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Nature Reviews. Cardiology

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https://www.readbyqxmd.com/read/28230176/antithrombotic-therapy-for-patients-with-stemi-undergoing-primary-pci
#1
REVIEW
Francesco Franchi, Fabiana Rollini, Dominick J Angiolillo
Antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Intravenous anticoagulant drugs available for PPCI include the indirect thrombin inhibitors unfractionated heparin and low-molecular-weight heparin, and the direct thrombin inhibitor bivalirudin. Intravenous antiplatelet drugs mainly include glycoprotein IIb/IIIa inhibitors and the P2Y12-receptor inhibitor cangrelor...
February 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28230175/cardiovascular-disease-in-africa-epidemiological-profile-and-challenges
#2
REVIEW
Ashley K Keates, Ana O Mocumbi, Mpiko Ntsekhe, Karen Sliwa, Simon Stewart
From a global perspective, the large and diverse African population is disproportionately affected by cardiovascular disease (CVD). The historical balance between communicable and noncommunicable pathways to CVD in different African regions is dependent on external factors over the life course and at a societal level. The future risk of noncommunicable forms of CVD (predominantly driven by increased rates of hypertension, smoking, and obesity) is a growing public health concern. The incidence of previously rare forms of CVD such as coronary artery disease will increase, in concert with historically prevalent forms of disease, such as rheumatic heart disease, that are yet to be optimally prevented or treated...
February 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28202901/stem-cells-allogenic-mesenchymal-stem-cells-for-dilated-cardiomyopathy
#3
Karina Huynh
No abstract text is available yet for this article.
February 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28202900/cardiovascular-disease-prevention-lifestyle-attenuation-of-genetic-risk
#4
Benoit J Arsenault, Jean-Pierre Després
No abstract text is available yet for this article.
February 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28181585/single-or-dual-antiplatelet-therapy-after-pci
#5
REVIEW
Yosuke Miyazaki, Pannipa Suwannasom, Yohei Sotomi, Mohammad Abdelghani, Karthik Tummala, Yuki Katagiri, Taku Asano, Erhan Tenekecioglu, Yaping Zeng, Rafael Cavalcante, Carlos Collet, Yoshinobu Onuma, Patrick W Serruys
The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. At the time of the first-in-man implantation of the sirolimus DES in 1999, the protocol-defined dual antiplatelet therapy (DAPT) duration was only 2 months. Subsequently, DAPT duration was extended to 1 year on the basis of anecdotal historical data, and this practice was then incorporated into clinical guidelines. For >1 decade, trialists have sought to compare the safety and efficacy of abbreviated (<6 months) and prolonged (>12 months) DAPT regimens...
February 9, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150806/dyslipidaemia-small-triumph-for-fenofibrate-therapy-in-dyslipidaemia
#6
Robert S Rosenson
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150805/venous-thromboembolism-thromboprophylaxis-with-statins
#7
Gregory B Lim
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150804/extracellular-vesicles-in-coronary-artery-disease
#8
REVIEW
Chantal M Boulanger, Xavier Loyer, Pierre-Emmanuel Rautou, Nicolas Amabile
Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesicles as regulators of transfer of biological information, acting locally and remotely, is now acknowledged. Circulating vesicles released from platelets, erythrocytes, leukocytes, and endothelial cells contain potential valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease...
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150803/vascular-disease-cell-therapy-lowers-pad-amputation-risk
#9
Karina Huynh
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28150802/device-therapy-a-robotic-heart-sleeve-to-keep-the-beat
#10
Irene Fernández-Ruiz
No abstract text is available yet for this article.
February 2, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127033/advanced-imaging-in-valvular-heart-disease
#11
REVIEW
Jeroen J Bax, Victoria Delgado
Although echocardiography remains the mainstay imaging technique for the evaluation of patients with valvular heart disease (VHD), innovations in noninvasive imaging in the past few years have provided new insights into the pathophysiology and quantification of VHD, early detection of left ventricular (LV) dysfunction, and advanced prognostic assessment. The severity grading of valve dysfunction has been refined with the use of Doppler echocardiography, cardiac magnetic resonance (CMR), and CT imaging. LV ejection fraction remains an important criterion when deciding whether patients should be referred for surgery...
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127032/diabetes-diabetes-induced-microvascular-destabilization
#12
Karina Huynh
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127031/risk-factors-linking-stress-to-arterial-inflammation-and-vascular-events
#13
Gregory B Lim
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127030/acute-coronary-syndromes-microbial-dependent-tmao-as-a-prognostic-marker-in-acs
#14
Irene Fernández-Ruiz
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127029/shared-decision-making-in-hcm
#15
Barry J Maron, Rick A Nishimura, Martin S Maron
No abstract text is available yet for this article.
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28127028/natural-killer-t-cells-in-atherosclerosis
#16
REVIEW
Godfrey S Getz, Catherine A Reardon
Atherosclerosis is a chronic inflammatory disorder that develops in response to hyperlipidaemia. Cells from both the innate and adaptive immune systems contribute to the development of atherosclerotic lesions. The role of natural killer T (NKT) cells in response to microbial pathogens and inflammatory disorders such as atherosclerosis has received increasing attention in the past 10-15 years. Endogenous self-lipid antigens and exogenous lipid antigens, including those on microorganisms can activate NKT cells...
January 27, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102234/heart-failure-recombinant-neuregulin-for-hf-treatment
#17
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102233/arrhythmias-optogenetic-control-of-cardiac-rhythm
#18
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102232/aetiology-and-management-of-hereditary-aortopathy
#19
REVIEW
Aline Verstraeten, Ilse Luyckx, Bart Loeys
Aortic aneurysms are a major health problem because they account for 1-2% of all deaths in the Western population. Although abdominal aortic aneurysms (AAAs) are more prevalent than thoracic aortic aneurysms (TAAs), TAAs have been more exhaustively studied over the past 2 decades because they have a higher heritability and affect younger individuals. Gene identification in both syndromic and nonsyndromic TAA is proceeding at a rapid pace and has already pinpointed >20 genes associated with familial TAA risk...
January 19, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28102231/cell-therapy-autologous-cardiac-stem-cells-for-congenital-hf
#20
Dario Ummarino
No abstract text is available yet for this article.
January 19, 2017: Nature Reviews. Cardiology
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