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https://www.readbyqxmd.com/read/29669962/renal-protective-effect-of-paeoniflorin-by-inhibition-of-jak2-stat3-signaling-pathway-in-diabetic-mice
#1
Xinyu Li, Yan Wang, Kun Wang, Yonggui Wu
Paeoniflorin is the main bioactive components of the root of P.lactiflora Pall., and has been widely used as an anti-inflammation and immunomodulatory agent. However, the effect and mechanisms of Paeoniflorin in diabetic nephropathy (DN) remains to be elucidated. In the present study, streptozotocin (STZ)-induced type 1 diabetic mice model was used to investigate the protective effect of Paeoniflorin and the role of the Janus kinase (JAK) 2/signal transducer (STAT) 3 signaling pathway on DN. After treatment with Paeoniflorin at a dose of 25, 50 and 100 mg/kg once a day for 12 weeks, both the functional and histological damage to diabetic mice kidney had been attenuated significantly...
April 19, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657246/effects-of-three-forms-of-local-anesthesia-on-perioperative-fentanyl-induced-hyperalgesia
#2
Lu Chang, Fang Ye, Quehua Luo, Zewen Wang, Yimin Wang, Zhengyuan Xia, Haihua Shu
Both local infiltration analgesia (LIA) and nerve block are common analgesic modalities for pain relief after surgery. The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia. Rats were injected with fentanyl (60 μg/kg) 4 times and received a plantar incision after the second injection or they received pre-incision LIA and sciatic nerve block (SNB) or post-incision LIA with levobupivacaine (0...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657245/strengthening-maternal-and-child-health-in-china-lessons-from-transforming-policy-proposals-into-action
#3
Xiaoguang Yang, Shenglan Tang, Gavin Yamey, Xu Qian
China has made impressive achievements in improving maternal and child health (MCH) over the past few decades. This paper uses a policy lens to examine reasons for these achievements as well as barriers to further success. We found that strong governmental commitment and leadership, effective coordination, proactive participation of different stakeholders, and the provision of adequate resources were associated with China's success in improving MCH outcomes. Other low- and middle-income countries can learn valuable lessons from China's experience...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657244/infiltration-characteristics-and-influencing-factors-of-retroperitoneal-liposarcoma-novel-evidence-for-extended-surgery-and-a-tumor-grading-system
#4
Zhen Wang, Jianhui Wu, Ang Lv, Chengpeng Li, Zhongwu Li, Min Zhao, Chunyi Hao
This study sought to evaluate the infiltration tendency of retroperitoneal liposarcoma (RPLS) from a new pathological angle by exploring the infiltration characteristics, which could provide helpful information to facilitate surgical decision-making and prognosis prediction. Concurrently, we aim to identify significant indicators of infiltration. A total of 61 consecutive patients with RPLS at our institution were retrospectively analyzed. All patients received extended surgery. The tumor infiltration characteristics and influencing factors were studied based on the pathological diagnosis...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657243/distinct-pattern-of-th17-treg-cells-in-pregnant-women-with-a-history-of-unexplained-recurrent-spontaneous-abortion
#5
Jinfeng Qian, Na Zhang, Jing Lin, Caiyan Wang, Xinyao Pan, Lanting Chen, Dajin Li, Ling Wang
The aim of the current study was to determine the pattern of immune cells and related functional molecules in peripheral blood and at the maternal-fetal interface in women with unexplained recurrent spontaneous abortion (URSA). In part I, 155 women were included and divided into four groups: non-pregnant controls with no history of URSA (NPCs), pregnant controls with no history of URSA (PCs), non-pregnant women with a history of URSA (NPUs), and pregnant women with a history of URSA (PUs). Venous blood samples were collected and analyzed...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29657242/diagnosis-related-group-drg-based-case-mix-funding-system-a-promising-alternative-for-fee-for-service-payment-in-china
#6
Cuirong Zhao, Chao Wang, Chengwu Shen, Qian Wang
Fee for services (FFS) is the prevailing method of payment in most Chinese public hospitals. Under this retrospective payment system, medical care providers are paid based on medical services and tend to over-treat to maximize their income, thereby contributing to rising medical costs and uncontrollable health expenditures to a large extent. Payment reform needs to be promptly implemented to move to a prospective payment plan. The diagnosis-related group (DRG)-based case-mix payment system, with its superior efficiency and containment of costs, has garnered increased attention and it represents a promising alternative...
April 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29607874/astraglaus-polysaccharide-protects-diabetic-cardiomyopathy-by-activating-nrg1-erbb-pathway
#7
Xiao Chang, Kang Lu, Ling Wang, Min Lv, Wenjun Fu
Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic patients. According to previous studies, the pathogenesis of DCM is associated with oxidative stress, apoptosis and proliferation of local cardiac cells. It showed, NRG1 can improve the function of mitochondria, and thereby, increasing proliferation and decreasing apoptosis of cardiac muscle cell via ErbB/AKT signaling, also, exert antioxidative function. Besides, NRG1/ErbB pathway was impaired in the DCM model which suggested this signaling played key role in DCM...
