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Bioscience Trends

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https://www.readbyqxmd.com/read/28420822/re-entry-and-related-predictors-among-hiv-infected-clients-receiving-methadone-maintenance-treatment-in-guangdong-province-china
#1
Xiaofeng Luo, Xiao Gong, Peizhen Zhao, Xia Zou, Wen Chen, Li Ling
This study examined the re-entry characteristics and related predictors among HIV-infected methadone maintenance treatment (MMT) clients in Guangdong, China. Data on HIV-infected MMT clients was obtained from the clinic MMT registration system in Guangdong. Of the 653 participants, only 9.0% remained in the MMT program until the end of the study. For the drop-outs, 70.0% returned to MMT at least once by the end of the study. Re-entry was independently associated with marital status (ORnever married = 2.24, 95% CI: 1...
April 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28420861/potential-proteins-targeted-by-let-7f-5p-in-hela-cells
#2
Yu Wang, Xiujuan Chen, Yi Zhang, Jiandong Song
MicroRNAs are a class of small, endogenous, non-coding RNAs mediating posttranscriptional gene silencing. The current authors hypothesized that let-7f-5p is likely involved in cell invasion and proliferation by regulating the expression of target genes. The current study combined let-7f-5p with iTRAQ to assess its effect on gene expression in HeLa cells. Results indicated that 164 proteins were expressed at different levels in HeLa cells overexpressing let-7f-5p and negative controls and that 172 proteins were expressed at different levels in let-7f-5p-silenced HeLa cells and negative controls...
April 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28420860/comparison-of-the-docetaxel-concentration-in-human-plasma-measured-with-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-and-a-nanoparticle-immunoassay-and-clinical-applications-of-that-assay
#3
Chunmei Geng, Pingli Li, Xuwang Chen, Guiyan Yuan, Nan Guo, Huanjun Liu, Rui Zhang, Ruichen Guo
To determine the feasibility of using a nanoparticle immunoassay for clinical therapeutic drug monitoring (TDM) of docetaxel concentrations, a sensitive and simple method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established to measure the docetaxel concentration in human plasma and the results of LC-MS/MS and the immunoassay were compared. Docetaxel and paclitaxel (the internal standard, or IS) in human plasma were extracted through protein precipitation, separated on a Diamonsil C18 column (150 mm × 4...
April 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28381702/livebearing-or-egg-laying-mammals-27-decisive-nucleotides-of-fam168
#4
Subrata Pramanik, Arne Kutzner, Klaus Heese
In the present study, we determine comprehensive molecular phylogenetic relationships of the novel myelin-associated neurite-outgrowth inhibitor (MANI) gene across the entire eukaryotic lineage. Combined computational genomic and proteomic sequence analyses revealed MANI as one of the two members of the novel family with sequence similarity 168 member (FAM168) genes, consisting of FAM168A and FAM168B, having distinct genetic differences that illustrate diversification in its biological function and genetic taxonomy across the phylogenetic tree...
April 3, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28320981/relationship-between-thromboelastography-and-long-term-ischemic-events-as-gauged-by-the-response-to-clopidogrel-in-patients-undergoing-elective-percutaneous-coronary-intervention
#5
Xumin Hou, Wenzheng Han, Qian Gan, Yuan Liu, Weiyi Fang
Ischemic events after percutaneous coronary intervention (PCI) remain a major concern for patients with coronary heart disease (CHD). The aim of the current study was to investigate whether thromboelastography (TEG) was a satisfactory technique to measure platelet function in vitro in order to improve risk stratification and the individual response to antiplatelet therapy. The diagnostic and prognostic utility of the maximum amplitude of adenosine diphosphate induced platelet-fibrin clots (MAADP) was measured with TEG in 759 patients undergoing elective PCI...
