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Bioscience Trends

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https://www.readbyqxmd.com/read/28626211/once-malaria-is-eliminated-more-attention-should-be-paid-to-imported-malaria-data-from-five-years-of-surveillance-in-the-city-of-yiwu-in-eastern-china
#1
Xuanjun Dong, Jie Yang, Lianqin Lou, Liebo Zhu, Xiayan Feng, Linong Yao
This study reviewed and analyzed data on malaria cases in Yiwu from 2012 to 2016 via a webbased system for managing and reporting information on infectious diseases. A total of 161 cases were diagnosed (77.02% due to Plasmodium falciparum, 18.01% due to P. vivax, 4.35% due to P. ovale, and 0.62% due to P. malariae). One case was imported from Yunnan Province in China and the others were imported from overseas. The ratio of male to female patients was 7.47:1. The average age was 36.34 years (SD: 9.63). Most cases (87...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28626210/clinical-correspondence-to-hepatocellular-carcinoma-related-lesions-with-atypical-radiological-pattern
#2
Tokio Higaki, Yutaka Midorikawa, Yosuke Nakashima, Hisashi Nakayama, Shunichi Matsuoka, Mitsuhiko Moriyama, Masahiko Sugitani, Tadatoshi Takayama
In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patients with non-enhanced tumors or enhanced tumors without washout were divided into two groups: those with tumors that should be treated containing well, moderately, and poorly differentiated HCC (Group 1), and those that can be observed containing early HCC, hepatocellular adenoma, focal nodular hyperplasia, dysplastic nodules, and regenerative nodules (Group 2), and we elucidated the clinical correspondence to these tumors...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28626209/paeoniflorin-prevents-tlr2-4-mediated-inflammation-in-type-2-diabetic-nephropathy
#3
Tingmin Zhang, Qijin Zhu, Yunxia Shao, Kun Wang, Yonggui Wu
Paeoniflorin is an effective Chinese traditional medicine with anti-inflammatory and immune-regulatory effects. The aim of this study was to investigate the underlying renoprotective mechanism of Paeoniflorin. In vivo, db/db mice were intraperitoneally injected with Paeoniflorin at a dose of 15, 30, or 60 mg/kg respectively. The immunostaining of TLR2, TLR4, CD68, NF-kB p65 and the mRNA level of inflammatory factors, together with the protein expression of TLR2/4 signaling were evaluated. Our data demonstrated that Paeoniflorin could decrease the urinary albumin excretion rate and inhibit macrophage infiltration and activation through blockage of the TLR2/4 signaling pathway compared with the db/db group in vivo...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28626208/posttraumatic-stress-disorder-eliminates-association-of-trkb-rs1187327-with-hdl-c-in-chinese-han-adolescents
#4
Ting Cao, Qiwei Guo, Mi Su, Yue Feng, Mei Fan, Yanjun Si, Nazakat H Memon, Jia Lin, Dingzhi Fang
Tropomyosin-related kinase receptor B (TrkB) has been observed to be a common player in posttraumatic stress disorder (PTSD) and the regulation of serum lipids levels. However, interplays of PTSD with TrkB on serum lipids levels have not been explored yet. This study was to investigate the interplays of PTSD and TrkB rs1187327 on serum lipid profiles. Variants of TrkB rs1187327 of 709 high school students were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28579578/the-t-box-transcription-factor-3-in-development-and-cancer
#5
Tarryn Willmer, Aretha Cooper, Jade Peres, Rehana Omar, Sharon Prince
T-box factors comprise an archaic family of evolutionary conserved transcription factors that regulate patterns of gene expression essential for embryonic development. The T-box transcription factor 3 (TBX3), a member of this family, is expressed in several tissues and plays critical roles in, among other structures, the heart, mammary gland and limbs and haploinsufficiency of the human TBX3 gene is the genetic basis for the autosomal dominant disorder, ulnar-mammary syndrome. Overexpression of TBX3 on the other hand has been linked to several cancers including melanoma, breast, pancreatic, liver, lung, head and neck, ovarian, bladder carcinomas and a number of sarcoma subtypes...
June 4, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28552898/sustained-release-vancomycin-coated-titanium-alloy-using-a-novel-electrostatic-dry-powder-coating-technique-may-be-a-potential-strategy-to-reduce-implant-related-infection
#6
Jing Han, Yi Yang, Junren Lu, Chenzhong Wang, Youtao Xie, Xuebin Zheng, Zhenjun Yao, Chi Zhang
In order to tackle the implant-related infection, a novel way was developed in this study to coat vancomycin particles mixed with controlled release coating materials onto the surface of titanium alloy by using an electrostatic dry powder coating technique. To characterize this sustained release antibacterial coating, surface morphology, in vitro and in vivo drug release were sequentially evaluated. In vitro cytotoxicity was tested by Cell Counting Kit-8 (CCK-8) assay and cytological changes were observed by inverted microscope...
