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Cancer Management and Research

Wei-Fu Lv, Kai-Cai Liu, Dong Lu, Chun-Ze Zhou, De-Lei Cheng, Jing-Kun Xiao, Xing-Ming Zhang, Zheng-Feng Zhang
Objectives: To explore the efficacy and influencing factors of transarterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC) combined with portal vein tumor thrombosis (PVTT). Materials and methods: The clinical data of 3,126 consecutive patients who suffered from advanced HCC and underwent TACE were retrospectively analyzed. A total of 685 patients had a combination of HCC and PVTT. Of these patients, 475 were treated with TACE (Group A) and 210 were given a supportive care (Group B)...
2018: Cancer Management and Research
Céline Montavon Sartorius, Uzma Mirza, Andreas Schötzau, Gillian Mackay, Daniel Fink, Neville F Hacker, Viola Heinzelmann-Schwarz
Purpose: The stage of disease is one of the strongest prognostic factors in epithelial ovarian cancer. The International Federation of Gynecology and Obstetrics (FIGO) classification was revised in 2013; stage IC was subdivided into IC1 (intraoperative surgical spill), IC2 (capsule rupture before surgery or tumor on surface), and IC3 (positive peritoneal washing or ascites). Our aim was to compare the outcome of patients in the new FIGO stage I subgroups, as this might influence adjuvant therapy decisions...
2018: Cancer Management and Research
Yi Zhang, Lijuan Wang, Shibu Lin, Rong Wang
Background: Emerging studies reported that preoperative albumin-to-globulin ratio (AGR) correlated with tumor progression and prognosis in several types of cancer. The aim of this study was to systematically explore the association between preoperative AGR and clinical outcomes in cancers of the urinary system. Methods: Relevant articles were searched in PubMed, Embase and Web of Science by two independent investigators from inception to June 1, 2018. Eligible studies were selected based on predetermined selection criteria...
2018: Cancer Management and Research
Zafer Orkun Toktas, Baran Yilmaz, Murat Şakir Ekşi, Lei Wang, Akin Akakin, Yasin Yener, Murat Konakcı, Emre Ayan, Turker Kılıc, Deniz Konya, Yang D Teng
Purpose: To date, application of intraoperative magnetic resonance imaging (ioMRI) to enhance surgical quality for spinal intramedullary neoplastic lesions has been rarely reported. Moreover, in developing countries or regions, ioMRI accessibility remains very limited. This report describes a technology design of high-field ioMRI accessible for multioperation rooms via a case presentation of an imaging-assisted surgical excision of human cervical spinal cord diffuse glioma. Patient and methods: The patient was a 44-year-old woman with symptomatic and progressive C2-5 intramedullary diffuse glioma (IDG)...
2018: Cancer Management and Research
Zhe-Nan Zhang, Cheng Luo, Ben Xu, Hai-Feng Song, Bing-Lei Ma, Qian Zhang
Purpose: To study the association between the preoperative PROSTATE scoring system and the prediction of biochemical recurrence (BCR) risk, after radical prostatectomy (RP) in prostate cancer patients. Patients and methods: A total of 340 patients who underwent a laparoscopic radical prostatectomy in Peking University First Hospital between November 2007 and March 2016 were included in the study. The preoperative PROSTATE scoring system was measured and calculated...
2018: Cancer Management and Research
Rama Jayaraj, Chellan Kumarasamy
No abstract text is available yet for this article.
2018: Cancer Management and Research
Shengquan Yang, Jian Chen, Yang Yu, Deli Li, Mengyuan Huang, Li Yuan, Guoyong Yin
Background: Long intergenic non-protein coding RNA, a regulator of reprogramming (ROR), has been found to play an oncogene role in various human malignant tumors. This meta-analysis aimed to synthesize available data to verify the association between clinical prognosis value and ROR expression level. Materials and methods: We performed a systematic search by using PubMed (Medline), Embase, Cochrane Library, ScienceDirect, Springer, and ISI Web of Knowledge from inception to November 15, 2017...
2018: Cancer Management and Research
Zhen Zhang, Fulin Chen, Lijun Shang
In recent years, the reports on using nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer prevention and treatment have been on the rise. In 2017, the US Preventive Services Working Group issued primary prevention guidelines on the use of NSAIDs, especially aspirin, for cardiovascular disease and colorectal cancer, and formally established the role and status of aspirin in cancer prevention. However, the mechanism of NSAIDs on preventing cancer is still not clear. In this paper, the progress of the application of NSAIDs, especially aspirin, in the prevention and treatment of tumors in recent years is summarized, and new ideas and directions for the follow-up study are also discussed...
