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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28435157/the-systemic-nature-of-ckd
#1
REVIEW
Carmine Zoccali, Raymond Vanholder, Ziad A Massy, Alberto Ortiz, Pantelis Sarafidis, Friedo W Dekker, Danilo Fliser, Denis Fouque, Gunnar H Heine, Kitty J Jager, Mehmet Kanbay, Francesca Mallamaci, Gianfranco Parati, Patrick Rossignol, Andrzej Wiecek, Gerard London
The accurate definition and staging of chronic kidney disease (CKD) is one of the major achievements of modern nephrology. Intensive research is now being undertaken to unravel the risk factors and pathophysiologic underpinnings of this disease. In particular, the relationships between the kidney and other organs have been comprehensively investigated in experimental and clinical studies in the last two decades. Owing to technological and analytical limitations, these links have been studied with a reductionist approach focusing on two organs at a time, such as the heart and the kidney or the bone and the kidney...
April 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28435156/polycystic-kidney-disease-pmm2-mutation-causes-pkd-and-hyperinsulinism
#2
Ellen F Carney
No abstract text is available yet for this article.
April 24, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28420887/kidney-cancer-targeting-metabolism-in-rcc
#3
Susan J Allison
No abstract text is available yet for this article.
April 19, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28420886/hypertension-hypertension-in-pregnancy-a-risk-factor-for-the-whole-family
#4
Grace Z Yu, Paul Leeson
No abstract text is available yet for this article.
April 19, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28392564/the-immunology-of-atherosclerosis
#5
REVIEW
Anton Gisterå, Göran K Hansson
Cardiovascular disease is the leading cause of death worldwide, both in the general population and among patients with chronic kidney disease (CKD). In most cases, the underlying cause of the cardiovascular event is atherosclerosis - a chronic inflammatory disease. CKD accelerates atherosclerosis via augmentation of inflammation, perturbation of lipid metabolism, and other mechanisms. In the artery wall, subendothelial retention of plasma lipoproteins triggers monocyte-derived macrophages and T helper type 1 (TH1) cells to form atherosclerotic plaques...
April 10, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28392563/ageing-targeting-senescence-associated-tissue-damage
#6
Susan J Allison
No abstract text is available yet for this article.
April 10, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28392562/hypertension-role-of-%C3%AE-%C3%AE-t-cells-in-the-development-of-hypertension
#7
Ellen F Carney
No abstract text is available yet for this article.
April 10, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28392561/diabetes-renal-responses-to-sglt2-blockade
#8
Andrea Aguilar
No abstract text is available yet for this article.
April 10, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28366948/renal-fibrosis-pericytes-activate-complement-in-fibrosis
#9
Shimona Starling
No abstract text is available yet for this article.
April 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28366947/hypertension-quarter-dose-quadpill-combinations-a-new-therapeutic-approach
#10
Guido Grassi, Giuseppe Mancia
No abstract text is available yet for this article.
April 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28366945/transplantation-pro-tolerogenic-properties-of-erythropoietin
#11
Ellen F Carney
No abstract text is available yet for this article.
April 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28366942/renal-and-cardiac-assessment-of-living-kidney-donor-candidates
#12
REVIEW
Ngan N Lam, Krista L Lentine, Amit X Garg
Living kidney donation provides the best therapeutic outcomes for eligible patients with end-stage renal disease. To ensure suitability for living kidney donation, donor candidates undergo a thorough medical, surgical, and psychosocial evaluation by a multidisciplinary transplant assessment team. Numerous guidelines are available to assist clinicians in the process of donor evaluation and selection. These guidelines outline the minimum recommended requirements for donor screening and additional tests that are indicated when abnormalities arise; however, evidence suggests that some of these additional tests might not be required in certain donor candidates...
April 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28344330/acute-kidney-injury-intravenous-hydration-for-the-prevention-of-ciaki
#13
Carlo Briguori, Giuseppe Signoriello
No abstract text is available yet for this article.
March 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28344329/glomerular-disease-mtor-in-fsgs
#14
Susan J Allison
No abstract text is available yet for this article.
March 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28344328/renal-physiology-hco3-reclamation-in-the-renal-proximal-tubule
#15
Ellen F Carney
No abstract text is available yet for this article.
March 27, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28316335/complement-in-anca-associated-vasculitis-mechanisms-and-implications-for-management
#16
REVIEW
Min Chen, David R W Jayne, Ming-Hui Zhao
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of potentially life-threatening autoimmune diseases. The main histological feature in the kidneys of patients with AAV is pauci-immune necrotizing crescentic glomerulonephritis with little immunoglobulin and complement deposition in the glomerular capillary walls. The complement system was not, therefore, initially thought to be associated with the development of AAV. Accumulating evidence from animal models and clinical observations indicate, however, that activation of the complement system - and the alternative pathway in particular - is crucial for the development of AAV, and that the complement activation product C5a has a central role...
March 20, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28316334/chronic-kidney-disease-uraemic-toxin-induced-platelet-hyperactivity
#17
Susan J Allison
No abstract text is available yet for this article.
March 20, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28287110/t-cells-and-autoimmune-kidney-disease
#18
REVIEW
Abel Suárez-Fueyo, Sean J Bradley, David Klatzmann, George C Tsokos
Glomerulonephritis is traditionally considered to result from the invasion of the kidney by autoantibodies and immune complexes from the circulation or following their formation in situ, and by cells of the innate and the adaptive immune system. The inflammatory response leads to the proliferation and dysfunction of cells of the glomerulus, and invasion of the interstitial space with immune cells, resulting in tubular cell malfunction and fibrosis. T cells are critical drivers of autoimmunity and related organ damage, by supporting B-cell differentiation and antibody production or by directly promoting inflammation and cytotoxicity against kidney resident cells...
March 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28287109/lupus-nephritis-t-bet-b-cells-mediate-renal-injury-in-lupus
#19
Andrea Aguilar
No abstract text is available yet for this article.
March 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28262772/transplantation-desensitization-and-survival-in-kidney-transplant-recipients
#20
Caner Süsal, Gerhard Opelz
No abstract text is available yet for this article.
March 6, 2017: Nature Reviews. Nephrology
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