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Cancer Management and Research

Chengping Hu, Juan Jiang, Yuanyuan Li, Chunfang Zhang, Weixing Zhang, Haihe Jiang, Yang Gao, Wei Zhuang, Kaibo Lei, Yong Tang, Rongjun Wan
Background: Tumor cell dissemination after needle biopsy has been reported in a variety of malignancies, including non-small-cell lung cancer (NSCLC). However, there is little clinical evidence in regard to whether preoperative biopsy increases the risk of recurrence in completely resected NSCLC. Patients and methods: A total of 322 patients diagnosed as pathological stage I NSCLC using intraoperative biopsy (IOB) (control group), preoperative percutaneous needle biopsy (PNB) or bronchoscopic biopsy were included in this study...
2018: Cancer Management and Research
Liang Zhao, Haojun Chen, Bin Hu, Huan Zhang, Qin Lin
Purpose: To investigate the association of pretreatment Ki67 expression and the derived neutrophil-lymphocyte ratio (dNLR) with clinical outcomes in nasopharyngeal carcinoma (NPC). Patients and methods: For the study, 46 patients diagnosed with NPC at our hospital were recruited between April 2013 and December 2015. All patients were histologically confirmed to have non-keratinizing undifferentiated NPC. The expression of Ki67 proteins in NPC tissue was analyzed immunohistochemically, and the dNLR was assessed in the peripheral blood, both before treatment...
2018: Cancer Management and Research
Lai Wang, Chien-Shan Cheng, Lianyu Chen, Zhen Chen
Purpose: In the past 20 years, surgical resection has been a secure and applicable procedure for pancreatic cancer (PC), but it remains controversial for stage III PC with data evaluating its efficacy mostly derived from small randomized trials. Hence, we designed this study to further evaluate its benefit using surveillance, epidemiology, and end results dataset. Patients and methods: Patients with stage III PC were identified in the surveillance, epidemiology, and end results registries from 2004 to 2014...
2018: Cancer Management and Research
Yi Luo, Fan Tang, Yitian Wang, Yong Zhou, Li Min, Wenli Zhang, Rui Shi, Hong Duan, Chongqi Tu
Background: Giant cell tumor (GCT) of bone is an intermittent and locally aggressive tumor with increasing pulmonary metastatic potential. In this study, we evaluated the interim clinical outcome of denosumab in patients with pulmonary metastatic GCT. Materials and methods: We retrospectively reviewed seven patients with pulmonary metastatic GCT who received denosumab treatment after local tumor surgery during January 2014 and July 2016. Denosumab treatment for all patients lasted for at least 12 months...
2018: Cancer Management and Research
Yoshinori Higuchi, Masaaki Yamamoto, Toru Serizawa, Hitoshi Aiyama, Yasunori Sato, Bierta E Barfod
Historically, whole brain radiotherapy was administered to most patients with brain metastases. However, over the past three decades, stereotactic radiosurgery (SRS), targeted at individual cranial lesions, has been accepted widely. In this study, based on the authors' experiences along with published data, recent trends in SRS for brain metastases are discussed. This article focuses on the following issues: 1) How many tumors can or should be treated with SRS? 2) Two-/three-staged SRS for relatively large tumors, 3) post- or preoperative SRS, and 4) repeat SRS...
2018: Cancer Management and Research
Xiao Li, Qi Zhao, Bang An, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin
Purpose: The purpose of this study was to determine whether macroscopic growth patterns had an impact on the prognosis of colorectal cancer (CRC) patients with different tumor-node-metastasis (TNM) stages and responses to chemotherapy in stage III patients. Patients and methods: We retrospectively recruited 4,080 stage I-III CRC patients who underwent curative resection at Shandong Provincial Hospital affiliated to Shandong University. All patients were grouped by macroscopic growth patterns (expansive, infiltrative and ulcerative subtypes), and stage III patients were further divided into chemotherapy and nonchemotherapy groups...
2018: Cancer Management and Research
Mitsuyoshi Okazaki, Sachio Fushida, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Itasu Ninomiya, Shinichi Harada, Tetsuo Ohta
Background: In patients with gastric cancer, one of the greatest obstacles to effective chemotherapy is the development of chemoresistance. It has been previously reported that hypoxia-inducible factor-1 alpha (HIF-1α) is associated with acquisition of chemoresistance, and more recent studies have also noted an association of pyruvate kinase muscle 1 (PKM1) and chemoresistance. The purpose of this study was to identify the effect of HIF-1α and PKM1 expression on the development of acquired chemoresistance using a paclitaxel (PTX)-resistant gastric cancer cell line...
