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Beneficial Microbes

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https://www.readbyqxmd.com/read/28299945/in-vitro-and-in-vivo-cholesterol-lowering-ability-of-lactobacillus-pentosus-kf923750
#1
F Bendali, K Kerdouche, S Hamma-Faradji, D Drider
Lactobacillus pentosus KF923750 was characterised for probiotic related properties and then characterised for cholesterol uptake in vitro as well as in vivo using rabbits fed a high-cholesterol diet. The survival percentage of L. pentosus KF923750 was 100% at pH 3, 52.18% at pH 2 and 36.21% at pH 2 plus pepsin. Similarly, this strain appeared resistant to bile (0.1% [98.42%], 0.3% [88.52%], 0.5% [75.60%] and 1% [71.15%]), after 4 h exposure. Moreover, L. pentosus KF923750 controlled growth of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 through the production of a bacteriocin-like inhibitory substance and anti-adhesive capabilities...
March 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28299944/streptococcus-thermophilus-fermented-milk-reduces-serum-mda-ldl-and-blood-pressure-in-healthy-and-mildly-hypercholesterolaemic-adults
#2
M Ito, S Kusuhara, W Yokoi, T Sato, H Ishiki, S Miida, A Matsui, K Nakamori, C Nonaka, K Miyazaki
Low-density lipoprotein (LDL)-cholesterol, malondialdehyde-modified low-density lipoprotein (MDA-LDL), MDA-LDL/LDL-cholesterol in serum, and blood pressure are considered useful risk markers of cardiovascular diseases. This study aimed to examine whether a fermented milk containing Streptococcus thermophilus YIT 2001 (ST), which has high anti-oxidative activity, would benefit healthy and mildly hyper-LDL-cholesterolaemic adults via a randomised, double-blind, placebo-controlled trial. ST-fermented milk or non-fermented placebo milk (PC) was consumed once a day for 12 weeks by 29 and 30 subjects, respectively, with average serum LDL-cholesterol levels of about 140 mg/dl...
March 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28116930/preparation-and-preservation-of-viable-akkermansia-muciniphila-cells-for-therapeutic-interventions
#3
J P Ouwerkerk, S Aalvink, C Belzer, W M De Vos
The anaerobic gut bacterium Akkermansia muciniphila is a well-characterised member of the mucosal microbiota and has shown to be a gut symbiont in human. A. muciniphila has been negatively associated with obesity and its associated metabolic disorders in various human cohorts while treatment with A. muciniphila cells reversed highfat diet-induced obesity and its associated metabolic disorders in mouse models. Therefore, administration of A. muciniphila has been suggested as a possible new therapeutic treatment for these omnipresent diseases...
January 24, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28116929/evaluation-of-colonisation-resistance-in-stool-of-human-donors-using-ex-vivo-in-vitro-and-in-vivo-assays
#4
M F Galvão, R W Bastos, L B Acurcio, B B Nascimento, S H C Sandes, R M E Arantes, M R Souza, F S Martins, L Q Vieira, J R Nicoli
The indigenous microbiota is the population of microorganisms normally present on the surface and mucosa of an individual, where it performs essential health functions, including the colonisation resistance (CR) against pathogens. To identify the bacteria responsible and the mechanisms involved in the CR, the germ-free (GF) animal model has been used, because in vitro studies cannot always be extrapolated to what occurs in vivo. In this study, ex vivo antagonism assays against seven enteropathogenic bacteria using stools from 15 healthy human donors confirmed that the CR showed individual variation...