2018: Cancer Management and Research
Hong Zheng, Chao Zhou, Xiao Lu, Quanxing Liu, Minqiang Liu, Guoqing Chen, Weigang Chen, Shuai Wang, Yuan Qiu
Background: Protein/nucleic acid deglycase (DJ-1) and hypoxia-inducible factor-1α (HIF-1α) play significant roles in the progression of various types of cancer and are associated with the phosphatidylinositol 3-kinase (PI3K) pathway. However, their functions in colorectal cancer (CRC) have not been identified. The aim of this study was to analyze the putative signaling pathway encompassing DJ-1, PI3K, and HIF-1α in a series of CRC tissues and cell lines. Purpose: This study aimed at exploring the expression status of DJ-1 in colon cancer and its role in survival of cancer cell lines...
2018: Cancer Management and Research
Shanbiao Hu, Ling Li, Wei Huang, Jie Liu, Gongbin Lan, Shaojie Yu, Longkai Peng, Xubiao Xie, Luoyan Yang, Yeqi Nian, Yinhuai Wang
Background: Aberrant expression of CAV3.1, one of T-type Ca2+ channels, is reported to exert important functions in pathological processes, including carcinogenesis. However, its expression pattern and function in prostate cancer (PCa) remains unclear. Materials and methods: The expression pattern of CAV3.1 was analyzed in multiple ways, including online analysis in Oncomine database, experimental analyses in cell lines, and collected clinical specimens using immunohistochemistry, quantitative reverse transcription polymerase chain reaction, and Western blot...
2018: Cancer Management and Research
Kashyap B Patel, Luiz H Arantes, Wing Yu Tang, Selwyn Fung
Biopharmaceuticals (biologics) represent one of the fastest growing sectors of cancer treatment. They are recommended for treating underlying cancer and as supportive care for management of treatment side effects. Given the high costs of cancer care and the need to balance health care provision and associated budgets, patient access and value are the subject of discussion and debate in the USA and globally. As the costs of biologics are high, biosimilars offer the potential of greater choice and value, increased patient access to treatment, and the potential for improved outcomes...
2018: Cancer Management and Research
Changjiang Sun, Xizhi Zhang, Yong Chen, Qingqing Jia, Jianqi Yang, Yusheng Shu
Background: A number of studies have indicated that expression of miRNA-365 (miR-365) is suppressed in various cancers, suggesting its cancer-suppressive role. In the present investigation, we evaluated the regulation and character of miR-365 in human esophageal squamous cell carcinoma (ESCC). Patients and methods: The tumor tissues and adjacent nontumor tissue samples were collected from 30 patients having ESCC, and the expression levels of miR-365 were studied by quantitative real-time polymerase chain reaction (PCR)...
2018: Cancer Management and Research
Jingping Qiu, Shi Jia, Guang Li
Background: Choriocarcinoma usually occurs in females and sometimes occurs in the testicles of males. Extragonadal choriocarcinoma in males was previously described in case reports, and our understanding of this type of cancer has remained limited. The purpose of this study was to explore the incidence, treatment and prognostic factors of extragonadal choriocarcinoma in males. Materials and methods: Two cohorts were identified from the Surveillance, Epidemiology, and End Results (SEER) Program by histology, tumor site and sex...
2018: Cancer Management and Research
Azizi A Seixas, Lloyd Gyamfi, Valerie Newsome, Gabrielle Ranger-Murdock, Mark Butler, Diana Margot Rosenthal, Ferdinand Zizi, Irini Youssef, Samy I McFarlane, Girardin Jean-Louis
Background: Growing evidence suggests that cancer and diabetes may share common risk factors such as age, race/ethnicity, obesity, insulin resistance, sedentary lifestyle, smoking, and alcohol consumption. However, little is known about how habitual sleep duration (a known cardiometabolic risk factor) may affect the relationship between cancer and diabetes. The aim of this study was to investigate whether sleep duration moderated the relationship between history of cancer and diabetes...
