journal
MENU ▼
Read by QxMD icon Read
search

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

journal
https://www.readbyqxmd.com/read/27910243/recent-advances-in-aliphatic-polyesters-for-drug-delivery-applications
#1
REVIEW
Katherine E Washington, Ruvanthi N Kularatne, Vasanthy Karmegam, Michael C Biewer, Mihaela C Stefan
The use of aliphatic polyesters in drug delivery applications has been a field of significant interest spanning decades. Drug delivery strategies have made abundant use of polyesters in their structures owing to their biocompatibility and biodegradability. The properties afforded from these materials provide many avenues for the tunability of drug delivery systems to suit individual needs of diverse applications. Polyesters can be formed in several different ways, but the most prevalent is the ring-opening polymerization of cyclic esters...
December 1, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27863136/biological-and-environmental-surface-interactions-of-nanomaterials-characterization-modeling-and-prediction
#2
REVIEW
Ran Chen, Jim E Riviere
The understanding of nano-bio interactions is deemed essential in the design, application, and safe handling of nanomaterials. Proper characterization of the intrinsic physicochemical properties, including their size, surface charge, shape, and functionalization, is needed to consider the fate or impact of nanomaterials in biological and environmental systems. The characterizations of their interactions with surrounding chemical species are often hindered by the complexity of biological or environmental systems, and the drastically different surface physicochemical properties among a large population of nanomaterials...
November 8, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27860449/cerium-oxide-nanoparticles-in-neuroprotection-and-considerations-for-efficacy-and-safety
#3
REVIEW
Beverly A Rzigalinski, Charles S Carfagna, Marion Ehrich
Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection...
November 8, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27813323/tumor-targeted-nanotherapeutics-overcoming-treatment-barriers-for-glioblastoma
#4
REVIEW
Aniket S Wadajkar, Jimena G Dancy, David S Hersh, Pavlos Anastasiadis, Nhan L Tran, Graeme F Woodworth, Jeffrey A Winkles, Anthony J Kim
Glioblastoma (GBM) is a highly aggressive and lethal form of primary brain cancer. Numerous barriers exist to the effective treatment of GBM including the tightly controlled interface between the bloodstream and central nervous system termed the 'neurovascular unit,' a narrow and tortuous tumor extracellular space containing a dense meshwork of proteins and glycosaminoglycans, and genomic heterogeneity and instability. A major goal of GBM therapy is achieving sustained drug delivery to glioma cells while minimizing toxicity to adjacent neurons and glia...
November 4, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27813275/complex-coacervate-based-materials-for-biomedicine
#5
REVIEW
Whitney C Blocher, Sarah L Perry
There has been increasing interest in complex coacervates for deriving and transporting biomaterials. Complex coacervates are a dense, polyelectrolyte-rich liquid that results from the electrostatic complexation of oppositely charged macroions. Coacervates have long been used as a strategy for encapsulation, particularly in food and personal care products. More recent efforts have focused on the utility of this class of materials for the encapsulation of small molecules, proteins, RNA, DNA, and other biomaterials for applications ranging from sensing to biomedicine...
November 4, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27813271/beyond-quantification-in-situ-analysis-of-transcriptome-and-pre-mrna-alternative-splicing-at-the-nanoscale
#6
REVIEW
Yi Cui, Jing Liu, Joseph Irudayaraj
In situ analysis offers a venue for dissecting the complex transcriptome in its natural context to tap into cellular processes that could explain the phenotypic physiology and pathology yet to be understood. Over the past decades, enormous progress has been made to improve the resolution, sensitivity, and specificity of single-cell technologies. The continued efforts in RNA research not only facilitates mechanistic studies of molecular biology but also provides state-of-the-art strategies for diagnostic purposes...
November 4, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27800665/status-and-trends-in-the-development-of-clinical-diagnostic-agents
#7
REVIEW
Tatjana Opacic, Vera Paefgen, Twan Lammers, Fabian Kiessling
Contrast agents (CA) are routinely used in clinical practice to improve the diagnosis of diseases and to monitor therapy response. The majority of CA comprises small molecules accumulating at pathological sites due to vascular abnormalities, such as changes in perfusion and permeability. For many diseases, high diagnostic accuracy can be achieved with contrast-enhanced imaging. This means that new CA will only succeed in translation if they either show superior performance with respect to diagnostic accuracy, safety and cost, support a new imaging modality, or are directly linked to the refinement of therapy, e...
