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Cancer Management and Research

Jinna Wu, Huanhuan Sun, Shuncong Wang, Yan Yan, Fengze Sun, Yushi Li, Guangwei Yang, Haiqing Ma
Objective: Squamous cervical cancer (SCC), the predominant histological type, represents approximately 75-80% of all cervical cancers. Although the overall incidence of cervical cancer has declined worldwide, the data describing the changes in the incidence and long-term survival in SCC remain limited. Methods: The data were extracted from Surveillance, Epidemiology, and End Results (SEER) registries for an evaluation of the changes in the incidence and survival associated with SCC during 1983-2012...
2018: Cancer Management and Research
Chuanben Chen, Zhaodong Fei, Chaoxiong Huang, Jianming Ding, Lisha Chen
Background: The prognostic value of primary tumor volume (TV) in nasopharyngeal carcinoma (NPC) has been confirmed. However, studies of the prognosis value of tumor burden, including TV and nodal volume (NV), have been relatively infrequent. Therefore, the aim of this study was to evaluate the prognostic value of tumor burden in NPC patients treated with intensity-modulated radiotherapy. Methods: Receiver operating characteristics curves were generated to determine rational cutoff points for TV and NV...
2018: Cancer Management and Research
Bin Liu, Xiaojing Xing, Xiang Li, Qianxue Guo, Tonghong Xu, Ke Xu
Purpose: Zinc finger protein 259 (ZNF259), also known as ZPR1, is a zinc finger-containing protein that can bind the intracellular tyrosine kinase domain of EGFR. At present, our knowledge on ZNF259 in cancers is limited. Here, we aimed to explore the biological functions of ZNF259 in breast cancer and reveal their mechanisms. Patients and methods: The expression of ZNF259 was measured in 133 cases of breast cancer by immunohistochemistry. The online database Kaplan-Meier (KM) Plotter Online Tool was used to analyze the relationship between ZNF259 expression and breast cancer patient survival prognosis...
2018: Cancer Management and Research
Xiaoying Li, Xin Hong, Xianshu Gao, Xiaobin Gu, Wei Xiong, Jing Zhao, Hongliang Yu, Ming Cui, Mu Xie, Yun Bai, Shaoqian Sun
Purpose: In our previous study, we found that AKR1C3 was a radioresistance gene in KY170R cells. Downregulating the expression of AKR1C3 could enhance the radiosensitivity of esophageal carcinoma cells. In this study, we investigated whether methyl jasmonate (MeJ), an inhibitor of Aldo-keto reductase family1 member C3 ( AKR1C3 ), could overcome radiation resistance in AKR1C3 highly expressed cells. Patients and methods: We used clone formation assays to detect radiosensitivity effects...
2018: Cancer Management and Research
Zhigang Cui, Min Gao, Zhihua Yin, Lei Yan, Lei Cui
Objective: To explore the relationship between single-nucleotide polymorphisms (SNPs) in one of the long noncoding RNA (lncRNA), cancer susceptibility candidate 8 ( CASC8 ) gene and the risk of cancer. Materials and methods: A meta-analysis was conducted to summarize the relationship between common SNPs (rs10505477 and rs7837328) in the lncRNA CASC8 gene and the risk of cancer. The relevant references were retrieved from several authoritative databases. Rigorous inclusion and exclusion criteria were adopted to ensure the credibility of the results...
2018: Cancer Management and Research
Dongyang Li, Hang Lv, Xuanyu Hao, Bin Hu, Yongsheng Song
Background: Many studies have evaluated the relationship between alkaline phosphatase (ALP) and the prognosis for prostate cancer (PCa). But they have not reached a widespread consensus yet. Therefore, we completed a meta-analysis to ascertain the significance of ALP and the prognosis for PCa. Methods: A literature search was performed in the PubMed, Embase, and Web of Science databases. HRs concerning overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS) were extracted to evaluate the impacts of ALP on the prognosis for PCa...
2018: Cancer Management and Research
Evgenii Belykh, Arpan A Patel, Eric J Miller, Baran Bozkurt, Kaan Yağmurlu, Eric C Woolf, Adrienne C Scheck, Jennifer M Eschbacher, Peter Nakaji, Mark C Preul
Background: Confocal laser endomicroscopy (CLE) is used during fluorescence-guided brain tumor surgery for intraoperative microscopy of tumor tissue with cellular resolution. CLE could augment and expedite intraoperative decision-making and potentially aid in diagnosis and removal of tumor tissue. Objective: To describe an extension of CLE imaging modality that produces Z-stack images and three-dimensional (3D) pseudocolored volumetric images. Materials and methods: Hand-held probe-based CLE was used to collect images from GL261-luc2 gliomas in C57BL/6 mice and from human brain tumor biopsies...