May 26, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28529266/preoperative-biliary-drainage-versus-direct-surgery-for-perihilar-cholangiocarcinoma-a-retrospective-study-at-a-single-center
#7
Yulong Cai, Qi Tang, Xianze Xiong, Fuyu Li, Hui Ye, Peipei Song, Nansheng Cheng
Perihilar cholangiocarcinoma (pCC, also known as a Klatskin tumor) is the most common type of cholangiocarcinoma (CC). Preoperative biliary drainage (PBD) is indicated for pCC patients with acute cholangitis or patients who need portal vein embolization (PVE). However, the routine performance of PBD in other patients with pCC is still controversial. The current study retrospectively examined patients with pCC who did not undergo PVE and who did not have cholangitis who were seen at this Hospital to assess the advantages and disadvantages of PBD...
May 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28529265/comparative-transcriptomic-analysis-identifies-reprogramming-and-differentiation-genes-differentially-expressed-in-uipscs-and-escs
#8
Liang Shi, Yazhou Cui, Xiaoyan Zhou, Jing Luan, Linli Wang, Jinxiang Han
Embryonic stem cells (ESCs) technology has garnered worldwide attention for its therapeutic applications in vivo. Researchers have previously shown that non-viral induced pluripotent stem cells (iPSCs) can be generated from urine. As a potential alternative, Urinary iPSCs (UiPSCs) are highly similar to embryonic stem cells (ESCs) in many aspects such as morphology, expression of pluripotency markers and the capacity to develop into three germ layers in vitro and in vivo. However, the degree of gene expression similarity between iPSCs and ESCs has not been completely elucidated...
May 20, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484189/perfusion-and-drainage-difference-in-the-liver-parenchyma-regional-plane-in-segment-6
#9
Hayato Abe, Shintaro Yamazaki, Masamichi Moriguchi, Tokio Higaki, Tadatoshi Takayama
The differences between the perfusion areas of portal vein and the drainage areas of hepatic vein result in the occurrence of either ischemic or congested areas after liver resection. To elucidate which factors are related to the differences between these areas of segment (S) 6 were therefore investigated. The portal-vein-based and hepatic-vein-based regional planes of S6 were defined using the region-growing and Voronoi tessellation methods in 103 consecutive patients who undergo liver resection. Finally, factors related to the difference between the perfusion and drainage areas of S6 were identified...
May 8, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484188/c-to-u-editing-and-site-directed-rna-editing-for-the-correction-of-genetic-mutations
#10
Luyen Thi Vu, Toshifumi Tsukahara
Cytidine to uridine (C-to-U) editing is one type of substitutional RNA editing. It occurs in both mammals and plants. The molecular mechanism of C-to-U editing involves the hydrolytic deamination of a cytosine to a uracil base. C-to-U editing is mediated by RNA-specific cytidine deaminases and several complementation factors, which have not been completely identified. Here, we review recent findings related to the regulation and enzymatic basis of C-to-U RNA editing. More importantly, when C-to-U editing occurs in coding regions, it has the power to reprogram genetic information on the RNA level, therefore it has great potential for applications in transcript repair (diseases related to thymidine to cytidine (T>C) or adenosine to guanosine (A>G) point mutations)...
May 8, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484187/time-series-analysis-of-weekly-influenza-like-illness-rate-using-a-one-year-period-of-factors-in-random-forest-regression
#11
Hongyan Wu, Yunpeng Cai, Yongsheng Wu, Ren Zhong, Qi Li, Jing Zheng, Denan Lin, Ye Li
Influenza, a disease caused by a respiratory virus, sickened over 5,043,127 citizens in Shenzhen, China, from January 2014 to April 2016. An accurate forecasting of outbreaks of influenza-like illness (ILI, here we refer to ILI as the upper respiratory infection) could facilitate public health officials to suggest public health actions earlier. In this study, a random forest regression constructed with a one-year period of factors was adopted to forecast the weekly ILI rate using the clinical data from Shenzhen Health Information Center...
May 8, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484186/index-of-convexity-a-novel-method-for-assessing-liver-functional-reserve-using-technetium-99m-galactosyl-human-serum-albumin-liver-scintigraphy
#12
Takafumi Sato, Junichi Arita, Yosuke Inoue, Rintaro Koga, Yu Takahashi, Akio Saiura
Preoperative evaluation of liver functional reserve is important in hepatobiliary surgery. Although the indocyanine green retention rate at 15 minutes (ICG-R15) is the gold standard for this purpose, a new method without technical complexity would be preferable. We assessed the usefulness of the previously established index of convexity (IOC). In total, 159 consecutive patients who underwent both technetium-99m-galactosyl human serum albumin ((99m)Tc-GSA) scintigraphy and the ICG-R15 were included. Correlation coefficients between indices from (99m)Tc-GSA scintigraphy and blood examinations including ICG-R15 were evaluated, and a conversion formula from the IOC to the ICG-R15 was established...
