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International Journal of General Medicine

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https://www.readbyqxmd.com/read/30214268/received-care-compared-to-adp-guided-care-of-patients-admitted-to-hospital-with-chest-pain-of-possible-cardiac-origin
#1
Michael Perera, Leena Aggarwal, Ian A Scott, Bentley Logan
Purpose: To assess the extent to which accelerated diagnostic protocols (ADPs), compared to traditional care, identify patients presenting to emergency departments (EDs) with chest pain who are at low cardiac risk and eligible for early ED discharge. Patients and methods: Retrospective study of 290 patients admitted to hospital for further evaluation of chest pain following negative ED workup (no acute ischemic electrocardiogram [ECG] changes or elevation of initial serum troponin assay)...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30197531/acromegaly-a-challenging-condition-to-diagnose
#2
REVIEW
Salma AlDallal
Acromegaly is an uncommon, chronic disease, characterized by hypersecretion of a pituitary growth hormone by somatotroph adenomas, along with increased levels of insulin-like growth factor-1. Although acromegaly presents a wide array of clinical manifestations, the salient symptoms include acral and soft tissue enlargement, joint pain, heart and respiratory failure, diabetes mellitus, and hypertension, leading to increased morbidity and mortality. Hence, early diagnosis of the disease is critical to enhance life expectancy and quality of life...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30197530/role-of-intravenous-iron-in-the-treatment-of-anemia-in-patients-with-gastrointestinal-tract-tumors-undergoing-chemotherapy-a-single-center-observational-study
#3
Joana Lima, Patrícia Gago, Mariana Rocha, Inês Grilo, Rosa Gomes, Michael Luís, Teresa Sarmento, Antonio Teira, Marta Sousa, Miguel Barbosa
Purpose: The prevalence of anemia ranges between 30% and 90% in cancer patients, affecting the health status, quality of life, and treatment outcome. Therefore, a proper diagnosis and management of anemia is crucial in these patients. Iron deficiency is diagnosed in~32%-60% of the cases. In this observational study, we evaluated the efficacy and safety of intravenous iron (ferric carboxymaltose [FCM], Ferinject® ) in the treatment of iron-deficiency anemia in patients with gastrointestinal tumors undergoing palliative or adjuvant chemotherapy...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30127634/clinical-utility-of-plecanatide-in-the-treatment-of-chronic-idiopathic-constipation
#4
REVIEW
Bianca N Islam, Sarah K Sharman, Darren D Browning
Constipation is an important health burden that reduces the quality of life for countless millions of people. Symptom-centric therapeutics are often used to treat constipation due to unknown etiology, but in many cases, these drugs are either inadequate or have significant side effects. More recently, synthetic peptide agonists for epithelial guanylyl cyclase C (GC-C) have been developed which are effective at treating constipation in a sub-population of adult constipation patients. The first to market was linaclotide that is structurally related to the diarrheagenic enterotoxin, but this was followed by plecanatide, which more closely resembles endogenous uroguanylin...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30050317/expert-opinion-on-the-applicability-of-dyslipidemia-guidelines-in-asia-and-the-middle-east
#5
EDITORIAL
Mostafa Alshamiri, Mahmood Mohammed Ali Ghanaim, Philip Barter, Kuan-Cheng Chang, Jian-Jun Li, Bien J Matawaran, Anwar Santoso, Sameh Shaheen, Ketut Suastika, Nuntakorn Thongtang, Ahmad Km Yusof
Cardiovascular disease (CVD) is a growing burden across the world. In Asia and the Middle East, in particular, CVD is among the most prevalent and debilitating diseases. Dyslipidemia is an important factor in the development of atherosclerosis and associated cardiovascular events, and so effective management strategies are critical to reducing overall cardiovascular risk. Multiple dyslipidemia guidelines have been developed by international bodies such as the European Society of Cardiology/European Atherosclerosis Society and the American College of Cardiology/American Heart Association, which all have similarities in practice recommendations for the optimal management of dyslipidemia...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30038516/fever-of-unknown-origin-following-parathyroidectomy-prior-to-onset-of-typical-polymyalgia-rheumatica-symptoms-a-case-report
#6
Akinori Kanzaki, Kiyoshi Matsui, Tadahiko Sukenaga, Koushi Mase, Aya Nishioka, Tomoharu Tamori, Seiko Kataoka, Hiroyuki Konya, Shin Mizutani, Akira Takeda, Masato Koseki, Tetsuo Nishiura, Hidenori Koyama, Hajime Sano
Polymyalgia rheumatica (PMR) is a disease commonly seen in elderly individuals, however, the etiology has not been reported. Typical clinical features include bilateral shoulder pain and morning stiffness, while serologic autoantibody test findings are negative. Approximately 40%-50% of affected patients present with low-grade fever, fatigue, and appetite loss, which we often experience in the field of general medicine, and thus, the condition should not be given low priority. However, knowledge regarding such constitutional manifestations is also limited...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30038515/a-unique-finding-of-cavum-velum-interpositum-colloid-like-cyst-and-literature-review-of-a-commonplace-lesion-in-an-uncommon-place
#7
Abdulaziz Mohammad Al-Sharydah, Sari Saleh Al-Suhibani, Abdulrahman Hamad Al-Abdulwahhab, Mohammad Saad Al-Aftan, Ahmad Fouad Gashgari
