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International Journal of Endocrinology

Anna Mazanova, Ihor Shymanskyi, Olha Lisakovska, Lala Hajiyeva, Yulia Komisarenko, Mykola Veliky
Objectives: Recent prospective studies have found the associations between type 1 diabetes (T1D) and vitamin D deficiency. We investigated the role of vitamin D in the regulation of 25OHD-1 α -hydroxylase (CYP27B1) and VDR expression in different tissues of T1D rats. Design: T1D was induced in male Wistar rats by streptozotocin (55 mg/k b.w.). After 2 weeks of T1D, the animals were treated orally with or without vitamin D3 (cholecalciferol; 100 IU/rat, 30 days)...
2018: International Journal of Endocrinology
Xiaopeng Guo, Lu Gao, Xiaodong Shi, Hailong Li, Qiang Wang, Zihao Wang, Wei Chen, Bing Xing
Objective: To investigate the preoperative body composition, metabolic characteristics, and postoperative changes in patients with active acromegaly and analyze the effects of gender and age. Methods: We included 36 patients with untreated acromegaly and 37 patients with nonfunctional pituitary adenomas. Adipose tissue (AT), the visceral fat index (VFI), sclerotin, protein, skeletal muscle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were measured using bioelectrical impedance analysis (BIA)...
2018: International Journal of Endocrinology
Giacomo Tirabassi, Maurizio Sudano, Gianmaria Salvio, Melissa Cutini, Giovanna Muscogiuri, Giovanni Corona, Giancarlo Balercia
Background: The effects of vitamin D on sexual function are very unclear. Therefore, we aimed at evaluating the possible association between vitamin D and sexual function and at assessing the influence of vitamin D administration on sexual function. Methods: We retrospectively studied 114 men by evaluating clinical, biochemical, and sexual parameters. A subsample ( n = 41) was also studied longitudinally before and after vitamin D replacement therapy. Results: In the whole sample, after performing logistic regression models, higher levels of 25(OH) vitamin D were significantly associated with high values of total testosterone and of all the International Index of Erectile Function (IIEF) questionnaire parameters...
2018: International Journal of Endocrinology
Bin Wu, Jingshan Huang, Keisuke Fukuo, Kazuhisa Suzuki, Gen Yoshino, Tsutomu Kazumi
The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor- α (TNF- α ), C-reactive protein (CRP), and systemic oxidative stress marker...
2018: International Journal of Endocrinology
Alfredo Miranda-Martínez, Octavio Fabián Mercado-Gómez, Virginia Arriaga-Ávila, Rosalinda Guevara-Guzmán
Background: Adiponectin (APN) is an adipocyte-derived hormone that has peripheral beneficial effects. Although its receptors AdipoR1 and AdipoR2 are expressed in the brain, their function in neurons is poorly understood. The aims of this work were to describe the distribution of APN receptors in the olfactory bulb (OB) as well as the possible effects of APN injection on the insulin receptor (InsR) content and Akt kinase. Method: We performed the double immunofluorescence technique to describe the distribution of AdipoRs and the cellular type they were expressing...
2017: International Journal of Endocrinology
Mariailaria Verderame, Rosaria Scudiero, Ermelinda Limatola
Spermatogenesis is a fascinating biological process aiming to generate haploid spermatozoa from diploid spermatogonia through a specific hormonal network between gonadotropins and steroids. Increasing evidence suggests that the primary female sex hormone estrogen plays an active role in this process. This research points out on the role of estrogen during lizard spermatogenesis by using three experimental approaches: (1) exposure to an analogue of nonsteroidal estrogen as Clomiphene citrate that acts both as estrogen agonist and antagonist; (2) exposure to the gonadotropin FSH; and (3) exposures to FSH followed by Clomiphene...
2017: International Journal of Endocrinology
Vittorio Unfer, John E Nestler, Zdravko A Kamenov, Nikos Prapas, Fabio Facchinetti
[This corrects the article DOI: 10.1155/2017/8515703.].
2017: International Journal of Endocrinology
Juan Liu, Jianbin Liu, Hai Li, Liehua Liu, Jing Zheng, Zhimin Huang, Xiaopei Cao, Haipeng Xiao, Yanbing Li
Objective: To investigate the relationship between abdominal adipose tissue distribution, β -cell function, and insulin sensitivity (IS) in a Chinese population. Methods: One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied. HOMA-IR, HOMA-B, Matsuda index, early- (I0-30 /G0-30 ) and late-phase (I30-120 /G30-120 ) insulin responses and the corresponding disposition indexes (DI) were calculated...
2017: International Journal of Endocrinology
Julie Refardt, Bettina Winzeler, Fabian Meienberg, Deborah R Vogt, Mirjam Christ-Crain
Objective: Syndrome of inappropriate antidiuresis (SIADH) is the predominant cause of hyponatremia, but treatment options are unsatisfying. SGLT2 inhibitors increase urinary glucose excretion with concomitant osmotic diuresis. We therefore hypothesized SGLT2-inhibitors as a novel treatment for SIADH. Design: Double-blind placebo-controlled randomised crossover study in 14 healthy volunteers. Methods: We induced an artificial SIADH model by administration of desmopressin and overhydration...
