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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28084326/alzheimer-disease-in-2016-putting-ad-treatments-and-biomarkers-to-the-test
#1
Eric M Reiman
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28084325/alzheimer-disease-soluble-trem2-in-csf-sheds-light-on-microglial-activation-in-ad
#2
Heather Wood
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28084324/cns-infections-in-2016-2016-the-year-of-zika-virus
#3
Diederik van de Beek, Matthijs C Brouwer
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28084323/movement-disorders-in-2016-progress-in-parkinson-disease-and-other-movement-disorders
#4
Joseph Jankovic
No abstract text is available yet for this article.
January 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077868/rheumatoid-arthritis-tak-ing-the-road-to-suppress-inflammation-in-synovial-fibroblasts
#5
Mojca Frank-Bertoncelj, Steffen Gay
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077867/microbiome-in-2016-t-follicular-helper-cells-and-the-gut-microbiome-in-arthritis
#6
Veena Taneja
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077866/paediatric-rheumatic-disease-systemic-jia-genetically-distinct
#7
Sarah Onuora
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077865/systemic-sclerosis-in-2016-dermal-white-adipose-tissue-implicated-in-ssc-pathogenesis
#8
John Varga, Roberta G Marangoni
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053336/leptin-in-the-interplay-of-inflammation-metabolism-and-immune-system-disorders
#9
REVIEW
Vanessa Abella, Morena Scotece, Javier Conde, Jesús Pino, Miguel Angel Gonzalez-Gay, Juan J Gómez-Reino, Antonio Mera, Francisca Lago, Rodolfo Gómez, Oreste Gualillo
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a central regulator in energy homeostasis has been largely described during the past 20 years. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (LEPR), regulating appetite and food intake, bone mass, basal metabolism, reproductive function and insulin secretion, among other processes...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053335/an-fda-perspective-on-the-assessment-of-proposed-biosimilar-therapeutic-proteins-in-rheumatology
#10
REVIEW
Nikolay P Nikolov, Marjorie A Shapiro
Biologic products have revolutionized the management of many rheumatic diseases, but access to these products might be limited by their relatively high costs. The US Biologics Price Competition and Innovation Act of 2009, which is contained within the Patient Protection and Affordable Care Act, established an abbreviated pathway for licensure by the FDA of biologic products that are demonstrated to be biosimilar to or interchangeable with FDA-licensed biologic products, termed reference products. This law allows for the approval of biosimilar biologic products, which are expected to increase access to treatment for patients, and ensuring the implementation of this Act is a high priority for the FDA...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053334/rheumatoid-arthritis-new-model-linking-periodontitis-and-ra
#11
Jessica McHugh
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053333/connective-tissue-disease-reflections-on-the-eular-recommendations-for-the-treatment-of-systemic-sclerosis
#12
Janet E Pope
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053332/regenerative-medicine-in-2016-important-milestones-on-the-way-to-clinical-translation
#13
Daniel A Grande
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053331/immune-resolution-mechanisms-in-inflammatory-arthritis
#14
REVIEW
Mauro Perretti, Dianne Cooper, Jesmond Dalli, Lucy V Norling
The past two decades have witnessed major advancements in the clinical management of inflammatory arthritis, with new treatment strategies in some cases providing a marked improvement in patient outcomes. However, it is widely accepted that current strategies do not provide the 'total therapeutic solution', in view of the proportion of patients who do not respond to therapy, the important incidence of adverse effects and the development of an immune response against antibodies or fusion proteins used therapeutically...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053330/systemic-lupus-erythematosus-in-2016-gene-expression-profiling-comes-closer-to-the-clinic
#15
Guillermo Barturen, Marta E Alarcón-Riquelme
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28003641/systemic-lupus-erythematosus-inkt-cells-guard-the-heart-against-disease
#16
Joanna Collison
No abstract text is available yet for this article.
December 22, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27974851/mechanisms-leading-from-systemic-autoimmunity-to-joint-specific-disease-in-rheumatoid-arthritis
#17
REVIEW
Anca I Catrina, Camilla I Svensson, Vivianne Malmström, Georg Schett, Lars Klareskog
A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive RA (that is, characterized by the presence of autoantibodies) evidence is accumulating that immunity against post-translationally modified (such as citrullinated) autoantigens might be triggered in mucosal organs, such as the lung, long before the first signs of inflammation are seen in the joints. However, the mechanism by which systemic autoimmunity specifically homes to the joint and bone compartment, thereby triggering inflammation, remains elusive...
December 15, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829677/undifferentiated-arthritis-abatacept-for-treating-acpa-negative-ua
#18
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829675/guidelines-consort-statement-extended-for-pilot-trials
#19
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27829673/rheumatoid-arthritis-bone-healing-effects-of-denosumab-in-ra
#20
Jessica McHugh
No abstract text is available yet for this article.
November 10, 2016: Nature Reviews. Rheumatology
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