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Journal of Diabetes

Ann M Carracher, Payal H Marathe, Kelly L Close
More than 31,000 attendeesfrom around the world gathered in Barcelona, Spain for the 2017 European Society of Cardiology conference. In presentinga post-hoc analysis of the Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes(LEADER)(1) trial, Dr Neil Poulter (Imperial College London, UK) showedthat results are still positive, indicating cardioprotection, after adjusting for baseline history of stroke or myocardial infarction (MI), which had no mediating effect on the significant association between Novo Nordisk's (Copenhagen, Denmark) glucagon-like peptide-1 (GLP-1) agonist Victoza (liraglutide) and cardiovascular risk reduction...
September 15, 2017: Journal of Diabetes
Taeho Greg Rhee, Sarah M Westberg, Ila M Harris
OBJECTIVES: While complementary and alternative medicine (CAM) is increasingly used, little is known about reasons for CAM use (treatment, wellness or both) and self-reported perceived benefits among U.S. adults with diabetes at the national level. We estimated prevalence rates of overall and specific types of CAM by reason for use, and examined perceived benefits of using CAM by reason for use among U.S. adults with diabetes. METHODS: We used cross-sectional data from the 2012 National Health Interview Survey, which represents non-institutionalized adults with diabetes (n = 3,386 unweighted)...
September 12, 2017: Journal of Diabetes
Avivit Cahn, Amit Akirov, Itamar Raz
Diabetes care is largely dependent on patient self-management and empowerment, given that patients with diabetes must make numerous daily decisions of what to eat, when to exercise, and determine their insulin dose and timing if required. Additionally, patients and providers are generating vast amounts of data from many sources including electronic medical records, insulin pumps, sensors, glucometers, other wearables, as well as evolving genomic, proteomic, metabolomic and microbiomic data. Multiple digital tools and apps have been developed to assist patients to choose wisely, as well as enhance their compliance by employing motivational tools and incorporating incentives from social media and gaming techniques...
September 5, 2017: Journal of Diabetes
Xin Yin, Qi Liu, Jiate Wei, Xin Meng, Chongqi Jia
BACKGROUND: Only a few studies have investigated the effects of daytime napping on diabetes, and these studies have reported conflicting results. The current study aims to examine whether daytime napping is associated with a higher risk of prediabetes and diabetes. METHODS: This cross-sectional study of napping duration in relation to prediabetes and diabetes was conducted amongst 12,277 participants. Data from the first wave (2011) of the China Health and Retirement Longitudinal Study were used...
August 29, 2017: Journal of Diabetes
Yee Gary Ang, Chun Wei Yap, Xiao Bin Alex You
BACKGROUND: The mean annual direct medical cost of Type 2 Diabetes Mellitus (T2DM) in Singapore has been found to be SGD 2,034 using the prevalence-based approach but lifetime direct medical cost of T2DM in Singapore remains largely unknown. Our study aims to determine the lifetime direct medical cost attributed to T2DM and provide estimates of potential savings if T2DM can be prevented or delayed. METHODS: The incidence-based approach was used for our cost-of-illness analysis...
August 23, 2017: Journal of Diabetes
Ann M Carracher, Payal H Marathe, Kelly L Close
Diabetes educators from across the globe gathered in Indianapolis, IN, USA for the 2017 American Association of Diabetes Educators (AADE) conference. In a well-attended lecture on combination regimens for diabetes, Dr Kitte Wyne (Ohio State University, Columbus, OH, USA) advocated for the use of combination therapy according to AACE (American Association of Clinical Endocrinologists) treatment guidelines.
August 18, 2017: Journal of Diabetes
Muhammed Kizilgul, Joshua J Wilhelm, Gregory J Beilman, Srinath Chinnakotla, Ty B Dunn, Timothy L Pruett, Muhamad Abdulla, David Heller, Martin L Freeman, Sarah J Schwarzenberg, Bernhard J Hering, Melena D Bellin
BACKGROUND: Pancreatic fat might adversely affect beta-cell mass and function, possibly via the local release of non-esterified fatty acids (NE-FAs) and pro-inflammatory and vasoactive factors released by adipose tissue, however, the impact of intrapancreatic fat has never been studied in patients with pancreatitis undergoing total pancreatectomy with islet autotransplantation (TPIAT). We aimed to test whether pancreatic fatty infiltration has a negative effect on metabolic outcomes following TPIAT METHODS: We studied the association between pancreatic fatty infiltration and diabetes outcomes in 79 patients undergoing TPIAT with low (LPF; n = 53) or high (HPF; n = 26) pancreatic fat content...
August 10, 2017: Journal of Diabetes
Aihua Liu, Shuang Chen, Xiaofan Guo, Zhao Li, Liqiang Zheng, Yingxian Sun
Serum alanine aminotransferase (ALT) is a strong biomarker for liver fat accumulation and hepatic insulin sensitivity(1) . Previous studies have demonstrated that liver enzymes are predictors for incident diabetes(2) , but few of these studies were conducted in general Chinese population. One study, in an older urban cohort, did show such a relationship(3) .
August 10, 2017: Journal of Diabetes
Zachary T Bloomgarden
The diaTribe Foundation convened a meeting on the topic of discuss glycemic outcomes beyond A1C on July 21, 2017, in Bethesda, MD, focusing on potential uses of continuous glucose monitoring (CGM). Understanding patterns of glycemia in persons with diabetes has long been a focus of approaches to improving treatment ((2) ), and over the past few years this has become an available modality for clinical practice ((3) ). Glucose levels are not the only biologic parameters affecting A1c levels.
