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Cancer Cytopathology

Hila Benjamin, Temima Schnitzer-Perlman, Alexander Shtabsky, Christopher J VandenBussche, Syed Z Ali, Zdenek Kolar, Fabio Pagni, Dganit Bar, Eti Meiri
BACKGROUND: The majority of thyroid nodules are diagnosed using fine-needle aspiration (FNA) biopsies. The authors recently described the clinical validation of a molecular microRNA-based assay, RosettaGX Reveal, which can diagnose thyroid nodules as benign or suspicious using a single stained FNA smear. This paper describes the analytical validation of the assay. METHODS: More than 800 FNA slides were tested, including slides stained with Romanowsky-type and Papanicolaou stains...
October 2016: Cancer Cytopathology
Andrew H Fischer, Lloyd M Hutchinson
No abstract text is available yet for this article.
September 6, 2016: Cancer Cytopathology
Rosemary H Tambouret
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
Zubair W Baloch, Raja R Seethala, William C Faquin, Mauro G Papotti, Fulvio Basolo, Guido Fadda, Gregory W Randolph, Steven P Hodak, Yuri E Nikiforov, Susan J Mandel
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
Kyuichi Kadota, Yumi Miyai, Naomi Katsuki, Yoshio Kushida, Toru Matsunaga, Masaya Okuda, Hiroyasu Yokomise, Nobuhiro Kanaji, Shuji Bandoh, Reiji Haba
BACKGROUND: In patients with resected non-small cell lung cancer (NSCLC), the prognostic value of nuclear grade has been demonstrated. However, among patients with advanced, unresectable NSCLC, the prognostic usefulness of cytological nuclear grade to the authors' knowledge remains unknown. In the current study, the authors used transbronchial cytology to investigate whether nuclear morphometry correlated with clinical outcomes in patients with advanced NSCLC. METHODS: The authors reviewed patients with advanced, unresectable NSCLC who were diagnosed on transbronchial cytology and were treated at the study institution from 2007 through 2015 (97 patients)...
September 2016: Cancer Cytopathology
Hoa V Pham, Liron Pantanowitz, Yang Liu
BACKGROUND: A definitive diagnosis of urothelial carcinoma in urine cytology is often challenging and subjective. Many urine cytology samples receive an indeterminate diagnosis. Ancillary techniques such as fluorescence in situ hybridization (FISH) have been used to improve the diagnostic sensitivity, but FISH is not approved as a routine screening test, and the complex fluorescent staining protocol also limits its widespread clinical use. Quantitative phase imaging (QPI) is an emerging technology allowing accurate measurements of the single-cell dry mass...
September 2016: Cancer Cytopathology
Mingjuan L Zhang, Alan X Guo, Christopher J VandenBussche
BACKGROUND: The Paris System for Reporting Urinary Cytology (TPS) has defined nuclear-to-cytoplasmic (N:C) ratio cutoff values for several of its risk-stratified diagnostic categories. However, because pathologists are not trained to recognize strict N:C ratio cutoff values, a previously designed survey was used to determine whether pathologists could accurately identify N:C ratios according to TPS standards. METHODS: Participants were instructed to estimate the N:C ratio of ideal (line drawing) and real (cell photograph) images presented via an online survey...
September 2016: Cancer Cytopathology
Eric J Yang, Jason L Hornick, Xiaohua Qian
BACKGROUND: Soft tissue perineurioma (STP) is a benign peripheral nerve sheath tumor demonstrating uniform perineurial cell differentiation. To the authors' knowledge, the cytomorphologic features of STP remain incompletely characterized, and the distinction between STP and its benign (intramuscular/cellular myxoma) and malignant (low-grade fibromyxoid sarcoma [LGFMS]) mimics is challenging. METHODS: Fine-needle aspiration (FNA)/core needle biopsies of 25 low-grade myxoid spindle cell neoplasm cases including STP (5 cases), intramuscular/cellular myxoma (16 cases), and LGFMS (4 cases) were reviewed retrospectively for cytomorphologic and immunophenotypic comparison...
