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Italian Journal of Pediatrics

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https://www.readbyqxmd.com/read/29025431/specific-ige-and-skin-prick-tests-to-diagnose-allergy-to-fresh-and-baked-cow-s-milk-according-to-age-a-systematic-review
#1
REVIEW
Barbara Cuomo, Giovanni Cosimo Indirli, Annamaria Bianchi, Stefania Arasi, Davide Caimmi, Arianna Dondi, Stefania La Grutta, Valentina Panetta, Maria Carmen Verga, Mauro Calvani
BACKGROUND: The diagnosis of IgE-mediated cow's milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often causing positive results in non-allergic subjects. Thus, oral food challenge is still the gold standard test for diagnosis, though being expensive, time-consuming and possibly at risk for severe allergic reactions. AIM: The aim of the present study was to perform a systematic review of the studies that have so far analyzed the positive predictive values for sIgE and SPT in the diagnosis of allergy to fresh and baked cow's milk according to age, and to identify possible cut-offs that may be useful in clinical practice...
October 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29025428/compound-heterozygosity-for-two-ghr-missense-mutations-in-a-patient-affected-by-laron-syndrome-a-case-report
#2
Stefania Moia, Daniele Tessaris, Silvia Einaudi, Luisa de Sanctis, Gianni Bona, Simonetta Bellone, Flavia Prodam
BACKGROUND: Mutations localized in the Growth Hormone Receptor (GHR) gene are often associated with the pathogenesis of Laron Syndrome, an autosomal recessive hereditary disorder characterized by severe growth retardation. Biochemically, patients present normal to high circulating GH levels, in presence of very low or undetectable IGF-I levels, which do not rise after rhGH treatment. CASE PRESENTATION: We describe the case of a 3.8 years old girl with symmetrical short stature (-3...
October 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29017528/first-case-of-mycobacterium-marseillense-lymphadenitis-in-a-child
#3
A Azzali, C Montagnani, M T Simonetti, G Spinelli, M de Martino, L Galli
BACKGROUND: Nontuberculous mycobacteria (NTM) are pathogens that commonly affect the paediatric population and its most frequent manifestation is a cervicofacial lymphadenopathy. With the improvement of technologies, new species have been recently identified. CASE PRESENTATION: We report the first case of NMT lymphadenitis in a child caused by Mycobacterium marseillense, a newly described species belonging to Mycobacterium avium complex. CONCLUSIONS: Improving the identification of these newly discovered mycobacteria, further information will be available about their clinical involvement and their best treatment...
October 10, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28985750/childhood-diarrheal-morbidity-and-sanitation-predictors-in-a-nomadic-community
#4
Bikes Destaw Bitew, Wondwoson Woldu, Zemichael Gizaw
BACKGROUND: Diarrhea remains a leading killer of young children on the globe despite the availability of simple and effective solutions to prevent and control it. The disease is more prevalent among under - five children (U5C) in the developing world due to lack of sanitation. A child dies every 15 s from diarrheal disease caused largely by poor sanitation. Nearly 90% of diarrheal disease is attributed to inadequate sanitation. Even though, the health burden of diarrheal disease is widely recognized at global level, its prevalence and sanitation predictors among a nomadic population of Ethiopia are not researched...
October 6, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28969661/object-permanence-and-the-development-of-attention-capacity-in-preterm-and-term-infants-an-eye-tracking-study
#5
Hokyoung Ryu, Garam Han, Jaeran Choi, Hyun-Kyung Park, Mi Jung Kim, Dong-Hyun Ahn, Hyun Ju Lee
No abstract text is available yet for this article.
October 2, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28962626/efficacy-and-usability-of-a-novel-nebulizer-targeting-both-upper-and-lower-airways
#6
Daniela Posa, Antonio Pizzulli, Petra Wagner, Serena Perna, Stephanie Hofmaier, Paolo Maria Matricardi, Susanne Lau
BACKGROUND: Upper and lower airways diseases share in part their pathogenic mechanisms and frequently occur simultaneously as "United Airway Disease." Local treatment with nebulizers delivers anti-symptomatic drugs in either the upper or the lower airways, according to the particle size generated by the nebulizer. To our knowledge, no nebulizer combines both application ways. The aim of this study is to test the efficacy and usability of a new nebulizer (OMRON A3 complete), generating aerosols with particles diameters of 2-4...
