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Journals International Journal of Gener...

International Journal of General Medicine

https://read.qxmd.com/read/38476627/a-three-year-cross-sectional-analysis-of-depression-anxiety-and-quality-of-life-in-patients-with-post-covid-19-syndrome
#21
JOURNAL ARTICLE
Adrian Vasile Bota, Iulia Bogdan, David Vladut Razvan, Adrian Cosmin Ilie, Raluca Tudor, Mirela Florica Indries, Andrei Nicolae Csep, Iosif Marincu
BACKGROUND: This study explores the longitudinal psychosocial impact of Long-COVID syndrome, also known as Post-COVID-19 syndrome, characterized by enduring symptoms after coronavirus disease (COVID-19) infection, over the years 2020, 2021, and 2022. It aimed to examine the variations in depression, anxiety, and quality of life among Post-COVID-19 patients during these years, hypothesizing significant inter-year differences reflecting the pandemic's evolving influence. METHODS: Conducted at Victor Babes Hospital for Infectious Diseases and Pulmonology, Romania, this cross-sectional research involved 324 patients diagnosed with mild to moderate COVID-19, assessed six months post-hospitalization...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38476626/the-potential-applications-and-challenges-of-chatgpt-in-the-medical-field
#22
REVIEW
Yonglin Mu, Dawei He
ChatGPT, an AI-driven conversational large language model (LLM), has garnered significant scholarly attention since its inception, owing to its manifold applications in the realm of medical science. This study primarily examines the merits, limitations, anticipated developments, and practical applications of ChatGPT in clinical practice, healthcare, medical education, and medical research. It underscores the necessity for further research and development to enhance its performance and deployment. Moreover, future research avenues encompass ongoing enhancements and standardization of ChatGPT, mitigating its limitations, and exploring its integration and applicability in translational and personalized medicine...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38476625/correlations-of-m-6-a-methylation-related-lncrnas-with-the-prognosis-of-papillary-thyroid-carcinoma
#23
JOURNAL ARTICLE
Xiang Li, Zigang Ding, Yun Tong
PURPOSE: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Recurrence makes the prognosis for some patients with PTC worse. Increasing evidence have suggested that N6-methyladenosine (m6 A) RNA methylation plays an important role in tumorigenesis. However, the significance of m6 A-related lncRNAs in the malignant progression of PTC remains unknown. In this study, we explored the significance of M6 A-related lncrnas in the malignant progression of PTC. PATIENTS AND METHODS: Transcriptome and clinical data of PTC were achieved and integrated from The Cancer Genome Atlas (TCGA)...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38476624/the-prevalence-and-associated-factors-of-occupational-stress-in-healthcare-providers-in-saudi-arabia
#24
JOURNAL ARTICLE
Adel F Almutairi, Nasser Ali Hamdan, Saud Altheyabi, Emtinan Abdulrahman Alsaeed, Faisal S Alammari, Ala'a BaniMustafa
BACKGROUND: Occupational stress is a negative physical and emotional response to job requirements, which might be caused by various factors that can harm the emotional and physical well-being of the employee. We aimed to investigate the factors and conditions associated with occupational stress. STUDY DESIGN: The study was cross-sectional, conducted with the Perceived Stress Scale ten item version. RESULTS: The majority of the participants reported moderate stress 223 (71%) and a small proportion (n=38, 12...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38476623/media-search-frequency-source-credibility-about-e-cigarette-health-information-and-motivation-to-quit-ec-among-university-students-in-chengdu-china
#25
JOURNAL ARTICLE
Li Wang, Ching Sin Siau, Nizam Baharom, Mohd Izzuddin Hairol, Lixin Huang, Lei Hum Wee
