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International Journal of Oral Science

https://read.qxmd.com/read/38480698/a-wnt10a-notch-signaling-axis-controls-hertwig-s-epithelial-root-sheath-cell-behaviors-during-root-furcation-patterning
#1
JOURNAL ARTICLE
Kai Sun, Miao Yu, Jiayu Wang, Hu Zhao, Haochen Liu, Hailan Feng, Yang Liu, Dong Han
Human with bi-allelic WNT10A mutations and epithelial Wnt10a knockout mice present enlarged pulp chamber and apical displacement of the root furcation of multi-rooted teeth, known as taurodontism; thus, indicating the critical role of Wnt10a in tooth root morphogenesis. However, the endogenous mechanism by which epithelial Wnt10a regulates Hertwig's epithelial root sheath (HERS) cellular behaviors and contributes to root furcation patterning remains unclear. In this study, we found that HERS in the presumptive root furcating region failed to elongate at an appropriate horizontal level in K14-Cre;Wnt10afl/fl mice from post-natal day 0...
March 13, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38472176/promising-dawn-in-tumor-microenvironment-therapy-engineering-oral-bacteria
#2
REVIEW
Zifei Wang, Wansu Sun, Ruixue Hua, Yuanyin Wang, Yang Li, Hengguo Zhang
Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of oral microbes in the development and progression of cancer has received increasing scrutiny. At the same time, bioengineering technology and nanotechnology is growing rapidly, in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of cancers...
March 13, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38429299/expert-consensus-on-irrigation-and-intracanal-medication-in-root-canal-therapy
#3
REVIEW
Xiaoying Zou, Xin Zheng, Yuhong Liang, Chengfei Zhang, Bing Fan, Jingping Liang, Junqi Ling, Zhuan Bian, Qing Yu, Benxiang Hou, Zhi Chen, Xi Wei, Lihong Qiu, Wenxia Chen, Wenxi He, Xin Xu, Liuyan Meng, Chen Zhang, Liming Chen, Shuli Deng, Yayan Lei, Xiaoli Xie, Xiaoyan Wang, Jinhua Yu, Jin Zhao, Song Shen, Xuedong Zhou, Lin Yue
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal medication and non-standardized dressing protocols must be clarified. Inappropriate intracanal medication may present side effects and jeopardize the therapeutic outcomes...
March 1, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38429281/expert-consensus-on-difficulty-assessment-of-endodontic-therapy
#4
REVIEW
Dingming Huang, Xiaoyan Wang, Jingping Liang, Junqi Ling, Zhuan Bian, Qing Yu, Benxiang Hou, Xinmei Chen, Jiyao Li, Ling Ye, Lei Cheng, Xin Xu, Tao Hu, Hongkun Wu, Bin Guo, Qin Su, Zhi Chen, Lihong Qiu, Wenxia Chen, Xi Wei, Zhengwei Huang, Jinhua Yu, Zhengmei Lin, Qi Zhang, Deqin Yang, Jin Zhao, Shuang Pan, Jian Yang, Jiayuan Wu, Yihuai Pan, Xiaoli Xie, Shuli Deng, Xiaojing Huang, Lan Zhang, Lin Yue, Xuedong Zhou
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy (RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system's anatomy intricacies and the technique sensitivity of RCT...
March 1, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38424060/single-cell-transcriptomics-reveals-cell-atlas-and-identifies-cycling-tumor-cells-responsible-for-recurrence-in-ameloblastoma
#5
JOURNAL ARTICLE
Gan Xiong, Nan Xie, Min Nie, Rongsong Ling, Bokai Yun, Jiaxiang Xie, Linlin Ren, Yaqi Huang, Wenjin Wang, Chen Yi, Ming Zhang, Xiuyun Xu, Caihua Zhang, Bin Zou, Leitao Zhang, Xiqiang Liu, Hongzhang Huang, Demeng Chen, Wei Cao, Cheng Wang
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a high recurrence rate. However, the mechanisms governing tumor initiation and recurrence are poorly understood. Here, we uncovered cellular landscapes and mechanisms that underlie tumor recurrence in ameloblastoma at single-cell resolution. Our results revealed that ameloblastoma exhibits five tumor subpopulations varying with respect to immune response (IR), bone remodeling (BR), tooth development (TD), epithelial development (ED), and cell cycle (CC) signatures...
