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International Journal of Oral Science

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https://www.readbyqxmd.com/read/29777107/differentiation-of-periapical-granulomas-and-cysts-by-using-dental-mri-a-pilot-study
#1
Alexander Juerchott, Thorsten Pfefferle, Christa Flechtenmacher, Johannes Mente, Martin Bendszus, Sabine Heiland, Tim Hilgenfeld
The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging (MRI). Prior to apicoectomy, 11 patients with radiographically confirmed periapical lesions underwent dental MRI, including fat-saturated T2-weighted (T2wFS) images, non-contrast-enhanced T1-weighted images with and without fat saturation (T1w/T1wFS), and contrast-enhanced fat-saturated T1-weighted (T1wFS+C) images. Two independent observers performed structured image analysis of MRI datasets twice...
May 17, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29748557/recombinant-amelogenin-regulates-the-bioactivity-of-mouse-cementoblasts-in-vitro
#2
Sema S Hakki, S Buket Bozkurt, Emre Türkay, Michel Dard, Nuhan Purali, Werner Götz
Amelogenin (AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG (rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts (OCCM-30) were treated with different concentrations (0.1, 1, 10, 100, 1000, 10,000, 100,000 ng · mL-1 ) of recombinant human AMG (rhAMG) and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein (BSP), osteocalcin (OCN), collagen type I (COL I), osteopontin (OPN), runt-related transcription factor 2 (Runx2), cementum attachment protein (CAP), and alkaline phosphatase (ALP) genes using quantitative RT-PCR...
May 9, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29760467/the-oral-microbiome-bank-of-china
#3
Peng Xian, Zhou Xuedong, Xu Xin, Li Yuqing, Li Yan, Li Jiyao, Su Xiaoquan, Huang Shi, Xu Jian, Liao Ga
The human microbiome project (HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database (HOMD) was established in the US...
May 3, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29695713/autonomic-reinnervation-and-functional-regeneration-in-autologous-transplanted-submandibular-glands-in-patients-with-severe-keratoconjunctivitis-sicca
#4
Xueming Zhang, Ningyan Yang, Xiaojing Liu, Jiazeng Su, Xin Cong, Liling Wu, Yan Zhang, Guangyan Yu
Autologous submandibular gland (SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously. This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time...
April 25, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29686224/activation-of-%C3%AE-catenin-signaling-in-aggrecan-expressing-cells-in-temporomandibular-joint-causes-osteoarthritis-like-defects
#5
Tianqian Hui, Yachuan Zhou, Tingyu Wang, Jun Li, Shanxing Zhang, Lifan Liao, Jianhong Gu, Ling Ye, Lan Zhao, Di Chen
β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular joint (TMJ), we have generated β-catenin conditional activation mice (β-cat(ex3) Agc1CreER ) by breeding Agc1-CreER mice with β-cateninflox(ex3)/+ mice. Results of histologic analysis showed the progressive TMJ defects in 3- and 6-month-old β-cat(ex3) Agc1CreER mice (tamoxifen induction was performed at 2 weeks of age), including decreased chondrocyte numbers in the superficial layer associated with less Alcian blue staining, increased numbers of hypertrophic chondrocytes in deep layers, and rough articular surface...
April 23, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29654284/activation-of-hypoxia-inducible-factor-1-attenuates-periapical-inflammation-and-bone-loss
#6
Kimito Hirai, Hisako Furusho, Kiichi Hirota, Hajime Sasaki
Hypoxia (low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1 (HIF-1). Hypoxia interferes degradation of HIF-1 alpha subunit (HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit (HIF-1β) and subsequent activation of HIF-1 pathway. Apical periodontitis (periapical lesion) is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone...
April 13, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29563493/accelerated-and-enhanced-osteointegration-of-mao-treated-implants-histological-and-histomorphometric-evaluation-in-a-rabbit-model
#7
Xin Li, Haiyang Xu, Baodong Zhao, Shuai Jiang
Microarc oxidation (MAO) has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface (SF) implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model, a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses...
