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Aging

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https://www.readbyqxmd.com/read/28522793/diffuse-colonies-of-human-skin-fibroblasts-in-relation-to-cellular-senescence-and-proliferation
#1
Vadim Zorin, Alla Zorina, Nadezhda Smetanina, Pavel Kopnin, Ivan V Ozerov, Sergey Leonov, Artur Isaev, Dmitry Klokov, Andreyan N Osipov
Development of personalized skin treatment in medicine and skin care may benefit from simple and accurate evaluation of the fraction of senescent skin fibroblasts that lost their proliferative capacity. We examined whether enriched analysis of colonies formed by primary human skin fibroblasts, a simple and widely available cellular assay, could reveal correlations with the fraction of senescent cells in heterogenic cell population. We measured fractions of senescence associated β-galactosidase (SA-βgal) positive cells in either mass cultures or colonies of various morphological types (dense, mixed and diffuse) formed by skin fibroblasts from 10 human donors...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28522792/transgenic-autoinhibition-of-p21-activated-kinase-exacerbates-synaptic-impairments-and-fronto-dependent-behavioral-deficits-in-an-animal-model-of-alzheimer-s-disease
#2
Cyril Bories, Dany Arsenault, Myriam Lemire, Cyntia Tremblay, Yves De Koninck, Frédéric Calon
Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expression, particularly with symptoms related to frontal cortex dysfunction. To investigate the role of PAK combined with Aβ and tau pathologies (3xTg-AD mice) in the frontal cortex, we generated a transgenic model of AD with a deficit in PAK activity (3xTg-AD-dnPAK mice)...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28490691/the-puzzling-interplay-between-p53-and-sp1
#3
Ariella Oppenheim, Galit Lahav
No abstract text is available yet for this article.
May 9, 2017: Aging
https://www.readbyqxmd.com/read/28490690/a-decline-in-female-baboon-hypothalamo-pituitary-adrenal-axis-activity-anticipates-aging
#4
Shanshan Yang, Kenneth G Gerow, Hillary F Huber, McKenna M Considine, Cun Li, Vicki Mattern, Anthony G Comuzzie, Stephen P Ford, Peter W Nathanielsz
Stressors that disrupt homeostasis advance aging. Glucocorticoids regulate multiple processes that determine the aging trajectory. Debate exists regarding life-course circulating glucocorticoid concentrations. Rodent and nonhuman primate studies indicate circulating glucocorticoids fall from early life. We measured fasting morning cortisol in 24 female baboons (6-21 years, human equivalent ~18-70). We also quantified hypothalamic paraventricular nuclear (PVN) arginine vasopressin (AVP), corticotropin-releasing hormone, steroid receptors, and pituitary proopiomelanocortin immunohistochemically in 14 of these females at 6-13 years...
May 9, 2017: Aging
https://www.readbyqxmd.com/read/28490689/patient-derived-cells-modeling-pediatric-glioma
#5
Anna Wenger, Susanna Larsson, Helena Carén
No abstract text is available yet for this article.
May 8, 2017: Aging
https://www.readbyqxmd.com/read/28476022/aldh1a3-in-cscs
#6
Kelly E Sullivan, Richard A Cerione, Kristin F Wilson
No abstract text is available yet for this article.
May 3, 2017: Aging
https://www.readbyqxmd.com/read/28458256/aging-associated-oxidative-stress-inhibits-liver-progenitor-cell-activation-in-mice
#7
Yiji Cheng, Xue Wang, Bei Wang, Hong Zhou, Shipeng Dang, Yufang Shi, Li Hao, Qingquan Luo, Min Jin, Qianjun Zhou, Yanyun Zhang
Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, leading to the impaired liver regeneration...
