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Nature Reviews. Urology

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https://www.readbyqxmd.com/read/29777192/hypoxia-related-gene-panel-is-prognostic
#1
Louise Stone
No abstract text is available yet for this article.
May 17, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29773859/surfaceome-profiling-for-nepc-target-antigens
#2
Annette Fenner
No abstract text is available yet for this article.
May 17, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29769644/translational-models-of-prostate-cancer-bone-metastasis
#3
REVIEW
Richard B Berish, Aymon N Ali, Patrick G Telmer, John A Ronald, Hon S Leong
Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to accurately recapitulate the spread of prostate cancer to bone - the most common site of metastasis - is critical to the development of novel metastasis-directed therapies. Several translational models of prostate cancer bone metastasis have been developed, including animal models, cell line injection models, 3D in vitro models, bone implant models, and patient-derived xenograft models. The use of these models has led to numerous advances in elucidating the molecular mechanisms of metastasis and innovations in targeted therapy...
May 16, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29769643/aptamer-effective-in-vivo
#4
Clemens Thoma
No abstract text is available yet for this article.
May 16, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29765147/systemic-treatments-for-high-risk-localized-prostate-cancer
#5
REVIEW
Géraldine Pignot, Denis Maillet, Emmanuel Gross, Philippe Barthelemy, Jean-Baptiste Beauval, Friederike Constans-Schlurmann, Yohann Loriot, Guillaume Ploussard, Paul Sargos, Marc-Olivier Timsit, Sébastien Vincendeau, Gilles Pasticier, Delphine Borchiellini
The majority of patients with prostate cancer who later develop lethal metastatic disease have high-risk localized disease at presentation, emphasizing the importance of effective treatment strategies at this stage. Multimodal treatment approaches that combine systemic and local therapies offer a promising strategy for improving the clinical outcomes of patients with high-risk localized prostate cancer. Combinations of neoadjuvant and adjuvant chemotherapy, hormonal therapy, or chemohormonal therapy are considered to be the standard of care in most solid tumours and should be investigated in the future for the treatment of prostate cancer to improve patient outcomes...
May 15, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29765146/do-dietary-calcium-and-vitamin-d-matter-in-men-with-prostate-cancer
#6
REVIEW
Thierry Capiod, Nicolas Barry Delongchamps, Natascha Pigat, Jean-Claude Souberbielle, Vincent Goffin
Active surveillance (AS) is an attractive alternative to immediate treatment for men with low-risk prostate cancer. Thus, the identification of environmental factors that promote the progression of indolent disease towards aggressive stages is critical to optimize clinical management. Epidemiological studies suggest that calcium-rich diets contribute to an increased risk of developing prostate cancer and that vitamin D reduces this risk. However, the potential effect of these nutrients on the progression of early-stage prostate tumours is uncertain, as studies in this setting are scarce and have not provided unambiguous conclusions...
May 15, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29765145/optimizing-radiotherapy-for-intermediate-risk-localized-disease
#7
Pirus Ghadjar, Thomas Wiegel
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29752463/personalization-of-prostate-cancer-therapy-through-phosphoproteomics
#8
REVIEW
Wei Yang, Michael R Freeman, Natasha Kyprianou
Castration-resistant prostate cancer (CRPC) remains incurable despite the approval of several new treatments. Identification of new biomarkers and therapeutic targets to enable personalization of CRPC therapy, with the aim of maximizing therapeutic responses and minimizing toxicity in patients, is urgently needed. Prostate cancer progression and therapeutic resistance are frequently driven by aberrantly activated kinase signalling pathways that are amenable to pharmacological inhibition. Personalized phosphoproteomics, which enables the analysis of signalling networks in individual tumours, is a promising approach to advance personalized therapy by discovering biomarkers of pathway activity and clinically actionable targets...
May 11, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29743669/controlling-mutational-chaos
#9
Clemens Thoma
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29743668/which-antibiotics-for-uti
#10
Louise Stone
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29740117/tracing-the-steps-of-cancer-evolution
#11
Conor A Bradley
No abstract text is available yet for this article.
May 8, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29740116/revisiting-5%C3%AE-reductase-inhibitors-and-the-risk-of-prostate-cancer
#12
Cindy H Chau, William D Figg
No abstract text is available yet for this article.
May 8, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29725126/in-the-bank-bladder-organoids-recapitulate-original-tumour
#13
Louise Stone
No abstract text is available yet for this article.
May 3, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29713007/historical-and-contemporary-perspectives-on-cribriform-morphology-in-prostate-cancer
#14
REVIEW
Matthew Truong, Thomas Frye, Edward Messing, Hiroshi Miyamoto
The Gleason scoring system is widely used for the grading and prognostication of prostate cancer. A Gleason pattern 4 subtype known as cribriform morphology has now been recognized as an aggressive and often lethal pattern of prostate cancer. The vast majority of published and ongoing prostate cancer studies still do not acknowledge the prognostic differences between various Gleason pattern 4 morphologies. As a result, current treatment recommendations are likely to be imprecise and not tailored towards patients who are most likely to die from the disease...
April 30, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29713006/macropinocytosis-for-proliferation
#15
Rebecca Kelsey
No abstract text is available yet for this article.
April 30, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29686373/ar-involved-in-sunitinib-resistance
#16
Louise Stone
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29674670/cryo-combo-augments-ici
#17
Annette Fenner
No abstract text is available yet for this article.
April 19, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29670181/regulation-of-masculinization-androgen-signalling-for-external-genitalia-development
#18
REVIEW
Shoko Matsushita, Kentaro Suzuki, Aki Murashima, Daiki Kajioka, Alvin Resultay Acebedo, Shinichi Miyagawa, Ryuma Haraguchi, Yukiko Ogino, Gen Yamada
The biology of masculinization is fundamentally important for understanding the embryonic developmental processes that are involved in the development of the male reproductive tract, external genitalia, and also the tumorigenesis of prostate cancer. The molecular mechanisms of masculinization are of interest to many researchers and clinicians involved in varied fields, including molecular developmental biology, cancer research, endocrinology, and urology. Androgen signalling is mediated by the nuclear androgen receptor, which has fundamental roles in masculinization during development...
April 18, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29666457/second-generation-antiandrogens-in-nonmetastatic-crpc
#19
Robert Chandler, Johann de Bono
No abstract text is available yet for this article.
April 17, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29662117/treating-vulvovaginal-symptoms
#20
Louise Stone
No abstract text is available yet for this article.
April 16, 2018: Nature Reviews. Urology
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