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Cancer Management and Research

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https://www.readbyqxmd.com/read/28293120/glucocorticoid-receptor-expression-in-20-solid-tumor-types-using-immunohistochemistry-assay
#1
Thaddeus S Block, Tiffany I Murphy, Pamela N Munster, Dat P Nguyen, Frank J Lynch
BACKGROUND: Glucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors. A novel immunohistochemistry (IHC) based assay has been previously developed and validated in order to assess GR immunoreactivity in triple-negative breast cancer. The current study investigates the standardized use of this validated assay to assess GR expression in a broad range of solid tumor malignancies...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28280389/update-on-the-optimal-use-of-bortezomib-in-the-treatment-of-multiple-myeloma
#2
REVIEW
Meera Mohan, Aasiya Matin, Faith E Davies
The proteasome inhibitor (PI) "bortezomib" has now been in routine clinical practice for over a decade. It is now considered an important backbone therapy for all stages of the disease, and data continue to grow to support its use in newly diagnosed patients, relapsed and relapsed/refractory disease, maintenance therapy, high risk, and renal failure. Much has been learnt about the most clinically effective way of delivering therapy, with patients often benefiting more from a triplet bortezomib combination compared to a doublet combination...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28260945/differential-pharmacology-and-clinical-utility-of-rolapitant-in-chemotherapy-induced-nausea-and-vomiting
#3
REVIEW
Bernardo Leon Rapoport
Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of many cytotoxic chemotherapy regimens. CINV typically manifests during two well-defined time periods (acute and delayed phases). The acute phase is the first 24 hours after chemotherapy and is largely managed with 5-hydroxytryptamine 3 receptor antagonists. The delayed phase, a 5-day at-risk period during which patients are not often in direct contact with their health care provider, remains a significant unmet medical need. Neurokinin-1 (NK-1) receptor antagonists have demonstrated protection against acute and delayed CINV in patients treated with highly emetogenic chemotherapy and moderately emetogenic chemotherapy when used in combination with a 5-hydroxytryptamine 3 receptor antagonist and dexamethasone...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28228661/feasibility-of-an-exercise-intervention-for-fatigued-breast-cancer-patients-at-a-community-based-cardiac-rehabilitation-program
#4
Stefanie De Jesus, Lyndsay Fitzgeorge, Karen Unsworth, David Massel, Neville Suskin, Harry Prapavessis, Michael Sanatani
PURPOSE: Exercise is beneficial to quality of life after cancer treatment, yet few cancer survivors meet exercise guidelines. Our study sought to determine the feasibility of an oncology rehabilitation exercise program embedded within a cardiac rehabilitation program. METHODS: Patients who rated their fatigue >4/10 after completion of adjuvant chemotherapy for breast cancer were screened for eligibility and the outcomes were assessed (Piper Fatigue Scale, Functional Assessment of Cancer Therapy-Breast [FACT-B], Edmonton Symptom Assessment System, body composition, stress test, and physical activity measurement [accelerometer])...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28223846/prospect-of-the-use-of-checkpoint-inhibitors-in-hepatocellular-cancer-treatments
#5
REVIEW
Ali Raufi, Maria Tria Tirona
Hepatocellular cancer (HCC) is a very fatal disease due to limited therapeutic options as well as due to its association with underlying chronic liver disease in the majority of cases. The immune evasion in HCC signifies a major barrier to the delivery of effective immunotherapy. Sorafenib is the only Food and Drug Administration-approved drug available with an overall response rate of 2%-3% and overall survival of 2.8 months. Chemotherapy has not been used routinely because of the relative refractoriness of advanced HCC...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28203106/antioxidant-activity-of-ginger-extract-as-a-daily-supplement-in-cancer-patients-receiving-adjuvant-chemotherapy-a-pilot-study
#6
Kwanjit Danwilai, Jitprapa Konmun, Bung-Orn Sripanidkulchai, Suphat Subongkot
PURPOSE: The aim of this study was to examine the antioxidant activity of ginger extract oral supplement in newly diagnosed cancer patients receiving adjuvant chemotherapy compared to placebo. PATIENTS AND METHODS: Newly diagnosed cancer patients receiving moderate-to-high emetogenic potential adjuvant chemotherapy were randomized to receive either a ginger extract (standardized 6-gingerol 20 mg/day) or a placebo 3 days prior to chemotherapy, which they continued daily...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28203105/association-of-fatigue-and-depression-with-circulating-levels-of-proinflammatory-cytokines-and-epidermal-growth-factor-receptor-ligands-a-correlative-study-of-a-placebo-controlled-fatigue-trial
#7
Tyvin Rich, Fengmin Zhao, Ricardo A Cruciani, David Cella, Judith Manola, Michael J Fisch
