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Virologica Sinica

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https://www.readbyqxmd.com/read/28224385/evaluation-of-real-time-rt-pcr-assays-for-detection-and-quantification-of-norovirus-genogroups-i-and-ii
#1
Kitwadee Rupprom, Porntip Chavalitshewinkoon-Petmitr, Pornphan Diraphat, Leera Kittigul
Noroviruses are the leading cause of acute gastroenteritis in humans. Real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) is a promising molecular method for the detection of noroviruses. In this study, the performance of three TaqMan real-time RT-PCR assays was assessed, which were one commercially available real-time RT-PCR kit (assay A: Norovirus Real Time RT-PCR kit) and two in-house real-time RT-PCR assays (assay B: LightCycler RNA Master Hybprobe and assay C: RealTime ready RNA Virus Master)...
February 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28190175/lack-of-association-between-integrin-%C3%AE-v%C3%AE-3-gene-polymorphisms-and-hemorrhagic-fever-with-renal-syndrome-in-han-chinese-from-hubei-china
#2
Xiao-Ping Chen, Hai-Rong Xiong, Ni Zhu, Qing-Zhou Chen, Hui Wang, Chao-Jie Zhong, Mei-Rong Wang, Shuang Lu, Fan Luo, Wei Hou
Hantaviruses belong to the family Bunyaviridae and cause hemorrhagic fever with renal syndrome (HFRS) in humans. β3 integrins, including αVβ3 and αIIbβ3 integrins, act as receptors on endothelial cells and play key roles in cellular entry during the pathogenesis of hantaviruses. Previous study demonstrated that the polymorphisms of integrin αIIbβ3 are associated with susceptibility to hantavirus infection and the disease severity of HFRS in Shaanxi Province of China, rather than in Finland. However, the polymorphisms of integrin αvβ3 in patients with HFRS was incompletely understood...
February 9, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28124222/recent-advances-in-the-identification-of-the-host-factors-involved-in-dengue-virus-replication
#3
REVIEW
Yi Wang, Ping Zhang
Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection...
January 24, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120221/hantavirus-infection-a-global-zoonotic-challenge
#4
REVIEW
Hong Jiang, Xuyang Zheng, Limei Wang, Hong Du, Pingzhong Wang, Xuefan Bai
Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide...
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120220/molecular-epidemiology-demonstrates-that-imported-and-local-strains-circulated-during-the-2014-dengue-outbreak-in-guangzhou-china
#5
Geng Li, Pan Pan, Qiuyan He, Xiujuan Kong, Kailang Wu, Wei Zhang, Yuntao Liu, Huiting Huang, Jianbo Liu, Zhongde Zhang, De Wu, Xiaoping Lai, Xiaohong Liu, Jianguo Wu
The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains...
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28120219/antigenicity-of-severe-fever-with-thrombocytopenia-syndrome-virus-nucleocapsid-protein-and-its-potential-application-in-the-virus-serodiagnosis
#6
LETTER
Abulimiti Moming, Yujiang Zhang, Chenchen Chang, Huan Yu, Meifang Wang, Zhihong Hu, Fei Deng, Surong Sun
No abstract text is available yet for this article.
January 23, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28063012/a-novel-mosquito-borne-reassortant-orbivirus-isolated-from-xishuangbanna-china
#7
LETTER
Shaozhen Xing, Xiaofang Guo, Xianglilan Zhang, Qiumin Zhao, Lingli Li, Shuqing Zuo, Xiaoping An, Guangqian Pei, Qiang Sun, Shi Cheng, Yunfei Wang, Hang Fan, Zhiqiang Mi, Yong Huang, Zhiyi Zhang, Hongning Zhou, Jiusong Zhang, Yigang Tong
No abstract text is available yet for this article.
December 30, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27995422/entry-of-severe-fever-with-thrombocytopenia-syndrome-virus
#8
REVIEW
Fei Yuan, Aihua Zheng
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses...
