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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/28084327/treatment-decisions-in-multiple-sclerosis-insights-from-real-world-observational-studies
#1
REVIEW
Maria Trojano, Mar Tintore, Xavier Montalban, Jan Hillert, Tomas Kalincik, Pietro Iaffaldano, Tim Spelman, Maria Pia Sormani, Helmut Butzkueven
The complexity of multiple sclerosis (MS) treatment means that doctors and decision-makers need the best available evidence to make the best decisions for patient care. Randomized controlled trials (RCTs) are accepted as the gold standard for assessing the efficacy and safety of any new drug, but conclusions of these trials do not always aid in daily decision-making processes. Indeed, RCTs are usually conducted in ideal conditions, so can measure efficacy only in restricted and unrepresentative populations...
January 13, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28009016/motor-neuron-disease-nusinersen-potentially-effective-in-sma
#2
Louise Adams
No abstract text is available yet for this article.
December 23, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28009015/neuroimmunology-could-antibodies-cause-psychosis
#3
Ian Fyfe
No abstract text is available yet for this article.
December 23, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27982042/parkinson-disease-could-gut-microbiota-influence-severity-of-parkinson-disease
#4
Hemi Malkki
No abstract text is available yet for this article.
December 16, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27982040/gene-discovery-in-amyotrophic-lateral-sclerosis-implications-for-clinical-management
#5
REVIEW
Ammar Al-Chalabi, Leonard H van den Berg, Jan Veldink
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. The disease leads to relentlessly progressive weakness of voluntary muscles, with death typically resulting from diaphragmatic failure within 2-5 years. Since the discovery of mutations in SOD1, which account for ∼2% of ALS cases, increasing efforts have been made to understand the genetic component of ALS risk, with the expectation that this insight will not only aid diagnosis and classification, but also guide personalized treatment and reveal the mechanisms that cause motor neuron death...
December 16, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27857123/low-grade-epilepsy-associated-neuroepithelial-tumours-the-2016-who-classification
#6
REVIEW
Ingmar Blümcke, Eleonora Aronica, Albert Becker, David Capper, Roland Coras, Mrinalini Honavar, Thomas S Jacques, Katja Kobow, Hajime Miyata, Angelika Mühlebner, José Pimentel, Figen Söylemezoğlu, Maria Thom
Rapid developments in molecular genetic technology and research have swiftly advanced our understanding of neuro-oncology. As a consequence, the WHO invited their expert panels to revise the current classification system of brain tumours and to introduce, for the first time, a molecular genetic approach for selected tumour entities, thus setting a new gold standard in histopathology. The revised 5th edition of the 'blue book' was released in May 2016 and will have a major impact in stratifying diagnosis and treatment...
November 18, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27857122/eteplirsen-therapy-for-duchenne-muscular-dystrophy-skipping-to-the-front-of-the-line
#7
James J Dowling
No abstract text is available yet for this article.
November 18, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27857121/guillain-barr%C3%A3-syndrome-a-century-of-progress
#8
REVIEW
John A Goodfellow, Hugh J Willison
In 1916, Guillain, Barré and Strohl reported on two cases of acute flaccid paralysis with high cerebrospinal fluid protein levels and normal cell counts - novel findings that identified the disease we now know as Guillain-Barré syndrome (GBS). 100 years on, we have made great progress with the clinical and pathological characterization of GBS. Early clinicopathological and animal studies indicated that GBS was an immune-mediated demyelinating disorder, and that severe GBS could result in secondary axonal injury; the current treatments of plasma exchange and intravenous immunoglobulin, which were developed in the 1980s, are based on this premise...
November 18, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27834395/cns-infections-a-new-herpes-zoster-subunit-vaccine-for-older-adults
#9
Charlotte Warren-Gash, Judith Breuer
No abstract text is available yet for this article.
