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OncoTargets and Therapy

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https://www.readbyqxmd.com/read/28096685/the-role-of-microrna-21-in-predicting-brain-metastases-from-non-small-cell-lung-cancer
#1
Jing Dong, Zhi Zhang, Tao Gu, Shu-Feng Xu, Li-Xin Dong, Xin Li, Bao-Hong Fu, Zhan-Zhao Fu
OBJECTIVE: This study aimed at exploring the role of microRNA-21 (miR-21) in predicting brain metastases (BM) from non-small cell lung cancer (NSCLC). METHODS: A total of 132 NSCLC patients, including 68 patients with BM and 64 patients without BM, were included in the study. NSCLC cells were collected and assigned to the inhibitor (IN) group, the mock group, and the negative control (NC) group. The quantitative real-time polymerase chain reaction assay was used to detect the miR-21 expression...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28096684/pediatric-papillary-thyroid-cancer-current-management-challenges
#2
REVIEW
Frederik A Verburg, Hanneke M Van Santen, Markus Luster
Although with a standardized incidence of 0.54 cases per 100,000 persons, differentiated thyroid cancer (DTC) is a rare disease in children and adolescents, it nonetheless concerns ~1.4% of all pediatric malignancies. Furthermore, its incidence is rising. Due to the rarity and long survival of pediatric DTC patients, in most areas of treatment little evidence exists. Treatment of pediatric DTC is therefore littered with controversies, many questions therefore remain open regarding the optimal management of pediatric papillary thyroid cancer (PTC), and many challenges remain unsolved...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28096683/clinicopathological-and-immunohistochemical-features-of-lung-invasive-mucinous-adenocarcinoma-based-on-computed-tomography-findings
#3
Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Ai Maeda, Yuji Nojima, Masao Nakata
BACKGROUND: We performed an analysis to clarify differences in clinicopathological and molecular features of lung invasive mucinous adenocarcinoma (IMA) based on computed tomography (CT) findings and their impact on prognosis. PATIENTS AND METHODS: On the basis of CT findings, we divided lung IMA into three subtypes: solid, bubbling, and pneumonic. We then investigated differences in clinicopathological characteristics, prognosis, and the expressions of well-identified biomarkers, including cyclooxygenase-2 (Cox-2), excision repair cross-complementation group 1 (ERCC1), ribonucleotide reductase M1 (RRM1), class III beta-tubulin, thymidylate synthase (TS), secreted protein acidic and rich in cysteine (SPARC), programmed cell death-1 ligand-1 (PD-L1), and epidermal growth factor receptor mutation, among the three subtypes...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28096682/decreased-mir-503-expression-in-gastric-cancer-is-inversely-correlated-with-serum-carcinoembryonic-antigen-and-acts-as-a-potential-prognostic-and-diagnostic-biomarker
#4
Daoyi Wu, Gaojian Cao, Zhenfeng Huang, Kai Jin, Haowei Hu, Jie Yu, Yu Zeng
BACKGROUND: Altered expression of miR-503 has been linked to human carcinogenesis. In this present study, we aimed to detect the potential for miR-503 as a novel biomarker for gastric cancer (GC) patients. MATERIALS AND METHODS: The relative mRNA level of miR-503 in serum and tissue of 68 GC patients and serum of 32 healthy volunteers was determined by real-time reverse transcription quantitative polymerase chain reaction. RESULTS: The miR-503 level was significantly lower in the tissue and serum of GC than their counterparts (all P<0...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053548/recombinant-human-endostatin-in-combination-with-chop-regimen-for-peripheral-t-cell-lymphoma
#5
Qunling Zhang, Junning Cao, Kai Xue, Xiaojian Liu, Dongmei Ji, Ye Guo, Xiaonan Hong
