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Virologica Sinica

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https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#1
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29767404/carrier-cells-for-delivery-of-oncolytic-measles-virus-into-tumors-determinants-of-efficient-loading
#2
Chun Xu, Mao Xia, Gang Meng, Chunyan Li, Aiqin Jiang, Jiwu Wei
Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge, specific types of cells have been used as carriers for OMV. Differential loading strategies appear to result in different therapeutic outcomes; despite this, only few studies have reported practical ex vivo loading strategies required for effective treatment...
May 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29761267/porcine-fc%C3%AE%C2%B5ri-mediates-porcine-reproductive-and-respiratory-syndrome-virus-multiplication-and-regulates-the-inflammatory-reaction
#3
Peidian Shi, Lilin Zhang, Jiashun Wang, Dong Lu, Yi Li, Jie Ren, Menglu Shen, Lei Zhang, Jinhai Huang
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study, the expression of different Fc receptors (FcRs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of FcγII and FcεRI was significantly up-regulated under PRRSV-antibody complex infection...
May 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29737506/hiv-1-protein-tat-1-72-impairs-neuronal-dendrites-via-activation-of-pp1-and-regulation-of-the-creb-bdnf-pathway
#4
Yu Liu, Deyu Zhou, Jiabin Feng, Zhou Liu, Yue Hu, Chang Liu, Xiaohong Kong
Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the health-related quality of their lives. Although neurons cannot be infected by HIV-1, shed viral proteins such as transactivator of transcription (Tat) can cause dendritic damage. However, the detailed molecular mechanism of Tat-induced neuronal impairment remains unknown. In this study, we first showed that recombinant Tat (1-72 aa) induced neurotoxicity in primary cultured mouse neurons...
May 8, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29675605/histopathological-features-and-viral-antigen-distribution-in-the-lung-of-fatal-patients-with-enterovirus-71-infection
#5
LETTER
Zhenli Liang, Hongbo Pan, Xijing Wang, Yinchuan Zhu, Yiwu Dang, Xiaohui Fan, Lingxi Gao, Zengfeng Zhang
No abstract text is available yet for this article.
April 19, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29654554/evaluation-of-epstein-barr-virus-salivary-shedding-in-hiv-aids-patients-and-haart-use-a-retrospective-cohort-study
#6
Yan Yan, Yong Ren, Renfang Chen, Jing Hu, Yongjia Ji, Junyang Yang, Jiayin Shen, Lvyin Hu, Hao Pei, Jun Wang, Yuanwang Qiu, Hongzhou Lu, Lihua Huang
Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus (EBV) in saliva and relationship with highly active antiretroviral therapy (HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in Wuxi and Shanghai, China from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction...
April 13, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29633082/monoclonal-antibody-based-serological-detection-methods-for-wheat-dwarf-virus
#7
Minghao Zhang, Rui Chen, Xueping Zhou, Jianxiang Wu
Wheat dwarf disease caused by wheat dwarf virus (WDV) is currently present in wheat growing regions in China and causes serious losses in wheat yield. To develop reliable and effective serological detection methods for WDV, the coat protein (CP) gene of WDV was cloned and expressed in Escherichia coli. The purified recombinant CP protein was immunized to BALB/c mice, and four hybridoma cell lines (i.e. 18G10, 9G4, 23F4 and 22A10) secreting anti-WDV monoclonal antibodies (MAbs) were obtained through the hybridoma technique...
April 9, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29616412/a-duplex-real-time-pcr-assay-for-the-simultaneous-detection-of-porcine-circovirus-2-and-circovirus-3
#8
Xiangdong Li, Mingming Qiao, Ming Sun, Kegong Tian
Porcine circoviruses (PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-infections in clinical samples. Thus, it would be practical to develop a duplex PCR method to detect PCV2 and PCV3 simultaneously. In this study, specific primers and probes were designed to target PCV2 cap and PCV3 rep genes. A duplex real-time PCR method was then developed to detect the two viruses...
April 3, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29594909/an-attenuated-highly-pathogenic-chinese-prrs-viral-vaccine-confers-cross-protection-to-pigs-against-challenge-with-the-emerging-prrsv-nadc30-like-strain
#9
Hewei Zhang, Mingqi Xia, Wei Wang, Decai Ju, Long Cao, Bai Wu, Xin Wang, Ying Wu, Ni Song, Jiaxin Hu, Changxiao Tian, Shucheng Zhang, Hua Wu
A novel PRRSV strain was isolated in China that was genetically similar to the NADC30 strain which is reported to have spread throughout China. The objective of the present study was to evaluate the cross-protective efficacy of the live vaccine TJM-F92 in young pigs against challenge with a NADC30-like strain, HN201605. Twenty-five PRRSV- and antibody-free pigs were randomly divided into the following five groups: Vac/ChA, Unvac/ChA, Vac/ChB, Unvac/ChB and the mock. The pigs in groups Vac/ChA and Vac/ChB were inoculated intramuscularly with 1 mL TJM-F92 (105...