May 8, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484111/liver-fibrosis-after-antiretroviral-therapy-in-a-longitudinal-cohort-of-sexually-infected-hiv-patients-in-eastern-china
#13
Qian Wei, Haijiang Lin, Yingying Ding, Xing Liu, Qionghai Wu, Weiwei Shen, Meiyang Gao, Na He
We assessed the factors that influenced improvement or progression in human immunodeficiency virus (HIV)-infected patients who were receiving combination antiretroviral therapy (cART). This was a retrospective cohort study of HIV-infected patients receiving cART in Taizhou, Zhejiang, China, 2009-2015. Liver fibrosis was assessed by Fibrosis-4 (FIB-4) score. Improvement of liver fibrosis was defined as having > 30% decrease in FIB-4 from baseline, whereas progression of liver fibrosis was defined as having > 30% increase in FIB-4 score from baseline...
May 6, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28484110/traditional-chinese-medicine-for-human-papillomavirus-hpv-infections-a-systematic-review
#14
Jing Lin, Lanting Chen, Xuemin Qiu, Na Zhang, Qiting Guo, Yan Wang, Mingyan Wang, Hans-J├╝rgen Gober, Dajin Li, Ling Wang
Human papillomavirus (HPV) infections are common and generally harmless, but persistent infections can bring health problems like cancer and genital warts. For the uninfected group, HPV vaccines provide safe and effective protection, but they're type-restricted and expensive. For those infected, so far there have been a handful of treatments for HPV-associated benign or malignant diseases, traditional Chinese medicine being one of them. This systematic review focuses on the application of traditional Chinese medicine in HPV infection and related diseases on the basis of clinical findings...
May 6, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458382/propelling-medical-humanities-in-china
#15
Wei Tang
Advances in the study of the medical humanities and medical humanities education have been made over the past few decades. Many influential journals have published articles examining the role of medical humanities and medical humanities education, the development and evaluation of medical humanities, and the design of a curriculum for medical humanities education in Western countries. However, most articles related to medical humanities in China were published in Chinese, moreover, researchers have worked in relative isolation and published in disparate journals, so their work has not been systematically presented to and evaluated by international readers...
April 30, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458381/using-films-and-television-shows-with-a-medical-theme-as-a-medium-to-accelerate-the-spread-of-medical-humanities
#16
Wenting Chen, Haihong Qian
People have more visual experiences than ever before, and the same is true for situations in medicine. More mature films and television shows with a medical theme have been available over the past 20 years. In mainland China, the TV series "Angel Heart" has generated a wave of universal concern since it truly depicts the work of health care workers and it reflects the sharp distinction between doctors and patients to a certain extent. Riding this wave, many medical documentaries like The Human World have also been launched in China and have garnered sizable audiences...
April 30, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458335/communication-skills-training-adapting-to-the-trends-and-moving-forward
#17
Ye Liu, Yiqin Huang, Hong Gao, Xunjia Cheng
Communication ability is one of the core requirements of doctors' competency. Teaching communication to medical students and junior doctors has attracted much attention. With the challenge of escalating demands, the status of training communication skills has been promoted in the past several decades. The training content was integrated with other courses and various pedagogic approaches have been applied and proved to be effective. Practical strategies and mixed types were highly recommended. However, there are still many problems, including the fragmentation of the training, insufficient practice, inadequate qualified teachers, case adaptation, course localization and impediment from the environment...
April 29, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458334/an-upcoming-program-for-medical-humanities-education-in-fudan-university-s-school-of-basic-medical-sciences
#18
Ye Liu, Xunjia Cheng
No abstract text is available yet for this article.
April 29, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458333/emphasizing-humanities-in-medical-education-promoting-the-integration-of-medical-scientific-spirit-and-medical-humanistic-spirit
#19
Peipei Song, Wei Tang
In the era of the biological-psychological-social medicine model, an ideal of modern medicine is to enhance the humanities in medical education, to foster medical talents with humanistic spirit, and to promote the integration of scientific spirit and humanistic spirit in medicine. Throughout the United States (US), United Kingdom (UK), other Western countries, and some Asian countries like Japan, many medical universities have already integrated the learning of medical humanities in their curricula and recognized their value...
April 29, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28458332/medical-humanities-play-an-important-role-in-improving-the-doctor-patient-relationship
#20
Fan Wang, Zhenzhen Song, Wen Zhang, Yawen Xiao
Doctors in China have been wounded or even killed in frequent violence as conflict between doctors and patients has intensified. China has had a massive dearth of medical students over the past decade and doctors are dissatisfied with conditions in their profession. Conditions in medicine are not conducive to medical reform. This paper notes that the main factors affecting the doctor-patient relationship are a lack of humanity in medicine, the predominance of techniques and technologies, and inappropriate administration of hospitals...
April 29, 2017: Bioscience Trends
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