journal
MENU ▼
Read by QxMD icon Read
search

Bioanalysis

journal
https://www.readbyqxmd.com/read/28816067/post-acquisition-data-mining-techniques-for-lc-ms-ms-acquired-data-in-drug-metabolite-identification
#1
Pooja Sukhdev Dhurjad, Vamsi Krishna Marothu, Rajeshwari Rathod
Metabolite identification is a crucial part of the drug discovery process. LC-MS/MS-based metabolite identification has gained widespread use, but the data acquired by the LC-MS/MS instrument is complex, and thus the interpretation of data becomes troublesome. Fortunately, advancements in data mining techniques have simplified the process of data interpretation with improved mass accuracy and provide a potentially selective, sensitive, accurate and comprehensive way for metabolite identification. In this review, we have discussed the targeted (extracted ion chromatogram, mass defect filter, product ion filter, neutral loss filter and isotope pattern filter) and untargeted (control sample comparison, background subtraction and metabolomic approaches) post-acquisition data mining techniques, which facilitate the drug metabolite identification...
August 17, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28795582/current-status-of-bioanalytical-outsourcing-a-pharma-perspective
#2
(no author information available yet)
Eric Woolf, Ajai Chaudhary and Sheila Breidinger from Merck, spoke to Sankeetha Nadarajah (Commissioning Editor, Bioanalysis) about outsourcing strategy implementation.
August 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28795581/the-evolution-of-the-pharma-cro-working-relationship-astrazeneca-and-covance
#3
(no author information available yet)
Christopher Bailey (AstraZeneca) and Lee Goodwin (Covance) speak to Sankeetha Nadarajah (Managing Commissioning Editor, Bioanalysis) about the evolution of the Pharma-CRO working relationship between AstraZeneca and Covance.
August 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766383/are-we-ready-for-the-evolution-of-electronic-laboratory-notebooks-in-regulated-bioanalysis
#4
Jens Sydor, Grace Kim
No abstract text is available yet for this article.
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766381/development-and-validation-of-an-enzyme-linked-immunosorbent-assay-to-measure-free-eculizumab-concentration-in-serum
#5
Christophe Passot, CĂ©line Desvignes, David Ternant, Theodora Bejan-Angoulvant, Anne-Claire Duveau, Philippe Gatault, Gilles Paintaud
AIM: Eculizumab is a monoclonal antibody toward C5 fraction of the complement system. It is approved to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. To perform pharmacokinetic studies and therapeutic drug monitoring, a validated assay is required. MATERIALS & METHODS: An indirect ELISA with recombinant human C5 sensitized microtiter plates were developed. RESULTS: The assay allows the measurement of free eculizumab concentration in human serum...
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766364/overcoming-disease-specific-matrix-effect-in-a-clinical-pharmacokinetic-assay-using-a-microfluidic-immunoassay-technology
#6
Kathi Williams, Rich Erickson, Saloumeh Kadkhodayan Fischer
AIM: Etrolizumab, a humanized monoclonal antibody, has demonstrated clinical remission in a Phase II study of ulcerative colitis patients. In the Phase III program, a second indication, Crohn's disease was added. The pharmacokinetic ELISA used in the Phase I/II studies in normal human and ulcerative colitis sera exhibited matrix interference in the Crohn's disease population, necessitating implementation of a new technology. Methodology & results: Optimization of the original ELISA and assay redevelopment using different antibody pairs did not result in substantive improvements, necessitating implementation of an alternative technology for assay development...
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766363/future-trends-in-outsourcing-a-summary-of-the-bioanalysis-zone-survey
#7
Amy Craddock, Sankeetha Nadarajah
No abstract text is available yet for this article.
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766362/a-comparison-study-of-bioanalytical-methods-for-characterization-of-anti-idursulfase-antibodies
#8
Luying Pan, Kelly Hilton, Marie Nadeau, Thomas McCauley, Yongchang Qiu
AIM: Legacy methods with complex testing scheme for characterization of anti-idursulfase antibodies (ADA) were simplified and optimized in order to meet current regulatory guidance and provide more timely and cost-effective support for routine patient care. RESULTS: To compare the performance of the original and updated methods, patient samples receiving commercially prescribed Elaprase treatment were analyzed by both test methods. The ADA and neutralizing antibody results obtained by both methods were highly correlated and the updated method had an overall higher ADA and neutralizing antibody positive rates and higher ADA titers...
