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Aging

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https://www.readbyqxmd.com/read/28630379/the-association-between-telomere-length-and-mortality-in-bangladesh
#1
Samantha G Dean, Chenan Zhang, Jianjun Gao, Shantanu Roy, Justin Shinkle, Mekala Sabarinathan, Maria Argos, Lin Tong, Alauddin Ahmed, Md Tariqul Islam, Tariqul Islam, Muhammad Rakibuz-Zaman, Golam Sarwar, Hasan Shahriar, Mahfuzar Rahman, Md Yunus, Joseph H Graziano, Lin S Chen, Farzana Jasmine, Muhammad G Kibriya, Habibul Ahsan, Brandon L Pierce
Telomeres are tandem repeat sequences at the end of chromosomes that bind proteins to protect chromosome ends. Telomeres shorten with age, and shorter leukocyte telomere length (TL) has been associated with overall mortality in numerous studies. However, this association has not been tested in populations outside of Europe and the U.S. We assessed the association between TL and subsequent mortality using data on 744 mortality cases and 761 age-/sex-matched controls sampled from >27,000 participants from three longitudinal Bangladeshi cohorts: Health Effects of Arsenic Longitudinal Study (HEALS), HEALS Expansion (HEALS-E), and Bangladesh Vitamin E and Selenium Trial (BEST)...
June 15, 2017: Aging
https://www.readbyqxmd.com/read/28611316/effects-of-resveratrol-curcumin-berberine-and-other-nutraceuticals-on-aging-cancer-development-cancer-stem-cells-and-micrornas
#2
James A McCubrey, Kvin Lertpiriyapong, Linda S Steelman, Steve L Abrams, Li V Yang, Ramiro M Murata, Pedro L Rosalen, Aurora Scalisi, Luca M Neri, Lucio Cocco, Stefano Ratti, Alberto M Martelli, Piotr Laidler, Joanna Dulińska-Litewka, Dariusz Rakus, Agnieszka Gizak, Paolo Lombardi, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules...
June 12, 2017: Aging
https://www.readbyqxmd.com/read/28562315/aged-induced-pluripotent-stem-cell-ipscs-as-a-new-cellular-model-for-studying-premature-aging
#3
Stefania Petrini, Rossella Borghi, Valentina D'Oria, Fabrizia Restaldi, Sandra Moreno, Antonio Novelli, Enrico Bertini, Claudia Compagnucci
Nuclear integrity and mechanical stability of the nuclear envelope (NE) are conferred by the nuclear lamina, a meshwork of intermediate filaments composed of A- and B-type lamins, supporting the inner nuclear membrane and playing a pivotal role in chromatin organization and epigenetic regulation. During cell senescence, nuclear alterations also involving NE architecture are widely described. In the present study, we utilized induced pluripotent stem cells (iPSCs) upon prolonged in vitro culture as a model to study aging and investigated the organization and expression pattern of NE major constituents...
May 31, 2017: Aging
https://www.readbyqxmd.com/read/28562314/repurposing-arbs-as-treatments-for-breast-cancer
#4
Amee J George, Andrew Allen, Ashwini L Chand
No abstract text is available yet for this article.
May 31, 2017: Aging
https://www.readbyqxmd.com/read/28562321/intellectual-maturity-and-longevity-late-blooming-composers-and-writers-live-longer-than-child-prodigies
#5
Maurits P J Hafkamp, Joris P J Slaets, David van Bodegom
Life history theory links human physical and sexual development to longevity. However, there have been no studies on the association of intellectual development with longevity. This observational study investigates the relationship between the onset of intellectual maturity and lifespan through the life histories of composers and creative writers, whose intellectual development can be gauged through their compositions and writings. In these groups we model the relationship between the age at first creative work, and age at death using multilevel regression, adjusting for sex, date of birth, and nationality...
May 30, 2017: Aging
https://www.readbyqxmd.com/read/28562313/friedreich-s-ataxia-induced-pluripotent-stem-cell-derived-cardiomyocytes-display-electrophysiological-abnormalities-and-calcium-handling-deficiency
#6
Duncan E Crombie, Claire L Curl, Antonia Ja Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond Cb Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pébay
We sought to identify the impacts of Friedreich's ataxia (FRDA) on cardiomyocytes. FRDA is an autosomal recessive degenerative condition with neuronal and non-neuronal manifestations, the latter including progressive cardiomyopathy of the left ventricle, the leading cause of death in FRDA. Little is known about the cellular pathogenesis of FRDA in cardiomyocytes. Induced pluripotent stem cells (iPSCs) were derived from three FRDA individuals with characterized GAA repeats. The cells were differentiated into cardiomyocytes to assess phenotypes...
May 30, 2017: Aging
https://www.readbyqxmd.com/read/28562327/the-protein-kinase-mbk-1-contributes-to-lifespan-extension-in-daf-2-mutant-and-germline-deficient-caenorhabditis-elegans
#7
Hildegard I D Mack, Peichuan Zhang, Bryan R Fonslow, John R Yates
In Caenorhabditis elegans, reduction of insulin/IGF-1 like signaling and loss of germline stem cells both increase lifespan by activating the conserved transcription factor DAF-16 (FOXO). While the mechanisms that regulate DAF-16 nuclear localization in response to insulin/IGF-1 like signaling are well characterized, the molecular pathways that act in parallel to regulate DAF-16 transcriptional activity, and the pathways that couple DAF-16 activity to germline status, are not fully understood at present. Here, we report that inactivation of MBK-1, the C...
