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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/30209359/targeting-methylation
#1
Susan J Allison
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30209358/sweet-success-for-ccrcc-isotope-tracing
#2
Caroline Barranco
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30206339/hla-and-kidney-disease-from-associations-to-mechanisms
#3
REVIEW
Kate J Robson, Joshua D Ooi, Stephen R Holdsworth, Jamie Rossjohn, A Richard Kitching
Since the first association between HLA and diseases of native kidneys was described almost 50 years ago, technological and conceptual advances in HLA biology and typing, together with better case ascertainment, have led to an improved understanding of HLA associations with a variety of renal diseases. A substantial body of evidence now supports the existence of HLA genetic associations in the field of renal disease beyond the role of HLA in allogeneic responses in transplant recipients. Allomorphs of HLA have emerged as important risk factors in most immune-mediated renal diseases, which, together with other genetic and environmental factors, lead to loss of tolerance and autoimmune-mediated renal inflammation...
September 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30171208/augmenting-nad-may-combat-kidney-stress
#4
Ellen F Carney
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30171207/renoprotective-effects-of-dulaglutide-in-patients-with-t2dm-and-ckd
#5
Charlotte M Sorensen, Jens J Holst
No abstract text is available yet for this article.
August 31, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30166605/glp1-fragments-protect-the-kidney
#6
Monica Wang
No abstract text is available yet for this article.
August 30, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30143788/the-odyssey-of-risk-stratification-in-acute-kidney-injury
#7
Faeq Husain-Syed, Claudio Ronco
No abstract text is available yet for this article.
August 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30143787/circadian-rhythms-and-the-kidney
#8
REVIEW
Dmitri Firsov, Olivier Bonny
Numerous physiological functions exhibit substantial circadian oscillations. In the kidneys, renal plasma flow, the glomerular filtration rate and tubular reabsorption and/or secretion processes have been shown to peak during the active phase and decline during the inactive phase. These functional rhythms are driven, at least in part, by a self-sustaining cellular mechanism termed the circadian clock. The circadian clock controls different cellular functions, including transcription, translation and protein post-translational modifications (such as phosphorylation, acetylation and ubiquitylation) and degradation...
August 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30135570/global-epidemiology-and-outcomes-of-acute-kidney-injury
#9
REVIEW
Eric A J Hoste, John A Kellum, Nicholas M Selby, Alexander Zarbock, Paul M Palevsky, Sean M Bagshaw, Stuart L Goldstein, Jorge Cerdá, Lakhmir S Chawla
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various aetiologies and pathophysiological processes leading to decreased kidney function. In addition to retention of waste products, impaired electrolyte homeostasis and altered drug concentrations, AKI induces a generalized inflammatory response that affects distant organs. Full recovery of kidney function is uncommon, which leaves these patients at risk of long-term morbidity and death. Estimates of AKI prevalence range from <1% to 66%...
August 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30120380/metabolism-and-mitochondria-in-polycystic-kidney-disease-research-and-therapy
#10
REVIEW
Valeria Padovano, Christine Podrini, Alessandra Boletta, Michael J Caplan
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially lethal, monogenic diseases and is caused predominantly by mutations in polycystic kidney disease 1 (PKD1) and PKD2, which encode polycystin 1 (PC1) and PC2, respectively. Over the decades-long course of the disease, patients develop large fluid-filled renal cysts that impair kidney function, leading to end-stage renal disease in ~50% of patients. Despite the identification of numerous dysregulated pathways in ADPKD, the molecular mechanisms underlying the renal dysfunction from mutations in PKD genes and the physiological functions of the polycystin proteins are still unclear...
August 17, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30093695/m-regs-kick-start-transplant-tolerance
#11
Grant Otto
No abstract text is available yet for this article.
August 9, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30089813/precision-gene-editing-technology-and-applications-in-nephrology
#12
REVIEW
Zachary WareJoncas, Jarryd M Campbell, Gabriel Martínez-Gálvez, William A C Gendron, Michael A Barry, Peter C Harris, Caroline R Sussman, Stephen C Ekker
The expanding field of precision gene editing is empowering researchers to directly modify DNA. Gene editing is made possible using synonymous technologies: a DNA-binding platform to molecularly locate user-selected genomic sequences and an associated biochemical activity that serves as a functional editor. The advent of accessible DNA-targeting molecular systems, such as zinc-finger nucleases, transcription activator-like effectors (TALEs) and CRISPR-Cas9 gene editing systems, has unlocked the ability to target nearly any DNA sequence with nucleotide-level precision...
August 8, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30065257/lymph-node-fibrosis-after-ischaemic-injury
#13
Monica Wang
No abstract text is available yet for this article.
July 31, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30042436/breaches-in-the-bowman-s-capsule-and-cd8-t-cell-infiltration-in-crescentic-gn
#14
Susan J Allison
No abstract text is available yet for this article.
July 24, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30030489/single-cell-analysis-of-a-biopsy-sample
#15
Ellen F Carney
No abstract text is available yet for this article.
July 20, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29995834/hedgehog-tgf%C3%AE-signalling-controls-nephrogenesis
#16
Grant Otto
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29995833/pivotal-role-of-camk4-in-podocyte-injury
#17
Ellen F Carney
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29980772/renal-denervation-one-step-backwards-three-steps-forward
#18
Markus P Schlaich, George L Bakris
No abstract text is available yet for this article.
July 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29973730/the-role-of-nephrectomy-in-metastatic-renal-cell-carcinoma
#19
Viktor Grünwald, Axel Bex
No abstract text is available yet for this article.
July 4, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/30072710/intravenous-fluid-therapy-in-critically-ill-adults
#20
REVIEW
Simon Finfer, John Myburgh, Rinaldo Bellomo
Intravenous fluid therapy is one of the most common interventions in acutely ill patients. Each day, over 20% of patients in intensive care units (ICUs) receive intravenous fluid resuscitation, and more than 30% receive fluid resuscitation during their first day in the ICU. Virtually all hospitalized patients receive intravenous fluid to maintain hydration and as diluents for drug administration. Until recently, the amount and type of fluids administered were based on a theory described over 100 years ago, much of which is inconsistent with current physiological data and emerging knowledge...
September 2018: Nature Reviews. Nephrology
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