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Journal of Diabetes

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https://www.readbyqxmd.com/read/28523847/sex-differences-in-cardiovascular-risk-profiles-of-ischemic-stroke-patients-with-diabetes-in-the-greater-cincinnati-northern-kentucky-stroke-study
#1
Tracy E Madsen, Jane C Khoury, Kathleen A Alwell, Charles J Moomaw, Stacie L Demel, Matthew L Flaherty, Daniel Woo, Jason Mackey, Felipe De Los Rios La Rosa, Sharyl Martini, Simona Ferioli, Opeolu Adeoye, Pooja Khatri, Brett M Kissela, Dawn Kleindorfer
BACKGROUND: We aimed to compare sex-specific associations between cardiovascular risk factors and diabetes mellitus (DM) among patients with acute ischemic stroke (AIS) in the Greater Cincinnati/Northern Kentucky Stroke Study (GCNKSS). METHODS: The GCNKSS ascertained AIS cases in 2005 and 2010 among adult (age ≥20 years) residents of a biracial population of 1.3 million. Past and current stroke risk factors were compared between those with and without DM using chi-square and multiple logistic regression to examine sex-specific profiles...
May 18, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28513098/nafld-and-t2d-the-importance-of-glycemic-control
#2
EDITORIAL
Zachary Bloomgarden
NAFLD is an important concern, as it can be identified in the majority of T2D persons and tracks with adverse outcome ((1,2) ). In the current issue of the Journal, Feng et al describe effects of liraglutide, gliclazide, and metformin in a well-characterized group of patients with poorly controlled type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD), whose HbA1c levels decreased from 8.9 to 5.9%, from 9.0 to 6.5%, and from 9.4 to 6.0%, respectively ((3) ). Intrahepatic fat decreased from baseline levels around 35% in all groups, by approximately 60% with liraglutide, significantly more than the decrease of approximately 30% with gliclazide, and the reduction in transaminase levels was only significant with liraglutide and with metformin...
May 16, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28449408/prediabetes-is-associated-with%C3%A2-genetic-variations-in-the-kir6-2-subunit%C3%A2-kcnj11-%C3%A2-of-pancreatic-atp-sensitive-potassium-channel-gene-a-case-control-study-in-youth-han-chinese-population
#3
Min Xu, Honglin Hu, Datong Deng, Mingwei Chen, Zhenshan Xu, Youmin Wang
BACKGROUND: E23K variant of the KCNJ11 has been reported to be associated with type 2 diabetes in multiple populations. However, little is known about the role of E23K polymorphism of the KCNJ11 in the development of prediabetes in youth in China. METHODS: To this end, we recruited 279 subjects with prediabetes and 240 normal controls. RESULTS: We found that prediabetic Chinese youth exhibited higher carrier rate of K23-allele-containing genotypes than control subjects (p = 0...
April 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28449335/factors-affecting-blood-glucose-screening-in-the-elderly-with-special-reference-to-physical-activity
#4
LETTER
Tomoyuki Kawada
I read with great interest the paper by Cheah et al.(1) The authors examined factors affecting participation of blood glucose screening among the elderly. They clarified that income, age, education, ethnicity, employment status, availability of medical coverage and smoking behavior were significantly associated with blood glucose screening. Physical activity is important for subjects with glucose intolerance,(2) and Cheah et al.(3) also clarified that physical activity was affected by several socio-economic factors...
April 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28436169/plasma-concentrations-of-lipids-during-pregnancy-and-the-risk-of-gestational-diabetes-mellitus-a-longitudinal-study
#5
Wei Bao, Sharon Dar, Yeyi Zhu, Jing Wu, Shristi Rawal, Shanshan Li, Natalie L Weir, Michael Y Tsai, Cuilin Zhang
BACKGROUND: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM), but studies with longitudinal measures of lipids throughout pregnancy are sparse. We aimed to characterize the longitudinal changes in lipid profiles throughout pregnancy and prospectively examine the associations of plasma lipid levels with risk of GDM. METHODS: This is a nested case-control study including 107 GDM cases and 214 matched non-GDM controls from participants in the NICHD Fetal Growth Studies-Singleton Cohort...
April 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28425181/effects-of-different-aerobic-exercise-frequencies-on%C3%A2-streptozotocin-nicotinamide-induced-type-2-diabetic-rats-continuous-versus-short-bouts-and-weekend-warrior-exercises
#6
Nuray Alaca, Serap Uslu, Guldal Gulec Suyen, Umit Ince, Mustafa Serteser, Hızır Kurtel
BACKGROUND: Exercise training is known to exert multiple beneficial effects on type 2 diabetes mellitus (T2DM). In this study, we aimed at exploring the effects of aerobic exercise frequencies on diabetic parameters, the histopathological structure of skeletal muscle, diabetic myopathy and mitochondrial enzyme activities in an experimental model of T2DM. METHODS: T2DM was induced by using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg) in Sprague Dawley rats (n: 35)...
