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Emma Anderson, Alice Cochrane, Jean Golding, Stephen Nowicki
Few modifiable risk factors for cognitive decline have been identified. Despite an external locus of control (LoC) being adversely associated with many psychological and physical health outcomes, few studies have examined whether it is related to cognitive function in adulthood. In 1178 women from the Avon Longitudinal Study of Parents and Children, we examined whether LoC, and change in LoC over time, is associated with cognitive function in midlife. LoC was prospectively measured at mean ages 30 and 48 years using the validated Nowicki-Strickland scale...
July 12, 2018: Aging
Shun-Feng Cheng, Xun-Si Qin, Ze-Li Han, Xiao-Feng Sun, Yan-Ni Feng, Fan Yang, Wei Ge, Lan Li, Yong Zhao, Massimo De Felici, Shu-Hua Zou, Yi Zhou, Wei Shen
In the present paper, we found that human fetal ovaries (at ~16 weeks) express the transcripts for several subunits of the nicotinic acetylcholine receptor (nAChR). Exposure to the drug in vitro resulted in the marked increase of apoptosis in the ovaries in a time and dose-dependent manner. Evidence that adverse nicotine effects are potentially due to an increased level of reactive oxygen species (ROS) and consequent DNA damage, both in the ovarian somatic cells and germ cells, are reported. After 4 days of culture, exposure to 1 mM and 10 mM nicotine caused a 50% and 75% decrease, respectively, in the number of oogonia/oocytes present in the fetal ovaries...
July 12, 2018: Aging
Nicola Alessio, Antonietta Stellavato, Tiziana Squillaro, Stefania Del Gaudio, Giovanni Di Bernardo, Gianfranco Peluso, Mario De Rosa, Chiara Schiraldi, Umberto Galderisi
Mesenchymal stem cells, a subpopulation of mesenchymal stromal cells (MSCs), are present in the stroma of several tissues. MSC in vitro cultivation for clinical treatments may greatly affect MSC properties. A primary handicap is replicative senescence that impairs MSC functions. Hyaluronan (HA) is present in the extracellular matrix that composes the stem cell niche environment and is under investigation as a key factor for in vitro stem cell growth. We evaluated the effect on MSC cultivation of HA hybrid cooperative complexes (HCC) that are obtained from high (H) and low (L) weight molecules (NAHYCO™)...
July 12, 2018: Aging
Oleg Podgorny, Natalia Peunova, Grigori Enikolopov
No abstract text is available yet for this article.
July 1, 2018: Aging
Qiuling Sang, Xiaoyang Liu, Libo Wang, Ling Qi, Wenping Sun, Weiyao Wang, Yajuan Sun, Haina Zhang
We aimed to explore the mechanism of pramipexole (PPX) actions in the treatment of Parkinson's disease (PD). Genes related to PD and PPX were screened through bioinformatics retrieval. The PD model was constructed by applying 1-methyl-4-phenylpyridinium (MMP+). The RNA expression levels of circSNCA, SNCA , apoptosis-related genes ( BCL2 , CASP3 , BAX , PTEN and P53 ) and miR-7 were detected by qRT-PCR. Protein expression was determined by western blot. The interactions between circSNCA-miR-7- SNCA were verified by dual luciferase assay and immunofluorescence localization...
June 28, 2018: Aging
Chi Yang, Ying Jiao, Bing Wei, Zeyi Yang, Jin-Fu Wu, Jorgen Jensen, Wei-Horng Jean, Chih-Yang Huang, Chia-Hua Kuo
It remains unclear how exercise, as an entropic event, brings benefit against human aging. Here we examined longitudinal changes of p16Ink4a+ senescent cells in skeletal muscle of young men (aged 22.5±1.7 y) before and after resistance exercise (0 h and 48 h) with multiple biopsies at two different protein availabilities: low protein (14%) and isocaloric high protein (44%) supplemented conditions. Immunohistochemistry analysis of muscle cross-sections using p16Ink4a and CD34 antibodies confirmed that the detected senescent cells were endothelial progenitor cells...
June 27, 2018: Aging
Xinwei Geng, Xiaohui Wang, Man Luo, Meichun Xing, Yinfang Wu, Wen Li, Zhihua Chen, Huahao Shen, Songmin Ying
Background Environmental particulate matter exposure can cause various respiratory problems including aggravated asthma, decreased lung function and increased respiratory symptoms. However, the molecular mechanisms underlying PM-induced lung inflammation are incompletely understood. Effective therapeutic strategies are required. Results A mouse model of particulate matter-induced lung inflammation was used to identify the pathology and the molecular mechanisms for particulate matter-induced lung inflammation...
