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Gulf Journal of Oncology

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https://www.readbyqxmd.com/read/28272009/neoadjuvant-chemotherapy-a-new-standard-for-muscle-invasive-bladder-cancer
#1
Nabil Ismaili
Bladder cancer is the seventh most common cancer and the ninth most common cause of cancer deaths for men worldwide. Cystectomy with pelvic lymph nodes dissection is the standard local treatment of muscle invasive bladder cancer (MIBC) (T2-T4). In the last decade, the management of MIBC had become multidisciplinary involving peri-operative chemotherapy (neo- or adjuvant chemotherapy). Randomized trials and meta-analyses confirmed the survival benefit of neoadjuvant chemotherapy before local treatment (surgery and/or radiotherapy)...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272008/an-expansile-well-defined-radiolucency-in-anterior-mandible-case-presentation-with-treatment-approach-and-literature-update
#2
Shelly Arora, Aadithya B Urs, Zainab Choudhary
A 15-year-old Indian male patient presented with a history of pain and swelling in left mandible. Imaging studies revealed a well-defined unilocular radiolucency in the body of the mandible. Patient also gave the past history of the surgery of the jaws, which was histopathologically diagnosed as dentigerous cyst. Following this patient underwent incisional biopsy and later excisional biopsy. The histopathologic diagnosis for incisional biopsy was unicystic ameloblastoma but final diagnosis was dentinogenic ghost cell tumor for the excised tissue...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272007/management-of-hard-palatine-fistula-caused-by-granulocytic-sarcoma-case-report
#3
Rasha Aboelhassan, Howayda Abdel Ali, Asmaa Mohammed, Ahmed Mousa, Mohamed Elsayed Hassan, Mohamed Abdel Moaty Samra, Raafat Abdel Fattah
Granulocytic Sarcoma (GS) is a rare condition with a wide list of differential diagnosis and debatable guidelines of treatment in different cancer centers. Most of literature recommended systemic chemotherapy with or without radiation therapy and small role of surgery. One of the rarest sites for myeloid sarcoma is hard palate, which usually worsen the quality of life of the patient due to difficulty in feeding, drinking and speaking. We are reporting a case of hard palatine fistula caused by granulocytic sarcoma, in which we tried to get local control of disease with 3 dimension conformal radiation therapy 3DCRT and surgery with systemic control with chemotherapy using recommendation of multidisciplinary team and targeting mainly patient quality of life...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272006/solitary-metastasis-of-clear-renal-cell-carcinoma-to-thyroid-gland-three-reported-cases-with-review-of-the-literature
#4
Jaromir Astl, Abdulrahman Ali Bahannan, Jaroslava Dušková, Z Novák, P Vlcek, Jan Betka
Metastasis to the head and neck and more specifically to the thyroid gland from distant primary tumors is less common in comparison to the local regional metastasis of squamous cell carcinomas of the upper aero-digestive tract. Preoperative diagnosis of these cases can be difficult. The authors present three cases with distant solitary metastases of clear renal cell carcinoma to the thyroid gland with ambiguous mechanism of tumor spread to the thyroid. Solitary metastases of clear renal cell carcinomas are an uncommon variant of metastasis of this tumor and may imitate thyroid well differentiated carcinoma which most commonly affects the thyroid gland...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272005/bilateral-breast-cancer-after-prophylactic-bilateral-pulmonary-irradiation
#5
Hamrouni A El Meddeb, Jebsi M Chehata, S Kanoun, C Rancoule, J B Guy, N Magne, N Bouaouina
The purpose of this article is to report a new case of a probably radio-induced bilateral breast cancer occurred after prophylactic bilateral pulmonary irradiation in the treatment of osteosarcoma. A 42-year-old woman, treated at the age of 12 years for osteosarcoma at the right lower limb with chemotherapy (methotrexate, adriamycin and cisplatin) followed by non-conservative surgery and adjuvant radiotherapy. Eighteen years after, she developed her first breast cancer, and five years later, her second contralateral breast cancer...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272004/surgical-outcomes-post-neoadjuvant-chemotherapy-in-stage-iv-cancers-of-oral-cavity
#6
(no author information available yet)
AIM: To know the effect of neoadjuvant chemotherapy on surgical outcomes (R1 resections, post-operative complications, recurrence and follow up) in Stage IV borderline operable cancers of oral cavity. MATERIALS AND METHODS: Patients in group A (n=45) were those who were referred for neoadjuvant chemotherapy (NACT) with an intention to operate at a later date. These were compared with 45 patients of group B who were operated upfront. All 90 patients have stage IV squamous cell carcinoma of oral cavity...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272003/assessment-of-tumor-cell-cannibalism-as-a-predictor-of-oral-squamous-cell-carcinoma-a-histopathologic-correlation
#7
