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Aging

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https://www.readbyqxmd.com/read/29769432/deacetylation-of-metabolic-enzymes-by-sirt2-modulates-pyruvate-homeostasis-to-extend-insect-lifespan
#1
Tao Wang, Shao-Lei Geng, Yu-Min Guan, Wei-Hua Xu
Diapause in insects is akin to dauer in Caenorhabditis elegans and hibernation in vertebrates. Diapause causes a profound extension of lifespan by low metabolic activity. However, the detailed regulatory mechanisms for low metabolic activity remain unknown. Here, we showed that low pyruvate levels are present in the brains of diapause-destined pupae of the cotton bollworm Helicoverpa armigera , and three enzymes pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), and phosphoglycerate mutase (PGAM) are closely correlated with pyruvate homeostasis...
May 16, 2018: Aging
https://www.readbyqxmd.com/read/29769431/integrative-analysis-of-gut-microbiota-composition-host-colonic-gene-expression-and-intraluminal-metabolites-in-aging-c57bl-6j-mice
#2
Benthe van der Lugt, Fenni Rusli, Carolien Lute, Andreas Lamprakis, Ethel Salazar, Mark V Boekschoten, Guido J Hooiveld, Michael Müller, Jacques Vervoort, Sander Kersten, Clara Belzer, Dieuwertje E G Kok, Wilma T Steegenga
The aging process is associated with diminished colonic health. In this study, we applied an integrative approach to reveal potential interactions between determinants of colonic health in aging C57BL/6J mice. Analysis of gut microbiota composition revealed an enrichment of various potential pathobionts, including Desulfovibrio spp . , and a decline of the health-promoting Akkermansia spp . and Lactobacillus spp. during aging. Intraluminal concentrations of various metabolites varied between ages and we found evidence for an increased gut permeability at higher age...
May 16, 2018: Aging
https://www.readbyqxmd.com/read/29754148/age-prediction-of-children-and-adolescents-aged-6-17-years-an-epigenome-wide-analysis-of-dna-methylation
#3
Chunxiao Li, Wenjing Gao, Ying Gao, Canqing Yu, Jun Lv, Ruoran Lv, Jiali Duan, Ying Sun, Xianghui Guo, Weihua Cao, Liming Li
The DNA methylation age, a good reflection of human aging process, has been used to predict chronological age of adults and newborns. However, the prediction model for children and adolescents was absent. In this study, we aimed to generate a prediction model of chronological age for children and adolescents aged 6-17 years by using age-specific DNA methylation patterns from 180 Chinese twin individuals. We identified 6,350 age-related CpGs from the epigenome-wide association analysis (N=179). 116 known age-related sites in children were confirmed...
May 12, 2018: Aging
https://www.readbyqxmd.com/read/29754145/it-is-necessary-to-establish-an-international-agency-for-research-on-aging
#4
Vladimir N Anisimov, Alexandre V Sidorenko
The global aging of human population is one of the main challenges and opportunities of the 21st century. Establishing an International Agency for Research on Aging as an entity affiliated to one of the intergovernmental institutions, such as the World Health Organization, can be crucial for promoting international collaboration in gerontology, in particular in a search of effective and safe geroprotectors for humans.
May 12, 2018: Aging
https://www.readbyqxmd.com/read/29754146/transcriptional-e2f1-2-5-8-as-potential-targets-and-transcriptional-e2f3-6-7-as-new-biomarkers-for-the-prognosis-of-human-lung-carcinoma
#5
Cheng-Cao Sun, Qun Zhou, Wei Hu, Shu-Jun Li, Feng Zhang, Zhen-Long Chen, Guang Li, Zhuo-Yue Bi, Yong-Yi Bi, Feng-Yun Gong, Tao Bo, Zhan-Peng Yuan, Wei-Dong Hu, Bo-Tao Zhan, Qian Zhang, Qi-Zhu Tang, De-Jia Li
E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. In the current study, we examined the transcriptional and survival data of E2Fs in patients with LC from ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases...
May 11, 2018: Aging
https://www.readbyqxmd.com/read/29754147/non-senescent-hydra-tolerates-severe-disturbances-in-the-nuclear-lamina
#6
Alexander Klimovich, Arvid Rehm, Jörg Wittlieb, Eva-Maria Herbst, Ricardo Benavente, Thomas C G Bosch
The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra . We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization...
