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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/29995836/what-now-for-embolic-stroke-of-undetermined-source
#1
Didier Leys, Solène Moulin
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29995835/retinal-nerve-fibre-layer-thickness-a-biomarker-of-early-dementia
#2
Ian Fyfe
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29991822/microglia-show-sex-specific-gene-expression-profiles
#3
Heather Wood
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29991821/new-clues-to-the-genetic-links-between-ad-and-down-syndrome
#4
Charlotte Ridler
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29991820/risk-of-dementia-after-tbi-a-cause-of-growing-concern
#5
Cassandra L Pattinson, Jessica M Gill
No abstract text is available yet for this article.
July 10, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29985475/multidimensional-communication-in-the-microenvirons-of-glioblastoma
#6
REVIEW
Marike L Broekman, Sybren L N Maas, Erik R Abels, Thorsten R Mempel, Anna M Krichevsky, Xandra O Breakefield
Glioblastomas are heterogeneous and invariably lethal tumours. They are characterized by genetic and epigenetic variations among tumour cells, which makes the development of therapies that eradicate all tumour cells challenging and currently impossible. An important component of glioblastoma growth is communication with and manipulation of other cells in the brain environs, which supports tumour progression and resistance to therapy. Glioblastoma cells recruit innate immune cells and change their phenotype to support tumour growth...
July 9, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29985474/sex-differences-in-alzheimer-disease-the-gateway-to-precision-medicine
#7
REVIEW
Maria Teresa Ferretti, Maria Florencia Iulita, Enrica Cavedo, Patrizia Andrea Chiesa, Annemarie Schumacher Dimech, Antonella Santuccione Chadha, Francesca Baracchi, Hélène Girouard, Sabina Misoch, Ezio Giacobini, Herman Depypere, Harald Hampel
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic variation will be crucial for the development of precise and effective therapeutics in AD. Sex-related differences in neural anatomy and function are starting to emerge, and sex might constitute an important factor for AD patient stratification and personalized treatment. Although the effects of sex on AD epidemiology are currently the subject of intense investigation, the notion of sex-specific clinicopathological AD phenotypes is largely unexplored...
July 9, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29980763/spatial-navigation-deficits-overlooked-cognitive-marker-for-preclinical-alzheimer-disease
#8
REVIEW
Gillian Coughlan, Jan Laczó, Jakub Hort, Anne-Marie Minihane, Michael Hornberger
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals...
July 6, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29967362/why-dystrophin-quantification-is-key-in-the-eteplirsen-saga
#9
Annemieke Aartsma-Rus, Virginia Arechavala-Gomeza
No abstract text is available yet for this article.
July 2, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29959394/nrem-sleep-parasomnias-as-disorders-of-sleep-state-dissociation
#10
REVIEW
Anna Castelnovo, Régis Lopez, Paola Proserpio, Lino Nobili, Yves Dauvilliers
Non-rapid eye movement (NREM) sleep parasomnias (or NREM parasomnias) are fascinating disorders with mysterious neurobiological substrates. These conditions are common and often severe, with social, personal and forensic implications. The NREM parasomnias include sleepwalking, sleep terrors and confusional arousals - collectively termed disorders of arousal (DOAs) - as well as less well-known entities such as sleep-related sexual behaviours and eating disorders. Affected patients can exhibit waking behaviours arising abruptly out of NREM sleep...
June 29, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29959393/the-struggle-for-stroke-reclassification
#11
Raad Shakir
No abstract text is available yet for this article.
June 29, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29946076/new-glioblastoma-heterogeneity-atlas-a-shared-resource
#12
Wolfgang Wick, Tobias Kessler
No abstract text is available yet for this article.
June 26, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29941994/new-drug-blocks-brain-metastasis
#13
Charlotte Ridler
No abstract text is available yet for this article.
June 25, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29934584/exosomes-can-spread-toxic-ad-pathology
#14
Ian Fyfe
No abstract text is available yet for this article.
June 22, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29930323/targeting-tnf-to-alleviate-zika-virus-complications
#15
Heather Wood
No abstract text is available yet for this article.
June 21, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29925925/promises-and-limitations-of-immune-cell-based-therapies-in-neurological-disorders
#16
REVIEW
Xiaoming Hu, Rehana K Leak, Angus W Thomson, Fang Yu, Yuguo Xia, Lawrence R Wechsler, Jun Chen
The healthy immune system has natural checkpoints that temper pernicious inflammation. Cells mediating these checkpoints include regulatory T cells, regulatory B cells, regulatory dendritic cells, microglia, macrophages and monocytes. Here, we highlight discoveries on the beneficial functions of regulatory immune cells and their mechanisms of action and evaluate their potential use as novel cell-based therapies for brain disorders. Regulatory immune cell therapies have the potential not only to mitigate the exacerbation of brain injury by inflammation but also to promote an active post-injury brain repair programme...
June 20, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29925924/neuroimmune-disorders-of-the-central-nervous-system-in-children-in-the-molecular-era
#17
REVIEW
Elizabeth Wells, Yael Hacohen, Amy Waldman, Jan M Tillema, Ariane Soldatos, Beau Ances, Susanne Benseler, Bibi Bielekova, Russel C Dale, Josep Dalmau, William Gaillard, Mark Gorman, Benjamin Greenberg, Ann Hyslop, Carlos A Pardo, Robert C Tasker, E Ann Yeh, Amit Bar-Or, Sean Pittock, Adeline Vanderver, Brenda Banwell
Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development...
June 20, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29925923/haemoglobin-scavenging-in-intracranial-bleeding-biology-and-clinical-implications
#18
REVIEW
Diederik Bulters, Ben Gaastra, Ardalan Zolnourian, Sheila Alexander, Dianxu Ren, Spiros L Blackburn, Mark Borsody, Sylvain Doré, James Galea, Koji Iihara, Paul Nyquist, Ian Galea
Haemoglobin is released into the CNS during the breakdown of red blood cells after intracranial bleeding. Extracellular free haemoglobin is directly neurotoxic. Haemoglobin scavenging mechanisms clear haemoglobin and reduce toxicity; these mechanisms include erythrophagocytosis, haptoglobin binding of haemoglobin, haemopexin binding of haem and haem oxygenase breakdown of haem. However, the capacity of these mechanisms is limited in the CNS, and they easily become overwhelmed. Targeting of haemoglobin toxicity and scavenging is, therefore, a rational therapeutic strategy...
June 20, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29915370/apoe4-transforms-the-transcriptome
#19
Charlotte Ridler
No abstract text is available yet for this article.
June 18, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29895964/tau-targeting-therapies-for-alzheimer-disease
#20
REVIEW
Erin E Congdon, Einar M Sigurdsson
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated loss of synapses and neurons, resulting in cognitive deficits and eventually dementia. Amyloid-β (Aβ) peptide and tau protein are the primary components of the plaques and tangles, respectively. In the decades since Aβ and tau were identified, development of therapies for AD has primarily focused on Aβ, but tau has received more attention in recent years, in part because of the failure of various Aβ-targeting treatments in clinical trials...
June 12, 2018: Nature Reviews. Neurology
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