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Virologica Sinica

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https://www.readbyqxmd.com/read/28795354/drug-resistance-mutation-profiles-of-the-drug-na%C3%A3-ve-and-first-line-regimen-treated-hiv-1-infected-population-of-suzhou-china
#1
Tingting Li, Feng Qian, Ting Yuan, Weilu Xu, Li Zhu, Jinlong Huang, Haiyan Wang, Yueping Zhu, Yinling Wang, Xiaohong Li, Saihong Gu, Zhuqing Tan, Hui Chen, Xiangrong Luo, Wei Zhu, Wenjuan Lu, Ping Xu, Ming Li, Yuying Chen, Yong Gao, Rongge Yang, Chuanwu Zhu, Binlian Sun
Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance (TDR) and acquired drug resistance mutation (ADR) profiles, we collected blood specimens from 127 drug-naïve and 117 first-line drug-treated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified pol fragments from 100 drug-naïve and 20 drug-treated samples. We then determined the drug-resistant mutations to protease (PR) and reverse-transcriptase (RT) inhibitors according to the Stanford drug resistance database...
August 7, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28795353/reconciling-individual-and-population-levels-of-porcine-reproductive-and-respiratory-syndrome-virus-evolution
#2
LETTER
Giovanni Franzo, Claudia Maria Tucciarone, Mattia Cecchinato, Michele Drigo
No abstract text is available yet for this article.
August 7, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28755162/coexistence-of-multiple-genotypes-of-porcine-epidemic-diarrhea-virus-with-novel-mutant-s-genes-in-the-hubei-province-of-china-in-2016
#3
Zhe Zeng, Ting-Ting Li, Xin Jin, Fu-Hu Peng, Nian-Hua Song, Gui-Qing Peng, Xing-Yi Ge
The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010. Since then, large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China. However, the molecular diversity and epidemiology of PEDV in different provinces has not been completely understood. To determine the molecular diversity of PEDV in the Hubei Province of China, we collected 172 PED samples from 34 farms across the province in 2016 and performed reverse transcription polymerase chain reaction (RTPCR) by targeting the nucleocapsid (N) gene...
July 26, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28744727/host-protein-atlastin-1-promotes-human-immunodeficiency-virus-hiv-1-replication
#4
LETTER
Wenyuan Shen, Bin Liu, Zhou Liu, Jiabin Feng, Chang Liu, Xiaohong Kong
No abstract text is available yet for this article.
July 24, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28744726/evaluation-of-purified-recombinant-spike-fragments-for-assessment-of-the-presence-of-serum-neutralizing-antibodies-against-a-variant-strain-of-porcine-epidemic-diarrhea-virus
#5
Jianwei Hao, Yun Zhang, Shengkun Fang, Zhifen Wen, Xiangbin Zhang, Chunyi Xue, Yongchang Cao
Since 2010, variant strains of porcine epidemic diarrhea virus (PEDV) have caused disasters in the pork industry. The spike (S) protein, as the major immunity-eliciting antigen, has previously been used for serological testing and has been found to correlate significantly with the results of the serum neutralization (SN) test. However, further evaluation of this method is needed as new epidemic strains of PEDV emerge. Hence, the main objective of this study was to assess sow sera and determine the correlation between enzyme-linked immunosorbent assay (ELISA) results (involving a newly isolated GDS01 virus-based ELISA and ELISAs based on seven recombinant fragments comprising overlapping S1 and partial S2 sequences) and SN titers...
July 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28721632/detection-and-characterization-of-three-zoonotic-viruses-in-wild-rodents-and-shrews-from-shenzhen-city-china
#6
Bo Wang, Chun-Lin Cai, Bei Li, Wei Zhang, Yan Zhu, Wei-Hong Chen, Fei Zhuo, Zheng-Li Shi, Xing-Lou Yang
Diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential. Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. To determine the distribution of zoonotic viruses in Shenzhen city, the major city in southern China with a high population density, we analyzed 225 rodents (Rattus norvegicus and Rattus flavipectus) and 196 shrews (Suncus murinus) from urban and rural districts for the presence of mammarenavirus, hantavirus, and hepatitis E virus (HEV) by RT-PCR targeting the conserved regions...
