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Virologica Sinica

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https://www.readbyqxmd.com/read/28303446/expression-of-human-cytomegalovirus-components-in-the-brain-tissues-of-patients-with-rasmussen-s-encephalitis
#1
Yao Zhang, Yisong Wang, Sichang Chen, Shuai Chen, Yuguang Guan, Changqing Liu, Tianfu Li, Guoming Luan, Jing An
Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus (HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters...
March 2, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28255852/avian-influenza-virus-directly-infects-human-natural-killer-cells-and-inhibits-cell-activity
#2
Huawei Mao, Yinping Liu, Sin Fun Sia, J S Malik Peiris, Yu-Lung Lau, Wenwei Tu
Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity...
February 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28224385/evaluation-of-real-time-rt-pcr-assays-for-detection-and-quantification-of-norovirus-genogroups-i-and-ii
#3
Kitwadee Rupprom, Porntip Chavalitshewinkoon-Petmitr, Pornphan Diraphat, Leera Kittigul
Noroviruses are the leading cause of acute gastroenteritis in humans. Real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) is a promising molecular method for the detection of noroviruses. In this study, the performance of three TaqMan real-time RT-PCR assays was assessed, which were one commercially available real-time RT-PCR kit (assay A: Norovirus Real Time RT-PCR kit) and two in-house real-time RT-PCR assays (assay B: LightCycler RNA Master Hybprobe and assay C: RealTime ready RNA Virus Master)...
February 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28190175/lack-of-association-between-integrin-%C3%AE-v%C3%AE-3-gene-polymorphisms-and-hemorrhagic-fever-with-renal-syndrome-in-han-chinese-from-hubei-china
#4
Xiao-Ping Chen, Hai-Rong Xiong, Ni Zhu, Qing-Zhou Chen, Hui Wang, Chao-Jie Zhong, Mei-Rong Wang, Shuang Lu, Fan Luo, Wei Hou
Hantaviruses belong to the family Bunyaviridae and cause hemorrhagic fever with renal syndrome (HFRS) in humans. β3 integrins, including αVβ3 and αIIbβ3 integrins, act as receptors on endothelial cells and play key roles in cellular entry during the pathogenesis of hantaviruses. Previous study demonstrated that the polymorphisms of integrin αIIbβ3 are associated with susceptibility to hantavirus infection and the disease severity of HFRS in Shaanxi Province of China, rather than in Finland. However, the polymorphisms of integrin αvβ3 in patients with HFRS was incompletely understood...
February 9, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28124222/recent-advances-in-the-identification-of-the-host-factors-involved-in-dengue-virus-replication
#5
REVIEW
Yi Wang, Ping Zhang
Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection...
January 24, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120221/hantavirus-infection-a-global-zoonotic-challenge
#6
REVIEW
Hong Jiang, Xuyang Zheng, Limei Wang, Hong Du, Pingzhong Wang, Xuefan Bai
Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide...
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120220/molecular-epidemiology-demonstrates-that-imported-and-local-strains-circulated-during-the-2014-dengue-outbreak-in-guangzhou-china
#7
Geng Li, Pan Pan, Qiuyan He, Xiujuan Kong, Kailang Wu, Wei Zhang, Yuntao Liu, Huiting Huang, Jianbo Liu, Zhongde Zhang, De Wu, Xiaoping Lai, Xiaohong Liu, Jianguo Wu
The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains...
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120219/antigenicity-of-severe-fever-with-thrombocytopenia-syndrome-virus-nucleocapsid-protein-and-its-potential-application-in-the-virus-serodiagnosis
#8
LETTER
Abulimiti Moming, Yujiang Zhang, Chenchen Chang, Huan Yu, Meifang Wang, Zhihong Hu, Fei Deng, Surong Sun
No abstract text is available yet for this article.
