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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28615729/systemic-lupus-erytheumatosus-baff-emerges-from-the-genetic-shadows
#1
William Stohl
No abstract text is available yet for this article.
June 15, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28592897/stem-cells-synovial-stem-cells-respond-to-a-yap
#2
Joanna Collison
No abstract text is available yet for this article.
June 8, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28592896/lupus-nephritis-nlrp3-inflammasome-ignites-podocyte-dysfunction
#3
Dario Ummarino
No abstract text is available yet for this article.
June 8, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569267/biologics-registers-in-ra-methodological-aspects-current-role-and-future-applications
#4
REVIEW
Elena Nikiphorou, Maya H Buch, Kimme L Hyrich
The beginning of the 21st century saw a biopharmaceutical revolution in the treatment of inflammatory rheumatic diseases, particularly rheumatoid arthritis. The fast-evolving use of biologic therapies highlighted the need to develop registers at national and international levels with the aim of collecting long-term data on patient outcomes. Over the past 15 years, many biologics registers have contributed a wealth of data and provided robust and reliable evidence on the use, effectiveness and safety of these therapies...
June 1, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569266/pharmacotherapy-biosimilar-switching-to-set-a-form-upon-desired-change
#5
Jonathan Kay, Kevin L Winthrop
No abstract text is available yet for this article.
June 1, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569265/spondyloarthropathies-gut-bone-crosstalk-in-hla-b27-rats
#6
Joanna Collison
No abstract text is available yet for this article.
June 1, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569264/experimental-arthritis-flipping-the-switch-on-macrophages
#7
Jessica McHugh
No abstract text is available yet for this article.
June 1, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28569263/the-genetics-revolution-in-rheumatology-large-scale-genomic-arrays-and-genetic-mapping
#8
REVIEW
Stephen Eyre, Gisela Orozco, Jane Worthington
Susceptibility to rheumatic diseases, such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, juvenile idiopathic arthritis and psoriatic arthritis, includes a large genetic component. Understanding how an individual's genetic background influences disease onset and outcome can lead to a better understanding of disease biology, improved diagnosis and treatment, and, ultimately, to disease prevention or cure. The past decade has seen great progress in the identification of genetic variants that influence the risk of rheumatic diseases...
June 1, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541299/antinuclear-antibody-testing-misunderstood-or-misbegotten
#9
REVIEW
David S Pisetsky
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of rheumatic diseases, most prominently systemic lupus erythematosus (SLE), and ANA testing is commonly performed in the clinical setting. In addition, ANA testing is now used to assess eligibility for participation in clinical trials of new therapeutic agents for SLE. ANAs can be assayed by various techniques, with the fluorescent ANA assay often viewed as the gold standard...
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28490786/rheumatoid-arthritis-don-t-swallow-the-nets
#10
Dario Ummarino
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28381831/experimental-arthritis-il-38-promotes-anti-inflammatory-effects
#11
Dario Ummarino
No abstract text is available yet for this article.
April 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28381830/the-role-of-metabolism-in-the-pathogenesis-of-osteoarthritis
#12
REVIEW
Ali Mobasheri, Margaret P Rayman, Oreste Gualillo, Jérémie Sellam, Peter van der Kraan, Ursula Fearon
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis...
April 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360424/the-emerging-safety-profile-of-jak-inhibitors-in-rheumatic-disease
#13
Kevin L Winthrop
No abstract text is available yet for this article.
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360423/immunometabolism-in-systemic-lupus-erythematosus
#14
REVIEW
Laurence Morel
Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic autoantibodies directed against nucleoprotein complexes. Beyond the activation of autoreactive B cells, this process involves dysregulation in many other types of immune cells, including CD4(+) T cells, dendritic cells, macrophages and neutrophils. Metabolic substrate utilization and integration of cues from energy sensors are critical checkpoints of effector functions in the immune system, with common as well as cell-specific programmes...
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360422/immunometabolism-in-early-and-late-stages-of-rheumatoid-arthritis
#15
REVIEW
Cornelia M Weyand, Jörg J Goronzy
One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to proliferate, a property shared with the joint-resident cells that form the synovial pannus. The building of biomass imposes high demands for energy and biosynthetic precursors, implicating metabolic control as a basic disease mechanism. During preclinical RA, when autoreactive T cells expand and immunological tolerance is broken, the main sites of disease are the secondary lymphoid tissues. Naive CD4(+) T cells from patients with RA have a distinct metabolic signature, characterized by dampened glycolysis, low ATP levels and enhanced shunting of glucose into the pentose phosphate pathway...
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28615733/why-location-matters-site-specific-factors-in-rheumatic-diseases
#16
REVIEW
Caroline Ospelt, Mojca Frank-Bertoncelj
Rheumatic diseases follow a characteristic anatomical pattern of joint and organ involvement. This Review explores three interconnected mechanisms that might be involved in the predilection of specific joints for developing specific forms of arthritis: site-specific local cell types that drive disease; systemic triggers that affect local cell types; and site-specific exogenous factors, such as focal mechanical stress, that activate cells locally. The embryonic development of limbs and joints is also relevant to the propensity of certain joints to develop arthritis...
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28615732/managing-rheumatic-and-musculoskeletal-diseases-past-present-and-future
#17
REVIEW
Gerd R Burmester, Johannes W J Bijlsma, Maurizio Cutolo, Iain B McInnes
Progress in rheumatology has been remarkable in the past 70 years, favourably affecting quality of life for people with rheumatic and musculoskeletal diseases. Therapeutics have advanced considerably in this period, from early developments such as the introduction of glucocorticoid therapy to the general use of methotrexate and other disease-modifying agents, followed by the advent of biologic DMARDs and, most recently, small-molecule signalling inhibitors. Novel strategies for the use of such agents have also transformed outcomes, as have multidisciplinary nonpharmacological approaches to the management of rheumatic musculoskeletal disease including surgery, physical therapy and occupational therapy...
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28615731/the-role-of-il-6-in-host-defence-against-infections-immunobiology-and-clinical-implications
#18
REVIEW
Stefan Rose-John, Kevin Winthrop, Leonard Calabrese
IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of a host to respond to infections. Understanding the precise role of this cytokine in immunocompetence requires a critical appraisal of data derived from both preclinical and clinical studies. Primary immunodeficiency diseases involving IL-6 or its signalling pathways reveal that IL-6 is critical in the defence against numerous types of pathogens...
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28615730/pain-in-ankylosing-spondylitis-a-neuro-immune-collaboration
#19
REVIEW
Katayoon Bidad, Eric Gracey, Kasey S Hemington, Josiane C S Mapplebeck, Karen D Davis, Robert D Inman
Clinicians have commonly differentiated chronic back pain into two broad subsets: namely, non-inflammatory (or mechanical) back pain and inflammatory back pain. As the terminology suggests, the latter category, in which ankylosing spondylitis (AS) is prominent, presupposes a close link between pain and inflammation. Advances in research into the genetics and immunology of AS have improved our understanding of the inflammatory processes involved in this disease, and have led to the development of potent anti-inflammatory biologic therapeutic agents...
July 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28592895/spondyloarthropathies-targeting-il-17-in-refractory-psa
#20
Jessica McHugh
No abstract text is available yet for this article.
July 2017: Nature Reviews. Rheumatology
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