March 19, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28260718/loss-of-setd2-but-not-h3k36me3-correlates-with-aggressive-clinicopathological-features-of-clear-cell-renal-cell-carcinoma-patients
#6
Lei Liu, Renbo Guo, Xiang Zhang, Yiran Liang, Feng Kong, Jue Wang, Zhonghua Xu
Recent studies facilitated by DNA sequencing identified the histone modifying gene SETD2 as the second most frequent mutant gene in sporadic clear cell renal cell carcinoma (ccRCC) patients. SETD2 functions as a tumor suppressor in ccRCC. However, its clinical association and biological functions are not fully delineated. The aim of this study is to evaluate the clinical significance of SETD2 in ccRCC patients. SETD2 and its canonical histone modification product H3K36me3 were analyzed by immunohistochemistry (IHC) in 155 ccRCC patients from two independent cohorts retrospectively...
March 6, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250339/the-evolutionary-appearance-of-signaling-motifs-in-pgrmc1
#7
Michael A Cahill
A complex PGRMC1-centred regulatory system controls multiple cell functions. Although PGRMC1 is phosphorylated at several positions, we do not understand the mechanisms regulating its function. PGRMC1 is the archetypal member of the membrane associated progesterone receptor (MAPR) family. Phylogentic comparison of MAPR proteins suggests that the ancestral metazoan "PGRMC-like" MAPR gene resembled PGRMC1/PGRMC2, containing the equivalents of PGRMC1 Y139 and Y180 SH2 target motifs. It later acquired a CK2 site with phosphoacceptor at S181...
February 28, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250338/key-role-of-liver-sinusoidal-endothelial-cells-in-liver-fibrosis
#8
Mingxing Xu, Xuehua Wang, Yong Zou, Yuesi Zhong
Because of the prevalence of viral hepatitis and nonalcoholic fatty liver disease (NAFLD), liver fibrosis has become a very common disease in Asia and elsewhere in the world, constantly increasing the burden of care borne by society. Hepatic sinusoidal capillarization, characterized by gradually shrinking fenestrae on the surface of liver sinusoidal endothelial cells (LSECs) and the formation of an organized basement membrane, is an initial pathologic change associated with liver fibrosis. Basic and clinical studies have indicated that LSECs play a key role in hepatic sinusoidal capillarization by affecting various aspects of the development and progression of liver fibrosis...
February 28, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250337/androgen-receptor-gene-cag-repeat-polymorphism-and-ovarian-cancer-risk-a-meta-analysis
#9
Yang Deng, Jue Wang, Ling Wang, Yan Du
Ovarian cancer is one of the common gynecological malignancies worldwide. It is usually diagnosed at a later stage, thus missing the best opportunity for treatment. Despite the advancement of ovarian cancer treatment, the prognosis is still poor. Androgen receptor (AR) may play a role in ovarian carcinogenesis. Previous studies regarding the association between AR CAG repeat length and ovarian cancer risk reported inconsistent results. Therefore, we conducted a meta-analysis to evaluate the association between AR CAG repeat length and ovarian cancer risk following the MOOSE guidelines...
February 28, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250336/the-periplasmic-sensing-domain-of-pseudomonas-fluorescens-chemotactic-transducer-of-amino-acids-type-b-ctab-cloning-refolding-purification-crystallization-and-x-ray-crystallographic-analysis
#10
Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova
Pseudomonas fluorescens is a plant growth promoting rhizobacterium that provides nutrients for growth and induces systemic resistance against plant diseases. It has been linked with a number of human diseases including nosocomial infections and bacterial cystitis. Chemotactic motility of P. fluorescens towards root exudates plays a crucial role in establishing a symbiotic relationship with host plants. The P. fluorescens chemotactic transducer of amino acids type B (CtaB) mediates chemotaxis towards amino acids...
