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Cancer Management and Research

Hui Ye, Meiling Duan
Introduction: Forkhead box (FOX) N2 (FOXN2), a member of FOX protein family, has been reported to play critical roles in some types of cancers. However, the expression and function of FOXN2 in breast cancer remain unclear. Methods: In the present work, we explored the detailed molecular mechanism of FOXN2 in breast cancer. We performed RT-qPCR and Western blotting analysis to detect the expression of FOXN2 in breast cancer. Colony formation assay, CCK-8 assay, wound healing assay, and Transwell assay were used to determine the effect of FOXN2 on cell proliferation, migration, and invasion in breast cancer...
2019: Cancer Management and Research
Reshma L Mahtani, Charles L Vogel
Combination therapy with a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor and an aromatase inhibitor (AI) for first-line treatment of postmenopausal women with advanced breast cancer (ABC) has demonstrated improvement in progression-free survival (PFS) over AI monotherapy without adding substantial toxicity. However, CDK4/6 inhibitor plus AI therapy is not uniformly used as first-line therapy for ABC, indicating that barriers to CDK4/6 inhibitor use exist. Such barriers may include the following perceptions: patients with bone-only metastases, with a long disease-free interval, or who are older may respond to AI monotherapy and may not benefit from a CDK4/6 inhibitor; tumor response rates may be lower and delayed with CDK4/6 inhibitor plus AI therapy than chemotherapy; the increased incidence of adverse events with CDK4/6 inhibitor plus AI therapy outweighs benefits; and the cost of CDK4/6 inhibitors may be prohibitive...
2019: Cancer Management and Research
Li Li, Wei Liang, Jin-Xian Zhu, Chun-Jie Dong, Yuan-Mei Zou, Bi-Cui Ye, Lin Gao
Purpose: The role of chemotherapy has evolved greatly in advanced nasopharyngeal carcinoma (NPC). We undertook this network meta-analysis to establish the optimal chemotherapy strategy in advanced NPC. Materials and methods: This network meta-analysis recruited randomized clinical trials involving patients with advanced NPC randomly allocated to induction chemotherapy plus concurrent chemoradiotherapy (CRT; induction + CRT), CRT plus adjuvant chemotherapy (CRT + adjuvant), CRT or radiotherapy (RT) alone...
2019: Cancer Management and Research
Asit Ray, Sudipta Jena, Biswabhusan Dash, Ambika Sahoo, Basudeba Kar, Jeetendranath Patnaik, Pratap Chandra Panda, Sanghamitra Nayak, Namita Mahapatra
Background: Hedychium coronarium Koen. (Zingiberaceae) is traditionally used as medicine in countries such as India, China, and Vietnam for treatment of various ailments including cancer. However, in spite of its implied significance in cancer treatment regimes, there are no reports so far involving the anticancerous attributes of H, coronarium ethanol extract (HCEE) on cancer cells and a more comprehensive study on its mechanism is still lacking. Materials and methods: The cytotoxicity of HCEE was evaluated by MTT and clonogenic survival assay...
2019: Cancer Management and Research
Kashif Asghar, Asif Loya, Iftikhar Ali Rana, Muhammad Tahseen, Muhammad Ishaq, Asim Farooq, Muhammad Abu Bakar, Iqra Masood
Background: Immune dysfunction in breast cancer patients is well established. Indoleamine 2,3-dioxygenase (IDO) is an immunosuppressive enzyme that is linked with progression of cancer. IDO is overexpressed in triple-negative breast cancer (TNBC) cases. Materials and methods: We conducted the first study to analyze IDO expression and overall survival in breast cancer cases in Pakistan. Expression of IDO, estrogen receptor (ER), progesterone receptor (PR), and human EGF receptor 2 (HER2) was evaluated by immunohistochemistry...
2019: Cancer Management and Research
Tianji Liu, Wenqi Zhang, Shuai Xiao, Lei Xu, Qiang Wen, Lin Bai, Qingjie Ma, Bin Ji
Objective: The aim of this study was to evaluate the efficacy of mindfulness-based stress reduction (MBSR) on health-related quality of life (QoL), depression, and anxiety in patients with differentiated thyroid cancer (DTC) receiving radioactive iodine therapy (RIT). Patients and methods: A randomized controlled trial of MBSR with 120 DTC patients was performed. They were randomly assigned into the MBSR intervention group and usual care (UC) group. An 8-week MBSR program was administered to the MBSR group starting 8 weeks before RIT...
2019: Cancer Management and Research
Yang Yao, Jie Su, Lei Zhao, Na Luo, Lihui Long, Xingmei Zhu
Objective: NIMA-related kinase 2 (NEK2) has been reported to be overexpressed in various types of cancer and correlated with poor prognosis. The role(s) of NEK2 in cancer, however, is still uncertain. The aim of this study was to evaluate the prognostic value of NEK2 in human tumors. Methods: A comprehensive literature search was performed for PubMed, Embase, Web of Science, and CNKI databases, and eligible studies were included based on the inclusion and exclusion criteria...
