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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28919632/cd36-in-chronic-kidney-disease-novel-insights-and-therapeutic-opportunities
#1
REVIEW
Xiaochun Yang, Daryl M Okamura, Xifeng Lu, Yaxi Chen, John Moorhead, Zac Varghese, Xiong Z Ruan
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids, advanced oxidation protein products, thrombospondin and advanced glycation end products, and has roles in lipid accumulation, inflammatory signalling, energy reprogramming, apoptosis and kidney fibrosis. Renal CD36 is mainly expressed in tubular epithelial cells, podocytes and mesangial cells, and is markedly upregulated in the setting of chronic kidney disease (CKD)...
September 18, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28890539/transplantation-ides-to-desensitize-organ-allograft-recipients
#2
Georg A Böhmig, Lionel Rostaing
No abstract text is available yet for this article.
September 11, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28890538/kidney-cancer-targeting-wilms-tumour
#3
Grant Otto
No abstract text is available yet for this article.
September 11, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28890537/nephrotic-syndrome-novel-monogenic-causes-of-galloway-mowat-syndrome
#4
Ellen F Carney
No abstract text is available yet for this article.
September 11, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28869252/chronic-kidney-disease-pld4-regulates-kidney-fibrosis
#5
Ellen F Carney
No abstract text is available yet for this article.
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28869251/cardiac-surgery-associated-acute-kidney-injury-risk-factors-pathophysiology-and-treatment
#6
REVIEW
Ying Wang, Rinaldo Bellomo
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the most common clinically important complication in adult patients undergoing open heart surgery, and is associated with increased mortality and morbidity. In patients in intensive care units, CSA-AKI is the second most common type of AKI after septic AKI. In this Review, we explore the definition of CSA-AKI, discuss its epidemiology and identify its risk factors. We discuss current theories of the pathophysiology of CSA-AKI and describe its clinical course...
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28869250/hypertension-a-new-genetic-clue-to-unravel-the-origins-of-pre-eclampsia
#7
Eric M George, Joey P Granger
No abstract text is available yet for this article.
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28869249/glp-1-and-the-kidney-from-physiology-to-pharmacology-and-outcomes-in-diabetes
#8
REVIEW
Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Michaël J B van Baar, Mark H H Kramer, Ewout J Hoorn, Jaap A Joles, Daniël H van Raalte
The gastrointestinal tract - the largest endocrine network in human physiology - orchestrates signals from the external environment to maintain neural and hormonal control of homeostasis. Advances in understanding entero-endocrine cell biology in health and disease have important translational relevance. The gut-derived incretin hormone glucagon-like peptide 1 (GLP-1) is secreted upon meal ingestion and controls glucose metabolism by modulating pancreatic islet cell function, food intake and gastrointestinal motility, amongst other effects...
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28869248/pre-eclampsia-screening-and-aspirin-therapy-for-prevention-of-pre-eclampsia
#9
James M Roberts, Katherine P Himes
No abstract text is available yet for this article.
September 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28852210/immunology-the-renal-sodium-gradient-in-antimicrobial-defence
#10
Susan J Allison
No abstract text is available yet for this article.
August 30, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28824173/renal-physiology-the-sexually-dimorphic-kidney
#11
Shimona Starling
No abstract text is available yet for this article.
August 21, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28824172/chronic-kidney-disease-kdigo-ckd-mbd-guideline-update-evolution-in-the-face-of-uncertainty
#12
Wei Chen, David A Bushinsky
No abstract text is available yet for this article.
August 21, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28804120/mitochondrial-energetics-in-the-kidney
#13
REVIEW
Pallavi Bhargava, Rick G Schnellmann
The kidney requires a large number of mitochondria to remove waste from the blood and regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these important functions and can adapt to different metabolic conditions through a number of signalling pathways (for example, mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways) that activate the transcriptional co-activator peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α), and by balancing mitochondrial dynamics and energetics to maintain mitochondrial homeostasis...
August 14, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781371/t-helper-type-17-cells-in-immune-mediated-glomerular-disease
#14
REVIEW
Christian F Krebs, Tilman Schmidt, Jan-Hendrik Riedel, Ulf Panzer
CD4(+) T cells are important drivers of tissue damage in immune-mediated renal diseases, such as anti-glomerular basement membrane glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, and lupus nephritis. The discovery of a distinct, IL-17-producing CD4(+) T-cell lineage termed T helper type 17 (TH17) cells has markedly advanced current understanding of the pathogenic mechanisms of organ-specific immunity and the pathways that lead to target organ damage. TH17 cells are characterized by the expression of the transcription factor RORγt, the production of the pro-inflammatory cytokines IL-17A, IL-17F, IL-22, and high expression of the chemokine receptor C-C-motif chemokine receptor 6 (CCR6)...
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781370/podocyte-biology-proteolytic-processing-in-podocytes
#15
Grant Otto
No abstract text is available yet for this article.
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781369/polycystic-kidney-disease-fpc-in-arpkd
#16
Susan J Allison
No abstract text is available yet for this article.
August 7, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757638/glomerular-disease-functional-consequences-of-c5-nephritic-factors-in-c3-glomerulopathies
#17
Ellen F Carney
No abstract text is available yet for this article.
July 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781373/diabetes-mellitus-cardiovascular-and-renal-benefits-of-sglt2-inhibition-insights-from-canvas
#18
Volker Vallon, Scott C Thomson
No abstract text is available yet for this article.
September 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28781372/uromodulin-from-physiology-to-rare-and-complex-kidney-disorders
#19
REVIEW
Olivier Devuyst, Eric Olinger, Luca Rampoldi
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect against urinary tract infection and kidney stones, and have roles in kidney injury and innate immunity. Interest in uromodulin was boosted by genetic studies that reported involvement of the UMOD gene, which encodes uromodulin, in a spectrum of rare and common kidney diseases...
September 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28757637/intravenous-hydroxocobalamin-and-crystal-nephropathy
#20
Matthieu Legrand, Vincent Mallet
No abstract text is available yet for this article.
September 2017: Nature Reviews. Nephrology
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