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International Journal of Oral Science

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https://www.readbyqxmd.com/read/28452377/biofilm-three-dimensional-architecture-influences-in-situ-ph-distribution-pattern-on-the-human-enamel-surface
#1
Jin Xiao, Anderson T Hara, Dongyeop Kim, Domenick T Zero, Hyun Koo, Geelsu Hwang
To investigate how the biofilm three-dimensional (3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy...
April 28, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28452376/a-new-approach-to-transfect-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotides-into-the-periodontal-tissue-using-the-ultrasound-microbubble-method
#2
Hiroyuki Yamaguchi, Yuji Ishida, Jun Hosomichi, Jun-Ichi Suzuki, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Takashi Ono
The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low (LUM-Sc) and high (HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble method. Histological inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation (A-Sc)...
April 28, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28452375/evaluation-of-the-osseointegration-of-dental-implants-coated-with-calcium-carbonate-an-animal-study
#3
Yi Liu, Yi Zhou, Tao Jiang, You-De Liang, Zhen Zhang, Yi-Ning Wang
In an attempt to overcome the limitations of titanium in dental and orthopaedic clinical applications, a new method has been developed to prepare calcium carbonate coatings on sandblasted and acid-etched (SA) titanium implants. The purpose of this study was to investigate the effect of calcium carbonate-SA (CC-SA) implants on osseointegration in vivo. The surfaces of SA and CC-SA implants were characterised for surface morphology and surface chemistry. Subsequently, these two kinds of implants were implanted in the femoral condyles of rabbits...
April 28, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28358036/interleukin-1-and-estrogen-protect-against-disseminating-dentoalveolar-infections
#4
Hesham Youssef, Philip Stashenko
Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and neck tissues, resulting in orofacial abscesses, cellulitis and sepsis, with resultant high morbidity and even mortality. In the present studies, we developed a novel model of spreading dentoalveolar infections in mice by treatment with neutralizing antibodies against both interleukin-1α (IL-1α) and IL-1β...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28358035/oral-health-status-in-sichuan-province-findings-from-the-oral-health-survey-of-sichuan-2015-2016
#5
Wei Yin, Ying-Ming Yang, Hong Chen, Xue Li, Zhuo Wang, Li Cheng, Qiu-Dan Yin, Hong-Zhi Fang, Wei Fei, Fang-Lin Mi, Min-Hai Nie, Tao Hu, Xue-Dong Zhou
To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3-5 years, adolescents aged 12 years, and people aged 65-74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28358034/in-silico-identification-of-potential-inhibitors-targeting-streptococcus-mutans-sortase-a
#6
Hao Luo, Dan-Feng Liang, Min-Yue Bao, Rong Sun, Yuan-Yuan Li, Jian-Zong Li, Xin Wang, Kai-Min Lu, Jin-Ku Bao
Dental caries is one of the most common chronic diseases and is caused by acid fermentation of bacteria adhered to the teeth. Streptococcus mutans (S. mutans) utilizes sortase A (SrtA) to anchor surface proteins to the cell wall and forms a biofilm to facilitate its adhesion to the tooth surface. Some plant natural products, especially several flavonoids, are effective inhibitors of SrtA. However, given the limited number of inhibitors and the development of drug resistance, the discovery of new inhibitors is urgent...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28282030/platelet-rich-plasma-for-regeneration-of-neural-feedback-pathways-around-dental-implants-a-concise-review-and-outlook-on-future-possibilities
#7
REVIEW
Yan Huang, Michael M Bornstein, Ivo Lambrichts, Hai-Yang Yu, Constantinus Politis, Reinhilde Jacobs
Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28282029/distribution-of-pericellular-matrix-molecules-in-the-temporomandibular-joint-and-their-chondroprotective-effects-against-inflammation
#8
Wern Cui Chu, Shipin Zhang, Timothy J Sng, Yu Jie Ong, Wen-Li Tan, Vivien Y Ang, Casper B Foldager, Wei Seong Toh
The objectives of this study were to (1) determine the distribution and synthesis of pericellular matrix (PCM) molecules (collagen VI, collagen IV and laminin) in rat temporomandibular joint (TMJ) and (2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones (fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands (anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28233766/low-power-laser-irradiation-inhibits-arecoline-induced-fibrosis-an-in-vitro-study
#9
Mei-Chun Yeh, Ker-Kong Chen, Min-Hsuan Chiang, Chia-Hsin Chen, Ping-Ho Chen, Huey-Er Lee, Yan-Hsiung Wang
Oral submucous fibrosis (OSF) is a potentially malignant disorder that is characterized by a progressive fibrosis in the oral submucosa. Arecoline, an alkaloid compound of the areca nut, is reported to be a major aetiological factor in the development of OSF. Low-power laser irradiation (LPLI) has been reported to be beneficial in fibrosis prevention in different damaged organs. The aim of this study was to investigate the potential therapeutic effects of LPLI on arecoline-induced fibrosis. Arecoline-stimulated human gingival fibroblasts (HGFs) were treated with or without LPLI...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28106044/root-canal-morphology-and-configuration-of-123-maxillary-second-molars-by-means-of-micro-ct
#10
Thomas Gerhard Wolf, Frank Paqué, Anja-Christin Woop, Brita Willershausen, Benjamín Briseño-Marroquín
The aim of this study was to investigate the root canal configuration, accessory canals and number of main foramina of 123 maxillary second molars by means of micro-computed tomography. The teeth were scanned and reproduced with 3D software imaging. The root canal configuration and number of main foramina were evaluated by means of a four-digit system. The morphological complexity of human maxillary second molars is depicted by the number of accessory and connecting canals. The most frequently observed root canal configurations in the mesiobuccal root were 2-2-2/2 (19...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/27811847/novel-rechargeable-calcium-phosphate-nanoparticle-containing-orthodontic-cement
#11
Xian-Ju Xie, Dan Xing, Lin Wang, Han Zhou, Michael D Weir, Yu-Xing Bai, Hockin Hk Xu
White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA)...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28106045/identification-of-shared-and-unique-gene-families-associated-with-oral-clefts
#12
Noriko Funato, Masataka Nakamura
Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip (CL), CL and/or palate (CL/P) and cleft palate (CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained...