May 1, 2017: Aging
https://www.readbyqxmd.com/read/28455974/strategies-for-hcc-target-discovery
#8
Pedro Molina-Sánchez, Amaia Lujambio
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455973/markers-of-arterial-health-could-serve-as-accurate-non-invasive-predictors-of-human-biological-and-chronological-age
#9
Alexander Fedintsev, Daria Kashtanova, Olga Tkacheva, Irina Strazhesko, Anna Kudryavtseva, Ancha Baranova, Alexey Moskalev
The decline in functional capacity is unavoidable consequence of the process of aging. While many anti-aging interventions have been proposed, clinical investigations into anti-aging medicine are limited by lack of reliable techniques for evaluating the rate of ageing. Here we present simple, accurate and cost-efficient techniques for estimation of human biological age, Male and Female Arterial Indices. We started with developing a model which accurately predicts chronological age. Using machine learning, we arrived on a set of four predictors, all of which reflect the functioning of the cardiovascular system...
April 2017: Aging
https://www.readbyqxmd.com/read/28455972/metabolism-microbiome-and-colorectal-cancer
#10
Somenath Datta, Sanjib Chowdhury, Hemant K Roy
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455971/2nd-interventions-in-aging-conference
#11
Brian K Kennedy, Linda Partridge
No abstract text is available yet for this article.
April 2017: Aging
https://www.readbyqxmd.com/read/28455970/mitochondrial-replacement-in-an-ipsc-model-of-leber-s-hereditary-optic-neuropathy
#12
Raymond C B Wong, Shiang Y Lim, Sandy S C Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pébay
Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem cells (iPSCs) were generated subsequently. Retinal ganglion cell (RGC) differentiation demonstrates increased cell death in LHON-RGCs and can be rescued in cybrid corrected RGCs.
April 2017: Aging
https://www.readbyqxmd.com/read/28455969/bmp2-promotes-proliferation-and-invasion-of-nasopharyngeal-carcinoma-cells-via-mtorc1-pathway
#13
Meng-He Wang, Xiao-Min Zhou, Mei-Yin Zhang, Lu Shi, Ruo-Wen Xiao, Li-Si Zeng, Xian-Zi Yang, X F Steven Zheng, Hui-Yun Wang, Shi-Juan Mai
Bone morphogenetic protein-2 (BMP2) is a secreted protein that highly expressed in a variety of cancers and contributes to cell proliferation, migration, invasiveness, mobility, metastasis and EMT. However, its clinical significance and biological function in nasopharyngeal carcinoma (NPC) remain unknown up to now. Up-regulation of BMP2 was first observed in NPC cell lines by a genome-wide transcriptome analysis in our previous study. In this study, BMP2 mRNA was detected by qRT-PCR and data showed that it was upregulated in NPC compared with non-cancerous nasopharynx samples...
April 2017: Aging
https://www.readbyqxmd.com/read/28448963/paradoxical-aging-in-hiv-immune-senescence-of-b-cells-is-most-prominent-in-young-age
#14
Stefano Rinaldi, Suresh Pallikkuth, Varghese K George, Lesley R de Armas, Rajendra Pahwa, Celeste M Sanchez, Maria Fernanda Pallin, Li Pan, Nicola Cotugno, Gordon Dickinson, Allan Rodriguez, Margaret Fischl, Maria Alcaide, Louis Gonzalez, Paolo Palma, Savita Pahwa
Combination antiretroviral therapies (cART)can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group. Although HIV and aging are independently associated with impaired humoral immunity, immune status in people aging with HIV is relatively unexplored. In this study influenza vaccination was used to probe age associated perturbations in the B cell compartment of HIV-negative "healthy controls" (HC) and virologically controlled HIV-infected participants on cART (HIV) (n=124), grouped by age as young (<40 yrs), middle-aged (40-59yrs) or old (>60 yrs)...
April 2017: Aging
https://www.readbyqxmd.com/read/28448962/progressive-changes-in-non-coding-rna-profile-in-leucocytes-with-age
#15
Maider Muñoz-Culla, Haritz Irizar, Ana Gorostidi, Ainhoa Alberro, Iñaki Osorio-Querejeta, Javier Ruiz-Martínez, Javier Olascoaga, Adolfo López de Munain, David Otaegui
It has been observed that immune cell deterioration occurs in the elderly, as well as a chronic low-grade inflammation called inflammaging. These cellular changes must be driven by numerous changes in gene expression and in fact, both protein-coding and non-coding RNA expression alterations have been observed in peripheral blood mononuclear cells from elder people. In the present work we have studied the expression of small non-coding RNA (microRNA and small nucleolar RNA -snoRNA-) from healthy individuals from 24 to 79 years old...
