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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/29326425/unified-understanding-of-ms-course-is-required-for-drug-development
#1
Timothy Coetzee, Alan J Thompson
No abstract text is available yet for this article.
January 12, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29326424/assessing-treatment-outcomes-in-multiple-sclerosis-trials-and-in-the-clinical-setting
#2
REVIEW
Carmen Tur, Marcello Moccia, Frederik Barkhof, Jeremy Chataway, Jaume Sastre-Garriga, Alan J Thompson, Olga Ciccarelli
Increasing numbers of drugs are being developed for the treatment of multiple sclerosis (MS). Measurement of relevant outcomes is key for assessing the efficacy of new drugs in clinical trials and for monitoring responses to disease-modifying drugs in individual patients. Most outcomes used in trial and clinical settings reflect either clinical or neuroimaging aspects of MS (such as relapse and accrual of disability or the presence of visible inflammation and brain tissue loss, respectively). However, most measures employed in clinical trials to assess treatment effects are not used in routine practice...
January 12, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29326423/peripheral-neuropathies-subcutaneous-immunoglobulin-the-future-of-cidp-treatment
#3
Benjamin R Wakerley, Nobuhiro Yuki
No abstract text is available yet for this article.
January 12, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29302065/adulthood-leukodystrophies
#4
REVIEW
Wolfgang Köhler, Julian Curiel, Adeline Vanderver
The leukodystrophies are a group of inherited white matter disorders with a heterogeneous genetic background, considerable phenotypic variability and disease onset at all ages. This Review focuses on leukodystrophies with major prevalence or primary onset in adulthood. We summarize 20 leukodystrophies with adult presentations, providing information on the underlying genetic mutations and on biochemical assays that aid diagnosis, where available. Definitions, clinical characteristics, age of onset, MRI findings and treatment options are all described, providing a comprehensive overview of the current knowledge of the various adulthood leukodystrophies...
January 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29302064/advances-in-meningioma-genetics-novel-therapeutic-opportunities
#5
REVIEW
Matthias Preusser, Priscilla K Brastianos, Christian Mawrin
Meningiomas currently are among the most frequent intracranial tumours. Although the majority of meningiomas can be cured by surgical resection, ∼20% of patients have an aggressive clinical course with tumour recurrence or progressive disease, resulting in substantial morbidity and increased mortality of affected patients. During the past 3 years, exciting new data have been published that provide insights into the molecular background of meningiomas and link sites of tumour development with characteristic histopathological and molecular features, opening a new road to novel and promising treatment options for aggressive meningiomas...
January 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29302063/multiple-sclerosis-extracranial-venous-angioplasty-is-ineffective-to-treat-ms
#6
Robert Zivadinov, Bianca Weinstock-Guttman
No abstract text is available yet for this article.
January 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29302062/parkinson-disease-in-2017-changing-views-after-200-years-of-parkinson-disease
#7
Walter Maetzler, Daniela Berg
No abstract text is available yet for this article.
January 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29269786/peripheral-neuropathies-antisense-therapy-for-charcot-marie-tooth-disease
#8
Charlotte Ridler
No abstract text is available yet for this article.
December 22, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29269785/ageing-somatic-mutations-accumulate-in-ageing-and-diseased-neurons
#9
Shimona Starling
No abstract text is available yet for this article.
December 22, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29242523/migraine-cgrp-targeting-antibodies-reduce-migraine-frequency
#10
Heather Wood
No abstract text is available yet for this article.
December 15, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29217826/parkinson-s-disease-the-story-of-an-eponym
#11
REVIEW
Michel Goedert, Alastair Compston
One of the most prevalent neurodegenerative diseases worldwide is still referred to as 'Parkinson's disease'. The condition is named after James Parkinson who, in 1817, described the shaking palsy (paralysis agitans). In the bicentennial year of this publication, we trace when and why the shaking palsy became Parkinson's disease. The term was coined by William Rutherford Sanders of Edinburgh in 1865 and later entered general usage through the influence of Jean-Martin Charcot and the school that he nurtured at the Salpêtrière Hospital in Paris...
December 8, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29217825/prion-disease-skin-is-a-source-of-infectious-prions-in-scjd
#12
Shimona Starling
No abstract text is available yet for this article.
December 8, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29192262/parkinson-disease-lysosome-storage-disorder-risk-genes-linked-to-pd
#13
Charlotte Ridler
No abstract text is available yet for this article.
December 1, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29192261/parkinson-disease-blood-transcriptomics-for-parkinson-disease
#14
Alice S Chen-Plotkin
No abstract text is available yet for this article.
December 1, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29192259/cns-infections-zika-virus-mutation-associated-with-increased-infectivity-mortality-and-severe-microcephaly
#15
Charlotte Ridler
No abstract text is available yet for this article.
December 1, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29192257/stroke-brain-health-what-is-it-what-can-we-do-about-it-and-when-should-we-start
#16
Charles DeCarli
No abstract text is available yet for this article.
December 1, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29170502/multiple-sclerosis-10-year-study-shines-a-light-on-grey-matter-atrophy-in-ms
#17
Heather Wood
No abstract text is available yet for this article.
November 24, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29170501/idiopathic-rem-sleep-behaviour-disorder-and-neurodegeneration-an-update
#18
REVIEW
Birgit Högl, Ambra Stefani, Aleksandar Videnovic
So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly seen as a rare parasomnia, is now recognized as the prodromal stage of an α-synucleinopathy. Given the very high risk that patients with idiopathic RBD have of developing α-synucleinopathies, such as Parkinson disease (PD), PD dementia, dementia with Lewy bodies or multiple system atrophy, and the outstandingly high specificity and very long interval between the onset of idiopathic RBD and the clinical manifestations of α-synucleinopathies, the prodromal phase of this disorder represents a unique opportunity for potentially disease-modifying intervention...
November 24, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29170500/white-matter-disease-targeted-aspartoacylase-gene-therapy-reverts-canavan-disease
#19
Shimona Starling
No abstract text is available yet for this article.
November 24, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29146955/motor-neuron-disease-positive-trial-results-published-for-ground-breaking-sma-therapies
#20
Charlotte Ridler
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Neurology
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