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International Journal of Oral Science

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https://www.readbyqxmd.com/read/30420594/increased-virulence-of-the-oral-microbiome-in-oral-squamous-cell-carcinoma-revealed-by-metatranscriptome-analyses
#1
Susan Yost, Philip Stashenko, Yoonhee Choi, Maria Kukuruzinska, Caroline A Genco, Andrew Salama, Ellen O Weinberg, Carolyn D Kramer, Jorge Frias-Lopez
Oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease...
November 12, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30393383/the-functional-significance-of-dentin-sialoprotein-phosphophoryn-and-dentin-sialoprotein
#2
Helena Ritchie
Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Historically, these two proteins were considered to be independently synthesized and secreted by dental pulp cells into the developing dentin matrix. However, with the identification of the DSP coding sequence in 1994, followed 2 years later by the finding that the PP coding sequence was located immediately downstream from the DSP sequence, it became immediately clear that DSP and PP proteins were derived from a single DSP-PP (i...
November 5, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30344309/erk-phosphorylation-functions-in-invadopodia-formation-in-tongue-cancer-cells-in-a-novel-silicate-fibre-based-3d-cell-culture-system
#3
Masaharu Noi, Ken-Ichi Mukaisho, Saori Yoshida, Shoko Murakami, Shinya Koshinuma, Takeshi Adachi, Yoshisato Machida, Masashi Yamori, Takahisa Nakayama, Gaku Yamamoto, Hiroyuki Sugihara
To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase (ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet CellbedTM with a structure resembling the loose connective tissue morphology in a novel 3D culture system...
October 22, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30297828/tgf-%C3%AE-2-downregulates-osteogenesis-under-inflammatory-conditions-in-dental-follicle-stem-cells
#4
Soyoun Um, Joo-Hee Lee, Byoung-Moo Seo
Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation. Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells (DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed...
October 9, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30174330/whole-exome-sequencing-identifies-an-ambn-missense-mutation-causing-severe-autosomal-dominant-amelogenesis-imperfecta-and-dentin-disorders
#5
Ting Lu, Meiyi Li, Xiangmin Xu, Jun Xiong, Cheng Huang, Xuelian Zhang, Aiqin Hu, Ling Peng, Decheng Cai, Leitao Zhang, Buling Wu, Fu Xiong
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta (AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth...
September 3, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30174329/selective-serotonin-re-uptake-inhibitor-sertraline-inhibits-bone-healing-in-a-calvarial-defect-model
#6
R Nicole Howie, Samuel Herberg, Emily Durham, Zachary Grey, Grace Bennfors, Mohammed Elsalanty, Amanda C LaRue, William D Hill, James J Cray
Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma...
September 3, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30111835/transcriptional-activation-of-glucose-transporter-1-in-orthodontic-tooth-movement-associated-mechanical-response
#7
Yu Wang, Qian Li, Fuliang Liu, Shanshan Jin, Yimei Zhang, Ting Zhang, Yunyan Zhu, Yanheng Zhou
The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression, growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified glucose transporter 1 (GLUT1)-the primary glucose transporter in various cells-as a novel mechanosensitive gene in orthodontic tooth movement (OTM). Using an in vivo rat OTM model, we demonstrated the specific induction of Glut1 proteins on the compressive side of a physically strained periodontal ligament...
August 15, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30111787/meeting-report-a-close-look-at-oral-biofilms-and-microbiomes
#8
Xin Xu, Feng Chen, Zhengwei Huang, Lvyan Ma, Li Chen, Yaping Pan, Jian Xu, Syngcuk Kim, Denis Kinane, Hyun Koo, Xuedong Zhou
The "Biofilms, Microbiomes and Oral Diseases: Challenges and Future Perspectives" symposium jointly organized by Penn Dental Medicine and West China School of Stomatology was held on 30 September 2017 at Penn Wharton China Center (PWCC) in Beijing, China. The topics included the pathogenicity of oral biofilms, novel strategies for the control of biofilm-related diseases, oral microbiome and single-cell approaches, and the link between oral diseases and overall health. Researchers from a number of disciplines, representing institutions from China and Penn Dental Medicine, gathered to discuss advances in our understanding of biofilms, as well as future directions for the control of biofilm-related oral and systemic diseases...
August 15, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30078842/micrornas-and-immunity-in-periodontal-health-and-disease
#9
Xianghong Luan, Xiaofeng Zhou, Afsar Naqvi, Marybeth Francis, Deborah Foyle, Salvador Nares, Thomas G H Diekwisch
MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Previous human studies have highlighted some key miRNAs that are dysregulated in periodontitis patients...
August 6, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30078841/streptococcus-mutans-activates-the-aim2-nlrp3-and-nlrc4-inflammasomes-in-human-thp-1-macrophages
#10
Yuri Song, Hee Sam Na, Eunjoo Park, Mi Hee Park, Hyun Ah Lee, Jin Chung
Streptococcus mutans (S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin (IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S...
