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Journal of Diabetes

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https://www.readbyqxmd.com/read/29774665/skin-autofluorescence-a-non-invasive-biomarker-for-advanced-glycation-end-products-is-not-related-to-the-number-of-pregnancies
#1
Robert P Van Waateringe, Laura Truyens, Paul P van den Berg, Helen L Lutgers, Bruce H R Wolffenbuttel
No abstract text is available yet for this article.
May 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29774661/what-does-the-acarbose-cardiovascular-evaluation-ace-trial-tell-us
#2
Rury R Holman
No abstract text is available yet for this article.
May 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29761666/prevalence-differentiations-of-periodontitis-by-diabetic-status-among-u-s-adults
#3
Ying Liu, Ronghai Bie, Laura R Iwasaki, Jeffrey C Nickel
Periodontal disease, a complication of diabetes mellitus (DM), may cause teeth loss and bone loss which is a major health-related threat for a large number of Americans. Lowering the prevalence of moderate and severe periodontitis is an objective of Healthy People 2020 in the US and a strategic plan of the U.S. Center for Disease Control and Prevention (CDC) for 2011-2014.1,2 This article is protected by copyright. All rights reserved.
May 14, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29749036/differential-mrna-expression-of-neuroinflammatory-modulators-in-the-spinal-cord-and-thalamus-of-type-2-diabetic-monkeys
#4
Huiping Ding, Norikazu Kiguchi, Shiroh Kishioka, Tao Ma, Christopher M Peters, Mei-Chuan Ko
BACKGROUND: Given that diabetes-associated complications are closely associated with neuroinflammation, it is imperative to study potential changes in neuroinflammatory modulators in the central nervous system of diabetic primates. METHODS: The mRNA levels of pro-inflammatory and anti-inflammatory cytokines, toll-like receptors (TLR), growth factors, and cannabinoid receptors were compared in the spinal dorsal horn (SDH) and thalamus of naturally occurring type 2 diabetic monkeys and an age-matched control group using reverse transcription and quantitative real-time polymerase chain reaction...
May 11, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29736976/antidiabetic-medication-de-escalation-following-bariatric-surgery
#5
Scott Martin Vouri, Jiajing Chen, Jayme Sparkman, Arghavan Salles, Scott T Micek
Approximately 216,000 bariatric surgery (BS) procedures were performed in 2016; an increase from 158,000 in 2011.1 This increase may be attributable to the rising awareness of beneficial effects on health and the improving safety profile of BS. According to the National Institutes of Health consensus criteria, patients qualify for bariatric surgery if they have a body mass index (BMI) ≥35 kg/m2 but <40 kg/m2 along with at least one obesity-related comorbidity or have a BMI ≥40 kg/m2 .
May 7, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29726111/clinical-usefulness-of-comprehensive-genetic-screening-in-mody-a-novel-abcc8-mutation-in-a-previously-screened-family
#6
Stephanie Robyn Johnson, Paul Leo, Louise Sonia Conwell, Mark Harris, Matthew Arthur Brown, Emma Letitia Duncan
Maturity-onset diabetes of the young (MODY) is the commonest form of monogenic diabetes, resulting from dominant mutations in one of fourteen genes that regulate beta-cell function (HNF4A, GCK, HNF1A, PDX1, HNF1B, NEUROD1, KLF11, CEL, PAX4, INS, BLK, ABCC8,KCNJ11 and APPL1 1,2 ). MODY accounts for 2-2.5% of childhood diabetes 3 , yet MODY genetic screening is uncommon, even in highly suggestive families, and when performed often limited to the commonest genes (e.g.HNF1A and GCK) 4 .
May 4, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29707905/human-herpes-virus-type-8-infection-dna-positivity-is-associated-with-low-insulin-secretion-a-case-control-study-in-a-sub-saharan-african-population-with-diabetes
#7
Eric Lontchi-Yimagou, Jérôme Legoff, Jean-Louis Nguewa, Philippe Boudou, Eric V Balti, Jean Jacques Noubiap, Vicky Kamwa, Barbara Atogho-Tiedeu, Marcel Azabji-Kenfack, Eric N Djahmeni, Martine Etoa, Gaelle Lemdjo, Vanessa Balla, Mesmin Y Dehayem, Fabienne Foufelle, Jean-Claude Mbanya, Jean-Francois Gautier, Eugene Sobngwi
BACKGROUND: Viruses have been considered as potential triggers for diabetes development. This study sought to assess insulin secretion and insulin sensitivity in Human Herpes Virus type 8 (HHV8) infected and non-infected sub-Saharan African people with diabetes. METHODS: We consecutively enrolled 173 people with non-autoimmune diabetes: 124 with type 2 diabetes (T2D), and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycaemic crisis. KPD was further sub-classified as new-onset ketotic phase KPD (n=34) or non-ketotic phase KPD (n=15)...
