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Italian Journal of Pediatrics

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https://www.readbyqxmd.com/read/27927221/a-randomized-clinical-trial-comparing-3-different-replacement-regimens-of-vitamin-d-in-clinically-asymptomatic-pediatrics-and-adolescents-with-vitamin-d-insufficiency
#1
Iman M Talaat, Naglaa M Kamal, Hamed A Alghamdi, Abdulla A Alharthi, Mohamed A Alshahrani
BACKGROUND: Pediatric and Adolescent populations both have special needs for vitamin D especially for growing bone. Inadequate vitamin D is defined as 25 (OH) D(25hydroxy vitamin D) < 30 ng/ml. METHODS: We conducted a randomized, controlled clinical trial from July 2014 over 1 year, aiming to assess the changes in 25 (OH) D and biochemical outcome on calcium and PTH(parathyroid hormone) using 3 different regimens of vitamin D replacement. Initial and 4 month 25 (OH) D, calcium, PTH and 12 month 25 (OH) D levels were assayed...
December 7, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27923378/congenital-cytomegalovirus-related-intestinal-malrotation-a-case-report
#2
Claudia Colomba, Mario Giuffrè, Simona La Placa, Antonio Cascio, Marcello Trizzino, Simona De Grazia, Giovanni Corsello
BACKGROUND: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. CASE PRESENTATION: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction...
December 7, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27906083/neonatal-diffusion-tensor-brain-imaging-predicts-later-motor-outcome-in-preterm-neonates-with-white-matter-abnormalities
#3
Do-Yeon Kim, Hyun-Kyung Park, Nam-Su Kim, Se-Jin Hwang, Hyun Ju Lee
BACKGROUND: White matter (WM) abnormalities associated with prematurity are one of the most important causes of neurological disability that involves spastic motor deficits in preterm newborns. This study aimed to evaluate regional microstructural changes in diffusion tensor imaging (DTI) associated with WM abnormalities. METHODS: We prospectively studied extremely low birth weight (ELBW; <1000 g) preterm infants who were admitted to the Neonatal Intensive Care Unit of Hanyang University Hospital between February 2011 and February 2014...
December 1, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27899160/physiopathology-of-vesico-ureteral-reflux
#4
REVIEW
Salvatore Arena, Roberta Iacona, Pietro Impellizzeri, Tiziana Russo, Lucia Marseglia, Eloisa Gitto, Carmelo Romeo
Vescico-Ureteral Reflux (VUR) is a common condition in childhood, caused by a congenital anomaly at the Vescico-Ureteral Junction (VUJ) level. It seems that the main cause could be an abnormal embryological development occurred during the early stage of fetal life.Refluxing ureteral endings show structural and functional anomalies: previous studies have shown a significant decrease in alfa actin, miosin and desmin contents as well as an high rate of atrophy and muscular degeneration with disorganized muscular fibres...
November 29, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27871331/association-of-dars-gene-polymorphisms-with-the-risk-of-isolated-ventricular-septal-defects-in-the-chinese-han-population
#5
Yu Feng, Runsen Chen, Xuming Mo
BACKGROUND: Ventricular septal defects (VSD) are the most common subtype of congenital heart defects (CHD) and are estimated to account for 20 to 30% of all cases of CHD. The etiology of isolated VSD remains poorly understood. Eight core aminoacyl-tRNA synthetases (ARSs) (EPRS, MARS, QARS, RARS, IARS, LARS, KARS, and DARS) combine with three nonenzymatic components to form a complex known as the multisynthetase complex (MSC). Four single nucleotide polymorphisms (SNPs) in EPRS have been reported to be associated with risks of CHD in Chinese populations...
November 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27871293/genetic-and-epigenetic-alterations-in-the-gnas-locus-and-clinical-consequences-in-pseudohypoparathyroidism-italian-common-healthcare-pathways-adoption
#6
L de Sanctis, F Giachero, G Mantovani, G Weber, M Salerno, G I Baroncelli, M F Elli, P Matarazzo, M Wasniewska, L Mazzanti, G Scirè, D Tessaris
BACKGROUND: Genetic and epigenetic alterations in the GNAS locus are responsible for the Gsα protein dysfunctions causing Pseudohypoparathyroidism (PHP) type Ia/c and Ib, respectively. For these heterogeneous diseases characterized by multiple hormone resistances and Albright's Hereditary Osteodystrophy (AHO) the current classification results inadequate because of the clinical overlap between molecular subtypes and a standard clinical approach is still missing. In the present paper several members of the Study Group Endocrine diseases due to altered function of Gsα protein of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) have reviewed and updated the clinical-molecular data of the largest case series of (epi)/genetically characterized AHO/PHP patients; they then produced a common healthcare pathway for patients with these disorders...