January 24, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28116928/assessment-of-the-synbiotic-properites-of-human-milk-oligosaccharides-and-bifidobacterium-longum-subsp-infantis-in-vitro-and-in-humanised-mice
#5
S Musilova, N Modrackova, P Hermanova, T Hudcovic, R Svejstil, V Rada, V Tejnecky, V Bunesova
The mode of delivery plays a crucial role in infant gastrointestinal tract colonisation, which in the case of caesarean section is characterised by the presence of clostridia and low bifidobacterial counts. Gut colonisation can be modified by probiotics, prebiotics or synbiotics. Human milk oligosaccharides (HMOs) are infant prebiotics that show a bifidogenic effect. Moreover, genome sequencing of Bifidobacterium longum subsp. infantis within the infant microbiome revealed adaptations for milk utilisation. This study aimed to evaluate the synbiotic effect of B...
January 24, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28042704/development-of-an-in-vitro-immunobiotic-evaluation-system-against-rotavirus-infection-in-bovine-intestinal-epitheliocytes
#6
H Kobayashi, P Kanmani, T Ishizuka, A Miyazaki, J Soma, L Albarracin, Y Suda, T Nochi, H Aso, N Iwabuchi, J-Z Xiao, T Saito, J Villena, H Kitazawa
The bovine intestinal epithelial cell line (BIE cells) expresses the Toll-like receptor (TLR)3 and is able to mount an antiviral immune response after the stimulation with poly(I:C). In the present study, we aimed to further characterise the antiviral defence mechanisms in BIE cells by evaluating the innate immune response triggered by rotavirus (RV) infection. In addition, we attempted to determine whether immunobiotic bifidobacteria are able to confer protection of BIE cells against RV infection by beneficially modulating the antiviral immune response...
January 2, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28168883/foreword-probiotics-and-prebiotics-important-dietary-components-for-health
#7
Koen Venema
No abstract text is available yet for this article.
February 7, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28008787/a-review-of-dose-responses-of-probiotics-in-human-studies
#8
A C Ouwehand
The probiotic definition requires the administration of an 'adequate amount' in order to obtain a health benefit. What that amount should be is not indicated. Here, an overview is given of studies that investigated the dose-response relation of probiotics in human interventions. Studies were divided in; meta-analyses, meta-analyses on specific probiotic strains, and studies testing two or more doses of a probiotic (combination) in the same study. Meta-analyses on the effect of probiotics on antibiotic associated diarrhoea (AAD) suggest a dose-response effect; for Clostridium difficile-associated diarrhoea on the other hand no dose-response was observed...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/28008786/a-probiotic-combination-attenuates-experimental-colitis-through-inhibition-of-innate-cytokine-production
#9
M S Kim, J S Byun, Y S Yoon, D Y Yum, M J Chung, J C Lee
Inflammatory bowel disease (IBD) is a severe immune cell-mediated syndrome characterised by extensive inflammatory and effector mucosal responses leading to tissue destruction in the colon and small intestine. The leading hypothesis is that dysbiosis of the gut flora causes an excessive immune response and inflammation in the gastrointestinal track. Lactic acid bacteria (LAB) can correct dysbiosis of the normal microbiota. In the current study, the therapeutic potential of seven LAB strains in combination to treat IBD was evaluated using experimental colitis model...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/28008785/establishment-of-lactobacillus-plantarum-strain-in-honey-bee-digestive-tract-monitored-using-gfp-fluorescence
#10
P Javorský, L Kolesár Fecskeová, L Hrehová, R Sabo, J Legáth, P Pristas
Lactic acid bacteria are symbiotic bacteria that naturally reside in the gastrointestinal tract of honey bees. They serve a multitude of functions and are considered beneficial and completely harmless. In our experiments Lactobacillus plantarum strain B35, isolated from honey bee digestive tract, was modified using pAD43-25 plasmid carrying a functional GFP gene sequence (gfpmut3a) and used as a model for monitoring and optimisation of the mode of application. The establishment of this strain in honey bee digestive tract was monitored using GFP fluorescence...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/28008784/therapeutic-interventions-for-gut-dysbiosis-and-related-disorders-in-the-elderly-antibiotics-probiotics-or-faecal-microbiota-transplantation
#11
R C Vemuri, R Gundamaraju, T Shinde, R Eri