PURPOSE: E-cigarettes (ECs) are gaining popularity among young people. This study aimed to assess university student vapers' search frequency and source credibility of commonly used media in China, and their association with daily EC users' motivation to quit EC use. PARTICIPANTS AND METHODS: This was a cross-sectional study involving an online quantitative survey in six universities in Chengdu, China. Participants answered questions on their EC use patterns, motivation to quit EC, use frequency and source credibility of media use...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38468821/-jag1-variants-confer-genetic-susceptibility-to-thyroid-dysgenesis-and-thyroid-dyshormonogenesis-in-813-congenital-hypothyroidism-in-china
#26
JOURNAL ARTICLE
Miaomiao Li, Xiaoyu Wang, Fang Wang, Fengqi Wang, Dehua Zhao, Shiguo Liu
BACKGROUND AND OBJECTIVE: Congenital hypothyroidism (CH) is indeed a prevalent neonatal endocrine disorder, affecting approximately 1 in 2000-3000 newborns worldwide, and 1 in 2400 newborns in China. Despite its high incidence, the genetic causes of CH, particularly those related to thyroid dysgenesis (TD), are still not well understood. However, previous studies have suggested that JAG1 may be a potential susceptibility gene for congenital thyroid defects. To explore the association between JAG1 and CH, we screened JAG1 variants in a large cohort of 813 CH patients...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38468820/exploring-symptom-clusters-in-chinese-patients-with-diabetic-kidney-disease-a-network-analysis
#27
JOURNAL ARTICLE
Di-Fei Duan, Min Liu, Deng-Yan Ma, Lin-Jia Yan, Yue-Yang Huang, Yi Chen, Wei Jiang, Xi Tang, An-Qi Xiong, Yun-Ying Shi
PURPOSE: The research on symptom management in patients with diabetic kidney disease (DKD) has shifted from separate symptoms to symptom clusters and networks recently. This study aimed to evaluate the unpleasant symptoms of DKD patients, and to investigate how these symptom clusters could affect patients. METHODS: 408 DKD patients were recruited in this cross-sectional study. The symptoms of DKD patients were measured using the modified Dialysis Symptom Index. Network analysis was employed to evaluate the symptom network and the characteristics of individual nodes, while factor analysis was utilized to identify symptom clusters...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463441/the-predictive-value-of-hemoglobin-to-red-cell-blood-distribution-width-ratio-combined-with-serum-sodium-for-mace-of-acute-heart-failure-with-preserved-ejection-fraction-in-elderly-patients
#28
JOURNAL ARTICLE
Xiaoye Yuan, Caixia Lv, Sisi Wu, Huiying Wang, Xiaoyu Liu
PURPOSE: To investigate the predictive value of hemoglobin (Hb) to red blood cell distribution width (RDW) (Hb/RDW) ratio in combination with serum sodium for major adverse cardiovascular events (MACE) in elderly acute heart failure patients with preserved ejection fraction at 30 days after discharge. METHODS: 130 elderly acute heart failure patients with preserved ejection fraction were enrolled and followed up at 30 days after discharge. They were classified into the MACE group (n=11) and none-MACE group (n=119)...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463440/analysis-of-risk-factors-and-construction-of-a-predictive-model-for-readmission-in-patients-with-coronary-slow-flow-phenomenon
#29
JOURNAL ARTICLE
Changshun Yan, Yankai Guo, Guiqiu Cao
BACKGROUND: Coronary slow flow phenomenon (CSFP) is a phenomenon in which distal vascular perfusion is delayed on angiography, but coronary arteries are not significantly narrowed and there is no other organic cardiac disease. Patients with CSFP may be repeatedly readmitted to the hospital because of chest pain or other symptoms of precordial discomfort, and there is a risk of adverse events. In order to investigate the risk factors affecting the readmission of CSFP patients, a prediction model was constructed with the aim of identifying patients at risk of readmission at an early stage and providing a reference for further clinical intervention...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463439/quantitative-analysis-of-multimodal-mri-markers-and-clinical-risk-factors-for-cerebral-small-vessel-disease-based-on-deep-learning
#30
JOURNAL ARTICLE
Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
