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Nature Reviews. Rheumatology

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https://www.readbyqxmd.com/read/30242247/nanoparticles-in-neutrophil-clothing
#1
Joanna Collison
No abstract text is available yet for this article.
September 21, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30218025/mechanisms-biomarkers-and-targets-for-adult-onset-still-s-disease
#2
REVIEW
Eugen Feist, St├ęphane Mitrovic, Bruno Fautrel
Adult-onset Still's disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with potentially severe inflammatory onset accompanied by a broad spectrum of disease manifestation and complications, AoSD is an unsolved challenge for clinicians with limited therapeutic options. This Review provides a comprehensive insight into the complex and heterogeneous nature of AoSD, describing biomarkers of the disease and its progression and the cytokine signalling pathways that contribute to disease...
September 14, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30209413/modern-day-environmental-factors-in-the-pathogenesis-of-osteoarthritis
#3
REVIEW
Francis Berenbaum, Ian J Wallace, Daniel E Lieberman, David T Felson
The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which is a disease more common today than in the past because genes inherited from previous generations are inadequately or imperfectly adapted to modern environmental conditions. We focus on four major environmental factors in OA pathogenesis that have become ubiquitous within the past half-century: obesity, metabolic syndrome, dietary changes and physical inactivity...
September 12, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30209412/distinguishing-net-subtypes
#4
Jessica McHugh
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30209411/new-advice-to-give-patients-a-helping-hand
#5
Nicholas J Bernard
No abstract text is available yet for this article.
September 12, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30206374/cell-specific-epigenetic-modulation
#6
Jessica McHugh
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30206373/author-correction-treatment-in-myositis
#7
Chester V Oddis, Rohit Aggarwal
In the originally published version of this article, several references in Table 1 were incorrect. These errors have now been corrected in the HTML and PDF versions of the manuscript.
September 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30194361/csf1-drives-pain-in-arthritis
#8
Joanna Collison
No abstract text is available yet for this article.
September 7, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30190520/calcium-crystal-deposition-diseases-beyond-gout
#9
REVIEW
Geraldine M McCarthy, Aisling Dunne
The most common types of calcium-containing crystals that are associated with joint and periarticular disorders are calcium pyrophosphate dihydrate (CPP) and basic calcium phosphate (BCP) crystals. Several diverse but difficult-to-treat acute and chronic arthropathies and other clinical syndromes are associated with the deposition of these crystals. Although the pathogenic mechanism of calcium crystal deposition is partially understood, much remains to be investigated, as no drug is available to prevent crystal deposition, permit crystal dissolution or specifically target the pathogenic effects that result in the clinical manifestations...
September 6, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30185988/a-notch-in-the-joint-that-exacerbates-osteoarthritis
#10
Silvia Monteagudo, Rik J Lories
No abstract text is available yet for this article.
September 5, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30181583/targeting-the-tlr4-md2-axis-in-systemic-sclerosis
#11
Steven O'Reilly, Jacob M van Laar
No abstract text is available yet for this article.
September 4, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30181582/unravelling-how-glucocorticoids-work-in-rheumatoid-arthritis
#12
Rowan Hardy, Mark S Cooper
No abstract text is available yet for this article.
September 4, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30177734/a-fibrosis-checkpoint
#13
Nicholas J Bernard
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30177733/serum-biomarkers-for-diagnosing-pah
#14
Joanna Collison
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30177732/fat-mass-but-not-muscle-mass-linked-to-oa-risk
#15
Joanna Collison
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30177731/anti-tnf-therapy-not-linked-to-cancer-recurrence
#16
Joanna Collison
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30177730/intensive-therapy-is-beneficial-in-early-arthritis
#17
Joanna Collison
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30171203/rheumatic-immune-related-adverse-events-from-cancer-immunotherapy
#18
REVIEW
Leonard H Calabrese, Cassandra Calabrese, Laura C Cappelli
Immunotherapy has revolutionized the treatment of cancer, but a rapid rise in the use of the family of therapeutic agents known as checkpoint inhibitors (CPIs) is associated with a new group of immune-related adverse events (irAEs) in almost any organ system. Among these irAEs, rheumatic complications are common and seem to have features that are distinct from irAEs in other organ systems, including a highly variable time of clinical onset and the capacity to persist, possibly indefinitely, even after cessation of CPI therapy...
August 31, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30143752/primary-immunodeficiency-reveals-importance-of-ripk1
#19
Jessica McHugh
No abstract text is available yet for this article.
August 24, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/30108367/b-cell-therapy-in-anca-associated-vasculitis-current-and-emerging-treatment-options
#20
REVIEW
Mark McClure, Seerapani Gopaluni, David Jayne, Rachel Jones
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an organ-threatening and life-threatening multi-system autoimmune disease in which B cell-derived ANCAs cause neutrophil activation and endothelial damage, strongly implicating these autoantibodies in the pathogenesis of AAV. B cell depletion with rituximab combined with glucocorticoids is associated with a reduction in ANCA concentrations and with clinical remission in the majority of patients with AAV. However, the safety profile of rituximab is no better than that of conventional therapy with cyclophosphamide, and long-term glucocorticoid treatment is needed to achieve and maintain disease-free remission...
August 14, 2018: Nature Reviews. Rheumatology
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