June 26, 2018: Aging
Qiongye Dong, Lei Wei, Michael Q Zhang, Xiaowo Wang
Dysregulation of mRNA splicing has been observed in certain cellular senescence process. However, the common splicing alterations on the whole transcriptome shared by various types of senescence are poorly understood. In order to systematically identify senescence-associated transcriptomic changes in genome-wide scale, we collected RNA sequencing datasets of different human cell types with a variety of senescence-inducing methods from public databases and performed meta-analysis. First, we discovered that a group of RNA binding proteins were consistently down-regulated in diverse senescent samples and identified 406 senescence-associated common differential splicing events...
June 24, 2018: Aging
Ronghan Liu, Wenzhao Wang, Shuya Wang, Wei Xie, Hongfei Li, Bin Ning
Astrogliosis following spinal cord injury (SCI) was considered as a negative factor for neural regeneration. We found that miR-21 was significantly upregulated after SCI. So, we aim to determine whether miR-21 acts in a positive manner post SCI. In vitro , we measured the proliferation, apoptosis and cytokine secretion of primary cultured astrocytes after modulating the expression of miR-21 by western blot, RT-PCR and immunofluorescence. In vivo , we performed a modified Allen's weight drop model. Manipulation of the miR-21 expression level was achieved by interfering with antagomir and agomir...
June 23, 2018: Aging
Marie Kveiborg, Gary Thomas
No abstract text is available yet for this article.
June 22, 2018: Aging
Manoj Nepal, Chi Ma, Guoxiang Xie, Wei Jia, Peiwen Fei
Given importance of 22-Fanconi Anemia (FA) proteins together to act in a signaling pathway in preventing deleterious clinical symptoms, e.g. severe bone marrow failure, congenital defects, an early onset of aging and cancer, studies on each FA protein become increasingly attractive. However, an unbiased and systematic investigation of cellular effects resulting from each FA protein is missing. Here, we report roles of FA complementation C group protein (FANCC) in the protection from metabolic disorders. This study was prompted by the diabetes-prone feature displayed in FANCC knockout mice, which is not typically shown in patients with FA...
June 21, 2018: Aging
Yafei Ye, Shengnan Yang, Yanping Han, Jingjing Sun, Lijuan Xv, Lina Wu, Yongfeng Wang, Liang Ming
Long intergenic non-coding RNA Linc00472 has been considered as a tumor suppressor in some cancers. However, the function and mechanism of Linc00472 in colorectal cancer has not been well elucidated. In this study, we found that Linc00472 was down-regulated in colorectal cancer tissues and cells. Elevated Linc00472 expression suppressed proliferation and induced apoptosis in colorectal cancer cells. Moreover, Linc00472 acted as a competing endogenous RNA (ceRNA) of miR-196a to release programmed cell death 4 (PDCD4)...
June 21, 2018: Aging
Alexei Evdokimov, Mikhail Kutuzov, Irina Petruseva, Natalia Lukjanchikova, Elena Kashina, Ekaterina Kolova, Tatyana Zemerova, Svetlana Romanenko, Polina Perelman, Dmitry Prokopov, Andrei Seluanov, Vera Gorbunova, Alexander Graphodatsky, Vladimir Trifonov, Svetlana Khodyreva, Olga Lavrik
Naked mole rat (NMR) is the long-lived and tumor-resistant rodent. NMRs possess multiple adaptations that may contribute to longevity and cancer-resistance. However, whether NMRs have more efficient DNA repair have not been directly tested. Here we compared base excision repair (BER) and nucleotide excision repair (NER) systems in extracts from NMR and mouse fibroblasts after UVC irradiation. Transcript levels of the key repair enzymes demonstrated in most cases higher inducibility in the mouse vs the NMR cells...
June 20, 2018: Aging
Hongyuan Wang, Zhizhou Zhang, David Gems
No abstract text is available yet for this article.
