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Cancer Epidemiology

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https://www.readbyqxmd.com/read/29049937/risk-of-cardiovascular-disease-among-women-with-endometrial-cancer-compared-to-cancer-free-women-in-the-women-s-health-initiative
#1
Ashley S Felix, Amy Lehman, Randi E Foraker, Michelle J Naughton, Julie K Bower, Lewis Kuller, Gloria E Sarto, Marcia L Stefanick, Linda Van Horn, Rebecca D Jackson, Electra D Paskett
BACKGROUND: The majority of women diagnosed with endometrial cancer (EC) have low cancer-specific mortality; however, a high prevalence of cardiovascular disease (CVD) risk factors places EC patients at high risk of developing CVD. In the Women's Health Initiative (WHI), we assessed the hypothesis that CVD risk was higher among women who developed EC compared with women who did not develop EC. METHODS: We compared the incidence of fatal and non-fatal CVD events among 1,179 women who developed Type I EC, 211 women who developed Type II EC, and 92,217 women who did not develop EC...
October 16, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29040965/distribution-of-cancer-mortality-rates-by-province-in-south-africa
#2
Felix Made, Kerry Wilson, Ruxana Jina, Nonhlanhla Tlotleng, Samantha Jack, Vusi Ntlebi, Tahira Kootbodien
INTRODUCTION: Cancer mortality rates are expected to increase in developing countries. Cancer mortality rates by province remain largely unreported in South Africa. This study described the 2014 age standardised cancer mortality rates by province in South Africa, to provide insight for strategic interventions and advocacy. METHODS: 2014 deaths data were retrieved from Statistics South Africa. Deaths from cancer were extracted using 10th International Classification of Diseases (ICD) codes for cancer (C00-C97)...
October 14, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29035744/a-systematic-review-of-instrumental-variable-analyses-using-geographic-region-as-an-instrument
#3
Emily A Vertosick, Melissa Assel, Andrew J Vickers
BACKGROUND: Instrumental variables analysis is a methodology to mitigate the effects of measured and unmeasured confounding in observational studies of treatment effects. Geographic area is increasingly used as an instrument. METHODS: We conducted a literature review to determine the properties of geographic area in studies of cancer treatments. We identified cancer studies performed in the United States which incorporated instrumental variable analysis with area-wide treatment rate within a geographic region as the instrument...
October 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29032321/acne-in-late-adolescence-is-not-associated-with-a-raised-risk-of-subsequent-malignant-melanoma-among-men
#4
Teresa Mota Garcia, Ayako Hiyoshi, Ruzan Udumyan, Hugo Sjöqvist, Katja Fall, Scott Montgomery
BACKGROUND: To evaluate the association of acne in late adolescence with the risk for subsequent malignant melanoma (MM) in men. METHODS: Swedish register-based cohort study of 242,096 males born between 1952 and 1956, who took part in compulsory assessments for Swedish military conscription in late adolescence between 1969 and 1975, with subsequent diagnoses of MM (n=1,058) up to December 31, 2009. Covariates included measures of childhood circumstances and information from adolescence on presence of acne, physical fitness, cognitive function, body mass index (BMI), and a summary of diagnoses...
October 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29032320/methodological-issues-of-assessing-the-risk-of-a-second-cancer-occurring-in-the-same-site-as-a-first-cancer-using-registry-data
#5
Jérémie Jégu, Marie Moitry, Simona Bara, Brigitte Trétarre, Anne-Valérie Guizard, Anne-Sophie Woronoff, Laetitia Daubisse-Marliac, Véronique Bouvier, Xavier Troussard, Marc Colonna, Delphine Klein, Bénédicte Lapôtre-Ledoux, Michel Velten
OBJECTIVE: To present methodological issues that can arise with the assessment of the risk of a second primary cancer (SPC) occurring in the same site as a first cancer using registry data. MATERIAL AND METHODS: Data from ten French cancer registries were used, including data for patients with a first prostate cancer (in males), breast cancer (in females), and colon, lung and kidney cancer (in both sexes) diagnosed between 1989 and 2004. Standardized incidence ratios (SIRs) of SPC were computed by excluding, or not, the risk of an SPC at the same site...