August 6, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29967411/effect-of-low-level-laser-therapy-on-tooth-related-pain-and-somatosensory-function-evoked-by-orthodontic-treatment
#11
Song Wu, Yinan Chen, Jinglu Zhang, Wenjing Chen, Sheng Shao, Huijie Shen, Ling Zhu, Ping Ye, Peter Svensson, Kelun Wang
Low-level laser therapy (LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals (12-33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group (LG) or a placebo group (PG) (1:1). The LG received LLLT (810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm-2 ) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points...
July 2, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29961761/epithelial-cell-adhesion-efficacy-of-a-novel-peptide-identified-by-panning-on-a-smooth-titanium-surface
#12
Hidemichi Kihara, David M Kim, Masazumi Nagai, Toshiki Nojiri, Shigemi Nagai, Chia-Yu Chen, Cliff Lee, Wataru Hatakeyama, Hisatomo Kondo, John Da Silva
Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide (A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized...
July 2, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29925870/effects-of-water-aging-for-6-months-on-the-durability-of-a-novel-antimicrobial-and-protein-repellent-dental-bonding-agent
#13
Ning Zhang, Ke Zhang, Michael D Weir, David J Xu, Mark A Reynolds, Yuxing Bai, Hockin H K Xu
Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability...
June 21, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29895944/local-icariin-application-enhanced-periodontal-tissue-regeneration-and-relieved-local-inflammation-in-a-minipig-model-of-periodontitis
#14
Xiuli Zhang, Nannan Han, Guoqing Li, Haoqing Yang, Yangyang Cao, Zhipeng Fan, Fengqiu Zhang
Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis...
June 12, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29895828/bone-conditioned-medium-contributes-to-initiation-and-progression-of-osteogenesis-by-exhibiting-synergistic-tgf-%C3%AE-1-bmp-2-activity
#15
Maria B Asparuhova, Jordi Caballé-Serrano, Daniel Buser, Vivianne Chappuis
Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral (DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells...
June 12, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29777107/differentiation-of-periapical-granulomas-and-cysts-by-using-dental-mri-a-pilot-study
#16
Alexander Juerchott, Thorsten Pfefferle, Christa Flechtenmacher, Johannes Mente, Martin Bendszus, Sabine Heiland, Tim Hilgenfeld
The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging (MRI). Prior to apicoectomy, 11 patients with radiographically confirmed periapical lesions underwent dental MRI, including fat-saturated T2-weighted (T2wFS) images, non-contrast-enhanced T1-weighted images with and without fat saturation (T1w/T1wFS), and contrast-enhanced fat-saturated T1-weighted (T1wFS+C) images. Two independent observers performed structured image analysis of MRI datasets twice...
May 17, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29748557/recombinant-amelogenin-regulates-the-bioactivity-of-mouse-cementoblasts-in-vitro
#17
Sema S Hakki, S Buket Bozkurt, Emre Türkay, Michel Dard, Nuhan Purali, Werner Götz
Amelogenin (AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG (rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts (OCCM-30) were treated with different concentrations (0.1, 1, 10, 100, 1000, 10,000, 100,000 ng · mL-1 ) of recombinant human AMG (rhAMG) and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein (BSP), osteocalcin (OCN), collagen type I (COL I), osteopontin (OPN), runt-related transcription factor 2 (Runx2), cementum attachment protein (CAP), and alkaline phosphatase (ALP) genes using quantitative RT-PCR...
May 9, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29760467/the-oral-microbiome-bank-of-china
#18
Peng Xian, Zhou Xuedong, Xu Xin, Li Yuqing, Li Yan, Li Jiyao, Su Xiaoquan, Huang Shi, Xu Jian, Liao Ga
The human microbiome project (HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database (HOMD) was established in the US...
May 3, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29695713/autonomic-reinnervation-and-functional-regeneration-in-autologous-transplanted-submandibular-glands-in-patients-with-severe-keratoconjunctivitis-sicca
#19
Xueming Zhang, Ningyan Yang, Xiaojing Liu, Jiazeng Su, Xin Cong, Liling Wu, Yan Zhang, Guangyan Yu
Autologous submandibular gland (SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously. This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Parts of the transplanted SMGs were collected from the epiphora patients, and a rabbit SMG transplantation model was established to fulfill the serial observation on the transplanted glands with time...
April 25, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/29686224/activation-of-%C3%AE-catenin-signaling-in-aggrecan-expressing-cells-in-temporomandibular-joint-causes-osteoarthritis-like-defects
#20
Tianqian Hui, Yachuan Zhou, Tingyu Wang, Jun Li, Shanxing Zhang, Lifan Liao, Jianhong Gu, Ling Ye, Lan Zhao, Di Chen
β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular joint (TMJ), we have generated β-catenin conditional activation mice (β-cat(ex3) Agc1CreER ) by breeding Agc1-CreER mice with β-cateninflox(ex3)/+ mice. Results of histologic analysis showed the progressive TMJ defects in 3- and 6-month-old β-cat(ex3) Agc1CreER mice (tamoxifen induction was performed at 2 weeks of age), including decreased chondrocyte numbers in the superficial layer associated with less Alcian blue staining, increased numbers of hypertrophic chondrocytes in deep layers, and rough articular surface...
April 23, 2018: International Journal of Oral Science
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