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International Journal of Endocrinology

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https://www.readbyqxmd.com/read/28421113/chronic-hyperinsulinaemic-hypoglycaemia-in-rats-is-accompanied-by-increased-body-weight-hyperleptinaemia-and-decreased-neuronal-glucose-transporter-levels-in-the-brain
#1
Vivi F H Jensen, Anne-Marie Mølck, Melissa Chapman, Lene Alifrangis, Lene Andersen, Jens Lykkesfeldt, Ingrid B Bøgh
The brain is vulnerable to hypoglycaemia due to a continuous need of energy substrates to meet its high metabolic demands. Studies have shown that severe acute insulin-induced hypoglycaemia results in oxidative stress in the rat brain, when neuroglycopenia cannot be evaded despite increased levels of cerebral glucose transporters. Compensatory measures in the brain during chronic insulin-induced hypoglycaemia are less well understood. The present study investigated how the brain of nondiabetic rats copes with chronic insulin-induced hypoglycaemia for up to eight weeks...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28421112/self-monitoring-of-blood-glucose-to-assess-dawn-phenomenon-in-chinese-people-with-type-2-diabetes-mellitus
#2
Wen Wu, Yuxin Huang, Jieyuzhen Qiu, Jiao Sun, Haidong Wang
Aims. We investigated whether self-monitoring of blood glucose could be used to assess dawn phenomenon in Chinese people with type 2 diabetes mellitus (T2DM). Methods. A total of 306 people with T2DM underwent continuous glucose monitoring and self-monitoring of blood glucose for 72 h. A linear model was used to fit the optimal linear formula of the magnitude of dawn phenomenon (ΔDawn) and self-monitoring of blood glucose values. Results. The prevalence of dawn phenomenon was similar within different oral antidiabetic drug groups (42...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28421111/xrcc5-vntr-xrcc6-61c-g-and-xrcc7-6721g-t-gene-polymorphisms-associated-with-male-infertility-risk-evidences-from-case-control-and-in-silico-studies
#3
Danial Jahantigh, Abasalt Hosseinzadeh Colagar
We evaluate the association between genetic polymorphisms of XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T with male infertility susceptibility. A total of 392 men including 178 infertile males (102 idiopathic azoospermia and 76 severe oligozoospermia) and 214 healthy controls were recruited. XRCC6 -61C>G and XRCC7 6721G>T genotyping was performed by PCR-RFLP whereas XRCC5 VNTR was performed by PCR. The 2R allele and 2R allele carriers of XRCC5 VNTR polymorphism significantly decreased risk of male infertility...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28408927/activities-of-amphioxus-gh-like-protein-in-osmoregulation-insight-into-origin-of-vertebrate-gh-family
#4
Mengyang Li, Chengyan Jiang, Yu Zhang, Shicui Zhang
GH is known to play an important role in both growth promotion and osmoregulation in vertebrates. We have shown that amphioxus possesses a single GH-like hormone (GHl) gene encoding a functional protein capable of promoting growth. However, if GHl can mediate osmoregulation remains open. Here, we demonstrated clearly that GHl increased not only the survival rate of amphioxus but also the muscle moisture under high salinity. Moreover, GHl induced the expression of both the ion transporter Na(+)-K(+)-ATPase (NKA) and Na(+)-K(+)-2Cl(-) cotransporter (NKCC) in the gill as well as the mediator of GH action IGFl in the hepatic caecum, indicating that GHl fulfills this osmoregulatory activity through the same mechanisms of vertebrate GH...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28408926/male-hypogonadism-and-osteoporosis-the-effects-clinical-consequences-and-treatment-of-testosterone-deficiency-in-bone-health
#5
REVIEW
Gary Golds, Devon Houdek, Terra Arnason
