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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/29146955/motor-neuron-disease-positive-trial-results-published-for-ground-breaking-sma-therapies
#1
Charlotte Ridler
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146954/multiple-sclerosis-progressive-multifocal-leukoencephalopathy-risk-stratification
#2
Kalliopi Pitarokoili, Ralf Gold
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146953/achievements-and-obstacles-of-remyelinating-therapies-in-multiple-sclerosis
#3
REVIEW
Martin Stangel, Tanja Kuhlmann, Paul M Matthews, Trevor J Kilpatrick
Remyelination in the CNS is the natural process of damage repair in demyelinating diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in many people with MS, which results in axonal degeneration and clinical disability. Enhancement of remyelination is a logical therapeutic goal; nevertheless, all currently licensed therapies for MS are immunomodulatory and do not support remyelination directly. Several molecular pathways have been identified as potential therapeutic targets to induce remyelination, and some of these have now been assessed in proof-of-concept clinical trials...
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146952/migrainomics-identifying-brain-and-genetic-markers-of-migraine
#4
REVIEW
Dale R Nyholt, David Borsook, Lyn R Griffiths
Migraine is one of the world's most prevalent and disabling disorders and imposes an enormous socioeconomic burden. The exact causes of migraine are unknown, and no recognizable diagnostic pathological changes have been identified. Specific identifiable markers of migraine would aid diagnosis and could provide insight into the pathogenesis of the condition, with the potential to direct development of new therapeutics. In the past few years, advances in neuroimaging and genetic studies have provided the most substantial progress towards the identification of markers...
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146951/alzheimer-disease-blood-derived-a%C3%AE-induces-ad-pathology
#5
Shimona Starling
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29123251/alzheimer-disease-pink1-rescues-pathology-in-alzheimer-disease
#6
Shimona Starling
No abstract text is available yet for this article.
November 10, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29123250/parkinson-disease-what-goes-around-comes-around-cognitive-impairment-as-prodromal-parkinsonism
#7
Yaroslau Compta, Maria J Martí
No abstract text is available yet for this article.
November 10, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29104291/a-unifying-motor-control-framework-for-task-specific-dystonia
#8
REVIEW
Anna Sadnicka, Katja Kornysheva, John C Rothwell, Mark J Edwards
Task-specific dystonia is a movement disorder characterized by a painless loss of dexterity specific to a particular motor skill. This disorder is prevalent among writers, musicians, dancers and athletes. No current treatment is predictably effective, and the disorder generally ends the careers of affected individuals. Traditional disease models of dystonia have a number of limitations with regard to task-specific dystonia. We therefore discuss emerging evidence that the disorder has its origins within normal compensatory mechanisms of a healthy motor system in which the representation and reproduction of motor skill are disrupted...
November 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29104290/alzheimer-disease-is-p-tau-the-missing-link-between-insulin-resistance-and-ad
#9
Heather Wood
No abstract text is available yet for this article.
November 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29104289/inflammatory-cns-disease-caused-by-immune-checkpoint-inhibitors-status-and-perspectives
#10
REVIEW
Lidia M Yshii, Reinhard Hohlfeld, Roland S Liblau
Cancer treatment strategies based on immune stimulation have recently entered the clinical arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by indiscriminately promoting immune responses, which target tumour-associated antigens or tumour-specific mutations. However, the augmented immune response, most notably the T cell response, can cause either direct neurotoxicity or, more commonly, indirect neurotoxic effects through systemic or local inflammatory mechanisms or autoimmune mechanisms...
November 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29075037/neurodevelopmental-disorders-miniaturized-protein-offers-treatment-hopes-for-rett-syndrome
#11
Charlotte Ridler
No abstract text is available yet for this article.
October 27, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29064470/neurometabolic-disease-gene-therapy-success-for-cerebral-adrenoleukodystrophy
#12
Charlotte Ridler
No abstract text is available yet for this article.
October 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29064469/movement-disorders-patients-with-spinocerebellar-ataxia-38-benefit-from-dha-supplementation
#13
Heather Wood
No abstract text is available yet for this article.
October 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29064468/neuromuscular-disease-tadalafil-fails-to-halt-the-progression-of-duchenne-muscular-dystrophy
#14
Heather Wood
No abstract text is available yet for this article.
October 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29064467/parkinson-disease-caffeine-and-nicotine-do-not-provide-symptomatic-relief-in-parkinson-disease
#15
Heather Wood
No abstract text is available yet for this article.
October 23, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29027543/motor-neuron-disease-peripheral-immune-cell-levels-correlate-with-disease-progression-in-als
#16
Peter Sidaway
No abstract text is available yet for this article.
October 13, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28984314/alzheimer-disease-apoe4-implicated-in-tau-mediated-neurodegeneration
#17
Heather Wood
No abstract text is available yet for this article.
October 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28984313/human-models-of-migraine-short-term-pain-for-long-term-gain
#18
REVIEW
Messoud Ashina, Jakob Møller Hansen, Bára Oladóttir Á Dunga, Jes Olesen
Migraine is a complex disorder characterized by recurrent episodes of headache, and is one of the most prevalent and disabling neurological disorders. A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks. In this Review, we summarize the existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling...
October 6, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28960186/multiple-sclerosis-a-possible-link-between-multiple-sclerosis-and-gut-microbiota
#19
Jordan Hindson
No abstract text is available yet for this article.
September 29, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28884753/cladribine-an-old-newcomer-for-pulsed-immune-reconstitution-in-ms
#20
Heinz Wiendl
The EMA has approved cladribine tablets for the treatment of multiple sclerosis. The drug is not new, and the journey to its approval has been a long one, but the old concepts that cladribine therapy are based on provide a new option for the possibility of drug-free remission.
September 8, 2017: Nature Reviews. Neurology
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