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Journal of Diabetes

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https://www.readbyqxmd.com/read/28323393/evaluation-of-antidiabetic-activity-of-biologically-synthesized-silver-nanoparticles-agnps-using-pouteria-sapota-on-stz-induced-diabetic-rats
#1
Sathya Prabhu, Shanmugam Vinodhini, Chakravarthy Elenchezhiyan, Devi Rajeswari
BACKGROUND: Medicinal plants and green synthesis of silver nanoparticles (AgNPs) have proven to be potent source effective agents in the treatment of diabetes mellitus. The present study is focused on the green synthesis of AgNPs from aqueous leaf extract of Pouteria sapota (P. sapota) in order to evaluate the in-vitro and in-vivo anti-diabetic property of aqueous extracts and their synthesized AgNPs. METHODS: AgNPs were biologically synthesized under ambient conditions from an aqueous leaf extract of P...
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28323390/diabetes-uk-professional-conference
#2
Payal H Marathe, Abigail E Dove, Helen X Gao, Kelly L Close
More than 2,500 people, including renowned diabetes thought leaders from around the world, gathered in Manchester, UK from March 8-10 for the annual Diabetes UK professional conference. Dr. John Petrie (University of Glasgow, Glasgow, UK) presented full renal data from theLiraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial(1) of Novo Nordisk's (Bagsvaerd, Denmark) GLP-1 agonist Victoza (liraglutide).
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28322508/the-influence-of-ampk-subunit-alpha-2-prkaa2-genetic-polymorphisms-with-susceptibility-with-type-2-diabetes-mellitus-and-diabetic-nephropathy-in-chinese-population
#3
Qingchu Li, Cuilin Li, Haoyun Li, Liu Zeng, Zhiqiang Kang, Yu Mao, Xinyue Tang, Panpan Zheng, Li He, Fang Luo, Zhi Li
BACKGROUND: It has been well recognized that the AMP-activated protein kinase (AMPK) is a key factor influencing the development of type 2 diabetes mellitus (T2DM). The single-nucleotide polymorphism (SNP) rs2746342 in AMPK α2 subunit gene (PRKAA2) has been found to be associated with the susceptibility to T2DM in the Chinese Han population recently. This study further investigates the association of PRKAA2 genotypes with the susceptibility to T2DM and its complication disease, diabetic nephropathy...
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28321990/diabetes-news
#4
Abigail E Dove, Brian J Levine, Payal H Marathe, Helen X Gao, Kelly L Close
Approximately 100 experts in diabetes gathered for the JDRF Mission Summit in San Francisco, CA, USA from January 26-27, 2017. The meeting focused on upcoming advances in type 1 diabetes therapy, and attendees discussed ways to encourage greater investment in type 1 diabetes research to produce next-generation options for treatment.
March 21, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28304147/relation-of-dietary-carbohydrates-intake-to-circulating-sex-hormone-binding-globulin-levels-in-postmenopausal-women
#5
Mengna Huang, Jinjie Liu, Xiaochen Lin, Atsushi Goto, Yiqing Song, Lesley F Tinker, Kei-Hang Katie Chan, Simin Liu
BACKGROUND: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relation between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. METHODS: Among postmenopausal women with available SHBG measurements at baseline (n = 11,159) in the Women's Health Initiative, we conducted a comprehensive assessment of total dietary carbohydrates, glycemic load (GL), glycemic index (GI), fiber, sugar, and various carbohydrate-abundant foods in relation to circulating SHBG using multiple linear regressions adjusting for potential covariates...
March 17, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28303680/serum-adipocyte-fatty-acid-binding-protein-levels-associate-with-peripheral-arterial-disease-in-women-not-in-men-with-type-2-diabetes
#6
Min Ding, Jian-Ying Shi, Yun-Zhi Xing, Bei Sun, Qian-Hua Fang, Jing-Yun Zhang, Qiu-Mei Zhang, Li-Ming Chen, De-Min Yu, Chun-Jun Li
BACKGROUNDS: Adipocyte fatty acid-binding protein (A-FABP) has been recognized an important player in macrophage cholesterol trafficking and inflammation, might promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between serum A-FABP levels and peripheral arterial disease (PAD) in patients with type 2 diabetes (T2DM). METHODS: A total of 488 inpatients with T2DM were enrolled in this study (254 men and 234 women, mean age, 57...