May 10, 2018: Aging
https://www.readbyqxmd.com/read/29746255/a-novel-functional-polymorphism-of-gfap-decrease-glioblastoma-susceptibility-through-inhibiting-the-binding-of-mir-139
#7
Jie Wang, Ming-Lei Wang, Chang-Hui Wang, Shu-Yan Sun, Han-Bing Zhang, Yang-Yang Jiang, Qi-Wu Xu, Ying Wang, Shi-Xin Gu
Glioblastoma (GBM) is the most commonly diagnosed solid tumor outside the central nervous system. However, genetic factors underlying GBM remain largely unclear. Previous studies indicated that Glial fibrillary acidic protein ( GFAP ) might play an important role in the aggressiveness of GBM and also contributed to its poor overall survival. The present study aims to test (1) the associations between GFAP single nucleotide polymorphisms (SNPs) and GBM cells chemoresistance and metastasis, and (2) the molecular mechanism accounting for their effects...
May 10, 2018: Aging
https://www.readbyqxmd.com/read/29729650/class-iia-hdacs-in-myelination
#8
Sergio Velasco-Aviles, Jose A Gomez-Sanchez, Hugo Cabedo
No abstract text is available yet for this article.
May 5, 2018: Aging
https://www.readbyqxmd.com/read/29723157/testosterone-and-dihydrotestosterone-reduce-platelet-activation-and-reactivity-in-older-men-and-women
#9
Kamil Karolczak, Lucyna Konieczna, Tomasz Kostka, Piotr J Witas, Bartlomiej Soltysik, Tomasz Baczek, Cezary Watala
The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no ex vivo studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets - one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation (surface membrane expression of GPII/IIIa complex and P-selectin) and platelet reactivity in response to arachidonate, collagen or ADP, monitored with whole blood aggregometry and flow cytometry...
May 2, 2018: Aging
https://www.readbyqxmd.com/read/29723158/circrnas-in-the-tree-shrew-tupaia-belangeri-brain-during-postnatal-development-and-aging
#10
CaiXia Lu, XiaoMei Sun, Na Li, WenGuang Wang, DeXuan Kuang, PinFen Tong, YuanYuan Han, JieJie Dai
Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression and function of circRNAs in the tree shrew brain. In this study, we used RNA-seq to identify 35,007 circRNAs in hippocampus and cerebellum samples from infant (aged 47-52 days), young (aged 15-18 months), and old (aged 78-86 months) tree shrews. We observed no significant changes in the total circRNA expression profiles in different brain regions over time...
April 30, 2018: Aging
https://www.readbyqxmd.com/read/29706613/accessory-signals-in-protein-translocation
#11
Katja G Hansen, Felix Boos, Johannes M Herrmann
No abstract text is available yet for this article.
April 28, 2018: Aging
https://www.readbyqxmd.com/read/29706612/phospholipid-transfer-by-ermes-components
#12
Toshiya Endo, Yasushi Tamura, Shin Kawano
No abstract text is available yet for this article.
April 28, 2018: Aging
https://www.readbyqxmd.com/read/29706611/decreased-nad-in-dopaminergic-neurons
#13
Samantha L Sison, Allison D Ebert
No abstract text is available yet for this article.
April 28, 2018: Aging
https://www.readbyqxmd.com/read/29706610/age-related-neuropathies-and-tubulin-acetylation
#14
Jaime Fernández-Barrera, Isabel Correas, Miguel A Alonso
No abstract text is available yet for this article.
April 28, 2018: Aging
https://www.readbyqxmd.com/read/29706609/-ran-ranbp2-polymorphisms-and-neuroblastoma-risk-in-chinese-children-a-three-center-case-control-study
#15
Juxiang Wang, Zhenjian Zhuo, Min Chen, Jinhong Zhu, Jie Zhao, Jiao Zhang, Shanshan Chen, Jing He, Haixia Zhou
The genetic etiology of sporadic neuroblastoma remains largely obscure. RAN and RANBP2 genes encode Ras-related nuclear protein and Ran-binding protein 2, respectively. These two proteins form Ran-RanBP2 complex that regulate various cellular activities including nuclear transport. Aberrant functions of the two proteins are implicated in carcinogenesis. Given the unknown role of RAN/RANBP2 single nucleotide polymorphisms (SNPs) in neuroblastoma risk, we performed a multi-center case-control study in Chinese children to assess the association of the RAN/RANBP2 SNPs with neuroblastoma risk...
