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Journal of Diabetes

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https://www.readbyqxmd.com/read/29154443/long-term-outcomes-of-patients-with-type-2-diabetes-attending-a-multidisciplinary-diabetes-kidney-disease-clinic
#1
Serena Low, Su Chi Lim, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Eng Kuang Lim, Yan Li Shao, Winnie Chui, Sharon Fun, Chin Lian Chua, Tavintharan Subramaniam, Chee Fang Sum
BACKGROUND: The best model of care to retard diabetic kidney disease (DKD) in the clinic is under-unexplored. We investigated the long-term renal outcomes of a joint endocrinologist-nephrologist clinic. METHODS: This was a nested case-control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care Diabetes Centre (DC). Cases ("DKD clinic group") are patients seen at the CKD clinic after being referred by physicians in DC for management of DKD...
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29154404/diabetes-news
#2
Ann M Carracher, Payal H Marathe, Kelly L Close
The 20th annual Diabetes Canada Professional Conference took place in November 2017 in Edmonton, Alberta, Canada, featuring Dr Daniel Drucker on 30 years of incretin biology research and Dr David Matthews on implications of the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS) trial,(1) among other sessions.
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29154389/latent-autoimmune-diabetes-and-limbic-encephalitis-with-antibodies-against-glutamic-acid-decarboxylase
#3
Stoyan Popkirov, Seena Sebastian, Fatme Seval Ismail, Jörg Wellmer
Antibodies against glutamic acid decarboxylase (GAD) are a hallmark of type 1 diabetes and its late-onset variant, latent autoimmune diabetes of the adult (LADA).(1) While cerebrovascular disease and dementia are common causes of cognitive dysfunction and neurological deficits in diabetic patients,(2,3) rare autoimmune disorders of the central nervous system such as stiff-person syndrom or limbic encephalits can also occur on the basis of shared GAD autoimmunity.(4,5).
November 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29144059/association-between-smoking-and-glycemic-control-in-diabetic-patients-results-from-the-reaction-study
#4
Kui Peng, Gang Chen, Chao Liu, Yiming Mu, Zhen Ye, Lixin Shi, Jiajun Zhao, Lulu Chen, Qiang Li, Tao Yang, Li Yan, Qin Wan, Shengli Wu, Guixia Wang, Zuojie Luo, Xulei Tang, Yanan Huo, Zhengnan Gao, Qing Su, Youmin Wang, Guijun Qin, Huacong Deng, Xuefeng Yu, Feixia Shen, Li Chen, Liebin Zhao, Yu Xu, Min Xu, Yuhong Chen, Jieli Lu, Lin Lin, Rui Du, Meng Dai, Mian Li, Tiange Wang, Zhiyun Zhao, Di Zhang, Yufang Bi, Donghui Li, Weiqing Wang, Guang Ning
BACKGROUND: A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the impact of active smoking and smoking cessation on glycemic control in patients with diabetes. We aimed to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients. METHODS: This is a cross-sectional study of 10,551 man and 15,297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study...
November 16, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29124865/how-does-ckd-affect-hba1c
#5
EDITORIAL
Zachary Bloomgarden, Yehuda Handelsman
A number of factors determine HbA1c other than the level of glucose exposure alone ((1) ). In analysis of 941 diabetic persons with varying degrees of chronic kidney disease (CKD), and 724 not having CKD, from a subset of the Atherosclerosis Risk in Communities studywith mean age in the eighth decade, Jung and coworkers ask whether HbA1c is reliable as an indicator of glycemia in persons with kidney disease (CKD) to the same degree as in those not having kidney disease, andif not whether measures of glycated serum proteins might be more useful...
November 10, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29111615/glutathione-s-transferase-genes-and-the-risk-of-type-2-diabetes-mellitus-the-role-of-sexual-dimorphism-gene-gene-and-gene-smoking-interactions-in-disease-susceptibility
#6
Iuliia Azarova, Olga Bushueva, Alexander Konoplya, Alexey Polonikov
BACKGROUND: A compromised defense against reactive oxygen species (ROS) is considered to play an important role in the pathogenesis of type 2 diabetes (T2D), therefore, genes encoding antioxidant defense enzymes may contribute to disease susceptibility. The present study investigated whether polymorphisms in the genes encoding glutathione S-transferase M1 (GSTM1), T1 (GSTT1) and P1 (GSTP1) jointly contribute to the risk of T2D. METHODS: A total of 1,120 unrelated Russian subjects, including 600 patients with T2D and 520 age- and sex-matched healthy subjects, were recruited for this study...