March 22, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29555901/in-vivo-optical-imaging-in-head-and-neck-oncology-basic-principles-clinical-applications-and-future-directions
#8
Chenzhou Wu, John Gleysteen, Nutte Tarn Teraphongphom, Yi Li, Eben Rosenthal
Head and neck cancers become a severe threat to human's health nowadays and represent the sixth most common cancer worldwide. Surgery remains the first-line choice for head and neck cancer patients. Limited resectable tissue mass and complicated anatomy structures in the head and neck region put the surgeons in a dilemma between the extensive resection and a better quality of life for the patients. Early diagnosis and treatment of the pre-malignancies, as well as real-time in vivo detection of surgical margins during en bloc resection, could be leveraged to minimize the resection of normal tissues...
March 18, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29555898/erg3-and-erg11-genes-are-critical-for-the-pathogenesis-of-candida-albicans-during-the-oral-mucosal-infection
#9
Yujie Zhou, Min Liao, Chengguang Zhu, Yao Hu, Ting Tong, Xian Peng, Mingyun Li, Mingye Feng, Lei Cheng, Biao Ren, Xuedong Zhou
The hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form typical hyphae but failed to cause the oral mucosal infection in vitro and in vivo for the first time. In particular, the erg3Δ/Δ and erg11Δ/Δ strains co-cultured with epithelial cells significantly reduced the adhesion, damage, and cytokine (interleukin-1α (IL-1α)) production, whereas the invasion was not affected in vitro...
March 16, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29555907/orthodontic-tooth-separation-activates-the-hypothalamic-area-in-the-human-brain
#10
Yoshiko Ariji, Hisataka Kondo, Ken Miyazawa, Masako Tabuchi, Syuji Koyama, Yoshitaka Kise, Akifumi Togari, Shigemi Gotoh, Eiichiro Ariji
OBJECTIVES: An animal experiment clarified that insertion of an orthodontic apparatus activated the trigeminal neurons of the medulla oblongata. Orthodontic tooth movement is known to be associated with the sympathetic nervous system and controlled by the nucleus of the hypothalamus. However, the transmission of both has not been demonstrated in humans. The purpose of this study were to examine the activated cerebral areas using brain functional magnetic resonance imaging (MRI), when orthodontic tooth separators were inserted, and to confirm the possibility of the transmission route from the medulla oblongata to the hypothalamus...
March 15, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29540669/common-dental-diseases-in-children-and-malocclusion
#11
Jing Zou, Mingmei Meng, Clarice S Law, Yale Rao, Xuedong Zhou
Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition...
March 13, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29531334/effect-of-high-frequency-loading-and-parathyroid-hormone-administration-on-peri-implant-bone-healing-and-osseointegration
#12
Aya Shibamoto, Toru Ogawa, Joke Duyck, Katleen Vandamme, Ignace Naert, Keiichi Sasaki
The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats (n = 44) were divided into three groups: PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration (50 Hz at 0...
March 13, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29497061/influence-of-glass-based-dental-ceramic-type-and-thickness-with-identical-shade-on-the-light-transmittance-and-the-degree-of-conversion-of-resin-cement
#13
Soram Oh, Su-Mi Shin, Hyun-Jung Kim, Janghyun Paek, Sung-Joon Kim, Tai Hyun Yoon, Sun-Young Kim
The purpose of this study was to assess the influence of the types and thicknesses of glass ceramic plates on light transmittance and compare the degrees of conversion (DC) of resin cement under the ceramic materials. Three ceramic plates with thicknesses of 0.5, 1.0, 2.0, and 4.0 mm were fabricated from each of five commercial ceramic blocks in shade A2: high-translucency and low-translucency IPS Empress CAD (Emp_HT and Emp_LT); high-translucency and low-translucency IPS e.max CAD (Emx_HT and Emx_LT); and Vita Mark II (Vita)...