October 31, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27800663/advances-in-the-development-of-aptamer-drug-conjugates-for-targeted-drug-delivery
#8
REVIEW
Ke Chen, Bo Liu, Bo Yu, Wen Zhong, Yi Lu, Jiani Zhang, Jie Liao, Jun Liu, Ying Pu, Liping Qiu, Liqin Zhang, Huixia Liu, Weihong Tan
A key goal of modern medicine is target-specific therapeutic intervention. However, most drugs lack selectivity, resulting in 'off-target' side effects. To address the requirements of 'targeted therapy,' aptamers, which are artificial oligonucleotides, have been used as novel targeting ligands to construct aptamer drug conjugates (ApDC) that can specifically bind to a broad spectrum of targets, including diseased cells. Accordingly, the application of aptamers in targeted drug delivery has attracted broad interest due to their impressive selectivity and affinity, low immunogenicity, easy synthesis with high reproducibility, facile modification, and relatively rapid tissue penetration with no toxicity...
October 31, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27791335/functional-carbon-nanodots-for-multiscale-imaging-and-therapy
#9
REVIEW
Fatemeh Ostadhossein, Dipanjan Pan
As an emerging class of carbon nanomaterials, carbon dots (CDs) have garnered many researchers' interests in the past decade due to their excellent biocompatibility, replete surface functional groups, water dispersibility, and unique photoluminescence. These extraordinary properties have opened new avenues for their advanced application in cell labeling, bioimaging, drug delivery, sensors, and energy-related devices. In this paper, we critically review recent advances in the synthetic strategies and the application of CDs for biological purposes, specifically, imaging and therapy...
October 28, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27781398/graphene-oxide-as-a-scaffold-for-bone-regeneration
#10
REVIEW
Brian D Holt, Zoe M Wright, Anne M Arnold, Stefanie A Sydlik
Graphene oxide (GO), the oxidized form of graphene, holds great potential as a component of biomedical devices, deriving utility from its ability to support a broad range of chemical functionalities and its exceptional mechanical, electronic, and thermal properties. GO composites can be tuned chemically to be biomimetic, and mechanically to be stiff yet strong. These unique properties make GO-based materials promising candidates as a scaffold for bone regeneration. However, questions still exist as to the compatibility and long-term toxicity of nanocarbon materials...
October 26, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27597649/%C3%AE-helical-coiled-coil-peptide-materials-for-biomedical-applications
#11
Yaoying Wu, Joel H Collier
Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these...
September 6, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27595635/recent-advances-of-using-polyhydroxyalkanoate-based-nanovehicles-as-therapeutic-delivery-carriers
#12
Zibiao Li, Xian Jun Loh
Polyhydroxyalkanoates (PHAs) are a class of diverse biodegradable polyesters that can be produced either by natural bioconversion process or by chemical synthesis via the ring-opening polymerization of β-lactones. Because of the excellent biodegradability and biocompatibility, the development of PHA-based nanovehicles as therapeutic delivery carriers, including nanoparticles, micelles, liposomes, and vesicles, has received considerable attention in recent years, and these sophisticated materials have demonstrated significant impact on the drug bioavailability, better encapsulation, and less toxic properties of biodegradable polymers...
September 6, 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27194461/vascular-targeted-nanocarriers-design-considerations-and-strategies-for-successful-treatment-of-atherosclerosis-and-other-vascular-diseases
#13
REVIEW
William J Kelley, Hanieh Safari, Genesis Lopez-Cazares, Omolola Eniola-Adefeso
Vascular-targeted nanocarriers are an attractive option for the treatment of a number of cardiovascular diseases, as they allow for more specific delivery and increased efficacy of many small molecule drugs. However, immune clearance, limited cellular uptake, and particle-cell dynamics in blood flow can hinder nanocarrier efficacy in many applications. This review aims to investigate successful strategies for the use of vascular-targeted nanocarriers in the treatment of cardiovascular diseases such as atherosclerosis...
November 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27040463/functional-nanoparticles-for-magnetic-resonance-imaging
#14
REVIEW
Xinpei Mao, Jiadi Xu, Honggang Cui
Nanoparticle-based magnetic resonance imaging (MRI) contrast agents have received much attention over the past decade. By virtue of a high payload of magnetic moieties, enhanced accumulation at disease sites, and a large surface area for additional modification with targeting ligands, nanoparticle-based contrast agents offer promising new platforms to further enhance the high resolution and sensitivity of MRI for various biomedical applications. T 2 * superparamagnetic iron oxide nanoparticles (SPIONs) first demonstrated superior improvement on MRI sensitivity...
