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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/27890924/cellular-plasticity-in-kidney-injury-and-repair
#1
REVIEW
Monica Chang-Panesso, Benjamin D Humphreys
Terminally differentiated cells can be reprogrammed to pluripotency or directly to another differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to in vitro manipulations but rather represents an important aspect of the regenerative response to injury in organs. Differentiated adult cells retain the capacity to dedifferentiate, adopting a progenitor-like phenotype after injury or, alternatively, to transdifferentiate, directly converting to a different mature cell type...
November 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27890923/the-epigenetic-landscape-of-renal-cancer
#2
REVIEW
Mark R Morris, Farida Latif
The majority of kidney cancers are associated with mutations in the von Hippel-Lindau gene and a small proportion are associated with infrequent mutations in other well characterized tumour-suppressor genes. In the past 15 years, efforts to uncover other key genes involved in renal cancer have identified many genes that are dysregulated or silenced via epigenetic mechanisms, mainly through methylation of promoter CpG islands or dysregulation of specific microRNAs. In addition, the advent of next-generation sequencing has led to the identification of several novel genes that are mutated in renal cancer, such as PBRM1, BAP1 and SETD2, which are all involved in histone modification and nucleosome and chromatin remodelling...
November 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27867191/sepsis-preventing-organ-failure-in-sepsis-the-search-continues
#3
Thomas J Graetz, Richard S Hotchkiss
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27867190/hypertension-microbiota-under-pressure
#4
Andrea Aguilar
No abstract text is available yet for this article.
November 21, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27867189/the-role-of-phosphate-in-kidney-disease
#5
REVIEW
Marc G Vervloet, Siren Sezer, Ziad A Massy, Lina Johansson, Mario Cozzolino, Denis Fouque
The importance of phosphate homeostasis in chronic kidney disease (CKD) has been recognized for decades, but novel insights - which are frequently relevant to everyday clinical practice - continue to emerge. Epidemiological data consistently indicate an association between hyperphosphataemia and poor clinical outcomes. Moreover, compelling evidence suggests direct toxicity of increased phosphate concentrations. Importantly, serum phosphate concentration has a circadian rhythm that must be considered when interpreting patient phosphate levels...
November 21, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840421/loaded-locked-drawn-ksort-validated-for-patient-samples
#6
Silke Roedder, Nathan Salomonis
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840420/lupus-nephritis-b-cell-er%C3%AE-signalling-promotes-lupus-development
#7
Ellen F Carney
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840419/caveat-emptor-the-devil-is-still-in-the-detail
#8
Michael Abecassis, Bruce Kaplan
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840418/developmental-biology-transcriptional-reprogramming-of-kidney-tubules
#9
Susan J Allison
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27840417/hypertension-mechanosensation-by-piezo1-in-blood-pressure-control
#10
Susan J Allison
No abstract text is available yet for this article.
November 14, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27818506/the-contribution-of-branching-morphogenesis-to-kidney-development-and-disease
#11
REVIEW
Kieran M Short, Ian M Smyth
The mammalian kidney develops from a simple epithelial bud to an arborized network of tubules, which are fated to form the ureter, renal pelvis and collecting ducts. This process of ductal elaboration is achieved through an ancient developmental mechanism known as branching morphogenesis that is widely employed in glandular organs, the vasculature and lungs. It breaks up large solid tissues facilitating secretion, excretion and gas exchange, depending on the tissue. In the kidney, growth of the ureteric bud is driven by interactions between progenitor cells in the tips of the epithelial tree and their mesenchymal 'caps'...
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27818505/acute-kidney-injury-loss-of-pkc-%C3%A9-protects-against-iri
#12
Andrea Aguilar
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27795549/nanomedicines-for-renal-disease-current-status-and-future-applications
#13
REVIEW
Nazila Kamaly, John C He, Dennis A Ausiello, Omid C Farokhzad
Treatment and management of kidney disease currently presents an enormous global burden, and the application of nanotechnology principles to renal disease therapy, although still at an early stage, has profound transformative potential. The increasing translation of nanomedicines to the clinic, alongside research efforts in tissue regeneration and organ-on-a-chip investigations, are likely to provide novel solutions to treat kidney diseases. Our understanding of renal anatomy and of how the biological and physico-chemical properties of nanomedicines (the combination of a nanocarrier and a drug) influence their interactions with renal tissues has improved dramatically...
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27795548/stones-utilizing-bacterial-factors-for-kidney-stone-prevention
#14
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748394/sepsis-vasopressin-a-first-line-agent-for-septic-shock
#15
Jean-Louis Vincent, Emiel H Post
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748393/genetics-genetic-factors-in-the-regulation-of-blood-pressure
#16
Nicholette D Palmer, Barry I Freedman
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748392/minimal-change-disease-and-idiopathic-fsgs-manifestations-of-the-same-disease
#17
REVIEW
Rutger J Maas, Jeroen K Deegens, Bart Smeets, Marcus J Moeller, Jack F Wetzels
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and idiopathic FSGS are often considered to represent separate entities based on differences in their presenting characteristics, histology and outcomes, little evidence exists for this separation. We propose that MCD and idiopathic FSGS are different manifestations of the same progressive disease. The gradual development of FSGS in patients with non-remitting or relapsing INS has been well documented...
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748391/thrombosis-new-mechanism-of-thrombus-formation-in-ckd
#18
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748390/kidney-cancer-imprint-no-survival-benefit-of-ima901-in-rcc
#19
Ellen F Carney
No abstract text is available yet for this article.
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27748389/the-impact-of-insulin-resistance-on-the-kidney-and-vasculature
#20
REVIEW
Ferruh Artunc, Erwin Schleicher, Cora Weigert, Andreas Fritsche, Norbert Stefan, Hans-Ulrich Häring
Insulin resistance is a systemic disorder that affects many organs and insulin-regulated pathways. The disorder is characterized by a reduced action of insulin despite increased insulin concentrations (hyperinsulinaemia). The effects of insulin on the kidney and vasculature differ in part from the effects on classical insulin target organs. Insulin causes vasodilation by enhancing endothelial nitric oxide production through activation of the phosphatidylinositol 3-kinase pathway. In insulin-resistant states, this pathway is impaired and the mitogen-activated protein kinase pathway stimulates vasoconstriction...
December 2016: Nature Reviews. Nephrology
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