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Virologica Sinica

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https://www.readbyqxmd.com/read/27933565/kshv-strategies-for-host-dsdna-sensing-machinery
#1
REVIEW
Hang Gao, Yanyan Song, Chengrong Liu, Qiming Liang
The innate immune system utilizes pattern recognition receptors cyclic GMP-AMP synthase (cGAS) to sense cytosolic double-stranded (ds) DNA and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. The genomes of herpesviruses are large dsDNA, which represent a major class of pathogen signatures recognized by cellular DNA sensor cGAS. However, to successfully establish the persistent infection, herpesviruses have evolved their viral genes to modulate different aspects of host immune signaling...
December 5, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27933564/an-improved-reverse-genetics-system-for-newcastle-disease-virus-genotype-vii
#2
LETTER
Yuzhang Sun, Mingjun Sun, Yonglian Dai, Renfu Yin, Zhuang Ding
No abstract text is available yet for this article.
December 5, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900558/the-role-of-viral-protein-ac34-in-nuclear-relocation-of-subunits-of-the-actin-related-protein-2-3-complex
#3
Jingfang Mu, Yongli Zhang, Yangyang Hu, Xue Hu, Yuan Zhou, Xinwen Chen, Yun Wang
The actin nucleator actin-related protein complex (Arp2/3) is composed of seven subunits: Arp2, Arp3, p40/ARPC1 (P40), p34/ARPC2 (P34), p21/ARPC3 (P21), p20/ARPC4 (P20), and p16/ARPC5 (P16). Arp2/3 plays crucial roles in a variety of cellular activities through regulation of actin polymerization. Autographa californica multiple nucleopolyhedrovirus (AcMNPV), one of the best-studied alphabaculoviruses, induces Arp2/3 nuclear relocation and mediates nuclear actin polymerization to assist in virus replication...
December 5, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27909863/distribution-and-molecular-variability-of-four-tobacco-viruses-in-china
#4
LETTER
Kuan Wu, Wei Chen, Zhaopeng Luo, Bing Wang, Julong Cheng, Zhensheng Kang
No abstract text is available yet for this article.
November 29, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27900557/primary-ebv-infection-and-hypersensitivity-to-mosquito-bites-a-case-report
#5
LETTER
Ioannis Kyriakidis, Eleni Vasileiou, Sofia Karastrati, Athanasios Tragiannidis, Nikolaos Gompakis, Maria Hatzistilianou
No abstract text is available yet for this article.
November 28, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853991/detection-and-pathogenesis-of-a-novel-swine-h3n2-influenza-virus-containing-three-genes-from-the-2009-pandemic-h1n1-influenza-viruses-in-korea-in-2015
#6
LETTER
Tran Bac Le, In Hong Lee, Byung Jun Kim, Hyun Soo Kim, Sang Heui Seo
No abstract text is available yet for this article.
November 15, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853993/the-roles-of-ebolavirus-glycoproteins-in-viral-pathogenesis
#7
REVIEW
Yun-Jia Ning, Fei Deng, Zhihong Hu, Hualin Wang
Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. The majority of ebolavirus species, most notably Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against EVD. Understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics...
November 14, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27853992/progress-towards-understanding-the-pathogenesis-of-dengue-hemorrhagic-fever
#8
REVIEW
Xiaojing Pang, Rudian Zhang, Gong Cheng
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses...
November 14, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27838882/amino-acids-essential-for-the-interaction-between-cellular-heat-shock-protein-90-and-a-kaposi-s-sarcoma-associated-herpesvirus-encoded-protein-kinase-orf36
#9
LETTER
Chao Wang, Jingchao Wang, Wei Guo, Cong Long, Huan Wang, Xiaoping Sun
No abstract text is available yet for this article.
November 10, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27770381/de-novo-transcriptome-analysis-of-spodoptera-exigua-multiple-nucleopolyhedrovirus-semnpv-genes-in-latently-infected-se301-cells
#10
Zheng Fang, Jingxu Shao, Qingbei Weng
Cells of the P8-Se301-C1 strain are Spodoptera exigua cell clones that each harbor a partial version of the S. exigua multiple nucleopolyhedrovirus (SeMNPV) genome and which are resistant to homologous SeMNPV infections. The cells produce no viral progeny, suggesting that the infection is a latent-like viral infection. To investigate the SeMNPV genes harbored in the P8-Se301-C1 cells, the de novo transcriptomes of P8-Se301-C1 cells and S. exigua Se301 cells were analyzed and compared. A total of 54,569,296 reads were obtained from the P8-Se301-C1 cells that yielded 112,565 final unigenes with a mean length of 1,093 nt...
