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Beneficial Microbes

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https://www.readbyqxmd.com/read/28618865/streptococcus-thermophilus-ncimb-41856-ameliorates-signs-of-colitis-in-an-animal-model-of-inflammatory-bowel-disease
#1
J R Bailey, V Vince, N A Williams, T A Cogan
Treatment of inflammatory bowel disease (IBD) is mainly based on suppression of symptoms, often with numerous side effects. Trials of probiotics in IBD have frequently produced disappointing results. The majority of probiotics are unusual, since they do not require iron for growth, unlike many bacteria resident in the intestine. The IBD intestine is iron-rich due to bleeding and use of oral iron supplements; conventional probiotics would be rapidly outcompeted. We have evaluated an iron-responsive Streptococcus thermophilus strain for its potential to reduce signs of colitis...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618864/gut-microbiota-composition-strongly-correlates-to-peripheral-insulin-sensitivity-in-obese-men-but-not-in-women
#2
J Most, G H Goossens, D Reijnders, E E Canfora, J Penders, E E Blaak
Gut microbiota composition may play an important role in the development of obesity-related comorbidities. However, only few studies have investigated gender-differences in microbiota composition and gender-specific associations between microbiota or microbial products and insulin sensitivity. Insulin sensitivity (hyperinsulinemic-euglycemic clamp), body composition (dual energy X-ray absorptiometry), substrate oxidation (indirect calorimetry), systemic inflammatory markers and microbiota composition (PCR) were determined in male (n=15) and female (n=14) overweight and obese subjects...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618863/interaction-of-vaginal-lactobacillus-strains-with-hela-cells-plasma-membrane
#3
N Calonghi, C Parolin, G Sartor, L Verardi, B Giordani, G Frisco, A Marangoni, B Vitali
Vaginal lactobacilli offer protection against recurrent urinary and vaginal infections. The precise mechanisms underlying the interaction between lactobacilli and the host epithelium remain poorly understood at the molecular level. Deciphering such events can provide valuable information on the mode of action of commensal and probiotic bacteria in the vaginal environment. We investigated the effects exerted by five Lactobacillus strains of vaginal origin (Lactobacillus crispatus BC1 and BC2, Lactobacillus gasseri BC9 and BC11 and Lactobacillus vaginalis BC15) on the physical properties of the plasma membrane in a cervical cell line (HeLa)...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618862/probiotic-guidelines-and-physician-practice-a-cross-sectional-survey-and-overview-of-the-literature
#4
K Draper, C Ley, J Parsonnet
Probiotic use by patients and physicians has dramatically increased over the last decade, although definitive evidence is often lacking for their use. We examined probiotic-prescribing practices among health care providers (HCP) at a tertiary medical centre and compared these practices to clinical guidelines. HCP at the Stanford Medical Center received a survey on probiotic prescribing practices including choice of probiotic and primary indications. A broad overview of the literature was performed. Among 2,331 HCP surveyed, 632 responded...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618861/potentially-probiotic-lactobacillus-strains-with-anti-proliferative-activity-induce-cytokine-chemokine-production-and-neutrophil-recruitment-in-mice
#5
G Saxami, A Karapetsas, P Chondrou, S Vasiliadis, E Lamprianidou, I Kotsianidis, P Ypsilantis, S Botaitis, C Simopoulos, A Galanis
Lactobacillus pentosus B281 and Lactobacillus plantarum B282 are two Lactobacillus strains previously isolated from fermented table olives. Both strains were found to possess probiotic properties and displayed desirable technological characteristics for application as starters in novel functional food production. In the present study the anti-proliferative and immunostimulatory activities of the two strains were investigated. Firstly, we demonstrated that live L. pentosus B281 and L. plantarum B282 significantly inhibited the growth of human colon cancer cells (Caco-2) in a time- and dose-dependent manner...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28618860/the-effects-of-the-lactobacillus-casei-strain-on-obesity-in-children-a-pilot-study
#6
S Nagata, Y Chiba, C Wang, Y Yamashiro
There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28555502/safety-and-tolerance-of-three-probiotic-strains-in-healthy-infants-a-multi-centre-randomized-double-blind-placebo-controlled-trial
#7
S Manzano, J De Andrés, I Castro, J M Rodríguez, E Jiménez, I Espinosa-Martos
Some strains of species belonging to the genera Bifidobacterium and Lactobacillus are used in order to maintain health. Although these organisms have a long record of safe use, it is important to assess their safety and tolerance in potentially vulnerable populations, such as infants. The objective of this study was to evaluate the safety and tolerance of three probiotic strains (Bifidobacterium longum subsp. infantis R0033, Bifidobacterium bifidum R0071 and Lactobacillus helveticus R0052) in healthy infants aged 3 to 12 months...
