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John Mitrofanis, Glen Jeffery
No abstract text is available yet for this article.
September 15, 2018: Aging
Fabian Kiessling
No abstract text is available yet for this article.
September 14, 2018: Aging
Pol Andrés-Benito, Raúl Domínguez, Maria J Colomina, Franc Llorens, Mònica Povedano, Isidre Ferrer
Amyotrophic lateral sclerosis (ALS) has variable clinical course and fatal outcome. Since inflammation plays a role in the pathogenesis of ALS, chitinase-3-like protein 1 or YKL40 has been assessed as putative biomarker of disease progression. YKL40 mRNA levels are increased in anterior horn of the spinal cord ( P= 0.004) in sporadic ALS (sALS) cases when compared with age-matched controls. These correlate with increased mRNA expression of microglial markers AIF1 and CD68 in the spinal cord in sALS ( P= 0.044 and P= 0...
September 13, 2018: Aging
Aniruddha Das, Myriam Gorospe, Amaresh C Panda
No abstract text is available yet for this article.
September 13, 2018: Aging
Bhavana Chhunchha, Eri Kubo, Prerna Singh, Dhirendra P Singh
Progressive deterioration of antioxidant response in aging is a major culprit in the initiation of age-related pathobiology induced by oxidative stress. We previously reported that oxidative stress leads to a marked reduction in transcription factor Sp1 and its mediated Prdx6 expression in lens epithelial cells (LECs) leading to cell death. Herein, we examined how Sp1 activity goes awry during oxidative stress/aging, and whether it is remediable. We found that Sp1 is hyper-Sumoylated at lysine (K) 16 residue in aging LECs...
September 12, 2018: Aging
Niels P Riksen, Mihai G Netea
No abstract text is available yet for this article.
September 12, 2018: Aging
Ting Lin, Yunong Fu, Xing Zhang, Jingxian Gu, Xiaohua Ma, Runchen Miao, Xiaohong Xiang, Wenquan Niu, Kai Qu, Chang Liu, Qifei Wu
Non-small cell lung cancer (NSCLC) is the most common cancer and cause of cancer-related mortality globally. Increasing evidence suggested that the long non-coding RNAs (lncRNAs) were involved in cancer-related death. To explore the possible prognostic lncRNA biomarkers for NSCLC patients, in the present study, we conducted a comprehensive lncRNA profiling analysis based on 1902 patients from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets. In the discovery phase, we employed 682 patients from the combination of four GEO datasets (GSE30219, GSE31546, GSE33745 and GSE50081) and conducted a seven-lncRNA formula to predict overall survival (OS)...
September 11, 2018: Aging
Stefano Savonitto, Nuccia Morici, Stefano De Servi
No abstract text is available yet for this article.
September 11, 2018: Aging
Francis Rodier, Daohong Zhou, Gerardo Ferbeyre
No abstract text is available yet for this article.
September 7, 2018: Aging
Feng Zhang, Ruyou Zhang, Xiaoyu Zhang, Yingnan Wu, Xiaoying Li, Shuang Zhang, Wenying Hou, Yu Ding, Jiawei Tian, Litao Sun, Xianchao Kong
Atherosclerosis is a chronic and multifactorial inflammatory disease and is closely associated with cardiovascular and cerebrovascular diseases. circRNAs can act as competing endogenous RNAs to mRNAs and function in various diseases. However, there is little known about the function of circRNAs in atherosclerosis. In this study, three rabbits in the case group were fed a high-fat diet to induce atherosclerosis and another three rabbits were fed a normal diet. To explore the biological functions of circRNAs in atherosclerosis, we analyzed the circRNA, miRNA and mRNA expression profiles using RNA-seq...
September 6, 2018: Aging
Bianca N Islam, Darren D Browning
No abstract text is available yet for this article.
September 5, 2018: Aging
Meng Dai, Yanlin Yu
No abstract text is available yet for this article.