April 28, 2018: Aging
https://www.readbyqxmd.com/read/29706608/age-associated-bimodal-transcriptional-drift-reduces-intergenic-disparities-in-transcription
#16
Byungkuk Min, Myungsun Park, Kyuheum Jeon, Jung Sun Park, Hyemyung Seo, Sangkyun Jeong, Yong-Kook Kang
This study addressed the question of how well the quantitative transcriptome structure established in early life is maintained and how consistently it appears with increasing age, and if there is age-associated alteration of gene expression (A3 GE), how much influence the Huntington's disease (HD) genotype exerts on it. We examined 285 exonic sequences of 175 genes using targeted PCR sequencing in skeletal muscle, brain, and splenic CD4+ T cells of wild-type and HD mice. In contrast to the muscle and brain, T cells exhibited large A3 GE, suggesting a strong contribution to functional decline of the organism...
April 27, 2018: Aging
https://www.readbyqxmd.com/read/29706607/identifying-circrna-associated-cerna-networks-in-the-hippocampus-of-a%C3%AE-1-42-induced-alzheimer-s-disease-like-rats-using-microarray-analysis
#17
Zhe Wang, Panpan Xu, Biyue Chen, Zheyu Zhang, Chunhu Zhang, Qiong Zhan, Siqi Huang, Zi-An Xia, Weijun Peng
Alzheimer's disease (AD) is the most common form of dementia worldwide. Accumulating evidence indicates that non-coding RNAs are strongly implicated in AD-associated pathophysiology. However, the role of these ncRNAs remains largely unknown. In the present study, we used microarray analysis technology to characterize the expression patterns of circular RNAs (circRNAs), microRNAs (miRNAs), and mRNAs in hippocampal tissue from Aβ1-42 -induced AD model rats, to integrate interaction data and thus provide novel insights into the mechanisms underlying AD...
April 27, 2018: Aging
https://www.readbyqxmd.com/read/29695643/swiprosin-1-efhd2-another-piece-in-the-puzzle-of-tauopathy
#18
Martin Regensburger, Dirk Mielenz, Beate Winner
No abstract text is available yet for this article.
April 25, 2018: Aging
https://www.readbyqxmd.com/read/29695642/novel-role-of-autophagy-associated-pik3c3-gene-in-gonadal-white-adipose-tissue-browning-in-aged-c57-bl6-male-mice
#19
Amiya Kumar Ghosh, Theresa Mau, Martin O'Brien, Raymond Yung
Adipose tissue dysfunction is associated with inflammation, metabolic syndrome and other diseases in aging. Recent work has demonstrated that compromised autophagy activity in aging adipose tissue promotes ER stress responses, contributing to adipose tissue and systemic inflammation in aging. Phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3) is an 887 amino acid lipid kinase that regulates intracellular membrane trafficking and autophagy activity. To address the mechanistic link between autophagy and ER stress response in aging adipose tissue, we generated a line of adipose tissue-specific Pik3c3 knock out (~mutant mice) with the Fabp4 (Fatty acid binding protein 4) promoter driven Cre recombinase system...
April 25, 2018: Aging
https://www.readbyqxmd.com/read/29695641/oxidative-stress-mediated-senescence-in-mesenchymal-progenitor-cells-causes-the-loss-of-their-fibro-adipogenic-potential-and-abrogates-myoblast-fusion
#20
Hidetoshi Sugihara, Naomi Teramoto, Keitaro Yamanouchi, Takashi Matsuwaki, Masugi Nishihara
Sarcopenia is the age-related loss of skeletal muscle mass and function. Skeletal muscle comprises diverse progenitor cells, including mesenchymal progenitor cells (MPCs), which normally support myogenic cell function but cause a decline in skeletal muscle function after differentiating into fibrous/adipose tissue. Cellular senescence is a form of persistent cell cycle arrest caused by cellular stress, including oxidative stress, and is accompanied by the acquisition of senescence-associated secretory phenotype (SASP)...
April 25, 2018: Aging
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