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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/29789704/single-cell-rna-sequencing-for-the-study-of-development-physiology-and-disease
#1
REVIEW
S Steven Potter
An ongoing technological revolution is continually improving our ability to carry out very high-resolution studies of gene expression patterns. Current technology enables the global gene expression profiles of single cells to be defined, facilitating dissection of heterogeneity in cell populations that was previously hidden. In contrast to gene expression studies that use bulk RNA samples and provide only a virtual average of the diverse constituent cells, single-cell studies enable the molecular distinction of all cell types within a complex population mix, such as a tumour or developing organ...
May 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29789703/renal-il-17-activity-in-candidiasis
#2
Ellen F Carney
No abstract text is available yet for this article.
May 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29777155/dnajb11-another-player-in-adpkd
#3
Susan J Allison
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29760448/the-gut-microbiota-and-the-brain-gut-kidney-axis-in-hypertension-and-chronic-kidney-disease
#4
REVIEW
Tao Yang, Elaine M Richards, Carl J Pepine, Mohan K Raizada
Crosstalk between the gut microbiota and the host has attracted considerable attention owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly associated with hypertension and is characterized by immune dysregulation, metabolic disorder and sympathetic activation, which are all linked to gut dysbiosis and altered host-microbiota crosstalk. In this Review, we discuss the complex interplay between the brain, the gut, the microbiota and the kidney in CKD and hypertension and explain our brain-gut-kidney axis hypothesis for the pathogenesis of these diseases...
May 14, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29760447/the-role-of-platelets-in-acute-kidney-injury
#5
REVIEW
Marcel P B Jansen, Sandrine Florquin, Joris J T H Roelofs
Acute kidney injury (AKI), a major public health problem associated with high mortality and increased risk of progression towards end-stage renal disease, is characterized by the activation of intra-renal haemostatic and inflammatory processes. Platelets, which are present in high numbers in the circulation and can rapidly release a broad spectrum of bioactive mediators, are important acute modulators of inflammation and haemostasis, as they are the first cells to arrive at sites of acute injury, where they interact with endothelial cells and leukocytes...
May 14, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29752446/gwas-highlights-challenges-associated-with-identification-of-dkd-risk-variants
#6
Susan J Allison
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29730670/haemodialysis-membranes
#7
REVIEW
Claudio Ronco, William R Clark
Haemodialysis is an extracorporeal process in which the blood is cleansed via removal of uraemic retention products by a semipermeable membrane. Traditionally, dialysis membranes have been broadly classified on the basis of their composition (cellulosic or noncellulosic) and water permeability (low flux or high flux). However, advances in materials technology and polymer chemistry have led to the development of membranes with specific characteristics and refined properties that mandate a reconsideration of traditional membrane classification systems...
May 5, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29717191/cellular-recording-devices-imprint-the-history-of-the-cell
#8
Nicholas J Steers, Ali G Gharavi
No abstract text is available yet for this article.
May 1, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29717190/rethinking-progression-of-ckd-as-a-process-of-punctuated-equilibrium
#9
Richard J Johnson, Bernardo Rodriguez-Iturbe
No abstract text is available yet for this article.
May 1, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29717189/subclassification-of-diabetes-based-on-quantitative-traits
#10
Peter Rossing
No abstract text is available yet for this article.
May 1, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29700488/diagnosis-and-management-of-resistant-hypertension-state-of-the-art
#11
REVIEW
Fang-Fei Wei, Zhen-Yu Zhang, Qi-Fang Huang, Jan A Staessen
Resistant hypertension is defined as a lack of ambulatory blood pressure response to optimized medical treatment after exclusion of secondary hypertension in patients who are fully adherent to antihypertensive therapy. Patients with resistant hypertension are at high risk of complications, particularly cardiovascular events, and optimization of medical treatment remains the cornerstone of their management. Such optimization should be based on simple algorithms and include the use of aldosterone antagonists...
April 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29700487/is-ciliary-hedgehog-signalling-dispensable-in-the-kidneys
#12
Edgar A Otto
No abstract text is available yet for this article.
April 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29695753/whole-kidney-single-cell-transcriptomics-identifies-new-cell-types
#13
Jack M Heintze
No abstract text is available yet for this article.
June 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29695752/gatm-mutations-cause-mitochondrial-abnormalities-and-kidney-failure
#14
Ellen F Carney
No abstract text is available yet for this article.
April 25, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29691495/mechanisms-and-treatment-of-organ-failure-in-sepsis
#15
REVIEW
Christophe Lelubre, Jean-Louis Vincent
Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction. Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the management and treatment of patients and for the development of potential new therapies. In clinical practice, six major organ systems - the cardiovascular (including the microcirculation), respiratory, renal, neurological, haematological and hepatic systems - can be assessed and monitored, whereas others, such as the gut, are less accessible...
April 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29654298/abnormal-saline-and-the-history-of-intravenous-fluids
#16
John A Kellum
No abstract text is available yet for this article.
April 13, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29654297/ckd-in-diabetes-diabetic-kidney-disease-versus-nondiabetic-kidney-disease
#17
REVIEW
Hans-Joachim Anders, Tobias B Huber, Berend Isermann, Mario Schiffer
The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic kidney disease (DKD; also known as diabetic nephropathy). The limited success of much of this research might in part be due to the fact that not all patients diagnosed with DKD have renal dysfunction as a consequence of their diabetes mellitus. Patients who present with CKD and diabetes mellitus (type 1 or type 2) can have true DKD (wherein CKD is a direct consequence of their diabetes status), nondiabetic kidney disease (NDKD) coincident with diabetes mellitus, or a combination of both DKD and NDKD...
April 13, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29651098/implantable-cardioverter-defibrillators-in-chronic-kidney-disease
#18
Finnian R Mc Causland, Marc A Pfeffer
No abstract text is available yet for this article.
April 12, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29643464/osteopontin-drives-renal-metabolic-dysfunction-in-alport-syndrome
#19
Ellen F Carney
No abstract text is available yet for this article.
April 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29629715/genetics-an-integrated-genetic-analysis-of-disease
#20
David L Mattson
No abstract text is available yet for this article.
April 9, 2018: Nature Reviews. Nephrology
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