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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/30367174/the-multifaceted-role-of-complement-in-kidney-transplantation
#1
REVIEW
Ali-Reza Biglarnia, Markus Huber-Lang, Camilla Mohlin, Kristina N Ekdahl, Bo Nilsson
Increasing evidence indicates an integral role for the complement system in the deleterious inflammatory reactions that occur during critical phases of the transplantation process, such as brain or cardiac death of the donor, surgical trauma, organ preservation and ischaemia-reperfusion injury, as well as in humoral and cellular immune responses to the allograft. Ischaemia is the most common cause of complement activation in kidney transplantation and in combination with reperfusion is a major cause of inflammation and graft damage...
October 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30367173/endocytosis-in-the-proximal-tubule
#2
Ellen F Carney
No abstract text is available yet for this article.
October 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30361677/lipid-management-in-patients-with-chronic-kidney-disease
#3
REVIEW
Charles J Ferro, Patrick B Mark, Mehmet Kanbay, Pantelis Sarafidis, Gunnar H Heine, Patrick Rossignol, Ziad A Massy, Francesca Mallamaci, Jose M Valdivielso, Jolanta Malyszko, Marianne C Verhaar, Robert Ekart, Raymond Vanholder, Gerard London, Alberto Ortiz, Carmine Zoccali
An increased risk of cardiovascular disease, independent of conventional risk factors, is present even at minor levels of renal impairment and is highest in patients with end-stage renal disease (ESRD) requiring dialysis. Renal dysfunction changes the level, composition and quality of blood lipids in favour of a more atherogenic profile. Patients with advanced chronic kidney disease (CKD) or ESRD have a characteristic lipid pattern of hypertriglyceridaemia and low HDL cholesterol levels but normal LDL cholesterol levels...
October 25, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30348952/albuminuria-as-a-cause-of-hypertension
#4
Ron T Gansevoort, Harold Snieder
No abstract text is available yet for this article.
October 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30341438/arginine-auxotrophy-in-pkd
#5
Monica Wang
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30337707/central-nervous-system-neuroplasticity-and-the-sensitization-of-hypertension
#6
REVIEW
Alan Kim Johnson, Baojian Xue
The causes of essential hypertension remain an enigma. Interactions between genetic and external factors are generally recognized to act as aetiological mechanisms that trigger the pathogenesis of high blood pressure. However, the questions of which genes and factors are involved, and when and where such interactions occur, remain unresolved. Emerging evidence indicates that the hypertensive response to pressor stimuli, like many other physiological and behavioural adaptations, can become sensitized to particular stimuli...
October 18, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30327552/a-link-between-mitochondrial-dysfunction-and-innate-immune-activation-in-fsgs
#7
Ellen F Carney
No abstract text is available yet for this article.
October 16, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30297965/blocking-cd122-might-improve-outcomes
#8
Rebecca Kelsey
No abstract text is available yet for this article.
October 8, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30283063/3d-printing-aids-transplantation-planning
#9
Monica Wang
No abstract text is available yet for this article.
October 3, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30279535/genome-wide-polygenic-risk-predictors-for-kidney-disease
#10
Lili Liu, Krzysztof Kiryluk
No abstract text is available yet for this article.
October 2, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30279534/autosomal-dominant-pkd-gets-an-atomic-map
#11
Paul A Welling
No abstract text is available yet for this article.
October 2, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30262845/newly-identified-parvovirus-causes-kidney-failure-in-mice
#12
Monica Wang
No abstract text is available yet for this article.
September 27, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30250309/npc-mutations-cause-srns
#13
Rebecca Kelsey
No abstract text is available yet for this article.
September 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30171208/augmenting-nad-may-combat-kidney-stress
#14
Ellen F Carney
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30166605/glp1-fragments-protect-the-kidney
#15
Monica Wang
No abstract text is available yet for this article.
August 30, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30143788/the-odyssey-of-risk-stratification-in-acute-kidney-injury
#16
Faeq Husain-Syed, Claudio Ronco
No abstract text is available yet for this article.
August 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30143787/circadian-rhythms-and-the-kidney
#17
REVIEW
Dmitri Firsov, Olivier Bonny
Numerous physiological functions exhibit substantial circadian oscillations. In the kidneys, renal plasma flow, the glomerular filtration rate and tubular reabsorption and/or secretion processes have been shown to peak during the active phase and decline during the inactive phase. These functional rhythms are driven, at least in part, by a self-sustaining cellular mechanism termed the circadian clock. The circadian clock controls different cellular functions, including transcription, translation and protein post-translational modifications (such as phosphorylation, acetylation and ubiquitylation) and degradation...
August 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30135570/global-epidemiology-and-outcomes-of-acute-kidney-injury
#18
REVIEW
Eric A J Hoste, John A Kellum, Nicholas M Selby, Alexander Zarbock, Paul M Palevsky, Sean M Bagshaw, Stuart L Goldstein, Jorge Cerdá, Lakhmir S Chawla
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various aetiologies and pathophysiological processes leading to decreased kidney function. In addition to retention of waste products, impaired electrolyte homeostasis and altered drug concentrations, AKI induces a generalized inflammatory response that affects distant organs. Full recovery of kidney function is uncommon, which leaves these patients at risk of long-term morbidity and death. Estimates of AKI prevalence range from <1% to 66%...
August 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30287921/author-correction-intravenous-fluid-therapy-in-critically-ill-adults
#19
Simon Finfer, John Myburgh, Rinaldo Bellomo
Corrections: Fig. 1: 'MAP' inserted before '60-65 mmHg; Fig. 3: 'Echocardiography' amended to 'Electrocardiographic'. Fig. 4b additions: two cell nuclei; text labels 'Large pore transporting plasma proteins', 'Small pore network', 'Intercellular cleft'; 'Intact' and 'Damaged'; legend updated.
November 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30237443/ask1-inhibition-shows-potential-in-dkd
#20
Rebecca Kelsey
No abstract text is available yet for this article.
November 2018: Nature Reviews. Nephrology
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