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Itamar Lerner, Ravi Sojitra, Mark Gluck
No abstract text is available yet for this article.
November 12, 2018: Aging
Elena Chiappini, Martina Bianconi, Annalisa Dalzini, Maria Raffaella Petrara, Luisa Galli, Carlo Giaquinto, Anita De Rossi
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed published in English language in 2004-2017, using appropriate key words, including "aging", "children", "HIV", "AIDS", "immunosenescence", "pathogenesis", "clinical conditions"...
November 11, 2018: Aging
Xu Gao, Elena Colicino, Jincheng Shen, Allan C Just, Jamaji C Nwanaji-Enwerem, Brent Coull, Xihong Lin, Pantel Vokonas, Yinan Zheng, Lifang Hou, Joel Schwartz, Andrea A Baccarelli
The discrepancy of DNA methylation age (DNAmAge) with chronological age (termed as age acceleration, AA) has been identified to be associated with many aging-related health outcomes including hypertension. Since taking antihypertensive medication (AHM) could prevent aging-related diseases caused by hypertension, we hypothesized that using AHM could also reduce the AA. We examined this hypothesis among 546 males aged 55-85 years by exploring the associations of AHM use with AA and its change rate (ΔAA ) in two visits with a median follow-up of 3...
November 10, 2018: Aging
Eugene Bobrov, Anastasia Georgievskaya, Konstantin Kiselev, Artem Sevastopolsky, Alex Zhavoronkov, Sergey Gurov, Konstantin Rudakov, Maria Del Pilar Bonilla Tobar, Sören Jaspers, Sven Clemann
Aging biomarkers are the qualitative and quantitative indicators of the aging processes of the human body. Estimation of biological age is important for assessing the physiological state of an organism. The advent of machine learning lead to the development of the many age predictors commonly referred to as the "aging clocks" varying in biological relevance, ease of use, cost, actionability, interpretability, and applications. Here we present and investigate a novel non-invasive class of visual photographic biomarkers of aging...
November 9, 2018: Aging
Ana M Valdes, Cristina Menni
No abstract text is available yet for this article.
November 9, 2018: Aging
Feilun Cui, Huaming Tang, Jian Tan, Jianpeng Hu
Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain of kinetochores. We recently showed that SPC25 is required for prostate cancer (PrC) cell proliferation and cell cycle progression, and here we investigated whether SPC25 may be a Cancer stem cell (CSC) marker in PrC. We found that the levels of SPC25 were higher in PrC samples than paired normal prostate tissue. The overall survival of PrC patients with high SPC25 was poorer than those with low SPC25...
November 8, 2018: Aging
Mikhail Shaposhnikov, Ekaterina Proshkina, Lyubov Koval, Nadezhda Zemskaya, Alex Zhavoronkov, Alexey Moskalev
Recent experimental studies highlighted the role of hydrogen sulfide (H2 S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2 S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila . Overexpression of CSE did not affect a lifespan and decrease (mitochondrial form of CSE ) or increase (cytoplasmic form of CSE ) age dynamics of locomotor activity, while overexpression of CBS increase median (by 12...
November 8, 2018: Aging
Zhengui Zhou, Ruoyu Huang, Ruichao Chai, Xiaohong Zhou, Zhiping Hu, Wenbiao Wang, Baoguo Chen, Lintao Deng, Yuqing Liu, Fan Wu
Now, numerous exciting findings have been yielded in the field of energy metabolism within glioma cells. In addition to aerobic glycolysis, multiple catabolic pathways are employed for energy production. However, the prognostic significance of energy metabolism in glioma remains obscure. Here, we explored the relationship between energy metabolism gene profile and outcome of diffuse glioma patients using The Cancer Genome Altas (TCGA) and Chinese Glioma Genome Altas (CGGA) datasets. Based on the gene expression profile, consensus clustering identified two robust clusters of glioma patients with distinguished prognostic and molecular features...
November 8, 2018: Aging
Olalla Pancorbo, David Rodriguez-Luna
No abstract text is available yet for this article.
November 7, 2018: Aging
Hansjörg Schwertz, Matthew T Rondina
No abstract text is available yet for this article.
November 6, 2018: Aging
Jose J Lopez, Isaac Jardin, Juan A Rosado
No abstract text is available yet for this article.
