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Journals Annual Review of Analytical Ch...

Annual Review of Analytical Chemistry

https://read.qxmd.com/read/37018797/a-connected-world-system-level-support-through-biosensors
#21
REVIEW
Eric S McLamore, Shoumen P A Datta
The goal of protecting the health of future generations is a blueprint for future biosensor design. Systems-level decision support requires that biosensors provide meaningful service to society. In this review, we summarize recent developments in cyber physical systems and biosensors connected with decision support. We identify key processes and practices that may guide the establishment of connections between user needs and biosensor engineering using an informatics approach. We call for data science and decision science to be formally connected with sensor science for understanding system complexity and realizing the ambition of biosensors-as-a-service...
April 5, 2023: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/37000959/enhancing-the-depth-of-analyses-with-next-generation-ion-mobility-experiments
#22
REVIEW
Benjamin P Zercher, Theresa A Gozzo, AnneClaire Wageman, Matthew F Bush
Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution and multidimensional IM to biomolecular analyses, encompassing the fields of glycomics, lipidomics, peptidomics, and proteomics...
March 31, 2023: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/36944233/advances-and-emerging-medical-applications-of-direct-mass-spectrometry-technologies-for-tissue-analysis
#23
REVIEW
Mary E King, Monica Lin, Meredith Spradlin, Livia S Eberlin
Offering superb speed, chemical specificity, and analytical sensitivity, direct mass spectrometry (MS) technologies are highly amenable for the molecular analysis of complex tissues to aid in disease characterization and help identify new diagnostic, prognostic, and predictive markers. By enabling detection of clinically actionable molecular profiles from tissues and cells, direct MS technologies have the potential to guide treatment decisions and transform sample analysis within clinical workflows. In this review, we highlight recent health-related developments and applications of direct MS technologies that exhibit tangible potential to accelerate clinical research and disease diagnosis, including oncological and neurodegenerative diseases and microbial infections...
March 21, 2023: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/36888989/wearable-microfluidics-for-continuous-assay
#24
REVIEW
Pei-Heng Lin, Hsin-Hua Nien, Bor-Ran Li
The development of wearable devices provides approaches for the realization of self-health care. Easily carried wearable devices allow individual health monitoring at any place whenever necessary. There are various interesting monitoring targets, including body motion, organ pressure, and biomarkers. An efficient use of space in one small device is a promising resolution to increase the functions of wearable devices. Through integration of a microfluidic system into wearable devices, embedding complicated structures in one design becomes possible and can enable multifunction analyses within a limited device volume...
March 8, 2023: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35696523/saliva-diagnostics
#25
REVIEW
Taichiro Nonaka, David T W Wong
Cancer remains one of the leading causes of death, and early detection of this disease is crucial for increasing survival rates. Although cancer can be diagnosed following tissue biopsy, the biopsy procedure is invasive; liquid biopsy provides an alternative that is more comfortable for the patient. While blood, urine, and cerebral spinal fluid can all be used as a source of liquid biopsy, saliva is an ideal source of body fluid that is readily available and easily collected in the most noninvasive manner. Characterization of salivary constituents in the disease setting provides critical data for understanding pathophysiology and the evaluation of diagnostic potential...
June 13, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35696522/oxygen-measurement-in-microdevices
#26
REVIEW
Samantha M Grist, Kevin L Bennewith, Karen C Cheung
Oxygen plays a fundamental role in respiration and metabolism, and quantifying oxygen levels is essential in many environmental, industrial, and research settings. Microdevices facilitate the study of dynamic, oxygen-dependent effects in real time. This review is organized around the key needs for oxygen measurement in microdevices, including integrability into microfabricated systems; sensor dynamic range and sensitivity; spatially resolved measurements to map oxygen over two- or three-dimensional regions of interest; and compatibility with multimodal and multianalyte measurements...
June 13, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35216531/overcoming-major-barriers-to-developing-successful-sensors-for-practical-applications-using-functional-nucleic-acids
#27
REVIEW
JingJing Zhang, Tian Lan, Yi Lu
For many years, numerous efforts have been focused on the development of sensitive, selective, and practical sensors for environmental monitoring, food safety, and medical diagnostic applications. However, the transition from innovative research to commercial success is relatively sparse. In this review, we identify four scientific barriers and one technical barrier to developing successful sensors for practical applications, including the lack of general methods to ( a ) generate receptors for a wide range of targets, ( b ) improve sensor selectivity to overcome interferences, ( c ) transduce the selective binding to different optical, electrochemical, and other signals, and ( d ) tune dynamic range to match thresholds of detection required for different targets; and the costly development of a new device...
