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Cancer Epidemiology

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https://www.readbyqxmd.com/read/28822325/are-there-regional-tendencies-toward-controversial-screening-practices-a-study-of-prostate-and-breast-cancer-screening-in-a-medicare-population
#1
Eric Raffin, Tracy Onega, Julie Bynum, Andrea Austin, Donald Carmichael, Kristen Bronner, Philip Goodney, Elias S Hyams
INTRODUCTION: Prostate and breast cancer screening in older patients continue to be controversial. Balancing the desire for early detection with avoidance of over-diagnosis has led to competing and contradictory guidelines for both practices. Despite similarities, it is not known how these screening practices are related at the regional level. In this study, we examined how screening PSA and mammography are related within healthcare regions, and, to better understand what may be driving these practices, whether they are associated with local intensity of care...
August 16, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28818742/citrus-cervical-cancer-screening-trial-by-randomization-of-hpv-testing-intervention-for-upcoming-screening-design-methods-and-baseline-data-of-18-471-women
#2
Tohru Morisada, Katsuhiro Teramoto, Hirokuni Takano, Ikuko Sakamoto, Hiroshi Nishio, Takashi Iwata, Akihiko Hashi, Ryohei Katoh, Aikou Okamoto, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
BACKGROUND: To assess the efficacy of screening with concurrent liquid-based cytology and human papillomavirus (HPV) testing for primary cervical cancer screening, we initiated a randomized trial entitled CervIcal cancer screening Trial by Randomization of HPV testing intervention for Upcoming Screening (CITRUS). METHODS: Between June 2013 and March 2015, women aged 30-64 years of age who participated in a regular cervical cancer screening program (every 2 years) were invited to enrollment of our study...
August 14, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28810175/time-trends-for-prostate-cancer-mortality-in-brazil-and-its-geographic-regions-an-age-period-cohort-analysis
#3
Sonia Faria Mendes Braga, Mirian Carvalho de Souza, Mariangela Leal Cherchiglia
BACKGROUND: In the 1980s, an increase in mortality rates for prostate cancer was observed in North America and developed European countries. In the 1990s, however, mortality rates decreased for these countries, an outcome related to early detection of the disease. Conversely, an upward trend in mortality rates was observed in Brazil. This study describe the trends in mortality for prostate cancer in Brazil and geographic regions (North, Northeast, South, Southeast, and Central-West) between 1980 until 2014 and analyze the influence of age, period, and cohort effects on mortality rates...
August 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28807680/patient-characteristics-and-cancer-prevalence-in-the-danish-cancer-patient-pathway-for-patients-with-serious-non-specific-symptoms-and-signs-of-cancer-a-nationwide-population-based-cohort-study
#4
E Moseholm, B Ø Lindhardt
BACKGROUND: A new cancer patient pathway for patients presenting with non-specific signs and symptoms (NSSC-CPP) was implemented nationally in Denmark in 2012. This study aims to describe, on a national level, the characteristics of patients referred to the Danish NSSC-CPP, and to estimate the prevalence and distribution of cancers and other diagnosis in this population. METHODS: A population-based cohort study using the Danish national registries, including all patients who completed a diagnostic course through the NSSC-CPP between 2012 and 2015...
August 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28803070/sex-disparities-in-cancer-incidence-in-jiashan-county-china-1995-2014
#5
Xiyi Jiang, Shaofang Cai, Yunqing Hu, Ding Ye, Qilong Li, Kun Chen, Mingjuan Jin
PURPOSE: To describe the sex-specific incidence rates and the male-to-female incidence-rate ratios (IRRs) of different cancer types, and to explore the corresponding sex disparities in an area of Eastern China. METHODS: We used data from the Cancer Registry in Jiashan County, and calculated the sex-specific age-standardized (2010 China standard population) incidence rates and the male-to-female IRRs for different cancer types during the period 1995-2014. RESULTS: The age-standardized incidence rates of all cancers for the whole period 1995-2014 were 151...