April 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28425180/diabetes-news
#7
Payal H Marathe, Abigail E Dove, Helen X Gao, Kelly L Close
The 66th annual scientific sessions of the American College of Cardiology gathered thousands of attendees in Washington, DC, USA from March 17-19, 2017. The third and final day of the conference included a presentation of CVD-REAL results by Dr Mikhail Kosiborod (University of Missouri, MO, USA).
April 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28418203/effectiveness-of-vildagliptin-as-add-on-to-metformin-monotherapy-among-uncontrolled-type-2-diabetes-mellitus-patients-in-a-real-world-setting
#8
Cheli Melzer Cohen, Carla Davis, Varda Shalev, Gabriel Chodick
BACKGROUND: Vildagliptin is a dipeptidyl peptidase-4 inhibitor (DPP4-i) commonly used as a dual oral agent with metformin, thiazolidinediones, or sulfonylurea for type 2 diabetes mellitus (T2DM). The efficacy of dual therapy with vildagliptin and metformin has been established in randomized clinical trials but little evidence exists from observational studies. The aims of the present study were to evaluate the effectiveness of vildagliptin as an add-on therapy to metformin in reducing HbA1c as well as its influences on body weight and blood lipids in a real-life setting...
April 18, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28418191/evaluation-of-chinese-herbal-medicine-jinlida-in-type-2-diabetes-patients-based-on-stratification-results-of-subgroup-analysis-from-12-week-trial
#9
Jiaxing Tian, Fengmei Lian, Libo Yang, Xiaolin Tong
BACKGROUND: Previous study found that the Chinese Herbal Medicine Jinlida could significantly enhance the hypoglycemic action of metformin compared to metformin alone. However, the advantage of Jinlida has not been clarified yet. We aimed to compare the efficacy of Jinlida in patients with T2DM based on stratification. METHODS: Data were analyzed from a 12-week, randomized, placebo-controlled, double-blind, multicenter study of Jinlida. The efficacy evaluation included HbA1c, FPG and 2hPG levels stratified by baseline HbA1c, sex, age, BMI, and duration of DM diagnosis...
April 18, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28383185/interactions-between-general-and-central-obesity-in-predicting-gestational-diabetes-mellitus-in-chinese-pregnant-women-a-prospective-population-based-study-in-tianjin-china
#10
Qian Han, Ping Shao, Junhong Leng, Cuiping Zhang, Wei Li, Guifeng Liu, Yuanyuan Zhang, Yi Li, Zhe Li, Yanfeng Ren, Juliana Cn Chan, Xilin Yang
OBJECTIVE: To define cutoff points of body mass index and waist circumference for GDM and to check any additive interactions between high body mass index and high waist circumference for GDM in Chinese pregnant women. METHODS: From 2010 to 2012, we recruited 17,803 women who registered at 4 to12 weeks of gestation in Tianjin, China. GDM was diagnosed by the International Association of Diabetes and Pregnancy Study Group's criteria at 24 to 28 weeks of gestation...
April 6, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28374546/upper-extremity-arthropathy-in-diabetes
#11
EDITORIAL
Zachary Bloomgarden
Hou and coworkers used data analyzed nearly 60,000 persons with diabetes from the Taiwan National Health Insurance database in reporting a prevalence of 2.4% of diabetic hand syndrome, including carpal tunnel syndrome (in 1.2%), flexor tenosynovitis (also in 1.2%), and, much less frequently, limited joint mobility and Dupuytren's contracture.
April 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28371426/recovered-insulin-production-after-thiamine-administration-in-permanent-neonatal-diabetes-mellitus-with-a-novel-slc19a2-mutation
#12
Chengjun Sun, Zhou Pei, Miaoying Zhang, Bijun Sun, Lin Yang, Zhuhui Zhao, Ruoqian Cheng, Feihong Luo
BACKGROUND: SLC19A2 gene deficiency is one of the causes for permanent neonatal diabetes mellitus (PNDM) and it can be effectively managed by thiamine supplementation. We reported a male patient with novel SLC19A2 mutation and summarized the clinical characteristics of patients with SLC19A2 deficiency. METHODS: The genetic diagnosis of the patient with PNDM was made by sequencing and quantitative PCR. Clinical characteristics of the disease were summarized by systematic review of the literature...
March 30, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28332301/a-randomized-trial-comparing-gliclazide-liraglutide-and-metformin-effects-on-diabetes-with-nonalcoholic-fatty-liver-disease
#13
Wenhuan Feng, Caixia Gao, Yan Bi, Min Wu, Ping Li, Shanmei Shen, Wei Chen, Tingting Yin, Dalong Zhu
OBJECTIVE: To compare the effects of gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). METHODS: Eighty-seven subjects were randomized to receive liraglutide, metformin, or gliclazide for 24 weeks. Primary outcomes included hemoglobin A1c (HbA1c) levels, intrahepatic fat (IHF) content, and liver function. RESULTS: HbA1c levels and IHF content reduced after treatment in the three groups...