November 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27863530/performances-of-low-level-hospital-health-caregivers-after-a-neonatal-resuscitation-course
#7
Giuseppe De Bernardo, Desirée Sordino, Francesco Cavallin, Veronica Mardegan, Nicoletta Doglioni, Maria Luisa Tataranno, Daniele Trevisanuto
BACKGROUND: High fidelity simulation has been executed to allow the evaluation of technical and non-technical skills of health caregivers. Our objective was to assess technical and non-technical performances of low level hospitals health caregivers who attended a Neonatal Resuscitation course using high fidelity simulation in a standard-setting scenario. METHODS: Twenty-three volunteers were asked to manage a simple scenario (infant with secondary apnea) after the course...
November 18, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27855688/fatal-varicella-pneumonia-in-an-unvaccinated-child-with-down-syndrome-a-case-report
#8
Diletta Valentini, Simona Bianchi, Chiara Di Camillo, Anna Chiara Vittucci, Michaela Veronika Gonfiantini, Rita De Vito, Alberto Villani
BACKGROUND: Varicella is an acute infectious disease common during childhood. It has mostly an uncomplicated course in early childhood. Neverthless, it may result in severe complications, especially in particular age groups and clinical conditions. Down Syndrome represents a risk factor for developing complications, because of the frequent comorbidities and their immunodeficiency. CASE PRESENTATION: A 2-year-old white Caucasian female affected by Down Syndrome was referred to our hospital for cardiac arrest in course of varicella disease...
November 17, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27852289/serological-screening-for-celiac-disease-in-382-pre-schoolers-with-autism-spectrum-disorder
#9
Sara Calderoni, Elisa Santocchi, Teresa Del Bianco, Elena Brunori, Laura Caponi, Aldo Paolicchi, Francesca Fulceri, Margherita Prosperi, Antonio Narzisi, Angela Cosenza, Raffaella Tancredi, Filippo Muratori
BACKGROUND: Recent investigations suggest a possible common genetic background between Autism Spectrum Disorders (ASD) and Celiac Disease (CD). However, studies regarding this association are scarce and often limited by the small sample sizes and/or large heterogeneity among ASD groups in terms of demographic and clinical features. The present study aims to investigate the overall CD prevalence (biopsy proven-CD patients plus screening detected tTG and EMA positive cases) in a large population of pre-schoolers with ASD referred to a tertiary care University Hospital...
November 16, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27846912/factors-associated-with-active-commuting-to-school-by-bicycle-from-bogot%C3%A3-colombia-the-fuprecol-study
#10
Robinson Ramírez-Vélez, Cesar Augusto Beltrán, Jorge Enrique Correa-Bautista, Andres Vivas, Daniel Humberto Prieto-Benavidez, Javier Martínez-Torres, Héctor Reynaldo Triana-Reina, Emilio Villa-González, Antonio Garcia-Hermoso
BACKGROUND: Active commuting to school (ACS) can contribute to daily physical activity (PA) levels in children and adolescents. The aim of the study was to analyze the characteristics of active commuting to and from school by bicycle and to identify the factors associated with the use of bicycles for active commuting to school based in a sample of schoolchildren in Bogotá, Colombia. METHODS: A cross-sectional study was conducted in 8,057 children and adolescents...
November 15, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27821174/eosinophilic-esophagitis-after-congenital-diaphragmatic-hernia
#11
Amelia Licari, Riccardo Castagnoli, Gian Luigi Marseglia
BACKGROUND: Eosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflammation in EoE is primarily triggered by immune dysregulation secondary to allergic sensitization to dietary or aero-allergens. Recent studies have reported a higher prevalence of EoE in children with congenital gastrointestinal malformations, i.e. esophageal atresia and/or tracheoesophageal fistula...
November 8, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27814774/atopy-and-autoimmune-thyroid-diseases-melatonin-can-be-useful
#12
REVIEW
Gabriella D'Angelo, Lucia Marseglia, Sara Manti, Laura Colavita, Caterina Cuppari, Pietro Impellizzeri, Salvatore Arena, Teresa Arrigo, Carmelo Salpietro, Eloisa Gitto
Recently, there has been growing interest in the relationship between allergic and autoimmune diseases. Allergy and autoimmunity can be considered two potential outcomes of dysregulated immunity and analysis of literature data shows a strong positive association between a history of Th2-mediated allergic disorders and Th1-mediated autoimmune disorders.Autoimmune thyroid diseases are the most common of all autoimmune pathological conditions.Currently, the mechanisms explaining an association among atopy, autoimmunity, and thyroid diseases are not fully understood...
November 4, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27809913/long-term-safety-and-efficacy-of-omnitrope%C3%A2-a-somatropin-biosimilar-in-children-requiring-growth-hormone-treatment-italian-interim-analysis-of-the-patro-children-study
#13
Lorenzo Iughetti, Gianluca Tornese, Maria Elisabeth Street, Flavia Napoli, Claudia Giavoli, Franco Antoniazzi, Stefano Stagi, Caterina Luongo, Sara Azzolini, Letizia Ragusa, Gianni Bona, Clara Zecchino, Tommaso Aversa, Luca Persani, Laura Guazzarotti, Emiliano Zecchi, Alberto Pietropoli, Stefano Zucchini
BACKGROUND: PATRO Children is an ongoing observational, longitudinal, non-interventional, global post-marketing surveillance study, which is investigating the long-term safety and effectiveness of Omnitrope®, a somatropin biosimilar to Genotropin®, in children with growth disturbances. The primary endpoint of PATRO Children is long-term safety and the secondary endpoint is effectiveness, which is assessed by analysing auxological data such as height (HSDS) and height velocity (HVSDS) standard deviation scores...
