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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/29773871/the-somatostatin-secreting-pancreatic-%C3%AE-cell-in-health-and-disease
#1
REVIEW
Patrik Rorsman, Mark O Huising
The somatostatin-secreting δ-cells comprise ~5% of the cells of the pancreatic islets. The δ-cells have complex morphology and might interact with many more islet cells than suggested by their low numbers. δ-Cells contain ATP-sensitive potassium channels, which open at low levels of glucose but close when glucose is elevated. This closure initiates membrane depolarization and electrical activity and increased somatostatin secretion. Factors released by neighbouring α-cells or β-cells amplify the glucose-induced effects on somatostatin secretion from δ-cells, which act locally within the islets as paracrine or autocrine inhibitors of insulin, glucagon and somatostatin secretion...
May 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29773870/an-update-in-the-treatment-preference-for-hyperthyroidism
#2
LETTER
Obin Kwon
No abstract text is available yet for this article.
May 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29773869/accurate-diagnosis-of-diabetes-mellitus-and-new-paradigms-of-classification
#3
Sudesna Chatterjee, Melanie J Davies
No abstract text is available yet for this article.
May 17, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29769694/aldob-promotes-liver-metastases-development
#4
Ivone Leong
No abstract text is available yet for this article.
May 16, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29769693/caring-for-individuals-with-a-difference-of-sex-development-dsd-a-consensus-statement
#5
REVIEW
Martine Cools, Anna Nordenström, Ralitsa Robeva, Joanne Hall, Puck Westerveld, Christa Flück, Birgit Köhler, Marta Berra, Alexander Springer, Katinka Schweizer, Vickie Pasterski
The term differences of sex development (DSDs; also known as disorders of sex development) refers to a heterogeneous group of congenital conditions affecting human sex determination and differentiation. Several reports highlighting suboptimal physical and psychosexual outcomes in individuals who have a DSD led to a radical revision of nomenclature and management a decade ago. Whereas the resulting recommendations for holistic, multidisciplinary care seem to have been implemented rapidly in specialized paediatric services around the world, adolescents often experience difficulties in finding access to expert adult care and gradually or abruptly cease medical follow-up...
May 16, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29765134/low-protein-diet-in-cancer-ready-for-prime-time
#6
Roberto Pili, Luigi Fontana
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29765133/bat-talks-to-muscles
#7
Ivone Leong
No abstract text is available yet for this article.
May 15, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29748639/palmitate-is-not-a-tlr4-agonist
#8
Alan Morris
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29748638/link-between-fgf21-and-blood-pressure
#9
Claire Greenhill
No abstract text is available yet for this article.
May 10, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29740147/sphingolipids-involved-in-t1dm
#10
Claire Greenhill
No abstract text is available yet for this article.
May 9, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29728598/glucagon-like-peptide-1-in-health-and-disease
#11
REVIEW
Andreas Andersen, Asger Lund, Filip K Knop, Tina Vilsbøll
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates insulin release and suppresses glucagon secretion in response to the ingestion of nutrients. GLP1 also delays gastric emptying and increases satiety. In patients with type 2 diabetes mellitus (T2DM), supraphysiological doses of GLP1 normalize the endogenous insulin response during a hyperglycaemic clamp. Owing to the short plasma half-life of native GLP1, several GLP1 receptor agonists (GLP1RAs) with longer half-lives have been developed for the treatment of T2DM...
May 4, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29720676/making-waves-against-a-tsunami-of-childhood-obesity
#12
Kim D Raine
No abstract text is available yet for this article.
May 2, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29700383/role-for-s-aureus-in-insulin-resistance
#13
Claire Greenhill
No abstract text is available yet for this article.
April 26, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29692412/are-you-thirsty-fgf21-might-be-involved-in-that-too
#14
Alan Morris
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29692411/exercise-affects-gut-microbiota-and-bone
#15
Claire Greenhill
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29692410/p62-a-new-metabolic-tumour-suppressor
#16
Ivone Leong
No abstract text is available yet for this article.
April 24, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29686432/targeting-autophagy-in-obesity-from-pathophysiology-to-management
#17
REVIEW
Yingmei Zhang, James R Sowers, Jun Ren
Obesity poses a severe threat to human health, including the increased prevalence of hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and other chronic diseases. Current therapies focus mainly on suppressing caloric intake, but the efficacy of this approach remains poor. A better understanding of the pathophysiology of obesity will be essential for the management of obesity and its complications. Knowledge gained over the past three decades regarding the aetiological mechanisms underpinning obesity has provided a framework that emphasizes energy imbalance and neurohormonal dysregulation, which are tightly regulated by autophagy...
April 23, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29686431/the-reaven-syndrome-a-tribute-to-a-giant
#18
Jean-Pierre Després
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29686430/inhibiting-glycolysis-in-tumour-cells
#19
Alan Morris
No abstract text is available yet for this article.
April 23, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29670179/antithyroid-drugs-and-congenital-malformations
#20
Tim I M Korevaar, Robin P Peeters
No abstract text is available yet for this article.
April 18, 2018: Nature Reviews. Endocrinology
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