August 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28797893/genetic-association-of-telomere-length-with-hepatocellular-carcinoma-risk-a-mendelian-randomization-analysis
#6
Yue Cheng, Chengxiao Yu, Mingtao Huang, Fangzhi Du, Ci Song, Zijian Ma, Xiangjun Zhai, Yuan Yang, Jibin Liu, Jin-Xin Bei, Weihua Jia, Guangfu Jin, Shengping Li, Weiping Zhou, Jianjun Liu, Juncheng Dai, Zhibin Hu
BACKGROUND: Observational studies show an association between telomere length and Hepatocellular carcinoma (HCC) risk, but the relationship is controversial. Particularly, it remains unclear whether the association is due to confounding or biases inherent in conventional epidemiological studies. Here, we applied Mendelian randomization approach to evaluate whether telomere length is causally associated with HCC risk. METHODS: Individual-level data were from HBV-related HCC Genome-wide association studies (1,538 HBV positive HCC patients and 1,465 HBV positive controls)...
August 7, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28783501/high-risk-family-colorectal-cancer-screening-service-in-ireland-critical-review-of-clinical-outcomes
#7
Margaret Walshe, Robert Moran, Marie Boyle, Ion Cretu, Zita Galvin, Victoria Swan, Jason Trikovic, Michael P Farrell, Sinéad Foy, Loretta O'Brien, Jan Leyden, Niall Mulligan, Helen Fenlon, David J Gallagher, Padraic MacMathúna
BACKGROUND: We present the 15-year experience of a family colorectal cancer screening service in Ireland with emphasis on real life experience and outcomes. METHODS: Questionnaires were used to assess family cancer history and assign patients to risk categories; 'Moderate Risk', HNPCC, (suspected) genetic syndrome (non-HNPCC), 'Low Risk'. Screening was by full colonoscopy. We report neoplastic yield, examining effect of risk category, age, gender, and index colonoscopy findings...
August 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28781173/clinical-characteristics-and-risk-of-serious-disease-in-patients-referred-to-a-diagnostic-centre-a-cohort-study
#8
Esben Næser, Ulrich Fredberg, Henrik Møller, Peter Vedsted
BACKGROUND: Little is known about the clinical characteristics of patients referred to a diagnostic centre through the Danish urgent referral pathway for non-specific serious symptoms. We aimed at estimating the distribution of serious disease and the diagnostic value of clinical characteristics for the diagnosis of cancer and serious non-malignant disease in these patients. METHOD: A cohort study of 938 patients referred by their GP to the diagnostic centre at Silkeborg Regional Hospital...
August 3, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28780478/trends-in-brain-cancer-mortality-among-u-s-gulf-war-veterans-21-year-follow-up
#9
Shannon K Barth, Erin K Dursa, Robert M Bossarte, Aaron I Schneiderman
OBJECTIVE: Previous mortality studies of U.S. Gulf War veterans through 2000 and 2004 have shown an increased risk of brain cancer mortality among some deployed individuals. When veterans possibly exposed to environmental contaminants associated with demolition of the Khamisiyah Ammunition Storage Facility at Khamisiyah, Iraq, have been compared to contemporaneously deployed unexposed veterans, the results have suggested increased risk for mortality from brain cancer among the exposed...
August 3, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28763723/validity-of-self-reported-cancer-history-in-the-health-examinees-hexa-study-a-comparison-of-self-report-and-cancer-registry-records
#10
Sooyoung Cho, Aesun Shin, Daesub Song, Jae Kyung Park, Yeonjung Kim, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee
PURPOSE: To assess the validity of the cohort study participants' self-reported cancer history via data linkage to a cancer registry database. METHODS: We included 143,965 participants from the Health Examinees (HEXA) study recruited between 2004 and 2013 who gave informed consent for record linkage to the Korean Central Cancer Registry (KCCR). The sensitivity and the positive predictive value of self-reported histories of cancer were calculated and 95% confidence intervals were estimated...