2017: International Journal of Endocrinology
Sutin Sriussadaporn, Wanwaroon Pumchumpol, Raweewan Lertwattanarak, Tada Kunavisarut
Background: Previous studies used unequal or high daily dosages of methimazole (MMI) to compare the efficacy of once daily dose regimen (OD-MMI) with that of divided daily doses regimen (DD-MMI) in inducing euthyroidism. Objectives: To compare the efficacy of OD-MMI to that of DD-MMI using low daily dosage of MMI in inducing euthyroidism. Methods: Fifty patients with clinically nonsevere Graves' hyperthyroidism were randomized to be treated with 15 mg/day OD-MMI or 15 mg/day DD-MMI...
2017: International Journal of Endocrinology
Fabricio Ivan Busolini, Graciela Beatriz Rodríguez, Verónica Palmira Filippa, Fabian Heber Mohamed
The presence of pigment has been demonstrated in different nervous structures such as those of retina, substantia nigra, and locus coeruleus. These pigments have also been described in the pineal gland of different mammal species. Histochemical and ultrastructural studies of the pineal gland of female viscacha (Lagostomus maximus maximus) were performed to analyze the presence of pigmented cells under natural conditions and to evaluate a probable relation between pigment content and glandular activity during pregnancy...
2017: International Journal of Endocrinology
Bianca Frauscher, Katharina Artinger, Alexander H Kirsch, Ida Aringer, Foteini Moschovaki-Filippidou, Máté Kétszeri, Corinna Schabhüttl, Peter P Rainer, Albrecht Schmidt, Tatjana Stojakovic, Astrid Fahrleitner-Pammer, Alexander R Rosenkranz, Philipp Eller, Kathrin Eller
Chronic kidney disease (CKD) is associated with mineral and bone disorder (MBD), which is the main cause of the extensively increased cardiovascular mortality in the CKD population. We now aimed to establish a new murine experimental CKD-MBD model. Dilute brown non-Agouti (DBA/2) mice were fed with high-phosphate diet for 4 (HPD4) or 7 (HPD7) days, then with standard chow diet (SCD) and subsequently followed until day 84. They were compared to DBA/2 mice maintained on SCD during the whole study period. Both 4 and 7 days HPD-fed mice developed phosphate nephropathy with tubular atrophy, interstitial fibrosis, decreased glomerular filtration rate, and increased serum urea levels...
2017: International Journal of Endocrinology
Justyna Paprocka, Marek Kijonka, Piotr Wojcieszek, Marcin Pęcka, Ewa Emich-Widera, Maria Sokół
The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n = 9) and in children with (n = 80) and without (n = 40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion. The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and the γ shape parameter allow analyzing the fit and deducing about how much the measured melatonin profile differs from a physiological bell-shaped secretion...
2017: International Journal of Endocrinology
Jia Liu, Yanjin Hu, Yuan Xu, Yumei Jia, Li Miao, Guang Wang
Aims: The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods: The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D who were administrated exenatide or metformin hydrochloride for 12 weeks. Results: 224/230 patients, including 106 in the exenatide group and 118 in the metformin group, completed the 12-week treatment...
2017: International Journal of Endocrinology
Se Hee Park, Sena Hwang, Seunghee Han, Dong Yeob Shin, Eun Jig Lee
Radioactive iodine (RAI) therapy is an effective treatment option for Graves' disease. However, predicting treatment failures after RAI therapy remains controversial. The objective of this study was to investigate the factors associated with the success rate of RAI therapy for treatment of Graves' hyperthyroidism. Thyroid functional outcome, pre-RAI ultrasonographic features, and clinical parameters were evaluated retrospectively in 98 patients followed up for at least 12 months after RAI (mean RAI dose was 11...
2017: International Journal of Endocrinology
Stefano Lello, Anna Capozzi, Giovanni Scambia
The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA). A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women. In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast tenderness, the risk of myocardial infarction, stroke, or venous thromboembolism. Finally, the BZA 20 mg/CE 0.45 mg dose did not increase the risk of endometrial hyperplasia...
2017: International Journal of Endocrinology
Gian Pietro Emerenziani, Maria Chiara Gallotta, Silvia Migliaccio, Emanuela A Greco, Chiara Marocco, Luca di Lazzaro, Rachele Fornari, Andrea Lenzi, Carlo Baldari, Laura Guidetti
No abstract text is available yet for this article.
2017: International Journal of Endocrinology
Goran Kuvačić, Johnny Padulo
No abstract text is available yet for this article.
2017: International Journal of Endocrinology
Wenjun Wu, Xiaohua Gong, Qi Zhou, Xiong Chen, Xiaojun Chen
Background: The aim of this research is to investigate the feasibility of percutaneous ultrasound-guided microwave ablation (MWA) for benign solid thyroid nodules. Methods: Ultrasound-guided percutaneous microwave ablation was performed for 90 benign solid thyroid nodules in 75 patients. The volume changes of the nodules were evaluated before and after microwave ablation, and the cosmetic grading and clinical symptoms were assessed as well. Results: The volume of all the 90 benign thyroid nodules obviously decreased after microwave ablation at 3-, 6-, 9-, and 12-month follow-ups (p < 0...
2017: International Journal of Endocrinology
Jing Cheng, Bing Han, Qin Li, Fangzhen Xia, Hualing Zhai, Ningjian Wang, Michael Jensen, Yingli Lu
Background: The strength of associations between total testosterone (TT) and metabolic parameters may vary in different nature of population structure; however, no study has ever given this information in Chinese population, especially those without metabolic syndrome (MS). We aimed to analyze the association magnitudes between TT and multiple metabolic parameters in general Chinese men. Methods: 4309 men were recruited from SPECT-China study in 2014-2015, which was performed in 22 sites in East China...
2017: International Journal of Endocrinology
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