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Journal of Diabetes

Bingyuan Wang, Ming Zhang, Yu Liu, Xizhuo Sun, Lu Zhang, Chongjian Wang, Li Linlin, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu
BACKGROUND: Inexpensive and easily measurable indexes are needed to predict type 2 diabetes mellitus (T2DM) early in rural areas of China. We aimed to compare triglyceride glucose (TyG), visceral adiposity (VAI), and lipid accumulation product (LAP) along with traditional individual measures and their ratios for predicting T2DM. METHODS: Data for 11,113 people with baseline normal fasting glucose in a rural Chinese cohort were followed for a median of 6.0 years...
January 11, 2018: Journal of Diabetes
Piotr Foltynski, Piotr Ladyzynski, Ewa Pankowska, Karolina Mazurczak
BACKGROUND: Patients using an insulin pump as part of their diabetes treatment need to calculate insulin bolus to compensate for a meal. Some patients do not modify their meal boluses according to the changing amount and composition of food products in a meal. The lack of correct meal boluses leads to unstable, and therefore harmful blood glucose levels. The aim of the current study was to test the system supporting bolus determination based on the voice description of a meal. METHODS: The developed bolus calculator consists of the smartphone application and three remote servers for automatic speech recognition, text analysis, and insulin dosage calculation...
January 8, 2018: Journal of Diabetes
Lin Ding, Yu Xu, Shanshan Liu, Yufang Bi, Yiping Xu
The prevalence of diabetes is increasing dramatically throughout the world, especially in China. Hemoglobin A1c (HbA1c) is an indicator of mean blood glucose concentrations and plays an important role in the assessment of glucose control and cardiovascular risk. In 2010 the American Diabetes Association (ADA) included HbA1c ≥6.5% into the revised criteria for the diagnosis of diabetes. However, the debate on whether HbA1c should be used to diagnose diabetes is far from being settled and there are still unanswered questions regarding the cutoff value of HbA1c for diabetes diagnosis in different populations and ethnicities...
January 2, 2018: Journal of Diabetes
Golaleh Asghari, Hossein Farhadnejad, Farshad Teymoori, Parvin Mirmiran, Maryam Tohidi, Fereidoun Azizi
BACKGROUND: The aim of this study was to investigate the association between branched-chain amino acids (BCAAs) intake and markers of insulin metabolism in adults. METHODS: This cohort study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS), on 1205 subjects, aged ≥ 20 years, who followed-up for a mean duration of 2.3 years. Dietary intakes of BCAAs including valine, leucine, and isoleucine were determined, using a valid and reliable food-frequency questionnaire...
December 27, 2017: Journal of Diabetes
Ryuichi Nakagawa, Kei Takasawa, Tzu-Wen Yeh, Kohsuke Imai, Kenichi Kashimada, Tomohiro Morio
Primary immunodeficiency (PID) is a disorder in which the immune system does not function normally1 . In addition to the increased risk of infection, autoimmune disorders are often observed in PID.1.
December 27, 2017: Journal of Diabetes
Ann M Carracher, Payal H Marathe, Kelly L Close
The American Heart Association's 2017 Scientific Sessions took place in November 2017 in Anaheim, CA, USA. Dr Kenneth Mahaffey (Stanford University, CA, USA) discussed a subgroup analysis1 of the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) trial,2 suggesting consistent heart failure and renal benefits to the sodium/glucose cotransporter 2 (SGLT-2) inhibitor Invokana (canagliflozin) across primary and secondary prevention cohorts.
December 26, 2017: Journal of Diabetes
Ying Zheng, Zhen Wang, Zhiguo Xie, Ruchun Dai, Zhiguang Zhou
Interferon therapy can increase the risk of type 1 diabetes (T1D) in patients with hepatitis C. Fulminant type 1 diabetes (FT1D) is a novel subtype of T1D characterized by extremely rapid progression1 . However, the relationship between interferon therapy and FT1D remains to be identified.
