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Journal of Inflammation Research

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https://www.readbyqxmd.com/read/30319283/regulatory-t-cells-antagonize-proinflammatory-response-of-il-17-during-cutaneous-tuberculosis
#1
Chaman Saini, Praveen Kumar, Mohd Tarique, Alpana Sharma, Venkatesh Ramesh
Background: The clinical forms of cutaneous tuberculosis (CTB) consist of a spectrum that reflects the host's immune response to Mycobacterium tuberculosis ; it provides an ideal model to study the immunological dysregulation in humans. IL-17 plays an important role in initial immune response and is involved in both immune-mediated protection and pathology during M. tuberculosis infection. TGF-β producing regulatory T-cells (Tregs) are high in leprosy patients and responsible for immune suppression...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30319282/erratum-chronic-tonsillitis-and-biofilms-a-brief-overview-of-treatment-modalities-corrigendum
#2
(no author information available yet)
[This corrects the article on p. 329 in vol. 11, PMID: 30233227.].
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30288079/spotlight-on-the-nlrp3-inflammasome-pathway
#3
REVIEW
Marine Groslambert, Bénédicte F Py
Inflammation is triggered by a repertoire of receptors detecting infections and damages. Some of these receptors directly bind microbial ligands, while others recognize endogenous molecules exposed under stress conditions, including infections. Most of these receptors can be engaged by a relatively limited number of stimuli. Differently, NLRP3 acts as a broad sensor of cell homeostasis rupture and can be activated downstream of a plethora of stimuli. NLRP3 then assembles a multiprotein platform resulting in caspase-1 activation, which controls, by direct cleavage, the maturation of cytosolic pro-cytokines including pro-interleukin-1β...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30288078/inflammatory-gene-mrna-expression-in-human-peripheral-blood-and-its-association-with-colorectal-cancer
#4
Reem Abdullah Alamro, Mohammad Mustafa, Abdulrahman K Al-Asmari
Objective: The present study planned to investigate the changes in the mRNA expression of inflammatory genes and their association with colorectal cancer (CRC). Our findings could be useful for noninvasive early screening of CRC patients. Patients and methods: Venous blood of 20 CRC cases and 15 healthy controls was collected. The mRNA expression of COX-2, TNF-α, NF-κB and IL-6 genes was carried out by using real-time polymerase chain reaction. Relative quantification was done to find out the fold change of these genes...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30288077/the-role-of-inflammation-in-irritable-bowel-syndrome-ibs
#5
REVIEW
Qin Xiang Ng, Alex Yu Sen Soh, Wayren Loke, Donovan Yutong Lim, Wee-Song Yeo
Irritable bowel syndrome (IBS) is a complex, functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort and altered bowel habits. Despite the global prevalence and disease burden of IBS, its underlying pathophysiology remains unclear. Inflammation may play a pathogenic role in IBS. Studies have highlighted the persistence of mucosal inflammation at the microscopic and molecular level in IBS, with increased recruitment of enteroendocrine cells. Substantial overlaps between IBS and inflammatory bowel disease have also been reported...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30237730/sacroiliitis-early-diagnosis-is-key
#6
REVIEW
Gleb Slobodin, Haya Hussein, Itzhak Rosner, Iris Eshed
Sacroiliitis, inflammation of the sacroiliac joint (SIJ), may be associated with many rheumatic and nonrheumatic disorders. The diagnosis of sacroiliitis may be difficult in many patients, and awareness of its typical manifestations along with recognition of its diverse presentations and cognizance of the limitations of today's imaging modalities are critical to good clinical practice. This review presents the didactic approach to the early diagnosis of sacroiliitis in patients with suspected axial spondyloarthritis and other nosologic entities, discussing also differential interpretation of information acquired from patients' histories, physical examination, and imaging...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30233227/chronic-tonsillitis-and-biofilms-a-brief-overview-of-treatment-modalities
#7
REVIEW
Muhamad Abu Bakar, Judy McKimm, Seraj Zohurul Haque, Md Anwarul Azim Majumder, Mainul Haque
