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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28228650/haematopoietic-stem-cell-transplantation-for-autoimmune-diseases
#1
REVIEW
Joost F Swart, Eveline M Delemarre, Femke van Wijk, Jaap-Jan Boelens, Jürgen Kuball, Jacob M van Laar, Nico M Wulffraat
Autologous haematopoietic stem cell transplantation (HSCT) is the only treatment that is able to induce long-term, drug-free and symptom-free remission in several refractory autoimmune rheumatic diseases. Over 3,000 HSCT procedures for rheumatic and nonrheumatic severe autoimmune diseases have been performed worldwide. Specific conditioning regimens are currently used to eradicate the autoreactive immunological memory of patients. Although in vivo immune cell depletion with antithymocyte globulin or anti-CD52 is the norm for many regimens, ex vivo selection of CD34(+) stem cells from the graft is controversial...
February 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28228649/inflammation-hit-the-dek
#2
Sarah Onuora
No abstract text is available yet for this article.
February 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28228648/spondyloarthropathies-e-coli-links-ibd-to-spondyloarthritis
#3
Dario Ummarino
No abstract text is available yet for this article.
February 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28228647/spondyloarthropathies-fine-tuning-the-management-of-axial-spondyloarthritis
#4
Daniel Wendling, Clément Prati
No abstract text is available yet for this article.
February 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202916/rheumatoid-arthritis-new-player-in-ra-pathogenesis-brought-to-light
#5
Joanna Collison
No abstract text is available yet for this article.
February 16, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202915/acute-inflammatory-arthritis-potential-therapies-for-chikungunya-arthritis
#6
Jessica McHugh
No abstract text is available yet for this article.
February 16, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202911/what-rheumatologists-need-to-know-about-crispr-cas9
#7
REVIEW
Gary J Gibson, Maozhou Yang
CRISPR/Cas9 genome editing technology has taken the research world by storm since its use in eukaryotes was first proposed in 2012. Publications describing advances in technology and new applications have continued at an unrelenting pace since that time. In this Review, we discuss the application of CRISPR/Cas9 for creating gene mutations - the application that initiated the current avalanche of interest - and new developments that have largely answered initial concerns about its specificity and ability to introduce new gene sequences...
February 9, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077867/microbiome-in-2016-t-follicular-helper-cells-and-the-gut-microbiome-in-arthritis
#8
Veena Taneja
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28077865/systemic-sclerosis-in-2016-dermal-white-adipose-tissue-implicated-in-ssc-pathogenesis
#9
John Varga, Roberta G Marangoni
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053336/leptin-in-the-interplay-of-inflammation-metabolism-and-immune-system-disorders
#10
REVIEW
Vanessa Abella, Morena Scotece, Javier Conde, Jesús Pino, Miguel Angel Gonzalez-Gay, Juan J Gómez-Reino, Antonio Mera, Francisca Lago, Rodolfo Gómez, Oreste Gualillo
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a central regulator in energy homeostasis has been largely described during the past 20 years. Once secreted into the circulation, leptin reaches the central and peripheral nervous systems and acts by binding and activating the long form of leptin receptor (LEPR), regulating appetite and food intake, bone mass, basal metabolism, reproductive function and insulin secretion, among other processes...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053334/rheumatoid-arthritis-new-model-linking-periodontitis-and-ra
#11
Jessica McHugh
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053332/regenerative-medicine-in-2016-important-milestones-on-the-way-to-clinical-translation
#12
Daniel A Grande
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28053331/immune-resolution-mechanisms-in-inflammatory-arthritis
#13
REVIEW
Mauro Perretti, Dianne Cooper, Jesmond Dalli, Lucy V Norling
The past two decades have witnessed major advancements in the clinical management of inflammatory arthritis, with new treatment strategies in some cases providing a marked improvement in patient outcomes. However, it is widely accepted that current strategies do not provide the 'total therapeutic solution', in view of the proportion of patients who do not respond to therapy, the important incidence of adverse effects and the development of an immune response against antibodies or fusion proteins used therapeutically...
January 5, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28003641/systemic-lupus-erythematosus-inkt-cells-guard-the-heart-against-disease
#14
Joanna Collison
No abstract text is available yet for this article.
December 22, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27974851/mechanisms-leading-from-systemic-autoimmunity-to-joint-specific-disease-in-rheumatoid-arthritis
#15
REVIEW
Anca I Catrina, Camilla I Svensson, Vivianne Malmström, Georg Schett, Lars Klareskog
A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive RA (that is, characterized by the presence of autoantibodies) evidence is accumulating that immunity against post-translationally modified (such as citrullinated) autoantigens might be triggered in mucosal organs, such as the lung, long before the first signs of inflammation are seen in the joints. However, the mechanism by which systemic autoimmunity specifically homes to the joint and bone compartment, thereby triggering inflammation, remains elusive...
December 15, 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202920/cartilage-targeting-drug-delivery-can-electrostatic-interactions-help
#16
REVIEW
Ambika G Bajpayee, Alan J Grodzinsky
Current intra-articular drug delivery methods do not guarantee sufficient drug penetration into cartilage tissue to reach cell and matrix targets at the concentrations necessary to elicit the desired biological response. Here, we provide our perspective on the utilization of charge-charge (electrostatic) interactions to enhance drug penetration and transport into cartilage, and to enable sustained binding of drugs within the tissue's highly negatively charged extracellular matrix. By coupling drugs to positively charged nanocarriers that have optimal size and charge, cartilage can be converted from a drug barrier into a drug reservoir for sustained intra-tissue delivery...
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202919/ectopic-lymphoid-neogenesis-in-rheumatic-autoimmune-diseases
#17
REVIEW
Michele Bombardieri, Myles Lewis, Costantino Pitzalis
Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other connective tissue disorders, including systemic lupus erythematosus and myositis. However, the mechanisms of ectopic lymphoid-like structure (ELS) formation and function are not entirely understood. For example, it is unclear whether ELSs indicate distinct disease phenotypes or whether they are evolutionary manifestations of chronic inflammation...
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202918/paediatric-rheumatic-diseases-navigating-the-transition-from-paediatric-to-adult-care
#18
Erica F Lawson, Elizabeth D Mellins
No abstract text is available yet for this article.
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202917/autophagy-controlling-cell-fate-in-rheumatic-diseases
#19
Jason S Rockel, Mohit Kapoor
No abstract text is available yet for this article.
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28202914/osteoarthritis-ucma-links-cartilage-and-bone-in-oa
#20
Sarah Onuora
No abstract text is available yet for this article.
March 2017: Nature Reviews. Rheumatology
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