Peripheral T cell lymphoma (PTCL) has a poor prognosis. Overexpression of vascular endothelial growth factor (VEGF) might contribute to the poor prognosis of PTCL and could be the target of novel therapy. The efficacy and safety of recombinant human endostatin (Endostar) in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (ECHOP) have been explored in 15 PTCL patients. The objective response rate was 80%, with 53.3% patients having achieved complete response (CR) rate. The CR rate was 100% (3/3) in angioimmunoblastic T cell lymphoma (AITL) patients compared to only 36...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053547/anticancer-activities-of-epigallocatechin-3-gallate-against-cholangiocarcinoma-cells
#6
Tae Won Kwak, Su Bum Park, Hyun-Jung Kim, Young-Il Jeong, Dae Hwan Kang
PURPOSE: Epigallocatechin-3-gallate (EGCG) is an antioxidant agent derived from green tea. Because it has chemopreventive and anti-invasive effect against various cancer cells, EGCG can be used to inhibit proliferation and invasion of cholangiocarcinoma (CCA) cells. METHODS: The anticancer effects of EGCG were studied using human CCA cells (HuCC-T1). Apoptosis was analyzed by Western blotting. Invasion and migration of cancer cells were assessed with Matrigel(®) and wound healing assays...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053546/comparing-efficacy-and-survivals-of-initial-treatments-for-elderly-patients-with-newly-diagnosed-multiple-myeloma-a-network-meta-analysis-of-randomized-controlled-trials
#7
Xiaoping Liu, Jiarui Chen, Yuncen A He, Xiangyu Meng, Kaili Li, Colin K He, Shangqin Liu
OBJECTIVE: The aim of this study was to evaluate the efficacy and clinical outcome of initial therapies for elderly patients with multiple myeloma (MM). METHODS: Randomized controlled trials (RCTs) were obtained through a comprehensive search. Response rate, progression-free survival (PFS) and overall survival (OS) were the interested outcome measures. Network meta-analysis (NMA) using graph theory methodology to construct an NMA model, and sensitivity analysis were performed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053545/high-expression-of-long-noncoding-rna-hulc-is-a-poor-predictor-of-prognosis-and-regulates-cell-proliferation-in-glioma
#8
Hong Yan, Rui Tian, Min Zhang, Jing Wu, Min Ding, Jie He
PURPOSE: Emerging studies show that long noncoding RNAs (lncRNAs) have important roles in carcinogenesis. This study investigated the role of lncRNA highly upregulated in liver cancer (HULC) expression in glioma and its clinical significance in glioma patients. MATERIALS AND METHODS: HULC expression was detected in glioma tissues and cell lines by using real-time quantitative reverse transcription polymerase chain reactions. Association between HULC levels and clinicopathological factors and patients prognosis was also analyzed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053544/nab-paclitaxel-as-a-potential-partner-with-checkpoint-inhibitors-in-solid-tumors
#9
REVIEW
Hatem H Soliman
Tumors recognized by the host immune system are associated with better survival. However, the immune system is often suppressed in patients with established tumor burden. Stimulating the immune system to detect and kill tumor cells has been a challenge in cancer therapy for some time. Recently, novel cancer immunotherapies, such as immune checkpoint inhibitors, monoclonal antibodies, and vaccine therapies, have emerged as promising therapeutic approaches for many solid tumors. However, for some tumors, immunotherapy alone has not provided significant benefits, and some may even be fully resistant to immunotherapy...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053543/expression-of-hpip-in-epithelial-ovarian-carcinoma-a-clinicopathological-study
#10
Yuping Wang, Fanling Meng, Yunduo Liu, Xiuwei Chen
OBJECTIVES: Hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP) plays an important role in cancer invasion and metastasis. The aim of this study is to investigate the expression of HPIP in epithelial ovarian cancer (EOC). PATIENTS AND METHODS: Immunohistochemical method was performed using 42 normal ovarian specimens and 145 specimens with EOC. The correlations of HPIP expression with the clinicopathological factors and prognosis of EOC patients were evaluated...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053542/reduction-of-azgp1-predicts-poor-prognosis-in-esophageal-squamous-cell-carcinoma-patients-in-northern-china