July 29, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28756308/self-reported-shift-work-recall-bias-and-belief-about-disease-causation-in-a-case-control-study-of-breast-cancer
#11
Natalia Lizama, Jane Heyworth, Allyson Thomson, Terry Slevin, Lin Fritschi
BACKGROUND: Recall bias is a potential source of misclassification in case-control studies. Studies have shown that the association between exposure and disease can differ according to participants' beliefs or knowledge about the effect of that exposure on disease. We investigated the association between belief about breast cancer causation and self-reported shift work exposure in a case-control study. METHODS: Women completed a questionnaire asking whether they believed that shift work caused cancer either before or after reporting their history of shift work...
July 27, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28738268/descriptive-epidemiology-of-primary-malignant-and-non-malignant-central-nervous-tumors-in-spain-results-from-the-girona-cancer-registry-1994-2013
#12
Rafael Fuentes-Raspall, Marta Solans, Aina Roca-Barceló, Loreto Vilardell, Montse Puigdemont, Sonia Del Barco, Raquel Comas, Adelaida García-Velasco, Aurora Astudillo, Mª Carme Carmona-Garcia, Rafael Marcos-Gragera
BACKGROUND: Systematic registration of non-malignant central nervous system (CNS) tumors is a rare practice among European cancer registries. Thus, the real burden of all CNS tumors across Europe is underestimated. The Girona Cancer Registry provides here the first data on CNS tumor incidence and survival trends in Spain for all histological types, including malignant and non-malignant tumors. METHODS: Data on all incident cases of primary CNS tumors notified to the Girona population-based cancer registry from 1994 to 2013 (n=2,131) were reviewed...
July 21, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28734233/risk-of-hospitalization-among-survivors-of-childhood-and-adolescent-acute-lymphoblastic-leukemia-compared-to-siblings-and-a-general-population-sample
#13
Judy Y Ou, Rochelle R Smits-Seemann, Sapna Kaul, Mark N Fluchel, Carol Sweeney, Anne C Kirchhoff
BACKGROUND: Acute Lymphoblastic Leukemia (ALL) has a high survival rate, but cancer-related late effects in the early post-treatment years need documentation. Hospitalizations are an indicator of the burden of late effects. We identify rates and risk factors for hospitalization from five to ten years after diagnosis for childhood and adolescent ALL survivors compared to siblings and a matched population sample. METHODS: 176 ALL survivors were diagnosed at ≤22 years between 1998 and 2008 and treated at an Intermountain Healthcare facility...
July 19, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28732327/prediagnostic-serum-calcium-and-albumin-and-ovarian-cancer-a-nested-case-control-study-in-the-norwegian-janus-serum-bank-cohort
#14
Gary G Schwartz, Steinar Tretli, Linda Vos, Trude E Robsahm
BACKGROUND: Women with higher serum calcium may be more likely to be diagnosed and die of ovarian cancer. We evaluated that finding in a large, prospective cohort. METHODS: We conducted a nested case-control study using a population-based biobank from Norway. We compared 202 ovarian cancer cases and 202 controls, matched for age, date at blood draw, and county of residence, with respect to serum calcium and albumin, adjusted for anthropometric variables. We evaluated risks using the entire follow-up period as well as 2-15 years and 16-25 years ("early" and "late", respectively)...
July 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28711854/exploration-of-the-possible-effect-on-survival-of-lead-time-associated-with-implementation-of-cancer-patient-pathways-among-symptomatic-first-time-cancer-patients-in-denmark
#15
Henry Jensen, Peter Vedsted
BACKGROUND: Implementation of standardised cancer patient pathways (CPPs) has provided faster diagnosis of cancer. Cancer survival has improved during the same time period. Concern has been raised that the faster diagnosis may have introduced lead-time bias by elongating the period from diagnosis to death. AIM: We aimed to analyse the possible effect of lead time on survival due to expedited cancer diagnosis after the implementation of national CPPs among incident cancer patients diagnosed through Danish primary care...