November 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29091343/metabolic-memory-evolving-concepts
#7
EDITORIAL
Anoop Misra, Zachary Bloomgarden
The relationships of glycemic control over time with the development of complications have been investigated in several studies; but new areas of debate continue to arise. Does glycemic control have greater benefit when attained earlier than when attained later in the natural history of diabetes? Is it simply the duration of better or worse levels of glycemia that lead a given individual to have fewer or greater levels of complications? Might glycemic control have similar benefit throughout the duration of diabetes until irreversible damage occurs, perhaps varying by organ system (neurologic, renal, retinal, cardiovascular)...
November 1, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29072815/zinc-supplementation-in-pre-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Priyanga Ranasinghe, Wasundara Sevwandi Wathurapatha, Priyadarshani Galappatthy, Prasad Katulanda, Ranil Jayawardena, Godwin Roger Constantine
BACKGROUND: To evaluate the effects of Zinc supplementation on glycaemic control, other cadio-metabolic/anthropometric parameters and progression of disease in pre-diabetes. METHODS: The clinical trial was conducted as a randomized, double-blind, placebo-controlled Phase II clinical trial for a period of 12 months. The treatment group received Zinc (20mg daily). A total of 200 subjects with pre-diabetes were recruited for the study and randomly assigned into the treatment and control groups (1:1)...
October 26, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29072799/sleep-habits-and-non-alcoholic-fatty-liver-disease-risk-assessment-by-adjusting-confounders
#9
LETTER
Tomoyuki Kawada
Peng et al.(1) examined the associations between non-alcoholic fatty liver disease (NAFLD) and both nightly sleep duration and daytime napping in individuals aged ≥40 years. Sleep duration and the duration of daytime napping were self-reported and NAFLD was diagnosed by ultrasonography. The odds ratio of individuals with sleep duration <9 h for prevalent NAFLD significantly increased, which was predominant in individuals with sleep duration ≤6.1 h.
October 26, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29072367/reappraisal-of-metallothionein-clinical-implications-for-patients-with-diabetes-mellitus
#10
REVIEW
Yongsoo Park, Jian Zhang, Lu Cai
Reactive oxygen and nitrogen species (ROS/RNS) are by-products of cellular physiological processes made from the metabolisms of intermediary nutrients. Although physiological defense mechanisms readily convert these species into water or urea, improper balance between their production and removal leads cells to experience oxidative stress (OS), which is harmful to cellular components. This may result in uncontrolled growth or ultimately to cell death. ROS/RNS are also closely related to the development of diabetes and its complications...
October 26, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29055090/performance-of-nontraditional-hyperglycemia-biomarkers-by-chronic-kidney-disease-status-in-older-adults-with-diabetes-results-from-the-atherosclerosis-risk-in-communities-study
#11
Molly Jung, Bethany Warren, Morgan Grams, Yuenting Diana Kwong, Tariq Shafi, Josef Coresh, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: In persons with chronic kidney disease (CKD), hemoglobin A1c (HbA1c) may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. We investigated associations of HbA1c, glycated albumin, and fructosamine with fasting glucose by CKD categories. METHODS: Cross-sectional analysis of 1,665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes aged 65 years or older...
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29052971/diabetes-news
#12
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 15,000 attendees from more than130 countries gathered in Lisbon, Portugal for the 2017 European Association for the Study of Diabetes annual meeting. Dr Adrian Hernandez (Duke University, Durham, NC, USA) presented outcomes data from AstraZeneca's (Cambridge, UK) cardiovascular outcomes trial of GLP-1 agonist Bydureon (exenatide once weekly), Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL).(1).
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29031006/the-kidney-and-cvots
#13
EDITORIAL
Zachary Bloomgarden
Chronic kidney disease (CKD) affects a substantial minority of persons with type 2 diabetes. Analysis of US National Health and Nutrition Examination Survey (NHANES) datasets from 2007 through 2012 showed stage 3 or worse disease (estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m(2) ) in nearly one in five patients, with increasing age, blood pressure, obesity and levels of glycemia all associated with higher likelihood ((1) ), comparable to findings from surveys from many other areas, which also show micro- or macroalbuminuria to be present in one sixth to one third of diabetic persons ((2) )...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29031002/resistance-training-reduces-metabolic-syndrome-and-inflammatory-markers-in-older-women-a-randomized-controlled-trial
#14
Crisieli M Tomeleri, Mariana F Souza, Roberto C Burini, Cláudia R Cavaglieri, Alex S Ribeiro, Melissa Antunes, João P Nunes, Danielle Venturini, Décio S Barbosa, Luís B Sardinha, Edilson S Cyrino
BACKGROUND: There is controversial information regarding the effects of resistance training (RT) on the reduction of risk factors and metabolic syndrome (MetS)-related phenotypes, particularly, in older women. This study analyzed the effects of a 12-week RT program without dietary interventions on MetS components and inflammatory biomarkers in older women. METHODS: Fifty-three older women (70.4 ± 5.7 years; 26.7 ± 4.0 kg/m(2) ) were randomly assigned to a training group (TG, n = 26) that performed 12 weeks of RT program or a control group (CG, n = 27) that did not perform any type of physical exercise (same period)...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29030996/re-examining-the-sensitivity-of-glycated-hemoglobin-to-screen-for-diabetes-mellitus
#15
Chun Wei Yap, Yee Gary Ang, Timothy Peng Lim Quek, Bee Hoon Heng, Daniel Ek Kwang Chew
BACKGROUND: Glycated hemoglobin (HbA1c) is one of the laboratory tests recommended by the ADA to screen for diabetes mellitus (DM). It is particularly suitable for population segments that cannot or are unwilling to fast for a screening test. Our study aims to determine if HbA1c would be a useful tool to screen for DM in a real world setting if ADA guidelines for repeat testing to confirm the diagnosis of DM are strictly adhered to. METHODS: We carried out a retrospective database study by extracting demographic and laboratory data from a chronic disease registry which collects data on adults from three tertiary hospitals and nine large primary care clinics in Singapore...
