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Biopreservation and Biobanking

John G Day, Simon Tytor, Jenny Egardt, Monica Applegren, Cecilia Rad-Menéndez, Olga Chepurnova, Wim Vyverman, Anna Godhe
Modern genomic and metabolomic tools have provided the possibility of generating and interrogating large datasets that can provide answers to previously imponderable taxonomic, evolutionary, ecological, and physiological questions. However, the curatorial tools needed to provide and maintain the relevant biological resources on which new knowledge can be built have not kept pace with this meteoric rise in scientific capacity, its associated activity, or the huge increase in published science. The availability of biological material of guaranteed identity and quality in Biological Resource Centers is fundamental for scientific research, but it crucially depends on there being adequate preservation/maintenance methods that are capable of ensuring phenotypic, genotypic, and functional security of the biological material(s)...
November 29, 2016: Biopreservation and Biobanking
Mirella Ciaburri, Mariarosaria Napolitano, Elena Bravo
Worldwide, the sustainability of public health systems is challenged by the increasing number and cost of personalized therapies. Quality biological samples stored in biobanks are essential for the provision of appropriate health services and also act as a reservoir for the development of precision medicine and biotechnological innovation. Economic sustainability is a crucial factor in the maintenance of biobanking activities. Traditionally, management of biobanking is performed by health researchers and/or clinicians whose knowledge of economic issues is inadequate...
November 29, 2016: Biopreservation and Biobanking
Alison Parry-Jones, Monique Albert
No abstract text is available yet for this article.
November 21, 2016: Biopreservation and Biobanking
Kevin McCluskey
Formal living collections have unique characteristics that distinguish them from other types of biorepositories. Comprising diverse resources, microbe culture collections, crop and biodiversity plant germplasm collections, and animal germplasm repositories are commonly allied with specific research communities or stakeholder groups. Among living collections, microbial culture collections have very long and unique life histories, with some being older than 100 years. Regulatory, financial, and technical developments have impacted living collections in many ways...
November 21, 2016: Biopreservation and Biobanking
Tony Brown, Devon D Kelly, Suzanne Vercauteren, William H Wilson, Alexander Werner
As guest editors of this sustainability issue of Biopreservation and Biobanking focused on business planning, utilization, and marketing, we invited a number of experts from different sectors of the biobanking arena to provide their views on business planning issues. Each expert was asked to provide a brief background statement on their biobanks, to build a context to understand their answers to the sustainability questions. We hope that these insights and experiences can provide valuable considerations and ideas for other biobanks who wish to develop or refine their own business plans, measure their utilization rates, and work toward financial sustainability...
November 21, 2016: Biopreservation and Biobanking
Jim Vaught
No abstract text is available yet for this article.
November 21, 2016: Biopreservation and Biobanking
Marianne K Henderson, Kirstin Goldring, Daniel Simeon-Dubach
No abstract text is available yet for this article.
November 18, 2016: Biopreservation and Biobanking
Susan M Kelly, Luke T Wiehagen, Philip E Schumacher, Rajiv Dhir
This article discusses the evolution of the University of Pittsburgh (UPitt) Health Sciences Tissue Bank (HSTB) operation and how it has successfully positioned itself, manages to sustain its value, and remains viable in today's research landscape. We describe the various components of our biobanking operation, which are valued by our researchers, thus leading to sustainability for our biorepository. Operating within the infrastructure of a large academic university, we have access to the most cutting-edge database resources for collecting, tracking, and annotating thousands of specimens...
November 18, 2016: Biopreservation and Biobanking
Melissa VonDran, Jeffrey A Thomas, Michelle P Freund, Maggie Ritsick, Maureen Orr, Wendy E Kaye, Annette Bakker, Pamela Knight
No abstract text is available yet for this article.
November 15, 2016: Biopreservation and Biobanking
Stephanie Angel, Hagen von Briesen, Young-Joo Oh, Marko K Baller, Heiko Zimmermann, Anja Germann
Cryopreservation of biological materials such as cells, tissues, and organs is a prevailing topic of high importance. It is employed not only in many research fields but also in the clinical area. Cryopreservation is of great importance for reproductive medicine and clinical studies, as well as for the development of vaccines. Peripheral blood mononuclear cells (PBMCs) are commonly used in vaccine research where comparable and reliable results between different research institutions and laboratories are of high importance...