July 13, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28710943/survival-after-recurrence-of-stage-i-iii-breast-colorectal-or-lung-cancer
#16
Michael J Hassett, Hajime Uno, Angel M Cronin, Nikki M Carroll, Mark C Hornbrook, Paul Fishman, Debra P Ritzwoller
BACKGROUND: The experiences of patients with recurrent cancer are assumed to reflect those of patients with de novo stage IV disease; yet, little is truly known because most registries lack recurrence status. Using two databases with excellent recurrence and death information, we examined determinants of survival duration after recurrence of breast (BC), colorectal (CRC), and lung cancers (LC). METHODS: Recurrence status was abstracted from the medical records of patients who participated in the Cancer Care Outcomes Research and Surveillance study and who received care at two Cancer Research Network sites-the Colorado and Northwest regions of Kaiser Permanente...
July 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28709062/cancer-incidence-in-the-agrican-cohort-study-2005-2011
#17
Clémentine Lemarchand, Séverine Tual, Noémie Levêque-Morlais, Stéphanie Perrier, Aurélien Belot, Michel Velten, Anne-Valérie Guizard, Elisabeth Marcotullio, Alain Monnereau, Bénédicte Clin, Isabelle Baldi, Pierre Lebailly
BACKGROUND: Numerous studies have been conducted among farmers, but very few of them have involved large prospective cohorts, and few have included a significant proportion of women and farm workers. Our aim was to compare cancer incidence in the cohort (overall, by sex, and by work on farm, occupational status and pesticide use) within the general population. METHODS: More than 180,000 participants in the AGRICAN cohort were matched to cancer registries to identify cancer cases diagnosed from enrolment (2005-2007) to 31st December 2011...
July 11, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28704717/implementing-community-based-cervical-cancer-screening-programs-using-visual-inspection-with-acetic-acid-in-india-a-systematic-review
#18
REVIEW
Prajakta Adsul, Nitin Manjunath, Vijaya Srinivas, Anjali Arun, Purnima Madhivanan
The objective of this review was to systematically appraise the existing published literature about community-based cervical cancer screening programs that have used visual inspection methods using acetic acid (VIA) in India. All peer reviewed journal articles till December 2015 were searched per PRISMA guidelines. Articles reporting results from cervical cancer screening programs in community-based settings, conducted in India, and using VIA were included in this review. The search resulted in 20 articles to be included in the review with a total of 313,553 women at 12 unique urban and rural sites across India...
July 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28697417/tumor-characteristics-and-family-history-in-relation-to-mammographic-density-and-breast-cancer-the-french-e3n-cohort
#19
Gertraud Maskarinec, Laureen Dartois, Suzette Delaloge, John Hopper, Françoise Clavel-Chapelon, Laura Baglietto
BACKGROUND: Mammographic density is a known heritable risk factor for breast cancer, but reports how tumor characteristics and family history may modify this association are inconsistent. METHODS: Dense and total breast areas were assessed using Cumulus™ from pre-diagnostic mammograms for 820 invasive breast cancer cases and 820 matched controls nested within the French E3N cohort study. To allow comparisons across models, percent mammographic density (PMD) was standardized to the distribution of the controls...
July 8, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28651179/sedentary-work-and-the-risks-of-colon-and-rectal-cancer-by-anatomical-sub-site-in-the-canadian-census-health-and-environment-cohort-canchec
#20
Manisha Pahwa, M Anne Harris, Jill MacLeod, Michael Tjepkema, Paul A Peters, Paul A Demers
BACKGROUND: Sedentary behaviour is a potential risk factor for colorectal cancer. We examined the association between sedentary work, based on body position, and colorectal cancer risk in Canadians. METHODS: A working body position category (a. sitting; b. standing and walking; c. sitting, standing, and walking; d. other) was assigned to occupations reported by 1991 Canadian Census respondents based on national occupational counselling guidelines. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for cancers of the colon (overall, proximal, and distal) and rectum in men and women newly diagnosed from 1992 to 2010...
June 23, 2017: Cancer Epidemiology
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