June 13, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/36854209/label-free-electrochemical-methods-for-disease-detection
#28
REVIEW
Kira L Rahn, Umesha Peramune, Tianyi Zhang, Robbyn K Anand
Label-free electrochemical biosensing leverages the advantages of label-free techniques, low cost, and fewer user steps, with the sensitivity and portability of electrochemical analysis. In this review, we identify four label-free electrochemical biosensing mechanisms: ( a ) blocking the electrode surface, ( b ) allowing greater access to the electrode surface, ( c ) changing the intercalation or electrostatic affinity of a redox probe to a biorecognition unit, and ( d ) modulating ion or electron transport properties due to conformational and surface charge changes...
February 28, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/36854208/nondestructive-3d-pathology-with-light-sheet-fluorescence-microscopy-for-translational-research-and-clinical-assays
#29
REVIEW
Jonathan T C Liu, Adam K Glaser, Chetan Poudel, Joshua C Vaughan
In recent years, there has been a revived appreciation for the importance of spatial context and morphological phenotypes for both understanding disease progression and guiding treatment decisions. Compared with conventional 2D histopathology, which is the current gold standard of medical diagnostics, nondestructive 3D pathology offers researchers and clinicians the ability to visualize orders of magnitude more tissue within their natural volumetric context. This has been enabled by rapid advances in tissue-preparation methods, high-throughput 3D microscopy instrumentation, and computational tools for processing these massive feature-rich data sets...
February 28, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/36854207/enhanced-multiplexing-technology-for-proteomics
#30
REVIEW
Bailey L Bowser, Renã A S Robinson
The identification of thousands of proteins and their relative levels of expression has furthered understanding of biological processes and disease and stimulated new systems biology hypotheses. Quantitative proteomics workflows that rely on analytical assays such as mass spectrometry have facilitated high-throughput measurements of proteins partially due to multiplexing. Multiplexing allows proteome differences across multiple samples to be measured simultaneously, resulting in more accurate quantitation, increased statistical robustness, reduced analysis times, and lower experimental costs...
February 28, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35216530/technologies-for-frugal-and-sensitive-point-of-care-immunoassays
#31
REVIEW
David S Kinnamon, Jacob T Heggestad, Jason Liu, Ashutosh Chilkoti
Immunoassays are a powerful tool for sensitive and quantitative analysis of a wide range of biomolecular analytes in the clinic and in research laboratories. However, enzyme-linked immunosorbent assay (ELISA)-the gold-standard assay-requires significant user intervention, time, and clinical resources, making its deployment at the point-of-care (POC) impractical. Researchers have made great strides toward democratizing access to clinical quality immunoassays at the POC and at an affordable price. In this review, we first summarize the commercially available options that offer high performance, albeit at high cost...
February 25, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35216529/emerging-optical-microscopy-techniques-for-electrochemistry
#32
REVIEW
Jean-François Lemineur, Hui Wang, Wei Wang, Frédéric Kanoufi
An optical microscope is probably the most intuitive, simple, and commonly used instrument to observe objects and discuss behaviors through images. Although the idea of imaging electrochemical processes operando by optical microscopy was initiated 40 years ago, it was not until significant progress was made in the last two decades in advanced optical microscopy or plasmonics that it could become a mainstream electroanalytical strategy. This review illustrates the potential of different optical microscopies to visualize and quantify local electrochemical processes with unprecedented temporal and spatial resolution (below the diffraction limit), up to the single object level with subnanoparticle or single-molecule sensitivity...
February 25, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35324254/mass-spectrometry-measurements-of-neuropeptides-from-identification-to-quantitation
#33
REVIEW
Eduardo A De La Toba, Sara E Bell, Elena V Romanova, Jonathan V Sweedler
Neuropeptides (NPs), a unique class of neuronal signaling molecules, participate in a variety of physiological processes and diseases. Quantitative measurements of NPs provide valuable information regarding how these molecules are differentially regulated in a multitude of neurological, metabolic, and mental disorders. Mass spectrometry (MS) has evolved to become a powerful technique for measuring trace levels of NPs in complex biological tissues and individual cells using both targeted and exploratory approaches...