February 28, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250335/role-of-the-pretreatment-18-f-fluorodeoxyglucose-positron-emission-tomography-maximal-standardized-uptake-value-in-predicting-outcomes-of-colon-liver-metastases-and-that-value-s-association-with-beclin-1-expression
#11
Eleonora G Dimitrova, Borislav G Chaushev, Nikolay V Conev, Javor K Kashlov, Aleksandar K Zlatarov, Dilyan P Petrov, Hristo B Popov, Nadezhda T Stefanova, Anelia D Klisarova, Kameliya Z Bratoeva, Ivan S Donev
The current study sought to evaluate the predictive and prognostic performance of the maximum standardized uptake value (SUVmax) prior to treatment in 43 patients with colon cancer and unresectable liver metastases. Patients with colon cancer who underwent (18)F-FDG-PET/computed tomography (CT) scans for staging before the start of first-line 5-fluorouracil-based chemotherapy were retrospectively analyzed. Expression of Beclin-1 in cancer cells was evaluated in primary tumors using immunohistochemical staining...
February 28, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28239053/transforming-growth-factor-beta-and-forkhead-box-o-transcription-factors-as-cardiac-fibroblast-regulators
#12
Ignacio Norambuena-Soto, Constanza Núñez-Soto, Fernanda Sanhueza-Olivares, Nicole Cancino-Arenas, David Mondaca-Ruff, Raul Vivar, Guillermo Díaz-Araya, Rosemarie Mellado, Mario Chiong
Fibroblasts play several homeostatic roles, including electrical coupling, paracrine signaling and tissue repair after injury. Fibroblasts have low secretory activity. However, in response to injury, they differentiate to myofibroblasts. These cells have an increased extracellular matrix synthesis and secretion, including collagen fibers, providing stiffness to the tissue. In pathological conditions myofibroblasts became resistant to apoptosis, remaining in the tissue, causing excessive extracellular matrix secretion and deposition, which contributes to the progressive tissue remodeling...
February 24, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28216517/simultaneous-resection-for-colorectal-cancer-with-synchronous-liver-metastases-is-a-safe-procedure-outcomes-at-a-single-center-in-turkey
#13
Ender Dulundu, Wafi Attaallah, Metin Tilki, Cumhur Yegen, Safak Coskun, Mumin Coskun, Aylin Erdim, Eda Tanrikulu, Samet Yardimci, Omer Gunal
The optimal surgical strategy for treating colorectal cancer with synchronous liver metastases is subject to debate. The current study sought to evaluate the outcomes of simultaneous colorectal cancer and liver metastases resection in a single center. Prospectively collected data on all patients with synchronous colorectal liver metastases who underwent simultaneous resection with curative intent were analyzed retrospectively. Patient outcomes were compared depending on the primary tumor location and type of liver resection (major or minor)...
February 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250341/china-is-closely-monitoring-an-increase-in-infection-with-avian-influenza-a-h7n9-virus
#14
Qi Tang, Meiying Shao, Lingzhong Xu
The fifth outbreak of human infection with avian influenza A (H7N9) virus has struck far and wide in China. The number of cases of infection with the avian influenza A (H7N9) suddenly increased in 2013-2014, but the number of cases reported this winter has exceeded the number reported in all previous seasons. Given this situation, the National Health and Family Planning Commission issued updated Chinese guidelines (2017 version) on diagnosis and treatment of infection with the avian influenza A (H7N9) virus on January 24, 2017...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28250340/global-concern-regarding-the-fifth-epidemic-of-human-infection-with-avian-influenza-a-h7n9-virus-in-china
#15
Yinzhong Shen, Hongzhou Lu
Since the first outbreak of human infection with avian influenza A (H7N9) virus was identified in 2013, five seasonal outbreaks have occurred in China. The fifth outbreak started earlier than usual. A sudden increase in cases of human infection with avian influenza A (H7N9) virus has been reported in China since September 2016, and the number of cases reported in this season is exceeding that reported in previous seasons. This increase in the number of new cases of H7N9 infection has caused domestic and international concern...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28190795/progress-in-understanding-the-molecular-functions-of-ddx3y-dby-in-male-germ-cell-development-and-maintenance