May 30, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28555501/genomic-diversity-and-immunomodulatory-activity-of-lactobacillus-plantarum-isolated-from-dairy-products
#8
M Zago, E Scaltriti, B Bonvini, M E Fornasari, G Penna, L Massimiliano, D Carminati, M Rescigno, G Giraffa
In this study, we aimed to investigate some functional characteristics and the immunomodulatory properties of three strains of Lactobacillus plantarum of dairy origin which, in a previous screening, showed to be candidate probiotics. Genome sequencing and comparative genomics, which confirmed the presence of genes involved in folate and riboflavin production and in the immune response of dendritic cells (DCs), prompted us to investigate the ability of the three strains to accumulate the two vitamins and their immunomodulation properties...
May 30, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504581/bacillus-coagulans-gbi-30-6086-increases-plant-protein-digestion-in-a-dynamic-computer-controlled-in-vitro-model-of-the-small-intestine-tim-1
#9
D Keller, R Van Dinter, H Cash, S Farmer, K Venema
The aim of this study was to assess the potential of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC(30)] (BC30) to aid in protein digestion of alimentary plant proteins. To test this, three plant proteins, from pea, soy and rice, were digested in a validated in vitro model of the stomach and small intestine (TIM-1) in the absence and in the presence of BC30. Samples were taken from the TIM-1 fractions that mimic uptake of amino acids by the host and analysed for α-amino nitrogen (AAN) and total nitrogen (TN)...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504579/exopolysaccharide-producing-streptococcus-thermophilus-crl1190-reduces-the-inflammatory-response-caused-by-helicobacter-pylori
#10
G Marcial, J Villena, G Faller, A Hensel, G Font de Valdéz
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504578/effects-of-dietary-chitosan-on-growth-lipid-metabolism-immune-response-and-antioxidant-related-gene-expression-in-misgurnus-anguillicaudatus
#11
J Yan, C Guo, M A O Dawood, J Gao
This study was performed to evaluate the effects of dietary chitosan supplementation on growth performance, lipid metabolism, gut microbial, antioxidant status and immune responses of juvenile loach (Misgurnus anguillicaudatus). Five experimental diets were formulated to contain graded levels of chitosan (0 (control), 0.5, 1, 2 and 5% CHI) for 50 days. Results of the present study showed that body weight gain was significantly higher in fish fed chitosan supplemented diets in dose dependent manner than control group...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504577/lactobacillus-fermentum-im12-attenuates-inflammation-in-mice-by-inhibiting-nf-%C3%AE%C2%BAb-stat3-signalling-pathway
#12
S-M Lim, H M Jang, S-E Jang, M J Han, D-H Kim
In the present study, we isolated Lactobacillus fermentum IM12 from human gut microbiota, which strongly inhibited interleukin (IL)-6 expression and STAT3 activation in lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages, and examined its anti-inflammatory effect in mice with carrageenan-induced hind-paw oedema (CIE) or 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis (TIC). Oral administration of IM12 (0.2×10(9), 1×10(9) or 5×10(9) cfu/mouse, once a day for 3 days) in mice with CIE significantly suppressed the increase of oedema volume and thickness, as well as myeloperoxidase activity and IL-6, IL-17, NO, and prostaglandin E2 levels in the carrageenan-stimulated paw...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504576/is-the-role-of-human-female-reproductive-tract-microbiota-underestimated
#13
D Kamińska, M Gajecka
An issue that is currently undergoing extensive study is the influence of human vaginal microbiota (VMB) on the health status of women and their neonates. Healthy women are mainly colonised with lactobacilli such as Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus iners; however, other bacteria may be elements of the VMB, particularly in women with bacterial vaginosis. The implementation of culture-independent molecular methods in VMB characterisation, especially next-generation sequencing, have provided new information regarding bacterial diversity in the vagina, revealing a large number of novel, fastidious, and/or uncultivated bacterial species...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504575/alleviation-of-enterotoxigenic-escherichia-coli-challenge-by-recombinant-lactobacillus-plantarum-expressing-a-faeg-and-dc-targeting-peptide-fusion-protein
#14
G Yang, Y Jiang, P Tong, C Li, W Yang, J Hu, L Ye, W Gu, C Shi, B Shan, C Wang