September 29, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28946922/nbas-mutations-cause-acute-liver-failure-when-acetaminophen-is-not-a-culprit
#7
Pier Luigi Calvo, Francesco Tandoi, Tobias B Haak, Andrea Brunati, Michele Pinon, Dominic Dell Olio, Renato Romagnoli, Marco Spada
BACKGROUND: Pediatric acute-liver-failure due to acetaminophen (APAP) administration at therapeutic dosage is rare, while viral infections and metabolic defects are the prevalent causes. Yet, as acetaminophen is routinely used in febrile illnesses, it may be mistakenly held responsible for the acute liver damage. CASE PRESENTATION: An 11 month old boy had been on acetaminophen for 10 days (total dose 720 mg = 72 mg/kg) when he developed acute-liver-failure with encephalopathy...
September 25, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28938886/congenital-hypothyroidism-due-to-ectopic-sublingual-thyroid-gland-in-prader-willi-syndrome-a-case-report
#8
Sarah Bocchini, Danilo Fintini, Graziano Grugni, Arianna Boiani, Alessio Convertino, Antonino Crinò
BACKGROUND: Thyroid gland disorders are variably associated with Prader-Willi syndrome (PWS). Many of the clinical features in newborns with PWS are similar to those found in congenital hypothyroidism (CH). CASE PRESENTATION: We report a case of a girl with CH and PWS. At the age of 9 months CH caused by an ectopic sublingual thyroid was diagnosed, and hormone replacement therapy was started. In spite of this treatment a decrease in growth velocity, weight excess and delayed development were observed...
September 22, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28934988/iron-deficiency-parameters-in-autism-spectrum-disorder-clinical-correlates-and-associated-factors
#9
Serkan Gunes, Ozalp Ekinci, Tanju Celik
BACKGROUND: High prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) has been reported in children with autism spectrum disorder (ASD). However, there is a limited number of studies about the association between iron deficiency parameters and clinical symptoms of ASD. This study aims to compare hemoglobin, hematocrit, iron, ferritin, MCV, and RDW levels between ASD patients and healthy controls and to investigate the correlation between these values and clinical symptoms of ASD...
September 21, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28934973/liver-chemistry-in-new-onset-henoch-sch%C3%A3-nlein-syndrome
#10
Giulia Rosti, Gregorio P Milani, Emanuela A Laicini, Emilio F Fossali, Mario G Bianchetti
BACKGROUND: Henoch-Schönlein syndrome is a systemic small-vessel leukocytoclastic vasculitis that usually present with cutaneous, gastrointestinal, articular and renal manifestations. Little is known on liver involvement in this syndrome. This study investigated liver chemistry and creatine kinase in Henoch-Schönlein children. CASE PRESENTATION: Alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, lactate dehydrogenase, total bilirubin, prothrombin time and creatine kinase were assessed in 75 consecutive pediatric patients (41 boys and 34 girls aged from 2...
September 21, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28931434/long-term-outcome-of-autistic-spectrum-disorder-a-retrospective-case-study-in-a-southern-italian-region
#11
Francesca Felicia Operto, Federica Martino, Annalisa Rinaldi, Angelo Cerracchio, Giovanni Salvati, Mariano Orza, Claudia Lembo, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Giovanni Farello, Giangennaro Coppola
BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, characterized by impaired social communication and restricted and repetitive behaviours, as well as associated features including intellectual disability and impaired sensorimotor function. Despite a growing interest in this devastating disorder for families and young parents, there are no certainties as regards its aetiology, although a significant genetic background is considered to be important. Since there is little information about the social adaptation and quality of life of patients with Autism Spectrum Disorder, we decided to study and evaluate the long-term outcome and quality of life in a sample of children, adolescent and young adults...
September 20, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28931415/newborn-hearing-screening-protocol-in-tuscany-region
#12
LETTER
Stefano Berrettini, Paolo Ghirri, Francesco Lazzerini, Giovanni Lenzi, Francesca Forli
BACKGROUND: Newborn hearing screening has to be considered the first step of a program for the identification, diagnosis, treatment and habilitation/rehabilitation of children with hearing impairment. MAIN PART: In Tuscany Region of Italy, the universal newborn hearing screening is mandatory since november 2007. The first guidelines for the execution of the screening have been released in June 2008; then many other Italian regions partially or totally adopted these guidelines...
