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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/28731035/growth-and-development-dwarfism-linked-to-hypertension-treatment
#1
David Holmes
No abstract text is available yet for this article.
July 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28731034/regulation-of-hepatic-glucose-metabolism-in-health-and-disease
#2
REVIEW
Max C Petersen, Daniel F Vatner, Gerald I Shulman
The liver is crucial for the maintenance of normal glucose homeostasis - it produces glucose during fasting and stores glucose postprandially. However, these hepatic processes are dysregulated in type 1 and type 2 diabetes mellitus, and this imbalance contributes to hyperglycaemia in the fasted and postprandial states. Net hepatic glucose production is the summation of glucose fluxes from gluconeogenesis, glycogenolysis, glycogen synthesis, glycolysis and other pathways. In this Review, we discuss the in vivo regulation of these hepatic glucose fluxes...
July 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707681/liver-paradigm-shift-in-the-immunopathogenesis-of-nafld
#3
David Holmes
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707680/targeted-therapies-lenvatinib-selects-survival-benefit
#4
Lisa Hutchinson
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707679/anaplastic-thyroid-carcinoma-from-clinicopathology-to-genetics-and-advanced-therapies
#5
REVIEW
Eleonora Molinaro, Cristina Romei, Agnese Biagini, Elena Sabini, Laura Agate, Salvatore Mazzeo, Gabriele Materazzi, Stefano Sellari-Franceschini, Alessandro Ribechini, Liborio Torregrossa, Fulvio Basolo, Paolo Vitti, Rossella Elisei
Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1-2% of all thyroid cancers. Although rare, ATC accounts for the majority of deaths from thyroid carcinoma. ATC often originates in a pre-existing thyroid cancer lesion, as suggested by the simultaneous presence of areas of differentiated or poorly differentiated thyroid carcinoma. ATC is characterized by the accumulation of several oncogenic alterations, and studies have shown that an increased number of oncogenic alterations equates to an increased level of dedifferentiation and aggressiveness...
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707678/cardiovascular-endocrinology-is-angptl3-the-next-pcsk9
#6
Kiran Musunuru, Sekar Kathiresan
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707677/-omics-and-endocrine-disrupting-chemicals-new-paths-forward
#7
REVIEW
Carmen Messerlian, Rosie M Martinez, Russ Hauser, Andrea A Baccarelli
The emerging field of omics - large-scale data-rich biological measurements of the genome - provides new opportunities to advance and strengthen research into endocrine-disrupting chemicals (EDCs). Although some EDCs have been associated with adverse health effects in humans, our understanding of their impact remains incomplete. Progress in the field has been primarily limited by our inability to adequately estimate and characterize exposure and identify sensitive and measurable outcomes during windows of vulnerability...
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707676/obesity-olfactory-senses-linked-to-metabolism
#8
Alan Morris
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28685769/%C3%AE-cell-mass-versus-function-in-type-1-diabetes-mellitus-truth-or-dare
#9
Teresa Rodriguez-Calvo, Mark Atkinson, Matthias von Herrath
No abstract text is available yet for this article.
July 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28685768/obesity-gut-microbiome-and-serum-metabolome-changes
#10
Claire Greenhill
No abstract text is available yet for this article.
July 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28685767/type-1-diabetes-mellitus-is-a-heterogeneous-disease
#11
Mikael Knip
No abstract text is available yet for this article.
July 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28685766/gut-microbiota-link-between-the-gut-and-adipose-tissues
#12
Alan Morris
No abstract text is available yet for this article.
July 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28664920/fgf1-a-new-weapon-to-control-type-2-diabetes-mellitus
#13
REVIEW
Emanuel Gasser, Christopher P Moutos, Michael Downes, Ronald M Evans
A hypercaloric diet combined with a sedentary lifestyle is a major risk factor for the development of insulin resistance, type 2 diabetes mellitus (T2DM) and associated comorbidities. Standard treatment for T2DM begins with lifestyle modification, and includes oral medications and insulin therapy to compensate for progressive β-cell failure. However, current pharmaceutical options for T2DM are limited in that they do not maintain stable, durable glucose control without the need for treatment intensification...
