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Aging

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https://www.readbyqxmd.com/read/29140795/it-s-the-holes-that-matter
#1
Victoria C Cogger, Mashani Mohamad, David G Le Couteur
No abstract text is available yet for this article.
November 15, 2017: Aging
https://www.readbyqxmd.com/read/29140794/targeted-elimination-of-senescent-ras-transformed-cells-by-suppression-of-mek-erk-pathway
#2
Elena Y Kochetkova, Galina I Blinova, Olga A Bystrova, Marina G Martynova, Valery A Pospelov, Tatiana V Pospelova
The Ras-Raf-MEK-ERK pathway plays a central role in tumorigenesis and is a target for anticancer therapy. The successful strategy based on the activation of cell death in Ras-expressing cells is associated with the suppression of kinases involved in Ras pathway. However, activation of cytoprotective autophagy overcomes antiproliferative effect of the inhibitors and develops drug resistance. We studied whether cellular senescence induced by HDAC inhibitor sodium butyrate in E1a+cHa-Ras-transformed rat embryo fibroblasts (ERas) and A549 human Ki-Ras mutated lung adenocarcinoma cells would enhance the tumor suppressor effect of MEK/ERK inhibition...
November 14, 2017: Aging
https://www.readbyqxmd.com/read/29135454/expression-of-a-novel-cnpy2-isoform-in-colorectal-cancer-and-its-association-with-oncologic-prognosis
#3
Jianhong Peng, Qingjian Ou, Jian Guo, Zhizhong Pan, Rongxin Zhang, Xiaojun Wu, Yujie Zhao, Yuxiang Deng, Caixia Li, Fulong Wang, Liren Li, Gong Chen, Zhenhai Lu, Peirong Ding, Desen Wan, Yujing Fang
Colorectal cancer (CRC) is a leading cause of cancer-related mortality. Recently, we identified a novel biomarker, canopy fibroblast growth factor signaling regulator 2 (CNPY2) isoform2, and subsequently investigated its expression and prognostic value in CRC patients. We initially generated CNPY2 isoform2 monoclonal antibodies and examined CNPY2 isoform2 expression in CRC cell lines and tissues using quantitative real-time polymerase chain reaction, western blot and immunohistochemistry analyses. We found that CNPY2 isoform2 expression significantly increased in tumor cell lines and tissues compared with that in normal colon epithelial cells and tumor-adjacent normal tissues...
November 13, 2017: Aging
https://www.readbyqxmd.com/read/29135455/transcriptome-wide-association-study-of-inflammatory-biologic-age
#4
Honghuang Lin, Kathryn L Lunetta, Qiang Zhao, Jian Rong, Emelia J Benjamin, Michael M Mendelson, Roby Joehanes, Daniel Levy, Martin G Larson, Joanne M Murabito
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the Klemera-Doubal method to estimate inflammatory biologic age and we computed the difference (∆Age) between biologic age and chronologic age. Gene expression in whole blood was measured using the Affymetrix Human Exon 1...
November 11, 2017: Aging
https://www.readbyqxmd.com/read/29129831/identification-of-new-genetic-variants-of-hla-dqb1-associated-with-human-longevity-and-lipid-homeostasis-a-cross-sectional-study-in-a-chinese-population
#5
Fan Yang, Liang Sun, Xiaoquan Zhu, Jing Han, Yi Zeng, Chao Nie, Huiping Yuan, Xiaoling Li, Xiaohong Shi, Yige Yang, Caiyou Hu, Zeping Lv, Zezhi Huang, Chenguang Zheng, Siying Liang, Jin Huang, Gang Wan, Keyan Qi, Bin Qin, Suyan Cao, Xin Zhao, Yongqiang Zhang, Ze Yang
Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear. As longevity population is a good healthy aging model for understanding how the body begin aging and the process of aging, and plasma lipids metabolism and balance is a very important to life maintain and physiologic functional turnover. It is important to explore how the effect of genetic variants associated long-life individuals on lipids metabolism and balance. Therefore, we developed a comparative study based population which contains 2816 longevity and 2819 control...
