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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28325929/gut-microbiota-neonatal-gut-microbiota-induces-lung-immunity-against-pneumonia
#1
Sabrina Tamburini, Jose C Clemente
No abstract text is available yet for this article.
March 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293029/liver-pet-for-bile-transport-kinetics
#2
Iain Dickson
No abstract text is available yet for this article.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293028/hepatitis-microrna-antagonists-promising-antiviral-agents-against-hcv-and-other-viruses
#3
Jean-Michel Pawlotsky
No abstract text is available yet for this article.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293027/genetics-of-primary-sclerosing-cholangitis-and-pathophysiological-implications
#4
REVIEW
Xiaojun Jiang, Tom H Karlsen
Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via the development of cholestatic liver cirrhosis, concurrent IBD and a high risk of bile duct cancer. Expectations have been high that genetic studies would determine key factors in PSC pathogenesis to support the development of effective medical therapies. Through the application of genome-wide association studies, a large number of disease susceptibility genes have been identified...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293026/therapy-the-role-of-liquid-biopsies-to-manage-and-predict-prrt-for-nets
#5
Mark Kidd, Irvin M Modlin
No abstract text is available yet for this article.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293025/experimental-model-modelling-immune-microbe-interaction-in-3d-intestinal-culture
#6
Hugh Thomas
No abstract text is available yet for this article.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293024/what-s-unique-about-acute-pancreatitis-in-children-risk-factors-diagnosis-and-management
#7
REVIEW
Sohail Z Husain, Arvind I Srinath
Pancreatitis in children is an appreciable problem that has become increasingly prevalent. This Review covers the principles related to the definitions, epidemiology, risk factors, diagnosis and management of acute pancreatitis in children and identifies features that are unique among children. Additionally, knowledge gaps related to management principles are identified.
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28293023/advances-in-image-enhancement-in-colonoscopy-for-detection-of-adenomas
#8
REVIEW
Takahisa Matsuda, Akiko Ono, Masau Sekiguchi, Takahiro Fujii, Yutaka Saito
High-quality colonoscopy is mandatory to prevent adenoma recurrence and colorectal cancer. In the past few years, technical advances have been developed with the purpose of improving adenoma detection rate (ADR), one of the most important validated colonoscopy quality benchmarks. Several techniques or devices are used to optimize visualization: observation techniques; add-on devices; auxiliary imaging devices; colonoscopes with increased field of view; and colonoscopes with an integrated inflatable reusable balloon...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28270698/gut-microbiota-modulation-of-chemotherapy-efficacy-and-toxicity
#9
REVIEW
James L Alexander, Ian D Wilson, Julian Teare, Julian R Marchesi, Jeremy K Nicholson, James M Kinross
Evidence is growing that the gut microbiota modulates the host response to chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; abrogation and compromise of anticancer effects; and mediation of toxicity. The implication is that gut microbiota are critical to the development of personalized cancer treatment strategies and, therefore, a greater insight into prokaryotic co-metabolism of chemotherapeutic drugs is now required. This thinking is based on evidence from human, animal and in vitro studies that gut bacteria are intimately linked to the pharmacological effects of chemotherapies (5-fluorouracil, cyclophosphamide, irinotecan, oxaliplatin, gemcitabine, methotrexate) and novel targeted immunotherapies such as anti-PD-L1 and anti-CLTA-4 therapies...
March 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28270697/liver-taking-out-the-junk-to-treat-%C3%AE-1-antitrypsin-deficiency
#10
S Tamir Rashid, David A Lomas
No abstract text is available yet for this article.
March 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28270696/ibd-genetic-differences-in-crohn-s-disease-susceptibility-and-outcome
#11
Kajari Mondal, Subra Kugathasan
No abstract text is available yet for this article.
March 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28270695/neurogastroenterology-a-shift-in-macrophage-phenotype-underlies-age-related-ens-degeneration
#12
Katrina Ray
No abstract text is available yet for this article.
March 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28270694/acinar-cell-plasticity-and-development-of-pancreatic-ductal-adenocarcinoma
#13
REVIEW
Peter Storz
Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal metaplasia (ADM), is an important feature facilitating pancreas regeneration after injury. Data from animal models show that cells that undergo ADM in response to oncogenic signalling are precursors for pancreatic intraepithelial neoplasia lesions, which can further progress to pancreatic ductal adenocarcinoma (PDAC). As human pancreatic adenocarcinoma is often diagnosed at a stage of metastatic disease, understanding the processes that lead to its initiation is important for the discovery of markers for early detection, as well as options that enable an early intervention...
March 8, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28250470/ibd-fmt-induces-clinical-remission-in-ulcerative-colitis
#14
Hugh Thomas
No abstract text is available yet for this article.
March 1, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28250469/gut-microbiota-diagnosing-ibd-with-the-gut-microbiome
#15
Iain Dickson
No abstract text is available yet for this article.
March 1, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28223701/nafld-a-critical-role-for-the-nlrp3-inflammasome-in-nash
#16
Hugh Thomas
No abstract text is available yet for this article.
February 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28223700/pancreatic-cancer-tumour-derived-evs-for-diagnosis
#17
Katrina Ray
No abstract text is available yet for this article.
February 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28196987/living-donor-liver-transplantation-eliminating-the-wait-for-death-in-end-stage-liver-disease
#18
REVIEW
Robert A Fisher
Adult-to-adult living donor liver transplantation (A2ALDLT), outside of Asia, remains an important yet underutilized gift of life. For patients with end-stage liver disease, A2ALDLT is a proven transplantation option, with lower waiting list mortality and suffering, and equivalent or better allograft and patient survival than deceased-donor liver transplantation (DDLT). The risks to living donors and the benefit to their recipients have been carefully defined with long-term level 1 and 2 evidence-based study...
February 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28196986/colorectal-cancer-a-new-innate-immune-sensor-functions-from-inside-the-colonic-epithelium
#19
Tianyan Gao, B Mark Evers
No abstract text is available yet for this article.
February 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28174420/clonal-evolution-of-colorectal-cancer-in-ibd
#20
REVIEW
Chang-Ho R Choi, Ibrahim Al Bakir, Ailsa L Hart, Trevor A Graham
Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wounding and repair that are characteristic of the condition. Here, we review the biological drivers of mutant clone selection in IBD with particular reference to the unique histological architecture of the intestinal epithelium coupled with the inflammatory microenvironment in IBD, and the unique mutation patterns seen in IBD-driven neoplasia when compared with sporadic adenomas and CRC...
February 8, 2017: Nature Reviews. Gastroenterology & Hepatology
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