April 2017: Aging
https://www.readbyqxmd.com/read/28446712/aspirin-inhibits-the-shh-gli1-signaling-pathway-and-sensitizes-malignant-glioma-cells-to-temozolomide-therapy
#16
Jianguang Ming, Bo Sun, Ziwei Li, Lin Lin, Xiangqi Meng, Bo Han, Ruijia Wang, Pengfei Wu, Jianlong Li, Jinquan Cai, Chuanlu Jiang
Aberrant activation of sonic hedgehog (SHH)/glioma-associated oncogene homolog 1 (GLI1) pathway plays an important role in the tumorigenicity of malignant glioma cells and resistance to temozolomide (TMZ). Here we investigated the aspirin's antineoplastic molecular route by targeting SHH/GLI1 pathway and examined the feasibility of aspirin combined with TMZ therapy. Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) revealed that the activity of the SHH/GLI1 pathway was strongly inhibited by aspirin...
April 2017: Aging
https://www.readbyqxmd.com/read/28439047/functional-human-grin2b-promoter-polymorphism-and-variation-of-mental-processing-speed-in-older-adults
#17
Yang Jiang, Ming Kuan Lin, Gregory A Jicha, Xiuhua Ding, Sabrina L McIlwrath, David W Fardo, Lucas S Broster, Frederick A Schmitt, Richard Kryscio, Robert H Lipsky
We investigated the role of a single nucleotide polymorphism rs3764030 (G>A) within the human GRIN2B promoter in mental processing speed in healthy, cognitively intact, older adults. In vitro DNA-binding and reporter gene assays of different allele combinations in transfected cells showed that the A allele was a gain-of-function variant associated with increasing GRIN2B mRNA levels. We tested the hypothesis that individuals with A allele will have better memory performance (i.e. faster reaction times) in older age...
April 2017: Aging
https://www.readbyqxmd.com/read/28437250/ionizing-radiation-reduces-adam10-expression-in-brain-microvascular-endothelial-cells-undergoing-stress-induced-senescence
#18
Lucinda S McRobb, Matthew J McKay, Jennifer R Gamble, Michael Grace, Vaughan Moutrie, Estevam D Santos, Vivienne S Lee, Zhenjun Zhao, Mark P Molloy, Marcus A Stoodley
Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular endothelium are particularly susceptible to radiation and play an important role in brain homeostasis, we investigated radiation-induced senescence in brain microvascular endothelial cells (EC). Using biotinylation to label surface proteins, streptavidin enrichment and proteomic analysis, we analyzed the surface proteome of stress-induced senescent EC in culture...
April 2017: Aging
https://www.readbyqxmd.com/read/28437249/the-differential-spatiotemporal-expression-pattern-of-shelterin-genes-throughout-lifespan
#19
Kay-Dietrich Wagner, Yilin Ying, Waiian Leong, Jie Jiang, Xuefei Hu, Yi Chen, Jean-François Michiels, Yiming Lu, Eric Gilson, Nicole Wagner, Jing Ye
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined...
April 2017: Aging
https://www.readbyqxmd.com/read/28437248/protective-effect-of-calretinin-on-testicular-leydig-cells-via-the-inhibition-of-apoptosis
#20
Wendan Xu, Qian Zhu, Bei Zhang, Shan Liu, Xiaonan Dai, Chao Gao, Li Gao, Yugui Cui
The core mechanism of Late-onset hypogonadism (LOH) is the deficiency of androgen due to the functional and quantitative decline of testicular Leydig cells. Here we explored the protective effect of calretinin, a Ca(2+)-binding protein, on Leydig cells. We found in MLTC-1 cells transfected with LV-calb2, the cell viability and optical density (OD) were higher (p<0.05), cells in the S phase of the cell cycle were increased (p<0.01) and p-ERK1/2 and p-AKT levels were significantly higher (p<0.01 and p<0...
April 2017: Aging
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