November 10, 2017: Aging
https://www.readbyqxmd.com/read/29129830/psychological-stress-exposure-to-aged-mice-causes-abnormal-feeding-patterns-with-changes-in-the-bout-number
#6
Chihiro Yamada, Sachiko Mogami, Tomohisa Hattori
Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum feeding behavior parameters) in aged mice. Feeding behaviors of C57BL/6J mice were monitored for 24 h by an automatic monitoring device. Novelty stress reduced the meal amount over the 24 h in both young and aged mice, but as a result of a time course study it was persistent in aged mice...
November 9, 2017: Aging
https://www.readbyqxmd.com/read/29112501/triple-threat-adiposity-aging-atrial-fibrillation
#7
Justus M Anumonwo, José Jalife, Daniel R Goldstein
No abstract text is available yet for this article.
November 1, 2017: Aging
https://www.readbyqxmd.com/read/29084933/how-the-cell-cycle-enforces-senescence
#8
Helena Silva Cascales, Erik Müllers, Arne Lindqvist
No abstract text is available yet for this article.
October 30, 2017: Aging
https://www.readbyqxmd.com/read/29081403/sirt4-interacts-with-opa1-and-regulates-mitochondrial-quality-control-and-mitophagy
#9
Alexander Lang, Ruchika Anand, Simone Altinoluk-Hambüchen, Hakima Ezzahoini, Anja Stefanski, Afshin Iram, Laura Bergmann, Jennifer Urbach, Philip Böhler, Jan Hänsel, Manuel Franke, Kai Stühler, Jean Krutmann, Jürgen Scheller, Björn Stork, Andreas S Reichert, Roland P Piekorz
The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD(+)-dependent manner and is implicated in cellular senescence and aging. Here we reveal a novel function of SIRT4 in mitochondrial morphology/quality control and regulation of mitophagy. We report that moderate overexpression of SIRT4, but not its enzymatically inactive mutant H161Y, sensitized cells to mitochondrial stress. CCCP-triggered dissipation of the mitochondrial membrane potential resulted in increased mitochondrial ROS levels and autophagic flux, but surprisingly led to increased mitochondrial mass and decreased Parkin-regulated mitophagy...
October 29, 2017: Aging
https://www.readbyqxmd.com/read/29081404/socs1-regulates-senescence-and-ferroptosis-by-modulating-the-expression-of-p53-target-genes
#10
Emmanuelle Saint-Germain, Lian Mignacca, Mathieu Vernier, Diwakar Bobbala, Subburaj Ilangumaran, Gerardo Ferbeyre
The mechanism by which p53 suppresses tumorigenesis remains poorly understood. In the context of aberrant activation of the JAK/STAT5 pathway, SOCS1 is required for p53 activation and the regulation of cellular senescence. In order to identify p53 target genes acting during the senescence response to oncogenic STAT5A, we characterized the transcriptome of STAT5A-expressing cells after SOCS1 inhibition. We identified a set of SOCS1-dependent p53 target genes that include several secreted proteins and genes regulating oxidative metabolism and ferroptosis...
October 28, 2017: Aging
https://www.readbyqxmd.com/read/29080556/a-new-mutation-independent-approach-to-cancer-therapy-inhibiting-oncogenic-ras-and-myc-by-targeting-mitochondrial-biogenesis
#11
Bela Ozsvari, Federica Sotgia, Michael P Lisanti
Here, we used MCF7 cells as a model system to interrogate how MYC/RAS co-operativity contributes to metabolic flux and stemness in breast cancer cells. We compared the behavior of isogenic MCF7 cell lines transduced with c-Myc or H-Ras (G12V), either individually or in combination. Cancer stem cell (CSC) activity was measured using the mammosphere assay. c-Myc augmented both mammosphere formation and mitochondrial respiration, without any effects on glycolytic flux. In contrast, H-Ras (G12V) synergistically augmented both mammosphere formation and glycolysis, but only in combination with c-Myc, directly demonstrating MYC/RAS co-operativity...
