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Virologica Sinica

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https://www.readbyqxmd.com/read/28918477/in-vitro-inhibition-of-hiv-1-replication-in-autologous-cd4-t-cells-indicates-viral-containment-by-multifactorial-mechanisms
#1
Ting Tu, Jianbo Zhan, Danlei Mou, Wei Li, Bin Su, Tong Zhang, Tao Li, Ning Li, Hao Wu, Cong Jin, Huabiao Chen
HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies (NAbs) are present during chronic infection, but the relative contributions of these effector mechanisms to viral containment remain unclear. Here, using an in vitro model involving autologous CD4(+) T cells, primary HIV-1 isolates, HIV-1-specific CTLs, and neutralizing monoclonal antibodies, we show that b12, a potent and broadly neutralizing monoclonal antibody to HIV-1, was able to block viral infection when preincubated with virus prior to infection, but was much less effective than CTLs at limiting virus replication when added to infected cell cultures...
September 15, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28884445/antiviral-activity-of-quercetin-3-%C3%AE-o-d-glucoside-against-zika-virus-infection
#2
LETTER
Gary Wong, Shihua He, Vinayakumar Siragam, Yuhai Bi, Majambu Mbikay, Michel Chretien, Xiangguo Qiu
No abstract text is available yet for this article.
September 5, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28865053/dc-sign-promotes-japanese-encephalitis-virus-transmission-from-dendritic-cells-to-t-cells-via-virological-synapses
#3
Ping Wang, Mei Li, Wei Lu, Di Zhang, Qinxue Hu, Yalan Liu
Skin-resident dendritic cells (DCs) likely encounter incoming viruses in the first place, and their migration to lymph nodes following virus capture may promote viral replication. However, the molecular mechanisms underlying these processes remain unclear. In the present study, we found that compared to cell-free viruses, DC-bound viruses showed enhanced capture of JEV by T cells. Additionally, JEV infection was increased by co-culturing DCs and T cells. Blocking the C-type lectin receptor DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) with neutralizing antibodies or antagonists blocked JEV transmission to T cells...
August 31, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28865052/an-improved-method-for-identifying-sumoylation-sites-of-viral-proteins
#4
LETTER
Yan Liu, Zhongyuan Tan, Bo Shu, Yuan Zhang, Caishang Zheng, Xianliang Ke, Xi Chen, Hanzhong Wang, Zhenhua Zheng
No abstract text is available yet for this article.
August 31, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28840565/interplay-between-hepatitis-c-virus-and-arf4
#5
LETTER
Na Zhang, Youyang Ke, Leiliang Zhang
No abstract text is available yet for this article.
August 18, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28861771/recombinant-rabies-virus-expressing-il-15-enhances-immunogenicity-through-promoting-the-activation-of-dendritic-cells-in-mice
#6
Tiange Chen, Yajing Zhang, Zhao Wang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Zhen F Fu, Ling Zhao, Ming Zhou
Rabies remains a public health threat that kills approximately 59,000 people worldwide each year, most of which are from the developing countries of Africa and Asia where dog rabies are endemic. Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin (IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus (RABV) strain LBNSE (designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28840564/human-leukemia-antigen-a-0201-restricted-epitopes-of-human-endogenous-retrovirus-w-family-envelope-herv-w-env-induce-strong-cytotoxic-t-lymphocyte-responses
#7
Xiaoning Tu, Shan Li, Lijuan Zhao, Ran Xiao, Xiuling Wang, Fan Zhu
Human endogenous retrovirus W family (HERV-W) envelope (env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity. However, there are no reports investigating whether human leukemia antigen (HLA)-A*0201(+) restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. In the present study, HERV-W env-derived epitopes presented by HLA-A*0201 are described with the potential for use in adoptive immunotherapy...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28795354/drug-resistance-mutation-profiles-of-the-drug-na%C3%A3-ve-and-first-line-regimen-treated-hiv-1-infected-population-of-suzhou-china
#8
Tingting Li, Feng Qian, Ting Yuan, Weilu Xu, Li Zhu, Jinlong Huang, Haiyan Wang, Yueping Zhu, Yinling Wang, Xiaohong Li, Saihong Gu, Zhuqing Tan, Hui Chen, Xiangrong Luo, Wei Zhu, Wenjuan Lu, Ping Xu, Ming Li, Yuying Chen, Yong Gao, Rongge Yang, Chuanwu Zhu, Binlian Sun
Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance (TDR) and acquired drug resistance mutation (ADR) profiles, we collected blood specimens from 127 drug-naïve and 117 first-line drug-treated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified pol fragments from 100 drug-naïve and 20 drug-treated samples. We then determined the drug-resistant mutations to protease (PR) and reverse-transcriptase (RT) inhibitors according to the Stanford drug resistance database...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28795353/reconciling-individual-and-population-levels-of-porcine-reproductive-and-respiratory-syndrome-virus-evolution
#9
LETTER
Giovanni Franzo, Claudia Maria Tucciarone, Mattia Cecchinato, Michele Drigo
No abstract text is available yet for this article.
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28755162/coexistence-of-multiple-genotypes-of-porcine-epidemic-diarrhea-virus-with-novel-mutant-s-genes-in-the-hubei-province-of-china-in-2016
#10
Zhe Zeng, Ting-Ting Li, Xin Jin, Fu-Hu Peng, Nian-Hua Song, Gui-Qing Peng, Xing-Yi Ge
The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010. Since then, large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China. However, the molecular diversity and epidemiology of PEDV in different provinces has not been completely understood. To determine the molecular diversity of PEDV in the Hubei Province of China, we collected 172 PED samples from 34 farms across the province in 2016 and performed reverse transcription polymerase chain reaction (RT-PCR) by targeting the nucleocapsid (N) gene...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28744727/host-protein-atlastin-1-promotes-human-immunodeficiency-virus-hiv-1-replication
#11
LETTER
Wenyuan Shen, Bin Liu, Zhou Liu, Jiabin Feng, Chang Liu, Xiaohong Kong
No abstract text is available yet for this article.