2018: Cancer Management and Research
Jianyuan Song, Xiaoxue Huang, Zhuhong Chen, Mingqiu Chen, Qingliang Lin, Anchuan Li, Yuangui Chen, Benhua Xu
Objective: To explore the value of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in predicting downstaging to stage 0-I cancer after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer. Materials and methods: We respectively investigated pretreatment CEA, pretreatment CA19-9, posttreatment CEA, posttreatment CA19-9, pre-post-CA19-9 ratio, and pre-post-CEA ratio in 674 patients with locally advanced rectal cancer receiving nCRT and determined the patients' thresholds by using the receiver operating characteristic curve analysis...
2018: Cancer Management and Research
Andrea Rocca, Roberta Maltoni, Sara Bravaccini, Caterina Donati, Daniele Andreis
Fulvestrant is the first selective estrogen receptor (ER) downregulator available in clinical practice. It is a pure antiestrogen with no agonistic effects, leading to degradation of ER alpha, with activity in tamoxifen-resistant breast cancer (BC) models. Pharmacokinetic and pharmacodynamic studies and several postmarketing clinical trials led to the definition of the optimal dose at 500 mg intramuscularly on days 1, 15, and 29 and then every 28 days. Targeting ER alpha, fulvestrant is a cornerstone of treatment in luminal BCs, whose growth is largely driven by the ER pathway...
2018: Cancer Management and Research
Xuanxuan Dai, Junru Zhang, Guilong Guo, Yuepiao Cai, Ri Cui, Changtian Yin, Weidong Liu, Rajamanickam Vinothkumar, Tingting Zhang, Guang Liang, Xiaohua Zhang
Introduction: Targeted therapies using epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC) patients harboring EGFR mutations, leading to the approval of gefitinib and erlotinib as standard first-line clinical treatment. Inevitably, a considerable proportion of patients develop resistance to EGFR-TKIs due to the acquisition of secondary mutations within EGFR. Therefore, alternative strategies to target NSCLC are desperately needed...
2018: Cancer Management and Research
Zhuo Chen, Zhengkui Jiang, Wenzhou Zhang, Baoxia He
Background: The application of the oral targeted therapeutic agent sorafenib provides new hope for patients suffering from advanced stages of hepatocellular carcinoma (HCC), but the prognosis of such patients remains poor due to the rapid development of the multidrug resistance process in cancer pathogenesis. The present work evaluated whether copine-III, a novel cancer regulator encoded by the CPNE3 gene, would be a potential indicator of sorafenib resistance in HCC treatment. Materials and methods: The endogenous expression of copine-III in clinical specimens was examined by quantitative polymerase chain reaction...
2018: Cancer Management and Research
E Du, Chao Lu, Fei Sheng, Changying Li, Hong Li, Na Ding, Yue Chen, Ting Zhang, Kuo Yang, Yong Xu
Background: Dysfunction of primary cilia (PC), which could influence cell cycle and modulate cilia-related signaling transduction, has been reported in several cancers. However, there is no evidence of their function in bladder cancer (BLCA). This study was performed to investigate the presence of PC in BLCA and to explore the potential molecular mechanisms underlying the PC in BLCA. Patients and methods: The presence of PC was assessed in BLCA and adjacent non-cancerous tissues...
2018: Cancer Management and Research
Jie Ruan, Peipei Xu, Wei Fan, Qiaoling Deng, Mingxia Yu
Epigenetic alteration of P16INK4a is conventionally thought to induce the initiation of carcinoma. However, the role of P16INK4a methylation in ovarian cancer still remains controversial. Therefore, we performed a meta-analysis to further elucidate the relationship between P16INK4a promoter methylation and ovarian cancer. A total of 24 studies, including 20 on risk, 10 on clinicopathological features, and 3 on prognosis, were included in our meta-analysis. Our results indicated that the frequency of P16INK4a methylation in cancer tissues was significantly higher than normal tissues and low malignant potential tumor tissues (odds ratio [OR] =5...
2018: Cancer Management and Research
Yi Zhang, Xu Zhang
Background: The aspartate aminotransferase-to-platelet ratio index (APRI) has been correlated with clinical outcome in patients with hepatocellular carcinoma (HCC), but controversial results were obtained with previous studies. This study was aimed to evaluate the prognostic value of the APRI in patients with HCC. Materials and methods: A literature survey was conducted by searching PubMed, Web of Science, Cochrane library, Embase, Wanfang, and National Knowledge Infrastructure for publications released prior to March 1, 2018...
