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Cancer Epidemiology

Pamela Minicozzi, Tiziana Cassetti, Claudia Vener, Milena Sant
BACKGROUND: Pancreatic (PC) and biliary tract (BTC) cancers have higher incidence and mortality in Europe than elsewhere. We analysed time-trends in PC/BTC incidence, mortality, and survival across Europe. Since the European standard population (ESP) was recently revised to better represent European age structure, we also assessed the effect of adopting the revised ESP to age-standardise incidence and mortality data. METHODS: We analysed PCs/BTCs (≥15 years) diagnosed in 2000-2007 and followed-up to end of 2008, in 29 European countries across five regions: UK/Ireland, and northern, central, southern, and eastern Europe...
May 16, 2018: Cancer Epidemiology
Noah C Peeri, Jordan H Creed, Gabriella M Anic, Reid C Thompson, Jeffrey J Olson, Renato V LaRocca, Sajeel A Chowdhary, John D Brockman, Travis A Gerke, L Burton Nabors, Kathleen M Egan
BACKGROUND: Selenium is an essential trace element obtained through diet that plays a critical role in DNA synthesis and protection from oxidative damage. Selenium intake and polymorphisms in selenoproteins have been linked to the risk of certain cancers though data for glioma are sparse. METHODS: In a case-control study of glioma, we examined the associations of selenium in toenails and genetic variants in the selenoenzyme pathway with the risk of glioma and patient survival...
May 16, 2018: Cancer Epidemiology
Angéline Galvin, Catherine Helmer, Gaëlle Coureau, Brice Amadeo, Pierre Joly, Camille Sabathé, Alain Monnereau, Isabelle Baldi, Muriel Rainfray, Pierre Soubeyran, Fleur Delva, Simone Mathoulin-Pélissier
INTRODUCTION: Several studies have reported disparities in the care management and survival of older cancer patients. The aim of our study was to identify determinants of treatment administration in this population of cancer patients aged over 65 years taking into account competing risks of death. METHODS: The INCAPAC study is a population-based study. Four cancer registries and three prospective cohort studies on older subjects (age ≥65 years) from Gironde, a French department, were merged to identify older cancer patients...
May 12, 2018: Cancer Epidemiology
Justin Xavier Moore, Tomi Akinyemiju, Alfred Bartolucci, Henry E Wang, John Waterbor, Russell Griffin
BACKGROUND: Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. METHODS: We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer...
May 11, 2018: Cancer Epidemiology
Ashley L Cole, Anna E Austin, Ryan P Hickson, Matthew S Dixon, Emma L Barber
Randomized trials outside the U.S. have found non-inferior survival for neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) for advanced ovarian cancer (AOC). However, these trials reported lower overall survival and lower rates of optimal debulking than U.S. studies, leading to questions about generalizability to U.S. practice, where aggressive debulking is more common. Consequently, comparative effectiveness in the U.S. remains controversial. We reviewed U.S. comparative effectiveness studies of NACT versus PDS for AOC...
May 11, 2018: Cancer Epidemiology
Ming Li, Stephen Morrell, Nicola Creighton, Hanna Tervonen, Hui You, David Roder, David Currow
BACKGROUND: Cancer survival has improved markedly in Australia for all ages but it is still lower in older patients. We hypothesize that the survival gap by age has increased. Our rationale is that treatment constraints in older people and potentially their limited participation in trials may have limited opportunities for survival gain. METHODS: Post-diagnostic five-year cancer-specific mortality rates were analysed by age group for cancers recorded on the NSW Cancer Registry...
May 11, 2018: Cancer Epidemiology
Rafael Alonso, Marion Piñeros, Mathieu Laversanne, Carina Musetti, Mariela Garau, Enrique Barrios, Freddie Bray
BACKGROUND: Uruguay, a country with one of the highest lung cancer rates worldwide, initiated a series of comprehensive anti-smoking measures in 2005. We assess the tobacco control policies in the context of cohort-driven lung cancer incidence trends over a 25-year period, providing baseline predictions to 2035. METHODS: Using data from the National Cancer Registry of Uruguay, an age-period-cohort analysis of trends 1990-2014 was performed. The NORDPRED package was used to predict the annual number of new cases of lung cancer and incidence rates up to 2035...