April 2, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29607873/internal-migration-and-regional-differences-of-population-aging-an-empirical-study-of-287-cities-in-china
#8
Rong Chen, Ping Xu, Fen Li, Peipei Song
In addition to birth and death, migration is also an important factor that determines the level of population aging in different regions, especially under the current context of low fertility and low mortality in China. Drawing upon data from the fifth and sixth national population census of 287 prefecture-level cities in China, this study explored the spatial patterns of population aging and its trends from 2000 to 2010 in China. We further examined how the large-scale internal migration was related to the spatial differences and the changes of aging by using multivariate quantitative models...
April 2, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29479018/core-factors-promoting-a-continuum-of-care-for-maternal-newborn-and-child-health-in-japan
#9
Hidechika Akashi, Miwa Ishioka, Akiko Hagiwara, Rumiko Akashi, Yasuyo Osanai
Providing a continuum of care (CoC) is important strategy for improving maternal, newborn, and child health (MNCH). Japan's current very low maternal and infant mortality rates suggest that its CoC for MNCH is good. In this paper, we attempt to clarify how CoC and low mortality rates are being maintained in Japan, by examining the entire MNCH service provision system. First, we examine two important tools for integrated service provision, the Maternal and Child Health (MCH) Handbook and registration of pregnant women with local governments, both introduced in 1942...
February 26, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29479017/japan-s-healthcare-policy-for-the-elderly-through-the-concepts-of-self-help-ji-jo-mutual-aid-go-jo-social-solidarity-care-kyo-jo-and-governmental-care-ko-jo
#10
Kyoko Sudo, Jun Kobayashi, Shinichiro Noda, Yoshiharu Fukuda, Kenzo Takahashi
Elderly care is an emerging global issue threatening both developed and developing countries. The elderly in Japan increased to 26.7% of the population in 2015, and Japan is classified as a super-aged society. In this article, we introduce the financial aspects of the medical care and welfare services policy for the elderly in Japan. Japan's universal health insurance coverage system has been in place since 1961. Long-term care includes welfare services, which were separated from the medical care insurance scheme in 2000 when Japan was already recognized as an aging society...
February 26, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29332928/optical-coherence-tomography-for-precision-brain-imaging-neurosurgical-guidance-and-minimally-invasive-theranostics
#11
Yingwei Fan, Yan Xia, Xinran Zhang, Yu Sun, Jie Tang, Liwei Zhang, Hongen Liao
This review focuses on optical coherence tomography (OCT)-based neurosurgical application for imaging and treatment of brain tumors. OCT has emerged as one of the most innovative and successful translational biomedical-diagnostic techniques. It is a useful imaging tool for noninvasive, in vivo, in situ and real-time imaging in soft biological tissues, such as brain tumor imaging. OCT can detect the structure of biological tissue in a micrometer scale, and functional OCT has some clinical researches and applications, such as nerve fiber tracts and neurovascular imaging...
March 18, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29332927/the-response-of-common-marmoset-immunity-against-cedar-pollen-extract
#12
Yoshie Kametani, Yuko Yamada, Shuji Takabayashi, Hideki Kato, Kenji Ishiwata, Naohiro Watanabe, Erika Sasaki, Sonoko Habu
The in vivo model of pollinosis has been established using rodents, but the model cannot completely mimic human pollinosis. We used Callithrix jacchus, the common marmoset (CM), to establish a pollinosis animal model using intranasal weekly administration of cedar pollen extract with cholera toxin adjuvant. Some of the treated CMs exhibited the symptoms of snitching, excess nasal mucus and/or sneezing, but the period was very short, and the symptoms disappeared after several weeks. The CD4+CD25+ cell ratio in the peripheral blood increased in CMs quickly after the nasal administration of cedar pollen extract, but the timing was not parallel with the symptoms...
