. No study has assessed the possible involvement of GGC androgen receptor (AR) polymorphism in sexual function. Our aim is to evaluate the association between CAG and GGC AR polymorphisms in this function. Methods. We retrospectively examined eighty-five outpatients. Clinical, biochemical, and genetic parameters were considered. Sexual assessment was performed using the International Index of Erectile Function (IIEF) which evaluates erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), and overall satisfaction (OS)...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28074095/multidisciplinary-management-of-pituitary-apoplexy
#11
REVIEW
Adriana Albani, Francesco Ferraù, Filippo Flavio Angileri, Felice Esposito, Francesca Granata, Felicia Ferreri, Salvatore Cannavò
Pituitary apoplexy is a rare clinical syndrome due to ischemic or haemorrhagic necrosis of the pituitary gland which complicates 2-12% of pituitary tumours, especially nonfunctioning adenomas. In many cases, it results in severe neurological, ophthalmological, and endocrinological consequences and may require prompt surgical decompression. Pituitary apoplexy represents a rare medical emergency that necessitates a multidisciplinary approach. Modalities of treatment and times of intervention are still largely debated...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28074094/to-identify-predictors-of-central-lymph-node-metastasis-in-patients-with-clinically-node-negative-conventional-papillary-thyroid-carcinoma
#12
Jiru Yuan, Gang Zhao, Jialin Du, Xiaoyi Chen, Xiaodong Lin, Zhengbo Chen, Zeyu Wu
Objective. The aim of this study was to identify the risk factors associated with central lymph node metastasis (CLNM) in patients with clinically node-negative conventional papillary thyroid carcinoma (cN0 CPTC). Methods. A total of 190 cN0 CPTC patients who underwent thyroidectomy with prophylactic central neck dissection (pCND) in the Department of General Surgery at Guangdong General Hospital between March 2014 and December 2015 were assessed retrospectively. The relations of CLNM with clinicopathologic characteristics of cN0 CPTC were analyzed by univariate and multivariate logistic regression...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28050167/maternal-diet-supplementation-with-n-6-n-3-essential-fatty-acids-in-a-1-2%C3%A2-%C3%A2-1-0-ratio-attenuates-metabolic-dysfunction-in-msg-induced-obese-mice
#13
Josiane Morais Martin, Rosiane Aparecida Miranda, Luiz Felipe Barella, Kesia Palma-Rigo, Vander Silva Alves, Gabriel Sergio Fabricio, Audrei Pavanello, Claudinéia Conationi da Silva Franco, Tatiane Aparecida Ribeiro, Jesuí Vergílio Visentainer, Elton Guntendeorfer Banafé, Clayton Antunes Martin, Paulo Cezar de Freitas Mathias, Júlio Cezar de Oliveira
Essential polyunsaturated fatty acids (PUFAs) prevent cardiometabolic diseases. We aimed to study whether a diet supplemented with a mixture of n-6/n-3 PUFAs, during perinatal life, attenuates outcomes of long-term metabolic dysfunction in prediabetic and obese mice. Seventy-day-old virgin female mice were mated. From the conception day, dams were fed a diet supplemented with sunflower oil and flaxseed powder (containing an n-6/n-3 PUFAs ratio of 1.2 : 1.0) throughout pregnancy and lactation, while control dams received a commercial diet...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28044078/erratum-to-inositols-in-the-treatment-of-insulin-mediated-diseases
#14
Giovanna Muscogiuri, Stefano Palomba, Antonio Simone Laganà, Francesco Orio
[This corrects the article DOI: 10.1155/2016/3058393.].