Recurrent tonsillitis is described as when an individual suffers from several attacks of tonsillitis per year. Chronic and recurrent tonsillitis both cause repeated occurrences of inflamed tonsils which have a significant impact on a patient's quality of life. Numerous children suffer from recurrent tonsillitis and sore throats, and these illnesses become part of their life. Antimicrobials can provide temporary relief, but in many cases, tonsillitis recurs. The cause of such recurrent infections have been identified as microorganisms which often create biofilms and a repository of infection in the wet and warm folds of the tonsils...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30214266/fecal-microbiota-transplant-a-new-frontier-in-inflammatory-bowel-disease
#8
REVIEW
Tagore Sunkara, Prashanth Rawla, Andrew Ofosu, Vinaya Gaduputi
Inflammatory bowel disease (IBD) is a chronic multifactorial disease that affects the gastrointestinal tract and results from an aberrant immune response toward luminal antigens in genetically susceptible people. Most of the current therapies for IBD focus on the management of the inflammation by using corticosteroids, immune modulators, and more recently, monoclonal antibodies (biological therapy). Although these therapies provide benefit in most cases, there are still a significant number of patients who do not respond or become refractory over time, suggesting the need for alternative therapeutic options...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30154671/current-treatment-of-acute-perforated-diverticulitis-the-role-of-damage-control-surgery
#9
COMMENT
Maurizio Zizzo, Antonio Manenti, Lara Ugoletti
No abstract text is available yet for this article.
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30122972/medicinal-plants-with-anti-inflammatory-activities-from-selected-countries-and-regions-of-africa
#10
REVIEW
Oluwafemi O Oguntibeju
Various nonsteroidal anti-inflammatory drugs have been shown to reduce pain and inflammation by blocking the metabolism of arachidonic acid by isoform of cyclooxygenase enzyme, thereby reducing the production of prostaglandin. Sadly, there are many side effects associated with the administration of nonsteroidal anti-inflammatory drugs. However, there are medicinal plants with anti-inflammatory therapeutic effects with low or no side effects. The Afri-can continent is richly endowed with diverse medicinal plants with anti-inflammatory activities that have been shown to be effective in the treatment of inflammatory conditions in traditional medicine...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30100749/cell-adhesion-molecules-and-exercise
#11
REVIEW
Yunsuk Koh, Jinkyung Park
Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis. Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. resistance) of exercise on intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectins...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/30022847/il-1%C3%AE-correlates-with-severity-of-hepatitis-c-virus-related-liver-diseases
#12
Ahmed Khaled Tawfik, Ahmed Mustafa Amin, Mohamed Yousef, Noha Mohamed El-Sayd, Heba Elashry, Mahmoud Elkadeem, Sherief Abd-Elsalam
Background and aims: Immunoregulatory cytokines influence the persistence of hepatitis C virus (HCV) chronic infection and the extent of liver damage. Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1α production was impaired in patients with chronic infections of HCV, implying that IL-1α may play a role in viral clearance. The aim of this study was to evaluate the serum level of proinflammatory cytokine IL-1α in patients with chronic hepatitis C (CHC)...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29950881/the-two-faces-of-pannexins-new-roles-in-inflammation-and-repair
#13
REVIEW
Helen P Makarenkova, Sameer B Shah, Valery I Shestopalov
Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An increasing body of literature on pannexins suggests that these channels play dual and sometimes contradictory roles, contributing to normal cell function, as well as to the pathological progression of disease. In this review, we summarize our understanding of pannexin "protective" and "harmful" functions in inflammation, regeneration and mechanical signaling. We also suggest a possible basis for pannexin's dual roles, related to extracellular ATP and K+ levels and the activation of various types of P2 receptors that are associated with pannexin...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29950880/the-effect-of-hydroalcoholic-extract-of-teucrium-polium-l-on-the-inflammatory-markers-and-lipid-profile-in-hypercholesterolemic-rats
#14
Mansour Amraei, Ayub Ghorbani, Yaser Seifinejad, Seyedeh Fatemeh Mousavi, Mahmoud Mohamadpour, Ehsan Shirzadpour
