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Nature Reviews. Urology

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https://www.readbyqxmd.com/read/29205203/bladder-cancer-genomics-of-noninvasive-disease
#1
Clemens Thoma
No abstract text is available yet for this article.
December 5, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29205202/prostate-cancer-stuck-in-the-middle-interstitial-genes-in-tmprss2-erg-fusion
#2
Louise Stone
No abstract text is available yet for this article.
December 5, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29205201/surgery-moving-towards-successful-penile-transplantation-programmes
#3
Jeffrey D Campbell, Arthur L Burnett
No abstract text is available yet for this article.
December 5, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29205200/immunotherapy-in-metastatic-urothelial-carcinoma-focus-on-immune-checkpoint-inhibition
#4
REVIEW
Arlene Siefker-Radtke, Brendan Curti
Immunotherapy has been used in localized urothelial carcinoma for decades, especially in the treatment of superficial disease, in which instillation of BCG is a commonly used treatment option. Clinical investigations based on new insights into the immunogenic potential of metastatic urothelial carcinoma have led to the accelerated FDA approval of the immune checkpoint inhibitors atezolizumab, nivolumab, durvalumab, avelumab, and pembrolizumab. Preliminary findings suggest additional benefits of combinations of immunotherapeutic agents as a future treatment approach in metastatic urothelial carcinoma...
December 5, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29182606/bladder-cancer-in-2017-advancing-care-through-genomics-and-immune-checkpoint-blockade
#5
Matthew D Galsky
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29182605/prostate-cancer-glycolysis-and-ar-expression-as-biomarkers
#6
Rebecca Kelsey
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29182604/prostate-cancer-h2a-zac-activates-neo-enhancers
#7
Clemens Thoma
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29182603/a-psychosocial-approach-to-female-genital-pain
#8
REVIEW
Marieke Dewitte, Charmaine Borg, Lior Lowenstein
Genital pain is a prevalent, complex, and disabling health concern in women. Efforts to study this chronic pain condition have been complicated by the fact that genital pain is heterogeneous and exists at the intersection of different biopsychosocial disciplines. Thus, organization of theoretical ideas and empirical findings across research areas is required to improve our understanding of how biopsychosocial factors affect the development and maintenance of the pain, the reporting of symptoms, and the choice of treatment...
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29182602/utuc-in-2017-emerging-evidence-on-treating-upper-tract-urothelial-cancer
#9
Pietro Grande, Morgan Rouprêt
No abstract text is available yet for this article.
November 28, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29160866/prostate-cancer-a-nervous-disposition-the-angiometabolic-switch
#10
Louise Stone
No abstract text is available yet for this article.
November 21, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29160865/pain-long-term-outcomes-of-trmdsc-for-chronic-orchialgia
#11
Rebecca Kelsey
No abstract text is available yet for this article.
November 21, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133941/bladder-cancer-context-is-key-dual-roles-of-angptl4
#12
Louise Stone
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133940/stimulators-and-activators-of-soluble-guanylate-cyclase-for-urogenital-disorders
#13
REVIEW
Fabiola Z Mónica, Edson Antunes
Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions that affect millions of people worldwide. LUTS have a profound effect on quality of life and are a considerable cost to health care systems. In men specifically, BPH commonly leads to LUTS. Clinical studies also show an association of LUTS with erectile dysfunction (ED). Nitric oxide (NO) has long been recognized as an important nonadrenergic, noncholinergic (NANC) transmitter in bladder, urethra, prostate, and corpus cavernosum smooth muscle...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133939/precision-medicine-for-urothelial-bladder-cancer-update-on-tumour-genomics-and-immunotherapy
#14
REVIEW
Kenneth M Felsenstein, Dan Theodorescu
Effective management of advanced urothelial bladder cancer is challenging. New discoveries that improve our understanding of molecular bladder cancer subtypes have revealed numerous potentially targetable genomic alterations and demonstrated the efficacy of treatments that harness the immune system. These findings have begun to change paradigms of bladder cancer therapy. For example, DNA repair pathway mutations in genes such as ERCC2, FANCC, ATM, RB1, and others can predict responses to neoadjuvant platinum-based chemotherapies and to targeted therapies on the basis of mutation status...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133938/prostate-cancer-response-prediction-with-hsd3b1
#15
Clemens Thoma
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133937/stones-predicting-stone-episodes-using-cystine-capacity
#16
Matthew Bultitude, Kay Thomas
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133936/the-rho-gtpase-signalling-pathway-in-urothelial-carcinoma
#17
REVIEW
Solomon L Woldu, Ryan C Hutchinson, Laura-Maria Krabbe, Oner Sanli, Vitaly Margulis
Urothelial carcinoma remains a clinical challenge: non-muscle-invasive disease has a high rate of recurrence and risk of progression, and outcomes for patients with advanced disease are poor, owing to a lack of effective systemic therapies. The Rho GTPase family of enzymes was first identified >30 years ago and contains >20 members, which are divided into eight subfamilies: Cdc42, Rac, Rho, RhoUV, RhoBTB, RhoDF, RhoH, and Rnd. Rho GTPases are molecular on-off switches, which are increasingly being understood to have a critical role in a number of cellular processes, including cell migration, cell polarity, cell adhesion, cell cycle progression, and regulation of the cytoskeleton...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133935/sacral-neuromodulation-and-alterations-in-brain-activity-discussing-discrepancies
#18
Bradley C Gill, Howard B Goldman
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133934/prostate-cancer-conserved-lipid-synthesis-drives-castration-resistance
#19
Annette Fenner
No abstract text is available yet for this article.
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29116259/prostate-cancer-brachytherapy-monotherapy-is-efficacious
#20
Clemens Thoma
No abstract text is available yet for this article.
November 8, 2017: Nature Reviews. Urology
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