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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28223701/nafld-a-critical-role-for-the-nlrp3-inflammasome-in-nash
#1
Hugh Thomas
No abstract text is available yet for this article.
February 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28223700/pancreatic-cancer-tumour-derived-evs-for-diagnosis
#2
Katrina Ray
No abstract text is available yet for this article.
February 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28196987/living-donor-liver-transplantation-eliminating-the-wait-for-death-in-end-stage-liver-disease
#3
REVIEW
Robert A Fisher
Adult-to-adult living donor liver transplantation (A2ALDLT), outside of Asia, remains an important yet underutilized gift of life. For patients with end-stage liver disease, A2ALDLT is a proven transplantation option, with lower waiting list mortality and suffering, and equivalent or better allograft and patient survival than deceased-donor liver transplantation (DDLT). The risks to living donors and the benefit to their recipients have been carefully defined with long-term level 1 and 2 evidence-based study...
February 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28196986/colorectal-cancer-a-new-innate-immune-sensor-functions-from-inside-the-colonic-epithelium
#4
Tianyan Gao, B Mark Evers
No abstract text is available yet for this article.
February 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28174420/clonal-evolution-of-colorectal-cancer-in-ibd
#5
REVIEW
Chang-Ho R Choi, Ibrahim Al Bakir, Ailsa L Hart, Trevor A Graham
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wounding and repair that are characteristic of the condition. Here, we review the biological drivers of mutant clone selection in IBD with particular reference to the unique histological architecture of the intestinal epithelium coupled with the inflammatory microenvironment in IBD, and the unique mutation patterns seen in IBD-driven neoplasia when compared with sporadic adenomas and CRC...
February 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28144028/current-and-emerging-therapeutic-targets-for-ibd
#6
REVIEW
Markus F Neurath
Various therapeutic advances have led to a paradigm shift in the clinical management of patients with IBD. The introduction of immunosuppressive (such as azathioprine) and biologic agents (such as TNF blockers) has markedly reduced the need to use corticosteroids for therapy. Furthermore, the α4β7 integrin blocker vedolizumab has been introduced for clinical IBD therapy. Moreover, various new inhibitors of cytokines (for example, IL-6-IL-6R and IL-12-IL-23 blockers or apremilast), modulators of cytokine signalling events (for example, JAK inhibitors or SMAD7 blocker), inhibitors of transcription factors (for example, GATA3 or RORγt) and new anti-adhesion and anti-T-cell-activation and migration strategies (for example, β7 integrin, sphingosine 1-phosphate receptors and MAdCAM1 inhibitors, regulatory T-cell therapy and stem cells) are currently being evaluated in controlled clinical trials...
February 1, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096540/alcoholic-liver-disease-alcoholic-hepatitis-a-warning-for-prednisolone-and-infection-risk
#7
Katrina Ray
No abstract text is available yet for this article.
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096539/development-modelling-human-stomach-development-with-gastric-organoids
#8
Katrina Ray
No abstract text is available yet for this article.
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096538/pancreatic-cancer-pancreatic-tumours-derive-amino-acids-via-extracellular-protein-uptake
#9
Hugh Thomas
No abstract text is available yet for this article.
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28074075/primary-biliary-cholangitis-in-2016-high-definition-pbc-biology-models-and-therapeutic-advances
#10
Gwilym J Webb, Gideon M Hirschfield
No abstract text is available yet for this article.
January 11, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28074074/ibd-in-2016-biologicals-and-biosimilars-in-ibd-the-road-to-personalized-treatment
#11
Krisztina B Gecse, Péter L Lakatos
No abstract text is available yet for this article.
January 11, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053342/liver-transplantation-for-hepatocellular-carcinoma-outcomes-and-novel-surgical-approaches
#12
REVIEW
Gonzalo Sapisochin, Jordi Bruix
Liver transplantation for hepatocellular carcinoma (HCC) is the best treatment option for patients with early-stage tumours and accounts for ∼20-40% of all liver transplantations performed at most centres worldwide. The Milan criteria are the most common criteria to select patients with HCC for transplantation but they can be seen as too restrictive. Several proposals have been made for a moderate expansion of the criteria, which result in good outcomes but with an increase in the risk of tumour recurrence...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053341/gut-brain-axis-in-2016-brain-gut-microbiota-axis-mood-metabolism-and-behaviour
#13
Timothy G Dinan, John F Cryan
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#14
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28053337/hbv-in-2016-global-and-immunotherapeutic-insights-into-hepatitis-b
#15
Mala K Maini, Antonio Bertoletti
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27999436/food-allergy-and-the-gut
#16
REVIEW
Anna Nowak-Wegrzyn, Hania Szajewska, Gideon Lack
Food allergy develops as a consequence of a failure in oral tolerance, which is a default immune response by the gut-associated lymphoid tissues to ingested antigens that is modified by the gut microbiota. Food allergy is classified on the basis of the involvement of IgE antibodies in allergic pathophysiology, either as classic IgE, mixed pathophysiology or non-IgE-mediated food allergy. Gastrointestinal manifestations of food allergy include emesis, nausea, diarrhoea, abdominal pain, dysphagia, food impaction, protein-losing enteropathy and failure to thrive...
December 21, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27999435/gut-microbiota-intestinal-microbiota-oscillations-regulate-host-circadian-physiology
#17
Iain Dickson
No abstract text is available yet for this article.
December 21, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27924080/global-epidemiology-and-burden-of-hcv-infection-and-hcv-related-disease
#18
REVIEW
Aaron P Thrift, Hashem B El-Serag, Fasiha Kanwal
Chronic HCV infection is a global health problem that affects >184 million people worldwide. HCV is associated with several hepatic and extrahepatic disorders, including several malignancies. The burden of HCV-related disorders is influenced by the number of new and existing cases, number of existing cases and the natural history of the infection. The natural history of HCV is affected by several demographic, virological, clinical and lifestyle factors. Major variations exist in the burden of HCV among different populations and geographical regions, as well as over time...
December 7, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28196985/liver-spatial-division-of-hepatic-metabolic-labour
#19
Conor A Bradley
No abstract text is available yet for this article.
March 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28174419/infection-modifying-recurrence-of-clostridium-difficile-infection
#20
Katrina Ray
No abstract text is available yet for this article.
March 2017: Nature Reviews. Gastroenterology & Hepatology
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