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Lower Urinary Tract Symptoms

Minoru Kobayashi, Akinori Nukui, Takao Kamai
OBJECTIVES: The objective of the present study was to evaluate comparative efficacy and tolerability of antimuscarinics and mirabegron as primary and salvage therapy in patients with overactive bladder (OAB). METHODS: Patients ≥50 years with OAB symptoms were enrolled. Patients were initially treated with antimuscrinics or mirabegron for 8 weeks. When patients were refractory or intolerant to an initial treatment, drugs were switched to the other. The initial and second-line efficacy was assessed at baseline, 4 and 8 weeks after the treatment having the following parameters of the International Prostatic Symptom Score (IPSS), quality of life (QOL) index, Overactive Bladder Symptom Score (OABSS) and post-void residual (PVR) urine volume...
December 23, 2016: Lower Urinary Tract Symptoms
Benjamin M Brucker, Lysanne Campeau, Eva Fong, Sidhartha Kalra, Nirit Rosenblum, Victor W Nitti
OBJECTIVES: The use of fluoroscopy during urodynamics can be helpful in the evaluation of patients with lower urinary tract dysfunction. However, fluoroscopy introduces the potential hazards of ionizing radiation, including malignancy. In this study we analyzed the data for radiation exposure during videourodynamic study (VUDS) at our center; we have also tried to establish the factors associated with increased exposure to radiation during VUDS. METHODS: We reviewed all VUDS from August 2010 to May 2011...
December 19, 2016: Lower Urinary Tract Symptoms
Gi H Seo, Sung R Shim, Hwan W Lee, Jin H Kim, Dong-Il Chun, Hyun J Kim, Hyun Y Lee, Jae H Kim
OBJECTIVE: The aim of this study is to evaluate the risk for hip fracture associated with adverse drug reactions caused by α1-adrenergic (alpha) blockers to treat female voiding dysfunction. METHODS: Information from the Health Insurance Review and Assessment Service database from January 1, 2008 to December 31, 2012 was used. Hip fracture women patients who received a prescription for an alpha blocker due to voiding dysfunction were the cases. A 30-day hazard period after administration of an alpha blocker was set...
December 19, 2016: Lower Urinary Tract Symptoms
Satoshi Washino, Masaru Hirai, Kimitoshi Saito, Yutaka Kobayashi, Yoshiaki Arai, Tomoaki Miyagawa
OBJECTIVE: To evaluate the impact of androgen deprivation therapy (ADT) on prostate volume, lower urinary tract symptoms (LUTS), and LUTS-related quality of life (QOL) in patients with prostate cancer. METHODS: Patients with prostate cancer (PCa) were treated with goserelin and bicalutamide for 24 weeks. Changes in the total prostate volume (TPV), International Prostate Symptom Score (IPSS), and QOL score for urinary symptoms were assessed every 12 weeks. Of the 42 patients enrolled, 8 patients withdrew and 2 were excluded, so 32 patients were analyzed...
December 12, 2016: Lower Urinary Tract Symptoms
Manami Kinjo, Yuki Sekiguchi, Yasukuni Yoshimura, Kikuo Nutahara
OBJECTIVES: To compare persistence with medication and the reasons for discontinuation of mirabegron or solifenacin therapy up to12 months in women with overactive bladder (OAB). METHODS: Female OAB patients who presented to women's urology clinics were enrolled in a prospective, randomized, two-arm study. Patients were randomized to receive mirabegron at 25-50 mg (n = 76) or solifenacin at 2.5-5 mg (n = 72). The persistence rate and the reasons for discontinuation were investigated up to 12 months...
December 2, 2016: Lower Urinary Tract Symptoms
Antonio Simone Laganà, Valentina Lucia LA Rosa, Agnese Maria Chiara Rapisarda, Salvatore Giovanni Vitale
No abstract text is available yet for this article.
November 25, 2016: Lower Urinary Tract Symptoms
Yumiko Nozawa, Daisuke Kato, Hiromi Tabuchi, Kentarou Kuroishi
OBJECTIVES: To provide real-world data on Japanese patients with overactive bladder (OAB) initiating treatment with the β3 -adrenoceptor agonist, mirabegron. This study examined prescribing patterns, adverse drug reaction (ADR) incidence, and treatment effectiveness. METHODS: Full medical histories, including prior/concomitant drug use, were collected before initiating mirabegron treatment. After 12 weeks mirabegron, physicians assessed ADR incidence and treatment effectiveness...