Ageing and physiological functions of the human body are inversely proportional to each other. The gut microbiota and host immune system co-evolve from infants to the elderly. Ageing is accompanied by a decline in gut microbial diversity, immunity and metabolism, which increases susceptibility to infections. Any compositional change in the gut is directly linked to gastrointestinal disorders, obesity and metabolic diseases. Increase in opportunistic pathogen invasion in the gut like Clostridium difficile leading to C...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/28008783/lactobacillus-rhamnosus-ncdc17-ameliorates-type-2-diabetes-by-improving-gut-function-oxidative-stress-and-inflammation-in-high-fat-diet-fed-and-streptozotocintreated-rats
#12
S Singh, R K Sharma, S Malhotra, R Pothuraju, U K Shandilya
Restoration of dysbiosed gut microbiota through probiotic may have profound effect on type 2 diabetes. In the present study, rats were fed high fat diet (HFD) for 3 weeks and injected with low dose streptozotocin to induce type 2 diabetes. Diabetic rats were then fed Lactobacillus rhamnosus NCDC 17 and L. rhamnosus GG with HFD for six weeks. L. rhamnosus NCDC 17 improved oral glucose tolerance test, biochemical parameters (fasting blood glucose, plasma insulin, glycosylated haemoglobin, free fatty acids, triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol), oxidative stress (thiobarbituric acid reactive substance and activities of catalase, superoxide dismutase and glutathione peroxidase in blood and liver), bifidobacteria and lactobacilli in cecum, expression of glucagon like peptide-1 producing genes in cecum, and adiponection in epididymal fat, while decreased propionate proportions (%) in caecum, and expression of tumour necrosis factor-α and interlukin-6 in epididymal fat of diabetic rats as compared to diabetes control group...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27936867/opportunities-for-probiotics-and-polyunsaturated-fatty-acids-to-improve-metabolic-health-of-overweight-pregnant-women
#13
K Mokkala, H Röytiö, U Ekblad, K Laitinen
Overweight during pregnancy predisposes both the mother and foetus to health complications. Maternal complications include gestational diabetes, obstetric problems and type 2 diabetes later in life. Complications for the offspring are not only restricted to the foetal period or birth, such as prematurity and foetal macrosomia, but may also have long-term metabolic health implications through the mechanism of early nutrition programming. One of the key metabolic components characterising overweight in the non-pregnant state is low-grade inflammation manifested by elevated levels of circulatory pro-inflammatory cytokines...
December 12, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27903093/challenges-in-simulating-the-human-gut-for-understanding-the-role-of-the-microbiota-in-obesity
#14
M Aguirre, K Venema
There is an elevated incidence of cases of obesity worldwide. Therefore, the development of strategies to tackle this condition is of vital importance. This review focuses on the necessity of optimising in vitro systems to model human colonic fermentation in obese subjects. This may allow to increase the resolution and the physiological relevance of the information obtained from this type of studies when evaluating the potential role that the human gut microbiota plays in obesity. In light of the parameters that are currently used for the in vitro simulation of the human gut (which are mostly based on information derived from healthy subjects) and the possible difference with an obese condition, we propose to revise and improve specific standard operating procedures...
December 1, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27903092/habitual-intake-of-fermented-milk-products-containing-lactobacillus-casei-strain-shirota-and-a-reduced-risk-of-hypertension-in-older-people
#15
Y Aoyagi, S Park, S Matsubara, Y Honda, R Amamoto, A Kushiro, K Miyazaki, R J Shephard
This study investigated relationships between the frequent intake of fermented milk products containing Lactobacillus casei strain Shirota (LcS) and the onset of hypertension (resting systemic pressure ≥140 mmHg [systolic]/≥90 mmHg [diastolic], a doctor's diagnosis and/or antihypertensive medicine use) during a 5-year period in 352 communityliving Japanese aged 65 to 93 years (125 men and 227 women). Initially normotensive subjects were divided into two groups (n=254 and n=98) on the basis of their intake of fermented milk products (<3 or ≥3 times/week, respectively), as estimated during an interview by a certified nutritionist...
