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Clinical Lipidology

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https://www.readbyqxmd.com/read/27066111/effects-of-armolipid-plus-on-small-dense-ldl-particles-in-a-sample-of-patients-affected-by-familial-combined-hyperlipidemia
#1
Marco Gentile, Ilenia Calcaterra, Alfonso Strazzullo, Carmen Pagano, Delia Pacioni, Enza Speranza, Paolo Rubba, Gennaro Marotta
AIM: The aim of this study was to test small dense LDL changes with Armolipid Plus treatment in patients with familial combined hyperlipidemia (FCHL). METHODS: After 4 weeks, 30 patients with FCHL were included in an 8-week, randomized, double-blind study and were taking, in addition to the standard diet, either placebo or Armolipid Plus. RESULTS: The placebo group showed no statistically significant differences in the studied parameters; instead, in the Armolipid Plus group, statistically significant reduction differences were detected in BMI (p = 0...
December 2015: Clinical Lipidology
https://www.readbyqxmd.com/read/26413163/management-of-lipoprotein-x-and-its-complications-in-a-patient-with-primary-sclerosing-cholangitis
#2
Eric J Brandt, Shane M Regnier, Edward Ky Leung, Sharon H Chou, Beverly W Baron, Helen S Te, Michael H Davidson, Robert M Sargis
Lipoprotein X (LpX) is an abnormal lipoprotein found in conditions such as lecithin:cholesterol acyltransferase deficiency and cholestatic states (e.g., primary biliary cirrhosis and primary sclerosing cholangitis). Management of severe hypercholesterolemia due to LpX with drugs and physical removal methods is not well established in the literature. A case is discussed of a 51-year-old woman who presented with multiple electrolyte abnormalities, xanthomas and neuropathy found to be secondary to LpX in the setting of primary sclerosing cholangitis...
August 1, 2015: Clinical Lipidology
https://www.readbyqxmd.com/read/27110290/the-potential-of-apolipoprotein-mimetic-peptides-in-the-treatment-of-atherosclerosis
#3
Luke J Leman
No abstract text is available yet for this article.
June 2015: Clinical Lipidology
https://www.readbyqxmd.com/read/26257830/an-update-on-testosterone-hdl-and-cardiovascular-risk-in-men
#4
Arthi Thirumalai, Katya B Rubinow, Stephanie T Page
Testosterone prescriptions have risen steadily and sharply in the USA despite a lack of clear understanding of the relationship between androgens and cardiovascular disease. In men with increasing age, testosterone levels decline and cardiovascular disease risk goes up. Ties between hypogonadism and cardiovascular disease are suggested by observational data, yet therapy with testosterone replacement has not been shown to mitigate that risk. To the contrary, recent literature has raised concern for increased cardiovascular disease in certain groups of men receiving testosterone therapy...
2015: Clinical Lipidology
https://www.readbyqxmd.com/read/26005496/lipoprotein-effects-of-incretin-analogs-and-dipeptidyl-peptidase-4-inhibitors
#5
Jixin Zhong, Andrei Maiseyeu, Sanjay Rajagopalan
Elevated post-prandial lipoprotein levels are common in patients with type 2 diabetes. Post-prandial lipoprotein alterations in type 2 diabetics are widely believed to drive inflammation and are considered a major risk factor for cardiovascular disease in diabetic patients. The incretins glucagon like peptide-1 (GLP-1) and glucose insulinotropic peptide (GIP) modulate post-prandial lipoproteins through a multitude of pathways that are independent of insulin and weight loss. Evidence from both animal models and humans seems to suggest an important effect on triglyceride rich lipoproteins (Apo48 containing) with little to no effects on other lipoproteins at least in humans...
2015: Clinical Lipidology
https://www.readbyqxmd.com/read/25937835/novel-method-for-reducing-plasma-cholesterol-a-ligand-replacement-therapy
#6
G M Anantharamaiah, Dennis Goldberg
Despite wide use of statins, significant cardiovascular disease risk persists. High-density lipoprotein based therapy has not yielded any positive results in combating this disease. Newer methods to rapidly decrease plasma cholesterol are much needed. While apolipoprotein B is a ligand for low-density lipoprotein receptor, which clears low-density lipoprotein cholesterol in a highly regulated pathway, apolipoprotein E (apoE) is a ligand for clearing other apolipoprotein B containing atherogenic lipoproteins via an alternate receptor pathway, especially the heparin sulfate proteoglycans on the liver cell surface...