October 27, 2017: Aging
https://www.readbyqxmd.com/read/29080555/circular-association-of-hypoglycemia-with-dementia
#12
Devi Meyyappan, James S Goodwin, Hemalkumar B Mehta
No abstract text is available yet for this article.
October 27, 2017: Aging
https://www.readbyqxmd.com/read/29080554/loxl2-as-a-protective-in-osteoarthritis-cartilage
#13
Manish V Bais, Mary B Goldring
No abstract text is available yet for this article.
October 27, 2017: Aging
https://www.readbyqxmd.com/read/29074822/degeneration-of-the-osteocyte-network-in-the-c57bl-6-mouse-model-of-aging
#14
LeAnn M Tiede-Lewis, Yixia Xie, Molly A Hulbert, Richard Campos, Mark R Dallas, Vladimir Dusevich, Lynda F Bonewald, Sarah L Dallas
Age-related bone loss and associated fracture risk are major problems in musculoskeletal health. Osteocytes have emerged as key regulators of bone mass and as a therapeutic target for preventing bone loss. As aging is associated with changes in the osteocyte lacunocanalicular system, we focused on the responsible cellular mechanisms in osteocytes. Bone phenotypic analysis was performed in young-(5mo) and aged-(22mo) C57BL/6 mice and changes in bone structure/geometry correlated with alterations in osteocyte parameters determined using novel multiplexed-3D-confocal imaging techniques...
October 26, 2017: Aging
https://www.readbyqxmd.com/read/29074821/-anti-parallel-evolution-of-lifespan
#15
Arne Sahm, Alessandro Cellerino
No abstract text is available yet for this article.
October 26, 2017: Aging
https://www.readbyqxmd.com/read/29074820/can-aging-be-beneficial
#16
Stephen Frenk, Jonathan Houseley
No abstract text is available yet for this article.
October 26, 2017: Aging
https://www.readbyqxmd.com/read/29070732/thyroid-status-and-mortality-in-nonagenarians-from-long-lived-families-and-the-general-population
#17
Nicolien A van Vliet, Evie van der Spoel, Marian Beekman, P Eline Slagboom, Gerard Jan Blauw, Jacobijn Gussekloo, Rudi G J Westendorp, Diana van Heemst
The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data...
October 25, 2017: Aging
https://www.readbyqxmd.com/read/29070731/neuronal-tetraploidy-in-alzheimer-and-aging
#18
José M Frade, Noelia López-Sánchez
No abstract text is available yet for this article.
October 25, 2017: Aging
https://www.readbyqxmd.com/read/29070730/a-novel-caloric-restriction-mediator
#19
Masaki Kobayashi, Yoshikazu Higami
No abstract text is available yet for this article.
October 25, 2017: Aging
https://www.readbyqxmd.com/read/29064821/senescence-associated-ultrastructural-features-of-long-term-cultures-of-induced-pluripotent-stem-cells-ipscs
#20
Fiorella Colasuonno, Rossella Borghi, Alessia Niceforo, Maurizio Muzzi, Enrico Bertini, Andrea Di Giulio, Sandra Moreno, Claudia Compagnucci
Induced pluripotent stem cells (iPSCs) hold great promise for developing personalized regenerative medicine, however characterization of their biological features is still incomplete. Moreover, changes occurring in long-term cultured iPSCs have been reported, suggesting these as a model of cellular aging. For this reason, we addressed the ultrastructural characterization of iPSCs, with a focus on possible time-dependent changes, involving specific cell compartments. To this aim, we comparatively analysed cultures at different timepoints, by an innovative electron microscopic technology (FIB/SEM)...
October 23, 2017: Aging
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