Megha Jain, Swati Saawarn, Anish Gupta, Sahana Ashok, Shubhangi Mhaske, Samark Khan, Manish Jain
AIM: Cellular cannibalism is defined as the ability of a cell to engulf another cell of its own type or any other. It has been recognized in various malignancies and is linked well with the aggressiveness, degree of anaplasia, invasiveness and metastatic potential. Literature search fetched up very few studies related to the presence and significance of cannibalism with respect to Oral squamous cell carcinoma [OSCC]. The present study was aimed to detect tumor cell cannibalism in OSCC and to validate its role as a prognosticator of OSCC in relation to metastasis and degree of differentiation...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272002/the-possible-role-of-diabetes-in-the-etiology-of-laryngeal-cancer
#8
Roberto Menicagli, Gianni Bolla, Laura Menigcali, Anastassia Esseridou
BACKGROUND: Laryngeal cancer and oral cancer are not always correlated with genetic mutations, HPV infection, smoking, and alcohol abuse. In the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. The aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer. METHODS: A questionnaire was given to a group of ninety laryngectomees to verify if these patients have presented diabetes and xerostomia before surgery...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272001/symptom-prevalence-of-patients-with-cancer-in-a-tertiary-cancer-center-in-jordan
#9
Alia Alawneh, Huda Anshasi, Ghaleb Khirfan, Hesham Yaseen, Anood Quran
BACKGROUND: Prevalence of symptoms experienced by patients with cancer was studied in different parts of the world. In Jordan, to the best of our knowledge, there is no published data on the prevalence of symptoms among patients with cancer. The aim of this study is to estimate the prevalence of symptoms among patients with cancer in Jordan. METHOD: This was a secondary analysis of crosssectional survey that evaluate the psychometric properties of the Arabic version of the European Organization for Research and Treatment of Cancer Quality of Life 15 items Questionnaire for Palliative Care (EORTC QLQ-C15-PAL) among patients admitted to a tertiary cancer center in Jordan...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28272000/study-of-serum-carcinoembryonic-antigen-s-profile-for-breast-cancer-in-western-algeria-100-cases
#10
Zenib Tahari, Asmahane Medjdoub, Tewfik Sahraoui, Leila Belhabri, Fatima Zohra El Kebir
BACKGROUND: Breast cancer is the most common cancer in women worldwide. Biology contributes to the early diagnosis and monitoring of breast cancer with several categories of markers such as prognostic markers (ER, PR, HER2), proliferative markers (Ki67), and tumor markers such as CEA and CA 15-3. CEA can be detected at a high concentration in serum of patients with malignant tumors. AIM: The aim of our study was to evaluate the concentrations of CEA in serum of women with breast cancer and to verify the existence of a possible link between the average rates of CEA and SBR grade...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28271999/postoperative-radiotherapy-in-salivary-gland-carcinoma-a-single-institution-experience
#11
Öztun Temelli, Ersoy Kekilli, Ahmet Kizilay
BACKGROUND: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. MATERIALS AND METHODS: The medical records of 30 patients with salivary gland tumors operated on and referred to our clinic for adjuvant RT between January 2004 and June 2015 were retrospectively evaluated...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28271998/myeloid-sarcoma-as-the-first-sign-of-progression-of-chronic-myeloid-leukemia-in-medullary-chronic-phase-experience-from-a-tertiary-cancer-centre-in-southern-india
#12
(no author information available yet)
INTRODUCTION: Myeloid sarcoma (MS) in chronic myeloid leukemia (CML) is a rare entity which is suggestive of advanced phase of the disease and poorer outcomes. There is little data in literature available regarding its presentation in medullary chronic phase (CP) as well as outcomes in the era of tyrosine kinase inhibitors (TKI) and needs to be carefully evaluated as it can present the first sign of progressive disease before haematological progression. METHODS: We identified cases of MS presenting with medullary CML-CP from January 2002 to December 2015...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28271997/a-retrospective-study-of-clinical-profile-and-long-term-outcome-to-imatinib-mesylate-alone-in-childhood-chronic-myeloid-leukemia-in-chronic-phase
#13
(no author information available yet)
OBJECTIVE: Chronic myeloid leukemia (CML) is relatively rare malignancy in childhood. There are limited studies of use of Imatinib Mesylate (IM) alone in management of CML in this age group. METHOD: We retrospectively analyzed the outcome of 30 consecutive children with CML chronic phase treated with IM alone. RESULTS: The median age at the time of diagnosis was 11 years with male preponderance. Asthenia and abdominal discomfort due to splenomegaly were the most common presenting features and splenomegaly a dominant sign...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28271996/multi-detector-computed-tomography-mdct-findings-of-seven-cases-with-spontaneous-regression-of-hepatocellular-carcinoma
