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Journal of Diabetes

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https://www.readbyqxmd.com/read/28749030/health-and-economic-burden-of-diabetes-in-bangladesh-attention-for-the-higher-priorities
#1
LETTER
Abdur Razzaque Sarker, Marufa Sultana
In Bangladesh, the prevalence of non-communicable diseases (NCDs) has sharply increased in last few decades while diabetes is one of the alarming public health concern among all the NCDs. Approximately one-fifth of adult diabetes patient live in the Southeast Asian countries and it is predicted that Bangladesh will become the 8th highest diabetic populous country in the world within next 15 years.(1).
July 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28737012/diabetes-news
#2
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 550 people gathered in Keystone, Colorado, USA for the 27th annual Practical Ways to Achieve Targets in Diabetes Care (ATDC) Conference. In a keynote lecture on the best of the American Diabetes Association's (ADA) 2017 Scientific Sessions, the organization's Chief Scientific, Medical, and Mission Officer Dr. William Cefalu summarized new data in the diabetes field.
July 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28727270/efficacy-and-safety-of-pregabalin-for-painful-diabetic-peripheral-neuropathy-in-a-population-of-chinese-patients-a-randomized-placebo-controlled-trial
#3
Yiming Mu, Xiaomin Liu, Quanmin Li, Kangning Chen, Yu Liu, Xiaofeng Lv, Xiangjin Xu, Dongsheng Fan, Ningxiu Shang, Ruoyong Yang, Lynne Pauer, Changyu Pan
BACKGROUND: Limited information exists on the efficacy of pregabalin in Chinese patients with diabetic peripheral neuropathy (pDPN). METHODS: An 11-week, double-blind, placebo-controlled trial in Chinese pDPN patients randomized (1:1) to pregabalin 300 mg/day or placebo. Primary efficacy endpoint was change from baseline in mean daily pain score (0 = no pain;10 = worst possible pain). Secondary efficacy endpoints included overall weekly mean pain score, responder status, impression of change, pain intensity, and sleep...
July 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28692750/can-we-go-beyond-surrogates
#4
EDITORIAL
Andrew Drexler
Two years ago, data presented at the Annual ADA meeting in New Orleans showed a dramatic decrease in deaths, especially those due to cardiovascular disease, with use of empagliflozin ((1) ). Two major questions have been asked: Was the result a fluke?, and Was it a class effect, or was it specific to the agent used? The hope that both questions would be answered by a second study has been answered. The conclusions of EMPA-REG were not an anomaly, and it is a class effect, not one caused by a specific drug.
July 10, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28685968/prevalence-of-and-risk-factors-for-diabetic-ketosis-in-chinese-diabetic-patients-with-a-random-blood-glucose-level-13-9-mmol-l-result-from-check-study
#5
Leili Gao, Yufeng Li, Dadong Fei, Li Ma, Shuchun Chen, Bo Feng, Qing Su, Linong Ji
BACKGROUND: To investigate the prevalence of diabetic ketosis (DK) and risk factors for it in Chinese diabetes patients with severe hyperglycemia. METHODS: This is a multicenter, cross-sectional study. Patients aged >16 years with diabetes mellitus and a random blood glucose level >13.9 mmol/L (>250 mg/dl) were recruited to the study. Blood ketones (β-hydroxybutyric acid) and urine ketones (acetoacetic acid) were measured and patients' demographic and clinical characteristics were collected...
July 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28671757/plasma-lipids-affect-dabigatran-etexilate-anticoagulation-in-rats-with-unbalanced-diabetes-mellitus
#6
Alina Scridon, Marcel Perian, Alina Mărginean, Adina Huțanu, Doina Gherțescu, Adriana Vântu, Paul Ciprian Fișcă, Philippe Chevalier, Răzvan Constantin Șerban, Dan Dobreanu
BACKGROUND: Dabigatran etexilate (DE) appears to ensure similar efficacy for stroke prevention in patients with and without diabetes mellitus (DM). However, the benefit of reducing major bleeding was not seen in diabetics. Thus, we aimed to investigate the anticoagulant response to DE and the biological predictors of this response using an experimental DM model. METHODS: Six control rats (C), 8 DE-treated controls (CD), 5 diabetics (D), and 8 DE-treated diabetics (DD) were investigated...
July 3, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28661564/short-term-intensive-insulin-therapy-could-be-the-preferred-option-for-new-onset-t2dm-patients-with-a1c%C3%A2-%C3%A2-9
#7
EDITORIAL
Jianping Weng
Type 2 diabetes mellitus (T2DM) is a heterogeneous disease. Currently, the typical clinical therapeutic pathway for the disease consists of the stepwise addition of anti-hyperglycemic preparations over time, followed lastly by insulin therapy when functional beta-cell capacity is severely deteriorated.
