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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/30446744/emerging-hormonal-based-combination-pharmacotherapies-for-the-treatment-of-metabolic-diseases
#1
REVIEW
Christoffer Clemmensen, Brian Finan, Timo D Müller, Richard D DiMarchi, Matthias H Tschöp, Susanna M Hofmann
Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease, constitute growing challenges for public health and economies globally. The available treatment options for these metabolic disorders cannot reverse the disease in most individuals and have not substantially reduced disease prevalence, which underscores the unmet need for more efficacious interventions. Neurobiological resilience to energy homeostatic perturbations, combined with the heterogeneous pathophysiology of human metabolic disorders, has limited the sustainability and efficacy of current pharmacological options...
November 16, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30446743/early-childhood-a-critical-period-for-obesity-prevention
#2
Louise A Baur, Sarah P Garnett
No abstract text is available yet for this article.
November 16, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30443043/the-calcium-sensing-receptor-in-physiology-and-in-calcitropic-and-noncalcitropic-diseases
#3
REVIEW
Fadil M Hannan, Enikö Kallay, Wenhan Chang, Maria Luisa Brandi, Rajesh V Thakker
The Ca2+ -sensing receptor (CaSR) is a dimeric family C G protein-coupled receptor that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and signals via G proteins and β-arrestin. The CaSR has a pivotal role in bone and mineral metabolism, as it regulates parathyroid hormone secretion, urinary Ca2+ excretion, skeletal development and lactation. The importance of the CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcaemia and autosomal dominant hypocalcaemia, respectively, and also by the fact that alterations in parathyroid CaSR expression contribute to the pathogenesis of primary and secondary hyperparathyroidism...
November 15, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30429579/effects-of-metformin-mediated-by-gut-microbiota
#4
Claire Greenhill
No abstract text is available yet for this article.
November 14, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30425341/new-pathways-in-development-of-liver-cancer
#5
Claire Greenhill
No abstract text is available yet for this article.
November 13, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30425340/microbiota-drives-sex-specific-differences
#6
Alan Morris
No abstract text is available yet for this article.
November 13, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30410100/microbial-metabolite-linked-to-t2dm
#7
Alan Morris
No abstract text is available yet for this article.
November 8, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30390039/targeting-two-pathways-to-treat-obesity-and-t2dm
#8
Claire Greenhill
No abstract text is available yet for this article.
November 2, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30377304/the-wave-of-sweetness-and-obesity-continues
#9
Alexandra Kautzky-Willer, Jürgen Harreiter
No abstract text is available yet for this article.
October 30, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30377303/the-predictive-power-of-an-unhealthy-metabolome
#10
Alan Morris
No abstract text is available yet for this article.
October 30, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30377302/testing-a-novel-dual-receptor-agonist-for-treatment-of-type-2-diabetes-mellitus
#11
Claire Greenhill
No abstract text is available yet for this article.
October 30, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30374163/in-utero-gene-editing-as-a-treatment-for-heritable-metabolic-syndromes
#12
Ivone Leong
No abstract text is available yet for this article.
October 29, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30367179/inhibiting-pcsk9-biology-beyond-ldl-control
#13
REVIEW
Robert M Stoekenbroek, Gilles Lambert, Bertrand Cariou, G Kees Hovingh
Clinical trials have unequivocally shown that inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by lowering levels of LDL cholesterol. PCSK9 in the circulation is derived mainly from the liver, but the protein is also expressed in the pancreas, the kidney, the intestine and the central nervous system. Although PCSK9 modulates cholesterol metabolism by regulating LDL receptor expression in the liver, in vitro and in vivo studies have suggested that PCSK9 is involved in various other physiological processes...
October 26, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30361628/the-causes-and-consequences-of-pituitary-gigantism
#14
REVIEW
Albert Beckers, Patrick Petrossians, Julien Hanson, Adrian F Daly
In the general population, height is determined by a complex interplay between genetic and environmental factors. Pituitary gigantism is a rare but very important subgroup of patients with excessive height, as it has an identifiable and clinically treatable cause. The disease is caused by chronic growth hormone and insulin-like growth factor 1 secretion from a pituitary somatotrope adenoma that forms before the closure of the epiphyses. If not controlled effectively, this hormonal hypersecretion could lead to extremely elevated final adult height...
October 25, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30356209/optical-tools-for-understanding-the-complexity-of-%C3%AE-cell-signalling-and-insulin-release
#15
REVIEW
James A Frank, Johannes Broichhagen, Dmytro A Yushchenko, Dirk Trauner, Carsten Schultz, David J Hodson
Following stimulation, pancreatic β-cells must orchestrate a plethora of signalling events to ensure the appropriate release of insulin and maintenance of normal glucose homeostasis. Failure at any point in this cascade leads to impaired insulin secretion, elevated blood levels of glucose and eventually type 2 diabetes mellitus. Likewise, β-cell replacement or regeneration strategies for the treatment of both type 1 and type 2 diabetes mellitus might fail if the correct cell signalling phenotype cannot be faithfully recreated...
October 24, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30353074/zoledronate-prevents-fractures-in-osteopenia
#16
Ivone Leong
No abstract text is available yet for this article.
October 23, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30341442/closed-loop-insulin-delivery-has-wide-ranging-benefits
#17
Alan Morris
No abstract text is available yet for this article.
October 19, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30333523/common-bisphenol-a-replacements-are-reproductive-toxicants
#18
Genoa R Warner, Jodi A Flaws
No abstract text is available yet for this article.
October 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30323277/male-hormonal-contraceptive-are-we-there-yet
#19
Stephanie T Page, John K Amory
No abstract text is available yet for this article.
October 15, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/30310152/epidemic-t2dm-early-development-and-epigenetics-implications-of-the-chinese-famine
#20
REVIEW
Paul Zimmet, Zumin Shi, Assam El-Osta, Linong Ji
The gene-environment interactions resulting from famine and the subsequent increased intergenerational risk of type 2 diabetes mellitus (T2DM) have contributed to the current epidemic of T2DM in China, which poses major social, health and economic challenges. The epidemic of T2DM could threaten national development in China through premature morbidity and mortality from T2DM and associated non-communicable diseases. The Chinese Famine (1959-1961), as a contributor to the nation's current national T2DM epidemic, provides an important and urgent public health warning...
October 11, 2018: Nature Reviews. Endocrinology
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