It is well recognized that bone loss accelerates in hypogonadal states, with female menopause being the classic example of sex hormones affecting the regulation of bone metabolism. Underrepresented is our knowledge of the clinical and metabolic consequences of overt male hypogonadism, as well as the more subtle age-related decline in testosterone on bone quality. While menopause and estrogen deficiency are well-known risk factors for osteoporosis in women, the effects of age-related testosterone decline in men on bone health are less well known...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28408925/combination-therapy-with-a-sodium-glucose-cotransporter-2-inhibitor-and-a-dipeptidyl-peptidase-4-inhibitor-additively-suppresses-macrophage-foam-cell-formation-and-atherosclerosis-in-diabetic-mice
#6
Michishige Terasaki, Munenori Hiromura, Yusaku Mori, Kyoko Kohashi, Hideki Kushima, Makoto Ohara, Takuya Watanabe, Olov Andersson, Tsutomu Hirano
Dipeptidyl peptidase-4 inhibitors (DPP-4is), in addition to their antihyperglycemic roles, have antiatherosclerotic effects. We reported that sodium-glucose cotransporter 2 inhibitors (SGLT2is) suppress atherosclerosis in a glucose-dependent manner in diabetic mice. Here, we investigated the effects of combination therapy with SGLT2i and DPP-4i on atherosclerosis in diabetic mice. SGLT2i (ipragliflozin, 1.0 mg/kg/day) and DPP-4i (alogliptin, 8.0 mg/kg/day), either alone or in combination, were administered to db/db mice or streptozotocin-induced diabetic apolipoprotein E-null (Apoe(-/-) ) mice...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28396686/expression-of-somatostatin-receptor-2-in-somatotropinoma-correlated-with-the-short-term-efficacy-of-somatostatin-analogues
#7
Wenjuan Liu, Lina Xie, Min He, Ming Shen, Jingjing Zhu, Yeping Yang, Meng Wang, Ji Hu, Hongying Ye, Yiming Li, Yao Zhao, Zhaoyun Zhang
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acromegalic patients were included in our study. These patients were categorized into either a SSA-pretreated group (SA, n = 63) or a direct-surgery group (DS, n = 30), depending on whether or not presurgical SSA treatment was received...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28396685/associations-of-two-obesity-related-single-nucleotide-polymorphisms-with-adiponectin-in-chinese-children
#8
Lijun Wu, Liwang Gao, Xiaoyuan Zhao, Meixian Zhang, Jianxin Wu, Jie Mi
Purpose. Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (MC4R) gene and rs6265 near the brain-derived neurotrophic factor (BDNF) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism. Methods...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28396684/muscarinic-receptors-types-1-and-2-in-the-preoptic-anterior-hypothalamic-areas-regulate-ovulation-unequally-in-the-rat-oestrous-cycle
#9
Yadira L López-Ramírez, Kayro López-Ramírez, Isabel Arrieta-Cruz, Angélica Flores, Luciano Mendoza-Garcés, Raúl A Librado-Osorio, Roger Gutiérrez-Juárez, Roberto Domínguez, María Esther Cruz
Muscarinic receptors types 1 (m1AChR) and 2 (m2AChR) in the preoptic and anterior hypothalamus areas (POA-AHA) were counted, and the effects of blocking these receptors on spontaneous ovulation were analysed throughout the rat oestrous cycle. Rats in each phase of the oestrous cycle were assigned to the following experiments: (1) an immunohistochemical study of the number of cells expressing m1AChR or m2AChR in the POA-AHA and (2) analysis of the effects of the unilateral blockade of the m1AChR (pirenzepine, PZP) or m2AChR (methoctramine, MTC) on either side of the POA-AHA on the ovulation rate...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28392801/metabolic-syndrome-in-people-living-with-human-immunodeficiency-virus-an-assessment-of-the-prevalence-and-the-agreement-between-diagnostic-criteria
#10
Kim Anh Nguyen, Nasheeta Peer, Anniza de Villiers, Barbara Mukasa, Tandi E Matsha, Edward J Mills, Andre Pascal Kengne