March 18, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29269714/low-density-lipoprotein-receptor-deficiency-impaired-mice-osteoblastogenesis-in-vitro
#13
Na Zhang, Yang Zhang, Jing Lin, Xuemin Qiu, Lanting Chen, Xinyao Pan, Youhui Lu, Jiali Zhang, Yan Wang, Dajin Li, Ling Wang
Postmenopausal osteoporosis affected most elderly women with co-existence of lipid and bone metabolism disorders. However, the cellular and molecular mechanisms underlying the parallel progression and cross-talk of these systems remained unclear. In the present study, low-density lipoprotein receptor knockout (LDLR-/- ) mice were chosen to elucidate the effect of LDLR in regulating the differentiation of osteoblasts, which were responsible for bone formation and modulation of osteoclastogenesis. Primary osteoblasts were isolated from the calvarium of newborn LDLR-/- or wild-type mice followed by osteoblastic differentiation culture in vitro...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29269713/the-effects-of-health-education-and-promotion-with-regard-to-severe-fever-with-thrombocytopenia-syndrome-sfts-in-rural-residents-a-pilot-study-in-china
#14
Yuyan Wu, Guiming Fu, Song Guo, Ling Ye, Juan Hou, Jinna Wang, Zhenyu Gong
Severe fever with thrombocytopenia syndrome (SFTS) has spread throughout Asia, including China, South Korea, and Japan. In China, the main victims of SFTS were farmers. Measures to protect farmers were urgently needed but limited, and health education and promotion was proposed as an option. A pilot community trial was conducted to provide health education about SFTS in 2013 in Daishan County, Zhejiang Province, China, and results indicated that health education had promise. An educational campaign was conducted for three years...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29249774/effects-of-lifestyle-advice-provided-by-pharmacists-on-blood-pressure-the-community-pharmacists-assist-for-blood-pressure-compass-bp-randomized-trial
#15
Hiroshi Okada, Mitsuko Onda, Masaki Shoji, Naoki Sakane, Yasushi Nakagawa, Takashi Sozu, Yui Kitajima, Ross T Tsuyuki, Takeo Nakayama
The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by their pharmacy randomization...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29249773/does-pneumoperitoneum-affect-perfusion-index-and-pleth-variability-index-in-patients-receiving-combined-epidural-and-general-anesthesia
#16
Zen'ichiro Wajima, Toshiya Shiga, Kazuyuki Imanaga
Plethysmographic variability index (PVI) is a dynamic index used for the purpose of fluid responsiveness in patients, and the effect of pneumoperitoneum on PVI is still unclear. We therefore attempted to determine whether PVI and perfusion index (PI) change before/after pneumoperitoneum in patients receiving combined epidural and general anesthesia, which is a common anesthesia method with intravenous remifentanil. Twenty patients underwent laparoscopic cholecystectomy or colectomy. Immediately before pneumoperitoneum, variables were measured at baseline I and were then measured every min for 5 min after pneumoperitoneum start...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29249727/expression-purification-and-biological-characterization-of-anaplasma-phagocytophilum-enolase
#17
Xiaoge Gao, Chen Zheng, Xiangye Liu
The obligate intracellular bacteria Anaplasma phagocytophilum is the etiological agent of human granulocytic anaplasmosis (HGA), an acute febrile tick-borne disease. A. phagocytophilum has a complex lifecycle within both vertebrate reservoirs and tick vectors, and employs a range of different molecules to infect and multiply within the host cells. Enolase is an essential glycolytic enzyme in intracellular glucose metabolism, but is also a multifunctional protein expressed on the pathogen surface, that binds to and promotes plasminogen conversion to plasmin...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29238003/direct-acting-agents-for-hepatitis-c-virus-before-and-after-liver-transplantation
#18
Yasuhiko Sugawara, Taizo Hibi
Chronic hepatitis C virus (HCV) infection remains a widespread public health concern and many people are infected with HCV. HCV is one of the leading indications for liver transplantation. Direct-acting antiviral agents (DAAs) against HCV have changed the course of chronic HCV infection, however, making it a curable disease. DAA treatment may be initiated before or after liver transplantation. In the present review, we present the available data on DAA treatment of HCV in liver transplant recipients.
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29238002/yin-yang-regulating-effects-of-cancer-associated-genes-proteins-and-cells-an-ancient-chinese-concept-in-vogue-in-modern-cancer-research
#19
Shuyong Wei
Great achievements have been made in human cancer research, but most of this research is focused on conditions at the microscopic rather than the systemic level. Recent studies have increasingly cited the ancient Chinese theory of yin-yang in an effort to expand beyond the microscopic level. Various cancer-associated genes and proteins such as mitogen-activated protein kinase (MAPK), p38, p53, c-Myc, tumor necrosis factor (TNF)-α, NF-κB, Cyclin D1, and cyclin-dependent kinase (CDK) and cells such as T cells, B cells, macrophages, neutrophils, and fibroblasts have been reported to regulate various types of cancers in a yin-yang manner...
January 9, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29225282/the-impact-of-population-aging-on-medical-expenses-a-big-data-study-based-on-the-life-table
#20
Changying Wang, Fen Li, Linan Wang, Wentao Zhou, Bifan Zhu, Xiaoxi Zhang, Lingling Ding, Zhimin He, Peipei Song, Chunlin Jin
This study shed light on the amount and structure of utilization and medical expenses on Shanghai permanent residents based on big data, simulated lifetime medical expenses through combining of expenses data and life table model, and explored the dynamic pattern of aging on medical expenditures. 5 years were taken as the class interval, the study collected and did the descriptive analysis on the medical services utilization and medical expenses information for all ages of Shanghai permanent residents in 2015, simulated lifetime medical expenses by using current life table and cross-section expenditure data...
January 9, 2018: Bioscience Trends
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