October 18, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27681265/identification-of-interaction-between-hiv-1-glycoprotein-41-and-integrase
#11
Xiaowei Zhang, Fei Zhang, Xiaohe Ma, Xing Zhao, Wei Li, Zhiping Zhang, Jibin Zhang, Xian-En Zhang, Zongqiang Cui
Human immunodeficiency virus-1 (HIV-1) encodes 15 viral proteins. Protein-protein interactions play a large role in the function of these proteins. In this study, we attempted to identify novel interactions between the HIV-1 proteins to better understand the role played by viral protein-protein interactions in the life cycle of HIV-1. Genes encoding the 15 viral proteins from the HIV-1 strain AD8 were inserted into the plasmids of a yeast two-hybrid system. By screening 120 pairs of proteins, interactions between seven pairs were found...
September 26, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27699612/a-quantitative-rt-pcr-assay-for-rapid-detection-of-eurasian-lineage-h10-subtype-influenza-a-virus
#12
Hailiang Sun, Jian-Li Xue, Elizabeth Bailey, Yifei Xu, Guoliang Hu, John Baroch, Yi Zhang, Lanny Pace, Thomas J DeLiberto, Xiu-Feng Wan
No abstract text is available yet for this article.
September 18, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27624182/manipulation-of-the-host-cell-membrane-by-human-%C3%AE-herpesviruses-ebv-and-kshv-for-pathogenesis
#13
Fang Wei, Qing Zhu, Ling Ding, Qing Liang, Qiliang Cai
The cell membrane regulates many physiological processes including cellular communication, homing and metabolism. It is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. Among these, the human oncogenic herpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) exploit the host cell membrane to avoid immune surveillance and promote viral replication. Accumulating evidence has shown that both EBV and KSHV directly encode several similar membrane-associated proteins, including receptors and receptor-specific ligands (cytokines and chemokines), to increase virus fitness in spite of host antiviral immune responses...
September 12, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822719/hpv18-dna-replication-inactivates-the-early-promoter-p55-activity-and-prevents-viral-e6-expression
#14
LETTER
Xiaohong Wang, Haibin Liu, Hsu-Kun Wang, Craig Meyers, Louise Chow, Zhi-Ming Zheng
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822718/pitfalls-of-restriction-enzyme-analysis-in-identifying-characterizing-typing-and-naming-viral-pathogens-in-the-era-of-whole-genome-data-as-illustrated-by-hadv-type-55
#15
Qiwei Zhang, Shoaleh Dehghan, Donald Seto
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822717/import-of-rift-valley-fever-to-china-a-potential-new-threat
#16
Xinliang Fu, Lifang Wang, Bo Fang, Ruirui Ma, Yun Zheng, San Huang, Pei Zhou, Zongxi Cao, Jin Tian, Shoujun Li, Guihong Zhang
No abstract text is available yet for this article.
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27822716/three-dimensional-cell-culture-models-for-investigating-human-viruses
#17
REVIEW
Bing He, Guomin Chen, Yi Zeng
Three-dimensional (3D) culture models are physiologically relevant, as they provide reproducible results, experimental flexibility and can be adapted for high-throughput experiments. Moreover, these models bridge the gap between traditional two-dimensional (2D) monolayer cultures and animal models. 3D culture systems have significantly advanced basic cell science and tissue engineering, especially in the fields of cell biology and physiology, stem cell research, regenerative medicine, cancer research, drug discovery, and gene and protein expression studies...
October 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27576476/ficolin-2-binds-to-hiv-1-gp120-and-blocks-viral-infection
#18
Fengling Luo, Tielong Chen, Jun Liu, Xihui Shen, Yinnan Zhao, Rongge Yang, Xiaolian Zhang
Ficolin-2 is a lectin complement pathway activator present in normal human plasma and usually associated with infectious diseases, but little is known about the role of ficolin-2 in human immunodeficiency virus (HIV) infection. Here, we describe our novel findings that serum ficolin-2 concentrations of 103 HIV-1 patients were much higher compared to those of 57 healthy donors. In vitro analysis showed that HIV-1 infection could enhance ficolin-2 expression. We further demonstrated that recombinant ficolin-2 protein could bind with HIV-1 envelope glycoprotein gp120, and subsequently induce complement dependent cytotoxicity...
August 29, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27526036/large-discrepancy-between-the-two-way-rnht-distances-in-hemagglutinin-inhibition-assay
#19
Yousong Peng, Dayan Wang, Yuelong Shu, Taijiao Jiang
No abstract text is available yet for this article.
August 9, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27562602/structure-function-relationship-of-the-mammarenavirus-envelope-glycoprotein
#20
Wei Wang, Zheng Zhou, Leike Zhang, Shaobo Wang, Gengfu Xiao
Mammarenaviruses, including lethal pathogens such as Lassa virus and Junín virus, can cause severe hemorrhagic fever in humans. Entry is a key step for virus infection, which starts with binding of the envelope glycoprotein (GP) to receptors on target cells and subsequent fusion of the virus with target cell membranes. The GP precursor is synthesized as a polypeptide, and maturation occurs by two cleavage events, yielding a tripartite GP complex (GPC) formed by a stable signal peptide (SSP), GP1 and GP2. The unique retained SSP interacts with GP2 and plays essential roles in virion maturation and infectivity...
August 4, 2016: Virologica Sinica
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