BACKGROUND: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. METHODS AND RESULTS: We recruited 211 lacunar stroke patients and 83 control patients. The patients' cerebral small vessel disease markers were automatically segmented using a V-shaped bottleneck network, and the number and volume were calculated after manual correction...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463438/development-and-validation-of-a-novel-predictive-model-for-the-early-differentiation-of-cardiac-and-non-cardiac-syncope
#31
JOURNAL ARTICLE
Sijin Wu, Zhongli Chen, Yuan Gao, Songren Shu, Feng Chen, Ying Wu, Yan Dai, Shu Zhang, Keping Chen
BACKGROUND: The diagnosis of cardiac syncope remains a challenge. This study sought to develop and validate a diagnostic model for the early identification of individuals likely to have a cardiac cause. METHODS: 877 syncope patients with a determined cause were retrospectively enrolled at a tertiary heart center. They were randomly divided into the training set and validation set at a 7:3 ratio. We analyzed the demographic information, medical history, laboratory tests, electrocardiogram, and echocardiogram by the least absolute shrinkage and selection operator (LASSO) regression for selection of key features...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463437/predictive-factors-for-first-pass-intubation-failure-in-trauma-patients
#32
JOURNAL ARTICLE
Katherine Kilkenny, Shea McGrinder, Michael J Najac, Johnathon LeBaron, Pietro Carpenito, Nisha Lakhi
OBJECTIVE: The primary objective of this study was to elucidate risk factors for multiple intubation attempts (MIA) in trauma patients requiring emergent tracheal intubation (ETI). Risk factors for mortality, intensive care unit (ICU) admission, and prolonged ventilation were assessed as secondary outcomes. The association between multiple intubation attempts and adverse outcomes has been well described in the literature. Though previous studies have identified anatomical risk factors for difficult airways, no study to date has investigated predictors for MIA in a trauma setting...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38463436/vaccination-shortens-the-negative-nucleic-acid-conversion-time-of-the-older-population-a-retrospective-cohort-study-of-73-456-asymptomatic-and-mild-patients-with-covid-19-in-shanghai
#33
JOURNAL ARTICLE
Chaoqun Wang, Meng Yang, Guanglin Zhu, Yanyan Hu, Le Shen, Jiaona Qiu, Yi Huang, Libing Wang
PURPOSE: To explore the influencing factors to predict the negative nucleic acid conversion time and ORF1ab gene CT value changes in patients with asymptomatic and mild COVID-19. PATIENTS AND METHODS: A total of 73,456 patients with asymptomatic and mild COVID-19 admitted to the Mobile Cabin Hospital in Shanghai from April 3 to April 23, 2022 were selected as the research objects. Epidemiological, clinical, and laboratory data were collected. Correlation analysis was performed...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435117/exploring-the-molecular-mechanisms-and-shared-gene-signatures-between-systemic-lupus-erythematosus-and-bladder-urothelial-carcinoma
#34
JOURNAL ARTICLE
Kongjia Wang, Shufei Wang, Yixin Ding, Zengshun Kou, Bo Jiang, Sichuan Hou
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with increased susceptibility to cancer, including bladder urothelial carcinoma (BLCA). This study investigates the shared molecular mechanisms and gene signatures between SLE and BLCA, shedding light on potential biomarkers and therapeutic targets. METHODS: We compiled gene datasets related to SLE and BLCA from various databases and identified common genes. Differential gene expression analysis, protein-protein interaction networks, and hub gene identification were performed...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435116/vulvar-hidradenoma-papilliferum
#35
JOURNAL ARTICLE
Lixin Wang, Gang Chen, Jingui Jiang, Guoyan Liu, Ying-Lan Tuo, Xiaohong Li, Weishan Zhang
AIM: This study examines the clinical and pathological characteristics, immune profile, histological occurrence, diagnosis, and differential diagnosis of vulvar hidradenoma papilliferum. METHODS: An analysis was conducted on clinical data, histological patterns, and immunohistochemical findings from 45 cases of vulvar hidradenoma papilliferum, and relevant published articles were reviewed. Simultaneously, high-risk HPV typing was performed on these 45 cases. RESULTS: The 45 cases of vulvar hidradenoma papilliferum displayed tumor sizes ranging from 0...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435115/overlap-between-gastroesophageal-reflux-disease-and-functional-constipation-and-associated-risk-factors-among-the-general-population-in-saudi-arabia