September 20, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28931400/conduct-disorders-and-psychopathy-in-children-and-adolescents-aetiology-clinical-presentation-and-treatment-strategies-of-callous-unemotional-traits
#13
REVIEW
Simone Pisano, Pietro Muratori, Chiara Gorga, Valentina Levantini, Raffaella Iuliano, Gennaro Catone, Giangennaro Coppola, Annarita Milone, Gabriele Masi
Conduct Disorder (CD) is a psychiatric diagnosis characterized by a repetitive and persistent pattern of behaviour in which the basic rights of others and major age-appropriate social norms or rules are violated. Callous Unemotional (CU) traits are a meaningful specifier in subtyping CD for more severe antisocial and aggressive behaviours in adult psychopathology; they represent the affective dimension of adult psychopathy, but they can be also detected in childhood and adolescence. The CU traits include lack of empathy, sense of guilt and shallow emotion, and their characterization in youth can improve our diagnostic, prognostic and therapeutic abilities...
September 20, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#14
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915901/possible-effects-of-an-early-diagnosis-and-treatment-in-patients-with-growth-hormone-deficiency-the-state-of-art
#15
REVIEW
Stefano Stagi, Perla Scalini, Giovanni Farello, Alberto Verrotti
Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28899399/a-comparison-of-blood-stream-infections-with-extended-spectrum-beta-lactamase-producing-and-non-producing-klebsiella-pneumoniae-in-pediatric-patients
#16
Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Eda Karadag Oncel, Asiye Bıcakcigil, Banu Sancak, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. METHODS: A retrospective review of patients younger than 18 years-old with blood stream infection caused by K...
September 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28874171/long-term-treatment-with-low-dose-medicine-in-chronic-childhood-eczema-a-double-blind-two-stage-randomized-control-trial
#17
R Carello, L Ricottini, V Miranda, P Panei, L Rocchi, R Arcieri, E Galli
BACKGROUND: The efficacy of low-dose medicine (LDM) in childhood mild/moderate eczema is not known. We conducted a double-blind, two-stage, randomized, placebo-controlled clinical trial, lasting 23 months, to address this issue. METHOD: Eighty children with chronic mild/moderate eczema were randomly allocated to Group A (placebo) or Group B (treatment group; Galium-Heel®, a low-dose multicomponent medicine based upon natural substances; Guna-Interleukin 12 and Guna-Interferon-γ administered twice a day for six non-consecutive months for each stage)...
September 6, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28870218/respiratory-problems-in-children-with-esophageal-atresia-and-tracheoesophageal-fistula
#18
Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall'Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero, Renato Cutrera
BACKGROUND: Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to describe the clinical findings of a large group of children with EA and TEF surgically corrected and the instrumental investigation to which they have undergone in order to better understand the patient's needs and harmonize the care. METHODS: A retrospective data collection was performed on 105 children with EA and TEF followed at Department of Pediatric Medicine of Bambino Gesù Children's Hospital (Rome, Italy) between 2010 and 2015...
September 5, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28854953/humanization-of-pediatric-care-in-the-world-focus-and-review-of-existing-models-and-measurement-tools
#19
REVIEW
Marina Tripodi, Maria Anna Siano, Claudia Mandato, Anna Giulia Elena De Anseris, Paolo Quitadamo, Salvatore Guercio Nuzio, Claudia Viggiano, Francesco Fasolino, Annalisa Bellopede, Maria Annunziata, Grazia Massa, Francesco Maria Pepe, Maria De Chiara, Paolo Siani, Pietro Vajro
BACKGROUND: The term "humanization" indicates the process by which people try to make something more human and civilized, more in line with what is believed to be the human nature. The humanization of care is an important and not yet a well-defined issue which includes a wide range of aspects related to the approach to the patient and care modalities. In pediatrics, the humanization concept is even vaguer due to the dual involvement of both the child and his/her family and by the existence of multiple proposed models...
August 30, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28830498/validation-of-the-italian-version-of-the-non-communicating-children-s-pain-checklist-postoperative-version
#20
C Zanchi, M Massaro, G Ferrara, M Montico, F D'Osualdo, R Rutigliano, A Taddio, L Vecchi Brumatti, G Cozzi, E Barbi
BACKGROUND: This study evaluated the validity and reliability of the Italian version of the Non-Communicating Children's Pain Checklist-Postoperative version (I-NCCPC-PV). METHODS: The original NCCPC-PV version was translated into Italian following the guidelines for "the translation, adaptation, and validation of instruments or scales for cross-cultural healthcare research". We tested the Italian NCCPC-PV version (I-NCCPC-PV) in 40 children (3-18 years of age) with severe to profound Intellectual Disability and no verbal communication...
August 22, 2017: Italian Journal of Pediatrics
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