November 3, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27809881/norovirus-in-benign-convulsions-with-mild-gastroenteritis
#14
Gun-Ha Kim, Jung Hye Byeon, Deog-Yong Lee, Hyun Ju Jeong, Baik-Lin Eun
BACKGROUND: Benign convulsions with gastroenteritis (CwG) are defined as afebrile convulsions accompanying symptoms of gastroenteritis without evidence of laboratory derangement. Although the main pathogen has been known as rotavirus, since the introduction of rotavirus vaccine, associated viruses with CwG may have changed. Thus, we evaluated the viral association of CwG for patients admitting for recent 2.5 years. METHODS: All patients hospitalized for CwG between November 2012 and May 2015 were included in our study...
November 3, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27806720/kawasaki-disease-in-sicily-clinical-description-and-markers-of-disease-severity
#15
Maria Cristina Maggio, Giovanni Corsello, Eugenia Prinzi, Rolando Cimaz
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. METHODS: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks, and at 1 year after the onset of the illness...
November 2, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27769316/neurodevelopmental-profile-in-angelman-syndrome-more-than-low-intelligence-quotient
#16
S Micheletti, F Palestra, P Martelli, P Accorsi, J Galli, L Giordano, V Trebeschi, E Fazzi
BACKGROUND: Angelman Syndrome (AS) is a rare neurodevelopment disorder resulting from deficient expression or function of the maternally inherited allele of UBE3A gene. The aim of the study is to attempt at providing a detailed definition of neurodevelopmental profile in AS, with particular regard to motor, cognitive, communicative, behavioural and neurovisual, features by using standardized instruments. METHOD: A total of ten subjects aged from 5 to 11 years (4 males and 6 females) with molecular confirmed diagnosis of AS (7 15q11...
October 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27716328/cardiorespiratory-fitness-a-comparison-between-children-with-renal-transplantation-and-children-with-congenital-solitary-functioning-kidney
#17
Riccardo Lubrano, Giancarlo Tancredi, Raffaele Falsaperla, Marco Elli
Children with end-stage renal disease are known to have a cardiorespiratory fitness significantly reduced. This is considered to be an independent index predictive of mortality mainly due to cardiovascular accidents. The effects of renal transplantation on cardiorespiratory fitness are incompletely known. We compared the maximal oxygen uptake (VO2 max) of children with a functioning renal transplant with that of children with congenital solitary functioning kidney, taking into consideration also the amount of weekly sport activity...
October 6, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27677340/intussusception-hospitalizations-incidence-in-the-pediatric-population-in-italy-a-nationwide-cross-sectional-study
#18
Francesco Trotta, Roberto Da Cas, Antonino Bella, Carmela Santuccio, Stefania Salmaso
BACKGROUND: Study to investigate the intussusception incidence background in the pediatric population and its temporal trend in Italy. METHODS: A cross-sectional study was conducted on the pediatric population aged 0 to 15 years, in the period 1 January 2002 to 31 December 2012. Intussusception cases were identified using the national hospital discharge database. The annual intussusception incidence, the incidence rate ratios (IRRs) and the related 95 % confidence Intervals (CI) were calculated...
September 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27670687/peripheral-quantitative-computed-tomography-pqct-for-the-assessment-of-bone-strength-in-most-of-bone-affecting-conditions-in-developmental-age-a-review
#19
Stefano Stagi, Loredana Cavalli, Tiziana Cavalli, Maurizio de Martino, Maria Luisa Brandi
Peripheral quantitative computed tomography provides an automatical scan analysis of trabecular and cortical bone compartments, calculating not only their bone mineral density (BMD), but also bone geometrical parameters, such as marrow and cortical Cross-Sectional Area (CSA), Cortical Thickness (CoTh), both periosteal and endosteal circumference, as well as biomechanical parameters like Cross-Sectional Moment of Inertia (CSMI), a measure of bending, polar moment of inertia, indicating bone strength in torsion, and Strength Strain Index (SSI)...
September 26, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27644948/idiopathic-pulmonary-haemosiderosis-in-paediatric-patients-how-to-make-an-early-diagnosis
#20
Luca Castellazzi, Maria Francesca Patria, Gemma Frati, Andrea Alessandro Esposito, Susanna Esposito
BACKGROUND: Idiopathic pulmonary haemosiderosis (IPH) is a rare but potentially lethal condition in paediatric patients. This condition is considered an immune-mediated disorder, but its pathogenesis is still unknown. Idiopathic pulmonary haemosiderosis is characterized by the classical triad of haemoptysis, iron-deficiency anaemia, and diffuse parenchymal consolidation on chest radiology. Unfortunately, this triad of signs is not frequent in children at the onset of this disease, resulting in a delay in diagnosis and a negative outcome...
September 20, 2016: Italian Journal of Pediatrics
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