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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28931953/therapy-are-you-managing-osteoarthritis-appropriately
#1
David J Hunter, Jocelyn L Bowden
No abstract text is available yet for this article.
September 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905860/rheumatoid-arthritis-reducing-the-risk-of-herpes-zoster
#2
Jessica McHugh
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905859/clinical-trials-intravenous-golimumab-effective-for-psa
#3
Sarah Onuora
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905858/infection-infection-risk-after-switching-biologics
#4
Sarah Onuora
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905857/risk-factors-oral-contraceptive-use-linked-to-lower-risk-of-ra
#5
Sarah Onuora
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905856/position-paper-revised-2017-international-consensus-on-testing-of-ancas-in-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#6
REVIEW
Xavier Bossuyt, Jan-Willem Cohen Tervaert, Yoshihiro Arimura, Daniel Blockmans, Luis Felipe Flores-Suárez, Loïc Guillevin, Bernhard Hellmich, David Jayne, J Charles Jennette, Cees G M Kallenberg, Sergey Moiseev, Pavel Novikov, Antonella Radice, Judith Anne Savige, Renato Alberto Sinico, Ulrich Specks, Pieter van Paassen, Ming-Hui Zhao, Niels Rasmussen, Jan Damoiseaux, Elena Csernok
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications...
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905853/bone-targeting-old-cells-to-protect-old-bones
#7
Joanna Collison
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28878335/systemic-lupus-erythematosus-ox40l-expressing-b-cells-promote-sle
#8
Jessica McHugh
No abstract text is available yet for this article.
September 7, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28878334/vasculitis-syndromes-tocilizumab-a-new-frontier-for-gca-therapy
#9
Matthew J Koster, Kenneth J Warrington
No abstract text is available yet for this article.
September 7, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28855696/bone-towards-a-better-management-of-glucocorticoid-induced-osteoporosis
#10
René Rizzoli
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28855694/functional-autoantibodies-targeting-g-protein-coupled-receptors-in-rheumatic-diseases
#11
REVIEW
Otavio Cabral-Marques, Gabriela Riemekasten
G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of integral membrane proteins that participate in different physiological processes such as the regulation of the nervous and immune systems. Besides the endogenous ligands of GPCRs, functional autoantibodies are also able to bind GPCRs to trigger or block intracellular signalling pathways, resulting in agonistic or antagonistic effects, respectively. In this Review, the effects of functional GPCR-targeting autoantibodies on the pathogenesis of autoimmune diseases, including rheumatic diseases, are discussed...
August 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28855693/rheumatoid-arthritis-characterization-of-the-infrapatellar-fat-pad
#12
Liesbet Lieben
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28855691/immunology-balancing-immunoreceptor-signalling
#13
Jessica McHugh
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28835672/osteoporosis-discontinuing-denosumab-discouraged
#14
Joanna Collison
No abstract text is available yet for this article.
August 24, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28794513/rheumatoid-arthritis-dmard-de-escalation-let-the-patient-guide-you
#15
Yoshiya Tanaka
No abstract text is available yet for this article.
August 10, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28725036/paediatric-rheumatic-disease-what-is-the-best-definition-of-clinical-remission-in-jia
#16
Gabriella Giancane, Angelo Ravelli
This corrects the article DOI: 10.1038/nrrheum.2017.105.
July 20, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905861/giant-cell-arteritis-and-polymyalgia-rheumatica-current-challenges-and-opportunities
#17
REVIEW
Christian Dejaco, Elisabeth Brouwer, Justin C Mason, Frank Buttgereit, Eric L Matteson, Bhaskar Dasgupta
The fields of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) have advanced rapidly, resulting in a new understanding of these diseases. Fast-track strategies and improved awareness programmes that prevent irreversible sight loss through early diagnosis and treatment are a notable advance. Ultrasonography and other imaging techniques have been introduced into routine clinical practice and there have been promising reports on the efficacy of biologic agents, particularly IL-6 antagonists such as tocilizumab, in treating these conditions...
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905855/new-insights-into-the-epigenetics-of-inflammatory-rheumatic-diseases
#18
REVIEW
Esteban Ballestar, Tianlu Li
Over the past decade, awareness of the importance of epigenetic alterations in the pathogenesis of rheumatic diseases has grown in parallel with a general recognition of the fundamental role of epigenetics in the regulation of gene expression. Large-scale efforts to generate genome-wide maps of epigenetic modifications in different cell types, as well as in physiological and pathological contexts, illustrate the increasing recognition of the relevance of epigenetics. To date, although several reports have demonstrated the occurrence of epigenetic alterations in a wide range of inflammatory rheumatic conditions, epigenomic information is rarely used in a clinical setting...
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905854/pain-caution-needed-in-use-of-gabapentinoids-for-lbp
#19
Sarah Onuora
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28905852/differential-antibody-glycosylation-in-autoimmunity-sweet-biomarker-or-modulator-of-disease-activity
#20
REVIEW
Michaela Seeling, Christin Brückner, Falk Nimmerjahn
A loss of humoral tolerance is a hallmark of many autoimmune diseases and the detection of self-reactive antibodies (autoantibodies) of the immunoglobulin G (IgG) isotype is widely used as a biomarker and diagnostic tool. However, autoantibodies might also be present in individuals without autoimmune disease, thus limiting their usefulness as a sole indicator of disease development. Moreover, while clear evidence exists of the pathogenic effects of autoantibodies in mouse model systems, the contribution of autoantibodies to the pathology of many autoimmune diseases has yet to be established...
September 14, 2017: Nature Reviews. Rheumatology
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