April 29, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29671962/glycemic-control-is-related-to-cognitive-dysfunction-in-chinese-children-with-type-1-diabetes-mellitus
#8
Jing He, Shichen Li, Fang Liu, Hong Zheng, Xiang Yan, Yuting Xie, Xia Li, Zhiguang Zhou, Xiongzhao Zhu
BACKGROUND: Type 1 diabetes mellitus (T1DM) type 1 diabetes is considered to be a risk factor for developing cognitive difficulties. The present study examined if Chinese children with T1DM differ in cognitive performance from healthy control (HC) children, and whether cognitive dysfunction is related to glycemic control. METHODS: Using a cross-sectional design, we administered cognitive tests, including general intelligence tests, to pediatric T1DM patients (N = 105) and HC participants (N = 90)...
April 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29671945/the-rs4686434-variant-in-the-fetub-locus-is-associated-with-intrahepatic-triglyceride-content-in-obese-chinese-adults
#9
Zhibin Li, Mingzhu Lin, Changqin Liu, Zheng Chen, Dongmei Wang, Xiulin Shi, Shuyu Yang, Xuejun Li
BACKGROUND: We aimed to explore associations of genetic variants in FETUB locus with intrahepatic triglyceride (IHTG) content. METHODS: We genotyped 4 tagging single-nucleotide polymorphisms (SNPs) of FETUB locus as well as PNPLA3 rs738409 and TM6SF2 rs58542926 in 418 obese Chinese adults who were measured on serum Fetuin-B and IHTG content. RESULTS: Subjects carrying the minor allele G for FETUB rs4686434 showed decreased serum Fetuin-B (AG/GG v...
April 19, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29665283/accelerated-executive-functions-decline-and-gray-matter-structural-changes-in-middle-aged-type-1-diabetes-patients-with-proliferative-retinopathy
#10
Eelco van Duinkerken, Martijn D Steenwijk, Martin Klein, Frederik Barkhof, Daniel C Mograbi, Michaela Diamant, Frank J Snoek, Richard G Ijzerman
BACKGROUND: The aim of this study was to determine trajectories of cognitive and cortical changes over time in middle-aged patients with type 1 diabetes and proliferative retinopathy. METHODS: Twenty-five patients and 25 controls underwent neuropsychological assessment and neuroimaging twice in 3.56 ± 0.65 and 3.94 ± 0.91 years respectively (P = 0.098). Cognitive assessment included the domains of general cognitive ability, memory, information processing speed, executive functions, attention, motor and psychomotor speed...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29664215/the-plasma-bile-acid-alterations-of-type-2-diabetes-correlated-with-insulin-secretion-in-two-step-hyperglycemic-clamp
#11
Shujie Wang, Yuying Deng, Xiaoyan Xie, Jing Ma, Min Xu, Xinjie Zhao, Weiqiong Gu, Jie Hong, Weiqing Wang, Guowang Xu, Guang Ning, Yanyun Gu, Yifei Zhang
BACKGROUND: Bile acids (BAs) conduct crucial signals in human metabolism. Correlations between human plasma BA alterations and insulin secretion defects and type 2 diabetes (T2D) progression have been insufficiently studied. This study was performed to explore the trajectories of human plasma BA alterations and their association with the insulin secretion dynamics during a two-step hyperglycemic clamp. METHODS: Eleven healthy (NGT) and 33 drug-naïve T2D subjects (T2Ds) were enrolled to undertake a two-step hyperglycemic clamp...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29658177/patterns-of-statin-use-and-long-term-adherence-and-persistence-among-older-adults-with-diabetes
#12
Richard Ofori-Asenso, Jenni Llomäki, Mark Tacey, Ella Zomer, Andrea J Curtis, J Simon Bell, Sophia Zoungas, Danny Liew
BACKGROUND: Statins reduce the risk of cardiovascular disease in patients with diabetes. We examined the prevalence of statin use and assessed the long-term adherence and persistence among people aged ≥65 years with diabetes. METHODS: Pharmaceutical Benefits Scheme data covering a 10% random sample of the Australian population were analysed. Among older adults with diabetes, the yearly prevalence of statin use was compared via Poisson regression modelling using 2006 as the reference year...
April 15, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29655268/acp-diabetes-guidelines-turn-back-the-clock-conflating-good-hba1c-with-hypoglycemia
#13
EDITORIAL
Zachary Bloomgarden, Daniel Einhorn, Yehuda Handelsman, Anoop Misra, Joel Zonszein, George Grunberger, Paul S Jellinger, Alan J Garber
The Clinical Guidelines Committee of the American College of Physicians (ACP) recently released the following Guidance Statements, "Clinicians should aim to achieve anHbA1c level between 7% and 8% in most patients with type 2diabetes," and "Clinicians should consider deintensifying pharmacologic therapy in patients with type 2 diabetes whoachieve HbA1c levels less than 6.5%"(1 ).
April 14, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29655199/transition-from-hospital-to-outpatient-diabetes-care
#14
EDITORIAL
Zachary Bloomgarden, Yehuda Handelsman
Diabetes affects ~9% of the US population, but accounts for 25% hospitalizations (1). Persons with diabetes have 40% higher 90-day rehospitalization rates than persons not having diabetes, with 30-day rehospitalization rates of 14.4-22.7%, 90-day rates above 26%, and 1-year rates of 30%, with evidence that there is a high-risk subset of ~10% of discharged persons with diabetes accounting for nearly two thirds of rehospitalizations (1). In a study of 124,967 persons age 50 or more hospitalized in California in 2006, 26...
