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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28513633/nafld-a-gut-microbiome-signature-for-advanced-fibrosis-diagnosis-in-nafld
#1
Hugh Thomas
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513632/how-to-stomach-an-epigenetic-insult-the-gastric-cancer-epigenome
#2
REVIEW
Nisha Padmanabhan, Toshikazu Ushijima, Patrick Tan
Gastric cancer is a deadly malignancy afflicting close to a million people worldwide. Patient survival is poor and largely due to late diagnosis and suboptimal therapies. Disease heterogeneity is a substantial obstacle, underscoring the need for precision treatment strategies. Studies have identified different subgroups of gastric cancer displaying not just genetic, but also distinct epigenetic hallmarks. Accumulating evidence suggests that epigenetic abnormalities in gastric cancer are not mere bystander events, but rather promote carcinogenesis through active mechanisms...
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513631/paediatrics-are-human-milk-oligosaccharides-the-magic-bullet-for-necrotizing-enterocolitis
#3
Michael S Caplan
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513630/ibd-tofacitinib-effective-in-ulcerative-colitis
#4
Conor A Bradley
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513629/post-infectious-ibs-tropical-sprue-and-small-intestinal-bacterial-overgrowth-the-missing-link
#5
REVIEW
Uday C Ghoshal, Kok-Ann Gwee
Evidence is emerging that IBS, a hitherto enigmatic disorder thought to be predominantly related to psychological factors, has a microorganic basis in a subset of patients with the disease. Post-infectious IBS (PI-IBS), commonly of the diarrhoea-predominant subtype (defined as new development of IBS following acute infectious diarrhoea), is one such condition known to occur in up to 10-30% individuals after acute gastroenteritis. However, following acute infectious gastroenteritis, patients can also develop post-infectious malabsorption syndrome (PI-MAS), popularly known as tropical sprue...
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487550/liver-cancer-nivolumab-checkmate-for-hepatocellular-carcinoma
#6
Katrina Ray
No abstract text is available yet for this article.
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487549/liver-deciphering-the-role-of-ifn%C3%AE-subclasses-in-hepatic-inflammation-and-fibrosis
#7
Katrina Ray
No abstract text is available yet for this article.
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487548/hepatitis-a-step-closer-to-easy-point-of-care-testing-for-hcv
#8
Katrina Ray
No abstract text is available yet for this article.
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487547/non-conventional-features-of-peripheral-serotonin-signalling-the-gut-and-beyond
#9
REVIEW
Stephanie N Spohn, Gary M Mawe
Serotonin was first discovered in the gut, and its conventional actions as an intercellular signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are a number of serotonin signalling pharmacotherapeutic targets for treatment of nausea, diarrhoea or constipation. The latest discoveries have greatly broadened our understanding of non-conventional actions of peripheral serotonin within the gastrointestinal tract and in a number of other tissues. For example, it is now clear that bacteria within the lumen of the bowel influence serotonin synthesis and release by enterochromaffin cells...
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487546/gut-microbiota-tooling-up-for-microbiota-research
#10
Hugh Thomas
No abstract text is available yet for this article.
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28487545/mechanisms-of-hepatic-stellate-cell-activation
#11
REVIEW
Takuma Tsuchida, Scott L Friedman
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic myofibroblasts - is now well established as a central driver of fibrosis in experimental and human liver injury. Yet, the continued discovery of novel pathways and mediators, including autophagy, endoplasmic reticulum stress, oxidative stress, retinol and cholesterol metabolism, epigenetics and receptor-mediated signals, reveals the complexity of HSC activation...
May 10, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28465549/pancreatic-cancer-between-rock-and-a-hard-place
#12
Iain Dickson
No abstract text is available yet for this article.
May 3, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28465548/helicobacter-pylori-infection-and-antibiotic-resistance-a-who-high-priority
#13
Bich N Dang, David Y Graham
No abstract text is available yet for this article.
May 3, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28465547/coeliac-disease-a-viral-trigger-of-food-insensitivity-and-coeliac-disease
#14
Katrina Ray
No abstract text is available yet for this article.
May 3, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28442783/from-aacr-2017
#15
Conor A Bradley
No abstract text is available yet for this article.
April 26, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28442782/gut-microbiota-at-the-intersection-of-everything
#16
Patrice D Cani
No abstract text is available yet for this article.
April 26, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28428637/surgery-metabolic-surgery-the-cutting-edge-of-diabetes-care
#17
Francesco Rubino, Spyros Panagiotopoulos
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28428636/stem-cells-two-sides-to-cancer-stem-cells-in-colorectal-cancer
#18
Katrina Ray
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28428635/sepsis-bile-acids-promote-inflammation-in-cholestasis-associated-sepsis
#19
Hugh Thomas
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28428634/lipid-droplets-and-liver-disease-from-basic-biology-to-clinical-implications
#20
REVIEW
Nina L Gluchowski, Michel Becuwe, Tobias C Walther, Robert V Farese
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases, such as the metabolic syndrome or obesity, often result in abnormal lipid accumulation in lipid droplets in the liver, also called hepatic steatosis. Obesity-related steatosis, or NAFLD in particular, is a major public health concern worldwide and is frequently associated with insulin resistance and type 2 diabetes mellitus. Here, we review the latest insights into the biology of lipid droplets and their role in maintaining lipid homeostasis in the liver...
April 21, 2017: Nature Reviews. Gastroenterology & Hepatology
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