March 17, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28299899/salivary-gland-hypofunction-in-kk-ay-type-2-diabetic-mice
#7
Takashi Munemasa, Taro Mukaibo, Yusuke Kondo, Chihiro Masaki, Yuichiro Kusuda, Yuta Miyagi, Shintaro Tsuka, Ryuji Hosokawa, Tetsuji Nakamoto
BACKGROUND: Diabetes mellitus induces several hypofunctions in the body, including in the oral cavity. It is often associated with xerostomia, however the detailed underlying mechanism is not well characterized. METHODS: We used KK-Ay mice, a model of type 2 diabetes, to analyze the mechanism of diabetes-induced xerostomia with the ex vivo glandular perfusion technique, histological analysis, immunohistochemically and intracellular signaling analysis. RESULTS: Ex vivo submandibular gland secretions from KK-Ay mice decreased by 30% when stimulated with moderate stimulation of cholinergic agonist 0...
March 16, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28276164/diabetes-and-tuberculosis-an-important-relationship
#8
EDITORIAL
Zachary T Bloomgarden, Anoop Misra
No abstract text is available yet for this article.
March 9, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28266136/the-effects-of-dipeptidyl-peptidase-4-inhibitors-in-type-2-diabetic-patients-with-moderate-to-severe-chronic-kidney-disease-meta-analysis-of-randomized-controlled-trials-by-using-unadjusted-data
#9
Man Yang, Ling Wang, Lijie Gu, Weijie Yuan
BACKGROUND: Three meta-analyses evaluated the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetic patients with chronic kidney disease (CKD) recently. However, direct combination of adjusted and unadjusted data in these meta-analyses, which may be questionable. The present study aimed to perform a meta-analysis of the effects of DPP-4 inhibitors in type 2 diabetic patients with moderate to severe CKD, by using unadjusted data from randomized controlled trials (RCTs)...
March 7, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28256079/response-to-untreated-sleep-apnea-syndrome-and-glycemic-control-in-patients-with-type-2-diabetes
#10
LETTER
Adriana Rusu, Cornelia Gabriela Bala, Gabriela Roman
No abstract text is available yet for this article.
March 3, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28256058/sex-and-age-discrepancy-of-hemoglobin-a1c-and-fetal-hemoglobin-by-hplc-in-a-large-chinese-han-population
#11
Jihong Hu, Jun Gao, Jianbo Li
BACKGROUND: Glycosylate Hemoglobin A1c (HbA1c) is an effective indicator to evaluate glycemic control. Fetal hemoglobin (HbF) is seldom been measured because traditional detection is inconvenient. In this regard, HbA1c analyzer may provide an advantage using high-pressure liquid chromatography (HPLC) automatically for HbF. The aim of this investigation was to explore HbA1c and HbF distribution features in a large Chinese Han population. METHODS: A total of 70553 laboratorial samples were collected from January 2012 to June 2016...
March 2, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#12
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28233459/vitamin-d-supplementation-improves-simvastatin-mediated-decline-in-exercise-performance-a-randomized-double-blind-placebo-controlled-study
#13
Mandeep Singla, Ashu Rastogi, Ashutosh Nath Aggarwal, Owais Mohammad Bhat, Darshan Badal, Anil Bhansali
BACKGROUND: The aim of the present study was to determine the effect of vitamin D supplementation on simvastatin-mediated changes in cardiorespiratory fitness and skeletal muscle mitochondrial content after exercise in adults with type 2 diabetes mellitus (T2DM). METHODS: Vitamin D deficient T2DM patients aged 25-50 years performed moderate intensity aerobic exercise for 12 weeks and were randomized to receive simvastatin 40 mg daily, simvastatin 40 mg daily and vitamin D 60,000 units once weekly, or vitamin D 60,000 units once weekly...