October 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29032319/peri-operative-blood-transfusion-for-resected-colon-cancer-practice-patterns-and-outcomes-in-a-population-based-study
#6
Sunil V Patel, Kelly E Brennan, Sulaiman Nanji, Safiya Karim, Shaila Merchant, Christopher M Booth
BACKGROUND & OBJECTIVES: Literature suggests that peri-operative blood transfusion among patients with resected colon cancer may be associated with inferior long-term survival. The study objective was to characterize this association in our population. METHODS: This is a retrospective cohort study using the population-based Ontario Cancer Registry (2002-2008). Pathology reports were obtained for a 25% random sample of all cases and constituted the study population...
October 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28992568/self-rated-health-and-associated-factors-in-elderly-patients-with-non-hodgkin-lymphoma
#7
Lívia Maria Santiago, Daniel Richard Mercante, Inês Echenique Mattos
BACKGROUND: Self-rated health is a useful indicator for understanding health issues in elderly populations and considered to be a predictor of adverse health outcomes in this group. This study aims to identify factors associated with self-rated health in elderly people with non-Hodgkin's lymphoma. METHODS: Cross-sectional study performed at a cancer referral hospital in Rio de Janeiro, Brazil, included 162 patients, aged 60 or more years. All patients received a Multidimensional Geriatric Assessment, including seven health dimensions, and socio-demographic, epidemiological and it were collected clinical data...
October 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28992567/conditional-survival-of-pediatric-adolescent-and-young-adult-soft-tissue-sarcoma-and-bone-tumor-patients
#8
Judy Y Ou, Holly Spraker-Perlman, Andrew C Dietz, Rochelle R Smits-Seemann, Sapna Kaul, Anne C Kirchhoff
BACKGROUND: Survival estimates for soft tissue sarcomas (STS) and malignant bone tumors (BT) diagnosed in pediatric, adolescent, and young adult patients are not easily available. We present survival estimates based on a patient having survived a defined period of time (conditional survival). Conditional survival estimates for the short-term were calculated for patients from diagnosis to the first five years after diagnosis and for patients surviving in the long-term (up to 20 years after diagnosis)...
October 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28987964/meta-analysis-of-the-clinicopathological-characteristics-and-peri-operative-outcomes-of-colorectal-cancer-in-obese-patients
#9
Ailin C Rogers, Guy S Handelman, J Gemma Solon, Deborah A McNamara, Joseph Deasy, John P Burke
BACKGROUND: The effect of obesity on the clinicopathological characteristics of colorectal cancer (CRC) has not been clearly characterized. This meta-analysis assesses the pathological and perioperative outcomes of obese patients undergoing surgical resection for CRC. METHODS: Meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases were searched for studies reporting outcomes for obese and non-obese patients undergoing primary CRC resection, based on body-mass index measurement...
October 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28987963/improving-cancer-patient-emergency-room-utilization-a-new-jersey-state-assessment
#10
Anthony J Scholer, Omar M Mahmoud, Debopyria Ghosh, Jacob Schwartzman, Mohammed Farooq, Javier Cabrera, Robert Wieder, Nabil R Adam, Ravi J Chokshi
INTRODUCTION: Due to its increasing incidence and its major contribution to healthcare costs, cancer is a major public health problem in the United States. The impact across different services is not well documented and utilization of emergency departments (ED) by cancer patients is not well characterized. The aim of our study was to identify factors that can be addressed to improve the appropriate delivery of quality cancer care thereby reducing ED utilization, decreasing hospitalizations and reducing the related healthcare costs...