August 9, 2017: Journal of Diabetes
Abdur Razzaque Sarker, Marufa Sultana
In Bangladesh, the prevalence of non-communicable diseases (NCDs) has sharply increased in last few decades while diabetes is one of the alarming public health concern among all the NCDs. Approximately one-fifth of adult diabetes patient live in the Southeast Asian countries and it is predicted that Bangladesh will become the 8th highest diabetic populous country in the world within next 15 years.(1).
July 27, 2017: Journal of Diabetes
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 550 people gathered in Keystone, Colorado, USA for the 27th annual Practical Ways to Achieve Targets in Diabetes Care (ATDC) Conference. In a keynote lecture on the best of the American Diabetes Association's (ADA) 2017 Scientific Sessions, the organization's Chief Scientific, Medical, and Mission Officer Dr. William Cefalu summarized new data in the diabetes field.
July 24, 2017: Journal of Diabetes
Yiming Mu, Xiaomin Liu, Quanmin Li, Kangning Chen, Yu Liu, Xiaofeng Lv, Xiangjin Xu, Dongsheng Fan, Ningxiu Shang, Ruoyong Yang, Lynne Pauer, Changyu Pan
BACKGROUND: Limited information exists on the efficacy of pregabalin in Chinese patients with diabetic peripheral neuropathy (pDPN). METHODS: An 11-week, double-blind, placebo-controlled trial in Chinese pDPN patients randomized (1:1) to pregabalin 300 mg/day or placebo. Primary efficacy endpoint was change from baseline in mean daily pain score (0 = no pain;10 = worst possible pain). Secondary efficacy endpoints included overall weekly mean pain score, responder status, impression of change, pain intensity, and sleep...
July 20, 2017: Journal of Diabetes
Andrew Drexler
Two years ago, data presented at the Annual ADA meeting in New Orleans showed a dramatic decrease in deaths, especially those due to cardiovascular disease, with use of empagliflozin ((1) ). Two major questions have been asked: Was the result a fluke?, and Was it a class effect, or was it specific to the agent used? The hope that both questions would be answered by a second study has been answered. The conclusions of EMPA-REG were not an anomaly, and it is a class effect, not one caused by a specific drug.
July 10, 2017: Journal of Diabetes
Leili Gao, Yufeng Li, Dadong Fei, Li Ma, Shuchun Chen, Bo Feng, Qing Su, Linong Ji
BACKGROUND: To investigate the prevalence of diabetic ketosis (DK) and risk factors for it in Chinese diabetes patients with severe hyperglycemia. METHODS: This is a multicenter, cross-sectional study. Patients aged >16 years with diabetes mellitus and a random blood glucose level >13.9 mmol/L (>250 mg/dl) were recruited to the study. Blood ketones (β-hydroxybutyric acid) and urine ketones (acetoacetic acid) were measured and patients' demographic and clinical characteristics were collected...
July 7, 2017: Journal of Diabetes
Alina Scridon, Marcel Perian, Alina Mărginean, Adina Huțanu, Doina Gherțescu, Adriana Vântu, Paul Ciprian Fișcă, Philippe Chevalier, Răzvan Constantin Șerban, Dan Dobreanu
BACKGROUND: Dabigatran etexilate (DE) appears to ensure similar efficacy for stroke prevention in patients with and without diabetes mellitus (DM). However, the benefit of reducing major bleeding was not seen in diabetics. Thus, we aimed to investigate the anticoagulant response to DE and the biological predictors of this response using an experimental DM model. METHODS: Six control rats (C), 8 DE-treated controls (CD), 5 diabetics (D), and 8 DE-treated diabetics (DD) were investigated...
July 3, 2017: Journal of Diabetes
Jianping Weng
No abstract text is available yet for this article.
June 29, 2017: Journal of Diabetes
Payal H Marathe, Abigail E Dove, Kelly L Close
More than 16,000 people gathered in San Diego, CA, USA for the 77th annual Scientific Sessions of the American Diabetes Association (ADA). One of the most highly-anticipated sessions of the meeting was a presentation of integrated results from the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS and CANVAS-R) trials.(1) The program studied a total of 10,142 people across two trials.
June 28, 2017: Journal of Diabetes
Zachary Bloomgarden
The algorithms and guidelines of the American Association of Clinical Endocrinologists and the American Diabetes Association recommend that insulin administration be strongly considered for people with type 2 diabetes (T2D) with HbA1c levels exceeding 9.0% and 10%, respectively. Although the caveat is given in both sets of recommendations that this is particularly appropriate when patients are "symptomatic," referring to urinary frequency with increased thirst and appetite, weight loss, and ketosis, the clinical definition of such presentations may be ill-defined, and it is noteworthy that both documents consider insulin to offer particular benefit under such circumstances...
September 2017: Journal of Diabetes
Yong Kang Cheah, Kim-Leng Goh
No abstract text is available yet for this article.
September 2017: Journal of Diabetes
Abigail E Dove, Payal H Marathe, Helen X Gao, Kelly L Close
Abigail E. Dove, Payal H. Marathe, Helen X. Gao, and Kelly L. Close are of Close Concerns (, a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Dove, Marathe, Gao, and Close review the latest developments relevant to researchers and clinicians.
September 2017: Journal of Diabetes
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