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Journal of Inflammation Research

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https://www.readbyqxmd.com/read/27920568/reduced-butyrylcholinesterase-activity-is-an-early-indicator-of-trauma-induced-acute-systemic-inflammatory-response
#1
Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer, Karsten Schmidt
PURPOSE: Early diagnosis of systemic inflammatory response syndrome is fundamentally important for an effective and a goal-directed therapy. Various inflammation biomarkers have been used in clinical and experimental practice. However, a definitive diagnostic tool for an early detection of systemic inflammation remains to be identified. Acetylcholine (Ach) has been shown to play an important role in the inflammatory response. Serum cholinesterase (butyrylcholinesterase [BChE]) is the major Ach hydrolyzing enzyme in blood...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27920567/evaluation-of-bode-index-and-its-relationship-with-systemic-inflammation-mediated-by-proinflammatory-biomarkers-in-patients-with-copd
#2
Naushad Ahmad Khan, Mradul Kumar Daga, Istaq Ahmad, Govind Mawari, Suman Kumar, Naresh Kumar, Syed Akhter Husain
INTRODUCTION: BODE index, a multidimensional grading system which is based on Body mass index, airway Obstruction, Dyspnea scale, and Exercise capacity, has been increasingly used for the evaluation of chronic obstructive pulmonary disease (COPD). Many of the systemic manifestations of COPD are shown to be mediated by elevated levels of proinflammatory biomarkers. OBJECTIVE: We aimed to investigate the relationship between the BODE index, its components, disease severity, and proinflammatory biomarkers like C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27895507/fc-gamma-receptors-glycobiology-and-therapeutic-prospects
#3
REVIEW
Jerrard M Hayes, Mark R Wormald, Pauline M Rudd, Gavin P Davey
Therapeutic antibodies hold great promise for the treatment of cancer and autoimmune diseases, and developments in antibody-drug conjugates and bispecific antibodies continue to enhance treatment options for patients. Immunoglobulin (Ig) G antibodies are proteins with complex modifications, which have a significant impact on their function. The most important of these modifications is glycosylation, the addition of conserved glycans to the antibody Fc region, which is critical for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, complement activation and phagocytosis...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27843334/targeting-neuroinflammation-in-alzheimer-s-disease
#4
REVIEW
Maria Rosanna Bronzuoli, Aniello Iacomino, Luca Steardo, Caterina Scuderi
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer's disease (AD) accounts for approximately 60%-80% of all dementia cases. Given this evidence, it is clear dementia represents one of the greatest global public health challenges. Currently used drugs alleviate the symptoms of AD but do not treat the underlying causes of dementia. Hence, a worldwide quest is under way to find new treatments to stop, slow, or even prevent AD. Besides the classic targets of the oldest therapies, represented by cholinergic and glutamatergic systems, β-amyloid (Aβ) plaques, and tau tangles, new therapeutic approaches have other targets...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27799809/insights-into-the-molecular-etiology-of-exercise-induced-inflammation-opportunities-for-optimizing-performance
#5
REVIEW
Ioannis G Fatouros, Athanasios Z Jamurtas
The study of exercise-induced muscle damage (EIMD) is of paramount importance not only because it affects athletic performance but also because it is an excellent model to study the mechanisms governing muscle cachexia under various clinical conditions. Although, a large number of studies have investigated EIMD and its associated inflammatory response, several aspects of skeletal muscles responses remain unclear. In the first section of this article, the mechanisms of EIMD are reviewed in an attempt to follow the events that result in functional and structural alterations of skeletal muscle...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27785087/adiponectin-treatment-attenuates-inflammatory-response-during-early-sepsis-in-obese-mice
#6
XianFeng Wang, Nancy L Buechler, Barbara K Yoza, Charles E McCall, Vidula Vachharajani
BACKGROUND: Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in obese patients. We have shown that adiponectin deficiency increases microvascular dysfunction in early sepsis...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27703392/the-treatment-of-nonunions-with-application-of-bmp-7-increases-the-expression-pattern-for-angiogenic-and-inflammable-cytokines-a-matched-pair-analysis
#7
Patrick Haubruck, Andreas Kammerer, Sebastian Korff, Philipp Apitz, Kai Xiao, Axel Büchler, Bahram Biglari, Gerald Zimmermann, Volker Daniel, Gerhard Schmidmaier, Arash Moghaddam
