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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28190878/kidney-cancer-ccr4-a-new-target-for-rcc
#1
Susan J Allison
No abstract text is available yet for this article.
February 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28190877/hyponatraemia-unfolding-osmotic-demyelination
#2
Andrea Aguilar
No abstract text is available yet for this article.
February 13, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163308/genetics-genetic-and-functional-studies-reveal-genetic-drivers-of-renal-disease-in-digeorge-syndrome
#3
Susan J Allison
No abstract text is available yet for this article.
February 6, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163307/role-of-nad-and-mitochondrial-sirtuins-in-cardiac-and-renal-diseases
#4
REVIEW
Kathleen A Hershberger, Angelical S Martin, Matthew D Hirschey
The coenzyme nicotinamide adenine dinucleotide (NAD(+)) has key roles in the regulation of redox status and energy metabolism. NAD(+) depletion is emerging as a major contributor to the pathogenesis of cardiac and renal diseases and NAD(+) repletion strategies have shown therapeutic potential as a means to restore healthy metabolism and physiological function. The pleotropic roles of NAD(+) enable several possible avenues by which repletion of this coenzyme could have therapeutic efficacy. In particular, NAD(+) functions as a co-substrate in deacylation reactions carried out by the sirtuin family of enzymes...
February 6, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163306/heparanase-roles-in-cell-survival-extracellular-matrix-remodelling-and-the-development-of-kidney-disease
#5
REVIEW
Ton J Rabelink, Bernard M van den Berg, Marjolein Garsen, Ganqi Wang, Michael Elkin, Johan van der Vlag
Heparanase has regulatory roles in various processes, including cell communication, gene transcription and autophagy. In addition, it is the only known mammalian endoglycosidase that is capable of degrading heparan sulfate (HS). HS chains are important constituents and organizers of the extracellular matrix (ECM), and have a key role in maintaining the integrity and function of the glomerular filtration barrier. In addition, HS chains regulate the activity of numerous bioactive molecules, such as cytokines and growth factors, at the cell surface and in the ECM...
February 6, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163305/hypertension-role-of-arhgap42-in-hypertension
#6
Ellen F Carney
No abstract text is available yet for this article.
February 6, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28138129/polycystic-kidney-disease-pc2-function-insights-from-the-cold
#7
Andrea Aguilar
No abstract text is available yet for this article.
January 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28138127/sepsis-net-induced-coagulation-induces-organ-damage-in-sepsis
#8
Susan J Allison
No abstract text is available yet for this article.
January 31, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28111456/thrombotic-microangiopathies-complement-factor-h-beyond-ahus
#9
Andrea Aguilar
No abstract text is available yet for this article.
January 23, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28111455/glomerular-disease-chemotherapy-for-monoclonal-gammopathy-associated-c3g
#10
Susan J Allison
No abstract text is available yet for this article.
January 23, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28090082/polycystic-kidney-disease-autophagy-boost-to-treat-adpkd
#11
Andrea Aguilar
No abstract text is available yet for this article.
January 16, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029155/glomerular-disease-rituximab-therapy-for-iga-nephropathy
#12
Jürgen Floege
No abstract text is available yet for this article.
December 28, 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163310/acute-kidney-injury-acute-kidney-injury-still-misunderstood-and-misdiagnosed
#13
Prasad Devarajan
No abstract text is available yet for this article.
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28163309/acute-kidney-injury-aki-the-myth-of-inevitability-is-finally-shattered
#14
John A Kellum
No abstract text is available yet for this article.
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28138130/physical-inactivity-a-risk-factor-and-target-for-intervention-in-renal-care
#15
REVIEW
Dorien M Zelle, Gerald Klaassen, Edwin van Adrichem, Stephan J L Bakker, Eva Corpeleijn, Gerjan Navis
Regular physical activity is associated with an increased quality of life and reduced morbidity and mortality in the general population and in patients with chronic kidney disease (CKD). Physical activity, cardiorespiratory fitness, and muscle mass decrease even in the early stages of CKD, and continue to decrease with disease progression; notably, full recovery is generally not achieved with transplantation. The combined effects of uraemia and physical inactivity drive the loss of muscle mass. Regular physical activity benefits cardiometabolic, neuromuscular and cognitive function across all stages of CKD, and therefore provides an approach to address the multimorbidity of the CKD population...
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28138128/understanding-and-preventing-contrast-induced-acute-kidney-injury
#16
REVIEW
Michael Fähling, Erdmann Seeliger, Andreas Patzak, Pontus B Persson
Contrast-induced acute kidney injury (CIAKI) occurs in up to 30% of patients who receive iodinated contrast media and is generally considered to be the third most common cause of hospital-acquired AKI. Accurate assessment of the incidence of CIAKI is obscured, however, by the use of various definitions for diagnosis, the different populations studied and the prophylactic measures put in place. A deeper understanding of the mechanisms that underlie CIAKI is required to enable reliable risk assessment for individual patients, as their medical histories will determine the specific pathways by which contrast media administration might lead to kidney damage...
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28090083/kidney-disease-and-obesity-epidemiology-mechanisms-and-treatment
#17
REVIEW
Niels Olsen Saraiva Câmara, Kunitoshi Iseki, Holly Kramer, Zhi-Hong Liu, Kumar Sharma
The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed...
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28090081/metabolic-reprogramming-and-tolerance-during-sepsis-induced-aki
#18
REVIEW
Hernando Gómez, John A Kellum, Claudio Ronco
The host defence against infection is an adaptive response in which several mechanisms are deployed to decrease the pathogen load, limit tissue injury and restore homeostasis. In the past few years new evidence has suggested that the ability of the immune system to limit the microbial burden - termed resistance - might not be the only defence mechanism. In fact, the capacity of the host to decrease its own susceptibility to inflammation- induced tissue damage - termed tolerance - might be as important as resistance in determining the outcome of the infection...
March 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029154/changes-in-the-worldwide-epidemiology-of-peritoneal-dialysis
#19
REVIEW
Philip Kam-Tao Li, Kai Ming Chow, Moniek W M Van de Luijtgaarden, David W Johnson, Kitty J Jager, Rajnish Mehrotra, Sarala Naicker, Roberto Pecoits-Filho, Xue Qing Yu, Norbert Lameire
As the global burden of chronic kidney disease continues to increase, so does the need for a cost-effective renal replacement therapy. In many countries, patient outcomes with peritoneal dialysis are comparable to or better than those with haemodialysis, and peritoneal dialysis is also more cost-effective. These benefits have not, however, always led to increased utilization of peritoneal dialysis. Use of this therapy is increasing in some countries, including China, the USA and Thailand, but has proportionally decreased in parts of Europe and in Japan...
February 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28029153/cellular-senescence-in-renal-ageing-and-disease
#20
REVIEW
Ines Sturmlechner, Matej Durik, Cynthia J Sieben, Darren J Baker, Jan M van Deursen
The senescence programme is implicated in diverse biological processes, including embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo studies of senescence are in their infancy, evidence suggesting that senescent cells are a heterogeneous cell type is accumulating: senescence can be induced by different stressors, and senescent cells have varying degrees of genomic and epigenomic instability and different cell origins, contributing to their diversity. Two main classes of senescent cells have been identified: acute and chronic senescent cells...
February 2017: Nature Reviews. Nephrology
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