2019: Cancer Management and Research
Huifei Zheng, Tengfei Chen, Chang Li, Chun Xu, Cheng Ding, Jun Chen, Sheng Ju, Zhiwei Zhang, Zhipan Liang, Zihan Cui, Jun Zhao
Purpose: Most recently, circular RNAs (circRNAs) were considered playing regulatory roles in tumor initiation and development. The specific function of circRNAs in hepatocellular carcinoma (HCC) remains unknown. This study was designed to detect specific roles of a circRNA hsa_circ_0079299 in HCC. Methods: The expression of hsa_circ_0079299 in HCC and tumor cell lines was detected using quantitative PCR (qPCR). Cell proliferation, migration, cell cycle and apoptosis after overexpression of the circRNA were measured using cell counting kit-8 (CCK8) assay, colony formation, 5-ethynyl-2'-deoxyuridine (EdU) assay, wound healing assay, transwell culture system and flow cytometry...
2019: Cancer Management and Research
Jie Xing, Li Min, Hao Zhang, Peng Li, Wei Li, Fujin Lv, Yongjun Wang, Zheng Zhang, Hengcun Li, Qingdong Guo, Siyi Wang, Yu Zhao, Junmin Wang, Xiaoyan Shi, Anxin Wang, Shengtao Zhu, Ming Ji, Yongdong Wu, Shutian Zhang
Background: Endoscopy is the main approach used for esophageal squamous cell carcinoma (ESCC) screening, especially in high-risk areas. However, little consensus has been achieved in recent ESCC screening programs, and endoscopists have selected patients only by age and family history. Patients and methods: To generate a proper strategy for selecting an eligible population for endoscopic screening based on demographic factors, lifestyle, and eating habits, a total of 7,830 residents in an area with a high risk of ESCC were recruited for this study...
2019: Cancer Management and Research
Sha Zhu, Lili Jiang, Liuyan Wang, Lingli Wang, Cong Zhang, Yu Ma, Tao Huang
Background: Resistance to mitoxantrone (MTX), an anthracenedione antineoplastic agent used in advanced and metastatic androgen-refractory prostate cancer (PCa), seriously limits therapeutic success. Methods: Xenografts from two human PCa cell lines (VCaP and CWR22) were established in male severe combined immunodeficiency mice, and MTX was administered, with or without concurrent castration, three times a week until tumors relapsed. Microarray technology was used to screen for differentially expressed genes (DEGs) in androgen-independent, MTX-resistant PCa xenografts...
2019: Cancer Management and Research
Min-Wei Zhou, Xiao-Yun Huang, Zong-You Chen, Zhen-Yang Li, Yi-Ming Zhou, Yi Yang, Zi-Hao Wang, Jian-Bin Xiang, Xiao-Dong Gu
Background: Some patients with low rectal cancer experience anorectal and urogenital dysfunctions after surgery, which can influence the long-term quality of life. In this study, we aimed to protect nerve function in such scenarios by performing intraoperative monitoring of pelvic autonomic nerves (IMPAN). Patients and methods: We retrospectively investigated a series of 87 patients undergoing laparoscopic low anterior resection of rectal cancer. Nerve-sparing was evaluated both visually and electrophysiologically...
2019: Cancer Management and Research
Sanziana Ri Schiopu, Gregor Habl, Matthias Haefner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
Purpose: Leptomeningeal metastasis (LM) is an increasingly common complication of late-stage systemic cancer, for which there is no standard treatment. We analyzed outcome and toxicity in patients with LM undergoing craniospinal irradiation via helical tomotherapy (HT-CSI) at our institution. Patients and methods: The charts of 15 patients diagnosed with LM and undergoing HT-CSI between 2006 and 2014 were retrospectively assessed. Main neoplasms included breast cancer, lung cancer, and lymphoma...
2019: Cancer Management and Research
Zhengyi Ruan, Xingyu Yang, Weiwei Cheng
Background: Although surgery, chemotherapy, and radiotherapy eliminate clinically apparent ovarian tumor, the 5-year survival rate is no more than 45%. Cancer stem cells (CSCs) have been identified for precaution of tumor metastasis and recurrence in many kinds of cancers including ovarian cancer. Aim: This study aims to explore the function of OCT4, a CSC marker, in ovarian cancer progression and to investigate its underlying mechanism. Materials and methods: By Hoechst side population (SP) technique, CSC-like SP cells from human ovarian cancer SKOV3 and A2780 cells were isolated and used for this study...