January 1, 2015: Clinical Lipidology
https://www.readbyqxmd.com/read/25750665/harnessing-the-power-of-yeast-to-elucidate-the-role-of-sphingolipids-in-metabolic-and-signaling-processes-pertinent-to-psychiatric-disorders
#7
Shyamalagauri Jadhav, Miriam L Greenberg
The development of therapies for neuropsychiatric disorders is hampered by the lack of understanding of the mechanisms underlying their pathologies. While aberrant sphingolipid metabolism is associated with psychiatric illness, the role of sphingolipids in these disorders is not understood. The genetically tractable yeast model can be exploited in order to elucidate the cellular consequences of sphingolipid perturbation. Hypotheses generated from studies in yeast and tested in mammalian cells may contribute to our understanding of the role of sphingolipids in psychiatric disorders and to the development of new treatments...
November 1, 2014: Clinical Lipidology
https://www.readbyqxmd.com/read/25774225/cpt1a-the-future-of-heart-disease-detection-and-personalized-medicine
#8
M Ryan Irvin, Stella Aslibekyan, Bertha Hidalgo, Donna Arnett
No abstract text is available yet for this article.
2014: Clinical Lipidology
https://www.readbyqxmd.com/read/25705263/the-mutual-interplay-of-lipid-metabolism-and-the-cells-of-the-immune-system-in-relation-to-atherosclerosis
#9
Godfrey S Getz, Catherine A Reardon
Atherosclerosis is a chronic inflammation in the arterial wall involving cells of the innate and adaptive immune system that is promoted by hyperlipidemia. In addition, the immune system can influence lipids and lipoprotein levels and cellular lipid homeostasis can influence the level and function of the immune cells. We will review the effects of manipulation of adaptive immune cells and immune cell products on lipids and lipoproteins, focusing mainly on studies performed in murine models of atherosclerosis...
2014: Clinical Lipidology
https://www.readbyqxmd.com/read/25632306/the-interaction-between-metabolism-cancer-and-cardiovascular-disease-connected-by-27-hydroxycholesterol
#10
Wan-Ru Lee, Tomonori Ishikawa, Michihisa Umetani
Oxysterols are metabolites of cholesterol that are produced in liver and other peripheral tissues as a means to eliminate cholesterol to bile acid. Recent studies have revealed that the most abundant circulating oxysterol 27-hydroxycholesterol (27HC) is the first identified endogenous selective estrogen receptor modulator. 27HC levels correlate well with that of cholesterol, and also rise progressively with age. 27HC affects estrogen receptor function by the antagonism of estrogen action and also by the direct modulation of the receptor function, and similar to estrogen/estrogen receptors, 27HC has many actions in various tissues...
2014: Clinical Lipidology
https://www.readbyqxmd.com/read/25374625/monogenic-causes-of-elevated-hdl-cholesterol-and-implications-for-development-of-new-therapeutics
#11
Daniel B Larach, Marina Cuchel, Daniel J Rader
Identification of the CETP, LIPG (encoding endothelial lipase) and APOC3 genes, and ana lysis of rare genetic variants in them, have allowed researchers to increase understanding of HDL metabolism significantly. However, development of cardiovascular risk-reducing therapeutics targeting the proteins encoded by these genes has been less straightforward. The failure of two CETP inhibitors is complex but illustrates a possible over-reliance on HDL cholesterol as a marker of therapeutic efficacy. The case of endothelial lipase exemplifies the importance of utilizing population-wide genetic studies of rare variants in potential therapeutic targets to gain information on cardiovascular disease end points...
December 2013: Clinical Lipidology
https://www.readbyqxmd.com/read/24533033/lipid-signals-and-insulin-resistance
#12
Chongben Zhang, Eric L Klett, Rosalind A Coleman
The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intolerance, dyslipidemia and hypertension, is a major risk factor for cardiovascular disease. Insulin resistance has been proposed to be the common feature that links obesity to the metabolic syndrome, but the mechanism remains obscure. Although the excess content of triacylglycerol in muscle and liver is highly associated with insulin resistance in these tissues, triacylglycerol itself is not causal but merely a marker...
December 2013: Clinical Lipidology
https://www.readbyqxmd.com/read/25067958/setting-the-course-for-apoaii-a-port-in-sight
#13
Henry J Pownall, Baiba K Gillard, Antonio M Gotto
ApoAII, the second most abundant protein of the human plasma HDLs, was discovered nearly 50 years ago. Over the subsequent years, nearly 2000 studies - epidemiological, cell-based, biochemical, mouse and human - have attempted to unravel its role in human lipid metabolism. On the basis of these studies, apoAII has been described as an activator and inhibitor of various plasma activities, and as both pro- and anti-atherogenic. Here, we summarize the studies of apoAII, use the preponderance of evidence to propose that the apoAII compass can be reset towards an antiatherogenic course, and suggest ways to stay the course...