June 29, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28656725/diabetes-news
#8
Payal H Marathe, Abigail E Dove, Kelly L Close
More than 16,000 people gathered in San Diego, CA, USA for the 77th annual Scientific Sessions of the American Diabetes Association (ADA). One of the most highly-anticipated sessions of the meeting was a presentation of integrated results from the Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes (CANVAS and CANVAS-R) trials.(1) The program studied a total of 10,142 people across two trials.
June 28, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28640958/recommendations-for-revision-of-chinese-diagnostic-criterion-for-metabolic-syndrome-a-nationwide-study
#9
Ying Xing, Shaoyong Xu, Aihua Jia, Jing Cai, Mingwei Zhao, Jianhua Guo, Qiuhe Ji, Jie Ming
BACKGROUND: The metabolic syndrome (MS) criterion proposed by Chinese Diabetes Society (CDS) may have limitations, because it requires an additional 2-hour postprandial plasma glucose (2 h-PPG) to diagnose hyperglycemia. We aimed to revise the CDS criterion by removing the 2 h-PPG test, and determining the optimal fasting plasma glucose (FPG) cutoff for diagnosis of hyperglycemia in the Chinese population. METHODS: We obtained the study population from 2007-2008 China Diabetes and Metabolic Disorders Study...
June 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28609023/relations-of-sex-hormone-levels-to-leukocyte-telomere-length-in-black-hispanic-and-asian-pacific-islander-postmenopausal-women
#10
Yan Song, Michele Cho, Kathleen Brennan, Brian H Chen, Yiqing Song, JoAnn E Manson, Andrea L Hevener, Nai-Chieh Y You, Anthony W Butch, Simin Liu
BACKGROUND: Sex hormones may play important roles in sex-specific biological aging. We specifically examined the associations between circulating concentrations of sex hormones and leukocyte telomere length (TL). METHODS: We conducted a cross-sectional study of 1124 black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Concentrations of estradiol and testosterone were measured using electrochemiluminescence immunoassays...
June 13, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28589542/is-insulin-the-preferred-treatment-for-hba1c-9
#11
EDITORIAL
Zachary Bloomgarden
No abstract text is available yet for this article.
June 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28581207/improving-postprandial-hyperglycemia-in-patients-with-type-2-diabetes-already-on-basal-insulin-therapy-a-review-of-current-strategies
#12
REVIEW
Guillermo E Umpierrez, Timothy S Bailey, Danielle Carcia, Charles Shaefer, Jay H Shubrook, Neil Skolnik
A large number of patients with type 2 diabetes (T2D) on basal insulin do not reach their glycosylated hemoglobin A1c (HbA1c) goals and require additional therapy to address postprandial hyperglycemia. Guidelines from expert bodies have outlined several approaches to accomplish post-prandial glucose (PPG) control, and recent literature suggests several more. This article provides strategies for primary care physicians caring for patients with T2D who do not achieve glycemic control with basal insulin alone...
June 5, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544478/protective-role-of-physical-activity-on-type-2-diabetes-analysis-of-effect-modification-by-race-ethnicity
#13
William R Boyer, James R Churilla, Samantha F Ehrlich, Scott E Crouter, Lyndsey M Hornbuckle, Eugene C Fitzhugh
BACKGROUND: It is well known physical activity (PA) plays a role in the prevention of type 2 diabetes (T2D). However, the extent to which PA may affect T2D risk among different race-ethnic groups is unknown. Therefore, the aim of the present study was to systematically examine the effect modification of race-ethnicity on PA and T2D. METHODS: The PubMed and Embase databases were systematically searched through June 2016. Study assessment for inclusion was conducted in three phases: title review (n = 13 022), abstract review (n = 2200), and full text review (n = 265)...
May 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544369/american-association-of-clinical-endocrinologists-2017
#14
Abigail E Dove, Payal H Marathe, Helen X Gao, Kelly L Close
The 26th annual scientific and clinical sessions of the American Association of Clinical Endocrinologists (AACE) gathered in Austin, TX, USA from May 3-7, 2017. The meeting included little in the way of new data, but was rich in commentary from leaders in the diabetes field, particularly with regard to sodium/glucose cotransporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) agonists. In a deep-dive session on the renal effects of SGLT-2 inhibitors, both Dr Ralph DeFronzo and DrMatthew Weir were extremely positive about the renal benefit of these agents and expressed strong confidence that the benefits extend to all members of the class...