Colloid cysts typically reside within the area of the anterior third ventricle, in the proximity of the foramen of Monro. Although they are considered to commonly localize in various parts of the cerebrum, they are exceedingly rare outside the ventricular system and rarely occur within the velum interpositum. We have reported here a rare case of a velum interpositum colloid-like cyst in a 23-year-old man, who presented to our clinic with temporary binocular strabismus, which he had been experiencing for the previous year...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30034248/clinical-and-microbiological-characteristics-and-occurrence-of-klebsiella-pneumoniae-infection-in-japan
#8
Mahoko Ikeda, Miyuki Mizoguchi, Yukie Oshida, Keita Tatsuno, Ryoichi Saito, Mitsuhiro Okazaki, Shu Okugawa, Kyoji Moriya
Purpose: Klebsiella pneumoniae is a pathogen that causes pneumonia and urinary tract infection. Hypervirulent K. pneumoniae strains often show hypermucoviscosity, are of the K1 or K2 serotype, and harbor the rmpA and magA genes. However, the differences in the prevalence of K. pneumoniae with these hypervirulent characteristics between the infection and colonization status are not well understood. Therefore, in this study, we compared the clinical and microbiological characteristics of K...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30013383/altered-levels-of-cytokines-in-patients-with-irritable-bowel-syndrome-are-not-correlated-with-fatigue
#9
Ellen Johanne Vara, Karl A Brokstad, Trygve Hausken, Gülen Arslan Lied
Introduction: A considerable number of patients with gastrointestinal complaints attributable to irritable bowel syndrome (IBS) have shown evidence of immune activation. Fatigue is also frequently reported by IBS patients and the condition is considered as a common comorbidity of IBS. Therefore, it is interesting to see whether these two conditions share the same pathophysiological mechanism. Aims: To investigate the potential role of cytokine profiles in patients with IBS and the relationship between cytokine profiles and fatigue...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30013382/development-of-a-nasal-spray-containing-xylometazoline-hydrochloride-and-iota-carrageenan-for-the-symptomatic-relief-of-nasal-congestion-caused-by-rhinitis-and-sinusitis
#10
Christine Graf, Andreas Bernkop-Schnürch, Alena Egyed, Christiane Koller, Eva Prieschl-Grassauer, Martina Morokutti-Kurz
Introduction: Xylometazoline hydrochloride (HCl) is a nasal decongestant that causes vasoconstriction in the nasal submucosa. It has been used for more than 50 years for the treatment of nasal congestion caused by rhinitis/sinusitis. Iota-carrageenan is effective against a broad variety of respiratory viruses, which are the most common cause of infections of the upper respiratory tract. Therefore, it is used as the active component in the antiviral nasal spray Coldamaris prophylactic (1...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/30013381/evaluating-the-use-of-corticosteroids-in-preventing-and-treating-bronchopulmonary-dysplasia-in-preterm-neonates
#11
REVIEW
Oreoluwa Olaloko, Raihan Mohammed, Utkarsh Ojha
Approximately 15 million babies worldwide are born premature, and complications of prematurity are one of the leading causes of death in neonates. Neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD) are two of the most common and serious consequences of prematurity. Synthetic corticosteroids, including dexamethasone, have been central in efforts to treat and prevent BPD. There is strong evidence to show that prenatal corticosteroids reduce infant mortality and the incidence of NRDS, leading to their widespread use in obstetric units...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29988742/the-increasing-prevalence-of-non-communicable-diseases-in-low-middle-income-countries-the-view-from-malawi
#12
REVIEW
Matthew Gowshall, Simon D Taylor-Robinson
Non-communicable diseases (NCDs) are the leading cause of death globally, the majority of these being due to cardiovascular disease, cancer, chronic respiratory diseases, or diabetes. Mortality from many NCDs continues to increase worldwide, with a disproportionately larger impact in low-middle income countries (LMIs), where almost 75% of global deaths occur from these causes. As a low-income African country that consistently ranks amongst the world's poorest nations, Malawi as a case study demonstrates how transition due to societal change and increasing urbanization is often accompanied by a rise in the rate of NCDs...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29950885/understanding-short-term-blood-pressure-variability-phenotypes-from-concept-to-clinical-practice
#13
REVIEW
Veerendra Melagireppa Chadachan, Min Tun Ye, Jam Chin Tay, Kannan Subramaniam, Sajita Setia
Clinic blood pressure (BP) is recognized as the gold standard for the screening, diagnosis, and management of hypertension. However, optimal diagnosis and successful management of hypertension cannot be achieved exclusively by a handful of conventionally acquired BP readings. It is critical to estimate the magnitude of BP variability by estimating and quantifying each individual patient's specific BP variations. Short-term BP variability or exaggerated circadian BP variations that occur within a day are associated with increased cardiovascular events, mortality and target-organ damage...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29950884/stroke-in-hospital-survival-and-its-predictors-the-first-results-from-tabriz-stroke-registry-of-iran
#14
Reza Deljavan, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani
