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Nature Reviews. Cardiology

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https://www.readbyqxmd.com/read/28332500/cardiovascular-effects-of-electronic-cigarettes
#1
REVIEW
Neal L Benowitz, Joseph B Fraiman
Cardiovascular safety is an important consideration in the debate on the benefits versus the risks of electronic cigarette (EC) use. EC emissions that might have adverse effects on cardiovascular health include nicotine, oxidants, aldehydes, particulates, and flavourants. To date, most of the cardiovascular effects of ECs demonstrated in humans are consistent with the known effects of nicotine. Pharmacological and toxicological studies support the biological plausibility that nicotine contributes to acute cardiovascular events and accelerated atherogenesis...
March 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28300082/inflammatory-processes-in-cardiovascular-disease-a-route-to-targeted-therapies
#2
Neil Ruparelia, Joshua T Chai, Edward A Fisher, Robin P Choudhury
No abstract text is available yet for this article.
March 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28300081/effects-of-dyslipidaemia-on-monocyte-production-and-function-in-cardiovascular-disease
#3
REVIEW
Mohammed Shamim Rahman, Andrew J Murphy, Kevin J Woollard
Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. Monocytes and macrophages are involved in cardiovascular disease progression, and are associated with the development of unstable atherosclerotic plaques. Hyperlipidaemia can accelerate cardiovascular disease progression. However, monocyte responses to hyperlipidaemia are poorly understood. In the past decade, accumulating data describe the relationship between the dynamic blood lipid environment and the heterogeneous circulating monocyte pool, which might have profound consequences for cardiovascular disease...
March 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28300080/hypertriglyceridaemia-and-risk-of-coronary-artery-disease
#4
REVIEW
Željko Reiner
An elevated serum level of LDL cholesterol is a well-known risk factor for cardiovascular disease (CVD), but the role of elevated triglyceride levels is debated. Controversies regarding hypertriglyceridaemia as an independent risk factor for CVD have occurred partly because elevated triglyceride levels are often a component of atherogenic dyslipidaemia - they are associated with decreased levels of HDL cholesterol and increased levels of small dense LDL particles, which are highly atherogenic. Findings from several large studies indicate that elevated levels of triglycerides (either fasting or nonfasting) or, more specifically, triglyceride-rich lipoproteins and their remnants, are independently associated with increased risk of CVD...
March 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28275246/sarcoplasmic-reticulum-mitochondria-communication-in-cardiovascular-pathophysiology
#5
REVIEW
Camila Lopez-Crisosto, Christian Pennanen, Cesar Vasquez-Trincado, Pablo E Morales, Roberto Bravo-Sagua, Andrew F G Quest, Mario Chiong, Sergio Lavandero
Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent on a sustained energy supply and adequate calcium buffering, both of which are provided by mitochondria. Moreover, in vascular smooth muscle cells, mitochondrial metabolism modulates cell growth and proliferation, whereas cytosolic calcium levels regulate the arterial vascular tone. Physical and functional communication between mitochondria and sarco/endoplasmic reticulum and balanced mitochondrial dynamics seem to have a critical role for optimal calcium transfer to mitochondria, which is crucial in calcium homeostasis and mitochondrial metabolism in both types of muscle cells...
March 9, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28230176/antithrombotic-therapy-for-patients-with-stemi-undergoing-primary-pci
#6
REVIEW
Francesco Franchi, Fabiana Rollini, Dominick J Angiolillo
Antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Intravenous anticoagulant drugs available for PPCI include the indirect thrombin inhibitors unfractionated heparin and low-molecular-weight heparin, and the direct thrombin inhibitor bivalirudin. Intravenous antiplatelet drugs mainly include glycoprotein IIb/IIIa inhibitors and the P2Y12-receptor inhibitor cangrelor...
February 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28230175/cardiovascular-disease-in-africa-epidemiological-profile-and-challenges
#7
REVIEW
Ashley K Keates, Ana O Mocumbi, Mpiko Ntsekhe, Karen Sliwa, Simon Stewart
From a global perspective, the large and diverse African population is disproportionately affected by cardiovascular disease (CVD). The historical balance between communicable and noncommunicable pathways to CVD in different African regions is dependent on external factors over the life course and at a societal level. The future risk of noncommunicable forms of CVD (predominantly driven by increased rates of hypertension, smoking, and obesity) is a growing public health concern. The incidence of previously rare forms of CVD such as coronary artery disease will increase, in concert with historically prevalent forms of disease, such as rheumatic heart disease, that are yet to be optimally prevented or treated...
February 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28181585/single-or-dual-antiplatelet-therapy-after-pci
#8
REVIEW
Yosuke Miyazaki, Pannipa Suwannasom, Yohei Sotomi, Mohammad Abdelghani, Karthik Tummala, Yuki Katagiri, Taku Asano, Erhan Tenekecioglu, Yaping Zeng, Rafael Cavalcante, Carlos Collet, Yoshinobu Onuma, Patrick W Serruys
The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. At the time of the first-in-man implantation of the sirolimus DES in 1999, the protocol-defined dual antiplatelet therapy (DAPT) duration was only 2 months. Subsequently, DAPT duration was extended to 1 year on the basis of anecdotal historical data, and this practice was then incorporated into clinical guidelines. For >1 decade, trialists have sought to compare the safety and efficacy of abbreviated (<6 months) and prolonged (>12 months) DAPT regimens...
February 9, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150806/dyslipidaemia-small-triumph-for-fenofibrate-therapy-in-dyslipidaemia
#9
Robert S Rosenson
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150805/venous-thromboembolism-thromboprophylaxis-with-statins
#10
Gregory B Lim
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150804/extracellular-vesicles-in-coronary-artery-disease
#11
REVIEW
Chantal M Boulanger, Xavier Loyer, Pierre-Emmanuel Rautou, Nicolas Amabile
Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesicles as regulators of transfer of biological information, acting locally and remotely, is now acknowledged. Circulating vesicles released from platelets, erythrocytes, leukocytes, and endothelial cells contain potential valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease...
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150803/vascular-disease-cell-therapy-lowers-pad-amputation-risk
#12
Karina Huynh
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127031/risk-factors-linking-stress-to-arterial-inflammation-and-vascular-events
#13
Gregory B Lim
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127030/acute-coronary-syndromes-microbial-dependent-tmao-as-a-prognostic-marker-in-acs
#14
Irene Fernández-Ruiz
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127028/natural-killer-t-cells-in-atherosclerosis
#15
REVIEW
Godfrey S Getz, Catherine A Reardon
Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT) cells in response to microbial pathogens and inflammatory disorders such as atherosclerosis has received increasing attention in the past 10-15 years. Endogenous self-lipid antigens and exogenous lipid antigens, including those on microorganisms can activate NKT cells...
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102234/heart-failure-recombinant-neuregulin-for-hf-treatment
#16
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102233/arrhythmias-optogenetic-control-of-cardiac-rhythm
#17
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102231/cell-therapy-autologous-cardiac-stem-cells-for-congenital-hf
#18
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28079111/killing-the-old-cell-senescence-in-atherosclerosis
#19
Martin R Bennett, Murray C H Clarke
No abstract text is available yet for this article.
January 12, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28054580/nlrp3-inflammasome-common-nexus-between-depression-and-cardiovascular-diseases
#20
Elísabet Alcocer-Gómez, Mario D Cordero
No abstract text is available yet for this article.
January 5, 2017: Nature Reviews. Cardiology
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