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Virologica Sinica

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https://www.readbyqxmd.com/read/30397896/an-assessment-of-amplicon-sequencing-based-method-for-viral-intrahost-analysis
#1
LETTER
Ming Ni, Chen Chen, Di Liu
No abstract text is available yet for this article.
November 5, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30374827/detection-of-ebv-and-hhv6-in-the-brain-tissue-of-patients-with-rasmussen-s-encephalitis
#2
Dong Liu, Xin Wang, Yisong Wang, Peigang Wang, Dongying Fan, Sichang Chen, Yuguang Guan, Tianfu Li, Jing An, Guoming Luan
Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry. In the RE group, EBV and HHV6 antigens were detected in 56.7% (17/30) and 50% (15/30) of individuals, respectively...
October 29, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30374826/significant-spike-specific-igg-and-neutralizing-antibodies-in-mice-induced-by-a-novel-chimeric-virus-like-particle-vaccine-candidate-for-middle-east-respiratory-syndrome-coronavirus
#3
LETTER
Jiaming Lan, Yao Deng, Jingdong Song, Baoying Huang, Wenling Wang, Wenjie Tan
No abstract text is available yet for this article.
October 29, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30374825/targeting-ciaps-a-new-option-for-functional-cure-of-chronic-hepatitis-b-infection
#4
Hongyan Liu, Jinlin Hou, Xiaoyong Zhang
No abstract text is available yet for this article.
October 29, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30353316/professor-hu-zhihong-the-new-president-of-the-society-for-invertebrate-pathology
#5
EDITORIAL
Basil Arif, Jiali Si, Zheng-Li Shi
No abstract text is available yet for this article.
October 23, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30353315/identification-of-nonstructural-protein-8-as-the-n-terminus-of-the-rna-dependent-rna-polymerase-of-porcine-reproductive-and-respiratory-syndrome-virus
#6
Yuanyuan Liu, Yunhao Hu, Yue Chai, Liping Liu, Jiangwei Song, Shaochuan Zhou, Jia Su, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member within the family Arteriviridae of the order Nidovirales. Replication of this positive-stranded RNA virus within the host cell involves expression of viral replicase proteins encoded by two ORFs, namely ORF1a and ORF1b. In particular, translation of ORF1b depends on a -1-ribosomal frameshift strategy. Thus, nonstructural protein 9 (nsp9), the first protein within ORF1b that specifies the function of the viral RNA-dependent RNA polymerase, is expressed as the C-terminal extension of nsp8, a small nsp that is encoded by ORF1a...
October 23, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30328580/histone-deacetylase-3-inhibitor-suppresses-hepatitis-c-virus-replication-by-regulating-apo-a1-and-leap-1-expression
#7
Yuan Zhou, Qian Wang, Qi Yang, Jielin Tang, Chonghui Xu, Dongwei Gai, Xinwen Chen, Jizheng Chen
Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobial peptide 1(LEAP-1) and downregulation of apolipoprotein-A1 (Apo-A1), as determined by microarray and quantitative RT-PCR analyses...
October 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30328579/characterization-of-avian-like-influenza-a-h4n6-virus-isolated-from-caspian-seal-in-2012
#8
LETTER
Marina Gulyaeva, Ivan Sobolev, Kirill Sharshov, Olga Kurskaya, Alexander Alekseev, Lidia Shestopalova, Anna Kovner, Yuhai Bi, Weifeng Shi, Michael Shchelkanov, Alexander Shestopalov
No abstract text is available yet for this article.
October 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30328013/cypa-regulates-aip4-mediated-m1-ubiquitination-of-influenza-a-virus
#9
Madina Mahesutihan, Weinan Zheng, Liang Cui, Yun Li, Pengtao Jiao, Wenxian Yang, Wei Liu, Jing Li, Wenhui Fan, Limin Yang, Wenjun Liu, Lei Sun
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin-proteasome-mediated degradation of M1. However, the mechanism by which CypA regulates M1 ubiquitination remains unknown. In this study, we reported that E3 ubiquitin ligase AIP4 promoted K48-linked ubiquitination of M1 at K102 and K104, and accelerated ubiquitin-proteasome-mediated degradation of M1. The recombinant IAV with mutant M1 (K102R/K104R) could not be rescued, suggesting that the ubiquitination of M1 at K102/K104 was essential for IAV replication...
