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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/28541299/antinuclear-antibody-testing-misunderstood-or-misbegotten
#1
REVIEW
David S Pisetsky
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of rheumatic diseases, most prominently systemic lupus erythematosus (SLE), and ANA testing is commonly performed in the clinical setting. In addition, ANA testing is now used to assess eligibility for participation in clinical trials of new therapeutic agents for SLE. ANAs can be assayed by various techniques, with the fluorescent ANA assay often viewed as the gold standard...
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541298/osteoarthritis-you-can-rely-on-radiography-when-managing-oa-but-not-too-much
#2
Ali Guermazi
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541297/risk-factors-susceptibility-allele-identified-in-rhd
#3
Dario Ummarino
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541296/autoinflammation-canakinumab-effective-in-hids-treatment
#4
Dario Ummarino
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541295/spondyloarthropathies-abatacept-treatment-for-psa
#5
Dario Ummarino
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541294/connective-tissue-diseases-mycobacterial-infection-and-sj%C3%A3-gren-syndrome
#6
Dario Ummarino
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28541293/immunology-hippo-signalling-influences-t-cell-fate
#7
Sarah Onuora
No abstract text is available yet for this article.
May 25, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28515462/autoimmunity-hla-mediated-protection-in-goodpasture-disease
#8
Ellen F Carney
No abstract text is available yet for this article.
May 18, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28490786/rheumatoid-arthritis-don-t-swallow-the-nets
#9
Dario Ummarino
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28490784/osteoarthritis-removing-old-chondrocytes-to-combat-disease
#10
Joanna Collison
No abstract text is available yet for this article.
May 11, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28381831/experimental-arthritis-il-38-promotes-anti-inflammatory-effects
#11
Dario Ummarino
No abstract text is available yet for this article.
April 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28381830/the-role-of-metabolism-in-the-pathogenesis-of-osteoarthritis
#12
REVIEW
Ali Mobasheri, Margaret P Rayman, Oreste Gualillo, Jérémie Sellam, Peter van der Kraan, Ursula Fearon
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to a highly metabolically activate state to maintain energy homeostasis. This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis...
April 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28381828/rheumatoid-arthritis-the-ins-and-outs-of-platelets-in-ra
#13
Isabel Andia
No abstract text is available yet for this article.
April 6, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360424/the-emerging-safety-profile-of-jak-inhibitors-in-rheumatic-disease
#14
Kevin L Winthrop
No abstract text is available yet for this article.
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360423/immunometabolism-in-systemic-lupus-erythematosus
#15
REVIEW
Laurence Morel
Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic autoantibodies directed against nucleoprotein complexes. Beyond the activation of autoreactive B cells, this process involves dysregulation in many other types of immune cells, including CD4(+) T cells, dendritic cells, macrophages and neutrophils. Metabolic substrate utilization and integration of cues from energy sensors are critical checkpoints of effector functions in the immune system, with common as well as cell-specific programmes...
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28360422/immunometabolism-in-early-and-late-stages-of-rheumatoid-arthritis
#16
REVIEW
Cornelia M Weyand, Jörg J Goronzy
One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to proliferate, a property shared with the joint-resident cells that form the synovial pannus. The building of biomass imposes high demands for energy and biosynthetic precursors, implicating metabolic control as a basic disease mechanism. During preclinical RA, when autoreactive T cells expand and immunological tolerance is broken, the main sites of disease are the secondary lymphoid tissues. Naive CD4(+) T cells from patients with RA have a distinct metabolic signature, characterized by dampened glycolysis, low ATP levels and enhanced shunting of glucose into the pentose phosphate pathway...
March 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28331210/infection-therapeutics-and-risk-of-infection-in-pregnancy
#17
Jessica McHugh
No abstract text is available yet for this article.
March 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28331209/systemic-lupus-erythematosus-defective-cd11b-raises-ifn-levels-in-sle
#18
Joanna Collison
No abstract text is available yet for this article.
March 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28331207/osteroarthritis-a-new-tool-for-measuring-synovial-inflammation
#19
Jessica McHugh
No abstract text is available yet for this article.
March 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28331206/risk-factors-generational-differences-in-arthritis-prevalence
#20
Jessica McHugh
No abstract text is available yet for this article.
March 23, 2017: Nature Reviews. Rheumatology
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