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Cancer Epidemiology

Lu Zhang, Jessica King, Xiao-Cheng Wu, Mei-Chin Hsieh, Vivien W Chen, Qingzhao Yu, Elizabeth Fontham, Michelle Loch, Lori A Pollack, Tekeda Ferguson
BACKGROUND: The study aimed to examine racial/ethnic differences in chemotherapy utilization by breast cancer subtype. METHODS: Data on female non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic stage I-III breast cancer patients diagnosed in 2011 were obtained from a project to enhance population-based National Program of Cancer Registry data for Comparative Effectiveness Research. Hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) were used to classify subtypes: HR+/HER2-; HR+/HER2+; HR-/HER2-; and HR-/HER2 + ...
November 8, 2018: Cancer Epidemiology
Dipak B Ramkumar, Niveditta Ramkumar, Benjamin J Miller, Eric R Henderson
BACKGROUND: Ewing family of tumors (EFT) represents the second-most common primary bone malignancy in children and adolescents. Approximately 25% of patients have radiographically detectable metastatic disease at presentation and experience poorer five-year survival, yet risk factors for metastatic disease at presentation are poorly characterized. We sought to study patient characteristics associated with metastatic disease upon presentation for patients with EFT. METHODS: We identified EFT cases in the Surveillance, Epidemiology, and End Results Program (SEER) registry from 2004 to 2012...
November 6, 2018: Cancer Epidemiology
Samah Hayek, Rita Dichtiar, Tamy Shohat, Barbara Silverman, Anneke Ifrah, Lital Keinan Boker
OBJECTIVE: Although overall childhood cancer survival has improved, survivors may still have an elevated risk for second primary neoplasm (SPN) and excess mortality. The aim of the current study was to estimate the risks for SPN and mortality in childhood cancer survivors in Israel as compared to the general population. METHODS: All children aged 0-19 diagnosed with primary neoplasm between 1980-2007 who survived at least 5 years following diagnosis were included in the study...
November 3, 2018: Cancer Epidemiology
Li-Wei Zhang, Jin Li, Xin Cong, Xiao-Sheng Hu, Dan Li, Li-Ling Wu, Hong Hua, Guang-Yan Yu, Alexander Ross Kerr
BACKGROUND: Oral and oropharyngeal cancers are among the most common cancers globally. This study aimed to assess the incidence and mortality trends of oral and oropharyngeal cancers in China between 2005 and 2013. METHODS: Estimates of national trends of oral and oropharyngeal cancers were based on the data from Chinese Cancer Registry Annual Reports. The crude incidence rates of oral and oropharyngeal cancers between 2015 and 2035 were evaluated. The age-standardized rate was based on the world standard population...
November 2, 2018: Cancer Epidemiology
Christian Stock, Ute Mons, Hermann Brenner
BACKGROUND: Cancer incidence projections are of major interest for resource allocation in healthcare and medical research. Previous reports of cancer incidence projections have often been deterministic, i.e. lacking quantification of uncertainty. We project cancer incidence in Germany by applying an approach that allows for probabilistic interpretation of outcomes. MATERIAL AND METHODS: German cancer registry data from 1999 to 2013 are used to predict cancer incidence for 27 sites until the year 2030...
October 30, 2018: Cancer Epidemiology
R Dankner, L Keinan Boker, P Boffetta, R D Balicer, H Murad, A Berlin, L Olmer, N Agai, L S Freedman
AIMS: This population-based historical cohort study examined whether poor glycemic-control (i.e., high glucose and HbA1c blood levels) in patients with diabetes is associated with cancer-risk. METHODS: From a large healthcare database, patients aged 21-89 years, diagnosed with diabetes before January 2002 (prevalent) or during 2002-2010 (incident), were followed for cancer during 2004-2012 (excluding cancers diagnosed within the first 2 years since diabetes diagnosis)...
October 27, 2018: Cancer Epidemiology
Paola DiMarzio, Rita Peila, Oonagh Dowling, Dennis M Timony, Amrita Balgobind, Lucille N Lee, Karen M Kostroff, Gloria Y F Ho
BACKGROUND: Smoking and alcohol consumption are potential risk factors for breast cancer (BC) and may modify the risk of radiotherapy-associated second primary cancer (SPC) occurrence and total mortality. We explored the joint effect of smoking, or alcohol drinking, and radiotherapy on the risk of SPC and overall mortality among BC survivals. METHODS: We conducted a cancer registry-based study of 10,676 BC cases (stage 0-III) with data on smoking and alcohol consumption at time of diagnosis and clinical and therapeutics characteristics...
