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Virologica Sinica

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https://www.readbyqxmd.com/read/28429274/retromer-localizes-to-autophagosomes-during-hcv-replication
#1
LETTER
Peiqi Yin, Zhi Hong, Leiliang Zhang, Youyang Ke
No abstract text is available yet for this article.
April 13, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28421419/phylogenetic-analysis-of-avian-infectious-bronchitis-virus-isolates-from-morocco-a-retrospective-study-1983-to-2014
#2
LETTER
Siham Fellahi, Mehdi El Harrak, Slimane Khayi, Jean-Luc Guerin, Jens H Kuhn, Mohammed El Houadfi, My Mustapha Ennaji, Mariette Ducatez
No abstract text is available yet for this article.
April 12, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28393313/molecular-detection-of-viruses-in-kenyan-bats-and-discovery-of-novel-astroviruses-caliciviruses-and-rotaviruses
#3
Cecilia Waruhiu, Sheila Ommeh, Vincent Obanda, Bernard Agwanda, Francis Gakuya, Xing-Yi Ge, Xing-Lou Yang, Li-Jun Wu, Ali Zohaib, Ben Hu, Zheng-Li Shi
This is the first country-wide surveillance of bat-borne viruses in Kenya spanning from 2012-2015 covering sites perceived to have medium to high level bat-human interaction. The objective of this surveillance study was to apply a non-invasive approach using fresh feces to detect viruses circulating within the diverse species of Kenyan bats. We screened for both DNA and RNA viruses; specifically, astroviruses (AstVs), adenoviruses (ADVs), caliciviruses (CalVs), coronaviruses (CoVs), flaviviruses, filoviruses, paramyxoviruses (PMVs), polyomaviruses (PYVs) and rotaviruses...
April 6, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28389993/human-rhinovirus-c-infection-is-associated-with-asthma-in-children-determined-by-xtag-respiratory-viral-panel-fast
#4
LETTER
Dongmei Chen, Qinwei Song, Runan Zhu, Yuan Qian, Yu Sun, Jie Deng, Fang Wang, Yaxin Ding, Run Tian, Chuanhe Liu, Wenjing Zhu, Linqing Zhao
No abstract text is available yet for this article.
April 6, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28382574/genome-analysis-of-heliothis-virescens-ascovirus-3h-isolated-from-china
#5
Guo-Hua Huang, Dian-Hai Hou, Manli Wang, Xiao-Wen Cheng, Zhihong Hu
No ascovirus isolated from China has been sequenced so far. Therefore, in this study, we aimed to sequence the genome of Heliothis virescens ascovirus 3h (HvAV-3h) using the 454 pyrosequencing technology. The genome was found to be 190,519-bp long with a G+C content of 45.5%. We also found that it encodes 185 hypothetical open reading frames (ORFs) along with at least 50 amino acids, including 181 ORFs found in other ascoviruses and 4 unique ORFs. Gene-parity plots and phylogenetic analysis revealed a close relationship between HvAV-3h and three other HvAV-3a strains and a distant relationship with Spodoptera frugiperda ascovirus 1a (SfAV-1a), Trichoplusia ni ascovirus 6a (TnAV-6a), and Diadromus pulchellus ascovirus 4a (DpAV-4a)...
March 30, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28353186/a-novel-phenotypic-assay-of-hepatitis-b-virus-polymerase-with-extensive-site-specific-mutagenesis
#6
LETTER
Ya Liu, Ying-Ying Luo, Xue-Fei Cai, Quan-Xin Long, Chun-Yang Gan, Liu-Qing Yang, Haitao Guo, Ai-Long Huang, Wen-Lu Zhang, Jie-Li Hu
No abstract text is available yet for this article.
March 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28303446/expression-of-human-cytomegalovirus-components-in-the-brain-tissues-of-patients-with-rasmussen-s-encephalitis
#7
Yao Zhang, Yisong Wang, Sichang Chen, Shuai Chen, Yuguang Guan, Changqing Liu, Tianfu Li, Guoming Luan, Jing An
Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus (HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters...
March 2, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28255852/avian-influenza-virus-directly-infects-human-natural-killer-cells-and-inhibits-cell-activity
#8
Huawei Mao, Yinping Liu, Sin Fun Sia, J S Malik Peiris, Yu-Lung Lau, Wenwei Tu
Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity...
