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Gulf Journal of Oncology

L El Amarti, I Elghissassi, M Layachi, H Mrabti, H Errihani
Lung cancer is the leading cause of cancer-related mortality worldwide owing to its advanced-stage at the time of diagnosis. The majority of patients will require a second-line therapy after progression during first-line treatment. While treatment for NSCLC with EGFR mutation or EML4/ALK fusion, target therapy is the favored second-line therapy if not already used in first-line therapy, NSCLC with EGFR wild-type remains an unmet need and many oncologists favor cytotoxic therapy. Recently, a better understanding of lung cancer biology, with a better selection of patients based on histology, molecular biology and the identification of potential target antigens in the immune system have significantly improved patient outcome...
May 2016: Gulf Journal of Oncology
G Maresca, P S Wismayer
DNA methylation has been recognized as one of the most important epigenetic mechanisms regulating the expression and inhibition of genes giving rise to an organism's phenotype. It is hence of no surprise that when DNA methylation mechanisms are disrupted by intrinsic or extrinsic causes, the likelihood of tumourigenesis increases. Both hypermethylation and hypomethylation may predispose to cancer formation through aberrant inhibition or expression of particular genes and this is seen in different types of cancers, such as laryngeal squamous cell carcinoma and acute myeloid leukaemia...
May 2016: Gulf Journal of Oncology
R Benson, R Madan, P K Julka, G K Rath
PURPOSE: Metaplastic carcinoma of breast (MCB) is a rare histological subtype of breast carcinoma and accounts for less than 1 percent of the total breast cancer cases. Here we are reporting a series of seven patients of MCB from single institute along with review of literature. MATERIAL AND METHODS: Patients records from January 2008 to August 2014 were retrieved to search for MCB patients. A etrospective review was conducted to document the clinicopathological features, treatment and outcomes of these patients...
May 2016: Gulf Journal of Oncology
A Gupta, P Prakash, A Rattan, N Wadhwa, S Kumar, V Rathi
Malignant melanoma of the anorectum is a rare but highly aggressive tumor. We report our experience of anorectal melanoma in five patients. Of these, two have advanced disease, two had localized disease and one patient had florid systemic metastases with a history of hemorrhoidectomy one year prior. One patient whose metastatic workup was negative, expired on post-op day 15 of abdominoperineal resection due to unsuspected but florid cerebral metastases. Another patient with localized disease underwent an APR with curative resection and post-op whole body PET scan negative for occult or residual disease...
May 2016: Gulf Journal of Oncology
H R Kourie, J Antoun, F Bteich, A Jalkh, M Ghosn
Choroidal metastasis from prostate cancer is very rare and usually presents late during the disease. Since 2010, many new drugs were approved in the treatment of castrationresistant prostate cancer, including Abiraterone acetate. We report a case of bilateral choroidal metastases from prostate cancer 3 months after the initiation of Abiraterone. Abiraterone was not efficient in controlling the progression of the disease in this case, especially the choroidal metastasis. More case reports are essential in order to evaluate the role of Abiraterone in controlling choroidal metastases from prostate adenocarcinoma...
May 2016: Gulf Journal of Oncology
M Chisti, R Almasri, I Hamadah
BACKGROUND: Basal cell carcinoma (BCC) is the most common epithelial neoplasm of skin. Risk factors for the development of BCC include intermittent intense sun exposure, radiation therapy, family history of BCC, immune suppression and fair complexion, especially red hair. It can originate in scars like small pox, vaccination, chicken pox or surgical scars. OBJECTIVE AND CONCLUSION: We present a case of basal cell carcinoma arising in a leishmania scar on the nose, sixty years after the primary lesion...
May 2016: Gulf Journal of Oncology
S Usmani, M Oteifa, F Abu Huda, A Javaid, H G Amanguno, F Al Kandari
Intrathymic parathyroid adenoma is a rare cause of primary hyperparathyroidism. In this case, Tc-99m Sestamibi SPECT-CT successfully localized abnormal tracer uptake in the mediastinum with corresponding low density lesion on CT images suggestive of mediastinal parathyroid adenoma which late on confirmed on histopathology. After the median sternotomy a large intrathymic parathyroid adenoma was identified and excised. With the help of gamma probe the surgeons detect the lesion early and with more confidence as well as reducing the total operation time...