Objectives. We determined metabolic syndrome (MetS) prevalence and assessed the agreement between different diagnostic criteria in HIV-infected South Africans. Method. A random sample included 748 HIV-infected adult patients (79% women) across 17 HIV healthcare facilities in the Western Cape Province. MetS was defined using the Joint Interim Statement (JIS 2009), International Diabetes Federation (IDF 2005), and Adult Treatment Panel III (ATPIII 2005) criteria. Results. Median values were 38 years (age), 5 years (diagnosed HIV duration), and 392 cells/mm(3) (CD4 count), and 93% of the participants were on antiretroviral therapy (ART)...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28386277/thyroid-related-protein-expression-in-the-human-thymus
#11
Mi Jeong Kim, So Won Oh, Hyewon Youn, Juri Na, Keon Wook Kang, Do Joon Park, Young Joo Park, Ja June Jang, Kyu Eun Lee, Kyeong Cheon Jung, June-Key Chung
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer. However, the normal thymic uptake of radioiodine has occasionally been observed in young patients. We evaluated the expression of thyroid-related genes and proteins in the human thymus. Thymic tissues were obtained from 22 patients with thyroid cancer patients of all ages. The expression of NIS, thyroid-stimulating hormone receptor (TSHR), thyroperoxidase (TPO), and thyroglobulin (Tg) was investigated using immunohistochemistry and quantitative RT-PCR...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28386276/cholesterol-synthesis-increased-in-the-mmi-induced-subclinical-hypothyroidism-mice-model
#12
Yongfeng Song, Xiujuan Zhang, Wenbin Chen, Ling Gao
Subclinical hypothyroidism (SCH) is defined as increased serum thyroid-stimulating hormone (TSH) concentrations and normal serum thyroid hormone (TH) levels as well as an increased serum cholesterol level, which is an important cause of secondary hypercholesterolemia and cardiovascular diseases. Some studies have demonstrated a direct effect of TSH on cholesterol metabolism via in vivo and in vitro experiments. However, because no suitable SCH model has been established until now, the changes in cholesterol synthesis that occur in SCH patients remain unknown...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28386275/endocrine-gland-derived-vascular-endothelial-growth-factor-prokineticin-1-in-cancer-development-and-tumor-angiogenesis
#13
REVIEW
Ana Silvia Corlan, Anca Maria Cîmpean, Adriana-Andreea Jitariu, Eugen Melnic, Marius Raica
A lot of data suggests endocrine gland-derived vascular endothelial growth factor (EG-VEGF) to be restricted to endocrine glands and to some endocrine-dependent organs. Many evidences show that EG-VEGF stimulates angiogenesis and cell proliferation, although it is not a member of the VEGF family. At the time, a lot of data regarding the role of this growth factor in normal development are available. However, controversial results have been published in the case of pathological conditions and particularly in malignant tumors...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28373882/increased-chromosomal-and-oxidative-dna-damage-in-patients-with-multinodular-goiter-and-their-association-with-cancer
#14
Hamiyet Donmez-Altuntas, Fahri Bayram, Nazmiye Bitgen, Sibel Ata, Zuhal Hamurcu, Gulden Baskol
Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. This study evaluates cytokinesis-block micronucleus cytome (CBMN-cyt) assay parameters and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones in patients with multinodular goiter...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28367214/the-associations-of-serum-uric-acid-with-obesity-related-acanthosis-nigricans-and-related-metabolic-indices
#15
Cuiling Zhu, Ran Cui, Mingming Gao, Sharvan Rampersad, Hui You, Chunjun Sheng, Peng Yang, Hui Sheng, Xiaoyun Cheng, Le Bu, Shen Qu
Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28356911/factors-associated-with-the-prevalence-of-thyroid-nodules-and-goiter-in-middle-aged-euthyroid-subjects
#16
Dalia Dauksiene, Janina Petkeviciene, Jurate Klumbiene, Rasa Verkauskiene, Jelena Vainikonyte-Kristapone, Audrone Seibokaite, Jonas Ceponis, Vygantas Sidlauskas, Laura Daugintyte-Petrusiene, Antanas Norkus, Birute Zilaitiene