2018: Cancer Management and Research
Binbin Yu, Xiaodong Zhu, Zhongguo Liang, Yongchu Sun, Wei Zhao, Kaihua Chen
Background: We undertook a meta-analysis to evaluate the clinical usefulness of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) for the detection of distant metastases in patients with non-small cell lung cancer (NSCLC) at initial staging. Materials and methods: All topic-related studies were comprehensively searched in the MEDLINE and Embase databases. We obtained the summary estimates and constructed the summary receiver operating characteristic curve for 18 F-FDG PET/CT using the bivariate regression model...
2018: Cancer Management and Research
James Gilmore, Steven D'Amato, Niesha Griffith, Lee Schwartzberg
Purpose: To discuss new therapeutic strategies for chemotherapy-induced nausea and vomiting (CINV) involving 5-hydroxytryptamine type 3 (5HT3 )-receptor antagonists (RAs). Summary: CINV remains poorly controlled in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC); nausea and delayed-phase CINV (24-120 hours after chemotherapy) are the most difficult to control. National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO) antiemesis-guideline recommendations for HEC include a four-drug regimen (5HT3 RA, neurokinin 1 [NK1 ] RA, dexamethasone, and olanzapine)...
2018: Cancer Management and Research
Pengtao Yang, Meng Wang, Tian Tian, Yanjing Feng, Yi Zheng, Tielin Yang, Hongtao Li, Shuai Lin, Peng Xu, Yujiao Deng, Qian Hao, Na Li, Feng Guan, Zhijun Dai
Introduction: CYP17 is the second most important enzyme in estradiol synthesis. Epidemiological studies have shown the associations between CYP17 polymorphisms and cancer risk. We conducted a case-control study to evaluate the relationship between CYP17 polymorphisms (rs743572 and rs2486758) and breast cancer (BC) risk. Patients and methods: This case-control study included 560 BC patients and 583 age-matched healthy controls from Northwest China. Two polymorphisms (rs743572 and rs2486758) of CYP17 were genotyped by using Sequenom MassARRAY...
2018: Cancer Management and Research
Wei Chen, Jia You, Qi Zheng, Yue-Yong Zhu
Introduction: Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play important roles in the progression of hepatocellular carcinoma (HCC) by regulating gene expression. However, the identification of functional lncRNAs in HCC remains insufficient. Our study aimed to investigate the function of lncRNA OGFRP1, which has not been functionally researched before, in Hep3B and HepG2 cells. Methods: lncRNA OGFRP1 in HCC cells was down-regulated by using RNAi technology...
2018: Cancer Management and Research
Haixia Zhou, Zhenjian Zhuo, Shanshan Chen, Jie Zhao, Yixiao Mo, Jiao Zhang, Jing He, Jichen Ruan
Introduction: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between MYCN gene single-nucleotide polymorphisms (SNPs) and neuroblastoma risk. Patients and methods: To investigate the contribution of MYCN gene polymorphisms to neuroblastoma risk, we performed a 3-center case-control study by genotyping 4 SNPs in the MYCN gene from 429 cases and 884 controls...
2018: Cancer Management and Research
HuanHuan Guo, Shuo Huang, Shuang Li, Hui Yu, ShiXiong Wu, XuHong Zhou
Background and objective: Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy. Despite recent advances in treatment, the prognosis, particularly for those at the advanced stages, remains poor. Moreover, the underlying genetic and molecular events have remained obscure so far. Recently, increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) could act as either oncogenes or tumor suppressor genes in various cancers depending on their targets. And some lncRNAs have been shown to be aberrantly expressed in NPC...