October 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28968558/associations-between-oral-hygiene-habits-diet-tobacco-and-alcohol-and-risk-of-oral-cancer-a-case-control-study-from-india
#11
Bhawna Gupta, Freddie Bray, Narinder Kumar, Newell W Johnson
OBJECTIVE: This study examines the association between the incidence of oral cancer in India and oral hygiene habits, diet, chewing and smoking tobacco, and drinking alcohol. We also assessed the effects of oral hygiene habits with oral cancer risk among chewers versus never chewers. METHODS: A hospital-based case-control study was conducted in Pune, India, based on face-to-face interviews, anthropometry, and intra-oral examinations conducted for 187 oral cancer cases and 240 controls...
September 29, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28963913/trends-in-prescribing-systemic-treatment-and-overall-survival-for-non-small-cell-lung-cancer-stage-iiib-iv-in-the-netherlands-2008-2012
#12
Bas J M Peters, Christine M Cramer-Vd Welle, Arthur A J Smit, Franz M N H Schramel, Ewoudt M W van de Garde
BACKGROUND: The present study aims to give a detailed overview of day-to-day practice in the systemic treatment of NSCLC stage IIIB/IV and its clinical outcomes in six large teaching hospitals in the Netherlands in the period 2008-2012. METHODS: A retrospective observational cohort study was conducted in the Care for Outcome registry. Patients diagnosed with stage IIIB/IV NSCLC were included and drug data were collected. Outcomes included percentage of patients treated with systemic treatment, percentage of different first line treatment options, survival, and number and percentage of switches, dose reductions (<80% of the initial dose), and early discontinuation (<4 cycles)...
September 27, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28915472/-assessing-the-methodological-quality-of-systematic-reviews-in-radiation-oncology-a-systematic-review
#13
REVIEW
Haroon Hasan, Taaha Muhammed, Jennifer Yu, Kelsi Taguchi, Osama A Samargandi, A Fuchsia Howard, Andrea C Lo, Robert Olson, Karen Goddard
OBJECTIVE: The objective of our study was to evaluate the methodological quality of systematic reviews and meta-analyses in Radiation Oncology. METHODS: A systematic literature search was conducted for all eligible systematic reviews and meta-analyses in Radiation Oncology from 1966 to 2015. Methodological characteristics were abstracted from all works that satisfied the inclusion criteria and quality was assessed using the critical appraisal tool, AMSTAR. Regression analyses were performed to determine factors associated with a higher score of quality...
September 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28910695/mds-classification-is-improving-in-an-era-of-the-who-2016-criteria-of-mds-a-population-based-analysis-among-9159-mds-patients-diagnosed-in-the-netherlands
#14
Avinash G Dinmohamed, Otto Visser, Eduardus F M Posthuma, Peter C Huijgens, Pieter Sonneveld, Arjan A van de Loosdrecht, Mojca Jongen-Lavrencic
BACKGROUND: Morphologic and cytogenetic assessments are required to characterize diagnostic and prognostic features of myelodysplastic syndromes (MDS). We assessed whether these assessments were performed among newly diagnosed MDS patients in the Netherlands. METHODS: MDS cases were retrieved from the nationwide Netherlands Cancer Registry (N=9159; period 2001-2014) and the regional PHAROS MDS registry (N=676; period 2008-2011). RESULTS: The proportion of unclassified MDS decreased from 58% in 2001 to 13% in 2014...
September 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28910694/an-epidemiologic-perspective-on-the-stem-cell-hypothesis-in-human-carcinogenesis
#15
REVIEW
David Schottenfeld
BACKGROUND: Tomasetti and Vogelstein have hypothesized that the patterns of cancer incidence in various cells and tissues are highly correlated with the estimated lifetime number of stem cell divisions. The authors reviewed the risks in tissues of 17 types of cancer from the United States and 69 additional countries. Positive correlations were observed consistently between the tissue - specific cancer incidence and the estimated lifetime number of stem cell divisions. The authors concluded that approximately two-thirds of global cancer incidence may be attributed to random DNA replication errors...