July 17, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28674773/influenza-a-virus-induced-downregulation-of-mir-26a-contributes-to-reduced-ifn%C3%AE-%C3%AE-production
#7
Shijuan Gao, Jiandong Li, Liping Song, Jiaoxiang Wu, Wenlin Huang
Innate immunity provides immediate defense against viral infection. Influenza A virus (IAV) is able to get past the first line of defense. Elucidation of the molecular interaction between influenza factors and the newly recognized host players in the innate response might help in our understanding of the root causes of virulence and pathogenicity of IAV. In this study, we show that expression of miR-26a leads to a significant inhibition of IAV replication. miR-26a does not directly target IAV genome. Instead, miR-26a activates the type I interferon (IFN) signaling pathway and promotes the production of IFN-stimulated genes, thus suppressing viral replication...
June 30, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28646484/a-practical-approach-to-generate-suitable-de-novo-synthesis-rna-template-for-a-flavivirus-rna-dependent-rna-polymerase
#8
LETTER
Wei Shi, Peng Gong
No abstract text is available yet for this article.
June 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28643195/a-convenient-immunochromatographic-test-strip-for-rapid-detection-of-scylla-serrata-reovirus
#9
LETTER
Dongyang Fan, Jingwen Liu, Miaomiao Xu, Yangyang Yuan, Jifang Yang, Jigang Chen
No abstract text is available yet for this article.
June 20, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28550493/cypovirus-capsid-protein-vp5-has-nucleoside-triphosphatase-activity
#10
LETTER
Jie Yang, Qi Qian, Teng-Feng Li, Xueli Yang, Sok Jin Won, Xi Zhou
No abstract text is available yet for this article.
May 26, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28669005/phylogenetic-analysis-based-on-mitochondrial-dna-sequences-of-wild-rats-and-the-relationship-with-seoul-virus-infection-in-hubei-china
#11
Dong-Ying Liu, Jing Liu, Bing-Yu Liu, Yuan-Yuan Liu, Hai-Rong Xiong, Wei Hou, Zhan-Qiu Yang
Seoul virus (SEOV), which is predominantly carried by Rattus norvegicus, is one of the major causes of hemorrhagic fever with renal syndrome (HFRS) in China. Hubei province, located in the central south of China, has experienced some of the most severe epidemics of HFRS. To investigate the mitochondrial DNA (mtDNA)-based phylogenetics of wild rats in Hubei, and the relationship with SEOV infection, 664 wild rats were captured from five trapping sites in Hubei from 2000-2009 and 2014-2015. Using reverse-transcription (RT)-PCR, 41 (6...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28669004/an-update-epstein-barr-virus-and-immune-evasion-via-microrna-regulation
#12
REVIEW
Lielian Zuo, Wenxin Yue, Shujuan Du, Shuyu Xin, Jing Zhang, Lingzhi Liu, Guiyuan Li, Jianhong Lu
Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. To ensure its survival and maintain its B cell transformation function, EBV has developed powerful strategies to evade host immune responses. Emerging evidence has shown that microRNAs (miRNAs) are powerful regulators of the maintenance of cellular homeostasis. In this review, we summarize current progress on how EBV utilizes miRNAs for immune evasion. EBV encodes miRNAs targeting both viral and host genes involved in the immune response...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28656540/human-endogenous-retrovirus-w-env-increases-nitric-oxide-production-and-enhances-the-migration-ability-of-microglia-by-regulating-the-expression-of-inducible-nitric-oxide-synthase
#13
Ran Xiao, Shan Li, Qian Cao, Xiuling Wang, Qiujin Yan, Xiaoning Tu, Ying Zhu, Fan Zhu
Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter-nitric oxide (NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28634871/rabies-virus-co-localizes-with-early-rab5-and-late-rab7-endosomal-proteins-in-neuronal-and-sh-sy5y-cells
#14
Waqas Ahmad, Yingying Li, Yidi Guo, Xinyu Wang, Ming Duan, Zhenhong Guan, Zengshan Liu, Maolin Zhang
Rabies virus (RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and pH-dependent pathway for trafficking and invasion into endothelial cells. Early (Rab5, EEA1) and late (Rab7, LAMP1) endosomal proteins play critical roles in endosomal sorting, maturity and targeting various molecular cargoes, but their precise functions in the early stage of RABV neuronal infection remain elusive. In this study, the relationship between enigmatic entry of RABV with these endosomal proteins into neuronal and SH-SY5Y cells was investigated...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28593536/molecular-typing-of-non-polio-enteroviruses-isolated-from-acute-flaccid-paralysis-cases-in-iran-from-2010-to-2015
#15
LETTER
Ahmad Nejati, Mohammad Farahmand, Hamideh Tabatabaie, Maryam Yousefi, Yaghoob Mollaei-Kandelous, Shohreh Shahmahmoodi
No abstract text is available yet for this article.