#11
Hong Tang, Yufeng Wu, Yanru Qin, Haiying Wang, Lili Wang, Xinyuan Guan, Suxia Luo, Qiming Wang
BACKGROUND: As a key regulator in lipid mobilization, AZGP1 has been reported to play a significant role in various cancers. This study was carried out to investigate the role of AZGP1 in the development of esophageal squamous cell carcinoma (ESCC) patients in Northern China. MATERIALS AND METHODS: Through the application of quantitative real-time polymerase chain reaction and immunohistochemical staining, AZGP1 expression in ESCC tissues from Northern China was examined...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053541/nasopharyngeal-carcinoma-treated-with-bevacizumab-combined-with-paclitaxel-liposome-plus-cisplatin-a-case-report-and-literature-review
#12
Wan He, Chang Zou, Zhongkai Tian, Wenyong Tan, Weixi Shen, Jinghua Chen, Liping Liu, Ruilian Xu
Patients with stage IV nasopharyngeal carcinoma (NPC) have a poor prognosis, even with effective chemotherapy. Target agents combined with chemotherapy may improve NPC patients' outcome. The case of a patient with NPC, who was treated by adding bevacizumab to chemotherapy after disease progression using first-line chemotherapy, is reported. Recently published literature about effects of combining bevacizumab with standard chemotherapy in NPC cell lines or patients are also reviewed and discussed. Consistent with a few preclinical trials and Phase II clinical trials, bevacizumab may reverse the drug resistance to chemotherapy, and its toxic side effects are well tolerated...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28053540/a-novel-synthetic-asiatic-acid-derivative-induces-apoptosis-and-inhibits-proliferation-and-mobility-of-gastric-cancer-cells-by-suppressing-stat3-signaling-pathway
#13
Gang Wang, Yue Jing, Lingsen Cao, Changchang Gong, Zhunan Gong, Xiangrong Cao
Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly, agents that can suppress STAT3 activation have the potential for use in the prevention and treatment of various cancers. In this study, an Asiatic acid (AA) derivative, N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-l-proline methyl ester (AA-PMe), is reported to dose dependently suppress constitutive STAT3 activation in gastric cancer cells...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031722/low-plce1-levels-are-correlated-with-poor-prognosis-in-hepatocellular-carcinoma
#14
Ya Cheng, Song-Ge Xing, Wei-Dong Jia, Mei Huang, Na-Na Bian
BACKGROUND: Previous reports show that phospholipase C epsilon-1 (PLCE1) expression is positively correlated with esophageal squamous cell carcinoma and gastric cardia adenocarcinomas; however, the expression of PLCE1 in hepatocellular carcinoma (HCC) and its correlation with clinical outcome still remain unclear. The aim of this study was to explore the expression of PLCE1 in HCC tissue and to determine whether PLCE1 was a prognostic factor for HCC patients. MATERIALS AND METHODS: PLCE1 levels in 20 paired HCC tissues and corresponding paracarcinomatous tissues was investigated by quantitative real-time polymerase chain reaction and Western blot assays...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031721/long-noncoding-rna-malat1-regulated-microrna-506-modulates-ovarian-cancer-growth-by-targeting-iaspp
#15
Ruilin Lei, Min Xue, Lan Zhang, ZhongQiu Lin
MALAT1, an important cancer-associated long noncoding RNA (lncRNA), contributes to the development and progression of several cancers. Disordered expression of MALAT1 has been observed in several cancers, including cervical cancer, breast cancer, and ovarian cancer. However, the exact effects and molecular mechanisms of MALAT1 in ovarian cancer progression are still unknown. Here, we investigated the role of MALAT1 in human ovarian cancer cell lines and clinical tumor samples, in order to determine the function of this molecule...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031720/atypical-aleukemic-presentation-of-large-granular-lymphocytic-leukemia-a-case-report
#16
Cristina Bagacean, Adrian Tempescul, Mariana Patiu, Bogdan Fetica, Horia Bumbea, Mihnea Zdrenghea
