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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28781373/diabetes-mellitus-cardiovascular-and-renal-benefits-of-sglt2-inhibition-insights-from-canvas
#1
Volker Vallon, Scott C Thomson
No abstract text is available yet for this article.
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781372/uromodulin-from-physiology-to-rare-and-complex-kidney-disorders
#2
REVIEW
Olivier Devuyst, Eric Olinger, Luca Rampoldi
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect against urinary tract infection and kidney stones, and have roles in kidney injury and innate immunity. Interest in uromodulin was boosted by genetic studies that reported involvement of the UMOD gene, which encodes uromodulin, in a spectrum of rare and common kidney diseases...
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781371/t-helper-type-17-cells-in-immune-mediated-glomerular-disease
#3
REVIEW
Christian F Krebs, Tilman Schmidt, Jan-Hendrik Riedel, Ulf Panzer
CD4(+) T cells are important drivers of tissue damage in immune-mediated renal diseases, such as anti-glomerular basement membrane glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, and lupus nephritis. The discovery of a distinct, IL-17-producing CD4(+) T-cell lineage termed T helper type 17 (TH17) cells has markedly advanced current understanding of the pathogenic mechanisms of organ-specific immunity and the pathways that lead to target organ damage. TH17 cells are characterized by the expression of the transcription factor RORγt, the production of the pro-inflammatory cytokines IL-17A, IL-17F, IL-22, and high expression of the chemokine receptor C-C-motif chemokine receptor 6 (CCR6)...
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781370/podocyte-biology-proteolytic-processing-in-podocytes
#4
Grant Otto
No abstract text is available yet for this article.
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781369/polycystic-kidney-disease-fpc-in-arpkd
#5
Susan J Allison
No abstract text is available yet for this article.
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757638/glomerular-disease-functional-consequences-of-c5-nephritic-factors-in-c3-glomerulopathies
#6
Ellen F Carney
No abstract text is available yet for this article.
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757637/intravenous-hydroxocobalamin-and-crystal-nephropathy
#7
Matthieu Legrand, Vincent Mallet
No abstract text is available yet for this article.
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757636/supar-and-fsgs-is-the-jury-still-out
#8
Lorenzo Gallon, Susan E Quaggin
No abstract text is available yet for this article.
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757635/mechanisms-and-consequences-of-carbamoylation
#9
REVIEW
Sigurd Delanghe, Joris R Delanghe, Reinhart Speeckaert, Wim Van Biesen, Marijn M Speeckaert
Protein carbamoylation is a non-enzymatic post-translational modification that binds isocyanic acid, which can be derived from the dissociation of urea or from the myeloperoxidase-mediated catabolism of thiocyanate, to the free amino groups of a multitude of proteins. Although the term 'carbamoylation' is usually replaced by the term "carbamylation" in the literature, carbamylation refers to a different chemical reaction (the reversible interaction of CO2 with α and ε-amino groups of proteins). Depending on the altered molecule (for example, collagen, erythropoietin, haemoglobin, low-density lipoprotein or high-density lipoprotein), carbamoylation can have different pathophysiological effects...
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757634/experimental-concerns-regarding-supar-related-proteinuria
#10
Laurent Mesnard, Yosu Luque, Eric Rondeau
No abstract text is available yet for this article.
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28736435/extracellular-vesicles-in-renal-disease
#11
REVIEW
Diana Karpman, Anne-Lie Ståhl, Ida Arvidsson
Extracellular vesicles, such as exosomes and microvesicles, are host cell-derived packages of information that allow cell-cell communication and enable cells to rid themselves of unwanted substances. The release and uptake of extracellular vesicles has important physiological functions and may also contribute to the development and propagation of inflammatory, vascular, malignant, infectious and neurodegenerative diseases. This Review describes the different types of extracellular vesicles, how they are detected and the mechanisms by which they communicate with cells and transfer information...
July 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28736434/diabetic-nephropathy-restoring-podocyte-proteostasis-in-dn
#12
Ellen F Carney
No abstract text is available yet for this article.
July 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28736433/diabetes-mellitus-complex-interplay-between-metformin-aki-and-lactic-acidosis
#13
Connie M Rhee, Kamyar Kalantar-Zadeh
No abstract text is available yet for this article.
July 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28736432/polycystic-kidney-disease-dzip1l-defines-a-new-functional-zip-code-for-autosomal-recessive-pkd
#14
Erum A Hartung, Lisa M Guay-Woodford
No abstract text is available yet for this article.
July 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28713167/cell-biology-connexin-connections-in-gn
#15
Grant Otto
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28713166/infection-impeding-upec-gut-colonization
#16
Clemens Thoma
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669992/treatment-of-membranous-nephropathy-time-for-a-paradigm-shift
#17
REVIEW
Piero Ruggenenti, Fernando C Fervenza, Giuseppe Remuzzi
In patients with membranous nephropathy, alkylating agents (cyclophosphamide or chlorambucil) alone or in combination with steroids achieve remission of nephrotic syndrome more effectively than conservative treatment or steroids alone, but can cause myelotoxicity, infections, and cancer. Calcineurin inhibitors can improve proteinuria, but are nephrotoxic. Most patients relapse after treatment withdrawal and can become treatment dependent, which increases the risk of nephrotoxicity. The discovery of nephritogenic autoantibodies against podocyte M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain- containing protein 7A (THSD7A) antigens provides a clear pathophysiological rationale for interventions that specifically target B-cell lineages to prevent antibody production and subepithelial deposition...
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669991/polycystic-kidney-disease-smyd2-is-a-novel-epigenetic-regulator-of-cyst-growth
#18
Andrea Aguilar
No abstract text is available yet for this article.
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669990/chronic-kidney-disease-role-of-supar-in-apol1-associated-kidney-disease
#19
Ellen F Carney
No abstract text is available yet for this article.
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28691713/targeted-therapies-for-renal-cell-carcinoma
#20
REVIEW
Edwin M Posadas, Suwicha Limvorasak, Robert A Figlin
The management of patients with metastatic renal cell carcinoma (RCC) has changed dramatically over the past few years. Nephrectomy remains an important intervention for localized RCC but systemic therapy is the mainstay of treatment for patients who relapse after surgery or who have metastatic RCC. Before 2005, medical therapies for RCC were limited to cytokine therapies, which are very toxic and benefit only a small percentage of patients. In 2017, therapeutic agents now include kinase and immune checkpoint inhibitors...
August 2017: Nature Reviews. Nephrology
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