September 5, 2018: Aging
Lijuan Hou, Xiaoxia Wei, Ya Zhuo, Lei Qin, Fang Yang, Lili Zhang, Xinwen Song
Depression is concomitantly presented in hepatitis B virus (HBV)-infected patients (HB). However, there is still no objective method to diagnose HBV-infected patients with depression (dHB). Therefore, in this study, a gas chromatography-mass spectrometry (GC-MS)-based metabolomic approach was employed to profile urine samples from 59 dHB and 52 HB (the training set) in order to identify urinary metabolite biomarkers for dHB. Then, 41 dHB and 35 HB (the testing set) were used to independently validate the diagnostic generalizability of these biomarkers...
September 2, 2018: Aging
Anil Can, Rose Du
No abstract text is available yet for this article.
August 31, 2018: Aging
Christopher M Evola, Tanner L Hudson, Luping Huang, Adrian M Corbett, Debra A Mayes
Recently epidemiological studies suggest females lose neuroprotection from neurodegenerative diseases as they go through menopause. It has been hypothesized that this neuroprotection is hormone-dependent. The current study characterized cell signaling molecules downstream of estrogen receptor beta that are known to play a role in memory, PKC, ERK, and connexin-43, in regions of the brain associated with memory decline in an attempt to elucidate significant changes that occur post-estrus. Total whole cell lysates were compared to isolated mitochondrial protein because mitochondrial function is known to be altered during aging...
August 31, 2018: Aging
Yoko Itakura, Norihiko Sasaki, Masashi Toyoda
Glycans are associated with and serve as biomarkers for various biological functions. We previously reported that cell surface sialylated glycoproteins of dermal fibroblasts decreased with cellular senescence and human aging. There is little information on the changes in glycoprotein expression and subcellular localization during the aging process. Here, we examined intracellular glycan profiles of fibroblasts undergoing cellular senescence and those derived from aging human subjects using lectin microarray analysis...
August 29, 2018: Aging
Rahul Damani
No abstract text is available yet for this article.
August 29, 2018: Aging
Monica Pibiri
The regenerative capacity of the liver after resection is reduced with aging. Recent studies on rodents revealed that both intracellular and extracellular factors are involved in the impairment of liver mass recovery during aging. Among the intracellular factors, age-dependent decrease of BubR1 (budding uninhibited by benzimidazole-related 1), YAP (Yes-associated protein) and SIRT1 (Sirtuin-1) have been associated to dampening of tissue reconstitution and inhibition of cell cycle genes following partial hepatectomy...
August 28, 2018: Aging
Qiu-Yue Zhai, Wei Ge, Jun-Jie Wang, Xiao-Feng Sun, Jin-Mei Ma, Jing-Cai Liu, Yong Zhao, Yan-Zhong Feng, Paul W Dyce, Massimo De Felici, Wei Shen
Zinc oxide nanoparticles (nZnO) have been shown to have higher toxic effects likely due to their ion-shedding ability and low solubility under neutral conditions. In order to investigate whether exposure to nZnO during embryonic development affects ovary development, 12.5 day post coitum (dpc) fetal mouse ovaries were cultured in the presence of nZnO for 6 days. We found that the nanoparticles (NPs) accumulated within the oocyte cytoplasm in a dose dependent manner, caused DNA damage and apoptosis, and result in a significant decrease in oocyte numbers...
August 28, 2018: Aging
Nataliya G Kolosova, Oyuna S Kozhevnikova, Darya V Telegina, Anzhela Zh Fursova, Natalia A Stefanova, Natalia A Muraleva, Franco Venanzi, Michael Y Sherman, Sergey I Kolesnikov, Albert A Sufianov, Vladimir L Gabai, Alexander M Shneider
P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. For example, previously we demonstrated that administration of p62/SQSTM1-encoding plasmid reduced chronic inflammation and alleviated osteoporosis and metabolic syndrome in animal models. Herein, we built upon these findings to investigate effect of the p62-encoding plasmid on an age-related macular degeneration (AMD), a progressive neurodegenerative ocular disease, using spontaneous retinopathy in senescence-accelerated OXYS rats as a model...
August 28, 2018: Aging
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