November 17, 2016: Lower Urinary Tract Symptoms
Shingo Iino, Masayuki Kaneko, Mamoru Narukawa
OBJECTIVES: To identify a potential primary endpoint in an early-phase exploratory trial among key overactive bladder (OAB) symptoms. METHODS: Placebo-controlled double-blinding trials in patients with OAB were extracted for systematic literature review. The correlation between key OAB symptoms recorded in bladder diaries and coefficient of variation (CV) in each study were assessed. RESULTS: Forty-one controlled trials were extracted for the present review...
October 28, 2016: Lower Urinary Tract Symptoms
Nobuyuki Mitsukawa, Yoshitaka Kubota, Shinsuke Akita, Masakazu Hasegawa, Atsuomi Saiga, Kaneshige Satoh
CASE: The patient was a 3-year-old with hypospadias. Urethroplasty was performed as a two-stage procedure, but a severe urethral stricture occurred due to a postoperative infection and the patient was virtually in urinary retention. An emergency cystostomy was performed, and thereafter urethral reconstruction was performed. A large urethral diverticulum had formed in the scrotum. The inner wall of the diverticulum was found to be completely epithelialized and well vascularized. Therefore, it was elevated as a skin flap and a neourethra was reconstructed up to the glans region using the diverticular tissue...
September 2016: Lower Urinary Tract Symptoms
Takahiko Mitsui, Yukiko Kanno, Takeya Kitta, Kimihiko Moriya, Katsuya Nonomura
OBJECTIVES: To investigate the effect of descending serotonergic and noradrenergic pathways on nociception in the lower urinary tract (LUT). METHODS: Female Sprague-Dawley rats were used. Following intraperitoneal administration of Vehicle or Milnacipran (30 mg/kg), which is one of serotonin-noradrenaline reuptake inhibitors (SNRI), 0.1% AA was infused into the bladder in normal (n = 4, each) and spinal cord injury (SCI) (n = 4, each) rats for 2 h on consciousness, and c-Fos, 5-HT and DβH were stained using immunohistochemistry at the L6 spinal cord as spinal areas associated with LUT...
September 2016: Lower Urinary Tract Symptoms
Young Hwii Ko, Chang-Hyun Song, Ji Woong Choi, Hee Chang Jung, Phil Hyun Song
OBJECTIVES: To evaluate the effect on sexual function of patients and their spouses after transobturator tape (TOT) procedure, prospectively. Midurethral sling procedure has been widely performed for treatment of urinary incontinence; however, little has been reported regarding sexual function after surgery. METHODS: Between September 2012 and June 2013, 65 patients undergoing TOT and their sexual partners were enrolled. An investigation was conducted using validated, self-administered questionnaires, Female Sexual Function Index (FSFI) and satisfaction domain on Male Sexual Health Questionnaire (MSHQ) for evaluation of couple's sexual function...
September 2016: Lower Urinary Tract Symptoms
Jan Krhut, Marcel Gärtner, Katarína Zvarová, Michael Desarno, Peter Zvara
OBJECTIVE: The goal of this study was to compare a novel wireless phone and web based technology to record and store overactive bladder symptoms (OAB-S) to a traditional pen and paper micturition chart. METHODS: Overactive bladder symptoms were recorded over a period of 3 days using both an electronic micturition chart (EMC) and the standard pen and paper micturition chart (MC). Twenty-nine men, with lower urinary tract symptoms (LUTS), were included in the study...
September 2016: Lower Urinary Tract Symptoms
Naoki Wada, Hiromichi Iuchi, Masafumi Kita, Kazumi Hashizume, Seiji Matsumoto, Hidehiro Kakizaki
OBJECTIVES: To investigate urodynamic efficacy and safety of mirabegron add-on treatment with tamsulosin for Japanese male patients with overactive bladder (OAB). METHODS: A prospective study was conducted in 26 consecutive male patients with OAB who had been taking tamsulosin. OAB was diagnosed by overactive bladder symptom score (OABSS). Before and 8 weeks after mirabegron add-on treatment with preceding tamsulosin, we assessed OABSS, International Prostate Symptom Score (IPSS), free uroflowmetry (UFM), filling cystometry and pressure-flow study (PFS)...
September 2016: Lower Urinary Tract Symptoms
HongJing Jiang, Yu Zhou
OBJECTIVE: The aim of the present study was to objectively evaluate the safety and efficacy of Thulium laser prostatectmy (TmLRP) versus transurethral resection of prostate (TURP) in treating benign prostate hyperplasia (BPH). METHODS: Online databases such as Cochrane Library, PubMed, Embase, and Chinese biomedicine literature database were searched by randomized control trial (RCT), quasi-randomized control trial (Q-RCT) and case control study (CCSs) about TmLRP versus TURP for the treatment of BPH...
