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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/28698664/regenerative-medicine-bioengineering-the-common-bile-duct
#1
Hugh Thomas
No abstract text is available yet for this article.
July 12, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28698663/medical-devices-for-the-treatment-of-obesity
#2
REVIEW
Phong Ching Lee, John Dixon
Obesity is a major public health concern that leads to numerous metabolic, mechanical and psychological complications. Although lifestyle interventions are the cornerstone of obesity management, subsequent physiological neurohormonal adaptations limit weight loss, strongly favour weight regain and counteract sustained weight loss. A range of effective therapies are therefore needed to manage this chronic relapsing disease. Bariatric surgery delivers substantial, durable weight loss but limited access to care, perceived high risks and costs restrict uptake...
July 12, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28698662/the-extracellular-matrix-of-the-gastrointestinal-tract-a-regenerative-medicine-platform
#3
REVIEW
George S Hussey, Timothy J Keane, Stephen F Badylak
The synthesis and secretion of components that constitute the extracellular matrix (ECM) by resident cell types occur at the earliest stages of embryonic development, and continue throughout life in both healthy and diseased physiological states. The ECM consists of a complex mixture of insoluble and soluble functional components that are arranged in a tissue-specific 3D ultrastructure, and it regulates numerous biological processes, including angiogenesis, innervation and stem cell differentiation. Owing to its composition and influence on embryonic development, as well as cellular and organ homeostasis, the ECM is an ideal therapeutic substrate for the repair of damaged or diseased tissues...
July 12, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676712/nafld-increased-familial-risk-of-fibrosis-in-nafld
#4
Iain Dickson
No abstract text is available yet for this article.
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676711/rotavirus-inflammasome-modulates-rotavirus-infection
#5
Iain Dickson
No abstract text is available yet for this article.
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676710/neurogastroenterology-tasting-the-gut-enterochromaffin-cells-are-chemosensitive-and-modulate-sensory-neurons
#6
Hugh Thomas
No abstract text is available yet for this article.
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676709/rectal-cancer-no-benefit-for-local-excision-over-rectal-excision
#7
Iain Dickson
No abstract text is available yet for this article.
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676708/ibd-to-switch-or-not-to-switch-that-is-the-biosimilar-question
#8
Silvio Danese, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676707/the-gut-microbiome-and-liver-cancer-mechanisms-and-clinical-translation
#9
REVIEW
Le-Xing Yu, Robert F Schwabe
Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality. HCC almost exclusively develops in patients with chronic liver disease, driven by a vicious cycle of liver injury, inflammation and regeneration that typically spans decades. Increasing evidence points towards a key role of the bacterial microbiome in promoting the progression of liver disease and the development of HCC. Here, we will review mechanisms by which the gut microbiota promotes hepatocarcinogenesis, focusing on the leaky gut, bacterial dysbiosis, microbe-associated molecular patterns and bacterial metabolites as key pathways that drive cancer-promoting liver inflammation, fibrosis and genotoxicity...
July 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28655884/intestinal-lymphatic-vasculature-structure-mechanisms-and-functions
#10
REVIEW
Jeremiah Bernier-Latmani, Tatiana V Petrova
The mammalian intestine is richly supplied with lymphatic vasculature, which has functions ranging from maintenance of interstitial fluid balance to transport of antigens, antigen-presenting cells, dietary lipids and fat-soluble vitamins. In this Review, we provide in-depth information concerning the organization and structure of intestinal lymphatics, the current view of their developmental origins, as well as molecular mechanisms of intestinal lymphatic patterning and maintenance. We will also discuss physiological aspects of intestinal lymph flow regulation and the known and emerging roles of intestinal lymphatic vessels in human diseases, such as IBD, infection and cancer...
June 28, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28655880/neurogastroenterology-the-dynamic-cycle-of-life-in-the-enteric-nervous-system
#11
Meenakshi Rao, Michael D Gershon
No abstract text is available yet for this article.
June 28, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28655879/viral-hepatitis-charting-hcv-genotype-2-1-recombinant-strains
#12
Katrina Ray
No abstract text is available yet for this article.
June 28, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28655878/nafld-thermoneutral-housing-of-mice-improves-modelling-of-nafld
#13
Iain Dickson
No abstract text is available yet for this article.
June 28, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634412/extracellular-vesicles-in-liver-disease-and-potential-as-biomarkers-and-therapeutic-targets
#14
REVIEW
Gyongyi Szabo, Fatemeh Momen-Heravi
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics...
June 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28634411/stomach-a-chief-role-for-lgr5-cells
#15
Katrina Ray
No abstract text is available yet for this article.
June 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611480/expert-consensus-document-the-international-scientific-association-for-probiotics-and-prebiotics-isapp-consensus-statement-on-the-definition-and-scope-of-prebiotics
#16
REVIEW
Glenn R Gibson, Robert Hutkins, Mary Ellen Sanders, Susan L Prescott, Raylene A Reimer, Seppo J Salminen, Karen Scott, Catherine Stanton, Kelly S Swanson, Patrice D Cani, Kristin Verbeke, Gregor Reid
In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food...
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611479/nafld-pnpla3-and-obesity-a-synergistic-relationship-in-nafld
#17
Jake P Mann, Quentin M Anstee
No abstract text is available yet for this article.
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28536485/management-of-refractory-eosinophilic-oesophagitis
#18
REVIEW
Evan S Dellon
The goal of this Review is to discuss the clinical approach to patients who do not respond to treatment for eosinophilic oesophagitis (EoE). Refractory EoE is challenging to manage as there are limited data to guide decision-making. In this Review, refractory EoE is defined as persistent eosinophilia in the setting of incomplete resolution of the primary presenting symptoms and incomplete resolution of endoscopic findings following a PPI trial, and after treatment with either topical steroids or dietary elimination...
May 24, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28513632/how-to-stomach-an-epigenetic-insult-the-gastric-cancer-epigenome
#19
REVIEW
Nisha Padmanabhan, Toshikazu Ushijima, Patrick Tan
Gastric cancer is a deadly malignancy afflicting close to a million people worldwide. Patient survival is poor and largely due to late diagnosis and suboptimal therapies. Disease heterogeneity is a substantial obstacle, underscoring the need for precision treatment strategies. Studies have identified different subgroups of gastric cancer displaying not just genetic, but also distinct epigenetic hallmarks. Accumulating evidence suggests that epigenetic abnormalities in gastric cancer are not mere bystander events, but rather promote carcinogenesis through active mechanisms...
May 17, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28442783/from-aacr-2017
#20
Conor A Bradley
No abstract text is available yet for this article.
April 26, 2017: Nature Reviews. Gastroenterology & Hepatology
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