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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28090083/kidney-disease-and-obesity-epidemiology-mechanisms-and-treatment
#1
REVIEW
Niels Olsen Saraiva Câmara, Kunitoshi Iseki, Holly Kramer, Zhi-Hong Liu, Kumar Sharma
The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed...
January 16, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28090082/polycystic-kidney-disease-autophagy-boost-to-treat-adpkd
#2
Andrea Aguilar
No abstract text is available yet for this article.
January 16, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28090081/metabolic-reprogramming-and-tolerance-during-sepsis-induced-aki
#3
REVIEW
Hernando Gómez, John A Kellum, Claudio Ronco
The host defence against infection is an adaptive response in which several mechanisms are deployed to decrease the pathogen load, limit tissue injury and restore homeostasis. In the past few years new evidence has suggested that the ability of the immune system to limit the microbial burden - termed resistance - might not be the only defence mechanism. In fact, the capacity of the host to decrease its own susceptibility to inflammation- induced tissue damage - termed tolerance - might be as important as resistance in determining the outcome of the infection...
January 16, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029155/glomerular-disease-rituximab-therapy-for-iga-nephropathy
#4
Jürgen Floege
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029154/changes-in-the-worldwide-epidemiology-of-peritoneal-dialysis
#5
REVIEW
Philip Kam-Tao Li, Kai Ming Chow, Moniek W M Van de Luijtgaarden, David W Johnson, Kitty J Jager, Rajnish Mehrotra, Sarala Naicker, Roberto Pecoits-Filho, Xue Qing Yu, Norbert Lameire
As the global burden of chronic kidney disease continues to increase, so does the need for a cost-effective renal replacement therapy. In many countries, patient outcomes with peritoneal dialysis are comparable to or better than those with haemodialysis, and peritoneal dialysis is also more cost-effective. These benefits have not, however, always led to increased utilization of peritoneal dialysis. Use of this therapy is increasing in some countries, including China, the USA and Thailand, but has proportionally decreased in parts of Europe and in Japan...
December 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029153/cellular-senescence-in-renal-ageing-and-disease
#6
REVIEW
Ines Sturmlechner, Matej Durik, Cynthia J Sieben, Darren J Baker, Jan M van Deursen
The senescence programme is implicated in diverse biological processes, including embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo studies of senescence are in their infancy, evidence suggesting that senescent cells are a heterogeneous cell type is accumulating: senescence can be induced by different stressors, and senescent cells have varying degrees of genomic and epigenomic instability and different cell origins, contributing to their diversity. Two main classes of senescent cells have been identified: acute and chronic senescent cells...
December 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029152/hypertension-in-2016-blood-pressure-goals-variability-and-sglt2-blockade-in-ckd
#7
Debbie L Cohen, Raymond R Townsend
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27990017/glomerular-disease-role-of-tonsillar-b-cells-in-igan
#8
Ellen F Carney
No abstract text is available yet for this article.
December 19, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27990016/thrombotic-microangiopathies-vegf-complement-interactions
#9
Susan J Allison
No abstract text is available yet for this article.
December 19, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27990015/the-renal-fanconi-syndrome-in-cystinosis-pathogenic-insights-and-therapeutic-perspectives
#10
REVIEW
Stephanie Cherqui, Pierre J Courtoy
Cystinosis is an autosomal recessive metabolic disease that belongs to the family of lysosomal storage disorders. It is caused by a defect in the lysosomal cystine transporter, cystinosin, which results in an accumulation of cystine in all organs. Despite the ubiquitous expression of cystinosin, a renal Fanconi syndrome is often the first manifestation of cystinosis, usually presenting within the first year of life and characterized by the early and severe dysfunction of proximal tubule cells, highlighting the unique vulnerability of this cell type...
December 19, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27941934/the-global-burden-of-chronic-kidney-disease-estimates-variability-and-pitfalls
#11
REVIEW
Richard J Glassock, David G Warnock, Pierre Delanaye
Chronic kidney disease (CKD) is currently defined by abnormalities of kidney structure or function assessed using a matrix of variables - including glomerular filtration rate (GFR), thresholds of albuminuria and duration of injury - and is considered by many to be a common disorder globally. However, estimates of CKD prevalence vary widely, both within and between countries. The reasons for these variations are manifold, and include true regional differences in CKD prevalence, vagaries of using estimated GFR (eGFR) for identifying CKD, issues relating to the use of set GFR thresholds to define CKD in elderly populations, and concerns regarding the use of one-off testing for assessment of eGFR or albuminuria to define the prevalence of CKD in large-scale epidemiological studies...
December 12, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27916975/epidemiology-paediatric-acute-kidney-injury
#12
Ellen F Carney
No abstract text is available yet for this article.
December 5, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27916974/autoimmune-disease-egress-of-intestinal-th17-cells-in-autoimmune-renal-disease
#13
Susan J Allison
No abstract text is available yet for this article.
December 5, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27916973/fibrosis-pericyte-myd88-and-irak4-signalling-in-fibrosis
#14
Susan J Allison
No abstract text is available yet for this article.
December 5, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27916972/chronic-kidney-disease-mechanisms-of-apol1-associated-renal-disease
#15
Ellen F Carney
No abstract text is available yet for this article.
December 5, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840421/loaded-locked-drawn-ksort-validated-for-patient-samples
#16
Silke Roedder, Nathan Salomonis
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840419/caveat-emptor-the-devil-is-still-in-the-detail
#17
Michael Abecassis, Bruce Kaplan
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27941935/renal-metabolic-and-cardiovascular-considerations-of-sglt2-inhibition
#18
REVIEW
Ralph A DeFronzo, Luke Norton, Muhammad Abdul-Ghani
The kidney has a pivotal role in maintaining glucose homeostasis by using glucose as a metabolic fuel, by producing glucose through gluconeogenesis, and by reabsorbing all filtered glucose through the sodium-glucose cotransporters SGLT1 and SGLT2 located in the proximal tubule. In patients with diabetes, the maximum glucose reabsorptive capacity (TmG) of the kidney, as well as the threshold for glucose spillage into the urine, are elevated, contributing to the pathogenesis of hyperglycaemia. By reducing the TmG and, more importantly, the threshold of glucosuria, SGLT2 inhibitors enhance glucose excretion, leading to a reduction in fasting and postprandial plasma glucose levels and improvements in both insulin secretion and insulin sensitivity...
January 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27941933/transplantation-efficacy-of-rapid-steroid-withdrawal-after-induction-therapy
#19
Andrea Aguilar
No abstract text is available yet for this article.
January 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27924083/haemodialysis-intradialytic-meals-addressing-a-neglected-problem
#20
Francesco Locatelli, Lucia Del Vecchio
No abstract text is available yet for this article.
January 2017: Nature Reviews. Nephrology
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