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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/29148545/cardiovascular-endocrinology-long-term-safety-of-growth-hormone
#1
Conor A Bradley
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29148544/reproductive-endocrinology-exposure-to-pesticide-residues-linked-to-adverse-pregnancy-outcomes
#2
Alan Morris
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29125144/bone-high-intensity-exercise-to-prevent-fractures-risk-or-gain
#3
Wolfgang Kemmler, Simon von Stengel
No abstract text is available yet for this article.
November 10, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29125143/metabolism-metabolic-effects-of-intermeal-fasting
#4
Claire Greenhill
No abstract text is available yet for this article.
November 10, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29125142/bone-ppar%C3%AE-controls-marrow-adiposity
#5
Conor A Bradley
No abstract text is available yet for this article.
November 10, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29076504/the-special-relationship-glia-neuron-interactions-in-the-neuroendocrine-hypothalamus
#6
REVIEW
Jerome Clasadonte, Vincent Prevot
Natural fluctuations in physiological conditions require adaptive responses involving rapid and reversible structural and functional changes in the hypothalamic neuroendocrine circuits that control homeostasis. Here, we discuss the data that implicate hypothalamic glia in the control of hypothalamic neuroendocrine circuits, specifically neuron-glia interactions in the regulation of neurosecretion as well as neuronal excitability. Mechanistically, the morphological plasticity displayed by distal processes of astrocytes, pituicytes and tanycytes modifies the geometry and diffusion properties of the extracellular space...
October 27, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052591/targeting-thermogenesis-in-brown-fat-and-muscle-to-treat-obesity-and-metabolic-disease
#7
REVIEW
Matthias J Betz, Sven Enerbäck
Brown fat is emerging as an interesting and promising target for therapeutic intervention in obesity and metabolic disease. Activation of brown fat in humans is associated with marked improvement in metabolic parameters such as levels of free fatty acids and insulin sensitivity. Skeletal muscle is another important organ for thermogenesis, with the capacity to induce energy-consuming futile cycles. In this Review, we focus on how these two major thermogenic organs - brown fat and muscle - act and cooperate to maintain normal body temperature...
October 23, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052590/reversing-the-tide-diagnosis-and-prevention-of-t2dm-in-populations-of-african-descent
#8
REVIEW
Jean N Utumatwishima, Stephanie T Chung, Amy R Bentley, Margaret Udahogora, Anne E Sumner
Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis after preventable complications of the disease have occurred. Earlier detection would result in a reduction in undiagnosed T2DM, more accurate statistics, more informed resource allocation and better health. An underappreciated factor contributing to undiagnosed T2DM in populations of African descent is that screening tests for hyperglycaemia, specifically, fasting plasma glucose and HbA1c, perform sub-optimally in these populations...
October 23, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29027993/current-pharmacotherapy-for-obesity
#9
REVIEW
Gitanjali Srivastava, Caroline M Apovian
More than one-third of adults in the USA have obesity, which causes, exacerbates or adversely impacts numerous medical comorbidities, including diabetes mellitus and cardiovascular disease. Despite intensive lifestyle modifications, the disease severity warrants further aggressive intervention, including pharmacotherapy, medical devices and bariatric surgery. Noninvasive anti-obesity drugs have thus now resurfaced as targeted adjunctive therapeutic approaches to intensive lifestyle intervention, bridging the gap between lifestyle and bariatric surgery...
October 13, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885623/chronic-endocrine-consequences-of-traumatic-brain-injury-what-is-the-evidence
#10
REVIEW
Marianne Klose, Ulla Feldt-Rasmussen
Traumatic brain injury (TBI) is a major public health problem with potentially debilitating consequences for the individual. Hypopituitarism after TBI has received increasing attention over the past decade; development of the condition as a consequence of TBI was previously hardly mentioned in textbooks on the subject. Hypopituitarism has been reported in more than 25% of patients with TBI and is now thought to be one of the most important causes of treatable morbidity in TBI survivors. However, most clinicians dealing with neuroendocrine diseases and TBI generally do not see such a high incidence of hypopituitarism...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885621/primary-hyperparathyroidism
#11
REVIEW
Marcella D Walker, Shonni J Silverberg
In this Review, we describe the pathogenesis, diagnosis and management of primary hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a common endocrine disorder that is characterized by hypercalcaemia and elevated or inappropriately normal serum levels of parathyroid hormone. Most often, the presentation of PHPT is asymptomatic in regions of the world where serum levels of calcium are routinely measured. In addition to mild hypercalcaemia, PHPT can manifest with osteoporosis and hypercalciuria as well as with vertebral fractures and nephrolithiasis, both of which can be asymptomatic...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29076507/diabetes-omega-6-pufas-and-t2dm
#12
Conor A Bradley
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29076506/obesity-pharmacological-actions-of-fgf19-and-fgf21-revealed
#13
Alan Morris
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29076505/therapy-sglt-inhibition-in-t1dm-definite-benefit-with-manageable-risk
#14
Ele Ferrannini, Anna Solini
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052593/diabetes-predicting-severe-hypoglycaemia-a-step-forward
#15
Francesco Zaccardi, Kamlesh Khunti
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052592/genetics-towards-%C3%AE-cell-regeneration
#16
Claire Greenhill
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29052589/obesity-specialized-macrophages-contribute-to-obesity
#17
Conor A Bradley
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29027995/microbiota-fmt-transiently-improves-insulin-sensitivity
#18
Claire Greenhill
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29027994/bone-diseases-romosozumab-on-track-or-derailed
#19
Sundeep Khosla
No abstract text is available yet for this article.
December 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28984319/angiopoietin-like-3-in-lipoprotein-metabolism
#20
REVIEW
Sander Kersten
Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein particles. Three members of the angiopoietin-like (ANGPTL) protein family - ANGPTL3, ANGPTL4 and ANGPTL8 - have emerged as important regulators of plasma lipoprotein levels by inhibiting the enzyme lipoprotein lipase. Here, I review the role of ANGPTL3 in lipoprotein metabolism. In contrast to ANGPTL4 and ANGPTL8, ANGPTL3 is exclusively produced in the liver and can therefore be classified as a true hepatokine. ANGPTL3 cooperates with ANGPTL8 to inhibit lipoprotein lipase and is mostly active after feeding, whereas ANGPTL4 is mostly active after fasting...
December 2017: Nature Reviews. Endocrinology
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