October 14, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28976724/impact-of-glycemic-control-on-the-diabetes-complications-severity-index-score-and-development-of-complications-in-people-with-newly-diagnosed-type-2-diabetes
#16
Kevin M Pantalone, Anita D Misra-Hebert, Todd M Hobbs, Brian J Wells, Sheldon X Kong, Kevin Chagin, Tanujit Dey, Adam Milinovich, Wayne Weng, Janine M Bauman, Bartolome Burguera, Robert S Zimmerman, Michael W Kattan
AIMS: To assess the longitudinal accumulation of diabetes-related complications and the impact of glycemic control on the diabetes complications severity index (DCSI) score in people with newly-diagnosed type 2 diabetes (T2D). METHODS: A retrospective cohort study was conducted using electronic health records (EHR) from a large integrated healthcare system. People with newly-diagnosed T2D were identified between 2005-2016 and stratified by initial glycosylated hemoglobin (A1C) category (<7%, <8%, ≥8%)...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28976723/cost-effectiveness-of-prevention-and-management-of-diabetic-foot-ulcer-and-amputation-in-a-health-resource-limited-setting
#17
Bin Wu, Xu Wan, Jing Ma
BACKGROUND: To estimate the lifetime health and economic effects of different strategies of caring the diabetic foot in the Chinese setting. METHODS: A mathematical model was developed to simulate the onset and progression of diabetic foot disease in patients with type 2 diabetes managed with optimal care and usual care. Clinical and utility data were obtained from the published literature. Direct medical costs and resource utilization in the Chinese health care setting were considered...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28976079/pre-pregnancy-habitual-intake-of-vitamin-d-from-diet-and-supplements-in-relation-to-risk-of-gestational-diabetes-mellitus-a-prospective-cohort-study
#18
Wei Bao, Yiqing Song, Kimberly A Bertrand, Deirdre K Tobias, Sjurdur F Olsen, Jorge E Chavarro, James L Mills, Frank B Hu, Cuilin Zhang
BACKGROUND: Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the impact of vitamin D intake either from diet or from supplements on the development of gestational diabetes mellitus (GDM) remains unknown. We prospectively examined the association of pre-pregnancy habitual intake of vitamin D from diet and supplements with risk of incident GDM in a well-established cohort. METHODS: We included 21,356 singleton pregnancies from 15,225 women in the Nurses' Health Study II cohort...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28960806/regional-evidence-and-international-recommendations-to-guide-lipid-management-in-asian-patients-with-type-2-diabetes-with-special-reference-to-renal-dysfunction
#19
REVIEW
Titus Wl Lau, Kevin Ek Tan, Jason Cj Choo, T G Ng, Tavintharan S, Juliana C N Chan
The anticipated increase in the prevalence and incidence of type 2 diabetes in Asia, and its associated cardiovascular-renal complications will place a significant burden on patients, caregivers and society. Despite the proven effectiveness of lipid management in reducing these complications, there are major treatment gaps especially in Asian patients with young-onset diabetes and chronic kidney disease. Recent international guidelines recommended the adoption of absolute risk estimation of atherosclerosis and cardiovascular disease to guide treatment intensity...
September 28, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28940787/the-journal-of-diabetes-ushering-in-volume-10
#20
EDITORIAL
Zachary Bloomgarden, Guang Ning
As developments progress in the understanding and treatment of diabetes, we take a moment to reflect on the Journal as it enters its tenth year. It has been a decade of tremendous change. In 2009, the diabetes community was recovering from the shock of ACCORD trial : 257 deaths over 3.5 years with an achieved A1c of 6.4% among 5128 intensively treated the high cardiovascular risk patients, compared with 203 deaths with an achieved A1c of 7.5% among 5123 having "standard treatment"((1) ).
September 22, 2017: Journal of Diabetes
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