December 16, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063014/roles-of-i%C3%AE%C2%BAb-kinase-%C3%AE%C2%B5-in-the-innate-immune-defense-and-beyond
#9
REVIEW
Junjie Zhang, Mao Tian, Zanxian Xia, Pinghui Feng
IκB kinase ε (IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKε in interferon (IFN) signaling. In addition to its roles in innate immunity, recent studies also demonstrate that IKKε is a key regulator of the adaptive immune response. Specifically, IKKε functions as a negative feedback kinase to curtail CD8 T cell response, implying that it can be a potential therapeutic target to boost antiviral and antitumor T cell immunity...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063013/the-role-of-micrornas-in-hepatocyte-metabolism-and-hepatitis-b-virus-replication
#10
REVIEW
Wanyu Deng, Mengji Lu
Though efficient vaccines against hepatitis B virus (HBV) and antiviral therapies are available, chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28000060/a-new-strategy-for-full-length-ebola-virus-glycoprotein-expression-in-e-coli
#11
Junjie Zai, Yinhua Yi, Han Xia, Bo Zhang, Zhiming Yuan
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression of full-length GP in Escherichia coli hinders the further study of its function in viral pathogenesis. In this study, the vp40 gene was fused to the full-length gp gene and cloned into a prokaryotic expression vector...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27995421/characterization-of-two-monoclonal-antibodies-38f10-and-44d11-against-the-major-envelope-fusion-protein-of-helicoverpa-armigera-nucleopolyhedrovirus
#12
Zijiao Zou, Jinliang Liu, Zhiying Wang, Fei Deng, Hualin Wang, Zhihong Hu, Manli Wang, Tao Zhang
The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor (F0) and then cleaved into a disulfide-linked F1 and F2 subunits during the process of protein maturation and secretion. To facilitate further investigation into the structure and function of F protein during virus infection, monoclonal antibodies (mAbs) against the F2 subunit of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (HaF) were generated...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933565/kshv-strategies-for-host-dsdna-sensing-machinery
#13
REVIEW
Hang Gao, Yanyan Song, Chengrong Liu, Qiming Liang
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933564/an-improved-reverse-genetics-system-for-newcastle-disease-virus-genotype-vii
#14
LETTER
Yuzhang Sun, Mingjun Sun, Yonglian Dai, Renfu Yin, Zhuang Ding
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27909863/distribution-and-molecular-variability-of-four-tobacco-viruses-in-china
#15
LETTER
Kuan Wu, Wei Chen, Zhaopeng Luo, Bing Wang, Julong Cheng, Zhensheng Kang
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900558/the-role-of-viral-protein-ac34-in-nuclear-relocation-of-subunits-of-the-actin-related-protein-2-3-complex
#16
Jingfang Mu, Yongli Zhang, Yangyang Hu, Xue Hu, Yuan Zhou, Xinwen Chen, Yun Wang
The actin nucleator actin-related protein complex (Arp2/3) is composed of seven subunits: Arp2, Arp3, p40/ARPC1 (P40), p34/ARPC2 (P34), p21/ARPC3 (P21), p20/ARPC4 (P20), and p16/ARPC5 (P16). Arp2/3 plays crucial roles in a variety of cellular activities through regulation of actin polymerization. Autographa californica multiple nucleopolyhedrovirus (AcMNPV), one of the beststudied alphabaculoviruses, induces Arp2/3 nuclear relocation and mediates nuclear actin polymerization to assist in virus replication. We have demonstrated that Ac34, a viral late-gene product, induces translocation of the P40 subunit of Arp2/3 to the nucleus during AcMNPV infection...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900557/primary-ebv-infection-and-hypersensitivity-to-mosquito-bites-a-case-report
#17
LETTER
Ioannis Kyriakidis, Eleni Vasileiou, Sofia Karastrati, Athanasios Tragiannidis, Nikolaos Gompakis, Maria Hatzistilianou
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853991/detection-and-pathogenesis-of-a-novel-swine-h3n2-influenza-virus-containing-three-genes-from-the-2009-pandemic-h1n1-influenza-viruses-in-korea-in-2015
#18
LETTER
Tran Bac Le, In Hong Lee, Byung Jun Kim, Hyun Soo Kim, Sang Heui Seo
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27838882/amino-acids-essential-for-the-interaction-between-cellular-heat-shock-protein-90-and-a-kaposi-s-sarcoma-associated-herpesvirus-encoded-protein-kinase-orf36
#19
LETTER
Chao Wang, Jingchao Wang, Wei Guo, Cong Long, Huan Wang, Xiaoping Sun
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853993/the-roles-of-ebolavirus-glycoproteins-in-viral-pathogenesis
#20
REVIEW
Yun-Jia Ning, Fei Deng, Zhihong Hu, Hualin Wang
Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics...
November 14, 2016: Virologica Sinica
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