CONTEXT: The biology of fatigue and depression in cancer patients is poorly understood. Hypotheses regarding cytokines and growth factors related to sickness behavior and disruption of circadian signaling have been proposed. OBJECTIVES: We prospectively examined proinflammatory cytokines (e.g., sickness behavior model) and epidermal growth factor receptor (EGFR) ligands (e.g., circadian disruption model) in the serum of cancer patients enrolled in a clinical trial testing levocarnitine for fatigue...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/27877066/implantation-of-permanent-pleural-catheter-for-palliation-of-malignant-pleural-effusion
#8
Michelle Meier, Marie Riis Mortensen, Lene Unmack Larsen
PURPOSE: Malignant pleural effusion (MPE) is a disabling condition caused in most instances by far-advanced cancer. The treatment is palliative and should ideally be minimally invasive. The aim of this retrospective study was to evaluate the effectiveness of implantation of a permanent PleurX catheter in the treatment of recurrent MPE in patients with terminal cancer disease. PATIENTS AND METHODS: Eighteen consecutive patients with terminal cancer and MPE, who had a permanent PleurX catheter implanted in the period from February 2014 to August 2015, were retrospectively evaluated...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27799819/treatment-challenges-for-community-oncologists-treating-postmenopausal-women-with-endocrine-resistant-hormone-receptor-positive-human-epidermal-growth-factor-receptor-2-negative-advanced-breast-cancer
#9
https://www.readbyqxmd.com/read/27695363/atypical-teratoid-rhabdoid-tumors-challenges-and-search-for-solutions
#10
REVIEW
Ahitagni Biswas, Lakhan Kashyap, Aanchal Kakkar, Chitra Sarkar, Pramod Kumar Julka
Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous system tumor commonly affecting children <3 years of age. It roughly constitutes 1%-2% of all pediatric central nervous system tumors. Recent data show that it is the most common malignant central nervous system tumor in children <6 months of age. Management of this aggressive tumor is associated with a myriad of diagnostic and therapeutic challenges. On the basis of radiology and histopathology alone, distinction of AT/RT from medulloblastoma or primitive neuroectodermal tumor is difficult, and hence this tumor has been commonly misdiagnosed as primitive neuroectodermal tumor for decades...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27578998/role-of-tolvaptan-in-the-management-of-hyponatremia-in-patients-with-lung-and-other-cancers-current-data-and-future-perspectives
#11
REVIEW
Bijin Thajudeen, Abdulla K Salahudeen
Hyponatremia is the most frequently observed electrolyte abnormality in clinical practice, and its frequency is almost double in hospitalized cancer patients. As a subset of cancer, hyponatremia is quite common in lung cancer patients, and it is often coupled with the diagnosis of syndrome of inappropriate antidiuretic hormone secretion. The presence of hyponatremia is consequential in that its presence adversely affects cancer patients' prognosis and outcomes. Limited data suggest that correcting hyponatremia in lung cancer patients can increase response to anticancer treatment, may help reduce length of hospital stay and cost, and reduce morbidity and mortality...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27574465/advanced-soft-tissue-sarcoma-and-treatment-options-critical-appraisal-of-trabectedin
#12
REVIEW
Ingrid M E Desar, Anastasia Constantinidou, Suzanne E J Kaal, Robin L Jones, Winette T A van der Graaf
Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis on trabectedin. Trabectedin is a unique type of chemotherapeutic agent with multiple potential mechanisms of action. We discuss the putative mechanisms, as well as the toxicity and administration schedules of trabectedin, followed by its efficacy in first-line systemic therapy and beyond first-line systemic therapy...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27468248/treatment-challenges-for-community-oncologists-treating-postmenopausal-women-with-endocrine-resistant-hormone-receptor-positive-human-epidermal-growth-factor-receptor-2-negative-advanced-breast-cancer
#13
REVIEW
William J Gradishar
Community-based oncologists are faced with challenges and opportunities when delivering quality patient care, including high patient volumes and diminished resources; however, there may be the potential to deliver increased patient education and subsequently improve outcomes. This review discusses the treatment of postmenopausal women with endocrine-resistant, hormone receptor-positive, human epidermal growth factor receptor 2- negative advanced breast cancer in order to illustrate considerations in the provision of pertinent quality education in the treatment of these patients and the management of therapy-related adverse events...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27390532/erratum-reappraisal-of-the-role-of-dolasetron-in-prevention-and-treatment-of-nausea-and-vomiting-associated-with-surgery-or-chemotherapy-erratum
#14
(no author information available yet)
[This corrects the article on p. 67 in vol. 4, PMID: 22427733.].