FaeG is the major subunit of K88 fimbriae. These cell surface attachments are considered to be the major virulence factor of enterotoxigenic Escherichia coli (ETEC), which causes diarrhoea in piglets. The use of dendritic cell-targeting peptide (DCpep) has been demonstrated to be an effective approach to enhance the immunity of vaccines. Lactobacillus plantarum is an attractive candidate for oral vaccination owing to its beneficial effects and safety. In this study, L. plantarum was employed to deliver a FaeG-DCpep fusion antigen, and the immune response in mice was evaluated...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504568/lactobacillus-rhamnosus-crl1505-nasal-administration-improves-recovery-of-t-cell-mediated-immunity-against-pneumococcal-infection-in-malnourished-mice
#15
N Barbieri, M Herrera, S Salva, J Villena, S Alvarez
Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, resulted in diminished susceptibility to the challenge with the respiratory pathogen Streptococcus pneumoniae. Considering the known alterations induced by malnutrition on T lymphocytes and the importance of this cell population on the protection against respiratory pathogens, we aimed to study the effect of L...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504567/effects-of-lactobacillus-casei-ccfm419-on-insulin-resistance-and-gut-microbiota-in-type-2-diabetic-mice
#16
X Li, E Wang, B Yin, D Fang, P Chen, G Wang, J Zhao, H Zhang, W Chen
The antidiabetic effect of Lactobacillus is increasingly recognized worldwide. In this research, the hypoglycemic activity of Lactobacillus casei CCFM419 was investigated in mice with high-fat and low-dose streptozotocin induced type 2 diabetes. Oral L. casei CCFM419 administration favourably regulated blood glucose balance, increased glucose tolerance and protected islets in the diabetic mice, accompanied by an improvement in lipid metabolism. The homeostasis model of insulin resistance, insulin level and insulin tolerance test and mRNA expression of PI3K/Akt signalling pathway indexes revealed that L...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28504566/influence-of-lactobacillus-reuteri-l26-biocenol%C3%A2-on-immune-response-against-porcine-circovirus-type-2-infection-in-germ-free-mice
#17
V Karaffová, T Csank, D Mudroňová, J Király, V Revajová, S Gancarčíková, R Nemcová, J Pistl, Š Vilček, M Levkut
Probiotic bacteria are frequently used for prevention of bacterial infections of the gastrointestinal tract, but there are only limited studies on their efficacy against viral gut infections in animals. The aim of this study was to investigate the effect of probiotic Lactobacillus reuteri L26 Biocenol(TM) on the innate and adaptive immune responses in germ-free Balb/c mice, experimentally infected by porcine circovirus type 2 (PCV2), which confers immunosuppressive effect. A total of 30 six-week-old female mice were divided into 3 groups and animals in experimental group LPCV (n=10) were inoculated with L...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28441886/differences-between-live-and-heat-killed-bifidobacteria-in-the-regulation-of-immune-function-and-the-intestinal-environment
#18
H Sugahara, R Yao, T Odamaki, J Z Xiao
Probiotics are live microorganisms that confer a health benefit on the host, such as improvement of the intestinal environment, modulation of immune function and energy metabolism. Heat-killed probiotic strains have also been known to exhibit some physiological functions; however, the differences between live and heat-killed probiotics have not been well elucidated. In this study, we investigated the differences between live and heat-killed Bifidobacterium breve M-16V, a probiotic strain, in the regulation of immune function, intestinal metabolism and intestinal gene expression of the host using gnotobiotic mouse model and omics approaches...
April 26, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28441885/lactobacillus-plantarum-l9-but-not-lactobacillus-acidophilus-la-reduces-tumour-necrosis-factor-induced-bacterial-translocation-in-caco-2-cells
#19
B Wang, J Chen, S Wang, X Zhao, G Lu, X Tang
Translocation of bacteria across the intestinal barrier is important in the pathogenesis of systemic sepsis and multiple organ dysfunction syndromes. Inflammatory cytokines increase paracellular permeability that allows increased luminal bacteria to translocate across mucosal epithelium and further deteriorate the gut barrier. In order to reduce this risk, the prophylactic use of probiotics has been recently addressed. In this paper, we investigate the protective role toward tumour necrosis factor (TNF)-α induced non-pathogenic Escherichia coli translocation across Caco-2 monolayers of Lactobacillus strains...
April 26, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28403650/a-new-contribution-to-the-history-of-probiotics
#20
G A Calatayud, J E Suárez
No abstract text is available yet for this article.
April 13, 2017: Beneficial Microbes
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