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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/28429780/insulin-analogues-in-type-1-diabetes-mellitus-getting-better-all-the-time
#1
REVIEW
Chantal Mathieu, Pieter Gillard, Katrien Benhalima
The treatment of type 1 diabetes mellitus consists of external replacement of the functions of β cells in an attempt to achieve blood levels of glucose as close to the normal range as possible. This approach means that glucose sensing needs to be replaced and levels of insulin need to mimic physiological insulin-action profiles, including basal coverage and changes around meals. Training and educating patients are crucial for the achievement of good glycaemic control, but having insulin preparations with action profiles that provide stable basal insulin coverage and appropriate mealtime insulin peaks helps people with type 1 diabetes mellitus to live active lives without sacrificing tight glycaemic control...
April 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28429779/metabolism-adipose-and-nonadipose-effects-of-fgf21-delineated
#2
David Holmes
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28429778/reproductive-endocrinology-potential-new-therapy-for-hot-flushes
#3
Claire Greenhill
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28418016/pituitary-function-pulsatile-gnrh-therapy-in-ccphd
#4
Claire Greenhill
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28418015/diabetes-lmptp-inhibitors-potential-treatment-for-type-2-diabetes
#5
Alan Morris
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28387322/adipose-tissue-towards-mimicking-cold-exposure
#6
Claire Greenhill
No abstract text is available yet for this article.
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28387321/immunometabolism-er-stress-drives-obesity-by-reducing-energy-expenditure
#7
David Holmes
No abstract text is available yet for this article.
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28387320/endocrine-disruptors-chemical-contaminants-a-toxic-mixture-for-neurodevelopment
#8
Morgan E Hernandez, Andrea C Gore
No abstract text is available yet for this article.
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28387319/trial-watch-insulin-initiation-for-type-2-diabetes-mellitus-in-primary-care
#9
Melanie J Davies, Sudesna Chatterjee
No abstract text is available yet for this article.
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28387318/comparative-analysis-of-nutritional-guidelines-for-vitamin-d
#10
REVIEW
Roger Bouillon
Vitamin D is essential for calcium and bone homeostasis. Humans are largely dependent on UVB-radiation-induced photosynthesis of vitamin D, as few foods contain vitamin D. However, the same radiation that produces vitamin D is also carcinogenic, albeit with a long lag time, and causes DNA damage. In view of the increasing life expectancy, avoiding excessive sun exposure is prudent. Several groups of people have a shortfall between their requirements for vitamin D and their combined endogenous synthesis and intake from natural foods, and therefore need vitamin D supplementation...
April 7, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28361929/metabolism-liver-and-adipose-tissue-control-uridine-biosynthesis
#11
Claire Greenhill
No abstract text is available yet for this article.
March 31, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28361927/molecular-profiling-of-thyroid-nodule-fine-needle-aspiration-cytology
#12
REVIEW
Markus Eszlinger, Lorraine Lau, Sana Ghaznavi, Christopher Symonds, Shamir P Chandarana, Moosa Khalil, Ralf Paschke
The differential diagnosis and malignancy risk stratification of thyroid nodules requires multidisciplinary expertise and knowledge of both local ultrasonography practices and the local malignancy rates for a given fine-needle aspiration (FNA) result. Even in such a multidisciplinary setting, FNA cytology has the inherent limitation that indeterminate cytology results cannot distinguish between follicular adenomas, follicular thyroid carcinomas or follicular variant papillary thyroid carcinomas. Accumulating evidence suggests that this limitation can be overcome by using molecular diagnostic approaches...
March 31, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28338662/diabetes-pancreatic-glp1-is-involved-in-glucose-regulation
#13
Alan Morris
No abstract text is available yet for this article.
March 24, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28338661/adipose-tissue-new-route-to-functional-human-beige-adipocytes
#14
David Holmes
No abstract text is available yet for this article.
March 24, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28338660/germline-and-somatic-genetics-of-osteosarcoma-connecting-aetiology-biology-and-therapy
#15
REVIEW
D Matthew Gianferante, Lisa Mirabello, Sharon A Savage
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary cancer of bone, have changed very little over the past 30 years. The peak incidence of osteosarcoma occurs during the adolescent growth spurt, which suggests that bone growth and pubertal hormones are important in the aetiology of the disease. Tall stature, high birth weight and certain inherited cancer predisposition syndromes are well-described risk factors for osteosarcoma. Common genetic variants are also associated with osteosarcoma...
March 24, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28304394/bone-osteoblast-derived-lipocalin-2-suppresses-appetite
#16
Claire Greenhill
No abstract text is available yet for this article.
March 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28304393/the-effects-of-oestrogens-and-their-receptors-on-cardiometabolic-health
#17
REVIEW
Eugenia Morselli, Roberta S Santos, Alfredo Criollo, Michael D Nelson, Biff F Palmer, Deborah J Clegg
Cardiovascular disease (CVD) is one of the leading causes of mortality in developed countries. The incidence of CVD is sexually dimorphic, and research has focused on the contribution of sex steroids to the development and progression of the cardiometabolic syndrome, which is defined as a clustering of interrelated risk factors that promote the development of atherosclerosis (which can lead to CVD) and type 2 diabetes mellitus. Data are inconclusive as to how sex steroids and their respective receptors increase or suppress the risk of developing the cardiometabolic syndrome and thus CVD...
March 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28304392/metrics-for-glycaemic-control-from-hba1c-to-continuous-glucose-monitoring
#18
REVIEW
Boris P Kovatchev
As intensive treatment to lower levels of HbA1c characteristically results in an increased risk of hypoglycaemia, patients with diabetes mellitus face a life-long optimization problem to reduce average levels of glycaemia and postprandial hyperglycaemia while simultaneously avoiding hypoglycaemia. This optimization can only be achieved in the context of lowering glucose variability. In this Review, I discuss topics that are related to the assessment, quantification and optimal control of glucose fluctuations in diabetes mellitus...
March 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28304390/metabolism-exercise-resistance-decoded
#19
David Holmes
No abstract text is available yet for this article.
March 17, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28281567/diabetes-fasting-and-%C3%AE-cell-regeneration
#20
Conor A Bradley
No abstract text is available yet for this article.
March 10, 2017: Nature Reviews. Endocrinology
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