December 19, 2017: Journal of Diabetes
Nan Zhang, Xiang Hu, Tian Shu Zeng, Jiao-Yue Zhang, Sheng-Hua Tian, Jie Min, Han-Tao Huang, Juan Zheng, Xiuling Deng, Lu-Lu Chen
Diabetes mellitus, a major global challenge, caused death every 6 seconds in 2015. In the same year, 12% of global health expenditure was spent on diabetes.1 Preventing development of diabetes is a meaningful topic.
December 15, 2017: Journal of Diabetes
Wenying Yang, Jianhua Ma, Yiming Li, Yanbing Li, Zhiguang Zhou, Jae Hyeon Kim, June Zhao, Agata Ptaszynska
BACKGROUND: This 24-week, phase 3, double-blind, placebo-controlled study (NCT02096705) assessed the safety and efficacy of dapagliflozin as add-on to insulin ± oral antihyperglycemic drugs (OADs) in Asian patients with inadequately controlled type 2 diabetes. METHODS: Patients (adults; HbA1c ≥7.5-≤10.5%; body mass index ≤45 kg/m2 ; insulin dose ≥20 IU daily) were randomized to dapagliflozin 10 mg (N=139) or placebo (N=133) to assess the 24-week change in HbA1c (primary outcome), fasting plasma glucose (FPG), body weight, total daily dose of insulin (TDDI), and seated systolic blood pressure (SeSBP; exploratory outcome)...
December 7, 2017: Journal of Diabetes
Armando Arredondo, Alejandra Azar
The economic and social impact of diabetes, as pointed out by Hind A et al1 , is putting pressure on health systems and patients from low and middle-income countries (LMICs). The panorama to solve the demand for services of the population with diabetes in these countries is not encouraging.
December 5, 2017: Journal of Diabetes
Dongmei Wang, Yijie Liu, Suhuan Liu, Lin Lin, Changqin Liu, Xiulin Shi, Zheng Chen, Mingzhu Lin, Shuyu Yang, Zhibin Li, Li Xuejun
BACKGROUND: Laboratory studies found Fetuin-B impaired insulin action in myotubes and hepatocytes and caused glucose intolerance in mice. We aimed to explore the correlation of serum Fetuin-B with intrahepatic triglyceride (IHTG) content and the association of Fetuin-B with the risk of insulin resistance in general adults. METHODS: A cross-sectional study of 1,318 obese adults who underwent serum Fetuin-B test and hepatic ultrasonography scanning was conducted in Xiamen, China...
December 1, 2017: Journal of Diabetes
Mary A M Rogers, Paul Lin, Brahmajee K Nallamothu, Catherine Kim, Akbar K Waljee
BACKGROUND: We assessed the frequency of short-term oral corticosteroid use in adults with diabetes, and examined the incidence of fractures, venous thromboembolism (VTE) and hospitalization for sepsis after corticosteroid use. We also evaluated whether preventative medications mitigated adverse events. METHODS: We conducted a longitudinal study of 1,548,945 adults (ages 18-64 years) who received healthcare coverage through a large national health insurer, years 2012-2014...
November 28, 2017: Journal of Diabetes
Tao Wang, Jun Zhao, Jian Zhang, Jiacai Mei, Mingzhe Shao, Ye Pan, Wenchao Yang, Yujie Jiang, Fang Liu, Weiping Jia
BACKGROUND: Heparan sulfate attenuated inflammatory response and improve diabetic wound healing in rats. However, the specific mechanisms that heparan sulfate suppresses inflammation are not clear. Nucleotide binding oligomerization domin-like receptor family pyrin domain containing-3 (NLRP3) is a major receptor involved in innate immune regulation. The present study aimed to elucidate the effect of heparan sulfate on NLRP3 and pro-inflammatory cytokines in diabetic wound. METHODS: Full-thickness wounds were created on the back of diabetic rats...
November 24, 2017: Journal of Diabetes
Kui Peng, Yuhong Chen
We thank Tomoyuki Kawada for the comments(1) in response to our recent article in Journal of Diabetes titled 'Short sleep duration and longer daytime napping are associated with non-alcoholic fatty liver disease in Chinese adults', where we assessed the association between sleep habit and non-alcoholic fatty liver disease (NAFLD).(2).
