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Nature Reviews. Cardiology

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https://www.readbyqxmd.com/read/28726853/dyslipidaemia-effect-of-hypercholesterolaemia-on-hdl-particle-remodelling
#1
Gregory B Lim
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28726852/autoimmune-channelopathies-questions-remain
#2
Jin Li, Ange Maguy
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28726851/autoimmune-cardiac-channelopathies-the-heart-of-the-matter
#3
Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Mohamed Boutjdir
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28726850/growth-and-development-poly-a-tail-based-regulation-of-cardiac-hypertrophy
#4
Irene Fernández-Ruiz
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28703224/basic-research-new-cardiomyocyte-formation-in-adult-mouse-hearts
#5
Karina Huynh
No abstract text is available yet for this article.
July 13, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28703223/unmasking-the-molecular-link-between-arrhythmogenic-cardiomyopathy-and-brugada-syndrome
#6
REVIEW
Javier Moncayo-Arlandi, Ramon Brugada
The intercalated discs that connect cardiomyocytes control cell-to-cell adhesion and communication. Several macromolecular structures (desmosomes, fascia adherens junctions, gap junctions, and sodium-channel complexes) coexist in, and confer their mechanical and electrical properties to, the intercalated disc. Traditionally, each structure was assumed to have a unique function in the intercalated disc. However, growing evidence suggests that these complexes act together in intercellular communication and adhesion, forming a single structural and functional entity - the connexome...
July 13, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28682324/matching-patients-with-the-ever-expanding-range-of-tavi-devices
#7
REVIEW
Brandon M Jones, Amar Krishnaswamy, E Murat Tuzcu, Stephanie Mick, Wael A Jaber, Lars G Svensson, Samir R Kapadia
Transcatheter aortic valve implantation (TAVI) has become a widely accepted strategy for the treatment of aortic stenosis in patients at intermediate, high, or prohibitive surgical risk. After >1 decade of innovation and clinical trial experience, the available technology for TAVI has grown enormously, and now includes a myriad of vascular access approaches and innovative valve designs. As a result, the range of patients who can benefit from these advances continues to grow rapidly. Furthermore, given the improved safety profile and clinical success of current-generation devices in randomized trials, the use of TAVI among even low-risk populations is justified in current trials...
July 6, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28682320/management-of-atrial-high-rate-episodes-detected-by-cardiac-implanted-electronic-devices
#8
REVIEW
Ben Freedman, Giuseppe Boriani, Taya V Glotzer, Jeff S Healey, Paulus Kirchhof, Tatjana S Potpara
Cardiac implanted electronic devices (CIEDs), including pacemakers and implantable defibrillators that perform atrial sensing typically using an atrial electrode, frequently detect subclinical atrial high-rate episodes (AHREs). When the intracardiac electrograms are carefully examined, the majority of AHREs are atrial fibrillation (AF) or other atrial tachyarrhythmias, which have been shown to be associated with both an increased risk of stroke, and subsequent development of clinical AF. However, the absolute risk of stroke among patients with AHREs is less than might be expected for clinically diagnosed paroxysmal AF...
July 6, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28660894/proteostasis-in-cardiac-health-and-disease
#9
REVIEW
Robert H Henning, Bianca J J M Brundel
The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing. Prevailing theories about the mechanisms of ageing feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of protein quality control as central factors. In the heart, loss of protein patency, owing to flaws in genetically-determined design or because of environmentally-induced 'wear and tear', can overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac ageing...
June 29, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28660892/reperfusion-strategies-in-acute-myocardial-infarction-and-multivessel-disease
#10
REVIEW
Birgit Vogel, Shamir R Mehta, Roxana Mehran
Approximately 50% of patients with ST-segment elevation myocardial infarction (STEMI) have multivessel disease. The optimal reperfusion strategy in these patients is still uncertain. Whether percutaneous coronary intervention (PCI) of only the culprit vessel or a strategy of complete revascularization, either in a simultaneous or staged multivessel PCI approach, should be performed remains unclear. Although a large number of observational studies have mostly shown worse clinical outcomes associated with a multivessel PCI approach, increasing evidence from randomized controlled trials suggests that multivessel PCI is safe, while reducing the need for revascularization in selected patients, compared with culprit vessel-only PCI...
June 29, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28660891/vascular-disease-treatment-of-ischaemic-vascular-disease-with-3d-printed-vessels
#11
Gregory B Lim
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28593996/epidemiology-and-treatment-of-pulmonary-arterial-hypertension
#12
REVIEW
Edmund M T Lau, Eleni Giannoulatou, David S Celermajer, Marc Humbert
In the past 2 decades, major changes have occurred in the epidemiological and treatment landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of the young and middle-aged, contemporary registries from the Western world have demonstrated an increase in the age of patients with PAH, many of whom are elderly with multiple comorbidities. Another important observation is the improvement in survival of patients with PAH in the modern treatment era compared with historical cohorts, before the availability of advanced therapy...
