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Nature Reviews. Endocrinology

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https://www.readbyqxmd.com/read/28914271/surgery-postprandial-hypoglycaemia-following-bariatric-surgery
#1
Alan Morris
No abstract text is available yet for this article.
September 15, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28914270/transplantation-cxcl10-linked-to-poor-outcomes
#2
David Holmes
No abstract text is available yet for this article.
September 15, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885625/obesity-role-for-creatine-metabolism-in-energy-expenditure
#3
Claire Greenhill
No abstract text is available yet for this article.
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885624/bone-diseases-new-hope-for-old-bones
#4
David Holmes
No abstract text is available yet for this article.
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885623/chronic-endocrine-consequences-of-traumatic-brain-injury-what-is-the-evidence
#5
REVIEW
Marianne Klose, Ulla Feldt-Rasmussen
Traumatic brain injury (TBI) is a major public health problem with potentially debilitating consequences for the individual. Hypopituitarism after TBI has received increasing attention over the past decade; development of the condition as a consequence of TBI was previously hardly mentioned in textbooks on the subject. Hypopituitarism has been reported in more than 25% of patients with TBI and is now thought to be one of the most important causes of treatable morbidity in TBI survivors. However, most clinicians dealing with neuroendocrine diseases and TBI generally do not see such a high incidence of hypopituitarism...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885622/adult-onset-autoimmune-diabetes-current-knowledge-and-implications-for-management
#6
REVIEW
Raffaella Buzzetti, Simona Zampetti, Ernesto Maddaloni
Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a reduced genetic load, a less intensive autoimmune process and a mild metabolic decompensation at onset compared with young-onset type 1 diabetes mellitus (T1DM). The majority of patients with adult-onset autoimmune diabetes do not require insulin treatment for at least 6 months after diagnosis. Such patients are defined as having latent autoimmune diabetes in adults (LADA), which is distinct from classic adult-onset T1DM. The extensive heterogeneity of adult-onset autoimmune diabetes is apparent beyond the distinction between classic adult-onset T1DM and LADA...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28885621/primary-hyperparathyroidism
#7
REVIEW
Marcella D Walker, Shonni J Silverberg
In this Review, we describe the pathogenesis, diagnosis and management of primary hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a common endocrine disorder that is characterized by hypercalcaemia and elevated or inappropriately normal serum levels of parathyroid hormone. Most often, the presentation of PHPT is asymptomatic in regions of the world where serum levels of calcium are routinely measured. In addition to mild hypercalcaemia, PHPT can manifest with osteoporosis and hypercalciuria as well as with vertebral fractures and nephrolithiasis, both of which can be asymptomatic...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28862266/genomic-and-epigenomic-mechanisms-of-glucocorticoids-in-the-brain
#8
REVIEW
Jason D Gray, Joshua F Kogan, Jordan Marrocco, Bruce S McEwen
Following the discovery of glucocorticoid receptors in the hippocampus and other brain regions, research has focused on understanding the effects of glucocorticoids in the brain and their role in regulating emotion and cognition. Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload. Allostatic overload, which can occur during chronic stress, can reshape the hypothalamic-pituitary-adrenal axis through epigenetic modification of genes in the hippocampus, hypothalamus and other stress-responsive brain regions...
September 1, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28849786/srebp-regulated-lipid-metabolism-convergent-physiology-divergent-pathophysiology
#9
REVIEW
Hitoshi Shimano, Ryuichiro Sato
Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element binding proteins (SREBPs). In addition to performing canonical functions in the transcriptional regulation of genes involved in the biosynthesis and uptake of lipids, genome-wide system analyses have revealed that these versatile transcription factors act as important nodes of convergence and divergence within biological signalling networks. Thus, they are involved in myriad physiological and pathophysiological processes, highlighting the importance of lipid metabolism in biology...
August 29, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28820505/gut-microbiota-gas-induced-glp1-release
#10
David Holmes
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28820503/diabetes-systemic-effects-of-metformin-revealed
#11
Alan Morris
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28799554/adapting-to-obesity-with-adipose-tissue-inflammation
#12
REVIEW
Shannon M Reilly, Alan R Saltiel
Adipose tissue not only has an important role in the storage of excess nutrients but also senses nutrient status and regulates energy mobilization. An overall positive energy balance is associated with overnutrition and leads to excessive accumulation of fat in adipocytes. These cells respond by initiating an inflammatory response that, although maladaptive in the long run, might initially be a physiological response to the stresses obesity places on adipose tissue. In this Review, we characterize adipose tissue inflammation and review the current knowledge of what triggers obesity-associated inflammation in adipose tissue...
August 11, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28731035/growth-and-development-dwarfism-linked-to-hypertension-treatment
#13
David Holmes
No abstract text is available yet for this article.
July 21, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707681/liver-paradigm-shift-in-the-immunopathogenesis-of-nafld
#14
David Holmes
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707680/targeted-therapies-lenvatinib-selects-survival-benefit
#15
Lisa Hutchinson
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707679/anaplastic-thyroid-carcinoma-from-clinicopathology-to-genetics-and-advanced-therapies
#16
REVIEW
Eleonora Molinaro, Cristina Romei, Agnese Biagini, Elena Sabini, Laura Agate, Salvatore Mazzeo, Gabriele Materazzi, Stefano Sellari-Franceschini, Alessandro Ribechini, Liborio Torregrossa, Fulvio Basolo, Paolo Vitti, Rossella Elisei
Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1-2% of all thyroid cancers. Although rare, ATC accounts for the majority of deaths from thyroid carcinoma. ATC often originates in a pre-existing thyroid cancer lesion, as suggested by the simultaneous presence of areas of differentiated or poorly differentiated thyroid carcinoma. ATC is characterized by the accumulation of several oncogenic alterations, and studies have shown that an increased number of oncogenic alterations equates to an increased level of dedifferentiation and aggressiveness...
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707678/cardiovascular-endocrinology-is-angptl3-the-next-pcsk9
#17
Kiran Musunuru, Sekar Kathiresan
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707677/-omics-and-endocrine-disrupting-chemicals-new-paths-forward
#18
REVIEW
Carmen Messerlian, Rosie M Martinez, Russ Hauser, Andrea A Baccarelli
The emerging field of omics - large-scale data-rich biological measurements of the genome - provides new opportunities to advance and strengthen research into endocrine-disrupting chemicals (EDCs). Although some EDCs have been associated with adverse health effects in humans, our understanding of their impact remains incomplete. Progress in the field has been primarily limited by our inability to adequately estimate and characterize exposure and identify sensitive and measurable outcomes during windows of vulnerability...
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28707676/obesity-olfactory-senses-linked-to-metabolism
#19
Alan Morris
No abstract text is available yet for this article.
July 14, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28685767/type-1-diabetes-mellitus-is-a-heterogeneous-disease
#20
Mikael Knip
No abstract text is available yet for this article.
July 7, 2017: Nature Reviews. Endocrinology
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