October 2013: Clinical Lipidology
https://www.readbyqxmd.com/read/26405460/oxidized-metabolites-of-linoleic-acid-as-biomarkers-of-liver-injury-in-nonalcoholic-steatohepatitis
#14
Nicola Santoro, Sonia Caprio, Ariel E Feldstein
The rising prevalence of obesity in the last few decades has been accompanied by an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of liver pathology from isolated hepatic steatosis to steatohepatitis and advanced fibrosis. Dietary habits characterized by consumption of high-caloric, lipid-rich diets play a major role in the development of NAFLD. Recent studies have uncovered the importance of certain components of the diet. In this review, we will focus on the growing evidence for a central role of n-6 polyunsaturated fatty acids...
August 1, 2013: Clinical Lipidology
https://www.readbyqxmd.com/read/24409204/regulating-intestinal-function-to-reduce-atherogenic-lipoproteins
#15
M Mahmood Hussain, Tung Ming Leung, Liye Zhou, Sarah Abu-Merhi
Significant knowledge regarding different molecules involved in the transport of dietary fat into the circulation has been garnered. Studies point to the possibility that accumulation of intestine-derived lipoproteins in the plasma could contribute to atherosclerosis. This article provides a brief overview of dietary lipid metabolism and studies in mice supporting the hypothesis that intestinal lipoproteins contribute to atherosclerosis. Deficiencies in lipoprotein lipase and Gpihbp1, and overexpression of heparanse in mice, are associated with increases in atherosclerosis, suggesting that defects in catabolism of larger lipoproteins in the plasma contribute to atherosclerosis...
August 1, 2013: Clinical Lipidology
https://www.readbyqxmd.com/read/23646066/examining-the-role-of-lipid-mediators-in-diabetic-retinopathy
#16
Julia V Busik, Walter J Esselman, Gavin E Reid
Diabetic retinopathy is the most disabling complication of diabetes, affecting 65% of patients after 10 years of the disease. Current treatment options for diabetic retinopathy are highly invasive and fall short of complete amelioration of the disease. Understanding the pathogenesis of diabetic retinopathy is critical to the development of more effective treatment options. Diabetic hyperglycemia and dyslipidemia are the main metabolic insults that affect retinal degeneration in diabetes. Although the role of hyperglycemia in inducing diabetic retinopathy has been studied in detail, much less attention has been paid to dyslipidemia...
December 1, 2012: Clinical Lipidology
https://www.readbyqxmd.com/read/23630545/mechanisms-of-oxysterol-induced-disease-insights-from-the-biliary-system
#17
Rahul Kuver
Oxysterols are oxidized species of cholesterol that are derived from exogenous (e.g. dietary) and endogenous (in vivo) sources. Oxysterols play critical roles in normal physiologic functions as well as in pathophysiologic processes in a variety of organ systems. This review provides an overview of oxysterol biology from the vantage point of the biliary system. Several oxysterols have been identified in human bile in the context of biliary tract infection and inflammation. This finding has led to investigations regarding the potential pathophysiologic significance of biliary oxysterols in diseases affecting the biliary system, with an emphasis on cholangiocarcinoma...
October 1, 2012: Clinical Lipidology
https://www.readbyqxmd.com/read/23606909/could-plasma-sphingolipids-be-diagnostic-or-prognostic-biomarkers-for-alzheimer-s-disease
#18
Michelle M Mielke, Norman J Haughey
Understanding the etiopathological processes of Alzheimer's disease (AD) in the preclinical and early clinical stages will be important in developing new therapeutic targets and biomarkers. There is growing consensus that nonamyloid targets will be necessary to reverse or slow AD progression. Lipidomic, metabolomic and targeted approaches have identified pathways and products of sphingolipid metabolism that are altered early in the course of AD and contribute to the neuropathological alterations associated with AD, including amyloid-β production, tau formation and neurodegeneration...
October 2012: Clinical Lipidology
https://www.readbyqxmd.com/read/25379057/testosterone-hdl-and-cardiovascular-risk-in-men-the-jury-is-still-out
#19
Katya B Rubinow, Stephanie T Page
"Even when reductions in HDL-cholesterol are observed as a consequence of androgen therapy, the implications for cardiovascular risk modification remain highly uncertain."
August 1, 2012: Clinical Lipidology
https://www.readbyqxmd.com/read/23136583/lipoprotein-a-and-cardiovascular-disease-in-diabetic-patients
#20
Qibin Qi, Lu Qi
Lipoprotein(a) (Lp[a]) is a LDL-like particle consisting of an ApoA moiety linked to one molecule of ApoB(100). Recent data from large-scale prospective studies and genetic association studies provide highly suggestive evidence for a potentially causal role of Lp(a) in affecting risk of cardiovascular disease (CVD) in general populations. Patients with Type 2 diabetes display clustered metabolic abnormalities and elevated risk of CVD. Lower plasma Lp(a) levels were observed in diabetic patients in several recent studies...
August 2012: Clinical Lipidology
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