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International Journal of Oral Science

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https://www.readbyqxmd.com/read/28884743/three-dimensional-analysis-of-the-physiological-foramen-geometry-of-maxillary-and-mandibular-molars-by-means-of-micro-ct
#1
Thomas Gerhard Wolf, Frank Paqué, Michael Sven Patyna, Brita Willershausen, Benjamín Briseño-Marroquín
The aim of this study was to investigate the physiological foramen diameter, shape and distance between physiological and anatomical apex of maxillary and mandibular first and second molars. Accurate knowledge of the physiological foramina morphology; thus, inherent mechanical shaping technical hindrances, is decisive when taking the corresponding root canal final preparation decision. The morphological dimensions of a total of 1727 physiological foramina were investigated by means of micro-computed tomography...
September 8, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29125139/salivary-proteins-and-microbiota-as-biomarkers-for-early-childhood-caries-risk-assessment
#2
REVIEW
Abdullah S Hemadi, Ruijie Huang, Yuan Zhou, Jing Zou
Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29125138/detection-accuracy-for-epithelial-dysplasia-using-an-objective-autofluorescence-visualization-method-based-on-the-luminance-ratio
#3
Nanami Yamamoto, Koji Kawaguchi, Hisako Fujihara, Mitsuhiko Hasebe, Yuta Kishi, Masaaki Yasukawa, Kenichi Kumagai, Yoshiki Hamada
The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma (SCC) were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope (VELscope), and the iodine-staining method was then performed...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28960195/doxycycline-induces-bone-repair-and-changes-in-wnt-signalling
#4
Kátia do Nascimento Gomes, Ana Paula Negreiros Nunes Alves, Paula Góes Pinheiro Dutra, Glauce Socorro de Barros Viana
Doxycycline (DOX) exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls (CTL) and DOX-treated (10 and 25 mg·kg(-1)) molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays. Hematoxylin-eosin staining (7th day) revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate...
September 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28960194/regular-nicotine-intake-increased-tooth-movement-velocity-osteoclastogenesis-and-orthodontically-induced-dental-root-resorptions-in-a-rat-model
#5
Christian Kirschneck, Michael Maurer, Michael Wolf, Claudia Reicheneder, Peter Proff
Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each (A/B/C) to 3 experimental groups (7 rats, 1/2/3): (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C) reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR)/cotinine serology-(1) control; (2) orthodontic tooth movement (OTM) of the first and second upper left molar (NiTi closed coil spring, 0...
September 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28960193/an-early-report-a-modified-porphyrin-linked-metronidazole-targeting-intracellular-porphyromonas-gingivalis-in-cultured-oral-epithelial-cells
#6
Ping Ye, Jiho Chang, Lin Feng Foo, Benjamin C-M Yap
Porphyromonas gingivalis (P. gingivalis) has a strong association with the pathogenesis of periodontal disease. Recurrence of periodontal disease following therapy is attributed to numerous factors, and of growing interest is the potential problem of intracellular bacteria that are able to persist and multiply within the host cell, thereby facilitating relapse of infection. The effect of antibiotic therapy in controlling P. gingivalis is questionable. Accordingly, while metronidazole is very effective against anaerobic extracellular P...
September 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28644432/dental-implant-treatment-for-renal-failure-patients-on-dialysis-a-clinical-guideline
#7
REVIEW
Quan Yuan, Qiu-Chan Xiong, Megha Gupta, Rosa María López-Pintor, Xiao-Lei Chen, Dutmanee Seriwatanachai, Michael Densmore, Yi Man, Ping Gong
Chronic kidney disease (CKD) is a worldwide public health problem that is growing in prevalence and is associated with severe complications. During the progression of the disease, a majority of CKD patients suffer oral complications. Dental implants are currently the most reliable and successful treatment for missing teeth. However, due to complications of CKD such as infections, bone lesions, bleeding risks, and altered drug metabolism, dental implant treatment for renal failure patients on dialysis is more challenging...
September 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28708129/validation-of-a-novel-imaging-approach-using-multi-slice-ct-and-cone-beam-ct-to-follow-up-on-condylar-remodeling-after-bimaxillary-surgery
#8
Laura Ferreira Pinheiro Nicolielo, Jeroen Van Dessel, Eman Shaheen, Carolina Letelier, Marina Codari, Constantinus Politis, Ivo Lambrichts, Reinhilde Jacobs
The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography (MSCT) and postoperative cone-beam computed tomography (CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients (11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D...
July 14, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28621325/the-oral-commensal-streptococcus-mitis-activates-the-aryl-hydrocarbon-receptor-in-human-oral-epithelial-cells
#9
Stian A Engen, Gro H Rørvik, Olav Schreurs, Inger Js Blix, Karl Schenck
Streptococcus mitis (S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor (AhR). Activation and functionality of AhR was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for AhR activation...