October 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30328012/the-distribution-of-different-clades-of-seneca-valley-viruses-in-guangdong-province-china
#10
Pan Chen, Fan Yang, Weijun Cao, Huanan Liu, Keshan Zhang, Xiangtao Liu, Zhiwen Xu, Zixiang Zhu, Haixue Zheng
Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in significant economic losses to the swine industry. The first identification of SVV in China was reported in Guangdong Province, a major swine producing province. The cases of SVV were continuously reported in Guangdong in 2015 and 2016...
October 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30311101/phylogeography-transmission-and-viral-proteins-of-nipah-virus
#11
REVIEW
Bangyao Sun, Lijia Jia, Bilin Liang, Quanjiao Chen, Di Liu
Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has become a great threat to domestic animals and humans. Sporadic outbreaks and person-to-person transmission over the past two decades have resulted in hundreds of human fatalities. Epidemiological surveys have shown that NiV is distributed in Asia, Africa, and the South Pacific Ocean, and is transmitted by its natural reservoir, Pteropid bats...
October 11, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30311100/countrywide-survey-for-mers-coronavirus-antibodies-in-dromedaries-and-humans-in-pakistan
#12
Ali Zohaib, Muhammad Saqib, Muhammad Ammar Athar, Jing Chen, Awais-Ur-Rahman Sial, Saeed Khan, Zeeshan Taj, Halima Sadia, Usman Tahir, Muhammad Haleem Tayyab, Muhammad Asif Qureshi, Muhammad Khalid Mansoor, Muhammad Ahsan Naeem, Bing-Jie Hu, Bilal Ahmed Khan, Ikram Din Ujjan, Bei Li, Wei Zhang, Yun Luo, Yan Zhu, Cecilia Waruhiu, Iahtasham Khan, Xing-Lou Yang, Muhammad Sohail Sajid, Victor Max Corman, Bing Yan, Zheng-Li Shi
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 776) and serum (n = 1050) samples were collected from camels between November 2015 and February 2018. Samples were collected from animal markets, free-roaming herds and abattoirs. An in-house ELISA was developed to detect IgG against MERS-CoV...
October 11, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30225586/common-infections-may-lead-to-alzheimer-s-disease
#13
Yuyan Wang, Ling Ding, Qing Zhu, Minfeng Shu, Qiliang Cai
No abstract text is available yet for this article.
September 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30155853/genome-characteristics-of-the-cyclophragma-undans-nucleopolyhedrovirus-a-distinct-species-in-group-i-of-alphabaculovirus
#14
Zheng Zhu, Jun Wang, Qianran Wang, Feifei Yin, Xiaoping Liu, Dianhai Hou, Lei Zhang, Haizhou Liu, Jiang Li, Basil M Arif, Hualin Wang, Fei Deng, Zhihong Hu, Manli Wang
The Cyclophragma undans nucleopolyhedrovirus (CyunNPV), a potential pest control agent, was isolated from Cyclophragma undans (Lepidoptera: Lasiocampidae), an important forest pest. In the present study, we performed detailed genome analysis of CyunNPV and compared its genome to those of other Group I alphabaculoviruses. Sequencing of the CyunNPV genome using the Roche 454 sequencing system generated 142,900 bp with a G + C content of 45%. Genome analysis predicted a total of 147 hypothetical open reading frames comprising 38 baculoviral core genes, 24 lepidopteran baculovirus conserved genes, nine Group I Alphabaculovirus conserved genes, 71 common genes, and five genes that are unique to CyunNPV...