October 22, 2018: Cancer Epidemiology
Burak Kalin, Esther N Pijnappel, Michel van Gelder, Otto Visser, Arjan A van de Loosdrecht, Gert J Ossenkoppele, Jan J Cornelissen, Avinash G Dinmohamed, Mojca Jongen-Lavrencic
BACKGROUND: The paucity of population-based research indicates that the application of intensive chemotherapy (ICT) among elderly acute myeloid leukemia (AML) patients, as well as their accrual to randomized controlled trials (RCTs) remains low for several decades. Therefore, a contemporary, comprehensive apprehension on patient-, disease-, and treatment-specific characteristics of elderly AML patients at the population level can inform treatment choices and facilitate increased patient accrual in upcoming RCTs...
October 19, 2018: Cancer Epidemiology
Rūta Everatt, Birutė Intaitė
BACKGROUND: The aim of this study was to investigate time trends in cervical cancer mortality rates in Lithuania across age groups and time periods over a 30-year time span. METHODS: Data on numbers of deaths from cervical cancer during the period 1987-2016 were obtained from the WHO mortality database. Trends in age-standardised mortality rates (ASR, world standard), and age-specific rates were analysed by calculating annual percentage change (APC) using Joinpoint regression...
October 19, 2018: Cancer Epidemiology
Kunhwa Kim, Tong Han Chung, Carol J Etzel, Jinhyun Kim, Hyunjin Ryu, Dae Won Kim, Patrick Hwu, Wen-Jen Hwu, Sapna P Patel, Mei Liu, Kevin B Kim
BACKGROUND: Melanoma and renal-cell carcinoma (RCC) are known to be immunological neoplasms. Previous studies have shown increased risks in patients with melanoma of developing RCC and in those with RCC of developing melanoma. However, data regarding immunocompromised status in these patients are lacking. METHODS: We conducted a retrospective review of patients who had a diagnosis of melanoma and/or RCC. Using summary statistics, we calculated total person-years at risk for developing melanoma among patients with RCC and for developing RCC among patients with melanoma, and compared the results with the SEER data...
October 19, 2018: Cancer Epidemiology
Ulrik Deding, Christian Torp-Pedersen, Henrik Bøggild
BACKGROUND: Barriers such as language and literacy might complicate the participation procedure for immigrants in screening programs. We investigated the delivery of a suitable stool sample for participation in the Danish colorectal cancer screening by immigration background. METHODS: National administrative registers were used to link results of faecal blood screening with immigrant status, age, sex, education, income, and marital status. Univariate and multivariate logistic regression models were used to estimate the odds of submitting an ineligible sample...
October 13, 2018: Cancer Epidemiology
Baozhen Qiao, April A Austin, Maria J Schymura, Marilyn L Browne
BACKGROUND: Acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML) among DS children have been studied extensively using data from clinical trials or institutional reports. The purpose of this study was to link population-based cancer and birth defects data to evaluate characteristics and survival of children with acute leukemia according to the presence of DS or other birth defects. METHODS: ALL and AML cases diagnosed between 1983 and 2012 among children aged 0-14 years were obtained from the New York State Cancer Registry...
October 13, 2018: Cancer Epidemiology
Koen Degeling, Mira D Franken, Anne M May, Martijn G H van Oijen, Miriam Koopman, Cornelis J A Punt, Maarten J IJzerman, Hendrik Koffijberg
BACKGROUND: Individual patient data, e.g. from clinical trials, often need to be extrapolated or combined with additional evidence when assessing long-term impact in cost-effectiveness modeling studies. Different modeling methods can be used to represent the complex dynamics of clinical practice; the choice of which may impact cost-effectiveness outcomes. We compare the use of a previously designed cohort discrete-time state-transition model (DT-STM) with a discrete event simulation (DES) model...
October 11, 2018: Cancer Epidemiology
Areesha Alam, Archana Kumar
BACKGROUND: Treatment refusal or abandonment are among the major causes of the survival gap between developed and developing countries. METHODS: This retrospective observational study analyzed records of children aged <18 years with acute lymphoblastic leukemia (ALL) registered for treatment at a tertiary-care teaching hospital, North India, between 1995 and 2012. Children who refused or abandoned therapy were tracked, and reasons for refusal/abandonment were recorded by telephone interviews or by surface mail...