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28589292/detection-of-diverse-viruses-in-alimentary-specimens-of-bats-in-macau
#16
Jie Liang, Xing-Lou Yang, Bei Li, Qi Liu, Qin Zhang, Hui Liu, Hon-Pio Kan, Kai-Chin Wong, Si-Nga Chek, Xiangyang He, Xingwen Peng, Zheng-Li Shi, Yi Wu, Libiao Zhang
Bats carry a variety of viruses, and some of them cause public health problems. Macau, which is famous for its gambling industry, has a complex population structure. The globalization in such an international metropolis has enhanced the chance of disease transmission. Therefore, surveillance of zoonotic viruses is necessary for the early warning of potential emerging infectious diseases. Here, we report the first surveillance of bat viruses in Macau. In this study, we collected 1004 samples involving 10 bat species from 7 sites from April 2015 to May 2016, and examined the presence of viruses using nucleic acid-based methods...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28530022/development-of-a-reverse-transcription-quantitative-polymerase-chain-reaction-based-assay-for-broad-coverage-detection-of-african-and-asian-zika-virus-lineages
#17
Yang Yang, Gary Wong, Baoguo Ye, Shihua Li, Shanqin Li, Haixia Zheng, Qiang Wang, Mifang Liang, George F Gao, Lei Liu, Yingxia Liu, Yuhai Bi
The Zika virus (ZIKV) is an arbovirus that has spread rapidly worldwide within recent times. There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome (GBS) and microcephaly in humans. The ZIKV is genetically diverse and can be separated into Asian and African lineages. A rapid, sensitive, and specific assay is needed for the detection of ZIKV across various pandemic regions. So far, the available primers and probes do not cover the genetic diversity and geographic distribution of all ZIKV strains...
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28516317/cd95-cd95l-interaction-mediates-the-growth-control-of-mhv68-immortalized-b-cells-by-cytotoxic-t-cells
#18
LETTER
Sihan Dong, Lingbing Tan, Guifang Chen, Xiaozhen Liang
No abstract text is available yet for this article.
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28474298/isolation-and-phylogenetic-study-of-rift-valley-fever-virus-from-the-first-imported-case-to-china
#19
LETTER
Yongxia Shi, Kui Zheng, Xiaobo Li, Liqiang Li, Shufen Li, Jinmin Ma, Jun Dai, Jingkai Ji, Shuai Yuan, Haorong Lu, Jiandong Li, Fangfang Sun, Xun Xu, Jicheng Huang
No abstract text is available yet for this article.
June 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28451898/human-cytomegalovirus-infection-dysregulates-neural-progenitor-cell-fate-by-disrupting-hes1-rhythm-and-down-regulating-its-expression
#20
Xi-Juan Liu, Xuan Jiang, Sheng-Nan Huang, Jin-Yan Sun, Fei Zhao, Wen-Bo Zeng, Min-Hua Luo
Human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. As the essential downstream effector of Notch signaling pathway, Hes1, and its dynamic expression, plays an essential role on maintaining neural progenitor /stem cells (NPCs) cell fate and fetal brain development. In the present study, we reported the first observation of Hes1 oscillatory expression in human NPCs, with an approximately 1.5 hour periodicity and a Hes1 protein half-life of about 17 (17...
June 2017: Virologica Sinica
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