January 20, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/27982023/spatial-signalling-mediated-by-the-transforming-growth-factor-%C3%AE-signalling-pathway-during-tooth-formation
#13
Xin-Yu He, Ke Sun, Ruo-Shi Xu, Jia-Li Tan, Cai-Xia Pi, Mian Wan, Yi-Ran Peng, Ling Ye, Li-Wei Zheng, Xue-Dong Zhou
Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27910940/supportive-angiogenic-and-osteogenic-differentiation-of-mesenchymal-stromal-cells-and-endothelial-cells-in-monolayer-and-co-cultures
#14
Florian Böhrnsen, Henning Schliephake
Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-derived mesenchymal stromal cells (BMSCs) and endothelial cells (ECs) contribute to cellular proangiogenic differentiation, we analysed the differentiation of BMSCs and ECs in standardized monolayer, Transwell and co-cultures...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27857074/second-premolar-agenesis-is-associated-with-mandibular-form-a-geometric-morphometric-analysis-of-mandibular-cross-sections
#15
Michael H Bertl, Kristina Bertl, Manuel Wagner, André Gahleitner, Andreas Stavropoulos, Christian Ulm, Philipp Mitteroecker
The aim of this study was to compare mandibular form (i.e., size and shape) between patients with agenesis of the lower second premolar (P2) and a control group with no agenesis. Three hypotheses were tested: (H1) agenesis causes a change in mandibular morphology because of inadequate alveolar ridge development in the area of the missing tooth (mandibular plasticity); (H2) agenesis is caused by spatial limitations within the mandible (dental plasticity); and (H3) common genetic/epigenetic factors cause agenesis and affect mandibular form (pleiotropy)...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27811846/primer-containing-dimethylaminododecyl-methacrylate-kills-bacteria-impregnated-in-human-dentin-blocks
#16
Chen Chen, Lei Cheng, Michael D Weir, Nancy J Lin, Sheng Lin-Gibson, Xue-Dong Zhou, Hockin Hk Xu
Antibacterial dimethylaminododecyl methacrylate (DMADDM) was recently synthesized. The objectives of this study were to: (1) investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and (2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate (QADM). Scotchbond Multi-Purpose (SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27811845/dental-pulp-stem-cells-express-tendon-markers-under-mechanical-loading-and-are-a-potential-cell-source-for-tissue-engineering-of-tendon-like-tissue
#17
Yu-Ying Chen, Sheng-Teng He, Fu-Hua Yan, Peng-Fei Zhou, Kai Luo, Yan-Ding Zhang, Yin Xiao, Min-Kui Lin
Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenomodulin, eye absent homologue 2, collagens I and VI was detected in dental pulp tissue. Interestingly, under mechanical stimulation, these tendon-related markers were significantly enhanced when DPSCs were seeded in aligned polyglycolic acid (PGA) fibre scaffolds...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27767053/globoside-accelerates-the-differentiation-of-dental-epithelial-cells-into-ameloblasts
#18
Takashi Nakamura, Yuta Chiba, Masahiro Naruse, Kan Saito, Hidemitsu Harada, Satoshi Fukumoto
Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside (Gb4), a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly expressed in the neutral lipid fraction of dental epithelial cells. However, because its functional role in tooth development remains unknown, we investigated the involvement of Gb4 in dental epithelial cell differentiation...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27740612/alanine-racemase-is-essential-for-the-growth-and-interspecies-competitiveness-of-streptococcus-mutans
#19
Yuan Wei, Wei Qiu, Xue-Dong Zhou, Xin Zheng, Ke-Ke Zhang, Shi-Da Wang, Yu-Qing Li, Lei Cheng, Ji-Yao Li, Xin Xu, Ming-Yun Li
D-alanine (D-Ala) is an essential amino acid that has a key role in bacterial cell wall synthesis. Alanine racemase (Alr) is a unique enzyme that interconverts L-alanine and D-alanine in most bacteria, making this enzyme a potential target for antimicrobial drug development. Streptococcus mutans is a major causative factor of dental caries. The factors involved in the survival, virulence and interspecies interactions of S. mutans could be exploited as potential targets for caries control. The current study aimed to investigate the physiological role of Alr in S...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27660048/colour-stabilities-of-three-types-of-orthodontic-clear-aligners-exposed-to-staining-agents
#20
Chen-Lu Liu, Wen-Tian Sun, Wen Liao, Wen-Xin Lu, Qi-Wen Li, Yunho Jeong, Jun Liu, Zhi-He Zhao
The aim of this study was to evaluate and compare the colour stabilities of three types of orthodontic clear aligners exposed to staining agents in vitro. Sixty clear orthodontic aligners produced by three manufacturers (Invisalign, Angelalign, and Smartee) were immersed in three staining solutions (coffee, black tea, and red wine) and one control solution (distilled water). After 12-h and 7-day immersions, the aligners were washed in an ultrasonic cleaner and measured with a colourimeter. The colour changes (ΔE*) were calculated on the basis of the Commission Internationale de I'Eclairage L*a*b* colour system (CIE L*a*b*), and the results were then converted into National Bureau of Standards (NBS) units...
December 16, 2016: International Journal of Oral Science
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