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Advances in Hematology

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https://www.readbyqxmd.com/read/29692812/association-of-peripheral-monocyte-count-with-soluble-p-selectin-and-advanced-stages-in-nasopharyngeal-carcinoma
#1
Adi Surya Komala, Andhika Rachman
Introduction: Inflammation is widely recognized to play an important role in cancer progression and is related to thrombosis. Soluble P-selectin (sP-selectin) is one of several biomarkers that may be predictive of thrombosis in cancer. This study aimed to investigate the correlation between monocyte count and sP-selectin in various stages of nasopharyngeal carcinoma. Methods: Fifty-five patients with nasopharyngeal carcinoma were divided into three groups according to nodal and distant metastasis (group of stages I-IVA, IVB, and IVC)...
2018: Advances in Hematology
https://www.readbyqxmd.com/read/29610574/impact-of-age-on-outcomes-in-hospitalized-patients-with-hereditary-hemorrhagic-telangiectasia
#2
Vivek N Iyer, Waleed Brinjikji, Dinesh Apala, Bibek S Pannu, Aditya Kotecha, Michael D Leise, Patrick S Kamath, Sanjay Misra, Giuseppe Lanzino, Michael J Krowka, Christopher P Wood, Karen L Swanson
Background: There is little published literature regarding the impact of age on outcomes amongst hospitalized HHT (hereditary hemorrhagic telangiectasia) patients. Methods: The Nationwide Inpatient Sample (NIS) was used to obtain data on all hospital discharges occurring in HHT patients from 2000 to 2012. The association between admission age and HHT-related complications and outcomes were studied. Results: 10293 hospitalizations in HHT patients from 2000 to 2012 were included...
2018: Advances in Hematology
https://www.readbyqxmd.com/read/29362564/prognostic-factors-for-immune-thrombocytopenia-outcome-in-greek-children-a-retrospective-single-centered-analysis
#3
Alexandros Makis, Athanasios Gkoutsias, Theodoros Palianopoulos, Eleni Pappa, Evangelia Papapetrou, Christina Tsaousi, Eleftheria Hatzimichael, Nikolaos Chaliasos
Immune thrombocytopenia (ITP) in children has a varied course and according to duration is distinguished as newly diagnosed (<3 months), persistent (3-12), and chronic (>12) types. Several studies have evaluated the prognostic factors for the progression of the disease, but similar works have yet to be performed in Greece. We aimed to identify prognostic markers for the three forms of the disease in 57 Greek children during a 13-year period. Information regarding age, gender, preceding infection, bleeding type, duration of symptoms and platelets at diagnosis, treatment, disease course, and immunological markers was recorded...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/29250116/chimerism-in-myeloid-malignancies-following-stem-cell-transplantation-using-flubu4-with-and-without-busulfan-pharmacokinetics-versus-bucy
#4
Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman
In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu pharmacokinetics (Bu PK) and those who received busulfan with cyclophosphamide (BuCy). Fifty-five patients received FluBu4, of whom 21 had Bu PK measured, and 23 patients received BuCy. Total donor cell chimerism showed that the percentage of patients maintaining 100% donor chimerism on day 100 was 66...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/29204156/sp17-protein-expression-and-major-histocompatibility-class-i-and-ii-epitope-presentation-in-diffuse-large-b-cell-lymphoma-patients
#5
Kamel Ait-Tahar, Amanda P Anderson, Martin Barnardo, Graham P Collins, Chris S R Hatton, Alison H Banham, Karen Pulford
Improved therapies are urgently needed for patients with diffuse large B cell lymphoma (DLBCL). Success using immune checkpoint inhibitors and chimeric antigen receptor T cell technology has fuelled demand for validated cancer epitopes. Immunogenic cancer testis antigens (CTAs), with their widespread expression in many tumours but highly restricted normal tissue distribution, represent attractive immunotherapeutic targets that may improve treatment options for DLBCL and other malignancies. Sperm protein 17 (Sp17), a CTA reported to be immunogenic in ovarian cancer and myeloma patients, is expressed in DLBCL...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/28798772/study-of-erythrocyte-indices-erythrocyte-morphometric-indicators-and-oxygen-binding-properties-of-hemoglobin-hematoporphyrin-patients-with-cardiovascular-diseases
#6
Victor V Revin, Antonina A Ushakova, Natalia V Gromova, Larisa A Balykova, Elvira S Revina, Vera V Stolyarova, Tatiana A Stolbova, Ilya N Solomadin, Alexander Yu Tychkov, Nadezhda V Revina, Oksana G Imarova
