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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28634412/extracellular-vesicles-in-liver-disease-and-potential-as-biomarkers-and-therapeutic-targets
#1
REVIEW
Gyongyi Szabo, Fatemeh Momen-Heravi
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics...
June 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634411/stomach-a-chief-role-for-lgr5-cells
#2
Katrina Ray
No abstract text is available yet for this article.
June 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611482/infection-unlocking-the-crypto-drug-cabinet
#3
Katrina Ray
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611481/ibd-phase-ii-trial-success-for-anti-madcam1-antibody
#4
Iain Dickson
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611480/expert-consensus-document-the-international-scientific-association-for-probiotics-and-prebiotics-isapp-consensus-statement-on-the-definition-and-scope-of-prebiotics
#5
REVIEW
Glenn R Gibson, Robert Hutkins, Mary Ellen Sanders, Susan L Prescott, Raylene A Reimer, Seppo J Salminen, Karen Scott, Catherine Stanton, Kelly S Swanson, Patrice D Cani, Kristin Verbeke, Gregor Reid
In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food...
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611479/nafld-pnpla3-and-obesity-a-synergistic-relationship-in-nafld
#6
Jake P Mann, Quentin M Anstee
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611478/therapy-bacteriophages-important-for-fmt-efficacy
#7
Iain Dickson
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611477/a-guide-to-multimodal-endoscopy-imaging-for-gastrointestinal-malignancy-an-early-indicator
#8
REVIEW
Arthur Hoffman, Henrik Manner, Johannes W Rey, Ralf Kiesslich
Multimodality imaging is an essential aspect of endoscopic surveillance for the detection of neoplastic lesions, such as dysplasia or intramucosal cancer, because it improves the efficacy of endoscopic surveillance and therapeutic procedures in the gastrointestinal tract. This approach reveals mucosal abnormalities that cannot be detected by standard endoscopy. Currently, these imaging techniques are divided into those for primary detection and those for targeted imaging and characterization, the latter being used to visualize areas of interest in detail and permit histological evaluation...
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611476/primary-sclerosing-cholangitis-ursodeoxycholic-acid-derivative-safe-and-effective
#9
Iain Dickson
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28588264/neurogastroenterology-cell-lineage-relationships-dictate-ens-organization
#10
Iain Dickson
No abstract text is available yet for this article.
June 7, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28588263/gut-microbiota-intestinal-fungi-fuel-the-inflammatory-fire-in-alcoholic-liver-disease
#11
Hugh Thomas
No abstract text is available yet for this article.
June 7, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28559592/gut-microbiota-inulin-regulates-endothelial-function-a-prebiotic-smoking-gun
#12
Francesca Fava, Kieran M Tuohy
No abstract text is available yet for this article.
May 31, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28559591/genetics-novel-causative-genes-for-polycystic-liver-disease
#13
María J Perugorria, Jesús M Banales
No abstract text is available yet for this article.
May 31, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28559590/gut-microbiota-trust-your-gut-metformin-and-diabetes
#14
Conor A Bradley
No abstract text is available yet for this article.
May 31, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28536485/management-of-refractory-eosinophilic-oesophagitis
#15
REVIEW
Evan S Dellon
The goal of this Review is to discuss the clinical approach to patients who do not respond to treatment for eosinophilic oesophagitis (EoE). Refractory EoE is challenging to manage as there are limited data to guide decision-making. In this Review, refractory EoE is defined as persistent eosinophilia in the setting of incomplete resolution of the primary presenting symptoms and incomplete resolution of endoscopic findings following a PPI trial, and after treatment with either topical steroids or dietary elimination...
May 24, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28536484/ibs-mindful-of-probiotics-for-psychiatric-comorbidities-in-ibs
#16
Katrina Ray
No abstract text is available yet for this article.
May 24, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513633/nafld-a-gut-microbiome-signature-for-advanced-fibrosis-diagnosis-in-nafld
#17
Hugh Thomas
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513632/how-to-stomach-an-epigenetic-insult-the-gastric-cancer-epigenome
#18
REVIEW
Nisha Padmanabhan, Toshikazu Ushijima, Patrick Tan
Gastric cancer is a deadly malignancy afflicting close to a million people worldwide. Patient survival is poor and largely due to late diagnosis and suboptimal therapies. Disease heterogeneity is a substantial obstacle, underscoring the need for precision treatment strategies. Studies have identified different subgroups of gastric cancer displaying not just genetic, but also distinct epigenetic hallmarks. Accumulating evidence suggests that epigenetic abnormalities in gastric cancer are not mere bystander events, but rather promote carcinogenesis through active mechanisms...
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513631/paediatrics-are-human-milk-oligosaccharides-the-magic-bullet-for-necrotizing-enterocolitis
#19
Michael S Caplan
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513630/ibd-tofacitinib-effective-in-ulcerative-colitis
#20
Conor A Bradley
No abstract text is available yet for this article.
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
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