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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/27904145/rheumatoid-arthritis-modelling-cytokine-signalling-networks
#1
Daehee Hwang, Wan-Uk Kim
No abstract text is available yet for this article.
December 1, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27904144/causes-and-consequences-of-endoplasmic-reticulum-stress-in-rheumatic-disease
#2
REVIEW
Fatemeh Navid, Robert A Colbert
Rheumatic diseases represent a heterogeneous group of inflammatory conditions, many of which involve chronic activation of both innate and adaptive immune responses by multiple genetic and environmental factors. These immune responses involve the secretion of excessive amounts of cytokines and other signalling mediators by activated immune cells. The endoplasmic reticulum (ER) is the cellular organelle that directs the folding, processing and trafficking of membrane-bound and secreted proteins, including many key components of the immune response...
December 1, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27904143/osteoarthritis-gdf5-modifies-disease-in-oa-rat-model
#3
Jessica McHugh
No abstract text is available yet for this article.
December 1, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27881864/mass-spectrometry-imaging-a-novel-technology-in-rheumatology
#4
REVIEW
Beatriz Rocha, Cristina Ruiz-Romero, Francisco J Blanco
Mass spectrometry imaging (MSI) is used to determine the relative abundance and spatial distribution of biomolecules such as peptides, proteins, lipids and other organic compounds in tissue sections by their molecular masses. This technique provides a sensitive and label-free approach for high-resolution imaging, and is currently used in an increasing number of biomedical applications such as biomarker discovery, tissue classification and drug monitoring. Owing to technological advances in the past 5 years in diverse MSI strategies, this technology is expected to become a standard tool in clinical practice and provides information complementary to that obtained using existing methods...
November 24, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27881863/epidemiology-the-effects-of-aids-on-the-prevalence-of-rheumatic-diseases
#5
Chak-Sing Lau, Philip Li
No abstract text is available yet for this article.
November 24, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27881862/rheumatoid-arthritis-il-23-assists-the-transition-from-autoimmunity-to-inflammatory-disease
#6
M Teresa Villanueva
No abstract text is available yet for this article.
November 24, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27881861/regenerative-medicine-engineered-ipscs-for-cartilage-repair
#7
Dario Ummarino
No abstract text is available yet for this article.
November 24, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27853280/experimental-arthritis-stopping-neutrophil-migration-in-its-tracks
#8
Joanna Collison
No abstract text is available yet for this article.
November 17, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829677/undifferentiated-arthritis-abatacept-for-treating-acpa-negative-ua
#9
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829676/autoimmunity-could-early-biologics-prevent-disease
#10
Caroline Barranco
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829675/guidelines-consort-statement-extended-for-pilot-trials
#11
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829673/rheumatoid-arthritis-bone-healing-effects-of-denosumab-in-ra
#12
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829672/management-of-psoriatic-arthritis-in-2016-a-comparison-of-eular-and-grappa-recommendations
#13
REVIEW
Laure Gossec, Laura C Coates, Maarten de Wit, Arthur Kavanaugh, Sofia Ramiro, Philip J Mease, Christopher T Ritchlin, Désirée van der Heijde, Josef S Smolen
Psoriatic arthritis (PsA) is a heterogeneous, potentially severe disease. Many therapeutic agents are now available for PsA, but treatment decisions are not always straightforward. To assist in this decision making, two sets of recommendations for the management of PsA were published in 2016 by international organizations - the European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). In both sets of recommendations, the heterogeneity of PsA is recognized and the place of various drugs in the therapeutic armamentarium is discussed...
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829671/adenosine-and-adenosine-receptors-in-the-pathogenesis-and-treatment-of-rheumatic-diseases
#14
REVIEW
Bruce N Cronstein, Michail Sitkovsky
Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on inflammatory cells by engaging one or more cell-surface receptors. The expression and function of adenosine receptors on different cell types change during the course of rheumatic diseases, such as rheumatoid arthritis (RA). Targeting adenosine receptors directly for the treatment of rheumatic diseases is currently under study; however, indirect targeting of adenosine receptors by enhancing adenosine levels at inflamed sites accounts for most of the anti-inflammatory effects of methotrexate, the anchor drug for the treatment of RA...
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27811914/update-on-the-genetic-architecture-of-rheumatoid-arthritis
#15
REVIEW
Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Sang-Cheol Bae
Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic loci associated with susceptibility to RA and have refined the RA-association model for HLA variants. The majority of RA-risk variants are highly shared across multiple ancestral populations and are located in noncoding elements that might have allele-specific regulatory effects in relevant tissues. Emerging multi-omics data, high-density genotype data and bioinformatic approaches are enabling researchers to use RA-risk variants to identify functionally relevant cell types and biological pathways that are involved in impaired immune processes and disease phenotypes...
November 4, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27811913/rheumatoid-arthritis-sedentary-behaviour-in-ra-a-new-research-agenda
#16
Sally A M Fenton, George D Kitas
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27784893/connective-tissue-diseases-remission-in-sle-are-we-there-yet
#17
Eric F Morand
No abstract text is available yet for this article.
October 27, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27784892/connective-tissue-diseases-new-cellular-players-in-sj%C3%A3-gren-syndrome-pathogenesis
#18
Jessica McHugh
No abstract text is available yet for this article.
October 27, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27784891/mechanism-of-action-of-methotrexate-in-rheumatoid-arthritis-and-the-search-for-biomarkers
#19
REVIEW
Philip M Brown, Arthur G Pratt, John D Isaacs
The treatment and outcomes of patients with rheumatoid arthritis (RA) have been transformed over the past two decades. Low disease activity and remission are now frequently achieved, and this success is largely the result of the evolution of treatment paradigms and the introduction of new therapeutic agents. Despite the rapid pace of change, the most commonly used drug in RA remains methotrexate, which is considered the anchor drug for this condition. In this Review, we describe the known pharmacokinetic properties and putative mechanisms of action of methotrexate...
October 27, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27784890/rheumatoid-arthritis-dna-repair-links-t-cell-ageing-to-inflammation
#20
Dario Ummarino
No abstract text is available yet for this article.
October 27, 2016: Nature Reviews. Rheumatology
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