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Journal of Diabetes

Zachary Bloomgarden, Guang Ning
No abstract text is available yet for this article.
December 1, 2016: Journal of Diabetes
Chun-Ping Zeng, Yuan-Cheng Chen, Xu Lin, Jonathan Greenbaum, You-Ping Chen, Cheng Peng, Xia-Fang Wang, Rou Zhou, Wei-Min Deng, Jie Shen, Hong-Wen Deng
BACKGROUND: Clinical and epidemiological findings point to an association between type 2 diabetes (T2D) and low birth weight (BW). However, the nature underlying their relationship is largely unknown. Here, we aim to identify novel single-nucleotide polymorphisms (SNPs) in T2D, BW and their pleiotropic loci. METHODS: We applied a pleiotropy-informed conditional false discovery rate (cFDR) method to two independent GWAS summary statistics of T2D (n = 149,821) and BW (n = 26,836)...
November 29, 2016: Journal of Diabetes
Payal H Marathe, Abigail E Dove, Helen X Gao, Sarah A Odeh, Kelly L Close
No abstract text is available yet for this article.
November 24, 2016: Journal of Diabetes
Hamzeh Abunab, Wireen Leila Dator, Sana Hawamdeh
BACKGROUND: This systematic review statistically analyzed Randomized Controlled Trials on Olive Leaf Extract (OLE) for effectiveness in managing glucose levels in diabetic rats. METHODS: Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Comprehensive-Meta-analysis version 3.0 was used for data analysis. Findings from 8 trials that included 162 rats were reviewed...
November 17, 2016: Journal of Diabetes
Jun-Li Liu, Nancy Kaddour, Subrata Chowdhury, Qing Li, Zu-Hua Gao
In search of direct targets of IGF-I action, we discovered CCN5/WISP2 as a novel protein expressed in pancreatic β-cells. As a member of Cyr61 (connective tissue growth factor in human), CTGF (cysteine rich 61, in mouse), and Nov (nephroblastoma overexpressed, in chicken) family, IGF-I together with Wnt signaling stimulate its expression. When overexpressed in insulinoma cells, CCN5 promotes cell proliferation and cell survival against streptozotocin-induced cell death. The cell proliferation effect seems to be caused by AKT phosphorylation and increased cyclin D1 level...
November 12, 2016: Journal of Diabetes
Haixia Yang, Lei Xiao, Nanping Wang
Peroxisome proliferator-activated receptor alpha (PPARα) plays a key role in lipid metabolism and glucose homeostasis. It plays a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen PPARα ligands and modulators in our diet. In this review, we discuss recent advances involving PPARα, including its structure and function, ligand and modulator screening assays, and summarize the different types of PPARα ligands and modulators in the diet...
November 10, 2016: Journal of Diabetes
Jiung-Pang Huang, Mei-Ling Cheng, Cheng-Yu Hung, Chao-Hung Wang, Po-Shiuan Hsieh, Ming-Shi Shiao, Jan-Kan Chen, Dai-Er Li, Li-Man Hung
BACKGROUND: We compared the insulin resistance and metabolic alterations by using a global lipidomic approach. METHODS: Rats were fed with high-fat-diet (HFD) and high-fructose-diet (HFr) for 12 weeks to induced insulin resistance syndrome. RESULTS: Rats on both diets developed of insulin resistance syndrome, characterized by hypertension, hyperlipidemia, hyperinsulinemia, impaired fasting glucose, and insulin resistance. Compared with HFr rats, nonesterified-fatty-acid was lower, and body weight and plasma insulin level were markedly higher in the HFD animals...
November 8, 2016: Journal of Diabetes
Schimming Corbett, Luo Xiaodong, Zhang Cen, Sano Mary
BACKGROUND: Diabetes mellitus is a risk factor for cognitive changes, but assessment for cognitive disorders in this population is performed infrequently. This study examines the frequency of cognitive disorders and patterns of deficit in patients enrolled in a specialized clinic for diabetes. METHODS: A cross-sectional study was conducted to assess cognition in Mount Sinai Diabetes Center patients. Thirty eligible subjects age 50 or older were assessed and compared with non-diabetic cognitively normal control subjects, as well as non-diabetic subjects with Mild Cognitive Impairment (MCI)...
November 3, 2016: Journal of Diabetes
Steven T Yen, Andrew K G Tan, Mustapha I Feisul
BACKGROUND: Policy interventions of cardiovascular diseases require individual awareness of ailments. Such awareness is also key to changes by individuals in lifestyle and dietary habits. This study investigates the association of socio-demographic and health-lifestyle factors with awareness and prevalence of three ailments: diabetes, hypertension, and hypercholesterolemia. METHODS: Data are obtained from the Malaysia Non-Communicable Disease Surveillance-1. Logistic regressions are estimated and odds ratios of exposure variables calculated...
November 1, 2016: Journal of Diabetes
Lu Lu Jing, Wei Chen, Zi Lin Sun, Sai Nan Zhu, Li Shen, Wen Xia Li, Jin Huang, Qing Qing Lou, Rong Wen Bian, Xiao Hui Guo
BACKGROUND: The study was aimed to investigate knowledge, attitude, and practice (KAP) associated with Medical Nutrition Therapy (MNT) among Chinese adult patients with diabetes and pre-diabetes. METHODS: From May to August 2014, a cross-sectional study was conducted in 40 hospitals across China. KAP of the respondents was investigated through a pre-tested structured questionnaire in face-to-face interviews. Anthropometric and biochemical indicators were collected, and the KAP score was recorded according to patients' responses...