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27382332/fosaprepitant-dimeglumine-for-the-management-of-chemotherapy-induced-nausea-and-vomiting-patient-selection-and-perspectives
#15
REVIEW
Nellowe Candelario, Marvin Louis Roy Lu
Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of antineoplastic agents. Several treatment regimens are used to address this problem. Fosaprepitant is a neurokinin-1 receptor blocker used in the prevention and treatment of CINV, especially for moderately and severely emetogenic chemotherapy. It is highly effective in the treatment of delayed CINV. Data from previous studies show that fosaprepitant is noninferior to aprepitant in the management of CINV. Fosaprepitant is given as a single-dose intravenous infusion, thus offering better patient compliance...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27313476/treatment-patterns-health-state-and-health-care-resource-utilization-of-patients-with-radioactive-iodine-refractory-differentiated-thyroid-cancer
#16
Andrew G Gianoukakis, Natalia M Flores, Corey L Pelletier, Anna Forsythe, Gregory R Wolfe, Matthew H Taylor
BACKGROUND: Patients with differentiated thyroid cancer (DTC) often respond well to treatment but some become refractory to radioactive iodine (RAI) treatment, and treatment options are limited. Despite the humanistic and economic burden RAI refractory disease imposes on patients, published research concerning treatment patterns and health care resource utilization is sparse. METHODS: Data were collected from an online retrospective chart review study in the US and five European Union (EU) countries (France, Germany, Italy, Spain, and UK) with physicians recruited from an online panel...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27274311/novel-approaches-to-target-her2-positive-breast-cancer-trastuzumab-emtansine
#17
REVIEW
Gonzalo Recondo, Maximo de la Vega, Fernando Galanternik, Enrique Díaz-Cantón, Bernardo Amadeo Leone, José Pablo Leone
The human epidermal growth factor receptor 2 (HER2) is overexpressed in 20% of breast carcinomas. Prior to the development of targeted therapies, HER2-positive breast cancer was associated with more aggressive disease and poor prognosis. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that results from the combination of trastuzumab and DM1, a derivative of the antimicrotubule agent maytansine. This molecule has the ability to enhance cytotoxic drug delivery to specifically targeted cells that overexpress HER2, therefore, maximizing efficacy while sparing toxicity...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27274310/dronabinol-for-chemotherapy-induced-nausea-and-vomiting-unresponsive-to-antiemetics
#18
REVIEW
Megan Brafford May, Ashley E Glode
Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appropriate medications. Several antiemetic options exist to manage CINV. Corticosteroids, serotonin receptor antagonists, and neurokinin receptor antagonists are the classes most commonly used in the prevention of CINV. There are many alternative drug classes utilized for the prevention and management of CINV such as antihistamines, benzodiazepines, anticonvulsants, cannabinoids, and dopamine receptor antagonists...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27274309/discoveries-and-application-of-prostate-specific-antigen-and-some-proposals-to-optimize-prostate-cancer-screening
#19
Shinkan Tokudome, Ryosuke Ando, Yoshiro Koda
The discoveries and application of prostate-specific antigen (PSA) have been much appreciated because PSA-based screening has saved millions of lives of prostate cancer (PCa) patients. Historically speaking, Flocks et al first identified antigenic properties in prostate tissue in 1960. Then, Barnes et al detected immunologic characteristics in prostatic fluid in 1963. Hara et al characterized γ-semino-protein in semen in 1966, and it has been proven to be identical to PSA. Subsequently, Ablin et al independently reported the presence of precipitation antigens in the prostate in 1970...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27217796/multidisciplinary-management-for-esophageal-and-gastric-cancer
#20
REVIEW
Megan M Boniface, Sachin B Wani, Tracey E Schefter, Phillip J Koo, Cheryl Meguid, Stephen Leong, Jeffrey B Kaplan, Lisa J Wingrove, Martin D McCarter
The management of esophageal and gastric cancer is complex and involves multiple specialists in an effort to optimize patient outcomes. Utilizing a multidisciplinary team approach starting from the initial staging evaluation ensures that all members are in agreement with the plan of care. Treatment selection for esophageal and gastric cancer often involves a combination of chemotherapy, radiation, surgery, and palliative interventions (endoscopic and surgical), and direct communication between specialists in these fields is needed to ensure appropriate clinical decision making...
2016: Cancer Management and Research
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