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Nature Reviews. Neurology

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https://www.readbyqxmd.com/read/30214047/therapeutic-potential-for-peripheral-clearance-of-misfolded-brain-proteins
#1
Mony J de Leon, Kaj Blennow
No abstract text is available yet for this article.
September 13, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30214046/alcohol-and-dementia-risk-or-protective-factor
#2
Kaarin J Anstey, Ruth Peters
No abstract text is available yet for this article.
September 13, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30206321/huntington-disease-a-neurodevelopmental-disorder
#3
Heather Wood
No abstract text is available yet for this article.
September 11, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30181546/a-new-subtype-of-multiple-sclerosis
#4
Ian Fyfe
No abstract text is available yet for this article.
September 4, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30171200/neurofilaments-as-biomarkers-in-neurological-disorders
#5
REVIEW
Michael Khalil, Charlotte E Teunissen, Markus Otto, Fredrik Piehl, Maria Pia Sormani, Thomas Gattringer, Christian Barro, Ludwig Kappos, Manuel Comabella, Franz Fazekas, Axel Petzold, Kaj Blennow, Henrik Zetterberg, Jens Kuhle
Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate neuroaxonal injury independent of causal pathways...
August 31, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30166601/artificial-intelligence-accelerates-detection-of-neurological-illness
#6
Charlotte Ridler
No abstract text is available yet for this article.
August 30, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30158561/a-potential-biomarker-strategy-to-monitor-treatment-response-in-spinal-muscular-atrophy
#7
Heather Wood
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30158560/addition-of-bevacizumab-fails-to-improve-on-temozolomide-alone-for-glioma-therapy
#8
Heather Wood
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30158559/fda-approves-patisiran-to-treat-hereditary-transthyretin-amyloidosis
#9
Heather Wood
No abstract text is available yet for this article.
August 29, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30143795/evidence-mounts-for-anti-cgrp-treatment-in-cluster-headache
#10
Massimo Leone
No abstract text is available yet for this article.
August 24, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30143794/lafora-disease-from-pathogenesis-to-treatment-strategies
#11
REVIEW
Felix Nitschke, Saija J Ahonen, Silvia Nitschke, Sharmistha Mitra, Berge A Minassian
Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy. The disease usually manifests in previously healthy adolescents, and death commonly occurs within 10 years of symptom onset. Lafora disease is caused by loss-of-function mutations in EPM2A or NHLRC1, which encode laforin and malin, respectively. The absence of either protein results in poorly branched, hyperphosphorylated glycogen, which precipitates, aggregates and accumulates into Lafora bodies. Evidence from Lafora disease genetic mouse models indicates that these intracellular inclusions are a principal driver of neurodegeneration and neurological disease...
August 24, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30131521/seizure-prediction-ready-for-a-new-era
#12
REVIEW
Levin Kuhlmann, Klaus Lehnertz, Mark P Richardson, Björn Schelter, Hitten P Zaveri
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming majority of people with epilepsy regard the unpredictability of seizures as a major issue. More than 30 years of international effort have been devoted to the prediction of seizures, aiming to remove the burden of unpredictability and to couple novel, time-specific treatment to seizure prediction technology. A highly influential review published in 2007 concluded that insufficient evidence indicated that seizures could be predicted...
August 21, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30131520/spinocerebellar-ataxias-prospects-and-challenges-for-therapy-development
#13
REVIEW
Tetsuo Ashizawa, Gülin Öz, Henry L Paulson
The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant neurodegenerative disorders that present principally with progressive ataxia. Within the past few years, studies of pathogenic mechanisms in the SCAs have led to the development of promising therapeutic strategies, especially for SCAs caused by polyglutamine-coding CAG repeats. Nucleotide-based gene-silencing approaches that target the first steps in the pathogenic cascade are one promising approach not only for polyglutamine SCAs but also for the many other SCAs caused by toxic mutant proteins or RNA...
August 21, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30120349/apoe-%C3%AE%C2%B54-a-risk-factor-for-tdp43-pathology
#14
Ian Fyfe
No abstract text is available yet for this article.
August 17, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30104746/traumatic-brain-injury-induces-transmissible-tau-pathology
#15
Heather Wood
No abstract text is available yet for this article.
August 13, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30104745/multimodal-imaging-in-rbd-present-and-future
#16
Bradley F Boeve, Kejal Kantarci
No abstract text is available yet for this article.
August 13, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30093688/does-tau-pathology-activate-jumping-genes
#17
Charlotte Ridler
No abstract text is available yet for this article.
August 9, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30054555/patent-foramen-ovale-increases-stroke-risk-in-older-people
#18
Heinrich P Mattle, Jeffrey L Saver
No abstract text is available yet for this article.
July 27, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/30050128/microrna-from-dying-neurons-triggers-astrocytosis-in-als
#19
Charlotte Ridler
No abstract text is available yet for this article.
July 26, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29995836/what-now-for-embolic-stroke-of-undetermined-source
#20
Didier Leys, Solène Moulin
No abstract text is available yet for this article.
July 11, 2018: Nature Reviews. Neurology
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