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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/28524175/modulators-of-microglial-activation-and-polarization-after-intracerebral-haemorrhage
#1
REVIEW
Xi Lan, Xiaoning Han, Qian Li, Qing-Wu Yang, Jian Wang
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks effective treatment. Microglia are among the first non-neuronal cells on the scene during the innate immune response to ICH. Microglia respond to acute brain injury by becoming activated and developing classic M1-like (proinflammatory) or alternative M2-like (anti-inflammatory) phenotypes. This polarization implies as yet unrecognized actions of microglia in ICH pathology and recovery, perhaps involving microglial production of proinflammatory or anti-inflammatory cytokines and chemokines...
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28524174/dementia-imaging-signatures-identified-for-dementia-subtypes
#2
Ian Fyfe
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28524173/dementia-multimodal-dementia-prevention-does-trial-design-mask-efficacy
#3
Nikolaos Scarmeas
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28524172/in-the-news-clinical-trials-excite-at-aan-2017
#4
Charlotte Ridler
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28497806/management-of-diffuse-low-grade-gliomas-in-adults-use-of-molecular-diagnostics
#5
REVIEW
Jan Buckner, Caterina Giannini, Jeanette Eckel-Passow, Daniel Lachance, Ian Parney, Nadia Laack, Robert Jenkins
Diffuse WHO grade II gliomas are histologically and genetically heterogeneous. The 2016 WHO classification redefines grade II gliomas with respect to morphological and molecular tumour alterations: grade II oligodendrogliomas are defined by the presence of whole-arm codeletion in chromosomal arms 1p/19q, whereas isocitrate dehydrogenase (IDH) mutations define subclasses of astrocytoma. Although histological grade remains useful, the prognoses of patients with glioma are more tightly associated with molecular alterations than with grade, and chromosomal and gene array technologies are becoming increasingly beneficial in understanding tumour genetic heterogeneity...
May 12, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28497805/the-changing-prevalence-and-incidence-of-dementia-over-time-current-evidence
#6
REVIEW
Yu-Tzu Wu, Alexa S Beiser, Monique M B Breteler, Laura Fratiglioni, Catherine Helmer, Hugh C Hendrie, Hiroyuki Honda, M Arfan Ikram, Kenneth M Langa, Antonio Lobo, Fiona E Matthews, Tomoyuki Ohara, Karine Pérès, Chengxuan Qiu, Sudha Seshadri, Britt-Marie Sjölund, Ingmar Skoog, Carol Brayne
Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and incidence are changing over time. To establish clear trends, such comparisons need to be founded on population-based studies that use similar diagnostic and research methods consistently over time. This narrative Review synthesizes the findings from 14 studies that investigated trends in dementia prevalence (nine studies) and incidence (five studies) from Sweden, Spain, the UK, the Netherlands, France, the USA, Japan and Nigeria...
May 12, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28497804/vaccine-based-immunotherapeutic-approaches-to-gliomas-and-beyond
#7
REVIEW
Michael Weller, Patrick Roth, Matthias Preusser, Wolfgang Wick, David A Reardon, Michael Platten, John H Sampson
Astrocytic and oligodendroglial gliomas are intrinsic brain tumours characterized by infiltrative growth and resistance to classic cancer therapies, which renders them inevitably lethal. Glioblastoma, the most common type of glioma, also exhibits neoangiogenesis and profound immunosuppressive properties. Accordingly, strategies to revert glioma-associated immunosuppression and promote tumour-directed immune responses have been extensively explored in rodent models and in large clinical trials of tumour immunotherapy...
May 12, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28497803/motor-neuron-disease-proinflammatory-monocytes-might-contribute-to-als-progression
#8
Ian Fyfe
No abstract text is available yet for this article.
May 12, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28474684/neurodegenerative-disease-halting-neurodegeneration-are-repurposed-drugs-the-answer
#9
Heather Wood
No abstract text is available yet for this article.
May 5, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28474683/epilepsy-new-classification-of-seizures-and-epilepsies-an-advance
#10
Ettore Beghi
No abstract text is available yet for this article.
May 5, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28452354/stroke-cortical-superficial-siderosis-absent-in-cadasil
#11
Charlotte Ridler
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28452353/alzheimer-disease-a-quantitative-trait-approach-to-gwas-pays-dividends
#12
Liana G Apostolova
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28452352/parkinson-disease-antibodies-reveal-age-of-lewy-pathology-in-pd
#13
Heather Wood
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28452351/motor-neuron-disease-detection-of-glycine-proline-repeat-protein-offers-new-biomarker-in-patients-with-c9orf72-expansion
#14
Charlotte Ridler
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28452350/multiple-sclerosis-perinatal-risk-factors-for-paediatric-ms
#15
Charlotte Ridler
No abstract text is available yet for this article.
April 28, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28429803/observational-studies-and-the-chicken-and-egg-issue-in-stroke
#16
Tara Purvis, Dominique A Cadilhac
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28429802/parkinson-disease-in-situ-astrocyte-reprogramming-simpler-cell-replacement-therapy-in-pd
#17
Ian Fyfe
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28429801/the-dizzy-patient-don-t-forget-disorders-of-the-central-vestibular-system
#18
REVIEW
Thomas Brandt, Marianne Dieterich
Vertigo and dizziness are among the most common complaints in neurology clinics, and they account for about 13% of the patients entering emergency units. In this Review, we focus on central vestibular disorders, which are mostly attributable to acute unilateral lesions of the bilateral vestibular circuitry in the brain. In a tertiary interdisciplinary outpatient dizziness unit, central vestibular disorders, including vestibular migraine, comprise about 25% of the established diagnoses. The signs and symptoms of these disorders can mimic those of peripheral vestibular disorders with sustained rotational vertigo...
April 21, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28418025/cerebrovascular-disease-cead-and-migraine-an-association-built-on-shifting-sands
#19
Caspar Grond-Ginsbach, Manja Kloss
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28418024/alzheimer-disease-neurofilament-light-in-the-blood-marks-alzheimer-degeneration
#20
Ian Fyfe
No abstract text is available yet for this article.
April 18, 2017: Nature Reviews. Neurology
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