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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/29765137/neurobiological-similarities-between-ra-and-fibromyalgia
#1
Fabiola Atzeni, Piercarlo Sarzi-Puttini
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29760436/fyn-ding-a-target-for-oa-therapy
#2
Nicholas J Bernard
No abstract text is available yet for this article.
May 14, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29760435/biomarkers-as-drug-development-tools-discovery-validation-qualification-and-use
#3
REVIEW
Virginia B Kraus
The 21st Century Cures Act, approved in the USA in December 2016, has encouraged the establishment of the national Precision Medicine Initiative and the augmentation of efforts to address disease prevention, diagnosis and treatment on the basis of a molecular understanding of disease. The Act adopts into law the formal process, developed by the FDA, of qualification of drug development tools, including biomarkers and clinical outcome assessments, to increase the efficiency of clinical trials and encourage an era of molecular medicine...
May 14, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29760434/multimerized-igg1-fc-molecule-as-an-anti-inflammatory-agent
#4
Emmanuel Stephen-Victor, Jagadeesh Bayry
No abstract text is available yet for this article.
May 14, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752462/the-role-of-radiography-and-mri-for-eligibility-assessment-in-dmoad-trials-of-knee-oa
#5
REVIEW
Frank W Roemer, C Kent Kwoh, Daichi Hayashi, David T Felson, Ali Guermazi
Currently, no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Past clinical trials have failed for several reasons, including the commonly applied definition of eligibility based on radiographic assessment of joint structure. In the context of precision medicine, finding the appropriate patient for a specific treatment approach will be of increasing relevance. Phenotypic stratification by use of imaging at the time of determining eligibility for clinical trials will be paramount and cannot be achieved using radiography alone...
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752461/axial-disease-in-psoriatic-arthritis-and-ankylosing-spondylitis-a-critical-comparison
#6
REVIEW
Joy Feld, Vinod Chandran, Nigil Haroon, Robert Inman, Dafna Gladman
Ankylosing spondylitis (AS) was first identified in the late 17th century. 250 years later, inflammatory spine disease was recognized to be one of the patterns of psoriatic arthritis (PsA). Isolated spondylitis is rare among patients with PsA, occurring in less than 5% of patients; however, many patients with PsA have axial disease that is concurrent with peripheral arthritis. At the other end of the spondyloarthritis spectrum, psoriasis is observed in 10% of patients with AS. Although axial involvement in PsA can be indistinguishable from axial disease in AS, it can also differ in several respects, raising the question of whether axial PsA and AS (with or without psoriasis) are different clinical presentations of the same disease, or whether they are separate diseases that have overlapping features...
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752460/rna-sequencing-and-machine-learning-as-molecular-scalpels
#7
Myles J Lewis, Michael R Barnes
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752459/synergy-of-environmental-and-genetic-risk-in-ra
#8
Nicholas J Bernard
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29752458/denosumab-shows-promise-for-giop
#9
Sarah Onuora
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29748637/flares-not-linked-to-ultrasound-findings-in-jia
#10
Sarah Onuora
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29748636/obesity-hampers-effects-of-anti-tnf-agents
#11
Sarah Onuora
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29748635/triple-therapy-boosts-survival-in-catastrophic-aps
#12
Sarah Onuora
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29743628/drugs-deliver-themselves-during-flares
#13
Joanna Collison
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29743627/arthritis-gene-therapy-is-becoming-a-reality
#14
Christopher H Evans, Steven C Ghivizzani, Paul D Robbins
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29740155/an-update-on-the-genetics-of-hyperuricaemia-and-gout
#15
REVIEW
Tanya J Major, Nicola Dalbeth, Eli A Stahl, Tony R Merriman
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to the formation of monosodium urate crystals. The clinical features of gout result from an individual's immune response to these deposited crystals. Genome-wide association studies (GWAS) have confirmed the importance of urate excretion in the control of serum urate levels and the risk of gout and have identified the kidneys, the gut and the liver as sites of urate regulation. The genetic contribution to the progression from hyperuricaemia to gout remains relatively poorly understood, although genes encoding proteins that are involved in the NLRP3 (NOD-, LRR- and pyrin domain-containing 3) inflammasome pathway play a part...
May 8, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29717259/surprising-safety-outcomes-of-urate-lowering-therapy
#16
Jessica McHugh
No abstract text is available yet for this article.
May 1, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29691493/bacterial-orthologues-of-ro60-trigger-disease
#17
Joanna Collison
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29686327/optimization-of-cvd-prevention-in-psoriatic-arthritis
#18
Anne Grete Semb, Silvia Rollefstad
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29686326/selective-p38%C3%AE-mapk-inhibitor-shows-promise
#19
Jessica McHugh
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29670212/mitochondrial-dna-variation-and-the-pathogenesis-of-osteoarthritis-phenotypes
#20
REVIEW
Francisco J Blanco, Ana M Valdes, Ignacio Rego-Pérez
Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses of the cell, and also regulate different processes involved in the pathogenesis of OA including inflammation, apoptosis, calcium metabolism and the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Mitochondria contain their own genetic material, mtDNA, which evolved through the sequential accumulation of mtDNA variants to enable humans to adapt to different climates...
April 18, 2018: Nature Reviews. Rheumatology
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