March 29, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29594957/exhaustive-exercise-does-not-affect-humoral-immunity-and-protection-after-rabies-vaccination-in-a-mouse-model
#10
Lun Xia, Minrui Li, Yajing Zhang, Juncheng Ruan, Jie Pei, Jiale Shi, Zhen F Fu, Ling Zhao, Ming Zhou, Dayong Tian
Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and the humoral immune response after immunization with inactivated rabies vaccine was investigated in a mouse model with one-time exhaustive exercise. It was found that compared with the mice with no exercise after vaccination, no significant differences were found in those with exhaustive exercise after vaccination on body-weight changes, virus-neutralizing antibody (VNA) titers, antibody subtypes and survivor ratio after lethal rabies virus (RABV) challenge...
March 28, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29594956/mechanisms-and-effects-on-hbv-replication-of-the-interaction-between-hbv-core-protein-and-cellular-filamin-b
#11
Yilin Li, Yishuang Sun, Fuyun Sun, Rong Hua, Chenlin Li, Lang Chen, Deyin Guo, Jingfang Mu
Hepatitis B virus (HBV) infection is one of the major problems that threatens global health. There have been many studies on HBV, but the relationship between HBV and host factors is largely unexplored and more studies are needed to clarify these interactions. Filamin B is an actin-binding protein that acts as a cytoskeleton protein, and it is involved in cell development and several signaling pathways. In this study, we showed that filamin B interacted with HBV core protein, and the interaction promoted HBV replication...
March 28, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29569145/first-serological-evidence-on-endemicity-of-hev-infection-in-wild-boar-sus-scrofa-populations-from-portugal
#12
LETTER
Daniel Gonçalves, João Pereira-Vaz, Vitor Duque, Victor Bandeira, Carlos Fonseca, Ana Donato, Cristina Luxo, Ana Miguel Matos
No abstract text is available yet for this article.
March 22, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29569144/a-highly-pathogenic-strain-of-porcine-deltacoronavirus-caused-watery-diarrhea-in-newborn-piglets
#13
Zhichao Xu, Huiling Zhong, Qingfeng Zhou, Yunping Du, Li Chen, Yun Zhang, Chunyi Xue, Yongchang Cao
Porcine deltacoronavirus (PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and mainland China. Here we isolated a strain of PDCoV, named CHN-GD-2016, from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy...
March 22, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29549651/characteristics-of-hiv-1-molecular-epidemiology-in-suzhou-china-from-2009-to-2014
#14
LETTER
Ying Yuan, Shengjie Tang, Yuan Li, Dongmei Yan, Qunxin Peng, Xuerong Ya, Yanhui Song
No abstract text is available yet for this article.
March 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29549650/hearnpv-pseudotyped-with-pif1-2-and-3-from-mabrnpv-infectivity-and-complex-stability
#15
George Alliwa Makalliwa, Xi Wang, Huanyu Zhang, Nan Zhang, Cheng Chen, Jiang Li, Fei Deng, Hualin Wang, Manli Wang, Zhihong Hu
Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) with their homologs from Mamestra bracissae multiple nucleopolyhedrovirus and tested their infectivity to tissue culture cells and to larvae. Transfection and infection assays revealed that all recombinant viruses generated infectious budded virus in both cell culture and in larvae...
March 16, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29546673/the-regulation-of-cgas
#16
Meiguang Xiong, Suyun Wang, Yan-Yi Wang, Yong Ran
The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases...
March 15, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29541944/nap1l1-regulates-hepatitis-c-virus-entry-and-interacts-with-ns3
#17
LETTER
Peiqi Yin, Ye Li, Liya Zhou, Leiliang Zhang
No abstract text is available yet for this article.
March 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29541943/differential-effects-of-strategies-to-improve-the-transduction-efficiency-of-lentiviral-vector-that-conveys-an-anti-hiv-protein-nullbasic-in-human-t-cells
#18
Lina Rustanti, Hongping Jin, Dongsheng Li, Mary Lor, Haran Sivakumaran, David Harrich
Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting three different steps of viral replication: reverse transcription, Rev export of viral mRNA from the nucleus to the cytoplasm and transcription of viral mRNA by RNA polymerase II. We previously showed that Nullbasic inhibits transduction of human cells including T cells by HIV-1-based lentiviral vectors. Here we investigated whether the Nullbasic antagonists huTat2 (a Tat targeting intrabody), HIV-1 Tat or Rev proteins or cellular DDX1 protein could improve transduction by a HIV-1 lentiviral vector conveying Nullbasic-ZsGreen1 to human T cells...
March 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29541942/recent-advances-in-animal-models-of-zika-virus-infection
#19
Shupeng Dong, Qiming Liang
An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was previously observed to cause only mild flu-like symptoms. However, recent ZIKV infections might be responsible for the increasing cases of neurological disorders such as Guillain-Barré syndrome and congenital defects, including newborn microcephaly...
March 14, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29541941/evaluation-of-antibody-dependent-enhancement-of-sars-cov-infection-in-rhesus-macaques-immunized-with-an-inactivated-sars-cov-vaccine
#20
LETTER
Fan Luo, Fan-Lu Liao, Hui Wang, Hong-Bin Tang, Zhan-Qiu Yang, Wei Hou
No abstract text is available yet for this article.
March 14, 2018: Virologica Sinica
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