March 2, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29491357/ectomesenchymal-chondromyxoid-tumor-a-comprehensive-updated-review-of-the-literature-and-case-report
#14
Astrid Truschnegg, Stephan Acham, Lumnije Kqiku, Norbert Jakse, Alfred Beham
Prompted by a unique case of an ectomesenchymal chondromyxoid tumor (ECT) of the palate in a 54-year-old female, we reviewed the English and German literature on this entity until the end of 2016 using PubMed. The search produced 74 lingual cases with a nearly equal sex distribution and a mean age of 39.3 years, and two extra-lingual cases sharing histological and immunohistological features including nodular growth, round, fusiform or spindle-shaped cellular architecture, and chondromyxoid stroma. Immunophenotyping showed the majority of cases to be positive for glial fibrillary acidic protein (GFAP), S-100 protein, glycoprotein CD57, pancytokeratin (AE1/AE3), and smooth muscle actin (SMA); in isolated cases there was molecular-genetic rearrangement or gain of Ewing sarcoma breakpoint region 1 (EWSR1) but no rearrangement of pleomorphic adenoma gene 1 (PLAG1)...
February 28, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29483595/rankl-deletion-in-periodontal-ligament-and-bone-lining-cells-blocks-orthodontic-tooth-movement
#15
Chia-Ying Yang, Hyeran Helen Jeon, Ahmed Alshabab, Yu Jin Lee, Chun-Hsi Chung, Dana T Graves
The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand (RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption...
February 26, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29483534/osteocyte-morphology-and-orientation-in-relation-to-strain-in-the-jaw-bone
#16
Vivian Wu, René F M van Oers, Engelbert A J M Schulten, Marco N Helder, Rommel G Bacabac, Jenneke Klein-Nulend
Bone mass is important for dental implant success and is regulated by mechanoresponsive osteocytes. We aimed to investigate the relationship between the levels and orientation of tensile strain and morphology and orientation of osteocytes at different dental implant positions in the maxillary bone. Bone biopsies were retrieved from eight patients who underwent maxillary sinus-floor elevation with β-tricalcium phosphate prior to implant placement. Gap versus free-ending locations were compared using 1) a three-dimensional finite-element model of the maxilla to predict the tensile strain magnitude and direction and 2) histology and histomorphometric analyses...
February 26, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29343681/oral-health-in-china-from-vision-to-action
#17
REVIEW
Xuedong Zhou, Xin Xu, Jiyao Li, Deyu Hu, Tao Hu, Wei Yin, Yujiang Fan, Xingdong Zhang
Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. With this perspective, we described the global challenges of oral diseases, with an emphasis on the challenges faced by China...
January 17, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29319048/analysis-of-differential-expression-of-tight-junction-proteins-in-cultured-oral-epithelial-cells-altered-by-porphyromonas-gingivalis-porphyromonas-gingivalis-lipopolysaccharide-and-extracellular-adenosine-triphosphate
#18
Wei Guo, Peng Wang, Zhong-Hao Liu, Ping Ye
Tight junctions (TJs) are the most apical intercellular junctions of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). Tight junction proteins can sense the presence of bacteria and regulate the transcription of target genes that encode effectors and regulators of the immune response. The aim of this study was to determine the impact of TJ proteins in response to Porphyromonas gingivalis (P. gingivalis), P. gingivalis lipopolysaccharide (P. gingivalis LPS), and extracellular adenosine triphosphate (ATP) in the oral epithelial cell culture model...
January 10, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29235551/interleukin-1%C3%AE-induces-human-cementoblasts-to-support-osteoclastogenesis
#19
Nam C-N Huynh, Vincent Everts, Prasit Pavasant, Ruchanee S Ampornaramveth
Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts. Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin (IL)-1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin. The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology...
December 13, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29593332/the-importance-of-a-potential-phosphorylation-site-in-enamelin-on-enamel-formation
#20
Wen-Juan Yan, Pan Ma, Ye Tian, Jing-Ya Wang, Chun-Lin Qin, Jian Q Feng, Xiao-Fang Wang
Enamelin (ENAM) has three putative phosphoserines (pSers) phosphorylated by a Golgi-associated secretory pathway kinase (FAM20C) based on their distinctive Ser-x-Glu (S-x-E) motifs. Fam20C-knockout mice show severe enamel defects similar to those in the Enam-knockout mice, implying an important role of the pSers in ENAM. To determine the role of pSer55 in ENAM, we characterized ENAMRgsc514 mice, in which Ser55 cannot be phosphorylated by FAM20C due to an E57 >G57 mutation in the S-x-E motif. The enamel microstructure of 4-week-old mice was examined by scanning electron microscopy...
November 29, 2017: International Journal of Oral Science
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