October 28, 2016: Biopreservation and Biobanking
Rebecca O Barnes, Katheryn E Shea, Peter H Watson
As health research increasingly relies on biospecimens and associated data, new demands have emerged for biorepositories to provide assurances of the quality of their overall operations, not just assurances of the quality of the biospecimens and data that they hold. The biobanking community has responded in various ways, including the creation of two different programs to disseminate biobanking best practices. This article describes in detail the Canadian Tissue Repository Network (CTRNet) Biobank Certification Program and the College of American Pathologists (CAP) Biorepository Accreditation Program...
October 14, 2016: Biopreservation and Biobanking
Rafael Calixto Bortolin, Juciano Gasparotto, Amanda Rodrigues de Vargas, Maurilio da Silva Morrone, Alice Kunzler, Bernardo Saldanha Henkin, Paloma Rodrigues Chaves, Sabrina Roncato, Daniel Pens Gelain, José Cláudio Fonseca Moreira
Most scientific studies are too long to be conducted in a single day or even in a few days. Thus, there is a need to store samples for subsequent investigations. There is sparse information about specific sample storage protocols that minimize analytical error and variability in evaluations of redox parameters. Therefore, the effects of storage temperature and freezing time on enzymatic activities, protein oxidative damage, and CAT (catalase) and SOD1 (superoxide dismutase) immunocontent of blood, liver, and brain from rats were determined for two different sample forms (frozen homogenized tissue or frozen intact tissue)...
September 23, 2016: Biopreservation and Biobanking
Wei Liang, Xuexun Zhou, Lan Yao, Baolin Liu
The preservation of DNA, RNA, and protein markers in biological specimens is essential for initial diagnosis, subsequent verification, and comparison, as well as for archival retention of pathological materials in modern molecular diagnostics and precision medicine. Considerable attention has been paid to the methods of collection, handling, and preparation of specimens for initial testing, but insufficient attention to the long-term specimen preservation for later verification, comparison, and archival retention...
September 12, 2016: Biopreservation and Biobanking
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Biopreservation and Biobanking
Marianna J Bledsoe, Marianne Henderson, Anne-Marie Tassé, Bartha M Knoppers
No abstract text is available yet for this article.
October 2016: Biopreservation and Biobanking
Jim Vaught
No abstract text is available yet for this article.
October 2016: Biopreservation and Biobanking
Lothar Lauterboeck, Debapriya Saha, Anamika Chatterjee, Nicola Hofmann, Birgit Glasmacher
In the previous decade, numerous biobanks were established and have created large markets for the storage of bioactive compounds, cells, and tissues for medical and diagnostic applications. For in vivo clinical and therapeutic purposes, it is critical to use well-defined and xeno-free components during cultivation, preservation, and transplantation of biological material. Safe and efficacious storage of bioactive molecules, cells, and tissues, without the addition of undefined medium components, minimizes risks of zoonotic disease transmission and is thus an essential and desirable prerequisite for biobanks...
September 7, 2016: Biopreservation and Biobanking
Lise Matzke, Sindy Babinszky, Alex Slotty, Anna Meredith, Tania Castillo-Pelayo, Marianne Henderson, Daniel Simeon-Dubach, Brent Schacter, Peter H Watson
The notion of attributing user fees to researchers for biospecimens provided by biobanks has been discussed frequently in the literature. However, the considerations around how to attribute the cost for these biospecimens and data have, until recently, not been well described. Common across most biobank disciplines are similar factors that influence user fees such as capital and operating costs, internal and external demand, and market competition. A biospecimen user fee calculator tool developed by CTRNet, a tumor biobank network, was published in 2014 and is accessible online at www...
August 30, 2016: Biopreservation and Biobanking
William E Grizzle, Dennis Otali, Katherine C Sexton, Daniel S Atherton
Frequently investigators request that tissues be collected and processed in less than one hour following removal from a patient. Some biorepositories expend significant personnel time and other resources in trying to meet such goals; however, it is unclear whether the perceived benefits of relatively short cold ischemia times warrant these added costs. The literature of human surgical tissues prospectively exposed to cold ischemia at several time points was reviewed to compare the changes in transcripts/genes and microRNA with time of cold ischemia...
August 23, 2016: Biopreservation and Biobanking
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