2018: Cancer Management and Research
Claudia Sew Schuurhuizen, Henk Mw Verheul, Annemarie Mj Braamse, Laurien M Buffart, Haiko J Bloemendal, Joost Dekker, Inge Rhm Konings
Background: Studies evaluating new systemic agents tend to report severe toxicities only, while the cumulative effect of multiple lower grade adverse events (AEs) may have an additional negative impact on patient quality of life (QOL). In the current observational cohort study, we evaluated whether, in patients with metastatic colorectal cancer receiving first-line chemotherapy, cumulative toxicity comprising all grades of AEs is more predictive for QOL than cumulative toxicity due to only high-grade AEs...
2018: Cancer Management and Research
Xuechao Liu, Zhimin Liu, Enzi Lin, Yingbo Chen, Xiaowei Sun, Zhiwei Zhou
Background: Recent studies have revealed that preoperative fibrinogen and the neutrophil-lymphocyte ratio (NLR) are associated with poor outcome in gastric cancer (GC). We aimed to evaluate whether the fibrinogen and the NLR score had a consistent prognostic value for resectable GC. Methods: We analyzed 1,293 consecutive patients who underwent curative surgery for GC. The F-NLR score was 2 for patients with hyperfibrinogenemia (>400 mg/dL) and elevated NLR (≥5...
2018: Cancer Management and Research
Kui Liu, Meng Jin, Li Xiao, Huiguo Liu, Shuang Wei
Introduction: Glutathione peroxidases (GPxs) constitutes an enzyme family which has the ability to reduce free hydrogen peroxide to water and lipid hydroperoxides to their corresponding alcohols, and its main biological roles are to protect organisms from oxidative stress-induced damage. GPxs include eight members in different tissues of the body, and they play essential roles in carcinogenesis. However, the prognostic value of individual GPx in non-small cell lung cancer (NSCLC) remains elusive...
2018: Cancer Management and Research
Qiang-Hua Zhou, Chuang-Zhong Deng, Jie-Ping Chen, Kang-Bo Huang, Ting-Yu Liu, Kai Yao, Zhuo-Wei Liu, Zi-Ke Qin, Yong-Hong Li, Sheng-Jie Guo, Yun-Lin Ye, Fang-Jian Zhou, Wenlin Huang, Ran-Yi Liu, Hui Han
Purpose: Molecular biomarkers, especially serologic factors, have been widely applied in cancer diagnosis and patient follow-up. However, there are few valuable prognostic factors in penile squamous cell carcinoma (PSCC). Here, the authors investigated whether laminin gamma 2 (LAMC2) expression, especially serum LAMC2 (sLAMC2) level, was a suitable prognostic factor that could aid in the prediction of survival in PSCC. Patients and methods: This study included 114 PSCC patients...
2018: Cancer Management and Research
Jumpei Asakawa, Taro Iguchi, Satoshi Tamada, Noriko Ninomiya, Minoru Kato, Takeshi Yamasaki, Tatsuya Nakatani
Purpose: To compare treatment outcomes, more specifically patency rate, of polymeric and metallic stents for malignant ureteral obstruction. Patients and methods: Between August 2007 and September 2017, we retrospectively analyzed the data of 92 patients (126 ureters) having a diagnosis of malignant extrinsic ureteral obstruction treated with indwelling ureteral stents (polymeric and full-length metallic stents). Of these patients, 35 (54 ureters) were treated with polymeric stents and 57 (72 ureters) with a Resonance® metallic stent...
2018: Cancer Management and Research
Shuchen Chen, Hao Qiu, Chao Liu, Yafeng Wang, Weifeng Tang, Mingqiang Kang
Background: IGF2BP2 and IGFBP3 polymorphisms may be associated with cancer risk. Methods: With an aim to determine the association of variations in IGF2BP2 and IGFBP3 genes with risk of non-small-cell lung cancer (NSCLC), IGF2BP2 rs1470579 A>C, rs4402960 G>T and IGFBP3 rs2270628 C>T, rs3110697 G>A, and rs6953668 G>A polymorphisms were selected and genotyped in 521 NSCLC patients and 1,030 controls. Results: We found that there was no difference in IGF2BP2 and IGFBP3 genotype distribution among the NSCLC patients and controls...
2018: Cancer Management and Research
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