2018: Cancer Management and Research
Ling Dai, Guangdong Pan, Xiaojia Liu, Jiang Huang, Zhiqing Jiang, Xiaobao Zhu, Xinli Gan, Qing Xu, Ning Tan
Purpose: The identification of prognostic markers for colorectal cancer (CRC) is needed for clinical practice. Fructose-bisphosphate aldolase A (ALDOA) and DEAD box p68 RNA helicase (DDX5) are commonly overexpressed in cancer and correlate with tumorigenesis. However, association between expression of ALDOA and DDX5, and CRC outcome has not been reported. Patients and methods: We used 141 formalin-fixed paraffin-embedded (FFPE) specimens collected from 105 patients with CRC treated at the Affiliated Hospital of Guilin Medical University and the People's Hospital of Liuzhou...
2018: Cancer Management and Research
Yong-Bo Xiao, Shao-Hang Cai, Li-Li Liu, Xia Yang, Jing-Ping Yun
Introduction: Hepatocellular carcinoma (HCC) has a close relationship with lipid metabolism. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. Methods: A total of 804 HCC specimens were collected to construct a tissue microarray and for immunohistochemical analysis. The relationship between PPARα expression and clinical features of HCC patients was analyzed...
2018: Cancer Management and Research
Chao Liu, Bing Sun, Bin Xu, Xiangying Meng, Lan Li, Yang Cong, Jiannan Liu, Qian Wang, Liang Xuan, Qibin Song, Shikai Wu
Introduction: Programmed cell death protein 1 (PD-1), an immune checkpoint molecule, has recently been recognized as a predictive and prognostic biomarker in several malignant tumors, but its diagnostic value remains largely unknown. We aimed to investigate the differential diagnostic efficiency of PD-1 and other immune molecules and propose a panel of immune molecules combined with cancer antigen 15-3 (CA15-3) to distinguish breast cancer (BC) from benign breast disease (BBD). Patients and methods: Ninety-one eligible BC patients and 31 BBD patients were enrolled...
2018: Cancer Management and Research
Yaqi Wang, Lifeng Yang, Menglong Zhou, Lijun Shen, Jing Zhang, Weijuan Deng, Liping Liang, Ran Hu, Wang Yang, Ye Yao, Zhen Zhang
Purpose: To investigate whether young patients exhibit different characteristics and survival according to tumor location and stage using data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients and methods: Young patients (20-49 years old) with stage I-III colon cancers were identified from the SEER program from 1990 to 2014. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to analyze the data. Subset analyses were also done among different age and stage subgroups...
2018: Cancer Management and Research
Li-Ying Tang, Mou-Xin Zhang, Di-Han Lu, Yong-Xiong Chen, Zu-Guo Liu, San-Gang Wu
Introduction: Orbital embryonal rhabdomyosarcoma is a rare childhood malignancy with a good prognosis, but the optimal treatment remains unclear. Using a population-based cancer registry, we assessed the prognoses and survival outcomes of patients with orbital embryonal rhabdomyosarcoma according to the local treatment strategy. Patients and methods: Patients diagnosed with orbital embryonal rhabdomyosarcoma between 1988 and 2012 as part of the Surveillance Epidemiology and End Results program were included...
2018: Cancer Management and Research
Tingdong Yu, Xiangkun Wang, Guangzhi Zhu, Chuangye Han, Hao Su, Xiwen Liao, Chengkun Yang, Wei Qin, Ketuan Huang, Tao Peng
Objective: The activities of four cytochrome P3A (CYP3A) subfamily members (CYP3A4, CYP3A5, CYP3A7, and CYP3A43) are well documented in drug metabolism. However, the association between CYP3A subfamily members and hepatocellular carcinoma (HCC) remains unclear. This study investigated the prognostic value of CYP3A subfamily mRNA expression levels with HCC prognosis. Materials and methods: Data from a total of 360 HCC patients were retrieved from The Cancer Genome Atlas database, and data from 231 HCC patients were retrieved from the Gene Expression Omnibus database...
2018: Cancer Management and Research
Shuai Zhang, Liya Zhou, Xiaopeng Huang, Shaomin Lin
Introduction: The purpose of this study was to analyze the efficacy and safety of concurrent chemoradiotherapy plus S-1 adjuvant chemotherapy for N3 stage nasopharyngeal carcinoma (NPC). Methods: This study included 44 N3 stage NPC patients treated with concurrent chemoradiotherapy plus S-1 adjuvant chemotherapy. The intensity-modulated radiation therapy doses were planning target volume (PTV) 70-72 Gy for gross disease in the nasopharynx and 66-70 Gy for positive lymph nodes...
2018: Cancer Management and Research
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