February 29, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38418808/tim4-deficiency-reduces-cd301b-macrophage-and-aggravates-periodontitis-bone-loss
#6
JOURNAL ARTICLE
Ziming Wang, Hao Zeng, Can Wang, Jiaolong Wang, Jing Zhang, Shuyuan Qu, Yue Han, Liu Yang, Yueqi Ni, Wenan Peng, Huan Liu, Hua Tang, Qin Zhao, Yufeng Zhang
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth loss. With the progression of periodontitis, the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone resorption. CD301b+ macrophages are specific to the osteoimmunology microenvironment, and are emerging as vital booster for conducting bone regeneration. However, the key upstream targets of CD301b+ macrophages and their potential mechanism in periodontitis remain elusive...
February 28, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38418457/the-osteoclastic-activity-in-apical-distal-region-of-molar-mesial-roots-affects-orthodontic-tooth-movement-and-root-resorption-in-rats
#7
JOURNAL ARTICLE
Wenhao Zheng, Xiaofeng Lu, Guangjin Chen, Yufeng Shen, Xiaofei Huang, Jinfeng Peng, Jiajia Wang, Ying Yin, Wencheng Song, Mengru Xie, Shaoling Yu, Lili Chen
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and the criteria for evaluating optimal force have not been yet established. Here, by employing 3D finite element analysis methodology, we found that the apical distal region (A-D region) of mesial roots is particularly sensitive to orthodontic force in rats. Tartrate-resistant acidic phosphatase (TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams (g), leading to alveolar bone resorption and tooth movement...
February 28, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38413562/the-neutrophil-osteogenic-cell-axis-promotes-bone-destruction-in-periodontitis
#8
JOURNAL ARTICLE
Yutaro Ando, Masayuki Tsukasaki, Nam Cong-Nhat Huynh, Shizao Zang, Minglu Yan, Ryunosuke Muro, Kazutaka Nakamura, Masatsugu Komagamine, Noriko Komatsu, Kazuo Okamoto, Kenta Nakano, Tadashi Okamura, Akira Yamaguchi, Kazuyuki Ishihara, Hiroshi Takayanagi
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune-bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNA-sequencing analysis on mouse periodontal lesions and showed that neutrophil-osteogenic cell crosstalk is involved in periodontitis-induced bone loss...
February 27, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38403794/stromal-thrombospondin-1-suppresses-angiogenesis-in-oral-submucous-fibrosis
#9
JOURNAL ARTICLE
Xiao Yang, Hui Zhao, Rui Li, Yang Chen, Zhi Xu, Zhengjun Shang
A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that is largely induced by betel quid chewing. However, the lack of available models has challenged studies of angiogenesis in OSF. Here, we found that the expression of thrombospondin 1 (THBS1), an endogenous angiostatic protein, was elevated in the stroma of tissues with OSF. Using a fibroblast-attached organoid (FAO) model, the overexpression of THBS1 in OSF was stably recapitulated in vitro...
February 26, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38403665/digital-pathology-based-artificial-intelligence-models-for-differential-diagnosis-and-prognosis-of-sporadic-odontogenic-keratocysts
#10
JOURNAL ARTICLE
Xinjia Cai, Heyu Zhang, Yanjin Wang, Jianyun Zhang, Tiejun Li
Odontogenic keratocyst (OKC) is a common jaw cyst with a high recurrence rate. OKC combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin syndrome. Moreover, OKC needs to be differentiated from orthokeratinized odontogenic cyst and other jaw cysts. Because of the different prognosis, differential diagnosis of several cysts can contribute to clinical management. We collected 519 cases, comprising a total of 2 157 hematoxylin and eosin-stained images, to develop digital pathology-based artificial intelligence (AI) models for the diagnosis and prognosis of OKC...
February 26, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38369512/prx1-positive-mesenchymal-stem-cells-drive-molar-morphogenesis
#11
JOURNAL ARTICLE
Xiaoqiao Xu, Xuyan Gong, Lei Zhang, Han Zhang, Yao Sun
Mammalian teeth, developing inseparable from epithelial-mesenchymal interaction, come in many shapes and the key factors governing tooth morphology deserve to be answered. By merging single-cell RNA sequencing analysis with lineage tracing models, we have unearthed a captivating correlation between the contrasting morphology of mouse molars and the specific presence of PRX1+ cells within M1. These PRX1+ cells assume a profound responsibility in shaping tooth morphology through a remarkable divergence in dental mesenchymal cell proliferation...
