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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/30401979/hydroxychloroquine-retinopathy-implications-of-research-advances-for-rheumatology-care
#1
REVIEW
April Jorge, Cindy Ung, Lucy H Young, Ronald B Melles, Hyon K Choi
Despite advances in therapy for rheumatic diseases, hydroxychloroquine remains almost universally recommended for the treatment of systemic lupus erythematosus (SLE), and is often used in the management of other rheumatic diseases such as rheumatoid arthritis (RA). However, the major dose-limiting toxicity of hydroxychloroquine is retinopathy that can lead to loss of vision. New highly sensitive screening methods can identify early stages of retinopathy, and studies that include these modalities have indicated a substantially higher prevalence of hydroxychloroquine retinopathy than was previously recognized, resulting in revisions to ophthalmology guidelines and the recommendation of a low dose of hydroxychloroquine for many patients...
November 6, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390047/publisher-correction-b-cell-therapy-in-anca-associated-vasculitis-current-and-emerging-treatment-options
#2
Mark McClure, Seerapani Gopaluni, David Jayne, Rachel Jones
In the section 'Combining B cell-targeted therapies' in the originally published version of this article, the 24-week interim analysis for the CALIBRATE study was incorrectly given as the 2- to 4-week interim analysis. This error has now been corrected in the HTML and PDF versions of the manuscript.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390046/fat-pad-mri-signal-linked-to-oa-progression
#3
Joanna Collison
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390045/treat-to-target-possible-for-jia
#4
Joanna Collison
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390044/il-17a-blockade-effective-for-as
#5
Joanna Collison
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390043/infection-risk-with-tofacitinib-plus-glucocorticoid
#6
Joanna Collison
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30390042/inhibit-integrins-to-protect-cartilage
#7
Joanna Collison
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30367167/double-negative-b-cells
#8
Nicholas J Bernard
No abstract text is available yet for this article.
October 26, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30361674/nocebos-in-rheumatology-emerging-concepts-and-their-implications-for-clinical-practice
#9
REVIEW
Evrydiki Kravvariti, George D Kitas, Dimos D Mitsikostas, Petros P Sfikakis
Nocebo effects are noxious reactions to therapeutic interventions that occur because of negative expectations of the patient. In the past decade, neurobiological data have revealed specific neural pathways induced by nocebos (that is, interventions that cause nocebo effects), as well as the associated mechanisms and predisposing factors of nocebo effects. Epidemiological data suggest that nocebos can have a notable effect on medication adherence, clinical outcomes and health-care policy. Meta-analyses of randomized controlled trials (RCTs) of patients with rheumatic and musculoskeletal diseases (RMDs) indicate that withdrawal of treatment by placebo-arm participants owing to adverse events is common; a proportion of these events could be nocebo effects...
October 25, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30341437/anti-inflammatory-and-immune-regulatory-cytokines-in-rheumatoid-arthritis
#10
REVIEW
Zhu Chen, Aline Bozec, Andreas Ramming, Georg Schett
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and mediators that trigger RA have been the focus of intense investigations, the regulatory and anti-inflammatory cytokines responsible for the suppression and resolution of disease in a context-dependent manner have been less well characterized. However, knowledge of the pathways that control the suppression and resolution of inflammation in RA is clinically relevant and conceptually important for understanding the pathophysiology of the disease and for the development of treatments that enable long-term remission...
October 19, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30301938/the-microbiome-and-hla-b27-associated-acute-anterior-uveitis
#11
REVIEW
James T Rosenbaum, Mark Asquith
Acute anterior uveitis (AAU) and the spondyloarthritis (SpA) subtypes ankylosing spondylitis, reactive arthritis and psoriatic arthritis are among the inflammatory diseases affected by the biology of the intestinal microbiome. In this Review, the relationship between AAU, SpA and the microbiome is discussed, with a focus on the major SpA risk gene HLA-B*27 and how it is associated with both intestinal tolerance and the loss of ocular immune privilege that can accompany AAU. We provide four potential mechanisms to account for how dysbiosis, barrier function and immune response contribute to the development of ocular inflammation and the pathogenesis of AAU...
October 9, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30266977/effects-of-the-il-23-il-17-pathway-on-bone-in-spondyloarthritis
#12
REVIEW
Ellen M Gravallese, Georg Schett
Over the past several years, a pathophysiological role for the IL-23-IL-17 pathway in human disease has been defined. A subset of rheumatic diseases, including psoriatic arthritis (PsA) and ankylosing spondylitis (AS), are now acknowledged to be triggered by dysregulated IL-23-IL-17 pathway activation. Genetic evidence links the IL-23-IL-17 pathway to inflammation in these rheumatic diseases, and mechanistic data from mice support a functional role for IL-23-IL-17 pathway activation in the development of enthesitis and in entheseal bone formation...
September 28, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30266975/the-parallel-worlds-of-acpa-positive-and-rf-positive-b-cells
#13
Vivianne Malmström, Caroline Grönwall
No abstract text is available yet for this article.
September 28, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30242247/nanoparticles-in-neutrophil-clothing
#14
Joanna Collison
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30317249/author-correction-major-lung-complications-of-systemic-sclerosis
#15
Christopher P Denton, Athol U Wells, John G Coghlan
Corrections: Table 2: the text 'Also licensed for CTEPH; cannot be combined with a PDE5 inhibitor' has been moved to a different row; reference for this moved statement updated.
November 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30315243/potential-causal-variants-for-ra-identified
#16
Joanna Collison
No abstract text is available yet for this article.
November 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30310160/ace-inhibitors-preserve-cognitive-function
#17
Jessica McHugh
No abstract text is available yet for this article.
November 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30305701/hand-osteoarthritis-clinical-phenotypes-molecular-mechanisms-and-disease-management
#18
REVIEW
Michelle Marshall, Fiona E Watt, Tonia L Vincent, Krysia Dziedzic
Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This Review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management...
November 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30305700/new-insights-into-the-genetics-and-epigenetics-of-systemic-sclerosis
#19
REVIEW
Chiara Angiolilli, Wioleta Marut, Maarten van der Kroef, Eleni Chouri, Kris A Reedquist, Timothy R D J Radstake
Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and internal organs. The results of genetic studies in patients with SSc have revealed statistically significant genetic associations with disease manifestations and progression. Nevertheless, genetic susceptibility to SSc is moderate, and the functional consequences of genetic associations remain only partially characterized. A current hypothesis is that, in genetically susceptible individuals, epigenetic modifications constitute the driving force for disease initiation...
November 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30305699/dmard-related-adverse-events-lower-persistence
#20
Jessica McHugh
No abstract text is available yet for this article.
November 2018: Nature Reviews. Rheumatology
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