February 24, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35316608/label-free-super-resolution-imaging-techniques
#34
REVIEW
Ryan E Leighton, Ariel M Alperstein, Renee R Frontiera
Biological and material samples contain nanoscale heterogeneities that are unresolvable with conventional microscopy techniques. Super-resolution fluorescence methods can break the optical diffraction limit to observe these features, but they require samples to be fluorescently labeled. Over the past decade, progress has been made toward developing super-resolution techniques that do not require the use of labels. These label-free techniques span a variety of different approaches, including structured illumination, transient absorption, infrared absorption, and coherent Raman spectroscopies...
February 22, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35303775/analysis-of-mitochondria-by-single-organelle-resolution
#35
REVIEW
Angelika B Harbauer, Annika Schneider, Dirk Wohlleber
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within different cell populations of a tissue but also within the same cell. Dysfunction or altered function affects the organelle itself and may also lead to malignancies or undesirable cell death. To understand cellular function or dysfunction, it is therefore necessary to analyze cellular components at the single-organelle level...
February 18, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35300527/analytical-chemistry-throughout-this-solar-system
#36
REVIEW
Kenneth Marshall Seaton, Morgan Leigh Cable, Amanda Michelle Stockton
One of the greatest and most long-lived scientific pursuits of humankind has been to discover and study the planetary objects comprising our solar system. Information gained from solar system observations, via both remote sensing and in situ measurements, is inherently constrained by the analytical (often chemical) techniques we employ in these endeavors. The past 50 years of planetary science missions have resulted in immense discoveries within and beyond our solar system, enabled by state-of-the-art analytical chemical instrument suites on board these missions...
February 17, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35300526/developing-fret-networks-for-sensing
#37
REVIEW
W Russ Algar, Katherine D Krause
Förster resonance energy transfer (FRET) is a widely used fluorescence-based sensing mechanism. To date, most implementations of FRET sensors have relied on a discrete donor-acceptor pair for detection of each analytical target. FRET networks are an emerging concept in which target recognition perturbs a set of interconnected FRET pathways between multiple emitters. Here, we review the energy transfer topologies and scaffold materials for FRET networks, propose a general nomenclature, and qualitatively summarize the dynamics of the competitive, sequential, homoFRET, and heteroFRET pathways that constitute FRET networks...
February 17, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35300525/quantitative-stimulated-raman-scattering-microscopy-promises-and-pitfalls
#38
REVIEW
Bryce Manifold, Dan Fu
Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a powerful chemical imaging tool that shows promise in numerous biological and biomedical applications. The spectroscopic capability of SRS enables identification and tracking of specific molecules or classes of molecules, often without labeling. SRS microscopy also has the hallmark advantage of signal strength that is directly proportional to molecular concentration, allowing for in situ quantitative analysis of chemical composition of heterogeneous samples with submicron spatial resolution and subminute temporal resolution...
February 17, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35167323/surface-analysis-techniques-in-forensic-science-successes-challenges-and-opportunities-for-operational-deployment
#39
REVIEW
Melanie J Bailey, Marcel de Puit, Francesco Saverio Romolo
Surface analysis techniques have rapidly evolved in the last decade. Some of these are already routinely used in forensics, such as for the detection of gunshot residue or for glass analysis. Some surface analysis approaches are attractive for their portability to the crime scene. Others can be very helpful in forensic laboratories owing to their high spatial resolution, analyte coverage, speed, and specificity. Despite this, many proposed applications of the techniques have not yet led to operational deployment...
February 15, 2022: Annual Review of Analytical Chemistry
https://read.qxmd.com/read/35259914/probing-and-visualizing-interfacial-charge-at-surfaces-in-aqueous-solution
#40
REVIEW
Giada Caniglia, Gözde Tezcan, Gabriel N Meloni, Patrick R Unwin, Christine Kranz
Surface charge density and distribution play an important role in almost all interfacial processes, influencing, for example, adsorption, colloidal stability, functional material activity, electrochemical processes, corrosion, nanoparticle toxicity, and cellular processes such as signaling, absorption, and adhesion. Understanding the heterogeneity in, and distribution of, surface and interfacial charge is key to elucidating the mechanisms underlying reactivity, the stability of materials, and biophysical processes...
February 8, 2022: Annual Review of Analytical Chemistry
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