#16
REVIEW
Alexei A Kotov, Oxana M Olenkina, Baira K Godneeva, Vladimir E Adashev, Ludmila V Olenina
Human DDX3 paralogs are housed on the X chromosome (DDX3X) as well as in the non- recombining region Yq11 of the Y-chromosome (DDX3Y or DBY). A gene encoding RNA helicase DDX3Y is located in the AZoospermia Factor a (AZFa) region of the Y-chromosome and expressed only in male germ cells. Deletions encompassing the DDX3Y gene lead to azoospermia and cause Sertoli Cell-Only Syndrome (SCOS) in humans. SCOS is characterized by a complete germ cell lack with preservation of somatic Sertoli cells. This review summarizes current advances in the study of DDX3Y functions in maintenance and development of early male germ cells...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28179601/regulation-of-ras-signaling-and-function-by-plasma-membrane-microdomains
#17
REVIEW
Lawrence E Goldfinger, James V Michael
Together H-, N- and KRAS mutations are major contributors to ~30% of all human cancers. Thus, Ras inhibition remains an important anti-cancer strategy. The molecular mechanisms of isotypic Ras oncogenesis are still not completely understood. Monopharmacological therapeutics have not been successful in the clinic. These disappointing outcomes have led to attempts to target elements downstream of Ras, mainly targeting either the Phosphatidylinositol 3-Kinase (PI3K) or Mitogen-Activated Protein Kinase (MAPK) pathways...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28179600/an-ethanol-extract-of-aster-yomena-kitam-honda-inhibits-lipopolysaccharide-induced-inflammatory-responses-in-murine-raw-264-7-macrophages
#18
Hye-Joo Kang, Ji-Suk Jeong, No-Jin Park, Geun-Bae Go, Sung Ok Kim, Cheol Park, Byung Woo Kim, Su-Hyun Hong, Yung Hyun Choi
Aster yomena (Kitam.) Honda has been widely used as a traditional herbal medicine for centuries to treat cough, asthma, insect bites, etc. Recent reports indicate that A. yomena possesses a wide spectrum of pharmacological activities; however, few experiments have described its anti-inflammatory properties. The present study examined the anti-inflammatory effects of an ethanol extract of A. yomena leaves (EEAY) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. Treatment with EEAY significantly reduced the secretion of pro-inflammatory molecules, such as nitric oxide and interleukin-1β, in LPS-stimulated RAW 264...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28179599/the-immune-dysfunction-in-ankylosing-spondylitis-patients
#19
Zhongliang Duan, Yuyan Gui, Cui Li, Jing Lin, Hans-Jürgen Gober, Juanxiu Qin, Dajin Li, Ling Wang
Ankylosing spondylitis (AS) is a spinal arthritic disease that is often associated with human leukocyte antigen (HLA)-B27, while only part of HLA-B27 carriers become AS patients. T cells have been reported to play an important role in the pathology of AS. T-cell immunoglobulin and mucin-domain-containing molecule 3 (Tim-3) and programmed death-1 (PD-1) have been known to negatively regulate the immune response. In this study, we used flow cytometry to analyze the immunological differences of peripheral bloodfrom 21 patients with AS, 22 cases who didn't have AS but were found to be HLA-B27 positive (HLA-B27+ group), and 16 normal healthy individuals (Healthy group)...
March 22, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28154340/yangjing-capsule-extract-promotes-proliferation-of-gc-1-spg-cells-via-up-regulated-pou3f1-pathway
#20
Baofang Jin, Bin Cai, Dalin Sun, Xindong Zhang, Yugui Cui, Weimin Deng, Chao Gao
As is similar to glial cell line-derived neurotrophic factor (GDNF), the Yangjing Capsule (YC) extract could also lead to proliferation of spermatogonial stem cells (SSCs) by stimulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway; however, the regulatory effect of YC extract on the expression of POU3F1 still remains unknown. The objective of this study is to determine whether the transcription factor POU3F1 is up-regulated by YC extract through the PI3K/AKT signaling pathway to regulate SSCs survival and proliferation...
March 22, 2017: Bioscience Trends
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