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Nature Chemistry

Henry D Herce, Dominik Schumacher, Anselm F L Schneider, Anne K Ludwig, Florian A Mann, Marion Fillies, Marc-André Kasper, Stefan Reinke, Eberhard Krause, Heinrich Leonhardt, M Cristina Cardoso, Christian P R Hackenberger
Functional antibody delivery in living cells would enable the labelling and manipulation of intracellular antigens, which constitutes a long-thought goal in cell biology and medicine. Here we present a modular strategy to create functional cell-permeable nanobodies capable of targeted labelling and manipulation of intracellular antigens in living cells. The cell-permeable nanobodies are formed by the site-specific attachment of intracellularly stable (or cleavable) cyclic arginine-rich cell-penetrating peptides to camelid-derived single-chain VHH antibody fragments...
August 2017: Nature Chemistry
Kevin Wu, Abigail G Doyle
The field of Ni-catalysed cross-coupling has seen rapid recent growth because of the low cost of Ni, its earth abundance, and its ability to promote unique cross-coupling reactions. Whereas advances in the related field of Pd-catalysed cross-coupling have been driven by ligand design, the development of ligands specifically for Ni has received minimal attention. Here, we disclose a class of phosphines that enable the Ni-catalysed Csp(3) Suzuki coupling of acetals with boronic acids to generate benzylic ethers, a reaction that failed with known ligands for Ni and designer phosphines for Pd...
August 2017: Nature Chemistry
Toru Kondo, Alberta Pinnola, Wei Jia Chen, Luca Dall'Osto, Roberto Bassi, Gabriela S Schlau-Cohen
In oxygenic photosynthesis, light harvesting is regulated to safely dissipate excess energy and prevent the formation of harmful photoproducts. Regulation is known to be necessary for fitness, but the molecular mechanisms are not understood. One challenge has been that ensemble experiments average over active and dissipative behaviours, preventing identification of distinct states. Here, we use single-molecule spectroscopy to uncover the photoprotective states and dynamics of the light-harvesting complex stress-related 1 (LHCSR1) protein, which is responsible for dissipation in green algae and moss...
August 2017: Nature Chemistry
Guoliang Liu, Alex W Robertson, Molly Meng-Jung Li, Winson C H Kuo, Matthew T Darby, Mohamad H Muhieddine, Yung-Chang Lin, Kazu Suenaga, Michail Stamatakis, Jamie H Warner, Shik Chi Edman Tsang
The conversion of oxygen-rich biomass into hydrocarbon fuels requires efficient hydrodeoxygenation catalysts during the upgrading process. However, traditionally prepared CoMoS2 catalysts, although efficient for hydrodesulfurization, are not appropriate due to their poor activity, sulfur loss and rapid deactivation at elevated temperature. Here, we report the synthesis of MoS2 monolayer sheets decorated with isolated Co atoms that bond covalently to sulfur vacancies on the basal planes that, when compared with conventionally prepared samples, exhibit superior activity, selectivity and stability for the hydrodeoxygenation of 4-methylphenol to toluene...
August 2017: Nature Chemistry
Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nakase, Tomoka Takatani-Nakase, Fatemeh Madani, Astrid Gräslund, Shiroh Futaki
One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report an approach to deliver proteins, which include antibodies, into cells by using endosomolytic peptides derived from the cationic and membrane-lytic spider venom peptide M-lycotoxin. The delivery peptides were developed by introducing one or two glutamic acid residues into the hydrophobic face. One peptide with the substitution of leucine by glutamic acid (L17E) was shown to enable a marked cytosolic liberation of antibodies (immunoglobulins G (IgGs)) from endosomes...
August 2017: Nature Chemistry
Chenrui Chen, Junjun Tan, Ming-Chien Hsieh, Ting Pan, Jay T Goodwin, Anil K Mehta, Martha A Grover, David G Lynn
Template-directed polymerization reactions enable the accurate storage and processing of nature's biopolymer information. This mutualistic relationship of nucleic acids and proteins, a network known as life's central dogma, is now marvellously complex, and the progressive steps necessary for creating the initial sequence and chain-length-specific polymer templates are lost to time. Here we design and construct dynamic polymerization networks that exploit metastable prion cross-β phases. Mixed-phase environments have been used for constructing synthetic polymers, but these dynamic phases emerge naturally from the growing peptide oligomers and create environments suitable both to nucleate assembly and select for ordered templates...
August 2017: Nature Chemistry
Hao Sun, Christopher P Kabb, Yuqiong Dai, Megan R Hill, Ion Ghiviriga, Abhijeet P Bapat, Brent S Sumerlin
Macromolecular architecture plays a pivotal role in determining the properties of polymers. When designing polymers for specific applications, it is not only the size of a macromolecule that must be considered, but also its shape. In most cases, the topology of a polymer is a static feature that is inalterable once synthesized. Using reversible-covalent chemistry to prompt the disconnection of chemical bonds and the formation of new linkages in situ, we report polymers that undergo dramatic topological transformations via a process we term macromolecular metamorphosis...