June 19, 2018: Aging
Paul Chuchana, Anne-Laure Mausset-Bonnefont, Marc Mathieu, Francisco Espinoza, Marisa Teigell, Karine Toupet, Chantal Ripoll, Farida Djouad, Danièle Noel, Christian Jorgensen, Jean-Marc Brondello
Progressive loss of tissue homeostasis is a hallmark of numerous age-related pathologies, including osteoarthritis (OA). Accumulation of senescent chondrocytes in joints contributes to the age-dependent cartilage loss of functions through the production of hypertrophy-associated catabolic matrix-remodeling enzymes and pro-inflammatory cytokines. Here, we evaluated the effects of the secreted variant of the anti-aging hormone α-Klotho on cartilage homeostasis during both cartilage formation and OA development...
June 19, 2018: Aging
Qizhi Cao, Shude Yang, Qing Lv, Yan Liu, Li Li, Xiaojie Wu, Guiwu Qu, Xiaoli He, Xiaoshu Zhang, Shuqin Sun, Boqing Li, Jing An, Tao Hu, Jiangnan Xue
Human leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), an immunoinhibitory receptor, is expressed on most types of hematopoietic cells and some tumor cells. LAIR-1 plays an inhibitory role in immune cell maturation, differentiation, and activation. LAIR-1 is also involved in some autoimmune diseases and tumors. However, the mechanism controlling the regulation of the LAIR-1 gene is still unknown. In order to elucidate the molecular mechanisms involved in LAIR-1 regulation, in the present study, we cloned and characterized the promoter region of LAIR-1 gene using a series of truncated promoter plasmids in luciferase reporter assays...
June 18, 2018: Aging
Jin Zhang, Lixiao Yang, Xiaohong Xiang, Zhuoying Li, Kai Qu, Ke Li
Ovarian cancer yields the highest mortality rate of all lethal gynecologic cancers, and the prognosis is unsatisfactory with the major obstacle in resistance to chemotherapy. The generation of reactive oxygen species (ROS) in tumor tissues was associated with chemotherapeutic effectiveness by mediating cellular longevity. In this study, we screened the prognostic values of oxidative stress-related genes in ovarian cancer patients received platinum-based chemotherapy, and conducted a prognostic gene signature composing of three genes, TXNRD1, GLA and GSTZ1 ...
June 17, 2018: Aging
Zhi-Ming Dai, Jian-Rui Lv, Kang Liu, Xiao-Ming Lei, Wei Li, Gang Wu, Xing-Han Liu, Yu-Xiao Zhu, Qian Hao, Zhi-Jun Dai
The role of rs4919510 polymorphism in microRNA-608 (miR-608) and cancer susceptibility and prognosis remain controversial and debatable. We conducted a meta-analysis of twenty-four eligible publications on the association of rs4919510 polymorphism with cancer risk and/or prognosis. Odds ratios, hazard ratios, and 95% confidence interval were used to investigate the association between this polymorphism and susceptibility, overall survival, and recurrence-free survival of cancer. Overall, eighteen case-control studies and nine cohort studies evaluated the susceptibility and prognostic value of rs4919510 polymorphism in cancer, respectively...
June 16, 2018: Aging
Diangeng Li, Delong Zhao, Weiguang Zhang, Qian Ma, Dong Liu, Qi Huang, Ying Zheng, Xueyuan Bai, Xuefeng Sun, Xiangmei Chen
We established a young (Y)-old (O) rat kidney transplantation model. With this model, we detected no age-related differences in renal structure between Y→Y and Y→O kidneys or O→O and O→Y kidneys. However, we did detect differences in levels of the senescence markers β-gal and p16 as well as the inflammatory cytokines TNF-α and IL-1β. Using proteomics analysis we detected 66 proteins associated with suppression of aging and 73 proteins associated with enhancement of aging. After construction of a protein-protein interaction network, a total of 73 nodes and 99 edges were analyzed using MCODE, and three significant modules were selected...
June 14, 2018: Aging
Kenneth L Seldeen, Manhui Pang, Merced M Leiker, Jonathan E Bard, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Norma Nowak, Bruce R Troen
Vitamin D insufficiency (serum 25-OH vitamin D < 30 ng/ml) affects 70-80% of the general population, yet the long-term impacts on physical performance and the progression of sarcopenia are poorly understood. We therefore followed 6-month-old male C57BL/6J mice ( n =6) consuming either sufficient (STD, 1000 IU) or insufficient (LOW, 125 IU) vitamin D3/kg chow for 12 months (equivalent to 20-30 human years). LOW supplemented mice exhibited a rapid decline of serum 25-OH vitamin D levels by two weeks that remained between 11-15 ng/mL for all time points thereafter...
June 14, 2018: Aging
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