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Virologica Sinica

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https://www.readbyqxmd.com/read/28063012/a-novel-mosquito-borne-reassortant-orbivirus-isolated-from-xishuangbanna-china
#1
LETTER
Shaozhen Xing, Xiaofang Guo, Xianglilan Zhang, Qiumin Zhao, Lingli Li, Shuqing Zuo, Xiaoping An, Guangqian Pei, Qiang Sun, Shi Cheng, Yunfei Wang, Hang Fan, Zhiqiang Mi, Yong Huang, Zhiyi Zhang, Hongning Zhou, Jiusong Zhang, Yigang Tong
No abstract text is available yet for this article.
December 30, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27995422/entry-of-severe-fever-with-thrombocytopenia-syndrome-virus
#2
REVIEW
Fei Yuan, Aihua Zheng
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a globe-shaped virus covered by a dense icosahedral array of glycoproteins Gn/Gc that mediate the attachment of the virus to host cells and the fusion of viral and cellular membranes. Several membrane factors are involved in virus entry, including C-type lectins and nonmuscle myosin heavy chain IIA. The post-fusion crystal structure of the Gc protein suggests that it is a class II membrane fusion protein, similar to the E/E1 protein of flaviviruses and alphaviruses...
December 16, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853993/the-roles-of-ebolavirus-glycoproteins-in-viral-pathogenesis
#3
REVIEW
Yun-Jia Ning, Fei Deng, Zhihong Hu, Hualin Wang
Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics...
November 14, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853992/progress-towards-understanding-the-pathogenesis-of-dengue-hemorrhagic-fever
#4
REVIEW
Xiaojing Pang, Rudian Zhang, Gong Cheng
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses...
November 14, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063014/roles-of-i%C3%AE%C2%BAb-kinase-%C3%AE%C2%B5-in-the-innate-immune-defense-and-beyond
#5
REVIEW
Junjie Zhang, Mao Tian, Zanxian Xia, Pinghui Feng
IκB kinase ε (IKKε) is a non-canonical IκB kinase that is extensively studied in the context of innate immune response. Recently, significant progress has been made in understanding the role of IKKε in interferon (IFN) signaling. In addition to its roles in innate immunity, recent studies also demonstrate that IKKε is a key regulator of the adaptive immune response. Specifically, IKKε functions as a negative feedback kinase to curtail CD8 T cell response, implying that it can be a potential therapeutic target to boost antiviral and antitumor T cell immunity...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28063013/the-role-of-micrornas-in-hepatocyte-metabolism-and-hepatitis-b-virus-replication
#6
REVIEW
Wanyu Deng, Mengji Lu
Though efficient vaccines against hepatitis B virus (HBV) and antiviral therapies are available, chronic HBV infection is still a global health problem. The process of HBV infection and HBV life cycle are extensively studied in last decades, however, the mechanisms of HBV-induced alterations of host cell metabolisms and host factors involved in modulating of viral replication are not fully understood. Thus, it is an important issue to examine these specific HBV-host interactions for development of novel strategies for antiviral therapies...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/28000060/a-new-strategy-for-full-length-ebola-virus-glycoprotein-expression-in-e-coli
#7
Junjie Zai, Yinhua Yi, Han Xia, Bo Zhang, Zhiming Yuan
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression of full-length GP in Escherichia coli hinders the further study of its function in viral pathogenesis. In this study, the vp40 gene was fused to the full-length gp gene and cloned into a prokaryotic expression vector...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27995421/characterization-of-two-monoclonal-antibodies-38f10-and-44d11-against-the-major-envelope-fusion-protein-of-helicoverpa-armigera-nucleopolyhedrovirus
#8
Zijiao Zou, Jinliang Liu, Zhiying Wang, Fei Deng, Hualin Wang, Zhihong Hu, Manli Wang, Tao Zhang
The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor (F0) and then cleaved into a disulfide-linked F1 and F2 subunits during the process of protein maturation and secretion. To facilitate further investigation into the structure and function of F protein during virus infection, monoclonal antibodies (mAbs) against the F2 subunit of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) (HaF) were generated...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933565/kshv-strategies-for-host-dsdna-sensing-machinery
#9
REVIEW
Hang Gao, Yanyan Song, Chengrong Liu, Qiming Liang