May 2016: Gulf Journal of Oncology
O M Zakaria, M Y I Daoud, S H Farrag, A S Mulhim
BACKGROUND: Management of Nephroblastoma (NB) remains a subject of debate despite the fact that it ranked first among primary childhood's renal neoplasm. We have previously discussed this issue 13, 14, yet, the sample size was limited. AIM: The aim of this study was to further evaluate the efficacy of initial surgery in the treatment of stage II and III pediatric NB as a part of the short administration schedule as in National Wilms' Tumor Study (NWTS)-4 and to evaluate its effectiveness compared to the long administration schedule...
May 2016: Gulf Journal of Oncology
C S Premalata, K Umadevi, K Shobha, M Anurekha, L Krishnamoorthy
AIM: The objective of this study was to evaluate the expression pattern of vascular endothelial growth factor A (VEGF A) in epithelial ovarian cancers (EOC) and to correlate the intensity of expression with morphologic types, histologic grade and clinical stage of the disease. METHODS: Tissue microarrays were constructed from paraffin blocks of 78 cases of EOC in duplicate. Immunohistochemical staining for VEGF A was carried out with mouse monoclonal antibody and the intensity was scored independently by two pathologists (CSP and MA)...
May 2016: Gulf Journal of Oncology
K Sitpura, E Salmo
Prostate cancer is considered as the second most frequently diagnosed malignancy and the sixth leading cause of cancer death in males. The quality of the prostate biopsy and its processing techniques may influence the outcome of the histopathological assessment which is the gold standard for cancer diagnosis. An audit of 240 prostate biopsies from 20 patients was conducted to compare the quality and length of tissue before and after the implementation of sponge embedding technique. The average length of prostatic biopsy before the procedure was 5...
May 2016: Gulf Journal of Oncology
P Kannan, A Mukherji, K Saravanan, K S Reddy, S Vivekanandam, C Shamsudheen, V Santhosh
OBJECTIVE: To assess the change in the quality of life (QOL) in Oropharyngeal, Laryngeal and Hypopharyngeal cancer patients treated with concomitant boost radiotherapy by Volumetric Intensity Modulated Arc Therapy (VMAT) technique. METHODS: Thirty patients with oropharynx, larynx or hypopharynx cancers of stage II to IVA were treated with an Accelerated fractionation schedule using Concomitant boost. The dose given was 1.8Gy/fraction daily, 5 days a week to the large field for 28 fractions and a daily concomitant boost of 1...
May 2016: Gulf Journal of Oncology
S Khan, Sma Feroz, M Jain, V Mathur, Sameera Khan
BACKGROUND: Cancer therapy couples with it a plethora of complications of short and long term effects which can be so distressing that patient may tolerate only lower less-effective doses of therapy, may postpone treatments or will discontinue treatment entirely. Fractionated dose of radiotherapy coupled with therapy induce local or systemic infections due to high cellular turnover rates of the oral mucosa, diverse and complex microflora and trauma to oral tissues. Several mucosal abnormalities often results in epithelial and glandular destruction and inflammation, which can be so devastating that it may cause atypical changes on the area exposed to radiation...
May 2016: Gulf Journal of Oncology
I Ali, N Alsbou, S Oyewale, J Jaskowiak, S Ahmad, O Algan
PURPOSE: To quantify the variations in the length and position of fiducial markers induced by motion in axial (ACT), helical (HCT) and cone-beam CT (CBCT) imaging and associated uncertainty in image-guided radiotherapy (IGRT) by measurement and modeling. METHODS: A mobile thorax phantom containing markers of various lengths was imaged using ACT, HCT and CBCT imaging. The phantom was imaged while stationary and moving where it was moved sinusoidally with different motion amplitudes and frequency...