Objective: The aim of this study was to determine the in-hospital survival of patients referred to the 2 stroke centers in North-West of Iran during a full seasonal year from April 2015. Methods: All the consecutive patients with stroke admitted to the 2 main stroke centers at Tabriz (Imam Reza University Hospital and Razi University Hospital) were recruited in this study. Stroke patients from both ischemic and hemorrhagic subtypes were selected based on the registry data and International Classification of Diseases, 10th edition...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29950883/venous-thromboembolism-risk-assessments-on-trauma-patients-has-suboptimal-interobserver-reliability-among-inexperienced-clinicians-fourth-year-medical-students
#15
Akella Chendrasekhar, Sireesha Aleti
Background: Venous thromboembolic disease is a major cause of morbidity and mortality in hospitalized patients worldwide. The objective of this study is to compare interobserver reliability for qualitative and quantitative venous thromboembolism (VTE) risk assessments in hospitalized trauma patients. Methods: We conducted a retrospective medical record review of 40 randomly selected trauma patients admitted to a 448-bed urban level-I trauma center from January 2013 to January 2014...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29942144/association-of-serum-procalcitonin-and-c-reactive-protein-levels-with-curb-65-criteria-among-patients-with-community-acquired-pneumonia
#16
Fariba Keramat, Hamid Reza Ghasemi Basir, Elham Abdoli, Arghavan Shafiei Aghdam, Jalal Poorolajal
Background: The concentration of diagnostic markers such as inflammatory biomarkers including procalcitonin (PCT) and C-reactive protein (CRP) increases in bacterial infections. The aim of this study was to compare serum PCT and CRP levels with CURB-65 ranking, in the patients with community-acquired pneumonia (CAP). Patients and methods: In a cross-sectional study, 93 hospitalized patients with a definite diagnosis of CAP, considering inclusion and exclusion criteria, were enrolled...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29892202/clinical-and-epidemiologic-profile-and-predictors-of-outcome-of-poisonous-snake-bites-an-analysis-of-1-500-cases-from-a-tertiary-care-center-in-malabar-north-kerala-india
#17
Kg Sajeeth Kumar, Santhosh Narayanan, V Udayabhaskaran, N K Thulaseedharan
Background: Snake bites are a neglected public health problem in all tropical countries, and particularly in Malabar region of Kerala, India. Demographic characteristics and clinical parameters vary in this part of the world, and studies based on them are scarce. Increased incidence of capillary leak syndrome (CLS) in hemotoxic snake bites and emergence of cases of hump-nosed pit viper (HNPV, Hypnale hypnale ) envenomation are some notable features seen here. Objectives: The study was conducted to assess the epidemiological profile and clinical features to identify factors contributing to outcome in patients with venomous snakebites...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29872334/overview-of-air-pollution-and-endocrine-disorders
#18
REVIEW
Philippa D Darbre
Over recent years, many environmental pollutant chemicals have been shown to possess the ability to interfere in the functioning of the endocrine system and have been termed endocrine disrupting chemicals (EDCs). These compounds exist in air as volatile or semi-volatile compounds in the gas phase or attached to particulate matter. They include components of plastics (phthalates, bisphenol A), components of consumer goods (parabens, triclosan, alkylphenols, fragrance compounds, organobromine flame retardants, fluorosurfactants), industrial chemicals (polychlorinated biphenyls), products of combustion (polychlorinated dibenzodioxins/furans, polyaromatic hydrocarbons), pesticides, herbicides, and some metals...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29844698/exploring-factors-that-might-influence-primary-care-provider-discussion-of-and-recommendation-for-prostate-and-colon-cancer-screening
#19
Christine E Kistler, Maihan Vu, Anne Sutkowi-Hemstreet, Ziya Gizlice, Russell P Harris, Noel T Brewer, Carmen L Lewis, Rowena J Dolor, Colleen Barclay, Stacey L Sheridan
Background: Primary-care providers may contribute to the use of low-value cancer screening. Objective: We sought to examine circumstances under which primary-care providers would discuss and recommend two types of cancer screening services across a spectrum of net benefit and other factors known to influence screening. Patients and methods: This was a cross sectional survey of 126 primary-care providers in 24 primary-care clinics in the US...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29773952/remote-ischemic-preconditioning-in-myocardial-protection-in-hemodialysis-patients
#20
Marcelo R Bacci, Livia Y Vasconcelos, Neif Murad, Antonio Carlos P Chagas, Ana Carolina Capuano, Beatriz Ca Alves, Edimar C Pereira, Ligia A Azzalis, Virginia Bc Junqueira, Fernando LA Fonseca
Background: Remote ischemic preconditioning (RIPC) is a procedure that generates a brief period of ischemia followed by reperfusion. The role of RIPC in protecting myocardial ischemia during hemodialysis is not yet established. The aim of the study was to evaluate RIPC myocardial protection as evaluated by ultrasensitive I troponin in hemodialysis outpatients. Patients and methods: A double-blind randomized trial with two groups: intervention submitted to RIPC and control group without RIPC...
2018: International Journal of General Medicine
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