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933564/an-improved-reverse-genetics-system-for-newcastle-disease-virus-genotype-vii
#10
LETTER
Yuzhang Sun, Mingjun Sun, Yonglian Dai, Renfu Yin, Zhuang Ding
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27909863/distribution-and-molecular-variability-of-four-tobacco-viruses-in-china
#11
LETTER
Kuan Wu, Wei Chen, Zhaopeng Luo, Bing Wang, Julong Cheng, Zhensheng Kang
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900558/the-role-of-viral-protein-ac34-in-nuclear-relocation-of-subunits-of-the-actin-related-protein-2-3-complex
#12
Jingfang Mu, Yongli Zhang, Yangyang Hu, Xue Hu, Yuan Zhou, Xinwen Chen, Yun Wang
The actin nucleator actin-related protein complex (Arp2/3) is composed of seven subunits: Arp2, Arp3, p40/ARPC1 (P40), p34/ARPC2 (P34), p21/ARPC3 (P21), p20/ARPC4 (P20), and p16/ARPC5 (P16). Arp2/3 plays crucial roles in a variety of cellular activities through regulation of actin polymerization. Autographa californica multiple nucleopolyhedrovirus (AcMNPV), one of the beststudied alphabaculoviruses, induces Arp2/3 nuclear relocation and mediates nuclear actin polymerization to assist in virus replication. We have demonstrated that Ac34, a viral late-gene product, induces translocation of the P40 subunit of Arp2/3 to the nucleus during AcMNPV infection...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900557/primary-ebv-infection-and-hypersensitivity-to-mosquito-bites-a-case-report
#13
LETTER
Ioannis Kyriakidis, Eleni Vasileiou, Sofia Karastrati, Athanasios Tragiannidis, Nikolaos Gompakis, Maria Hatzistilianou
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853991/detection-and-pathogenesis-of-a-novel-swine-h3n2-influenza-virus-containing-three-genes-from-the-2009-pandemic-h1n1-influenza-viruses-in-korea-in-2015
#14
LETTER
Tran Bac Le, In Hong Lee, Byung Jun Kim, Hyun Soo Kim, Sang Heui Seo
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27838882/amino-acids-essential-for-the-interaction-between-cellular-heat-shock-protein-90-and-a-kaposi-s-sarcoma-associated-herpesvirus-encoded-protein-kinase-orf36
#15
LETTER
Chao Wang, Jingchao Wang, Wei Guo, Cong Long, Huan Wang, Xiaoping Sun
No abstract text is available yet for this article.
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822719/hpv18-dna-replication-inactivates-the-early-promoter-p55-activity-and-prevents-viral-e6-expression
#16
LETTER
Xiaohong Wang, Haibin Liu, Hsu-Kun Wang, Craig Meyers, Louise Chow, Zhi-Ming Zheng
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822718/pitfalls-of-restriction-enzyme-analysis-in-identifying-characterizing-typing-and-naming-viral-pathogens-in-the-era-of-whole-genome-data-as-illustrated-by-hadv-type-55
#17
Qiwei Zhang, Shoaleh Dehghan, Donald Seto
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822717/import-of-rift-valley-fever-to-china-a-potential-new-threat
#18
Xinliang Fu, Lifang Wang, Bo Fang, Ruirui Ma, Yun Zheng, San Huang, Pei Zhou, Zongxi Cao, Jin Tian, Shoujun Li, Guihong Zhang
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822716/three-dimensional-cell-culture-models-for-investigating-human-viruses
#19
REVIEW
Bing He, Guomin Chen, Yi Zeng
Three-dimensional (3D) culture models are physiologically relevant, as they provide reproducible results, experimental flexibility and can be adapted for high-throughput experiments. Moreover, these models bridge the gap between traditional two-dimensional (2D) monolayer cultures and animal models. 3D culture systems have significantly advanced basic cell science and tissue engineering, especially in the fields of cell biology and physiology, stem cell research, regenerative medicine, cancer research, drug discovery, and gene and protein expression studies...
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27770381/de-novo-transcriptome-analysis-of-spodoptera-exigua-multiple-nucleopolyhedrovirus-semnpv-genes-in-latently-infected-se301-cells
#20
Zheng Fang, Jingxu Shao, Qingbei Weng
Cells of the P8-Se301-C1 strain are Spodoptera exigua cell clones that each harbor a partial version of the S. exigua multiple nucleopolyhedrovirus (SeMNPV) genome and which are resistant to homologous SeMNPV infections. The cells produce no viral progeny, suggesting that the infection is a latent-like viral infection. To investigate the SeMNPV genes harbored in the P8-Se301-C1 cells, the de novo transcriptomes of P8-Se301-C1 cells and S. exigua Se301 cells were analyzed and compared. A total of 54,569,296 reads were obtained from the P8-Se301-C1 cells that yielded 112,565 final unigenes with a mean length of 1,093 nt...
October 2016: Virologica Sinica
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