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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/29995834/hedgehog-tgf%C3%AE-signalling-controls-nephrogenesis
#1
Grant Otto
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29995833/pivotal-role-of-camk4-in-podocyte-injury
#2
Ellen F Carney
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29985463/hla-in-transplantation
#3
REVIEW
Robert A Montgomery, Vasishta S Tatapudi, Mary S Leffell, Andrea A Zachary
The human major histocompatibility complex is a family of genes that encodes HLAs, which have a crucial role in defence against foreign pathogens and immune surveillance of tumours. In the context of transplantation, HLA molecules are polymorphic antigens that comprise an immunodominant alloreactive trigger for the immune response, resulting in rejection. Remarkable advances in knowledge and technology in the field of immunogenetics have considerably enhanced the safety of transplantation. However, access to transplantation among individuals who have become sensitized as a result of previous exposure to alloantigens is reduced proportional to the breadth of their sensitization...
July 9, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29980772/renal-denervation-one-step-backwards-three-steps-forward
#4
Markus P Schlaich, George L Bakris
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29973730/the-role-of-nephrectomy-in-metastatic-renal-cell-carcinoma
#5
Viktor Grünwald, Axel Bex
No abstract text is available yet for this article.
July 4, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29959373/the-role-of-b7-1-in-proteinuria-of-glomerular-origin
#6
REVIEW
Rubina Novelli, Ariela Benigni, Giuseppe Remuzzi
The damage and loss of podocytes is a primary hallmark of nephrotic syndrome. In the pursuit of targetable molecules that are involved in podocyte pathophysiology, some studies have identified B7-1 (also known as CD80) as a potential biomarker. Furthermore, B7-1 blockade has been proposed as a podocyte-specific treatment for patients with nephrotic syndrome who have limited therapeutic options, such as those with focal segmental glomerulosclerosis, minimal change disease, diabetic nephropathy and lupus nephritis...
June 29, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29955104/targeting-arnt-to-attenuate-renal-fibrosis
#7
Susan J Allison
No abstract text is available yet for this article.
June 28, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29942044/pericytes-in-the-renal-vasculature-roles-in-health-and-disease
#8
REVIEW
Isaac Shaw, Sebastien Rider, John Mullins, Jeremy Hughes, Bruno Péault
In the dense circulatory system of the kidney, as in all vascularized tissues, pericytes enwrap capillaries and microvessels to regulate angiogenesis, stabilize microvascular networks and control blood flow by vasoconstriction. Specialized renal pericytes known as mesangial cells provide physical support to glomerular capillaries, whereas a subset of juxtaglomerular arteriolar pericytes control the local blood pressure in the glomerulus via contraction and influence systemic blood pressure by secreting renin...
June 25, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29921980/immune-networks-in-ci-aki
#9
Susan J Allison
No abstract text is available yet for this article.
June 19, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29899563/preserving-kidney-health-during-intensive-blood-pressure-control
#10
Maria Luisa S Sequeira-Lopez, R Ariel Gomez
No abstract text is available yet for this article.
June 13, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29895977/immunoregulatory-mechanisms-of-mesenchymal-stem-and-stromal-cells-in-inflammatory-diseases
#11
REVIEW
Yufang Shi, Yu Wang, Qing Li, Keli Liu, Jianquan Hou, Changshun Shao, Ying Wang
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have attracted much attention for their ability to regulate inflammatory processes. Their therapeutic potential is currently being investigated in various degenerative and inflammatory disorders such as Crohn's disease, graft-versus-host disease, diabetic nephropathy and organ fibrosis. The mechanisms by which MSCs exert their therapeutic effects are multifaceted, but in general, these cells are thought to enable damaged tissues to form a balanced inflammatory and regenerative microenvironment in the presence of vigorous inflammation...
June 12, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29875482/regulation-of-nephrogenesis
#12
Ellen Carney
No abstract text is available yet for this article.
June 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29875481/adverse-effects-of-sglt2-inhibitors-on-bone-health
#13
Jenny E Blau, Simeon I Taylor
No abstract text is available yet for this article.
June 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29875480/the-origin-evolution-and-route-to-metastasis-of-clear-cell-rcc
#14
Christopher J Ricketts, W Marston Linehan
No abstract text is available yet for this article.
June 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29855604/rho-like-gtpases-in-nephrotic-syndrome
#15
Grant Otto
No abstract text is available yet for this article.
May 31, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29802401/ahr-in-sle
#16
Joanna Collison
No abstract text is available yet for this article.
May 25, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29802400/cancer-in-kidney-transplant-recipients
#17
REVIEW
Eric Au, Germaine Wong, Jeremy R Chapman
Cancer is the second most common cause of mortality and morbidity in kidney transplant recipients after cardiovascular disease. Kidney transplant recipients have at least a twofold higher risk of developing or dying from cancer than the general population. The increased risk of de novo and recurrent cancer in transplant recipients is multifactorial and attributed to oncogenic viruses, immunosuppression and altered T cell immunity. Transplant candidates and potential donors should be screened for cancer as part of the assessment process...
May 25, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29799011/il-1%C3%AE-switches-on-kidney-fibrosis
#18
Grant Otto
No abstract text is available yet for this article.
May 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29799010/altered-ammonia-metabolism-in-ccrcc
#19
Ellen F Carney
No abstract text is available yet for this article.
May 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29789704/single-cell-rna-sequencing-for-the-study-of-development-physiology-and-disease
#20
REVIEW
S Steven Potter
An ongoing technological revolution is continually improving our ability to carry out very high-resolution studies of gene expression patterns. Current technology enables the global gene expression profiles of single cells to be defined, facilitating dissection of heterogeneity in cell populations that was previously hidden. In contrast to gene expression studies that use bulk RNA samples and provide only a virtual average of the diverse constituent cells, single-cell studies enable the molecular distinction of all cell types within a complex population mix, such as a tumour or developing organ...
May 22, 2018: Nature Reviews. Nephrology
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