February 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28224385/evaluation-of-real-time-rt-pcr-assays-for-detection-and-quantification-of-norovirus-genogroups-i-and-ii
#9
Kitwadee Rupprom, Porntip Chavalitshewinkoon-Petmitr, Pornphan Diraphat, Leera Kittigul
Noroviruses are the leading cause of acute gastroenteritis in humans. Real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) is a promising molecular method for the detection of noroviruses. In this study, the performance of three TaqMan real-time RT-PCR assays was assessed, which were one commercially available real-time RT-PCR kit (assay A: Norovirus Real Time RT-PCR kit) and two in-house real-time RT-PCR assays (assay B: LightCycler RNA Master Hybprobe and assay C: RealTime ready RNA Virus Master)...
February 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251518/from-the-new-editor-in-chief
#10
EDITORIAL
Zheng-Li Shi
No abstract text is available yet for this article.
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251517/a-new-strain-of-crimean-congo-hemorrhagic-fever-virus-isolated-from-xinjiang-china
#11
Rong Guo, Shu Shen, Yanfang Zhang, Junming Shi, Zhengyuan Su, Dan Liu, Jinliang Liu, Juan Yang, Qiguo Wang, Zhihong Hu, Yujiang Zhang, Fei Deng
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world. Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China. Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251516/isolation-characterization-and-phylogenic-analysis-of-three-new-severe-fever-with-thrombocytopenia-syndrome-bunyavirus-strains-derived-from-hubei-province-china
#12
Yanfang Zhang, Shu Shen, Junming Shi, Zhengyuan Su, Mingyue Li, Wenjing Zhang, Mengmeng Li, Zhihong Hu, Cheng Peng, Xin Zheng, Fei Deng
Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28251515/current-status-of-severe-fever-with-thrombocytopenia-syndrome-in-china
#13
REVIEW
Jianbo Zhan, Qin Wang, Jing Cheng, Bing Hu, Jing Li, Faxian Zhan, Yi Song, Deyin Guo
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV). SFTSV is associated with a high mortality rate and has been reported in China, South Korea and Japan. SFTSV undergoes rapid changes owing to evolution, gene mutations, and reassortment between different strains of SFTSV. In this review, we summarize the recent cases and general properties of SFTS, focusing on the epidemiology, genetic diversity, clinical features, and diagnostics of SFTSV in China...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28190175/lack-of-association-between-integrin-%C3%AE-v%C3%AE-3-gene-polymorphisms-and-hemorrhagic-fever-with-renal-syndrome-in-han-chinese-from-hubei-china
#14
Xiao-Ping Chen, Hai-Rong Xiong, Ni Zhu, Qing-Zhou Chen, Hui Wang, Chao-Jie Zhong, Mei-Rong Wang, Shuang Lu, Fan Luo, Wei Hou
Hantaviruses belong to the family Bunyaviridae and cause hemorrhagic fever with renal syndrome (HFRS) in humans. β3 integrins, including αVβ3 and αIIbβ3 integrins, act as receptors on endothelial cells and play key roles in cellular entry during the pathogenesis of hantaviruses. Previous study demonstrated that the polymorphisms of integrin αIIbβ3 are associated with susceptibility to hantavirus infection and the disease severity of HFRS in Shaanxi Province of China, rather than in Finland. However, the polymorphisms of integrin αvβ3 in patients with HFRS was incompletely understood...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28124222/recent-advances-in-the-identification-of-the-host-factors-involved-in-dengue-virus-replication
#15
REVIEW
Yi Wang, Ping Zhang
Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120221/hantavirus-infection-a-global-zoonotic-challenge
#16
REVIEW
Hong Jiang, Xuyang Zheng, Limei Wang, Hong Du, Pingzhong Wang, Xuefan Bai
Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120220/molecular-epidemiology-demonstrates-that-imported-and-local-strains-circulated-during-the-2014-dengue-outbreak-in-guangzhou-china
#17
Geng Li, Pan Pan, Qiuyan He, Xiujuan Kong, Kailang Wu, Wei Zhang, Yuntao Liu, Huiting Huang, Jianbo Liu, Zhongde Zhang, De Wu, Xiaoping Lai, Xiaohong Liu, Jianguo Wu
The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/27995422/entry-of-severe-fever-with-thrombocytopenia-syndrome-virus
#18
REVIEW
Fei Yuan, Aihua Zheng
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/27853993/the-roles-of-ebolavirus-glycoproteins-in-viral-pathogenesis
#19
REVIEW
Yun-Jia Ning, Fei Deng, Zhihong Hu, Hualin Wang
Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics...
February 2017: Virologica Sinica
https://www.readbyqxmd.com/read/27853992/progress-towards-understanding-the-pathogenesis-of-dengue-hemorrhagic-fever
#20
REVIEW
Xiaojing Pang, Rudian Zhang, Gong Cheng
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses...
February 2017: Virologica Sinica
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