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28044077/fracture-risk-in-type-2-diabetes-current-perspectives-and-gender-differences
#15
REVIEW
Giuseppina T Russo, Annalisa Giandalia, Elisabetta L Romeo, Morabito Nunziata, Marco Muscianisi, Maria Concetta Ruffo, Antonino Catalano, Domenico Cucinotta
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fractures, resulting in disabilities and increased mortality. The pathophysiological mechanisms linking diabetes to osteoporosis have not been fully explained, but alterations in bone structure and quality are well described in diabetic subjects, likely due to a combination of different factors. Insulin deficiency and dysfunction, obesity and hyperinsulinemia, altered level of oestrogen, leptin, and adiponectin as well as diabetes-related complications, especially peripheral neuropathy, orthostatic hypotension, or reduced vision due to retinopathy may all be associated with an impairment in bone metabolism and with the increased risk of fractures...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28042294/gender-differences-in-risks-of-coronary-heart-disease-and-stroke-in-patients-with-type-2-diabetes-mellitus-and-their-association-with-metabolic-syndrome-in-china
#16
Mei-Fang Yao, Jie He, Xue Sun, Xiao-Li Ji, Yue Ding, Yi-Ming Zhao, Han-Yu Lou, Xiao-Xiao Song, Li-Zhen Shan, Ying-Xiu Kang, Song-Zhao Zhang, Peng-Fei Shan
Coronary heart disease (CHD) and stroke are common complications of type 2 diabetes mellitus (T2DM). We aimed to explore the differences in the risks of CHD and stroke between Chinese women and men with T2DM and their association with metabolic syndrome (MS). This study included 1514 patients with T2DM. The Asian Guidelines of ATPIII (2005) were used for MS diagnosis, and the UKPDS risk engine was used to evaluate the 10-year CHD and stroke risks. Women had lower CHD risk (15.3% versus 26.3%), fatal CHD risk (11...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28018430/gc-gene-polymorphisms-and-vitamin-d-binding-protein-levels-are-related-to-the-risk-of-generalized-aggressive-periodontitis
#17
Wenli Song, Xian'e Wang, Yu Tian, Xin Zhang, Ruifang Lu, Huanxin Meng
Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28018429/408-cases-of-genital-ambiguity-followed-by-single-multidisciplinary-team-during-23-years-etiologic-diagnosis-and-sex-of-rearing
#18
Georgette Beatriz De Paula, Beatriz Amstalden Barros, Stela Carpini, Bruna Jordan Tincani, Tais Nitsch Mazzola, Mara Sanches Guaragna, Cristiane Santos da Cruz Piveta, Laurione Candido de Oliveira, Juliana Gabriel Ribeiro Andrade, Guilherme Guaragna-Filho, Pedro Perez Barbieri, Nathalia Montibeler Ferreira, Marcio Lopes Miranda, Ezequiel Moreira Gonçalves, Andre Moreno Morcillo, Nilma Lucia Viguetti-Campos, Sofia Helena Valente Lemos-Marini, Roberto Benedito de Paiva Silva, Antonia Paula Marques-de-Faria, Maricilda Palandi De Mello, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior
Objective. To evaluate diagnosis, age of referral, karyotype, and sex of rearing of cases with disorders of sex development (DSD) with ambiguous genitalia. Methods. Retrospective study during 23 years at outpatient clinic of a referral center. Results. There were 408 cases; 250 (61.3%) were 46,XY and 124 (30.4%) 46,XX and 34 (8.3%) had sex chromosomes abnormalities. 189 (46.3%) had 46,XY testicular DSD, 105 (25.7%) 46,XX ovarian DSD, 95 (23.3%) disorders of gonadal development (DGD), and 19 (4.7%) complex malformations...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28003823/larger-thyroid-volume-and-adequate-iodine-nutrition-in-chinese-schoolchildren-local-normative-reference-values-compared-with-who-ign
#19
Zhe Mo, Xiaoming Lou, Guangming Mao, Zhifang Wang, Wenming Zhu, Zhijian Chen, Xiaofeng Wang
Objective. Thyroid volume measured by ultrasound to define goiter needs reliable local thyroid volume reference from iodine-sufficient populations. The aim of this study is to explore the reference interval for normal thyroid volume in schoolchildren aged 8-10 years from Zhejiang Province, China. Methods. A probability-proportionate-to-size sampling method was applied to select a representative sample of 1213 children aged 8-10 years in Zhejiang Province to detect the thyroid volume, salt iodine, and urine iodine...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27999593/long-term-clinical-outcomes-of-invasive-giant-prolactinomas-after-a-mean-ten-year-followup
#20
Ze Rui Wu, Yong Zhang, Lin Cai, Shao Jian Lin, Zhi Peng Su, Yong Xu Wei, Han Bing Shang, Wen Lei Yang, Wei Guo Zhao, Zhe Bao Wu
Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs). Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery prior to BRC treatment. Results. After a mean follow-up period of 135.5 ± 4.7 months, the clinical symptoms in all patients improved by different degrees...
2016: International Journal of Endocrinology
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