November 11, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27834394/the-central-vein-sign-and-its-clinical-evaluation-for-the-diagnosis-of-multiple-sclerosis-a-consensus-statement-from-the-north-american-imaging-in-multiple-sclerosis-cooperative
#10
Pascal Sati, Jiwon Oh, R Todd Constable, Nikos Evangelou, Charles R G Guttmann, Roland G Henry, Eric C Klawiter, Caterina Mainero, Luca Massacesi, Henry McFarland, Flavia Nelson, Daniel Ontaneda, Alexander Rauscher, William D Rooney, Amal P R Samaraweera, Russell T Shinohara, Raymond A Sobel, Andrew J Solomon, Constantina A Treaba, Jens Wuerfel, Robert Zivadinov, Nancy L Sicotte, Daniel Pelletier, Daniel S Reich
Over the past few years, MRI has become an indispensable tool for diagnosing multiple sclerosis (MS). However, the current MRI criteria for MS diagnosis have imperfect sensitivity and specificity. The central vein sign (CVS) has recently been proposed as a novel MRI biomarker to improve the accuracy and speed of MS diagnosis. Evidence indicates that the presence of the CVS in individual lesions can accurately differentiate MS from other diseases that mimic this condition. However, the predictive value of the CVS for the development of clinical MS in patients with suspected demyelinating disease is still unknown...
November 11, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27834393/neurodegenerative-disease-new-in-vivo-evidence-that-different-tau-strains-cause-different-diseases
#11
Ian Fyfe
No abstract text is available yet for this article.
November 11, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27811919/cerebrovascular-disorders-exercise-alleviates-vascular-cognitive-impairment
#12
Hemi Malkki
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27811918/multiple-sclerosis-coagulation-factors-could-mediate-neuroinflammation-in-multiple-sclerosis
#13
Hemi Malkki
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27811917/neuro-oncology-met-fusion-genes-implicated-as-treatment-target-in-paediatric-glioblastoma
#14
Hemi Malkki
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27811916/movement-disorders-novel-genetic-risk-variants-for-essential-tremor
#15
Hemi Malkki
No abstract text is available yet for this article.
November 4, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27808265/unruptured-intracranial-aneurysms-development-rupture-and-preventive-management
#16
REVIEW
Nima Etminan, Gabriel J Rinkel
Saccular unruptured intracranial aneurysms (UIAs) have a prevalence of 3% in the adult population, and are being increasingly detected because of improved quality and higher frequency of cranial imaging. Large amounts of data, providing varying levels of evidence, have been published on aneurysm development, progression and rupture, but less information is available on the risks and efficacy of preventive treatment. When deciding how to best manage UIAs, clinicians must consider the age and life expectancy of the patient, the estimated risk of rupture, the risk of complications attributed to preventive treatment, and the level of anxiety caused by the awareness of having an aneurysm...
November 3, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27982044/clinical-trials-to-catch-a-crook-you-might-try-statistics
#17
Gary R Cutter
No abstract text is available yet for this article.
January 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27982043/gene-therapy-gene-editing-therapy-for-neurological-disease
#18
Moira A McMahon, Don W Cleveland
No abstract text is available yet for this article.
January 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27982041/mechanisms-of-radiotherapy-associated-cognitive-disability-in-patients-with-brain-tumours
#19
REVIEW
Milan T Makale, Carrie R McDonald, Jona A Hattangadi-Gluth, Santosh Kesari
Standard treatment of primary and metastatic brain tumours includes high-dose megavoltage-range radiation to the cranial vault. About half of patients survive >6 months, and many attain long-term control or cure. However, 50-90% of survivors exhibit disabling cognitive dysfunction. The radiation-associated cognitive syndrome is poorly understood and has no effective prevention or long-term treatment. Attention has primarily focused on mechanisms of disability that appear at 6 months to 1 year after radiotherapy...
January 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27934855/alzheimer-disease-sex-specific-inflammatory-link-to-early-alzheimer-pathology
#20
Ian Fyfe
No abstract text is available yet for this article.
January 2017: Nature Reviews. Neurology
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