November 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27038329/modifying-the-tumor-microenvironment-using-nanoparticle-therapeutics
#15
REVIEW
Aniruddha Roy, Shyh-Dar Li
Treatment of cancer has come a long way from the initial 'radical surgeries' to the multimodality treatments. For the major part of the last century, cancer was considered as a monocellular disorder, and treatment strategies were designed according to that hypothesis. However, the mortality rate from cancer continued to be high and a comprehensive treatment remained elusive. Recent progress in research has demonstrated that tumors are a complex network of neoplastic and non-neoplastic cells. The non-neoplastic cells, which are collectively called stroma, assist in tumor survival and progression...
November 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27016134/polymeric-nanoparticles-in-development-for-treatment-of-pulmonary-infectious-diseases
#16
REVIEW
Young H Lim, Kristin M Tiemann, David A Hunstad, Mahmoud Elsabahy, Karen L Wooley
Serious lung infections, such as pneumonia, tuberculosis, and chronic obstructive cystic fibrosis-related bacterial diseases, are increasingly difficult to treat and can be life-threatening. Over the last decades, an array of therapeutics and/or diagnostics have been exploited for management of pulmonary infections, but the advent of drug-resistant bacteria and the adverse conditions experienced upon reaching the lung environment urge the development of more effective delivery vehicles. Nanotechnology is revolutionizing the approach to circumventing these barriers, enabling better management of pulmonary infectious diseases...
November 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/27006133/nanoparticles-and-radiotracers-advances-toward-radionanomedicine
#17
REVIEW
Edwin C Pratt, Travis M Shaffer, Jan Grimm
In this study, we cover the convergence of radiochemistry for imaging and therapy with advances in nanoparticle (NP) design for biomedical applications. We first explore NP properties relevant for therapy and theranostics and emphasize the need for biocompatibility. We then explore radionuclide-imaging modalities such as positron emission tomography (PET), single-photon emission computed tomography (SPECT), and Cerenkov luminescence (CL) with examples utilizing radiolabeled NP for imaging. PET and SPECT have served as diagnostic workhorses in the clinic, while preclinical NP design examples of multimodal imaging with radiotracers show promise in imaging and therapy...
November 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/26952315/structural-colors-from-natural-to-artificial-systems
#18
REVIEW
Yulan Fu, Cary A Tippets, Eugenii U Donev, Rene Lopez
Structural coloration has attracted great interest from scientists and engineers in recent years, owing to fascination with various brilliant examples displayed in nature as well as to promising applications of bio-inspired functional photonic structures and materials. Much research has been done to reveal and emulate the physical mechanisms that underlie the structural colors found in nature. In this article, we review the fundamental physics of many natural structural colors displayed by living organisms as well as their bio-inspired artificial counterparts, with emphasis on their connections, tunability strategies, and proposed applications, which aim to maximize the technological benefits one could derive from these photonic nanostructures...
September 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/26888041/development-and-regulation-of-exosome-based-therapy-products
#19
REVIEW
Elena V Batrakova, Myung Soo Kim
Recently, various innovative therapies involving the ex vivo manipulation and subsequent reintroduction of exosome-based therapeutics into humans have been developed and validated, although no exosome-based therapeutics have yet to be brought into the clinic. Exosomes are nanosized vesicles secreted by many cells that utilize them for cell-to-cell communications to facilitate transport of proteins and genetic material. Comprised of cellular membranes with multiple adhesive proteins on their surface, exosomes offer distinct advantages that exceptionally position them as highly effective drug carriers...
September 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/26848106/coaxial-electrospun-fibers-applications-in-drug-delivery-and-tissue-engineering
#20
REVIEW
Yang Lu, Jiangnan Huang, Guoqiang Yu, Romel Cardenas, Suying Wei, Evan K Wujcik, Zhanhu Guo
Coelectrospinning and emulsion electrospinning are two main methods for preparing core-sheath electrospun nanofibers in a cost-effective and efficient manner. Here, physical phenomena and the effects of solution and processing parameters on the coaxial fibers are introduced. Coaxial fibers with specific drugs encapsulated in the core can exhibit a sustained and controlled release. Their exhibited high surface area and three-dimensional nanofibrous network allows the electrospun fibers to resemble native extracellular matrices...
September 2016: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
journal
journal
42419
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"