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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28701761/antigen-specific-immunotherapies-in-rheumatic-diseases
#1
REVIEW
Judit Pozsgay, Zoltán Szekanecz, Gabriella Sármay
The main goal of antigen-specific immunotherapy (ASI) in autoimmune and rheumatic diseases is to reprogramme or remove autoreactive cells and/or induce immune tolerance to self-antigens. Current therapies in these diseases either treat symptoms or slow down disease progression but are not yet curative or preventative - disease-specific treatments are urgently needed. In contrast to the nonspecific treatments in current use that induce generalized immune suppression, which is associated with several adverse effects including increased risk of infections, ASIs target a restricted subset of B cells or T cells, and thus do not compromise systemic immunity and host defence...
July 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28701760/synovial-tissue-research-a-state-of-the-art-review
#2
REVIEW
Carl Orr, Elsa Sousa, David L Boyle, Maya H Buch, Christopher D Buckley, Juan D Cañete, Anca I Catrina, Ernest H S Choy, Paul Emery, Ursula Fearon, Andrew Filer, Danielle Gerlag, Frances Humby, John D Isaacs, Søren A Just, Bernard R Lauwerys, Benoit Le Goff, Antonio Manzo, Trudy McGarry, Iain B McInnes, Aurélie Najm, Constantino Pitzalis, Arthur Pratt, Malcolm Smith, Paul P Tak, Rogier Thurlings, João E Fonseca, Douglas J Veale
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches...
July 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680137/sexual-and-reproductive-health-in-rheumatic-disease
#3
REVIEW
Monika Østensen
Family size is reduced among patients with rheumatic diseases. The causes for the low number of children are multifactorial and include impaired sexual function, decreased gonadal function, pregnancy loss, therapy and personal choices. Sexuality contributes to quality of life in patients with rheumatic disease, but is often ignored by health professionals. Both disease-related factors and psychological responses to chronic disease can impair sexual functioning. Toxic effects of anti-inflammatory and immunosuppressive drugs can induce transient or permanent gonadal failure in women and men...
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680136/systemic-lupus-erythematosus-ifn-drives-synapse-loss-via-microglia
#4
Jessica McHugh
No abstract text is available yet for this article.
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680135/rheumatoid-arthritis-jak-ing-up-inadequate-ra-therapy
#5
Sarah Onuora
No abstract text is available yet for this article.
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680134/surgery-falling-out-of-love-with-knee-arthroscopy
#6
Teppo L N Järvinen, Gordon H Guyatt
No abstract text is available yet for this article.
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680133/systemic-sclerosis-choosing-patients-wisely-when-treating-interstitial-lung-disease
#7
Richard M Silver
No abstract text is available yet for this article.
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28680132/visual-loss-and-other-cranial-ischaemic-complications-in-giant-cell-arteritis
#8
REVIEW
Alessandra Soriano, Francesco Muratore, Nicolò Pipitone, Luigi Boiardi, Luca Cimino, Carlo Salvarani
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals aged 50 years and over. GCA typically affects large and medium-sized arteries, with a predilection for the extracranial branches of the carotid artery. Patients with GCA usually present with symptoms and signs that are directly related to the artery that is affected, with or without constitutional manifestations. The most dreaded complication of GCA is visual loss, which affects about one in six patients and is typically caused by arteritis of the ophthalmic branches of the internal carotid artery...
July 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660916/rheumatoid-arthritis-the-benefits-of-early-treatment-after-decades
#9
Angela Zink, Katinka Albrecht
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660915/therapy-rheumatic-disease-after-immune-checkpoint-inhibitor-therapy
#10
Dario Ummarino
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660913/systemic-lupus-erythematosus-tackling-complexity-through-immunophenotyping
#11
Dario Ummarino
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660912/rheumatoid-arthritis-growing-role-for-pads-in-pathogenesis
#12
Joanna Collison
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660911/paediatric-rheumatic-disease-what-is-the-best-definition-of-clinical-remission-in-jia
#13
Gabriella Giancane, Angelo Ravelli
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660910/rheumatoid-arthritis-acpa-status-influences-ra-development
#14
Dario Ummarino
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660909/spondyloarthropathies-mif-drives-inflammation-and-bone-formation-in-as
#15
Sarah Onuora
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660908/crystal-arthritis-combination-therapy-effective-in-tophaceous-gout
#16
Dario Ummarino
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660914/immunology-inhibiting-autophagy-in-dendritic-cells
#17
Jessica McHugh
No abstract text is available yet for this article.
June 22, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28660907/systemic-lupus-erythematosus-the-promise-of-promis-is-it-ready-for-prime-time-in-sle
#18
Meenakshi Jolly, Patricia Katz
No abstract text is available yet for this article.
June 22, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28615729/systemic-lupus-erythematosus-baff-emerges-from-the-genetic-shadows
#19
William Stohl
No abstract text is available yet for this article.
June 15, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28592897/stem-cells-synovial-stem-cells-respond-to-a-yap
#20
Joanna Collison
No abstract text is available yet for this article.
June 8, 2017: Nature Reviews. Rheumatology
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