June 16, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28660906/robotic-surgical-systems-in-maxillofacial-surgery-a-review
#10
REVIEW
Hang-Hang Liu, Long-Jiang Li, Bin Shi, Chun-Wei Xu, En Luo
Throughout the twenty-first century, robotic surgery has been used in multiple oral surgical procedures for the treatment of head and neck tumors and non-malignant diseases. With the assistance of robotic surgical systems, maxillofacial surgery is performed with less blood loss, fewer complications, shorter hospitalization and better cosmetic results than standard open surgery. However, the application of robotic surgery techniques to the treatment of head and neck diseases remains in an experimental stage, and the long-lasting effects on surgical morbidity, oncologic control and quality of life are yet to be established...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28644431/an-in-vitro-study-on-the-efficacy-of-removing-calcium-hydroxide-from-curved-root-canal-systems-in-root-canal-therapy
#11
Ying Wang, Li-Yang Guo, Hong-Zhi Fang, Wen-Ling Zou, Ying-Ming Yang, Yuan Gao, Hui Yang, Tao Hu
To compare the efficacy of various irrigants (citric acid, ethylenediaminetetraacetic acid (EDTA) and NaOCl) and techniques in removing Ca(OH)2 in two types of curved root canal systems, simulated root canals with specific curvatures were used to investigate the effects of different irrigants and instruments on Ca(OH)2 removal. The optimal methods were verified on extracted human teeth. Simulated root canals were assigned to one of two groups based on the irrigation solution: 10% citric acid or 2.5% NaOCl. Each group was divided into four subgroups according to the technique used to remove Ca(OH)2...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28621326/resin-infiltration-of-deproteinised-natural-occlusal-subsurface-lesions-improves-initial-quality-of-fissure-sealing
#12
Andrej M Kielbassa, Ina Ulrich, Rita Schmidl, Christoph Schüller, Wilhelm Frank, Vanessa D Werth
The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin (RI/CR) when used with deproteinised and etched occlusal subsurface lesions (International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin (CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using NaOCl (2%)...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28621324/marginal-bone-loss-around-non-submerged-implants-is-associated-with-salivary-microbiome-during-bone-healing
#13
Xiao-Bo Duan, Ting-Xi Wu, Yu-Chen Guo, Xue-Dong Zhou, Yi-Ling Lei, Xin Xu, An-Chun Mo, Yong-Yue Wang, Quan Yuan
Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundred patients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomography during a 3-month healing period. The patients were divided into three groups according to the severity of marginal bone loss. Saliva samples were collected from all subjected and were analysed using 16S MiSeq sequencing...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28621323/a-robust-methodology-for-the-quantitative-assessment-of-the-rat-jawbone-microstructure
#14
Marissa Chatterjee, Fernanda Faot, Cassia Correa, Joke Duyck, Ignace Naert, Katleen Vandamme
Micro-computed tomography can be applied for the assessment of the micro-architectural characteristics of the cortical and trabecular bones in either physiological or disease conditions. However, reports often lack a detailed description of the methodological steps used to analyse these images, such as the volumes of interest, the algorithms used for image filtration, the approach used for image segmentation, and the bone parameters quantified, thereby making it difficult to compare or reproduce the studies...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28452377/biofilm-three-dimensional-architecture-influences-in-situ-ph-distribution-pattern-on-the-human-enamel-surface
#15
Jin Xiao, Anderson T Hara, Dongyeop Kim, Domenick T Zero, Hyun Koo, Geelsu Hwang
To investigate how the biofilm three-dimensional (3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28452376/a-new-approach-to-transfect-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotides-into-the-periodontal-tissue-using-the-ultrasound-microbubble-method
#16
Hiroyuki Yamaguchi, Yuji Ishida, Jun Hosomichi, Jun-Ichi Suzuki, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Takashi Ono
The objective of this study is to investigate the effect of the ultrasound-microbubble technique in nuclear factor kappa B (NF-κB) decoy oligodeoxynucleotide (ODN) transfection in the gingival tissue in mice. The 6-FAM-labeled scrambled decoy ODN with microbubbles was applied to the periodontal tissue in 8-week-old male C57BL/6J mice by ultrasound radiation at low (LUM-Sc) and high (HUM-Sc) intensities to optimize the transfection condition of the ultrasound-microbubble method. Histological inspections were performed two hours after transfection to compare the expression with that in the sham-operated group without ultrasound radiation (A-Sc)...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28106045/identification-of-shared-and-unique-gene-families-associated-with-oral-clefts
#17
Noriko Funato, Masataka Nakamura
Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip (CL), CL and/or palate (CL/P) and cleft palate (CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained...
June 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28452375/evaluation-of-the-osseointegration-of-dental-implants-coated-with-calcium-carbonate-an-animal-study
#18
Yi Liu, Yi Zhou, Tao Jiang, You-De Liang, Zhen Zhang, Yi-Ning Wang
In an attempt to overcome the limitations of titanium in dental and orthopaedic clinical applications, a new method has been developed to prepare calcium carbonate coatings on sandblasted and acid-etched (SA) titanium implants. The purpose of this study was to investigate the effect of calcium carbonate-SA (CC-SA) implants on osseointegration in vivo. The surfaces of SA and CC-SA implants were characterised for surface morphology and surface chemistry. Subsequently, these two kinds of implants were implanted in the femoral condyles of rabbits...
April 28, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28358036/interleukin-1-and-estrogen-protect-against-disseminating-dentoalveolar-infections
#19
Hesham Youssef, Philip Stashenko
Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and neck tissues, resulting in orofacial abscesses, cellulitis and sepsis, with resultant high morbidity and even mortality. In the present studies, we developed a novel model of spreading dentoalveolar infections in mice by treatment with neutralizing antibodies against both interleukin-1α (IL-1α) and IL-1β...
March 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28358035/oral-health-status-in-sichuan-province-findings-from-the-oral-health-survey-of-sichuan-2015-2016
#20
Wei Yin, Ying-Ming Yang, Hong Chen, Xue Li, Zhuo Wang, Li Cheng, Qiu-Dan Yin, Hong-Zhi Fang, Wei Fei, Fang-Lin Mi, Min-Hai Nie, Tao Hu, Xue-Dong Zhou
To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3-5 years, adolescents aged 12 years, and people aged 65-74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0...
March 2017: International Journal of Oral Science
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