May 11, 2018: Cancer Epidemiology
Sofia Lourenço, Vibeke Berglund Gunge, Therese M-L Andersson, Camilla Liv Erthmann Andersen, Anne-Sofie Q Lund, Brian Køster, Gitte Laub Hansen
BACKGROUND: High red and processed meat intakes are associated with increased colorectal cancer (CRC) risk. The effect of eliminating or reducing red and processed meat consumption on CRC burden was not previously quantified in Denmark. The aim of this study was to calculate the possible effects of reductions in red and processed meat consumption on future CRC incidence in the Danish adult population. METHODS: Under six scenarios of prevalence exposure (meat consumption) the number of CRC cases in Denmark for a 30-year period (2016-2045) was estimated and compared to the projected number of CRCs if the prevalence of meat consumption remains constant...
May 9, 2018: Cancer Epidemiology
Marinho Marques, Estela Luz, Mateus Leal, João Vitor Oliveira, Rejane Patrício, Eduardo Martins Netto, Carlos Brites
BACKGROUND: HIV-infected patients are at a higher risk to develop malignancies than general population. Although AIDS-related malignancies are a common feature of late-stage disease, patients under successful antiretroviral therapy also have an increased risk for development of non-AIDS malignancies. OBJECTIVE: To compare the frequency and characteristics of adults HIV-infected patients and general population who died of malignancies in Bahia, Brazil from January 2000 to December 2010...
May 1, 2018: Cancer Epidemiology
Ana Ferro, Samantha Morais, Matteo Rota, Claudio Pelucchi, Paola Bertuccio, Rossella Bonzi, Carlotta Galeone, Zuo-Feng Zhang, Keitaro Matsuo, Hidemi Ito, Jinfu Hu, Kenneth C Johnson, Guo-Pei Yu, Domenico Palli, Monica Ferraroni, Joshua Muscat, Reza Malekzadeh, Weimin Ye, Huan Song, David Zaridze, Dmitry Maximovitch, Nerea Fernández de Larrea, Manolis Kogevinas, Jesus Vioque, Eva M Navarrete-Muñoz, Mohammadreza Pakseresht, Farhad Pourfarzi, Alicja Wolk, Nicola Orsini, Andrea Bellavia, Niclas Håkansson, Lina Mu, Roberta Pastorino, Robert C Kurtz, Mohammad H Derakhshan, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Carlo La Vecchia, Bárbara Peleteiro, Nuno Lunet
BACKGROUND: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. METHODS: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies...
May 1, 2018: Cancer Epidemiology
Xiangyang Wang, Weilan Cao, Chenguo Zheng, Wanle Hu, Changbao Liu
BACKGROUND: Marital status has been validated as an independent prognostic factor for survival in several cancer types, but is controversial in rectal cancer (RC). The objective of this study was to investigate the impact of marital status on the survival outcomes of patients with RC. METHODS: We extracted data of 27,498 eligible patients diagnosed with RC between 2004 and 2009 from the Surveillance, Epidemiology and End Results (SEER) database. Patients were categorized into married, never married, divorced/separated and widowed groups...
May 1, 2018: Cancer Epidemiology
Michele Marchioni, Sabrina S Harmouch, Sebastiano Nazzani, Marco Bandini, Felix Preisser, Zhe Tian, Anil Kapoor, Luca Cindolo, Alberto Briganti, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
AIM: To test the effect of African-American race on cancer specific mortality (CSM) in clear cell metastatic renal cell carcinoma (ccmRCC) and non-ccmRCC. PATIENTS AND METHODS: Within Surveillance, Epidemiology and End Results registry (2001-2014), we identified patients with ccmRCC and non-ccmRCC. We relied on propensity score (PS) matching to reduce the effect of inherent differences between African-American vs. Caucasian patients. After PS matching that included access to cytoreductive nephrectomy (CNT), cumulative incidence, competing-risks regression (CRR) models and landmark analyses tested the effect of race on CSM...
April 28, 2018: Cancer Epidemiology
Roy G P J de Jong, Paul J H L Peeters, Andrea M Burden, Marie L de Bruin, Harm R Haak, Ad A M Masclee, Frank de Vries, Maryska L G Janssen-Heijnen
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) have been shown to have higher incidences of liver, pancreatic, and colorectal cancer compared to non-diabetic individuals. Current evidence is conflicting for other gastrointestinal (GI) cancers. Therefore, we aimed to determine incidence rates (IRs) of all GI cancers in patients with and without T2DM. METHODS: A cohort study was performed using the UK Clinical Practice Research Datalink (1988-2012). A cohort of antidiabetic drug users was matched at baseline to a non-diabetic cohort, by age, sex, and practice...