Large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder of transformed natural killer or T-cells attributed to chronic exposure to the proinflammatory cytokine IL-15. Diagnosis of the majority of T-cell LGLL is established by documenting clonal large granular lymphocytes (LGLs) in peripheral blood, by morphology and immunophenotype. The proteasome inhibitor bortezomib is known to target molecular pathways downstream of the IL-15 receptor signaling and has been proposed as a therapy in these patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031719/potential-role-of-immunotherapy-in-advanced-non-small-cell-lung-cancer
#17
REVIEW
Ramon Andrade de Mello, Ana Flávia Veloso, Paulo Esrom Catarina, Sara Nadine, Georgios Antoniou
Immuno checkpoint inhibitors have ushered in a new era with respect to the treatment of advanced non-small-cell lung cancer. Many patients are not suitable for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (eg, gefitinib, erlotinib, and afatinib) or with anaplastic lymphoma kinase inhibitors (eg, crizotinib and ceritinib). As a result, anti-PD-1/PD-L1 and CTLA-4 inhibitors may play a novel role in the improvement of outcomes in a metastatic setting. The regulation of immune surveillance, immunoediting, and immunoescape mechanisms may play an interesting role in this regard either alone or in combination with current drugs...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031718/j-pouch-versus-roux-en-y-reconstruction-after-gastrectomy-functional-assessment-and-quality-of-life-randomized-trial
#18
Pavel Zonča, Tomáš Malý, Peter Ihnát, Matus Peteja, Otakar Kraft, Kamil Kuca
PURPOSE: The aim of this study was to evaluate the quality of life and functional emptying of J-pouch versus Roux-en-Y reconstruction after total gastrectomy for malignancy. METHODS: This study was designed as a prospective, nonblinded, randomized, parallel clinical trial (Trial Number: MN Ostrava, 200604). With informed consent, patients undergoing gastrectomy for malignancy were randomized to J-pouch or Roux-en-Y reconstruction. The time taken for a test semisolid meal labeled with (99m)Tc-sulfur colloid to exit the reconstructed parts was measured by dynamic scintigraphy 1 year after resection...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28031717/association-between-tlr-9-polymorphisms-and-colon-cancer-susceptibility-in-saudi-arabian-female-patients
#19
Abdelhabib Semlali, Narasimha Reddy Parine, Abdullah Al Amri, Arezki Azzi, Maha Arafah, Muhammad Kohailan, Jilani P Shaik, Majid Abdulrahman Almadi, Abdulrahman M Aljebreen, Othman Alharbi, Nahla Ali Azzam, Mahmoud Rouabhia, Mohammad Saud Alanazi
OBJECTIVE: The authors aimed to explore the relationship between the expression/polymorphisms of TLR-9 and susceptibility to colon cancer development in the Saudi Arabian population. METHODS: In total, blood samples from 115 patients with colon cancer and 102 participants without colon cancer were analyzed in this study. Three single-nucleotide polymorphisms (SNPs) were selected from the TLR-9 gene, including two sites within the TLR-9 gene's promoter region (rs352144 and rs187084) and one site in a TLR-9 intron region (rs5743839)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28008276/non-secretory-multiple-myeloma-from-biology-to-clinical-management
#20
REVIEW
Megan Murray Dupuis, Sascha A Tuchman
Multiple myeloma (MM) is the second most common hematologic malignancy in the US. It is typically characterized by production of large amounts of defective immunoglobulin (Ig). Diagnosing MM and monitoring treatment response, including eventual relapse, are largely based on sequential measurements of Ig. However, a small subset of MM called non-secretory multiple myeloma (NSMM) produces no detectable Ig. This subset of true NSMM has become even smaller over time, as the advent of the serum free light chain assay has resulted in the majority of NSMM patients being recategorized as light-chain MM - that is, MM cells that produce only the light-chain component of Ig...
2016: OncoTargets and Therapy
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