2019: Cancer Management and Research
Michele Ghidini, Claudio Pizzo, Andrea Botticelli, Jens Claus Hahne, Rodolfo Passalacqua, Gianluca Tomasello, Fausto Petrelli
Purpose: Incidence and mortality of biliary tract carcinoma (BTC) are increasing, especially in South America and Asia. Such a disease often bears a dismal prognosis because of diagnosis occurring at late stages and for the frequent relapses after surgery. The aims of this review were to summarize the state of the art of the treatment of BTC and give a view at possible future prospects linked with molecular profiling, immunotherapy, and targeted therapies. Design: We conducted a systematic literature search using MEDLINE and the 2018 ASCO Meeting abstract databases to identify published clinical trials, translational series, and meeting abstracts...
2019: Cancer Management and Research
Min Hong, Zuoyang Zhang, Qing Chen, Yanxia Lu, Jianming Zhang, Chun Lin, Fan Zhang, Wenjuan Zhang, Xiaomin Li, Wei Zhang, Xuenong Li
Background: Interferon regulatory factor 1 (IRF1) plays a role in the immune response, cellular necrosis, DNA damage, and DNA repair, offering an attractive target for anticancer treatment. However, little is known about the role of IRF1 in the regulation of CRC progression. Methods: Quantitative reverse transcription-PCR, Western blot, and immunohistochemistry were used to examine the expression level of IRF1; Cell Counting Kit-8, migration assay, and xenograft mouse models were used to examine the function of IRF1 in CRC cell lines; a ChIP assay was used to examine the binding between IRF1 and Ras association domain-containing protein 5 (RASSF5)...
2019: Cancer Management and Research
Tomas Buchler, Renata Chloupkova, Alexandr Poprach, Ondrej Fiala, Igor Kiss, Katerina Kopeckova, Ladislav Dusek, Veronika Veskrnova, Lubomir Slavicek, Milan Kohoutek, Jindrich Finek, Marek Svoboda, Lubos Petruzelka, Bohuslav Melichar
Purpose: Although inhibitors of vascular endothelial growth factor and inhibitors of epidermal growth factor receptor (EGFRi) are commonly used for the treatment of metastatic colorectal cancer (mCRC), the optimal sequencing of these agents is currently unclear. Methods: A national registry of targeted therapies was used to analyze baseline characteristics and outcomes of patients with mCRC and wild-type KRAS exon 2 status who received bevacizumab and EGFRi (cetuximab or panitumumab) as a part of first- and second-line treatment in either sequence...
2019: Cancer Management and Research
Li-Ping Chen, Hong Wang, Yi Zhang, Qiu-Xiang Chen, Tie-Su Lin, Zong-Qin Liu, Yang-Yang Zhou
Background: ceRNAs have emerged as pivotal players in the regulation of gene expression and play a crucial role in the physiology and development of various cancers. Nevertheless, the function and underlying mechanisms of ceRNAs in esophageal cancer (EC) are still largely unknown. Methods: In this study, profiles of DEmRNAs, DElncRNAs, and DEmiRNAs between normal and EC tumor tissue samples were obtained from the Cancer Genome Atlas database using the DESeq package in R by setting the adjusted P <0...
2019: Cancer Management and Research
Dongxiao Zhang, Yinjun Dong, Xiubin Sun, Shuanghu Yuan, Jinming Yu
Background: For the melanoma patients who are with the primary tumor and metastatic disease concurrently (the newly diagnosed metastatic patients), the effect of primary tumor surgery on survival has never been discussed. Objective: We sought to estimate this effect based on data from the Surveillance, Epidemiology, and End Results database. Patients and methods: We identified patients with newly diagnosed metastatic melanoma from 2004 to 2015...
2019: Cancer Management and Research
Wanli Yang, Jiaojiao Ma, Wei Zhou, Zichao Li, Xin Zhou, Bo Cao, Yujie Zhang, Jinqiang Liu, Zhiping Yang, Hongwei Zhang, Qingchuan Zhao, Liu Hong, Daiming Fan
Background: Colon cancer is one of the leading malignant neoplasms worldwide. Until now, the concrete mechanisms of colonic cancerogenesis are largely unknown; identification of driven genes and pathways is, therefore, of great importance for monitoring and conquering this disease. This study aims to explore the potential biomarkers and therapeutic targets for colon cancer treatment. Methods: The gene expression profile of GSE44076 from Gene Expression Omnibus database, including 98 primary colon cancers and 98 normal distant colon mucosa, was deeply analyzed...
2019: Cancer Management and Research
Andreas Schicho, Christoph Niessen, Michael Haimerl, Isabel Wiesinger, Christian Stroszczynski, Lukas P Beyer, Philipp Wiggermann
Background: For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods: This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results: Of the 24 included patients, 18 (75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37...
2019: Cancer Management and Research
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