December 1, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27903091/quantification-of-fitc-labelled-probiotic-lactobacillus-salivarius-dspv-001p-during-gastrointestinal-transit-in-broilers
#16
J E Blajman, D M Astesana, J A Zimmermann, E Rossler, A Romero Scharpen, A P Berisvil, M V Zbrun, L P Soto, M R Rosmini, L S Frizzo
The knowledge related to the fate of probiotics in the complex environment of the intestinal microbiota in broilers is just beginning to be elucidated; however, it is not yet well understood. A good method to investigate the mechanisms by which probiotics mediate their effects is to mark probiotic bacteria and trace them. The aim of this research was to develop a new method to estimate in vivo fluorescein isothiocyanate (FITC)-labelled Lactobacillus salivarius DSPV 001P counts during passage through the gastrointestinal tract (GIT) of broilers...
December 1, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27903090/pediococcus-acidilactici-lab4-and-lactobacillus-plantarum-lab12-assimilate-cholesterol-and-modulate-abca1-cd36-npc1l1-and-scarb1-in-vitro
#17
F T Lim, S M Lim, K Ramasamy
There is growing interest in the use of probiotic lactic acid bacteria (LAB) for prevention of hypercholesterolaemia. This study assessed the cholesterol lowering ability of Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in growth media. Both LAB yielded >98% (39.2 μg/ml) cholesterol lowering in growth media. Nile Red staining indicated direct assimilation of cholesterol by the LAB. The LAB were then explored for their prophylactic (pre-treatment of HT29 cells with LAB prior to cholesterol exposure) and biotherapeutic (treatment of HT29 cells with LAB after exposure to cholesterol) use against short and prolonged exposure of HT29 cells to cholesterol, respectively...
December 1, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27892710/oxytocin-a-missing-link-of-the-gut-brain-axis-between-probiotics-and-chronic-migraine-comment-on-the-effects-of-the-multispecies-probiotic-mixture-ecologic-%C3%A2-barrier-on-migraine-results-of-an-open-label-pilot-study
#18
https://www.readbyqxmd.com/read/27892709/gut-borne-saccharomyces-cerevisiae-a-promising-candidate-for-the-formulation-of-feed-additives-modulates-immune-system-and-gut-microbiota
#19
G García, C Dogi, A de Moreno de LeBlanc, C Greco, L Cavaglieri
The aim was to evaluate the effect of Saccharomyces cerevisiae RC016 on immune parameters and gut microbiota in healthy mice. Animals received S. cerevisiae RC016 for 10 days. Microbial translocation to liver and changes in some bacterial populations in caecum were determined. Immune stimulation was assessed at gut level (measure ofimmunoglobulin A (IgA)(+) cells and luminal cytokine profile) and by evaluating the activity of peritoneal macrophages. Oral administration of S. cerevisiae RC016 did not induce microbial translocation to liver...
November 30, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27824278/modulation-of-porcine-intestinal-epitheliocytes-immunetranscriptome-response-by-lactobacillus-jensenii-tl2937
#20
H Kobayashi, L Albarracin, N Sato, P Kanmani, A K M H Kober, W Ikeda-Ohtsubo, Y Suda, T Nochi, H Aso, S Makino, H Kano, S Ohkawara, T Saito, J Villena, H Kitazawa
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells). Here, transcriptomic studies using PIE cells were performed considering that this information would be valuable for understanding the mechanisms involved in the protective activity of the immunobiotic strain Lactobacillus jensenii TL2937 against intestinal inflammatory damage in pigs. In addition, those studies would provide criteria for selecting biomarkers for the screening of new immunobiotic strains...
November 30, 2016: Beneficial Microbes
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