The local application of bone morphogenetic protein-7 (BMP-7) in combination with the transplantation of autologous bone graft improves the outcome in nonunion treatment; however, the specific reasons remain unclear. In this study, we sought to determine if the local application of BMP-7 contributes to improved bone regeneration in nonunion therapy by modulation of the angiogenic and inflammable cytokine expression patterns of the early inflammation response. Therefore, we utilized the analysis of serological cytokine expression patterns...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27621662/curcumin-prevents-muscle-damage-by-regulating-nf-%C3%AE%C2%BAb-and-nrf2-pathways-and-improves-performance-an-in-vivo-model
#8
Kazim Sahin, Ragip Pala, Mehmet Tuzcu, Oguzhan Ozdemir, Cemal Orhan, Nurhan Sahin, Vijaya Juturu
PURPOSE: Exercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex. MATERIALS AND METHODS: Twenty-eight (28) male Wistar rats (age: 8 weeks and body weight: 180±20 g) were divided into four treatment groups: 1) control (C; no Ex), 2) C + CW (no Ex + CW), 3) C + Ex, and 4) C + Ex + CW (Ex + CW)...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27468246/significance-of-mast-cell-distribution-in-placental-tissue-and-membranes-in-spontaneous-preterm-birth
#9
Kate Needham, Mitali Fadia, Jane E Dahlstrom, Kirsti Harrington, Bruce Shadbolt, Stephen J Robson
BACKGROUND: Preterm birth is a common cause of adverse neonatal and childhood outcomes, in both the short and long term. Preterm labor is commonly associated with inflammation at the maternal-fetal interface. There is some indirect evidence that mast cells (MCs) might represent a link between hormonal influences and local reactions leading to the onset of labor. PATIENTS AND METHODS: The placentas and membranes of 51 uncomplicated spontaneous term births were compared to those from 50 spontaneous preterm births...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27382325/association-of-tumor-necrosis-factor-%C3%AE-and-%C3%AE-gene-polymorphisms-in-inflammatory-bowel-disease
#10
Ebtissam Saleh Al-Meghaiseeb, Abdulrahman A Al-Robayan, Mulfi Mubarak Al-Otaibi, Misbahul Arfin, Abdulrahman K Al-Asmari
Inflammatory bowel disease (IBD) is a complex, multifactorial, chronic inflammatory disorder of the gastrointestinal tract in which immune dysregulation caused by genetic and/or environmental factors plays an important role. The aim of this case-control study was to evaluate the association of tumor necrosis factor-alpha (TNF-α) (308) and -β (+252) polymorphisms with susceptibility of IBD. A total of 379 Saudi subjects including 179 IBD patients (ulcerative colitis (UC) =84 and Crohn's disease (CD) =95) and 200 age- and sex-matched healthy controls were recruited...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27366101/vitamin-d-and-the-immunomodulation-of-rotator-cuff-injury
#11
REVIEW
Kaitlin A Dougherty, Matthew F Dilisio, Devendra K Agrawal
Tendon-to-bone healing after rotator cuff repair surgery has a failure rate of 20%-94%. There has been a recent interest to determine the factors that act as determinants between successful and unsuccessful rotator cuff repair. Vitamin D level in patients is one of the factors that have been linked to bone and muscle proliferation and healing, and it may have an effect on tendon-to-bone healing. The purpose of this article is to critically review relevant published research that relates to the effect of vitamin D on rotator cuff tears and subsequent healing...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27366100/tnf-related-apoptosis-inducing-ligand-deficiency-enhances-survival-in-murine-colon-ascendens-stent-peritonitis
#12
Katharina Beyer, Laura Stollhof, Christian Poetschke, Wolfram von Bernstorff, Lars Ivo Partecke, Stephan Diedrich, Stefan Maier, Barbara M Bröker, Claus-Dieter Heidecke
BACKGROUND: Apart from inducing apoptosis in tumor cells, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) influences inflammatory reactions. Murine colon ascendens stent peritonitis (CASP) represents a model of diffuse peritonitis. Recently, it has been demonstrated that administration of exogenous TRAIL not only induces apoptosis in neutrophils but also enhances survival in this model. The aim of this study was to examine the impact of genetic TRAIL deficiency on the course of CASP...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27358572/caf1-knockout-mice-are-more-susceptive-to-lipopolysaccharide-induced-acute-lung-injury
#13
Jia-Xin Shi, Jia-Shu Li, Rong Hu, Xiao-Min Li, Hong Wang
The carbon catabolite repressor protein 4 (CCR4)-negative on TATA (NOT) complex includes multiple subunits and is conserved in the eukaryotic cells. The CCR4-NOT complex can regulate gene expression at different levels. Two subunits of the CCR4-NOT complex, CCR4 and CCR4-associated factor 1 (CAF1), possess deadenylase activity. In yeast, the deadenylase activity is mainly provided by the CCR4 subunit; however, the deadenylase activity is provided by both CCR4 and CAF1 in other eukaryotes. A previous study reported that CAF1 but not CCR4 is required for the decay of a reporter mRNA with AU-rich elements...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27330321/toll-like-receptor-cascade-and-gene-polymorphism-in-host-pathogen-interaction-in-lyme-disease
#14
REVIEW
Shusmita Rahman, Maria Shering, Nicholas H Ogden, Robbin Lindsay, Alaa Badawi