March 23, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28323393/evaluation-of-antidiabetic-activity-of-biologically-synthesized-silver-nanoparticles-agnps-using-pouteria-sapota-on-stz-induced-diabetic-rats
#14
Sathya Prabhu, Shanmugam Vinodhini, Chakravarthy Elenchezhiyan, Devi Rajeswari
BACKGROUND: Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be potent source effective agents in the treatment of diabetes mellitus. The present study is focused on the green synthesis of AgNPs from aqueous leaf extract of Pouteria sapota (P. sapota) in order to evaluate the in-vitro and in-vivo anti-diabetic property of aqueous extracts and their synthesized AgNPs. METHODS: AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P...
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28323390/diabetes-uk-professional-conference
#15
Payal H Marathe, Abigail E Dove, Helen X Gao, Kelly L Close
No abstract text is available yet for this article.
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28322508/the-influence-of-ampk-subunit-alpha-2-prkaa2-genetic-polymorphisms-with-susceptibility-with-type-2-diabetes-mellitus-and-diabetic-nephropathy-in-chinese-population
#16
Qingchu Li, Cuilin Li, Haoyun Li, Liu Zeng, Zhiqiang Kang, Yu Mao, Xinyue Tang, Panpan Zheng, Li He, Fang Luo, Zhi Li
BACKGROUND: It has been well recognized that the AMP-activated protein kinase (AMPK) is a key factor influencing the development of type 2 diabetes mellitus (T2DM). The single-nucleotide polymorphism (SNP) rs2746342 in AMPK α2 subunit gene (PRKAA2) has been found to be associated with the susceptibility to T2DM in the Chinese Han population recently. This study further investigates the association of PRKAA2 genotypes with the susceptibility to T2DM and its complication disease, diabetic nephropathy...
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28321990/diabetes-news
#17
Abigail E Dove, Brian J Levine, Payal H Marathe, Helen X Gao, Kelly L Close
Approximately 100 experts in diabetes gathered for the JDRF Mission Summit in San Francisco, CA, USA from January 26-27, 2017. The meeting focused on upcoming advances in type 1 diabetes therapy, and attendees discussed ways to encourage greater investment in type 1 diabetes research to produce next-generation options for treatment.
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28304147/relation-of-dietary-carbohydrates-intake-to-circulating-sex-hormone-binding-globulin-levels-in-postmenopausal-women
#18
Mengna Huang, Jinjie Liu, Xiaochen Lin, Atsushi Goto, Yiqing Song, Lesley F Tinker, Kei-Hang Katie Chan, Simin Liu
BACKGROUND: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relation between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. METHODS: Among postmenopausal women with available SHBG measurements at baseline (n = 11,159) in the Women's Health Initiative, we conducted a comprehensive assessment of total dietary carbohydrates, glycemic load (GL), glycemic index (GI), fiber, sugar, and various carbohydrate-abundant foods in relation to circulating SHBG using multiple linear regressions adjusting for potential covariates...
March 17, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28303680/serum-adipocyte-fatty-acid-binding-protein-levels-associate-with-peripheral-arterial-disease-in-women-not-in-men-with-type-2-diabetes
#19
Min Ding, Jian-Ying Shi, Yun-Zhi Xing, Bei Sun, Qian-Hua Fang, Jing-Yun Zhang, Qiu-Mei Zhang, Li-Ming Chen, De-Min Yu, Chun-Jun Li
BACKGROUNDS: Adipocyte fatty acid-binding protein (A-FABP) has been recognized an important player in macrophage cholesterol trafficking and inflammation, might promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between serum A-FABP levels and peripheral arterial disease (PAD) in patients with type 2 diabetes (T2DM). METHODS: A total of 488 inpatients with T2DM were enrolled in this study (254 men and 234 women, mean age, 57...
March 17, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28299899/salivary-gland-hypofunction-in-kk-ay-type-2-diabetic-mice
#20
Takashi Munemasa, Taro Mukaibo, Yusuke Kondo, Chihiro Masaki, Yuichiro Kusuda, Yuta Miyagi, Shintaro Tsuka, Ryuji Hosokawa, Tetsuji Nakamoto
BACKGROUND: Diabetes mellitus induces several hypofunctions in the body, including in the oral cavity. It is often associated with xerostomia, however the detailed underlying mechanism is not well characterized. METHODS: We used KK-Ay mice, a model of type 2 diabetes, to analyze the mechanism of diabetes-induced xerostomia with the ex vivo glandular perfusion technique, histological analysis, immunohistochemically and intracellular signaling analysis. RESULTS: Ex vivo submandibular gland secretions from KK-Ay mice decreased by 30% when stimulated with moderate stimulation of cholinergic agonist 0...
March 16, 2017: Journal of Diabetes
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