November 6, 2018: Aging
Yabin Gong, Zhilong Zhang, Zhanglin Chang, Hao Zhou, Ruqian Zhao, Bin He
The rapid and efficient clearance of apoptotic germ cells (GCs) by Sertoli cells (SCs) is important for spermatogenesis. High mitochondrial activity in phagocytes is critical for continued clearance of apoptotic cells. However, the underlying molecular mechanism is poorly understood. Glycogen synthase kinase-3α (GSK3α) is a protein kinase that participates in the regulation of mitochondrial activity. Immunohistochemistry evidenced the predominant presence of the Ser21 phosphorylation GSK3α (inactivation) signal in SCs...
November 6, 2018: Aging
Isabella Zironi, Entelë Gavoçi, Giovanna Lattanzi, Angela Virelli, Fabrizio Amorini, Daniel Remondini, Gastone Castellani
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder wherein symptoms resembling aspects of aging are manifested at a very early age. It is a genetic condition that occurs due to a de novo mutation in the LMNA gene encoding for the nuclear structural protein lamin A. The lamin family of proteins are thought to be involved in nuclear stability, chromatin structure and gene expression and this leads to heavy effects on the regulation and functionality of the cell machinery. The functional role of the large-conductance calcium-activated potassium channels (BKCa ) is still unclear, but has been recently described a strong relationship with their membrane expression, progerin nuclear levels and the ageing process...
November 6, 2018: Aging
Jing Fang, Fengyuan Wang, Hetao Song, Zhengyi Wang, Zhicai Zuo, Hengmin Cui, Yiping Jia, Junliang Deng, Shumin Yu, Yanchun Hu, Liuhong Shen, Xiaoping Ma, Zhihua Ren, Liping Gou
To investigate the different effects of acute pulmonary infection induced by Escherichia coli ( E. coli ) on lipid metabolism between diet-induced obesity (DIO, fed with high-fat diet) mice and lean mice. A total of 180 ICR mice were selected to be challenged intranasally with phosphate-buffered saline or 109 CFUs/mL of E. coli , and the body character indexes, biochemical indexes and expressions of genes and proteins involved in lipid metabolism were examined pre- and post-infection. Results revealed that, before infection, DIO mice had significantly higher body weight, adipose and liver indexes, free fatty acid and triglyceride contents than lean mice...
November 6, 2018: Aging
Jan Laczó, Martina Parizkova, Scott D Moffat
No abstract text is available yet for this article.
November 4, 2018: Aging
Xian-Tao Wang, Xiao-Dan Wu, Yuan-Xi Lu, Yu-Han Sun, Han-Hua Zhu, Jia-Bao Liang, Wen-Kai He, Lang Li
Coronary microembolization (CME) substantially reduces the clinical benefits of myocardial reperfusion therapy. Autophagy and apoptosis participate in the pathophysiological processes of almost all cardiovascular diseases, including CME-induced myocardial injury, but the precise underlying mechanisms remain unclear. In the present study, we observed that Egr-1 expression was substantially increased after CME modeling. Inhibition of Egr-1 expression through the targeted delivery of rAAV9-Egr-1-shRNA improved cardiac function and reduced myocardial injury...
November 4, 2018: Aging
Na Yang, Payel Sen
A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging". Importantly, interventions that clear senescent cells have achieved marked improvements in healthspan and lifespan in mice. A growing list of studies show that environmental stimuli can affect aging and longevity through conserved pathways which, in turn, modulate chromatin states...
November 3, 2018: Aging
Chen-Di Lu, Ji-Kang Ma, Zheng-Yang Luo, Qun-Xi Tai, Pu Wang, Pei-Pei Guan
Transferrin (Tf) is an important iron-binding protein postulated to play a key role in iron ion (Fe) absorption via the Tf receptor (TfR), which potentially contributes to the pathogenesis of Alzheimer's disease (AD). However, the role of Tf in AD remains unknown. Using mouse-derived neurons and APP/PS1 transgenic (Tg) mice as model systems, we firstly revealed the mechanisms of APH-1α/1β and presenilin 1 (PS1) upregulation by Fe in prostaglandin (PG) E2 - and PGD2 -dependent mechanisms. Specifically, Fe stimulated the expression of mPGES-1 and the production of PGE2 and PGD2 via the Tf and TfR system...
November 1, 2018: Aging
Sofia Chatzidou, Georgios Georgiopoulos, Christos Kontogiannis
No abstract text is available yet for this article.
October 27, 2018: Aging
Allison B Herman, Michael V Autieri
No abstract text is available yet for this article.
October 26, 2018: Aging
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