The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and antithyroid peroxidase antibody (ATPO) levels, as well as anthropometric and metabolic parameters and smoking information, were evaluated...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28356910/clinicopathological-characteristics-and-prognosis-of-papillary-thyroid-carcinoma-in-naturally-menopausal-women-with-various-durations-of-premenarche-reproductive-periods-and-postmenopausal-stages
#17
Xuhang Zhu, Bin Yu, Yu-Qing Huang, Jing-Nan Zhou, Ming-Hua Ge
Background. Papillary thyroid cancer (PTC) exhibits a higher incidence in women. Due to various ages at menarche and menopause, estrogen levels vary, which may account for the differences in the occurrence, development, and prognosis of female patients with PTC. Objective. The aim of this study was to investigate the association between various durations in different estrogen levels and PTC and to provide important information to guide clinical management and treatment of this disease. Methods. First, we selected naturally menopausal female study subjects diagnosed with PTC at Zhejiang Cancer Hospital from 2007 to 2012 and then compared the differences in clinicopathological characteristics and prognosis among subjects with various lengths of premenarche, reproductive periods, and postmenopausal stages...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28352283/serum-zag-levels-were-associated-with-egfr-mild-decrease-in-t2dm-patients-with-diabetic-nephropathy
#18
Lingling Xu, Weihong Yu, Meng Niu, Caixia Zheng, Bin Qu, Yan Li, Jing Wang, Ping Huang, O Wang, Fengying Gong
Objective. To investigate the changes of serum zinc-α2-glycoprotein (ZAG) in type 2 diabetes mellitus (T2DM) with eGFR mild decrease. Subjects and Methods. A total of 438 T2DM patients (61.3 ± 4.0 y) were recruited and the demographic, anthropometric, and biochemical parameters were all collected. Serum ZAG levels were determined by commercially available ELISA kits. Results. The proportion of T2DM patients with the high tertile ZAG levels was 11.9% higher in patients with mildly decreased estimated glomerular filtration rate (eGFR) (<90 mL/min/1...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28352282/poor-sleep-quality-is-associated-with-dawn-phenomenon-and-impaired-circadian-clock-gene-expression-in-subjects-with-type-2-diabetes-mellitus
#19
Yuxin Huang, Haidong Wang, Yuan Li, Xiaoming Tao, Jiao Sun
Aims. We investigated whether poor sleep quality is associated with both dawn phenomenon and impaired circadian clock gene expression in subjects with diabetes. Methods. 81 subjects with diabetes on continuous glucose monitoring were divided into two groups according to the Pittsburgh Sleep Quality Index. The magnitude of dawn phenomenon was quantified by its increment from nocturnal nadir to prebreakfast. Peripheral leucocytes were sampled from 81 subjects with diabetes and 28 normal controls at 09:00. Transcript levels of circadian clock genes (BMAL1, PER1, PER2, and PER3) were determined by real-time quantitative polymerase chain reaction...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28352281/vitamin-d-deficiency-and-its-determinants-in-adults-a-sample-from-community-based-settings-in-the-united-arab-emirates
#20
Wegdan Bani-Issa, Kamal Eldeirawi, Sondos Harfil, Randa Fakhry
Background. Vitamin D deficiency (VDD) is a public health concern in adults worldwide. This study aims to explore the extent of VDD and its associated factors among adults in the United Arab Emirates (UAE). Subjects and Methods. Quantitative, cross-sectional research was used to assess VDD and its associated factors in 216 adults recruited from randomly selected community-based healthcare settings over a six-month period. Recent values of vitamin D and glycated hemoglobin (HbA1c) were abstracted from medical records, followed by interviews with participants to obtain information on factors related to VDD and other covariates and to measure their heights and weights...
2017: International Journal of Endocrinology
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