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Nature Reviews. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/29777166/de-novo-hepatocyte-derived-biliary-system
#1
Iain Dickson
No abstract text is available yet for this article.
May 18, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29773899/management-of-acute-hcv-infection-in-the-era-of-direct-acting-antiviral-therapy
#2
REVIEW
Marianne Martinello, Behzad Hajarizadeh, Jason Grebely, Gregory J Dore, Gail V Matthews
The management of acute HCV infection has not been standardized following the availability of direct-acting antiviral agents (DAAs) for chronic HCV infection, and substantial uncertainty exists regarding the optimal treatment regimen and duration. Despite the lack of direct evidence, the 2016 American Association for the Study of Liver Diseases (AASLD)-Infectious Diseases Society of America (IDSA) guidelines supported "the same regimens for acute HCV as recommended for chronic HCV infection … owing to high efficacy and safety", whereas the 2016 European Association for the Study of the Liver (EASL) guidelines recommended sofosbuvir-ledipasvir, sofosbuvir-velpatasvir or sofosbuvir plus daclatasvir for 8 weeks in acute HCV infection, with a longer duration of 12 weeks recommended for those infected with HIV and/or baseline HCV RNA levels >1,000,000 IU/ml...
May 17, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29760502/infant-colic-mechanisms-and-management
#3
REVIEW
Judith Zeevenhooven, Pamela D Browne, Monique P L'Hoir, Carolina de Weerth, Marc A Benninga
Infant colic is a commonly reported phenomenon of excessive crying in infancy with an enigmatic and distressing character. Despite its frequent occurrence, little agreement has been reached on the definition, pathogenesis or the optimal management strategy for infant colic. This Review aims to delineate the definitional entanglement with the Rome IV criteria, which were published in 2016, as the leading, most recent diagnostic criteria. Moreover, neurogenic, gastrointestinal, microbial and psychosocial factors that might contribute to the pathophysiology of infant colic are explored...
May 14, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29752457/broad-collateral-damage-of-drugs-against-the-gut-microbiome
#4
Peter Spanogiannopoulos, Peter J Turnbaugh
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29752456/opportunities-of-twin-research-in-gastroenterology
#5
Miriam Goebel-Stengel, Gerald Holtmann, Paul Enck
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29752455/hcv-therapy-and-risk-of-liver-cancer-recurrence-who-to-treat
#6
Massimo Colombo, Vincenzo Boccaccio
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29748587/nafld-hcc-target-cholesterol
#7
Katrina Ray
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29748586/the-gut-liver-axis-and-the-intersection-with-the-microbiome
#8
REVIEW
Anupriya Tripathi, Justine Debelius, David A Brenner, Michael Karin, Rohit Loomba, Bernd Schnabl, Rob Knight
In the past decade, an exciting realization has been that diverse liver diseases - ranging from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular carcinoma - fall along a spectrum. Work on the biology of the gut-liver axis has assisted in understanding the basic biology of both alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD). Of immense importance is the advancement in understanding the role of the microbiome, driven by high-throughput DNA sequencing and improved computational techniques that enable the complexity of the microbiome to be interrogated, together with improved experimental designs...
May 10, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29740166/triggering-and-resolution-of-inflammation-in-nash
#9
REVIEW
Susanne Schuster, Daniel Cabrera, Marco Arrese, Ariel E Feldstein
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis. A central issue in this field relates to the identification of those factors that trigger inflammation, thus fuelling the transition from nonalcoholic fatty liver to NASH. These triggers of liver inflammation might have their origins outside the liver (such as in adipose tissue or the gut) as well as inside the organ (for instance, lipotoxicity, innate immune responses, cell death pathways, mitochondrial dysfunction and endoplasmic reticulum stress), both of which contribute to NASH development...
May 8, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29720709/tuft-cells-revealed-as-norovirus-target
#10
Hugh Thomas
No abstract text is available yet for this article.
May 2, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29717230/therapeutic-developments-in-pancreatic-cancer-current-and-future-perspectives
#11
REVIEW
John P Neoptolemos, Jörg Kleeff, Patrick Michl, Eithne Costello, William Greenhalf, Daniel H Palmer
The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading cause of cancer-related mortality in the next decade in Western countries. The past few years, however, have seen improvements in first-line and second-line palliative therapies and considerable progress in increasing survival with adjuvant treatment. The use of biomarkers to help define treatment and the potential of neoadjuvant therapies also offer opportunities to improve outcomes...
May 1, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29713024/gastric-cancer-evidence-boosts-helicobacter-pylori-eradication
#12
Hidekazu Suzuki, Juntaro Matsuzaki
No abstract text is available yet for this article.
April 30, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29713023/personalized-screening-for-colorectal-cancer
#13
Ernst J Kuipers, Manon C Spaander
No abstract text is available yet for this article.
April 30, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29713022/preserving-the-liver-for-transplantation
#14
Katrina Ray
No abstract text is available yet for this article.
April 30, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29713021/risk-of-cardiomyopathy-and-cardiac-arrhythmias-in-patients-with-nonalcoholic-fatty-liver-disease
#15
REVIEW
Quentin M Anstee, Alessandro Mantovani, Herbert Tilg, Giovanni Targher
Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects up to one-quarter of the adult population worldwide. The clinical and economic burden of NAFLD is mainly due to liver-related morbidity and mortality (nonalcoholic steatohepatitis, cirrhosis or hepatocellular carcinoma) and an increased risk of developing fatal and nonfatal cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers (for example, colorectal cancer and breast cancer). Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects...
April 30, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29703976/searching-for-superstool-maximizing-the-therapeutic-potential-of-fmt
#16
Scott W Olesen, McKenzie M Leier, Eric J Alm, Stacy A Kahn
No abstract text is available yet for this article.
April 27, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29686405/an-hsd17b13-variant-reduces-cirrhosis-risk
#17
Hugh Thomas
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29686404/systems-biology-in-hepatology-approaches-and-applications
#18
REVIEW
Adil Mardinoglu, Jan Boren, Ulf Smith, Mathias Uhlen, Jens Nielsen
Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner...
April 23, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29679065/gut-development-on-a-full-stomach
#19
Arthur Beyder
No abstract text is available yet for this article.
April 20, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29674642/microbiome-promotes-pancreatic-cancer
#20
Iain Dickson
No abstract text is available yet for this article.
April 19, 2018: Nature Reviews. Gastroenterology & Hepatology
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