June 30, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28664919/type-2-diabetes-mellitus-and-psychological-stress-a-modifiable-risk-factor
#14
REVIEW
Ruth A Hackett, Andrew Steptoe
Psychological stress is common in many physical illnesses and is increasingly recognized as a risk factor for disease onset and progression. An emerging body of literature suggests that stress has a role in the aetiology of type 2 diabetes mellitus (T2DM) both as a predictor of new onset T2DM and as a prognostic factor in people with existing T2DM. Here, we review the evidence linking T2DM and psychological stress. We highlight the physiological responses to stress that are probably related to T2DM, drawing on evidence from animal work, large epidemiological studies and human laboratory trials...
June 30, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28621341/the-gentle-art-of-saying-no-how-nitric-oxide-gets-things-done-in-the-hypothalamus
#15
REVIEW
Konstantina Chachlaki, John Garthwaite, Vincent Prevot
The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous and lipid environments, subserves an array of functions in the mammalian central nervous system, such as the regulation of synaptic plasticity, blood flow and neurohormone secretion. In this Review, we consider the cellular and molecular mechanisms by which NO evokes short-term and long-term changes in neuronal activity. We also highlight recent studies showing that discrete populations of neurons that synthesize NO in the hypothalamus constitute integrative systems that support life by relaying metabolic and gonadal signals to the neuroendocrine brain, and thus gate the onset of puberty and adult fertility...
June 16, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28621338/adipose-tissue-crosstalk-between-adipocytes-and-neurons
#16
Claire Greenhill
No abstract text is available yet for this article.
June 16, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28621339/hepatokines-linking-nonalcoholic-fatty-liver-disease-and-insulin-resistance
#17
REVIEW
Ruth C R Meex, Matthew J Watt
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which is the most common form of liver disease and is present in up to ∼70% of individuals who are overweight. NAFLD is also associated with hypertriglyceridaemia and low levels of HDL, glucose intolerance, insulin resistance and type 2 diabetes mellitus. Hepatic steatosis is a strong predictor of the development of insulin resistance and often precedes the onset of other known mediators of insulin resistance. This sequence of events suggests that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle...
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28621335/in-the-news-ece2017-highlights-from-the-meeting
#18
Alan Morris
No abstract text is available yet for this article.
June 9, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28549061/central-hypothyroidism-a-neglected-thyroid-disorder
#19
REVIEW
Paolo Beck-Peccoz, Giulia Rodari, Claudia Giavoli, Andrea Lania
Central hypothyroidism is a rare and heterogeneous disorder that is characterized by a defect in thyroid hormone secretion in an otherwise normal thyroid gland due to insufficient stimulation by TSH. The disease results from the abnormal function of the pituitary gland, the hypothalamus, or both. Moreover, central hypothyroidism can be isolated or combined with other pituitary hormone deficiencies, which are mostly acquired and are rarely congenital. The clinical manifestations of central hypothyroidism are usually milder than those observed in primary hypothyroidism...
May 26, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28524168/endocrine-disrupting-chemicals-and-the-regulation-of-energy-balance
#20
REVIEW
Angel Nadal, Ivan Quesada, Eva Tudurí, Rubén Nogueiras, Paloma Alonso-Magdalena
Energy balance involves the adjustment of food intake, energy expenditure and body fat reserves through homeostatic pathways. These pathways include a multitude of biochemical reactions, as well as hormonal cues. Dysfunction of this homeostatic control system results in common metabolism-related pathologies, which include obesity and type 2 diabetes mellitus. Metabolism-disrupting chemicals (MDCs) are a particular class of endocrine-disrupting chemicals that affect energy homeostasis. MDCs affect multiple endocrine mechanisms and thus different cell types that are implicated in metabolic control...
May 19, 2017: Nature Reviews. Endocrinology
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