May 2016: Gulf Journal of Oncology
R Tanz, C El Mhadi, M Toreis, M R Khmamouch, T Mahfoud, A A Ali, H Errihani, M Ichou
BACKGROUND: Use of perioperative chemotherapy had significantly improved prognosis of localized gastric cancer. Two studies have validated this approach using cisplatin based chemotherapy despite important toxicities. We conducted this study with the aim to evaluate efficacy and toxicity of FOLFOX regimen in this setting. MATERIAL AND METHODS: This is a retrospective study including patients followed for gastric cancer in the Oncology Department of the military hospital Mohamed V in Rabat, Morocco over a period of 7 years from 2007 to 2013...
May 2016: Gulf Journal of Oncology
M W Hegazy, R Mahmood
PURPOSE: To evaluate the feasibility, efficacy and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer. METHODS AND MATERIALS: The current series of SHARP included six patients with localized prostate cancer treated with 36.25 Gy in 5 fractions by Cyber-knife. Non-coplanar conformal fields and daily stereotactic localization of implanted fiducials were used for treatment. Acute and Late Genitourinary (GU) and gastrointestinal (GI) toxicity were evaluated by Common Toxicity Criteria (CTC)...
May 2016: Gulf Journal of Oncology
S Rawat, H Srivastava, P Ahlawat, M Pal, G Gupta, D Chauhan, S Tandon, R Khurana
PURPOSE: To compare toxicity, compliance, and early response of weekly and 3-weekly cisplatin administration concurrent with radiotherapy as definitive treatment in locally advanced squamous cell carcinoma head and neck. MATERIALS AND METHODS: Patients with histologically proven stage III - IV B head and neck carcinoma presenting from June 2013 to March 2014 were randomly assigned to weekly (35 mg/m2, 6 cycles; arm A) and 3 weekly (100 mg/m2, 3 cycles; arm B) cisplatin with concurrent radiotherapy...
May 2016: Gulf Journal of Oncology
S Khan, M Jain, V Mathur, S M A Feroz
As early as the 19th century, inflammation has been perceived to have a link with cancer but this perception has waned through the passing of time. In recent years however a renewed interest on inflammation and cancer connection stemming from different lines of work has been evolved that leads to a generally-accepted paradigm. In the tumor microenvironment, smouldering inflammation contributes to the proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents...
January 2016: Gulf Journal of Oncology
R Makhdoomi, N Bashir, N Bhat, S Bashir, F Mustafa, A Aiman, A Charaki, S Hussain, S Shafi, S Baht, N Bashir, Z Zahir, P Shah
Gallbladder cancer is a highly aggressive malignancy that usually presents at an advanced incurable stage. It is the fifth most common gastro-intestinal tumor and leads to approximately 2800 deaths in United States annually. This was a retrospective study carried out in the Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, a 650-bed super speciality hospital in Kashmir valley. We reviewed the histopathological records of all the patients who were diagnosed as carcinoma gallbladder from Dec 2009-Dec 2013...
January 2016: Gulf Journal of Oncology
K Al-Qahtani
BACKGROUND: Mobile phones are integral part of the modern lifestyle. As they emit radio frequency electromagnetic field, their role in carcinogenesis needs to be ascertained. The goal of this study was to investigate the association between the use of cellular phones and the risk for parotid gland tumors. MATERIALS AND METHODS: A total of 26 patients diagnosed with parotid gland tumors and 61 healthy controls were enrolled through a hospital-based retrospective case-control study...
January 2016: Gulf Journal of Oncology
A El-Badrawy, A M Tawfiki, W Mahmoud, E Abdel-Salam, M M Taalab, O Farouk, Y Zakaria, A M Shebl, H El-Hadaad
OBJECTIVE: The aim of this study was to describe the triphasic multidetector CT (MDCT) finding of primary hepatic lymphoma (PHL). MATERIALS AND METHODS: This retrospective study included eighteen patients. Each patient presented with primary hepatobiliary lymphoma without associated lymphadenopathy or other visceral involvement. Triphasic CT scanning was performed on one of two systems (64 MD CT) in 12 patients and (6 MDCT) in 6 patients. All eighteen patients underwent ultrasound percutaneous trucut liver biopsy using 18-gauge biopsy needle...
January 2016: Gulf Journal of Oncology
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