October 10, 2018: Cancer Epidemiology
Diana Menya, Margaret Oduor, Nicholas Kigen, Stephen K Maina, Fatma Some, Caroline Kibosia, David Chumba, Florence A Murgor, Rafael S Carel, Daniel R S Middleton, Behnoush Abebi-Ardekani, Joachim Schüz, Valerie A McCormack
BACKGROUND: Case-control studies remain an important study design for aetiologic research on cancer, particularly when cohorts are not available. In addition to the potential biases inherent in this design, conducting fieldwork in settings with weak health care and information systems for cancer, such as in sub Saharan Africa, confer additional challenges which we present here with the aim to share experience to guide future studies. METHODS: We undertook a hospital-based case-control study of squamous cell esophageal cancer at the Moi Teaching and Referral Hospital in Eldoret, West Kenya...
October 6, 2018: Cancer Epidemiology
M Colonna, O Boussari, A Cowppli-Bony, P Delafosse, G Romain, P Grosclaude, V Jooste
No abstract text is available yet for this article.
October 4, 2018: Cancer Epidemiology
Sisse Helle Njor, Lennart Friis-Hansen, Berit Andersen, Bo Søndergaard, Dorte Linnemann, Jens Christian Riis Jørgensen, Ole Roikjær, Morten Rasmussen
BACKGROUND: The Danish National Colorectal Cancer Screening Programme was implemented in March 2014 and is offered free of charge to all residents aged 50-74 years. The aim of this study is to compare performance indicators from the Danish National Colorectal Cancer Screening Programme to the recommendations from European Guidelines in order to assure the quality of the programme and to provide findings relevant to other population-based colorectal cancer screening programmes. METHODS: Based on data from the Danish Colorectal Cancer Screening Database, we evaluated all performance indicators for which the European Guidelines provided acceptable level, desirable level or the level from first screening rounds in population-based studies using FIT...
October 4, 2018: Cancer Epidemiology
Chanpreet S Arhi, Alex Bottle, Elaine M Burns, Jonathan M Clarke, Paul Aylin, Paul Ziprin, Ara Darzi
INTRODUCTION: The Clinical Practice Research Datalink (CPRD) is a large electronic dataset of primary care medical records. For the purpose of epidemiological studies, it is necessary to ensure accuracy and completeness of cancer diagnoses in CPRD. METHOD: Cases included had a colorectal, oesophagogastric (OG), breast, prostate or lung cancer diagnosis recorded in a least one of CPRD, Cancer Registry (CR) or Hospital Episodes Statistics(HES) between 2000 and 2013...
October 2, 2018: Cancer Epidemiology
Leolin Katsidzira, Ria Laubscher, Innocent T Gangaidzo, Rina Swart, Rudo Makunike-Mutasa, Tadios Manyanga, Sandie Thomson, Raj Ramesar, Jonathan A Matenga, Simbarashe Rusakaniko
BACKGROUND: The rising incidence of colorectal cancer in sub-Saharan Africa may be partly caused by changing dietary patterns. We sought to establish the association between dietary patterns and colorectal cancer in Zimbabwe. METHODS: One hundred colorectal cancer cases and 200 community-based controls were recruited. Data were collected using a food frequency questionnaire, and dietary patterns derived by principal component analysis. Generalised linear and logistic regression models were used to assess the associations between dietary patterns, participant characteristics and colorectal cancer...
October 1, 2018: Cancer Epidemiology
Sandar Tin Tin, Mark J McKeage, Prashannata Khwaounjoo, Aye Myat Thi, J Mark Elwood
BACKGROUND: Epidermal Growth Factor Receptor (EGFR) mutation testing is recommended for patients with non-squamous non-small cell lung cancer (NSCLC) but not all eligible patients get tested, which may bias the mutation prevalence estimated. This study aims to examine trends in the uptake of EGFR mutation testing in patients with non-squamous NSCLC in New Zealand; to develop a composite metric that quantifies the influences of demographic and clinico-pathological factors on the testing uptake; and to estimate the prevalence of EGFR mutation if all patients were tested...
September 29, 2018: Cancer Epidemiology
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