#14
Adel El-Badrawy
PURPOSE: To review Multi-detector CT findings of seven cases with spontaneous regression of hepatocellular carcinomas (HCC). MATERIALS AND METHODS: This retrospective study included 7 patients confirmed with diagnosis of HCC. Triphasic CT scan using multi-detector CT scanner was done for all patients. They were 2 women and 5 men. 1st patient presented with metastatic HCC underwent fine needle aspiration cytology (FNAC) from vertebral metastasis. 2nd patient underwent only one session of trans-arterial chemo-lipidol...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191814/the-pathophysiologic-basis-of-anaemia-in-patients-with-malignant-diseases
#15
Umma A Ibrahim, Aminu A Yusuf, Sagir G Ahmed
Cancer patients frequently present with anaemia that may result from the direct or indirect effects of the tumor or its treatment. Anaemia is an independent adverse prognostic factor that exerts negative influence on quality of life and survival of cancer patients. Anaemia in malignant disorders often arises from an interplay of multiple aetiological and pathophysiologic mechanisms. Understanding these mechanisms will help the oncologist identify and treat specific causes of the anaemia thereby minimizing the use of blood transfusion, which is associated with many adverse effects...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191813/acute-lymphoblastic-leukemia-mimicking-wilms-tumor-at-presentation
#16
Amitabh Singh, Anirban Mandal, Vijay Guru, Rachna Seth
BACKGROUND: Acute lymphoblastic leukemia (ALL), the commonest malignancy of childhood, is known to manifest with a myriad of atypical presentations. Nephromegaly is a rare presentation of childhood ALL with hepatic mass being even rarer. CASE PRESENTATION: We present a 3 year-old child with unilateral renal mass and hepatic mass lesion with normal blood counts, initially suspected to have metastatic Wilms tumor based on clinical, radiological and WT1 positivity on immunocytochemistry of renal mass...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191812/moderately-differentiated-neuroendocrine-cell-carcinoma-of-the-vulva-a-case-report-and-review-of-the-literature
#17
Soheila Aminimoghaddam, A Maghsoudnia, S Shafiee
Primary vulvar neuroendocrine carcinoma are extremely rare. There have been few cases of these tumors most of which have been considered as Merkel cell carcinoma. This report describes a moderately differentiated neuroendocrine cell carcinoma that was not compatible to any of previously reported cases. The patient underwent left hemivulvectomy and bilateral inguinal lymph node dissection. Pathology examination revealed a 5×5 cm mass with no lymph node involvement. Post-op evaluation ruled out any regional and distant metastasis and thereby did not receive chemotherapy or radiotherapy...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191811/metastatic-ameloblastoma-to-brain-a-rare-entity
#18
Arif Sarmast, Khursheed Nayil-M, Rumana Makhdoomi, Azhar Butto, Altaf Ramzan
Ameloblastoma is a rare odontogenic tumor of the jaw. It is a benign neoplasm but local recurrence is common. Metastasis from this tumor is all the more rare. The commonest site for metastasis is lung. Brain is a very uncommon site of involvement. Overall prognosis is good. We hereby discuss ameloblastoma of lower jaw in a young adult which had metastasized to brain. Patient was operated for the metastatic lesion of brain and is doing well on follow-up.
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191810/gist-institutional-experience-at-srms-ims-india
#19
Shubhanshu Gupta, Keshri Amit, Ashish Gupta, Tanu Argawal
Gastro-Intestinal Stromal Tumors (GIST) is a malignant, non-epithelial, mesenchymal tumor of the digestive tract that is not uncommon in clinical practice nowadays; diagnosis being based upon immuno-histo-chemical analysis of the resected or biopsied (FNAC) specimen. Abdominal lump with or without intra-luminal bleed is a common mode of presentation. Early diagnosis and appropriate management with surgery and/or Imatinib therapy improves recurrence free survival and may impact overall survival. We present here our institutional experience of four patients, admitted in Onco-Surgery Dept...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191809/unusual-destruction-of-the-nasal-septum
#20
Tarek Assi, Elie El Rassy, Tania Moussa, Samer Tabchi, Ralph Chebib, Marwan Ghosn
Extranodal Natural Killer/T-cell lymphoma (ENKTL) is the most common cause of nasal cell lymphoma. It manifests by progressive destruction of the facial midline features with nasal obstruction and local destruction of soft tissue. Therefore, establishing the diagnosis of this disease tends to be difficult. This is attributed to an extensive differential diagnosis of infectious, autoimmune, neoplastic and inflammatory etiologies. We herein report the case of a 63-year-old female who presented to our department for persistent nasal congestion resistant to symptomatic treatment that was found to have an ENKTL...
September 2016: Gulf Journal of Oncology
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