February 19, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38368395/a-novel-saliva-based-mirna-profile-to-diagnose-and-predict-oral-cancer
#12
JOURNAL ARTICLE
Jaikrishna Balakittnen, Chameera Ekanayake Weeramange, Daniel F Wallace, Pascal H G Duijf, Alexandre S Cristino, Gunter Hartel, Roberto A Barrero, Touraj Taheri, Liz Kenny, Sarju Vasani, Martin Batstone, Omar Breik, Chamindie Punyadeera
Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD). The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs...
February 18, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38368361/genomic-alterations-in-oral-multiple-primary-cancers
#13
JOURNAL ARTICLE
Xuan Zhou, Xinjia Cai, Fengyang Jing, Xuefen Li, Jianyun Zhang, Heyu Zhang, Tiejun Li
Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n = 202) and oral MPCs (n = 34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis...
February 18, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38311610/cd97-inhibits-osteoclast-differentiation-via-rap1a-erk-pathway-under-compression
#14
JOURNAL ARTICLE
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force sensing. However, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages...
February 4, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38302479/expert-consensus-on-odontogenic-maxillary-sinusitis-multi-disciplinary-treatment
#15
REVIEW
Jiang Lin, Chengshuo Wang, Xiangdong Wang, Faming Chen, Wei Zhang, Hongchen Sun, Fuhua Yan, Yaping Pan, Dongdong Zhu, Qintai Yang, Shaohua Ge, Yao Sun, Kuiji Wang, Yuan Zhang, Mu Xian, Ming Zheng, Anchun Mo, Xin Xu, Hanguo Wang, Xuedong Zhou, Luo Zhang
Odontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS...
February 1, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38296940/magnesium-promotes-vascularization-and-osseointegration-in-diabetic-states
#16
JOURNAL ARTICLE
Linfeng Liu, Feiyu Wang, Wei Song, Danting Zhang, Weimin Lin, Qi Yin, Qian Wang, Hanwen Li, Quan Yuan, Shiwen Zhang
Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes angiogenesis and osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis...
January 31, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38287007/spatial-transcriptomics-reveals-that-metabolic-characteristics-define-the-tumor-immunosuppression-microenvironment-via-icaf-transformation-in-oral-squamous-cell-carcinoma
#17
JOURNAL ARTICLE
Zheqi Liu, Zhen Zhang, Yu Zhang, Wenkai Zhou, Xu Zhang, Canbang Peng, Tong Ji, Xin Zou, Zhiyuan Zhang, Zhenhu Ren
Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data...
January 30, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38272860/publisher-correction-nitrate-reduction-capacity-of-the-oral-microbiota-is-impaired-in-periodontitis-potential-implications-for-systemic-nitric-oxide-availability
#18
Bob T Rosier, William Johnston, Miguel Carda-DiƩguez, Annabel Simpson, Elena Cabello-Yeves, Krystyna Piela, Robert Reilly, Alejandro Artacho, Chris Easton, Mia Burleigh, Shauna Culshaw, Alex Mira
No abstract text is available yet for this article.
January 26, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38246919/wnt7a-promotes-tumorigenesis-of-head-and-neck-squamous-cell-carcinoma-via-activating-fzd7-jak1-stat3-signaling
#19
JOURNAL ARTICLE
Qingling Huang, Yi Xiao, Ting Lan, Youguang Lu, Li Huang, Dali Zheng
Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry...
January 22, 2024: International Journal of Oral Science
https://read.qxmd.com/read/38246918/rnps1-stabilizes-nat10-protein-to-facilitate-translation-in-cancer-via-trna-ac-4-c-modification
#20
JOURNAL ARTICLE
Xiaochen Wang, Rongsong Ling, Yurong Peng, Weiqiong Qiu, Demeng Chen
Existing studies have underscored the pivotal role of N-acetyltransferase 10 (NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma (HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1 (RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6 (ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC...
January 22, 2024: International Journal of Oral Science
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