September 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28898817/long-term-trends-in-incidence-and-survival-of-penile-cancer-in-france
#16
Laetitia Daubisse-Marliac, Marc Colonna, Brigitte Trétarre, Gautier Defossez, Florence Molinié, Karine Jéhannin-Ligier, Emilie Marrer, Pascale Grosclaude
BACKGROUND: Penile cancer is rare, and few population-based studies have described changes in time trend. This study aims to determine whether there has been an evolution in incidence and survival of penile cancer over time in France. METHODS: Rates of age world-standardized incidence (ASRW) and net survival (NS) between 1989 and 2011 were calculated using data from 16 French cancer registries. Time trend incidence and survival analysis were confined to the eight registries operating throughout the full period...
September 9, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28888185/helicobacter-pylori-serological-biomarkers-of-gastric-cancer-risk-in-the-mcc-spain-case-control-study
#17
Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Angelika Michel, Beatriz Romero, Virginia Lope, Michael Pawlita, Tania Fernández-Villa, Victor Moreno, Vicente Martín, Martina Willhauck-Fleckenstein, Gonzalo López-Abente, Jesús Castilla, Guillermo Fernández-Tardón, Trinidad Dierssen-Sotos, Miguel Santibáñez, Rosana Peiró, José Juan Jiménez-Moleón, Carmen Navarro, Gemma Castaño-Vinyals, Manolis Kogevinas, Marina Pollán, Silvia de Sanjosé, Rosa Del Campo, Tim Waterboer, Nuria Aragonés
BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology...
September 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28866282/calcium-channel-blockers-and-breast-cancer-incidence-an-updated-systematic-review-and-meta-analysis-of-the-evidence
#18
REVIEW
Cameron M Wright, Rachael E Moorin, Enayet K Chowdhury, Bruno H Stricker, Christopher M Reid, Christobel M Saunders, Jeffery D Hughes
Controversy exists regarding the potential association between taking calcium channel blockers (CCBs) and the development of breast cancer. As a positive association would have important public health implications due to the widespread use of CCBs, this study aimed to incorporate new evidence to determine whether an association is likely to exist. We searched MEDLINE, EMBASE and the Cochrane Library to 28 June 2016 for relevant literature. References and citing articles were checked and authors contacted as necessary...
September 1, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28858687/clinical-epidemiology-of-tracheal-invasion-from-thyroid-cancer-in-japanese-population-functional-outcomes-and-effect-of-aging
#19
Yuji Kanazawa, Masato Takeuchi, Ichiro Tateya, Koichi Omori, Koji Kawakami
BACKGROUND: Although tracheal invasion from thyroid cancer is life-threatening, the epidemiology of its development remains unclear. This study aimed to determine the epidemiology (prevalence, incidence, and risk factors) and functional outcomes of tracheal invasion from thyroid cancer among Japanese patients who were eligible for full-layer tracheal resection. METHODS: Patients with thyroid cancer and with or without tracheal invasion were identified based on procedure codes using a large inpatient database that is maintained by a data vendor...
August 28, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28850934/association-between-the-neighborhood-obesogenic-environment-and-colorectal-cancer-risk-in-the-multiethnic-cohort
#20
Alison J Canchola, Salma Shariff-Marco, Juan Yang, Cheryl Albright, Andrew Hertz, Song-Yi Park, Yurii B Shvetsov, Kristine R Monroe, Loïc Le Marchand, Scarlett Lin Gomez, Lynne R Wilkens, Iona Cheng
BACKGROUND: Information on the role of the neighborhood environment and colorectal cancer risk is limited. We investigated the association between a comprehensive suite of possible obesogenic neighborhood attributes (socioeconomic status, population density, restaurant and retail food environments, numbers of recreational facilities and businesses, commute patterns, traffic density, and street connectivity) and colorectal cancer risk in the Multiethnic Cohort Study. METHODS: Among 81,197 eligible participants living in California (35,397 males and 45,800 females), 1973 incident cases (981 males and 992 females) of invasive colorectal cancer were identified between 1993 and 2010...
August 26, 2017: Cancer Epidemiology
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