Background: Cardiovascular diseases are among the most common causes of mortality worldwide. Therefore, it is necessary to control the risk factors of these patients. Since the level of inflammatory markers and lipid profiles has increased in cardiovascular diseases and due to the increasing role of plants in the treatment of diseases, the current study aimed to investigate the effect of hydroalcoholic extract of Teucrium polium on inflammatory markers and lipid profile in hypercholesterolemic rats...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29922081/is-there-a-link-between-inflammation-and-fatigue-in-multiple-sclerosis
#15
REVIEW
Moussa A Chalah, Samar S Ayache
Purpose: Among autoimmune diseases of the central nervous system stands multiple sclerosis (MS), which is characterized by demyelination, synaptopathy, and neurodegeneration. MS fatigue can affect up to 90% of patients and be very disabling, with a drastic impact on their quality of life. To date, the evaluation of MS fatigue has relied mainly on subjective scales, and actual therapeutic interventions are challenged by modest efficacy and numerous undesirable effects. Therefore, finding biomarkers of MS fatigue might help in optimizing evaluation and treatment strategies...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29922080/factors-correlated-with-the-improvement-of-endothelial-dysfunction-during-abatacept-therapy-in-patients-with-rheumatoid-arthritis
#16
Maurizio Benucci, Francesca Bandinelli, Arianna Damiani, Francesca Li Gobbi, Maria Infantino, Valentina Grossi, Mariangela Manfredi
Background: Rheumatoid arthritis patients are exposed to a high risk of cardiovascular morbidity and mortality even in the early phases of the disease. Methods: We evaluated carotid common carotid intimal media thickness (ccIMT) intimal thickness and brachial flow-mediated dilation (FMD) of 45 rheumatoid arthritis patients without known cardiovascular risk factors or heart disease on a stable dose of prednisone 5.2±1.2 mg/day and Methotrexate 11.5±2.1 mg at baseline (T0) and after 12 months (T1) of treatment with Abatacept 125 mg/week...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29881303/inflammation-management-in-acute-diverticulitis-current-perspectives
#17
REVIEW
Marco Ceresoli, Giulia Lo Bianco, Luca Gianotti, Luca Nespoli
The pathogenesis of diverticular disease and acute diverticulitis is still unclear and many different hypotheses have been formulated. Seemingly, there are several related factors such as chronic inflammation, gut microbiome, obesity and the immunogenic properties of fat tissue and diet. Inflammation plays a pivotal role in diverticular disease and acute diverticulitis. The aim of the present review is to investigate the role of inflammation in diverticular disease as well as in mild and complicated acute diverticulitis with a focus on current research and treatment perspectives...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29844696/electroacupuncture-therapy-in-inflammation-regulation-current-perspectives
#18
REVIEW
Ji-Yeun Park, Uk Namgung
Although acupuncture therapy is increasingly used to treat diverse symptoms and disorders in humans, its underlying mechanism is not known well. Only recently have experimental studies begun to provide insights into how acupuncture stimulation generates and relates to pathophysiological responsiveness. Acupuncture intervention is frequently used to control pathologic symptoms in several visceral organs, and a growing number of studies using experimental animal models suggest that acupuncture stimulation may be involved in inducing anti-inflammatory responses...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29844695/role-of-biologics-and-biosimilars-in-inflammatory-bowel-disease-current-trends-and-future-perspectives
#19
REVIEW
Prashanth Rawla, Tagore Sunkara, Jeffrey Pradeep Raj
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of the gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative colitis and Crohn's disease. The incidence of IBD has been increasing steadily since 1990, and so the number of agents used in their treatment. Biologics that are derived partly or completely from living biological sources such as animals and humans have become widely available, which provide therapeutic benefits to the IBD patients. Currently, monoclonal antibodies against tumor necrosis factor-alpha (infliximab, adalimumab, certolizumab, and golimumab), integrins (vedolizumab and natalizumab), and interleukin (IL)-12 and IL-23 antagonists (ustekinumab) are approved for use in IBD...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29844694/a-review-of-vagus-nerve-stimulation-as-a-therapeutic-intervention
#20
REVIEW
Rhaya L Johnson, Christopher G Wilson
In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders...
2018: Journal of Inflammation Research
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