June 8, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28569269/mendelian-randomization-in-cardiometabolic-disease-challenges-in-evaluating-causality
#13
REVIEW
Michael V Holmes, Mika Ala-Korpela, George Davey Smith
Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to assess causal relationships between exposures and outcomes. MR studies can be straightforward; for example, genetic variants within or near the encoding locus that is associated with protein concentrations can help to assess their causal role in disease. However, a more complex relationship between the genetic variants and an exposure can make findings from MR more difficult to interpret. In this Review, we describe some of these challenges in interpreting MR analyses, including those from studies using genetic variants to assess causality of multiple traits (such as branched-chain amino acids and risk of diabetes mellitus); studies describing pleiotropic variants (for example, C-reactive protein and its contribution to coronary heart disease); and those investigating variants that disrupt normal function of an exposure (for example, HDL cholesterol or IL-6 and coronary heart disease)...
June 1, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28518178/physical-function-and-exercise-training-in-older-patients-with-heart-failure
#14
REVIEW
Andrew J Stewart Coats, Daniel E Forman, Mark Haykowsky, Dalane W Kitzman, Amy McNeil, Tavis S Campbell, Ross Arena
Heart failure (HF) is a common end point for numerous cardiovascular conditions, including coronary artery disease, valvular disease, and hypertension. HF predominantly affects older individuals (aged ≥70 years), particularly those living in developed countries. The pathophysiological sequelae of HF progression have a substantial negative effect on physical function. Diminished physical function in older patients with HF, which is the result of combined disease-related and age-related effects, has important implications on health...
May 18, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28518176/seasonal-variations-in-cardiovascular-disease
#15
REVIEW
Simon Stewart, Ashley K Keates, Adele Redfern, John J V McMurray
Cardiovascular disease (CVD) follows a seasonal pattern in many populations. Broadly defined winter peaks and clusters of all subtypes of CVD after 'cold snaps' are consistently described, with corollary peaks linked to heat waves. Individuals living in milder climates might be more vulnerable to seasonality. Although seasonal variation in CVD is largely driven by predictable changes in weather conditions, a complex interaction between ambient environmental conditions and the individual is evident. Behavioural and physiological responses to seasonal change modulate susceptibility to cardiovascular seasonality...
May 18, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28492288/epidemiology-of-heart-failure-with-preserved-ejection-fraction
#16
REVIEW
Shannon M Dunlay, Véronique L Roger, Margaret M Redfield
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome associated with poor quality of life, substantial health-care resource utilization, and premature mortality. We summarize the current knowledge regarding the epidemiology of HFpEF with a focus on community-based studies relevant to quantifying the population burden of HFpEF. Current data regarding the prevalence and incidence of HFpEF in the community as well as associated conditions and risk factors, risk of morbidity and mortality after diagnosis, and quality of life are presented...
May 11, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28492286/has-the-sprint-trial-introduced-a-new-blood-pressure-goal-in-hypertension
#17
REVIEW
Gema Ruiz-Hurtado, José R Banegas, Pantelis A Sarafidis, Massimo Volpe, Bryan Williams, Luis M Ruilope
SPRINT is the first randomized, controlled trial showing that a systolic blood-pressure goal of <120 mmHg can be attained with cardiovascular benefits in a select group of patients with hypertension and an elevated cardiovascular risk with different origins. Although the patient population with characteristics like those in SPRINT makes up only 20-30% of the total hypertensive population, SPRINT is a landmark study that highlights the need to consider lower blood- pressure goals in the treatment of hypertension...
May 11, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28470179/autoimmune-channelopathies-as-a-novel-mechanism-in-cardiac-arrhythmias
#18
REVIEW
Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Franco Laghi-Pasini, Mohamed Boutjdir
Cardiac arrhythmias confer a considerable burden of morbidity and mortality in industrialized countries. Although coronary artery disease and heart failure are the prevalent causes of cardiac arrest, in 5-15% of patients, structural abnormalities at autopsy are absent. In a proportion of these patients, mutations in genes encoding cardiac ion channels are documented (inherited channelopathies), but, to date, the molecular autopsy is negative in nearly 70% of patients. Emerging evidence indicates that autoimmunity is involved in the pathogenesis of cardiac arrhythmias...
May 4, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28682323/atherosclerosis-somatic-mutations-in-haematopoietic-cells-contribute-to-atherosclerosis
#19
Karina Huynh
No abstract text is available yet for this article.
August 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28682322/dyslipidaemia-anti-pcsk9-vaccines-to-halt-atherosclerosis
#20
Dario Ummarino
No abstract text is available yet for this article.
August 2017: Nature Reviews. Cardiology
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