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30155852/serological-cross-reactivity-between-zika-and-dengue-viruses-in-experimentally-infected-monkeys
#15
LETTER
Shailendra Mani, Chee Wah Tan, Lin-Fa Wang, Danielle E Anderson
No abstract text is available yet for this article.
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30069823/tandem-3-utr-patterns-and-gene-expression-profiles-of-marc-145-cells-during-prrsv-infection
#16
Ying Wei, Jie Li, Yun Zhang, Chunyi Xue, Yongchang Cao
Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the global pig industry. Alternative polyadenylation (APA) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. However, it is unclear whether APA plays a role in the course of PRRSV infection. To address this issue, in this study we carried out a whole-genome transcriptome analysis of PRRSV-infected Marc-145 African green monkey kidney cells and identified 185 APA switching genes and 393 differentially expressed genes (DEGs)...
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30066045/serological-investigation-of-laboratory-confirmed-and-suspected-ebola-virus-disease-patients-during-the-late-phase-of-the-ebola-outbreak-in-sierra-leone
#17
Yang Liu, YuLan Sun, Wei Wu, AQian Li, XianDa Yang, Shuo Zhang, Chuan Li, QiuDong Su, ShaoJian Cai, DaPeng Sun, HaiYang Hu, Zhe Zhang, XiuXu Yang, Idrissa Kamara, Sheku Koroma, Gerald Bangura, Alie Tia, Abdul Kamara, Matt Lebby, Brima Kargbo, Jiandong Li, Shiwen Wang, XiaoPing Dong, YueLong Shu, WenBo Xu, George F Gao, GuiZhen Wu, DeXin Li, William J Liu, MiFang Liang
This study aimed to investigate the serological characteristics of Ebola virus (EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease (EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction (RT-PCR) for viral RNA and enzyme-linked immunosorbent assay (ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015...
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30062589/molecular-genetic-characterization-of-human-rotavirus-a-strains-circulating-in-moscow-russia-2009-2014
#18
Victoria Kiseleva, Evgeny Faizuloev, Elena Meskina, Anna Marova, Alexey Oksanich, Tatiana Samartseva, Georgy Bakhtoyarov, Natalia Bochkareva, Nikolay Filatov, Andrey Linok, Yulia Ammour, Vitaly Zverev
Enteric viruses are the most common cause of acute gastroenteritis (AGE) in young children and a significant public health problem globally. Hospital admissions of children under 5 years of age with diarrhea are primarily associated with group A rotavirus (RVA) infection. In this retrospective study, the population structure of viruses linked to AGE etiology in young children hospitalized with AGE in Moscow was evaluated, and molecular characterization of RVA strains was performed. Fecal specimens were collected from children under 5 years old hospitalized with AGE between 2009 and 2014 in Moscow, Russia...
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30046995/insights-into-the-temporal-gene-expression-pattern-in-lymantria-dispar-larvae-during-the-baculovirus-induced-hyperactive-stage
#19
Upendra Raj Bhattarai, Mandira Katuwal Bhattarai, Fengjiao Li, Dun Wang
Baculoviruses are effective biological control agents for many insect pests. They not only efficiently challenge the host immune system but also make them hyperactive for better virus dispersal. Some investigations have focused on the viral mechanisms for induction of such altered response from the host. However, there are no current studies monitoring changes in gene expression during this altered phenotype in infected larvae. The L. dispar multiple nucleopolyhedrovirus (LdMNPV) induces hyperactivity in third instar L...
August 2018: Virologica Sinica
https://www.readbyqxmd.com/read/30039498/kir2dl2-c1-is-a-risk-factor-for-chronic-infection-and-associated-with-non-response-to-peg-ifn-and-rbv-combination-therapy-in-hepatitis-c-virus-genotype-1b-patients-in-china
#20
LETTER
Song Hu, Fahu Yuan, Lingyan Feng, Fang Zheng, Feili Gong, Hanju Huang, Binlian Sun
No abstract text is available yet for this article.
August 2018: Virologica Sinica
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