October 27, 2016: Journal of Diabetes
Hagit Shapiro, Jotham Suez, Eran Elinav
Personalized or precision medicine is a novel clinical approach targeted to the individual patient and based on integration of clinical, genetic and environmental factors that define a patient uniquely from other individuals featuring similar clinical symptoms. Such personalized medicine approach is increasingly applied for diagnosis, clinical stratification and treatment of the metabolic syndrome (MetS) associated risks and diseases, including obesity, type II diabetes, non-alcoholic fatty liver disease and their complications...
October 27, 2016: Journal of Diabetes
Xiaofei Lv, Weiwei Zhou, Jichao Sun, Ruhai Lin, Lin Ding, Min Xu, Yu Xu, Zhiyun Zhao, Yuhong Chen, Yufang Bi, Jieli Lu, Weiqing Wang, Guang Ning
BACKGROUND: Previous studies suggest that visceral fat is associated with type 2 diabetes (T2D) independent of body mass index (BMI). However, epidemiological data about the relationship between visceral fat and T2D are rare in Chinese. The aim of the present study was to investigate whether visceral fat area (VFA) is associated with T2D beyond and above BMI in the Chinese population. METHODS: The present community-based cross-sectional study was conducted in 2013 on 4126 individuals (2545 women, 1581 men) aged ≥ 40 years, with T2D diagnosed according to 1999 World Health Organization criteria...
October 27, 2016: Journal of Diabetes
Charlotte E Vollenbrock, Robert P Van Waateringe, Henk J Veeze, Henk-Jan Aanstoot, Bruce H R Wolffenbuttel
No abstract text is available yet for this article.
October 27, 2016: Journal of Diabetes
Kristin H X Tan, Elizabeth L M Barr, Vira Koshkina, Stefan Ma, Sudhir Kowlessur, Dianna J Magliano, Stefan Söderberg, Kee Seng Chia, Paul Zimmet, Wei-Yen Lim
BACKGROUND: Asia is experiencing a type 2 diabetes epidemic, but prevalence differs by ethnicity and level of socioeconomic development. Singapore and Mauritius have implemented comprehensive campaigns to address this public health problem. We compared diabetes and obesity prevalence trends among Chinese and South Asians living in Singapore and Mauritius to determine the contribution of ethnicity and economic development to diabetes. METHODS: Age-specific data from serial national population-based surveys in Singapore and Mauritius between 1987 and 2010 were used to estimate age-standardized diabetes and obesity prevalence...
October 25, 2016: Journal of Diabetes
Salma A Khattab, Dina M Abo-Elmatty, Maivel H Ghattas, Noha M Mesbah, Eman T Mehanna
BACKGROUND: The intestinal fatty acid binding protein (FABP-2) is expressed in enterocytes and binds saturated and unsaturated long-chain fatty acids. FABP-2 Ala54Thr polymorphism was reported to have an influence on lipid metabolism. This study aimed to assess the relation of this polymorphism with peripheral atherosclerosis combined with type 2 diabetes mellitus in an Egyptian population. METHODS: The study included 100 diabetic patients with peripheral atherosclerosis and 100 control subjects...
October 25, 2016: Journal of Diabetes
Abigail E Dove, Payal H Marathe, Helen X Gao, Sarah A Odeh, Kelly L Close
No abstract text is available yet for this article.
October 20, 2016: Journal of Diabetes
Hideaki Kaneto, Atsushi Obata, Tomohiko Kimura, Masashi Shimoda, Seizo Okauchi, Naoki Shimo, Taka-Aki Matsuoka, Kohei Kaku
Type 2 diabetes mellitus is characterized by insulin resistance in various insulin target tissues, such as the liver, adipose tissue, and skeletal muscle, and insufficient insulin secretion from pancreatic β-cells. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, which are newly developed antidiabetic agents, decrease blood glucose levels by enhancing urinary glucose excretion and thereby function in an insulin-independent manner. Sodium-glucose cotransporter 2 inhibitors exert beneficial effects to reduce insulin resistance and preserve pancreatic β-cell function...
October 18, 2016: Journal of Diabetes
Yoshihiro Ikura, Dina G Tiniakos, Takeshi Tanaka, Kenichi Harada
No abstract text is available yet for this article.
October 18, 2016: Journal of Diabetes
Ying Liu, Kesheng Wang, Mildred Maisonet, Liang Wang, Shimin Zheng
BACKGROUND: Over the long term, unhealthy lifestyles can lead to many health problems, especially type 2 diabetes (T2D). The aim of the present study was to determine associations between lifestyle factors (smoking, alcohol consumption, physical activity, and diet) and T2D in American adults (aged ≥20 years) in a nationally representative sample. METHODS: Data for 12 987 American adults participating in the National Health and Nutrition Examination Survey 2005-2014 were evaluated...
October 17, 2016: Journal of Diabetes
Zachary Bloomgarden
No abstract text is available yet for this article.
October 13, 2016: Journal of Diabetes
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