#36
JOURNAL ARTICLE
Bashaeer Abdullh Al Jalal, Ahmed Khalid Alnawah, Fahad Mohammed Alturkie, Khalid Jafar Alqadhib, Mohammed Sami Alabbadi, Sayed Ibrahim Ali, Hessah Abdulaziz Al Hussaini
INTRODUCTION: Gastroesophageal reflux disease (GERD) and functional constipation (FC) are two common gastrointestinal disorders that affect many age groups in the community. A few studies were conducted to find the association between GERD and FC, but no study had been conducted in Saudi Arabia. Therefore, this study aims to find the overlap between GERD and FC and associated risk factors among the general population in the Eastern Province, Saudi Arabia. METHODS: A cross-sectional study was conducted in the eastern province of Saudi Arabia between August and September 2022...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435114/increased-pd-1-nk-cell-subset-in-the-older-population
#37
JOURNAL ARTICLE
Meiju Deng, Yongqin Zeng, Ying Liu, Xiaolei Wang, Na Chen, Mengyuan Zhang, Meiqing Jiang, Hongxin Zhao, Juan Du
BACKGROUND: The aging of the immune system is associated with various diseases. It is worth exploring the changes of the immune system in aging. Previous studies have shown that aged T cells have enhanced expression of co-inhibitory molecules. However, it remains unclear whether aged NK cells exhibit similar characteristics to aged T cells. The objective of our research was to clarify this aspect. PATIENTS AND METHODS: This study included 98 adults aged 24-90 years (50 males and 48 females)...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435113/predictive-value-of-mhr-and-nlr-for-ulcerative-colitis-disease-activity
#38
JOURNAL ARTICLE
Tian Liu, Zhenkun Qin, Zhiyue Yang, Xiaoling Feng
BACKGROUND: Numerous non-invasive serologic tests are available to diagnose and monitor ulcerative colitis (UC), but their accuracy levels are limited. Thus, there is a pressing need for a serologic biomarker with higher precision for clinical practice. This study aims to evaluate the predictive capacity of monocyte/HDL ratio (MHR) and neutrophil/lymphocyte ratio (NLR) for UC disease activity. PATIENTS AND METHODS: We conducted a retrospective analysis of 81 UC patients and 77 age- and sex-matched healthy controls...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38435112/determinants-and-prognoses-of-visual-functional-mismatches-after-mechanical-reperfusion-in-st-elevation-myocardial-infarction
#39
JOURNAL ARTICLE
Jieliang Liu, Junguo Jin, Bingyan Yu, Shanghong Zhang, Xiaoqi Lu, Guoqiang Chen, Yi Yang, Haojian Dong
BACKGROUND: Discordance between the anatomy and physiology of the coronary has important implications for managing patients with stable coronary disease, but its significance in ST-elevation myocardial infarction has not been fully elucidated. METHODS: The retrospective study involved patients diagnosed with ST-elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI), along with quantitative coronary angiography (QCA) and quantitative flow ratio (QFR) assessments...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38414629/bioinformatics-analysis-and-experimental-validation-of-mitochondrial-autophagy-genes-in-knee-osteoarthritis
#40
JOURNAL ARTICLE
Kuihan Tang, Li Sun, Long Chen, Xiaobo Feng, Jiarui Wu, Hao Guo, Yong Zheng
BACKGROUND: Mitochondrial autophagy is closely related to the pathogenesis of osteoarthritis, In order to explore the role of mitochondrial autophagy related genes in knee osteoarthritis (KOA) and its molecular mechanism. METHODS: KOA-related transcriptome data were extracted from the Gene Expression Omnibus (GEO) database. Differentially expressed mitochondrial autophagy gene (DEMGs) were screened in patients with KOA by differential expression analysis. The STRING website was used to construct a protein-protein interaction (PPI) network among DEMGs...
2024: International Journal of General Medicine
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