May 25, 2017: Aging
https://www.readbyqxmd.com/read/28582772/correction-patterns-of-brain-atrophy-associated-with-episodic-memory-and-semantic-fluency-decline-in-aging
#8
Amandine Pelletier, Charlotte Bernard, Bixente Dilharreguy, Catherine Helmer, Melanie Le Goff, Sandra Chanraud, Jean-François Dartigues, Michèle Allard, Hélène Amieva, Catheline Gwénaëlle
No abstract text is available yet for this article.
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28522793/diffuse-colonies-of-human-skin-fibroblasts-in-relation-to-cellular-senescence-and-proliferation
#9
Vadim Zorin, Alla Zorina, Nadezhda Smetanina, Pavel Kopnin, Ivan V Ozerov, Sergey Leonov, Artur Isaev, Dmitry Klokov, Andreyan N Osipov
Development of personalized skin treatment in medicine and skin care may benefit from simple and accurate evaluation of the fraction of senescent skin fibroblasts that lost their proliferative capacity. We examined whether enriched analysis of colonies formed by primary human skin fibroblasts, a simple and widely available cellular assay, could reveal correlations with the fraction of senescent cells in heterogenic cell population. We measured fractions of senescence associated β-galactosidase (SA-βgal) positive cells in either mass cultures or colonies of various morphological types (dense, mixed and diffuse) formed by skin fibroblasts from 10 human donors...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28522792/transgenic-autoinhibition-of-p21-activated-kinase-exacerbates-synaptic-impairments-and-fronto-dependent-behavioral-deficits-in-an-animal-model-of-alzheimer-s-disease
#10
Cyril Bories, Dany Arsenault, Myriam Lemire, Cyntia Tremblay, Yves De Koninck, Frédéric Calon
Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expression, particularly with symptoms related to frontal cortex dysfunction. To investigate the role of PAK combined with Aβ and tau pathologies (3xTg-AD mice) in the frontal cortex, we generated a transgenic model of AD with a deficit in PAK activity (3xTg-AD-dnPAK mice)...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28490691/the-puzzling-interplay-between-p53-and-sp1
#11
Ariella Oppenheim, Galit Lahav
No abstract text is available yet for this article.
May 9, 2017: Aging
https://www.readbyqxmd.com/read/28490690/a-decline-in-female-baboon-hypothalamo-pituitary-adrenal-axis-activity-anticipates-aging
#12
Shanshan Yang, Kenneth G Gerow, Hillary F Huber, McKenna M Considine, Cun Li, Vicki Mattern, Anthony G Comuzzie, Stephen P Ford, Peter W Nathanielsz
Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fasting morning cortisol in 24 female baboons (6-21 years, human equivalent ~18-70). We also quantified hypothalamic paraventricular nuclear (PVN) arginine vasopressin (AVP), corticotropin-releasing hormone, steroid receptors, and pituitary proopiomelanocortin immunohistochemically in 14 of these females at 6-13 years...
May 9, 2017: Aging
https://www.readbyqxmd.com/read/28490689/patient-derived-cells-modeling-pediatric-glioma
#13
Anna Wenger, Susanna Larsson, Helena Carén
No abstract text is available yet for this article.
May 8, 2017: Aging
https://www.readbyqxmd.com/read/28476022/aldh1a3-in-cscs
#14
Kelly E Sullivan, Richard A Cerione, Kristin F Wilson
No abstract text is available yet for this article.
May 3, 2017: Aging
https://www.readbyqxmd.com/read/28458256/aging-associated-oxidative-stress-inhibits-liver-progenitor-cell-activation-in-mice
#15
Yiji Cheng, Xue Wang, Bei Wang, Hong Zhou, Shipeng Dang, Yufang Shi, Li Hao, Qingquan Luo, Min Jin, Qianjun Zhou, Yanyun Zhang
Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, leading to the impaired liver regeneration...
April 29, 2017: Aging
https://www.readbyqxmd.com/read/28455974/strategies-for-hcc-target-discovery
#16
Pedro Molina-Sánchez, Amaia Lujambio
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455973/markers-of-arterial-health-could-serve-as-accurate-non-invasive-predictors-of-human-biological-and-chronological-age
#17
Alexander Fedintsev, Daria Kashtanova, Olga Tkacheva, Irina Strazhesko, Anna Kudryavtseva, Ancha Baranova, Alexey Moskalev
The decline in functional capacity is unavoidable consequence of the process of aging. While many anti-aging interventions have been proposed, clinical investigations into anti-aging medicine are limited by lack of reliable techniques for evaluating the rate of ageing. Here we present simple, accurate and cost-efficient techniques for estimation of human biological age, Male and Female Arterial Indices. We started with developing a model which accurately predicts chronological age. Using machine learning, we arrived on a set of four predictors, all of which reflect the functioning of the cardiovascular system...
April 2017: Aging
https://www.readbyqxmd.com/read/28455972/metabolism-microbiome-and-colorectal-cancer
#18
Somenath Datta, Sanjib Chowdhury, Hemant K Roy
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455971/2nd-interventions-in-aging-conference
#19
Brian K Kennedy, Linda Partridge
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455970/mitochondrial-replacement-in-an-ipsc-model-of-leber-s-hereditary-optic-neuropathy
#20
Raymond C B Wong, Shiang Y Lim, Sandy S C Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pébay
Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.
April 2017: Aging
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