journal
MENU ▼
Read by QxMD icon Read
search

Aging

journal
https://www.readbyqxmd.com/read/28904242/the-g-quadruplex-dna-stabilizing-drug-pyridostatin-promotes-dna-damage-and-downregulates-transcription-of-brca1-in-neurons
#1
Jose F Moruno-Manchon, Edward C Koellhoffer, Jayakrishnan Gopakumar, Shashank Hambarde, Nayun Kim, Louise D McCullough, Andrey S Tsvetkov
The G-quadruplex is a non-canonical DNA secondary structure formed by four DNA strands containing multiple runs of guanines. G-quadruplexes play important roles in DNA recombination, replication, telomere maintenance, and regulation of transcription. Small molecules that stabilize the G-quadruplexes alter gene expression in cancer cells. Here, we hypothesized that the G-quadruplexes regulate transcription in neurons. We discovered that pyridostatin, a small molecule that specifically stabilizes G-quadruplex DNA complexes, induced neurotoxicity and promoted the formation of DNA double-strand breaks (DSBs) in cultured neurons...
September 12, 2017: Aging
https://www.readbyqxmd.com/read/28904241/autophagic-responses-compensate-mitochondrial-impairments
#2
Vanessa Henkel, Verena Warnsmann, Heinz D Osiewacz
No abstract text is available yet for this article.
September 12, 2017: Aging
https://www.readbyqxmd.com/read/28898200/non-coding-transcriptome-in-brain-aging
#3
Thomas Arendt, Uwe Ueberham, Michael Janitz
No abstract text is available yet for this article.
September 12, 2017: Aging
https://www.readbyqxmd.com/read/28898201/aurka-inhibition-mimics-brcaness
#4
Jeff Hirst, Andrew K Godwin
No abstract text is available yet for this article.
September 11, 2017: Aging
https://www.readbyqxmd.com/read/28898202/toll-like-receptor-4-tlr4-deficient-mice-are-protected-from-adipose-tissue-inflammation-in-aging
#5
Amiya K Ghosh, Martin O'Brien, Theresa Mau, Raymond Yung
Adipose tissue (AT) inflammation is a central mechanism for metabolic dysfunction in both diet-induced obesity and age-associated obesity. Studies in diet-induced obesity have characterized the role of Fetuin A (Fet A) in Free Fatty Acids (FFA)-mediated TLR4 activation and adipose tissue inflammation. However, the role of Fet A & TLR4 in aging-related adipose tissue inflammation is unknown. In the current study, analysis of epidymymal fat pads of C57/Bl6 male mice, we found that, in contrast to data from diet-induced obesity models, adipose tissue from aged mice have normal Fet A and TLR4 expression...
September 7, 2017: Aging
https://www.readbyqxmd.com/read/28876223/rapamycin-in-mice
#6
William R Swindell
No abstract text is available yet for this article.
September 1, 2017: Aging
https://www.readbyqxmd.com/read/28758894/synergistic-sngi-tki-combination-against-lscs
#7
Xiaoyan Jiang
No abstract text is available yet for this article.
July 30, 2017: Aging
https://www.readbyqxmd.com/read/28758893/enhancing-er-stress-in-myeloma
#8
Craig T Wallington-Beddoe, Stuart M Pitson
No abstract text is available yet for this article.
July 30, 2017: Aging
https://www.readbyqxmd.com/read/28722657/amino-acid-metabolites-mtorc1-and-aging
#9
Henri Antikainen, Khoosheh Khayati, Radek Dobrowolski
No abstract text is available yet for this article.
July 17, 2017: Aging
https://www.readbyqxmd.com/read/28722658/the-golgi-localized-gamma-ear-containing-arf-binding-gga-protein-family-alters-alpha-synuclein-%C3%AE-syn-oligomerization-and-secretion
#10
Bjoern von Einem, Judith Eschbach, Martin Kiechle, Anke Wahler, Dietmar R Thal, Pamela J McLean, Jochen H Weishaupt, Albert C Ludolph, Christine A F von Arnim, Karin M Danzer
Several age-related neurodegenerative disorders are associated with protein misfolding and aggregation of toxic peptides. α-synuclein (α-syn) aggregation and the resulting cytotoxicity is a hallmark of Parkinson's disease (PD) as well as dementia with Lewy bodies. Rising evidence points to oligomeric and pre-fibrillar forms as the pathogenic species, and oligomer secretion seems to be crucial for the spreading and progression of PD pathology. Recent studies implicate that dysfunctions in endolysosomal/autophagosomal pathways increase α-syn secretion...
July 15, 2017: Aging
https://www.readbyqxmd.com/read/28722656/corrupting-the-dna-damage-response-a-critical-role-for-rad52-in-tumor-cell-survival
#11
Rachel Lieberman, Ming You
The DNA damage response enables cells to survive, maintain genome integrity, and to safeguard the transmission of high-fidelity genetic information. Upon sensing DNA damage, cells respond by activating this multi-faceted DNA damage response leading to restoration of the cell, senescence, programmed cell death, or genomic instability if the cell survives without proper repair. However, unlike normal cells, cancer cells maintain a marked level of genomic instability. Because of this enhanced propensity to accumulate DNA damage, tumor cells rely on homologous recombination repair as a means of protection from the lethal effect of both spontaneous and therapy-induced double-strand breaks (DSBs) in DNA...