February 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28233424/predictive-factors-of-primary-and-secondary-sulfonylurea-failure-in-type-2-diabetic-subjects
#14
Huaiqing Wang, Qian Ren, Xueyao Han, Jing Chen, Lingli Zhou, Yingli Chen, Linong Ji
BACKGROUND: To investigate the value of clinical characteristics in predicting sulfonylurea treatment responses. METHODS: All the 747 subjects were from the Xiaoke Pill Clinical Trial evaluating safety and efficacy of sulfonylurea. They had the same initial dose of glibenclamide and drug doses were adjusted every 4 weeks during 48 weeks follow up. Primary sulfonylurea failure was defined as a less than 10% reduction of fasting plasma glucose (FPG) at the end of week 4 from randomization, whereas secondary sulfonylurea failure was defined as a consecutive confirmed level of FPG of more than 7 mmol/L...
February 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28224724/economic-and-social-impact-of-diabetes-mellitus-in-a-low-income-country-a-case-control-study-in-sudan
#15
Hind Elrayah-Eliadarous, Claes-Göran Östensson, Mohamed Eltom, Pia Johansson, Vibeke Sparring, Rolf Wahlström
AIMS: Diabetes mellitus accounts for 11% of total health expenditures worldwide, and the majority of all persons with diabetes live in low- and middle-income countries. This study examined the economic and social impact attributed to diabetes in Sudan by calculating out-of-pocket medical expenditures and the health and social impact of the disease for persons with diabetes (n = 375) and their families, compared to a non-diabetic control group (n = 375), matched for age, sex and residence area...
February 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28220624/cardio-protective-effects-of-pectin-insulin-patch-in-streptozotocin-induced-diabetic-rats-beneficial-effects-of-insulin-patch
#16
Ntethelelo Sibiya, Phikelelani Ngubane, Musa Mabandla
PURPOSE: Cardiovascular complications are amongst the leading causes of morbidity and mortality in diabetes mellitus. Despite the beneficial effects of subcutaneous insulin administration, reports suggest that the therapy itself precipitates cardiovascular risks due to the high insulin concentration administered. It is therefore necessary to seek alternative insulin administration routes that may bypass the undesirable effects associated with high plasma insulin concentration. Accordingly, the study investigated the effect of a novel transdermal pectin-insulin patch on selected cardiovascular function markers in diabetes...
February 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28220621/a-low-prevalence-of-non-alcoholic-fatty-liver-disease-in-patients-with-type-1-diabetes-is-associated-to-decreased-subclinical-cardiovascular-disease
#17
Enric Serra-Planas, Eva Aguilera, Laura Castro, Raúl Rodríguez, Isabel Salinas, Anna Lucas, Clara Joaquín, Rocio Puig, Dídac Mauricio, Manel Puig-Domingo
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD). METHODS: Cross-sectional study in which 100 T1D patients (39.4 ± 7.8 years, 54% male, all Caucasian, disease duration 21.7 ± 8.6 years, HbA1c 8.1 ± 1.0 % (64.2 ± 7...
February 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28218817/untreated-sleep-apnea-syndrome-and-glycemic-control-in-patients-with-type-2-diabetes
#18
LETTER
Tomoyuki Kawada
No abstract text is available yet for this article.
February 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28177592/predictors-of-type-1-diabetes-mellitus-outcomes-in-young-adults-after-transition-from-pediatric-care
#19
Alassaf Abeer, Gharaibeh Lubna, Grant Christina, Punthakee Zubin
BACKGROUND: Type 1 diabetes is a common chronic disease. Poor health outcomes are often noted after transfer to adult health care. It is important to determine the predictors of such outcomes to decrease the morbidity and mortality. METHODS: This retrospective study included patients followed ≥1year pre-transfer and ≥1 year post-transfer to adult care in a Canadian tertiary diabetes center. Data including demographics, education, comorbidity and pediatric diabetes management-related factors were analyzed as possible independent predictors of adult HbA1c, number of adult diabetes-related hospitalization and clinic visits...
February 8, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28150438/response-to-kawada-anxiety-symptoms-and-functioning-in-patients-with-type-2-diabetes
#20
LETTER
Sonya S Deschênes, Rachel J Burns, Norbert Schmitz
No abstract text is available yet for this article.
February 2, 2017: Journal of Diabetes
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