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28766359/best-practices-in-performing-flow-cytometry-in-a-regulated-environment-feedback-from-experience-within-the-european-bioanalysis-forum
#9
Barry van der Strate, Robin Longdin, Marie Geerlings, Nora Bachmayer, Maria Cavallin, Virginia Litwin, Minesh Patel, Wilfried Passe-Coutrin, Corinna Schoelch, Arjen Companjen, Marianne Scheel Fjording
Flow cytometry is a powerful tool that can be used for the support of (pre)clinical studies. Although various white papers are available that describe the set-up and validation of the instrumentation (the flow cytometer) and validation of flow cytometry methods, to date no guidelines exist that address the requirements for performing flow cytometry in a regulated environment. In this manuscript, the European Bioanalysis Forum presents additional practice guidance on the use of flow cytometry in the support of drug development programs and addresses areas that are not covered in the previous publications...
August 2, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763257/bioanalytical-outsourcing-transitioning-from-pharma-to-cro
#10
Roger Hayes
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763250/bioanalytical-outsourcing-models-in-pharmaceutical-companies
#11
Dieter Zimmer
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763249/interactions-between-clients-and-outsourced-cros-mind-the-gap
#12
Richard Hucker, Ian James, Scott Vincent, Carl Watson
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763245/bioanalytical-outsourcing-strategy-in-china
#13
Kelly Dong, Daniel Tang
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763241/the-changing-world-of-bioanalysis-summary-of-panel-discussions
#14
Neil Spooner, Melanie Anderson, Lieve Dillen, Luca Ferrari, Martijn Hilhorst, Zamas Lam, Marco Michi, James Munday, John Smeraglia, Scott Summerfield, Dieter Zimmer
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763238/method-transfer-a-cro-perspective
#15
Martijn J Hilhorst, Barry Wa van der Strate, Chad J Briscoe, Nico C van de Merbel
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28763237/changing-shape-evolving-an-outsourced-bioanalytical-strategy-to-support-the-changing-needs-of-drug-development
#16
Craig Stovold, Fiona Milligan, Glen Hawthorne, Colin Pattison, Amanda Wilson
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28762760/outsourcing-of-bioanalysis-at-gsk-a-hybrid-approach-with-a-robust-support-model
#17
Lee Abberley
No abstract text is available yet for this article.
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28762758/outsourcing-bioanalytical-services-at-janssen-research-and-development-the-sequel-anno-2017
#18
Lieve Dillen, Tom Verhaeghe
The strategy of outsourcing bioanalytical services at Janssen has been evolving over the last years and an update will be given on the recent changes in our processes. In 2016, all internal GLP-related activities were phased out and this decision lead to the re-orientation of the in-house bioanalytical activities. As a consequence, in-depth experience with the validated bioanalytical assays for new drug candidates is currently gained together with the external partner, since development and validation of the assay and execution of GLP preclinical studies are now transferred to the CRO...
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28762755/astrazeneca-and-covance-laboratories-clinical-bioanalysis-alliance-an-evolutionary-outsourcing-model
#19
Cecilia Arfvidsson, Paul Severin, Victoria Holmes, Richard Mitchell, Christopher Bailey, Stephanie Cape, Yan Li, Tammy Harter
The AstraZeneca and Covance Laboratories Clinical Bioanalysis Alliance (CBioA) was launched in 2011 after a period of global economic recession. In this challenging environment, AstraZeneca elected to move to a full and centralized outsourcing model that could optimize the number of people supporting bioanalytical work and reduce the analytical cost. This paper describes the key aspects of CBioA, the innovative operational model implemented, and our ways of ensuring this was much more than simply a cost reduction exercise...
August 1, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28737445/preclinical-pharmacokinetics-and-biodistribution-studies-of-asenapine-maleate-using-novel-and-sensitive-rp-hplc-method
#20
Renuka S Managuli, Karthik Gourishetti, Rekha R Shenoy, Kunnatur B Koteshwara, Meka Sreenivasa Reddy, Srinivas Mutalik
AIM: Asenapine maleate (ASPM) is a newer antipsychotic drug available as a sublingual tablet in the market. EXPERIMENTAL: To investigate the pharmacokinetic and tissue distribution study of ASPM following oral administration in rats, reversed-phase HPLC method was developed and validated. RESULTS: ASPM was extracted from plasma and tissue matrix by liquid-liquid extraction technique and analyzed using mobile phase consisted of phosphate buffer pH 3...
July 24, 2017: Bioanalysis
journal
journal
42494
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"