July 15, 2017: Aging
https://www.readbyqxmd.com/read/28696945/correction-the-complex-genetics-of-gait-speed-genome-wide-meta-analysis-approach
#12
Dan Ben-Avraham, David Karasik, Joe Verghese, Kathryn L Lunetta, Jennifer A Smith, John D Eicher, Rotem Vered, Joris Deelen, Alice M Arnold, Aron S Buchman, Toshiko Tanaka, Jessica D Faul, Maria Nethander, Myriam Fornage, Hieab H Adams, Amy M Matteini, Michele L Callisaya, Albert V Smith, Lei Yu, Philip L De Jager, Denis A Evans, Vilmundur Gudnason, Albert Hofman, Alison Pattie, Janie Corley, Lenore J Launer, Davis S Knopman, Neeta Parimi, Stephen T Turner, Stefania Bandinelli, Marian Beekman, Danielle Gutman, Lital Sharvit, Simon P Mooijaart, David C Liewald, Jeanine J Houwing-Duistermaat, Claes Ohlsson, Matthijs Moed, Vincent J Verlinden, Dan Mellström, Jos N van der Geest, Magnus Karlsson, Dena Hernandez, Rebekah McWhirter, Yongmei Liu, Russell Thomson, Gregory J Tranah, Andre G Uitterlinden, David R Weir, Wei Zhao, John M Starr, Andrew D Johnson, M Arfan Ikram, David A Bennett, Steven R Cummings, Ian J Deary, Tamara B Harris, Sharon L R Kardia, Thomas H Mosley, Velandai K Srikanth, Beverly G Windham, Ann B Newman, Jeremy D Walston, Gail Davies, Daniel S Evans, Eline P Slagboom, Luigi Ferrucci, Douglas P Kiel, Joanne M Murabito, Gil Atzmon
No abstract text is available yet for this article.
July 7, 2017: Aging
https://www.readbyqxmd.com/read/28858850/mortalitypredictors-org-a-manually-curated-database-of-published-biomarkers-of-human-all-cause-mortality
#13
Maximus V Peto, Carlos De la Guardia, Ksenia Winslow, Andrew Ho, Kristen Fortney, Eric Morgen
Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers have resulted in numerous associations documented across hundreds of publications. Here, we present MortalityPredictors.org, a manually-curated, publicly accessible database, housing published, statistically-significant relationships between biomarkers and all-cause mortality in population-based or generally healthy samples...
August 31, 2017: Aging
https://www.readbyqxmd.com/read/28860413/the-transcriptome-of-cdk4-6-inhibition
#14
Erik S Knudsen, Agnieszka K Witkiewicz
No abstract text is available yet for this article.
August 30, 2017: Aging
https://www.readbyqxmd.com/read/28858849/neuroimaging-derived-brain-age-an-ageing-biomarker
#15
James H Cole
No abstract text is available yet for this article.
August 30, 2017: Aging
https://www.readbyqxmd.com/read/28854151/aging-effects-on-intestinal-homeostasis-associated-with-expansion-and-dysfunction-of-intestinal-epithelial-stem-cells
#16
Emily C Moorefield, Sarah F Andres, R Eric Blue, Laurianne Van Landeghem, Amanda T Mah, M Agostina Santoro, Shengli Ding
Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mice. Different levels of Sox9-EGFP permit analyses of active IESC (Sox9-EGFP(Low)), activatable reserve IESC and enteroendocrine cells (Sox9-EGFP(High)), Sox9-EGFP(Sublow) progenitors, and Sox9-EGFP(Negative) differentiated lineages. Crypt-villus morphology, cellular composition and apoptosis were measured by histology...
August 29, 2017: Aging
https://www.readbyqxmd.com/read/28854150/anti-aging-effects-of-coffee
#17
Keita Takahashi, Akihito Ishigami
No abstract text is available yet for this article.
August 29, 2017: Aging
https://www.readbyqxmd.com/read/28854149/chronic-exercise-reduces-hypothalamic-transforming-growth-factor-%C3%AE-1-in-middle-aged-obese-mice
#18
Vagner R R Silva, Carlos K Katashima, Luciene Lenhare, Carla G B Silva, Joseane Morari, Rafael L Camargo, Licio A Velloso, Mario A Saad, Adelino S R da Silva, Jose Rodrigo Pauli, Eduardo Rochete Ropelle
Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment...
August 28, 2017: Aging
https://www.readbyqxmd.com/read/28854148/a-new-opportunity-for-memri
#19
Ryan Cloyd, Moriel Vandsburger, Jose F Abisambra
No abstract text is available yet for this article.
August 28, 2017: Aging
https://www.readbyqxmd.com/read/28854147/novel-therapies-for-multiple-myeloma
#20
Craig T Wallington-Beddoe, Stuart M Pitson
No abstract text is available yet for this article.
August 28, 2017: Aging
journal
journal
42428
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"