April 14, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29633569/low-molecular-weight-fucoidan-protects-against-hindlimb-ischemic-injury-in-type-2-diabetic-mice-through-enhancing-endothelial-nitric-oxide-synthase-phosphorylation
#15
Tiantian Liu, Zhiqiang Wang, Xiaoping Chen, Hongjie You, Jingyi Xue, Dayong Cai, Yuanyuan Zheng, Yang Xu, Dali Luo
BACKGROUND: Diabetes mellitus (DM) complications are associated with vessel ischemic injury. Angiogenesis is a therapeutic strategy in the treatment of diabetic foot. Previous studies have suggested that low-molecular-weight fucoidan (LMWF) relaxed vessels through eNOS phosphorylation in diabetic rats. This study aims to investigate the possible angiogenic effect of LMWF in diabetic peripheral arterial disease (PAD). METHODS: Diabetic db/db mice and age-matched C57BL/6 mice were challenged with femoral artery ligation followed by LMWF or cilostazol treatment for 7 weeks...
April 6, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29633563/mild-hyperbaric-oxygen-inhibits-the-growth-related-decline-in-skeletal-muscle-oxidative-capacity-and-prevents-hyperglycemia-in-rats-with-type-2-diabetes
#16
Fumiko Nagatomo, Ai Takemura, Roland R Roy, Hidemi Fujino, Hiroyo Kondo, Akihiko Ishihara
BACKGROUND: Humans and animals with type 2 diabetes exhibit low skeletal muscle oxidative capacity and impaired glucose metabolism. The present study was designed to investigate the effects of exposure to mild hyperbaric oxygen on these changes in obese rats with type 2 diabetes. METHODS: Five-week-old nondiabetic Long-Evans Tokushima Otsuka (LETO) and diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats were divided into normobaric (LETO-NB and OLETF-NB) and mild hyperbaric oxygen (LETO-MHO and OLETF-MHO) groups...
April 6, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29604174/the-use-of-an-injection-port-is-helpful-in-improving-metabolic-control-and-compliance-to-a-strict-basal-bolus-regimen-in-children-and-adolescents-with-type-1-diabetes
#17
Giulio Maltoni, Maximiliano Zioutas, Stefano Zucchini, Andrea Pession
Basal-bolus regimen is the best treatment for children with type 1 diabetes (T1D), but requires several insulin injections a day1 . In fact, the body's physical growth, the management of frequent snacks and mistakes in carb-counting and in insulin boluses require the ability to promptly adapt insulin scheme2,3 .
March 31, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29577632/interleukin-2-receptor-antagonists-a-protective-factor-against-new-onset-diabetes-after-renal-transplantation
#18
Mengjuan Xue, Chenhe Zhao, Chaoyang Lv, Minling Chen, Ming Xu, Ruiming Rong, Yao Zhang, Jing Liang, Jian Gao, Mingxiang Yu, Tongyu Zhu, Xin Gao
BACKGROUND: The aim of the study was to examine the association between interleukin-2 receptor antagonists (IL-2Ra) and new-onset diabetes after transplantation (NODAT) among renal transplant recipients (RTRs). METHODS: Overall, 915 patients underwent renal transplantation between January 1993 and March 2014 at our hospital. A total of 557 RTRs were included in the present retrospective cohort study. The incidence of NODAT in this cohort was collected. Multivariate cox regression analysis was used to evaluate the risk factors of NODAT and show the association between IL-2Ra use and NODAT development among RTRs...
March 25, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29573578/associations-of-sleep-duration-and-prediabetes-prevalence-in-a-middle-aged-and-elderly-chinese-population-with-regard-to-age-and-hypertension-the-china-health-and-retirement-longitudinal-study-baseline-survey
#19
Mingming Yan, Zhen Fu, Tingting Qin, Nanjin Wu, Yalan Lv, Qinyun Wei, Hongwei Jiang, Ping Yin
BACKGROUND: The aim of the present study was to examine the age-specific associations between self-reported sleep duration and prevalent prediabetes in middle-aged and elderly Chinese with or without hypertension. METHODS: In all, 2985 Chinese adults aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS) baseline survey were selected for analysis. Sleep duration was assessed by structured questionnaires and then categorized into three groups (≤6, 6-8, and >8 h)...
March 24, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29573171/diabetes-news
#20
Ann M Carracher, Payal H Marathe, Kelly L Close
More than 2,000 attendees gathered in Vienna, Austria in mid-February for the 11th annual Advanced Technologies and Treatments for Diabetes (ATTD) meeting. There, Dr David Klonoff presented results from Novo Nordisk's (Copenhagen, Denmark) Onset 5 study of Fiasp (faster-acting insulin aspart) vs. NovoLog (insulin aspart) in pump users. In adults with type 1 diabetes on a pump (n=472), HbA1c-lowering was non-inferior for Fiasp compared to NovoLog, dropping from a baseline 7.5% to 7.44% with Fiasp and from the same baseline to 7...
March 23, 2018: Journal of Diabetes
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