May 23, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544772/ganglioside-gm3-content-in-skeletal-muscles-is-increased-in-type-2-but-decreased-in-type-1-diabetes-rat-models-implications-of-glycosphingolipid-metabolism-in-pathophysiology-of-diabetes
#15
Josko Bozic, Anita Markotic, Vedrana Cikes-Culic, Anela Novak, Josip Andelo Borovac, Hrvoje Vucemilovic, Gorana Trgo, Tina Ticinovic Kurir
BACKGROUND: Ganglioside GM3 is an abundant constituent of the plasma membrane where its accumulation attenuates insulin receptor signaling. Considering the role of skeletal muscles for insulin-stimulated glucose uptake, the aim of this study was to determine the expression of GM3 and its precursors in skeletal muscle of diabetes mellitus type 1 (DM1) and type 2 (DM2) rat models. METHODS: Diabetes was induced by streptozotocin (55 mg/kg for DM1 and 35 mg/kg for DM2) injection to male Sprague-Dawley rats which were fed with normal pellet diet (DM1 type) or high-fat diet (DM2 type)...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544644/%C3%AE-cell-function-in-postmenopausal-women-with-isolated-post-challenge-hyperglycemia
#16
Chii-Min Hwu, Yi-Chun Lin, Kuan-Hung Lin
BACKGROUND: Isolated post-challenge hyperglycemia (IPH) is an early stage of type 2 diabetes mellitus (T2DM), with fasting glucose <126 mg/dL and 2-h glucose ≥200 mg/dL. Observations of insulin secretion profile in subjects with IPH may provide an insight into the pathogenesis of T2DM in older women. METHODS: We recruited 555 naturally postmenopausal women without a history of T2DM to the present study. All participants received a 75-g oral glucose tolerance test to determine whether they had IPH...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544548/assessment-of-factors-determining-an-hba1c-concentration%C3%A2-%C3%A2-%C3%A2-7-5-in-patients-with-type-1-diabetes
#17
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
BACKGROUND: Establishing an optimal insulin regimen is crucial for maintaining glycemic control in patients with type 1 diabetes. We aimed to determine the insulin dose required to achieve a hemoglobin A1c (HbA1c) concentration ≤ 7.5% in Japanese patients with type 1 diabetes. METHODS: This multi-centered cross-sectional study was performed at 3 institutions in Japan. Among 107 patients with type 1 diabetes, 92 had no detectable endogenous insulin secretion: 39 patients had HbA1c concentration ≤ 7...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544482/response-to-factors-affecting-blood-glucose-screening-in-the-elderly-with-special-reference-to-physical-activity
#18
LETTER
Yong Kang Cheah, Kim-Leng Goh
We appreciate greatly Kawada's(1) valuable comments on our recent publication that examined the factors affecting blood screening behaviour among the elderly.(2) Among others, socioeconomic and lifestyle factors were considered in our publication. Kawada(1) alluded to the findings of Cheah et al.(3) that participation in physical activity is determined by socioeconomic status, and Mosallanezhad et al.(4) that socioeconomic factors affect the health status of the elderly through mediation of physical activity...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28544429/diabetes-and-cardiometabolic-risk-factors-in-cambodia-results-from-two-screening-studies
#19
Julie Wagner, Diana Naranjo, Touch Khun, Serey Seng, Ien S Horn, Sakinah C Suttiratana, Lim Keuky
BACKGROUND: Despite growing attention to diabetes throughout Asia, data from Southeast Asia are limited. This article reports rates of diabetes, hypertension, and obesity in Cambodia. METHODS: Two studies were conducted across different regions of Cambodia: (i) a 2012 screening study across urban, semi-urban, and rural areas that used point-of-care capillary glucose for determination of diabetes (n = 13 997); and (ii) a 2005 epidemiological study with random selection from two main urban areas that used oral glucose tolerance tests for determination of diabetes (n = 1863)...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28523847/sex-differences-in-cardiovascular-risk-profiles-of-ischemic-stroke-patients-with-diabetes-in-the-greater-cincinnati-northern-kentucky-stroke-study
#20
Tracy E Madsen, Jane C Khoury, Kathleen A Alwell, Charles J Moomaw, Stacie L Demel, Matthew L Flaherty, Daniel Woo, Jason Mackey, Felipe De Los Rios La Rosa, Sharyl Martini, Simona Ferioli, Opeolu Adeoye, Pooja Khatri, Brett M Kissela, Dawn Kleindorfer
BACKGROUND: We aimed to compare sex-specific associations between cardiovascular risk factors and diabetes mellitus (DM) among patients with acute ischemic stroke (AIS) in the Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS). METHODS: The GCNKSS ascertained AIS cases in 2005 and 2010 among adult (age ≥20 years) residents of a biracial population of 1.3 million. Past and current stroke risk factors were compared between those with and without DM using chi-square and multiple logistic regression to examine sex-specific profiles...
May 18, 2017: Journal of Diabetes
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