September 2016: Lower Urinary Tract Symptoms
Wan Song, Tae Heon Kim, Jin Woo Chung, Won Jin Cho, Ha Na Lee, Young Suk Lee, Kyu-Sung Lee
OBJECTIVES: To evaluate anatomical and functional outcomes of the Prolift Transvaginal Mesh for treatment of pelvic organ prolapse (POP) with regard to safety and satisfaction. METHODS: We reviewed the medical records of 163 patients who underwent POP repair with Prolift Transvaginal Mesh between December 2005 and March 2012. An "optimal" anatomic outcome was defined as Pelvic Organ Prolapse Quantification System (POP-Q) stage 0, and a "satisfactory" anatomic outcome was defined as POP-Q stage 1...
September 2016: Lower Urinary Tract Symptoms
Osamu Yamaguchi, Eiji Uchida, Naruhito Higo, Hidenao Minami, Shigeo Kobayashi, Hiroyuki Sato
OBJECTIVE: To evaluate the efficacy, safety, and optimum dose of once-daily oxybutynin patch for overactive bladder. METHODS: A randomized double-blind trial was conducted in patients with overactive bladder symptoms for ≥24 weeks, who received an oxybutynin patch (73.5 or 105 mg) or placebo once daily for 8 weeks. The primary endpoint was the change in the daily frequency of micturition from baseline to the end of study. RESULTS: A total of 579 patients were randomized to the placebo group (n = 164), 73...
September 2016: Lower Urinary Tract Symptoms
Edmond P H Choi, Cindy L K Lam, Weng Yee Chin
OBJECTIVES: Lower urinary tract symptoms (LUTS) can impact both mental health and health-related quality of life (HRQOL). To date, however, their associations with outcomes have only been examined in isolation and the interactive relationship between LUTS, mental health and HRQOL remains poorly understood. The aim of this study was to determine whether mental health mediates the relationship between LUTS severity and HRQOL. METHODS: Five hundred and nineteen primary care subjects with LUTS completed a structured questionnaire including the International Prostate Symptom Score (IPSS), the adapted Incontinence Impact Questionnaire-7 (IIQ-7), the Chinese (HK) SF-12 Health Survey Version 2 (SF-12 v2) and the Depression, Anxiety and Stress Scale-21 (DASS-21)...
September 2016: Lower Urinary Tract Symptoms
Sheng-Mou Hsiao, Ho-Hsiung Lin, Hann-Chorng Kuo
OBJECTIVES: Details on the therapeutic effects of long-term antimuscarinic therapy have not been reported. Thus, the aim of this study is to evaluate the detailed long-term therapeutic effect of antimuscarinic therapy. METHODS: All consecutive patients who visited the urologic outpatient clinics of a medical center for treatment of overactive bladder syndrome and received antimuscarinic therapy of 12 months or more were retrospectively reviewed. All medical records, including the Overactive Bladder Symptom score (OABSS), the modified Indevus Urgency Severity Scale and the International Prostate Symptoms score (IPSS) questionnaires, and uroflowmetry parameters were reviewed at each visit...
August 12, 2016: Lower Urinary Tract Symptoms
Christine Mpundu-Kaambwa, Billingsley Kaambwa, Sarah Appleton, Sean Martin, Gary Wittert, Robert Adams
OBJECTIVE: To determine the suitability of using the International Prostate Symptom Score (IPSS), a condition-specific instrument, within economic evaluation of lower urinary tract symptom (LUTS) interventions. METHODS: Data were obtained from a cohort of 2236 community-dwelling Australian men. Using correlations and a modified Bland-Altman plot, we investigated the convergent validity of the IPSS with two generic quality of life (GQol) instruments: the Assessment of Quality of Life 4 Dimensions (AQoL-4D) and the Short-Form 36 (SF-36)...
July 26, 2016: Lower Urinary Tract Symptoms
Sung Ryul Shim, Jae Heon Kim, Seung Whan Doo, Won Jae Yang, Eun Seop Song, Yun Seob Song
OBJECTIVES: To date, there is no overall agreement as to risk of ambient temperature for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Thus, we focused on ambient temperature as an environmental factor affecting LUTS and attempted to explain the temperature differences in LUTS severity in cases in real clinical practice. METHODS: This was a multicenter, cross-sectional survey. The study involved 1612 men aged 40 years and older who visited 23 university hospitals in 10 major areas in South Korea between September 2010 and December 2011...
July 20, 2016: Lower Urinary Tract Symptoms
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