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Nature Reviews. Nephrology

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https://www.readbyqxmd.com/read/28713167/cell-biology-connexin-connections-in-gn
#1
Grant Otto
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28713166/infection-impeding-upec-gut-colonization
#2
Clemens Thoma
No abstract text is available yet for this article.
July 17, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669992/treatment-of-membranous-nephropathy-time-for-a-paradigm-shift
#3
REVIEW
Piero Ruggenenti, Fernando C Fervenza, Giuseppe Remuzzi
In patients with membranous nephropathy, alkylating agents (cyclophosphamide or chlorambucil) alone or in combination with steroids achieve remission of nephrotic syndrome more effectively than conservative treatment or steroids alone, but can cause myelotoxicity, infections, and cancer. Calcineurin inhibitors can improve proteinuria, but are nephrotoxic. Most patients relapse after treatment withdrawal and can become treatment dependent, which increases the risk of nephrotoxicity. The discovery of nephritogenic autoantibodies against podocyte M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain- containing protein 7A (THSD7A) antigens provides a clear pathophysiological rationale for interventions that specifically target B-cell lineages to prevent antibody production and subepithelial deposition...
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669991/polycystic-kidney-disease-smyd2-is-a-novel-epigenetic-regulator-of-cyst-growth
#4
Andrea Aguilar
No abstract text is available yet for this article.
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669990/chronic-kidney-disease-role-of-supar-in-apol1-associated-kidney-disease
#5
Ellen F Carney
No abstract text is available yet for this article.
July 3, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28691713/targeted-therapies-for-renal-cell-carcinoma
#6
REVIEW
Edwin M Posadas, Suwicha Limvorasak, Robert A Figlin
The management of patients with metastatic renal cell carcinoma (RCC) has changed dramatically over the past few years. Nephrectomy remains an important intervention for localized RCC but systemic therapy is the mainstay of treatment for patients who relapse after surgery or who have metastatic RCC. Before 2005, medical therapies for RCC were limited to cytokine therapies, which are very toxic and benefit only a small percentage of patients. In 2017, therapeutic agents now include kinase and immune checkpoint inhibitors...
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669995/redefining-lupus-nephritis-clinical-implications-of-pathophysiologic-subtypes
#7
REVIEW
Feng Yu, Mark Haas, Richard Glassock, Ming-Hui Zhao
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and immunologic manifestations, of which lupus nephritis is the most common cause of morbidity and mortality. The development of nephritis in patients with SLE involves multiple pathogenic pathways including aberrant apoptosis, autoantibody production, immune complex deposition and complement activation. The 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification system for lupus nephritis was widely accepted with high intraobserver and interobserver concordance to guide therapeutic strategy and provide prognostic information...
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669994/cardiovascular-disease-pcsk9-inhibition-a-new-player-in-cholesterol-lowering-therapies
#8
David Preiss, Colin Baigent
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28669993/the-5-phosphatase-ocrl-in-lowe-syndrome-and-dent-disease-2
#9
REVIEW
Maria Antonietta De Matteis, Leopoldo Staiano, Francesco Emma, Olivier Devuyst
Lowe syndrome is an X-linked disease that is characterized by congenital cataracts, central hypotonia, intellectual disability and renal Fanconi syndrome. The disease is caused by mutations in OCRL, which encodes an inositol polyphosphate 5-phosphatase (OCRL) that acts on phosphoinositides - quantitatively minor constituents of cell membranes that are nonetheless pivotal regulators of intracellular trafficking. In this Review we summarize the considerable progress made over the past decade in understanding the cellular roles of OCRL in regulating phosphoinositide balance along the endolysosomal pathway, a fundamental system for the reabsorption of proteins and solutes by proximal tubular cells...
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28649125/glomerular-filtration-rate-ckd-risk-factors-are-associated-with-increased-single-nephron-gfr
#10
Ellen F Carney
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28626223/development-tfcp2l1-drives-notch-signalling-and-epithelial-diversity-in-the-collecting-duct
#11
Andrea Aguilar
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28626222/the-role-of-epigenetics-in-renal-ageing
#12
REVIEW
Paul G Shiels, Dagmara McGuinness, Maria Eriksson, Jeroen P Kooman, Peter Stenvinkel
An ability to separate natural ageing processes from processes specific to morbidities is required to understand the heterogeneity of age-related organ dysfunction. Mechanistic insight into how epigenetic factors regulate ageing throughout the life course, linked to a decline in renal function with ageing, is already proving to be of value in the analyses of clinical and epidemiological cohorts. Noncoding RNAs provide epigenetic regulatory circuits within the kidney, which reciprocally interact with DNA methylation processes, histone modification and chromatin...
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28626221/epidemiology-the-global-burden-of-reduced-gfr-esrd-cvd-and-mortality
#13
Shilpa Sharma, Mark J Sarnak
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603277/acute-kidney-injury-targeting-treg-cells-to-protect-the-kidney
#14
Ellen F Carney
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603276/onconephrology-new-mouse-model-of-clear-cell-renal-cell-carcinoma
#15
Ellen F Carney
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603275/development-pax2-keeps-nephron-progenitors-on-track
#16
Andrea Aguilar
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603274/lupus-nephritis-role-of-nlrp3-inflammasomes-in-podocyte-injury
#17
Ellen F Carney
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603273/transplantation-survival-benefit-of-accepting-a-diabetic-deceased-donor-kidney
#18
Ellen F Carney
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28603272/podocyte-biology-the-podocyte-adhesome
#19
Susan J Allison
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28579614/cystic-kidney-disease-a-new-osmoregulatory-role-for-hnf-1%C3%AE
#20
Andrea Aguilar
No abstract text is available yet for this article.
August 2017: Nature Reviews. Nephrology
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