The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. The authors believe that it is necessary for future therapeutic treatment to include preparations other than cardiovascular agents to enhance the capacity of hemoglobin to transport oxygen to the tissues...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/28588617/outcomes-of-six-dose-high-dose-cytarabine-as-a-salvage-regimen-for-patients-with-relapsed-refractory-acute-myeloid-leukemia
#7
Brandi Anders, Lauren Veltri, Abraham S Kanate, Alexandra Shillingburg, Nilay Shah, Michael Craig, Aaron Cumpston
Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). Limited data exists, regarding the optimal regimen to obtain remission prior to allo-HCT. Single agent high-dose cytarabine (10-12 doses administered every 12 hours) has been previously used as induction therapy. Six-dose high-dose cytarabine (HiDAC-6), commonly used as a consolidation regimen, has never been evaluated as induction therapy...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/28584527/efficacy-and-safety-of-manual-partial-red-cell-exchange-in-the-management-of-severe-complications-of-sickle-cell-disease-in-a-developing-country
#8
B F Faye, D Sow, M Seck, N Dieng, S A Toure, M Gadji, A B Senghor, Y B Gueye, D Sy, A Sall, T N Dieye, A O Toure, S Diop
INTRODUCTION: The realization of red cell exchange (RCE) in Africa faces the lack of blood, transfusion safety, and equipment. We evaluated its efficacy and safety in severe complications of sickle cell disease. PATIENTS AND METHOD: Manual partial RCE was performed among sickle cell patients who had severe complications. Efficacy was evaluated by clinical evolution, blood count, and electrophoresis of hemoglobin. Safety was evaluated on adverse effects, infections, and alloimmunization...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/28321258/the-evolution-of-prognostic-factors-in-multiple-myeloma
#9
REVIEW
Amr Hanbali, Mona Hassanein, Walid Rasheed, Mahmoud Aljurf, Fahad Alsharif
Multiple myeloma (MM) is a heterogeneous hematologic malignancy involving the proliferation of plasma cells derived by different genetic events contributing to the development, progression, and prognosis of this disease. Despite improvement in treatment strategies of MM over the last decade, the disease remains incurable. All efforts are currently focused on understanding the prognostic markers of the disease hoping to incorporate the new therapeutic modalities to convert the disease into curable one. We present this comprehensive review to summarize the current standard prognostic markers used in MM along with novel techniques that are still in development and highlight their implications in current clinical practice...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/27703480/glucose-6-phosphate-dehydrogenase-deficiency-and-sickle-cell-trait-among-prospective-blood-donors-a-cross-sectional-study-in-berekum-ghana
#10
Patrick Adu, David Larbi Simpong, Godfred Takyi, Richard K D Ephraim
Background. Blood transfusion is a therapeutic procedure usually undertaken in patients with severe anaemia. In Ghana, severe anaemia is mostly due to malaria caused by severe Plasmodium falciparum infection, road traffic accidents, and haemoglobinopathy-induced acute haemolysis. Method. This cross-sectional study evaluated coinheritance of sickle cell haemoglobin variant and G6PD enzymopathy among individuals that donated blood at the Holy Trinity Hospital, Berekum, in the Brong-Ahafo Region, Ghana. Demographic data and other pertinent information were captured using questionnaire...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27635143/autologous-graft-versus-tumor-effect-reality-or-fiction
#11
REVIEW
Luis F Porrata
In contrast to allogeneic hematopoietic stem cell transplantation, the current dogma is not an evidence of graft-versus-tumor effect in autologous hematopoietic stem cell transplantation; thus, it is assumed that autologous hematopoietic stem cell transplantation only relies on the high-dose chemotherapy to improve clinical outcomes. However, recent studies argue in favor of the existence of an autologous graft-versus-tumor without the detrimental complications of graft-versus-host disease due to the nonspecific immune response from the infused donor alloreactive immune effector cells in allogeneic hematopoietic stem cell transplantation...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27340406/haploidentical-family-donor-transplantation-at-the-crossroads-of-a-changing-paradigm
#12
Suparno Chakrabarti, Franco Aversa, Yair Reisner, Paul O'Donnell
No abstract text is available yet for this article.