Lyme disease (LD) risk occurs in North America and Europe where the tick vectors of the causal agent Borrelia burgdorferi sensu lato are found. It is associated with local and systemic manifestations, and has persistent posttreatment health complications in some individuals. The innate immune system likely plays a critical role in both host defense against B. burgdorferi and disease severity. Recognition of B. burgdorferi, activation of the innate immune system, production of proinflammatory cytokines, and modulation of the host adaptive responses are all initiated by Toll-like receptors (TLRs)...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27274303/protective-effect-of-soybean-oil-or-fish-oil-rich-diets-on-allergic-airway-inflammation
#15
Roberta Araujo Navarro-Xavier, Karina Vieira de Barros, Iracema Senna de Andrade, Zaira Palomino, Dulce Elena Casarini, Vera Lucia Flor Silveira
BACKGROUND: The increased prevalence of asthma and allergic diseases in westernized societies has been associated with increased intake of diets rich in n-6 fatty acids (FAs) and poor in n-3 FAs. This study aimed to analyze the prophylactic effects of treatment with a soybean oil-rich diet (rich in n-6) or fish oil (rich in n-3) in an allergic airway inflammation model on lung inflammation score, leukocyte migration, T-helper cell (Th)-2 (interleukin [IL]-4, IL-5) and Th1 (interferon [IFN]-γ, tumor necrosis factor-α) cytokines, lipoxin A4, nitric oxide, bradykinin, and corticosterone levels in bronchoalveolar lavage (BAL) or lungs...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27274302/impaired-bone-healing-in-multitrauma-patients-is-associated-with-altered-leukocyte-kinetics-after-major-trauma
#16
Okan W Bastian, Anne Kuijer, Leo Koenderman, Rebecca K Stellato, Wouter W van Solinge, Luke Ph Leenen, Taco J Blokhuis
Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27217792/the-association-between-pro-and-anti-inflammatory-cytokine-polymorphisms-and-periventricular-leukomalacia-in-newborns-with-hypoxic-ischemic-encephalopathy
#17
Marta Lúcia Gabriel, Fernanda Braojos Braga, Mariana Rodero Cardoso, Ana Cláudia Lopes, Vânia Belintani Piatto, Antônio Soares Souza
BACKGROUND: Periventricular leukomalacia (PVL) is a frequent consequence of hypoxic-ischemic injury. Functional cytokine gene variants that result in altered production of inflammatory (tumor necrosis factor-alpha [TNF-α] and interleukin-1beta [IL-1β]) or anti-inflammatory (interleukin-10 [IL-10]) cytokines may modify disease processes, including PVL. OBJECTIVE: The aim of this study was to evaluate if there is a relationship between the two proinflammatory polymorphisms (TNF-α-1031T/C and IL-1β-511C/T) and the anti-inflammatory polymorphism IL-10-1082G/A and PVL risk in Brazilian newborns with and without this injury...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27175089/association-between-levels-of-vitamin-d-and-inflammatory-markers-in-healthy-women
#18
Fawaz Azizieh, Khulood O Alyahya, Raj Raghupathy
BACKGROUND: No one can deny that the biological importance of vitamin D is much beyond its classical role in bone metabolism. Several recent publications have highlighted its potential role in the functioning of the immune system. The overall objective of this study was to look into possible correlations between levels of vitamin D and inflammatory markers in sera of healthy adult women. These markers included proinflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, IL-17, interferon [IFN]-γ, and tumor necrosis factor [TNF]-α), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), as well as C-reactive protein (CRP) as a general indicator of inflammation...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27143947/generation-and-characterization-of-ixekizumab-a-humanized-monoclonal-antibody-that-neutralizes-interleukin-17a
#19
Ling Liu, Jirong Lu, Barrett W Allan, Ying Tang, Jonathan Tetreault, Chi-Kin Chow, Barbra Barmettler, James Nelson, Holly Bina, Lihua Huang, Victor J Wroblewski, Kristine Kikly
Interleukin (IL)-17A exists as a homodimer (A/A) or as a heterodimer (A/F) with IL-17F. IL-17A is expressed by a subset of T-cells, called Th17 cells, at inflammatory sites. Most cell types can respond to the local production of IL-17A because of the near ubiquitous expression of IL-17A receptors, IL-17RA and IL-17RC. IL-17A stimulates the release of cytokines and chemokines designed to recruit and activate both neutrophils and memory T-cells to the site of injury or inflammation and maintain a proinflammatory state...
2016: Journal of Inflammation Research
https://www.readbyqxmd.com/read/27114714/hypoglycemic-agents-and-potential-anti-inflammatory-activity
#20
REVIEW
Vishal Kothari, John A Galdo, Suresh T Mathews
Current literature shows an association of diabetes and secondary complications with chronic inflammation. Evidence of these immunological changes include altered levels of cytokines and chemokines, changes in the numbers and activation states of various leukocyte populations, apoptosis, and fibrosis during diabetes. Therefore, treatment of diabetes and its complications may include pharmacological strategies to reduce inflammation. Apart from anti-inflammatory drugs, various hypoglycemic agents have also been found to reduce inflammation that could contribute to improved outcomes...
2016: Journal of Inflammation Research
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