November 22, 2017: Journal of Diabetes
Serena Low, Su Chi Lim, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Eng Kuang Lim, Yan Li Shao, Winnie Chui, Sharon Fun, Chin Lian Chua, Tavintharan Subramaniam, Chee Fang Sum
BACKGROUND: The best model of care to retard diabetic kidney disease (DKD) in the clinic is under-unexplored. We investigated the long-term renal outcomes of a joint endocrinologist-nephrologist clinic. METHODS: This was a nested case-control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care Diabetes Centre (DC). Cases ("DKD clinic group") are patients seen at the CKD clinic after being referred by physicians in DC for management of DKD...
November 20, 2017: Journal of Diabetes
Ann M Carracher, Payal H Marathe, Kelly L Close
The 20th annual Diabetes Canada Professional Conference took place in November 2017 in Edmonton, Alberta, Canada, featuring Dr Daniel Drucker on 30 years of incretin biology research and Dr David Matthews on implications of the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) trial,(1) among other sessions.
November 20, 2017: Journal of Diabetes
Stoyan Popkirov, Seena Sebastian, Fatme Seval Ismail, Jörg Wellmer
Antibodies against glutamic acid decarboxylase (GAD) are a hallmark of type 1 diabetes and its late-onset variant, latent autoimmune diabetes of the adult (LADA).(1) While cerebrovascular disease and dementia are common causes of cognitive dysfunction and neurological deficits in diabetic patients,(2,3) rare autoimmune disorders of the central nervous system such as stiff-person syndrom or limbic encephalits can also occur on the basis of shared GAD autoimmunity.(4,5).
November 20, 2017: Journal of Diabetes
Kui Peng, Gang Chen, Chao Liu, Yiming Mu, Zhen Ye, Lixin Shi, Jiajun Zhao, Lulu Chen, Qiang Li, Tao Yang, Li Yan, Qin Wan, Shengli Wu, Guixia Wang, Zuojie Luo, Xulei Tang, Yanan Huo, Zhengnan Gao, Qing Su, Youmin Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Yu Xu, Min Xu, Yuhong Chen, Jieli Lu, Lin Lin, Rui Du, Meng Dai, Mian Li, Tiange Wang, Zhiyun Zhao, Di Zhang, Yufang Bi, Donghui Li, Weiqing Wang, Guang Ning
BACKGROUND: A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the impact of active smoking and smoking cessation on glycemic control in patients with diabetes. We aimed to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients. METHODS: This is a cross-sectional study of 10,551 man and 15,297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study...
November 16, 2017: Journal of Diabetes
Zachary Bloomgarden, Yehuda Handelsman
A number of factors determine HbA1c other than the level of glucose exposure alone ((1) ). In analysis of 941 diabetic persons with varying degrees of chronic kidney disease (CKD), and 724 not having CKD, from a subset of the Atherosclerosis Risk in Communities studywith mean age in the eighth decade, Jung and coworkers ask whether HbA1c is reliable as an indicator of glycemia in persons with kidney disease (CKD) to the same degree as in those not having kidney disease, andif not whether measures of glycated serum proteins might be more useful...
November 10, 2017: Journal of Diabetes
Iuliia Azarova, Olga Bushueva, Alexander Konoplya, Alexey Polonikov
BACKGROUND: A compromised defense against reactive oxygen species (ROS) is considered to play an important role in the pathogenesis of type 2 diabetes (T2D), therefore, genes encoding antioxidant defense enzymes may contribute to disease susceptibility. The present study investigated whether polymorphisms in the genes encoding glutathione S-transferase M1 (GSTM1), T1 (GSTT1) and P1 (GSTP1) jointly contribute to the risk of T2D. METHODS: A total of 1,120 unrelated Russian subjects, including 600 patients with T2D and 520 age- and sex-matched healthy subjects, were recruited for this study...
November 7, 2017: Journal of Diabetes
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