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27313619/haploidentical-stem-cell-transplantation-in-adult-haematological-malignancies
#13
REVIEW
Kevon Parmesar, Kavita Raj
Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27293440/clinical-scenarios-for-discordant-anti-xa
#14
REVIEW
Jesus Vera-Aguilera, Hindi Yousef, Diego Beltran-Melgarejo, Teng Hugh Teng, Ramos Jan, Mary Mok, Carlos Vera-Aguilera, Eduardo Moreno-Aguilera
Anti-Xa test measures the activity of heparin against the activity of activated coagulation factor X; significant variability of anti-Xa levels in common clinical scenarios has been observed. Objective. To review the most common clinical settings in which anti-Xa results can be bias. Evidence Review. Guidelines and current literature search: we used PubMed, Medline, Embase, and MEDION, from 2000 to October 2013. Results. Anti-Xa test is widely used; however the assay underestimates heparin concentration in the presence of significant AT deficiency, pregnancy, end stage renal disease, and postthrombolysis and in patients with hyperbilirubinemia; limited published data evaluating the safety and effectiveness of anti-Xa assays for managing UH therapy is available...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27239198/combined-bone-marrow-and-kidney-transplantation-for-the-induction-of-specific-tolerance
#15
REVIEW
Yi-Bin Chen, Tatsuo Kawai, Thomas R Spitzer
The induction of specific tolerance, in order to avoid the detrimental effects of lifelong systemic immunosuppressive therapy after organ transplantation, has been considered the "Holy Grail" of transplantation. Experimentally, tolerance has been achieved through clonal deletion, through costimulatory blockade, through the induction or infusion of regulatory T-cells, and through the establishment of hematopoietic chimerism following donor bone marrow transplantation. The focus of this review is how tolerance has been achieved following combined bone marrow and kidney transplantation...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27143973/hla-haplotype-mismatch-transplants-and-posttransplant-cyclophosphamide
#16
REVIEW
Andrea Bacigalupo, Simona Sica
The use of high dose posttransplant cyclophosphamide (PT-CY) introduced by the Baltimore group approximately 10 years ago has been rapidly adopted worldwide and is becoming a standard for patients undergoing unmanipulated haploidentical (HAPLO) transplants. PT-CY has been used following nonmyeloablative as well as myeloablative conditioning regimens, for bone marrow or peripheral blood grafts, for patients with malignant and nonmalignant disorders. Retrospective comparisons of HAPLO grafts with conventional sibling and unrelated donor grafts have been published and suggest comparable outcome...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27118973/choice-of-unmanipulated-t-cell-replete-graft-for-haploidentical-stem-cell-transplant-and-posttransplant-cyclophosphamide-in-hematologic-malignancies-in-adults-peripheral-blood-or-bone-marrow-review-of-published-literature
#17
REVIEW
Shatha Farhan, Edward Peres, Nalini Janakiraman
Allogeneic hematopoietic stem cell transplantation (SCT) is often the only curative option for many patients with malignant and benign hematological stem cell disorders. However, some issues are still of concern regarding finding a donor like shrinking family sizes in many societies, underrepresentation of the ethnic minorities in the registries, genetic variability for some races, and significant delays in obtaining stem cells after starting the search. So there is a considerable need to develop alternate donor stem cell sources...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27110244/retracted-plasmablastic-lymphoma-a-review-of-current-knowledge-and-future-directions
#18
Advances In Hematology
[This retracts the article DOI: 10.1155/2015/315289.].
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27110243/haploidentical-transplantation-in-children-with-acute-leukemia-the-unresolved-issues
#19
REVIEW
Sarita Rani Jaiswal, Suparno Chakrabarti
Allogeneic hematopoietic stem cell transplantation (HSCT) remains a curative option for children with high risk and advanced acute leukemia. Yet availability of matched family donor limits its use and although matched unrelated donor or mismatched umbilical cord blood (UCB) are viable options, they fail to meet the global need. Haploidentical family donor is almost universally available and is emerging as the alternate donor of choice in adult patients. However, the same is not true in the case of children...
2016: Advances in Hematology
https://www.readbyqxmd.com/read/27034676/review-on-haploidentical-hematopoietic-cell-transplantation-in-patients-with-hematologic-malignancies
#20
REVIEW
William A Fabricius, Muthalagu Ramanathan
Allogenic hematopoietic cell transplantation (HSCT) is typically the preferred curative therapy for adult patients with acute myeloid leukemia, but its use has been reduced as a consequence of limited donor availability in the form of either matched-related donors (MRD) or matched-unrelated donors (MUD). Alternative options such as unrelated umbilical cord blood (UCB) transplantation and haploidentical HSCT have been increasingly studied in the past few decades to overcome these obstacles. A human leukocyte antigen- (HLA-) haploidentical donor is a recipient's relative who shares an exact haplotype with the recipient but is mismatched for HLA genes on the unshared haplotype...
2016: Advances in Hematology
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