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28744726/evaluation-of-purified-recombinant-spike-fragments-for-assessment-of-the-presence-of-serum-neutralizing-antibodies-against-a-variant-strain-of-porcine-epidemic-diarrhea-virus
#12
Jianwei Hao, Yun Zhang, Shengkun Fang, Zhifen Wen, Xiangbin Zhang, Chunyi Xue, Yongchang Cao
Since 2010, variant strains of porcine epidemic diarrhea virus (PEDV) have caused disasters in the pork industry. The spike (S) protein, as the major immunity-eliciting antigen, has previously been used for serological testing and has been found to correlate significantly with the results of the serum neutralization (SN) test. However, further evaluation of this method is needed as new epidemic strains of PEDV emerge. Hence, the main objective of this study was to assess sow sera and determine the correlation between enzyme-linked immunosorbent assay (ELISA) results (involving a newly isolated GDS01 virus-based ELISA and ELISAs based on seven recombinant fragments comprising overlapping S1 and partial S2 sequences) and SN titers...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28721632/detection-and-characterization-of-three-zoonotic-viruses-in-wild-rodents-and-shrews-from-shenzhen-city-china
#13
Bo Wang, Chun-Lin Cai, Bei Li, Wei Zhang, Yan Zhu, Wei-Hong Chen, Fei Zhuo, Zheng-Li Shi, Xing-Lou Yang
Diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential. Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. To determine the distribution of zoonotic viruses in Shenzhen city, the major city in southern China with a high population density, we analyzed 225 rodents (Rattus norvegicus and Rattus flavipectus) and 196 shrews (Suncus murinus) from urban and rural districts for the presence of mammarenavirus, hantavirus, and hepatitis E virus (HEV) by RT-PCR targeting the conserved regions...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28674773/influenza-a-virus-induced-downregulation-of-mir-26a-contributes-to-reduced-ifn%C3%AE-%C3%AE-production
#14
Shijuan Gao, Jiandong Li, Liping Song, Jiaoxiang Wu, Wenlin Huang
Innate immunity provides immediate defense against viral infection. Influenza A virus (IAV) is able to get past the first line of defense. Elucidation of the molecular interaction between influenza factors and the newly recognized host players in the innate response might help in our understanding of the root causes of virulence and pathogenicity of IAV. In this study, we show that expression of miR-26a leads to a significant inhibition of IAV replication. miR-26a does not directly target IAV genome. Instead, miR-26a activates the type I interferon (IFN) signaling pathway and promotes the production of IFN-stimulated genes, thus suppressing viral replication...
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28646484/a-practical-approach-to-generate-suitable-de-novo-synthesis-rna-template-for-a-flavivirus-rna-dependent-rna-polymerase
#15
LETTER
Wei Shi, Peng Gong
No abstract text is available yet for this article.
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28643195/a-convenient-immunochromatographic-test-strip-for-rapid-detection-of-scylla-serrata-reovirus
#16
LETTER
Dongyang Fan, Jingwen Liu, Miaomiao Xu, Yangyang Yuan, Jifang Yang, Jigang Chen
No abstract text is available yet for this article.
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28550493/cypovirus-capsid-protein-vp5-has-nucleoside-triphosphatase-activity
#17
LETTER
Jie Yang, Qi Qian, Teng-Feng Li, Xueli Yang, Sok Jin Won, Xi Zhou
No abstract text is available yet for this article.
August 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28669005/phylogenetic-analysis-based-on-mitochondrial-dna-sequences-of-wild-rats-and-the-relationship-with-seoul-virus-infection-in-hubei-china
#18
Dong-Ying Liu, Jing Liu, Bing-Yu Liu, Yuan-Yuan Liu, Hai-Rong Xiong, Wei Hou, Zhan-Qiu Yang
Seoul virus (SEOV), which is predominantly carried by Rattus norvegicus, is one of the major causes of hemorrhagic fever with renal syndrome (HFRS) in China. Hubei province, located in the central south of China, has experienced some of the most severe epidemics of HFRS. To investigate the mitochondrial DNA (mtDNA)-based phylogenetics of wild rats in Hubei, and the relationship with SEOV infection, 664 wild rats were captured from five trapping sites in Hubei from 2000-2009 and 2014-2015. Using reverse-transcription (RT)-PCR, 41 (6...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28669004/an-update-epstein-barr-virus-and-immune-evasion-via-microrna-regulation
#19
REVIEW
Lielian Zuo, Wenxin Yue, Shujuan Du, Shuyu Xin, Jing Zhang, Lingzhi Liu, Guiyuan Li, Jianhong Lu
Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that microRNAs (miRNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes miRNAs for immune evasion. EBV encodes miRNAs targeting both viral and host genes involved in the immune response...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28656540/human-endogenous-retrovirus-w-env-increases-nitric-oxide-production-and-enhances-the-migration-ability-of-microglia-by-regulating-the-expression-of-inducible-nitric-oxide-synthase
#20
Ran Xiao, Shan Li, Qian Cao, Xiuling Wang, Qiujin Yan, Xiaoning Tu, Ying Zhu, Fan Zhu
Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter-nitric oxide (NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env...
June 2017: Virologica Sinica
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