August 2017: Nature Chemistry
Yudong Hao, Martin Kristiansen, Ruojie Sha, Jens J Birktoft, Carina Hernandez, Chengde Mao, Nadrian C Seeman
Structural DNA nanotechnology finds applications in numerous areas, but the construction of objects, 2D and 3D crystalline lattices and devices is prominent among them. Each of these components has been developed individually, and most of them have been combined in pairs. However, to date there are no reports of independent devices contained within 3D crystals. Here we report a three-state 3D device whereby we change the colour of the crystals by diffusing strands that contain dyes in or out of the crystals through the mother-liquor component of the system...
August 2017: Nature Chemistry
Tolulope O Omosun, Ming-Chien Hsieh, W Seth Childers, Dibyendu Das, Anil K Mehta, Neil R Anthony, Ting Pan, Martha A Grover, Keith M Berland, David G Lynn
The protein-only infectious agents known as prions exist within cellular matrices as populations of assembled polypeptide phases ranging from particles to amyloid fibres. These phases appear to undergo Darwinian-like selection and propagation, yet remarkably little is known about their accessible chemical and biological functions. Here we construct simple peptides that assemble into well-defined amyloid phases and define paracrystalline surfaces able to catalyse specific enantioselective chemical reactions...
August 2017: Nature Chemistry
David Lachkar, Natacha Denizot, Guillaume Bernadat, Kadiria Ahamada, Mehdi A Beniddir, Vincent Dumontet, Jean-François Gallard, Régis Guillot, Karine Leblanc, Elvis Otogo N'nang, Victor Turpin, Cyrille Kouklovsky, Erwan Poupon, Laurent Evanno, Guillaume Vincent
Bipleiophylline is a highly complex monoterpene indole alkaloid composed of two pleiocarpamine units anchored on an aromatic spacer platform. The synthesis of bipleiophylline is considered as a mountain to climb by the organic chemistry community. Here, a unified oxidative coupling protocol between indole derivatives and 2,3-dihydroxybenzoic acid, mediated by silver oxide, has been developed to produce the core of bipleiophylline. This method also allows the independent preparation of benzofuro[2,3-b]indolenine and isochromano[3,4-b]indolenine scaffolds, depending only on the nature of the aromatic platform used...
August 2017: Nature Chemistry
Charlotte E Boott, Jessica Gwyther, Robert L Harniman, Dominic W Hayward, Ian Manners
The preparation of well-defined nanoparticles based on soft matter, using solution-processing techniques on a commercially viable scale, is a major challenge of widespread importance. Self-assembly of block copolymers in solvents that selectively solvate one of the segments provides a promising route to core-corona nanoparticles (micelles) with a wide range of potential uses. Nevertheless, significant limitations to this approach also exist. For example, the solution processing of block copolymers generally follows a separate synthesis step and is normally performed at high dilution...
August 2017: Nature Chemistry
Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T Hong, Yueh-Lin Lee, Livia Giordano, Kelsey A Stoerzinger, Marc T M Koper, Yang Shao-Horn
This corrects the article DOI: 10.1038/nchem.2695.
July 25, 2017: Nature Chemistry
Bruce C Gibb
No abstract text is available yet for this article.
July 25, 2017: Nature Chemistry
Macarena Sánchez-Navarro, Meritxell Teixidó, Ernest Giralt
No abstract text is available yet for this article.
July 25, 2017: Nature Chemistry
Emad F Aziz, M Hannelore Rittmann-Frank, Kathrin M Lange, Sébastien Bonhommeau, Majed Chergui
This corrects the article DOI: 10.1038/nchem.807.
July 25, 2017: Nature Chemistry
Peter J Walla
No abstract text is available yet for this article.
July 25, 2017: Nature Chemistry
Adrian Dingle
No abstract text is available yet for this article.
July 25, 2017: Nature Chemistry
(no author information available yet)
This corrects the article DOI: 10.1038/nchem.2787.
July 25, 2017: Nature Chemistry
Anders Nilsson
This corrects the article DOI: 10.1038/nchem.768.
July 25, 2017: Nature Chemistry
Diego B Diaz, Andrei K Yudin
Boron-containing molecules have been extensively used for the purposes of chemical sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it can coordinate to heteroatoms such as oxygen and nitrogen. This reversible covalent mode of interaction has led to the use of boron as bait for nucleophilic residues in disease-associated proteins, culminating in the approval of new therapeutics that work by covalent mechanisms. Our analysis of a wide range of covalent inhibitors with electrophilic groups suggests that boron is a unique electrophile in its chameleonic ability to engage protein targets...
July 25, 2017: Nature Chemistry
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