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28063012/a-novel-mosquito-borne-reassortant-orbivirus-isolated-from-xishuangbanna-china
#9
LETTER
Shaozhen Xing, Xiaofang Guo, Xianglilan Zhang, Qiumin Zhao, Lingli Li, Shuqing Zuo, Xiaoping An, Guangqian Pei, Qiang Sun, Shi Cheng, Yunfei Wang, Hang Fan, Zhiqiang Mi, Yong Huang, Zhiyi Zhang, Hongning Zhou, Jiusong Zhang, Yigang Tong
No abstract text is available yet for this article.
December 30, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28251518/from-the-new-editor-in-chief
#10
EDITORIAL
Zheng-Li Shi
No abstract text is available yet for this article.
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251517/a-new-strain-of-crimean-congo-hemorrhagic-fever-virus-isolated-from-xinjiang-china
#11
Rong Guo, Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Dan Liu, Jinliang Liu, Juan Yang, Qiguo Wang, Zhihong Hu, Yujiang Zhang, Fei Deng
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251516/isolation-characterization-and-phylogenic-analysis-of-three-new-severe-fever-with-thrombocytopenia-syndrome-bunyavirus-strains-derived-from-hubei-province-china
#12
Yanfang Zhang, Shu Shen, Junming Shi, Zhengyuan Su, Mingyue Li, Wenjing Zhang, Mengmeng Li, Zhihong Hu, Cheng Peng, Xin Zheng, Fei Deng
Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251515/current-status-of-severe-fever-with-thrombocytopenia-syndrome-in-china
#13
REVIEW
Jianbo Zhan, Qin Wang, Jing Cheng, Bing Hu, Jing Li, Faxian Zhan, Yi Song, Deyin Guo
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity, clinical features, and diagnostics of SFTSV in China...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/27995422/entry-of-severe-fever-with-thrombocytopenia-syndrome-virus
#14
REVIEW
Fei Yuan, Aihua Zheng
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses...
December 16, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063014/roles-of-i%C3%AE%C2%BAb-kinase-%C3%AE%C2%B5-in-the-innate-immune-defense-and-beyond
#15
REVIEW
Junjie Zhang, Mao Tian, Zanxian Xia, Pinghui Feng
IκB kinase ε (IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKε in interferon (IFN) signaling. In addition to its roles in innate immunity, recent studies also demonstrate that IKKε is a key regulator of the adaptive immune response. Specifically, IKKε functions as a negative feedback kinase to curtail CD8 T cell response, implying that it can be a potential therapeutic target to boost antiviral and antitumor T cell immunity...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063013/the-role-of-micrornas-in-hepatocyte-metabolism-and-hepatitis-b-virus-replication
#16
REVIEW
Wanyu Deng, Mengji Lu
Though efficient vaccines against hepatitis B virus (HBV) and antiviral therapies are available, chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28000060/a-new-strategy-for-full-length-ebola-virus-glycoprotein-expression-in-e-coli
#17
Junjie Zai, Yinhua Yi, Han Xia, Bo Zhang, Zhiming Yuan
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression of full-length GP in Escherichia coli hinders the further study of its function in viral pathogenesis. In this study, the vp40 gene was fused to the full-length gp gene and cloned into a prokaryotic expression vector...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27995421/characterization-of-two-monoclonal-antibodies-38f10-and-44d11-against-the-major-envelope-fusion-protein-of-helicoverpa-armigera-nucleopolyhedrovirus
#18
Zijiao Zou, Jinliang Liu, Zhiying Wang, Fei Deng, Hualin Wang, Zhihong Hu, Manli Wang, Tao Zhang
The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor (F0) and then cleaved into a disulfide-linked F1 and F2 subunits during the process of protein maturation and secretion. To facilitate further investigation into the structure and function of F protein during virus infection, monoclonal antibodies (mAbs) against the F2 subunit of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (HaF) were generated...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933565/kshv-strategies-for-host-dsdna-sensing-machinery
#19
REVIEW
Hang Gao, Yanyan Song, Chengrong Liu, Qiming Liang
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933564/an-improved-reverse-genetics-system-for-newcastle-disease-virus-genotype-vii
#20
LETTER
Yuzhang Sun, Mingjun Sun, Yonglian Dai, Renfu Yin, Zhuang Ding
No abstract text is available yet for this article.
December 2016: Virologica Sinica
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