April 26, 2018: Cancer Epidemiology
Alice S Forster, Cristina Renzi, Georgios Lyratzopoulos
No abstract text is available yet for this article.
April 24, 2018: Cancer Epidemiology
Laura Botta, Riccardo Capocaccia, Annalisa Trama, Christian Herrmann, Diego Salmerón, Roberta De Angelis, Sandra Mallone, Ettore Bidoli, Rafael Marcos-Gragera, Dorota Dudek-Godeau, Gemma Gatta, Ramon Cleries
BACKGROUND: The RARECAREnet project has updated the estimates of the burden of the 198 rare cancers in each European country. Suspecting that scant data could affect the reliability of statistical analysis, we employed a Bayesian approach to estimate the incidence of these cancers. METHODS: We analyzed about 2,000,000 rare cancers diagnosed in 2000-2007 provided by 83 population-based cancer registries from 27 European countries. We considered European incidence rates (IRs), calculated over all the data available in RARECAREnet, as a valid a priori to merge with country-specific observed data...
April 20, 2018: Cancer Epidemiology
Erin C Peckham-Gregory, Roberto E Montenegro, David A Stevenson, David H Viskochil, Michael E Scheurer, Philip J Lupo, Joshua D Schiffman
BACKGROUND: Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States. METHODS: OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino")...
April 20, 2018: Cancer Epidemiology
Shama Virani, Elizabeth C Wetzel, Suphawat Laohawiriyakamol, Pleumjit Boonyaphiphat, Alan Geater, Celina G Kleer, Judy Pang, Katie M Rentschler, Justin A Colacino, Carlos F Mendes de Leon, Laura S Rozek, Hutcha Sriplung
BACKGROUND: Breast cancer has the highest incidence in women of all cancers and its burden is expected to continue to increase worldwide, especially in middle-income countries such as Thailand. The southern region of Thailand is unique in that it is comprised of 30% Muslims, whereas the rest of Thailand is 95% Buddhist. Breast cancer incidence and survival differ between these religious groups, but the association between clinical subtype of breast cancer and survival has not yet been assessed...
April 20, 2018: Cancer Epidemiology
Grigorios I Leontiadis, Alexander C Ford, Colin W Howden
No abstract text is available yet for this article.
April 17, 2018: Cancer Epidemiology
Dimitrios Doganis, Paraskevi Panagopoulou, Athanasios Tragiannidis, Marios K Georgakis, Maria Moschovi, Sofia Polychronopoulou, Efthimia Rigatou, Eugenia Papakonstantinou, Eftichia Stiakaki, Helen Dana, Evdoxia Bouka, Luis Antunes, Joana Bastos, Daniela Coza, Anna Demetriou, Domenic Agius, Sultan Eser, Anton Ryzhov, Mario Sekerija, Maciej Trojanowski, Tina Zagar, Anna Zborovskaya, Snezana Zivkovic Perisic, Kalliopi Stefanaki, Nick Dessypris, Eleni Th Petridou
BACKGROUND: Despite advances in the management of nephroblastoma (Wilms' tumor, WT), the etiology of the tumor remains obscure. We aimed to compare nephroblastoma incidence rates and time trends among children (0-14 years) in 12 Southern and Eastern European (SEE) countries and the Surveillance, Epidemiology, and End Results Program (SEER), USA, in relation to the human development index (HDI). METHODS: In total 1776 WT cases were recorded in 13 SEE collaborating registries (circa 1990-2016), whereas data on 2260 cases (1990-2012) were extracted from the SEER database...
April 11, 2018: Cancer Epidemiology
Geoffrey C Kabat, Thomas E Rohan
BACKGROUND: Little is known about risk factors for adult glioma. Adiposity has received some attention as a possible risk factor. METHODS: We examined the association of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR), measured at enrollment, as well as self-reported weight earlier in life, with risk of glioma in a large cohort of postmenopausal women. Over 18 years of follow-up, 217 glioma cases were ascertained, including 164 glioblastomas...
April 11, 2018: Cancer Epidemiology
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