2018: Cancer Management and Research
Esam-Rajab Mahroug, Candice Sher-Locketz, Minodora-Silvia Desmirean, Emmanuel-Akinola Abayomi, Ciprian Tomuleasa, Ravnit Grewal
Introduction: Castleman's disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with an incompletely understood pathogenesis and variable clinical behavior. This study aimed to determine the incidence of CD diagnosis over an 11-year period. Additionally, the study aimed to describe the demographic, laboratory, and pathological features of CD. Methods: This is a retrospective study where the demographic and laboratory data were retrieved from the Tygerberg Academic Hospital (TAH) patient electronic records and Tygerberg Lymphoma Study Group (TLSG) and statistical analysis performed on the patients diagnosed with CD...
2018: Cancer Management and Research
Yan Chen, Lin Zhang, Lei Liu, Shixiu Sun, Xuyang Zhao, Yueyuan Wang, Yujie Zhang, Jun Du, Luo Gu
Background: Runt-related transcription factor 1 (RUNX1), an essential regulator of hematopoiesis, is overexpressed in patients with nonsmall-cell lung cancer (NSCLC) and is correlated with enhanced metastatic ability. Ras-interacting protein 1 ( Rasip1 ), a potential oncogene, is required for blood vessel formation, and recently, it has been shown that Rasip1 is widely expressed in NSCLC patients. We noticed that Rasip1 promoter contains several potential RUNX1-binding sequences. However, the relationship between Rasip1 and RUNX1 in NSCLC is still unknown...
2018: Cancer Management and Research
Shu-Wei Chen, Quan Zhang, Zhu-Ming Guo, Wen-Kuan Chen, Wei-Wei Liu, Yan-Feng Chen, Qiu-Li Li, Xue-Kui Liu, Hao Li, Dian Ou-Yang, Wei-Chao Chen, Xiao-Yan Fu, Xi-Di Wang, An-Kui Yang, Jin-Xin Bei, Ming Song
Background: Global data demonstrate minimal improvement in the survival rate for oral cavity cancer (OCC) patients. We wished to know whether or not clinical features and survival rate have changed over time for OCC patients receiving initial treatment and follow-up at a large cancer center in China. Methods: Clinical features and survival data were collected on patients diagnosed during the successive decades of 1960-1969 (n=253), 1970-1979 (n=497), 1980-1989 (n= 659), 1990-1999 (n=793), and 2000-2009 (n=1,160) at the Sun Yat-sen University Cancer Center...
2018: Cancer Management and Research
Xandra García-González, Sara López-Tarruella, María Isabel García, Eva González-Haba, Carolina Blanco, Sara Salvador-Martin, Yolanda Jerez, Fabienne Thomas, María Jarama, María Sanjurjo Sáez, Miguel Martín, Luis Andrés López-Fernández
Severe, life-threatening adverse reactions to capecitabine sometimes occur in the treatment of solid tumors. Screening for dihydropyrimidine dehydrogenase (DPYD) deficiency is encouraged before start of treatment, but the genetic variants that are commonly analyzed often fail to explain toxicities seen in clinical practice. Here we describe the case of a 79-year-old Caucasian female with breast cancer who presented with life-threatening, rapidly increasing toxicity after 1 week of treatment with capecitabine and for whom routine genetic DPYD test resulted negative...
2018: Cancer Management and Research
Wen-Wen Zhang, San-Gang Wu, Yi-Hong Ling, Jia-Yuan Sun, Zhi-Qing Long, Xin Hua, Yong Dong, Feng-Yan Li, Zhen-Yu He, Huan-Xin Lin
Introduction: We aimed to evaluate the clinicopathologic characteristics and clinical outcomes of the mixed type versus the pure type of tubular carcinoma (TC) of the breast in a retrospective cohort study. Materials and methods: Patients were categorized into the following three groups: patients with pure TC of the breast (the PTC group), patients with TC and carcinoma in situ of the breast (the TC-CIS group), and patients with TC and other invasive carcinomas of the breast (the TC-IC group)...
2018: Cancer Management and Research
Mengting Tong, Jing Wang, Wenting He, Yanling Wang, Hongming Pan, Da Li, Hongliang Zhang
The development of immune checkpoint inhibitors represented by PD-1 and PD-L1 has provided new hope for the treatment of advanced cancer patients. However, there are no effective predictive biomarkers, which have caused many limitations to the clinical application of immune checkpoint inhibitors. This paper combines recent domestic and international research as well as clinical trials to discuss the current status and progress of PD-L1 expression as a biomarker for tumor immunotherapy and also to discuss whether tumor mutation burden, tumor-infiltrating lymphocytes, tumor cell gene expression profiling, or peripheral blood markers would be a potential predictive biomarker for novel tumor immunotherapy...
2018: Cancer Management and Research
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