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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28930295/global-burden-of-nafld-and-nash-trends-predictions-risk-factors-and-prevention
#1
REVIEW
Zobair Younossi, Quentin M Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi
NAFLD is one of the most important causes of liver disease worldwide and will probably emerge as the leading cause of end-stage liver disease in the coming decades, with the disease affecting both adults and children. The epidemiology and demographic characteristics of NAFLD vary worldwide, usually parallel to the prevalence of obesity, but a substantial proportion of patients are lean. The large number of patients with NAFLD with potential for progressive liver disease creates challenges for screening, as the diagnosis of NASH necessitates invasive liver biopsy...
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28930294/surgery-kras-mutations-and-hepatic-recurrence-after-treatment-of-colorectal-liver-metastases
#2
Kristoffer Watten Brudvik, Jean-Nicolas Vauthey
No abstract text is available yet for this article.
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28930293/colorectal-cancer-what-is-the-role-of-lymph-node-metastases-in-the-progression-of-colorectal-cancer
#3
Iris D Nagtegaal, Hans-Joachim Schmoll
No abstract text is available yet for this article.
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28930292/proton-pump-inhibitors-understanding-the-complications-and-risks
#4
REVIEW
Peter Malfertheiner, Arne Kandulski, Marino Venerito
Proton-pump inhibitors (PPIs) are the most effective therapy for the full spectrum of gastric-acid-related diseases. However, in the past decade, a steadily increasing list of complications following long-term use of PPIs has been reported. Their potent acid-suppressive action induces several structural and functional changes within the gastric mucosa, including fundic gland polyps, enterochromaffin-like cell hyperplasia and hypergastrinaemia, which can be exaggerated in the presence of Helicobacter pylori infection...
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28930291/ibd-key-genetic-regulators-of-ibd-identified-by-genomic-network-modelling
#5
Hugh Thomas
No abstract text is available yet for this article.
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28930290/alcohol-adipose-tissue-and-liver-disease-mechanistic-links-and-clinical-considerations
#6
REVIEW
Richard Parker, Seung-Jin Kim, Bin Gao
Adipose tissue represents a large volume of biologically active tissue that exerts substantial systemic effects in health and disease. Alcohol consumption can profoundly disturb the normal functions of adipose tissue by inducing adipocyte death and altering secretion of adipokines, pro-inflammatory mediators and free fatty acids from adipose tissue, which have important direct and indirect effects on the pathogenesis of alcoholic liver disease (ALD). Cessation of alcohol intake quickly reverses inflammatory changes in adipose tissue, and pharmacological treatment that normalizes adipose tissue function improves experimental ALD...
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28900240/gut-microbiota-microbial-metabolites-as-mimickers-of-human-molecules
#7
Katrina Ray
No abstract text is available yet for this article.
September 13, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28874836/oesophagus-symptom-perception-in-patients-with-nerd-do-nerves-matter
#8
Edoardo Savarino, Marco Della Coletta
No abstract text is available yet for this article.
September 6, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28874835/pancreatic-cancer-exosomes-for-targeting-kras-in-the-treatment-of-pancreatic-cancer
#9
Louis Buscail
No abstract text is available yet for this article.
September 6, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28874834/immunology-lcms-and-the-liver-additional-surveillance
#10
Katrina Ray
No abstract text is available yet for this article.
September 6, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28874833/stem-cells-r-spondin-3-is-a-critical-regulator-of-gastric-antral-stem-cell-homeostasis
#11
Hugh Thomas
No abstract text is available yet for this article.
September 6, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28853446/intestinal-hypoxia-and-hypoxia-induced-signalling-as-therapeutic-targets-for-ibd
#12
REVIEW
Sophie Van Welden, Andrew C Selfridge, Pieter Hindryckx
Tissue hypoxia occurs when local oxygen demand exceeds oxygen supply. In chronic inflammatory conditions such as IBD, the increased oxygen demand by resident and gut-infiltrating immune cells coupled with vascular dysfunction brings about a marked reduction in mucosal oxygen concentrations. To counter the hypoxic challenge and ensure their survival, mucosal cells induce adaptive responses, including the activation of hypoxia-inducible factors (HIFs) and modulation of nuclear factor-κB (NF-κB). Both pathways are tightly regulated by oxygen-sensitive prolyl hydroxylases (PHDs), which therefore represent promising therapeutic targets for IBD...
August 30, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831187/coeliac-disease-blood-test-for-diagnosis-more-effective-than-biopsy
#13
Iain Dickson
No abstract text is available yet for this article.
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831186/the-ibd-interactome-an-integrated-view-of-aetiology-pathogenesis-and-therapy
#14
REVIEW
Heitor S P de Souza, Claudio Fiocchi, Dimitrios Iliopoulos
Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by chronic and heterogeneous manifestations, induced by interacting environmental, genomic, microbial and immunological factors. These interactions result in an overwhelming complexity that cannot be tackled by studying the totality of each pathological component (an '-ome') in isolation without consideration of the interaction among all relevant -omes that yield an overall 'network effect'. The outcome of this effect is the 'IBD interactome', defined as a disease network in which dysregulation of individual -omes causes intestinal inflammation mediated by dysfunctional molecular modules...
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831185/innate-immunity-a-new-way-out-for-lysozyme
#15
Shimona Starling
No abstract text is available yet for this article.
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831184/direct-acting-antiviral-agents-for-hcv-infection-affecting-people-who-inject-drugs
#16
REVIEW
Jason Grebely, Behzad Hajarizadeh, Gregory J Dore
Globally, 12 million people are estimated to have injected drugs in the past year, 50% of whom have chronic HCV infection, with people who have previously injected drugs presenting an additional large reservoir of infection. The availability of simple and tolerable interferon-free direct-acting antiviral agents (DAAs) for HCV infection, which have a cure rate of >95% represents one of the most exciting advances in clinical medicine in the past few decades. Adherence and response to DAA therapy among people who inject drugs (PWID) receiving opioid substitution therapy (OST) in clinical trials are comparable to populations without a history of injecting drugs...
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831183/lower-gastrointestinal-tract-what-are-normal-bowel-movement-patterns
#17
Iain Dickson
No abstract text is available yet for this article.
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28831182/colorectal-cancer-early-mri-imaging-predicts-regorafenib-response
#18
Iain Dickson
No abstract text is available yet for this article.
August 23, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28811675/biomarkers-matching-mutations-to-immunotherapy-response
#19
Katrina Ray
No abstract text is available yet for this article.
August 16, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28811674/regenerative-medicine-and-cell-based-approaches-to-restore-pancreatic-function
#20
REVIEW
Cara Ellis, Adam Ramzy, Timothy J Kieffer
The pancreas is a complex organ with exocrine and endocrine components. Many pathologies impair exocrine function, including chronic pancreatitis, cystic fibrosis and pancreatic ductal adenocarcinoma. Conversely, when the endocrine pancreas fails to secrete sufficient insulin, patients develop diabetes mellitus. Pathology in either the endocrine or exocrine pancreas results in devastating economic and personal consequences. The current standard therapy for treating patients with type 1 diabetes mellitus is daily exogenous insulin injections, but cell sources of insulin provide superior glycaemic regulation and research is now focused on the goal of regenerating or replacing β cells...
August 16, 2017: Nature Reviews. Gastroenterology & Hepatology
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