September 2016: Cancer Cytopathology
Giuseppe Mancuso, Enrica Bovio, Ottavio Rena, Eltjona Rrapaj, Francesca Mercalli, Claudia Veggiani, Alessia Paganotti, Silvano Andorno, Renzo Boldorini
BACKGROUND: Small cell lung cancer (SCLC) is a highly aggressive neoplasm that accounts for approximately 10% to 15% of lung cancers. In most cases, the diagnosis relies on cytology and needs to be confirmed by immunohistochemistry. Although several genetic and molecular abnormalities have been recorded, molecular markers able to predict the prognosis are still lacking. MicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing...
September 2016: Cancer Cytopathology
Francisco Beca, Fernando Schmitt
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
Rachel L Geller, Kim Hookim, Harold C Sullivan, Lauren N Stuart, Mark A Edgar, Michelle D Reid
BACKGROUND: This study describes the cytologic features of 26 angiosarcomas diagnosed on fine-needle aspiration. METHODS: Twenty-six angiosarcomas from 20 patients were confirmed by cytomorphology and immunocytochemical (immunohistochemistry) positivity for at least 2 of 3 vascular markers. Specimens were examined for spindled/epithelioid/plasmacytoid single cells, 3-dimensional clusters, multiple prominent/bar-shaped nucleoli (5 times longer than their width), chromatin strands, abnormal mitoses, necrosis, and vasoformative features...
September 2016: Cancer Cytopathology
Derek B Allison, Paul E Wakely, Momin T Siddiqui, Syed Z Ali
BACKGROUND: Nodular fasciitis (NF) is a benign, self-limited, fibroblastic/myofibroblastic proliferation that is diagnostically challenging, often mimicking a malignant process due to its rapid growth clinically and its high cellularity, mitotic activity, and variable/nonspecific cytomorphologic findings. Herein, the authors report what to their knowledge is the largest and first multi-institutional study of the cytomorphologic characteristics of NF by fine-needle aspiration (FNA). METHODS: The pathology archives at The Johns Hopkins Hospital, The Ohio State University Wexner Medical Center, and Emory University Hospital were searched for soft tissue FNA cytology specimens of masses confirmed to be NF...
August 15, 2016: Cancer Cytopathology
Terence J Colgan
No abstract text is available yet for this article.
August 2016: Cancer Cytopathology
Garth W Garrison
No abstract text is available yet for this article.
August 2016: Cancer Cytopathology
Jennifer M Roberts, Fengyi Jin, Julia K Thurloe, Deborah Ekman, Marjorie K Adams, Ross L McDonald, Clare Biro, I Mary Poynten, Andrew E Grulich, Annabelle Farnsworth
BACKGROUND: In a cytology-based screening program intended to prevent anal cancer, the anal transformation zone (TZ) should be adequately sampled because it is the site most susceptible to the development of the cancer precursor, high-grade squamous intraepithelial lesion (HSIL). An adequate TZ component is defined as comprising at least 10 rectal columnar or squamous metaplastic cells. In the current study, the authors examined whether the presence of a TZ component in anal cytology correlated with the detection of histological HSIL...
August 2016: Cancer Cytopathology
Nazim Benzerdjeb, Christian Garbar, Philippe Camparo, Henri Sevestre
BACKGROUND: The liquid-based cytology Papanicolaou (Pap) test has gradually replaced the conventional Pap test, as it seems to be more efficient, in part because it uses computer assistance. However, Pap test diagnoses are still subjective and are cost-consuming or time-consuming. The authors describe a new digital holographic microscopy instrument and accompanying software. This technology provides an instantaneous, 3-dimensional image reconstruction of cells directly from the uterine cervical sample vial...
August 2016: Cancer Cytopathology
Dinesh Pradhan, Zaibo Li, Rebecca Ocque, Stell Patadji, Chengquan Zhao
BACKGROUND: The interpretation of atypical glandular cells (AGC) in Papanicolaou (Pap) tests and screening for glandular neoplasia remain challenging. METHODS: Pap tests with an AGC interpretation from January 2008 to December 2013 were retrieved from a pathology database, and cases with histologic follow-up within 1 year were included in the study. RESULTS: There were 589,830 Pap tests during the study period, and 3709 cases (0.6%) were reported as AGC, which included the following: AGC, not otherwise specified (52...
August 2016: Cancer Cytopathology
Dorothy L Rosenthal
No abstract text is available yet for this article.
August 2016: Cancer Cytopathology
Chi-Shun Yang, Shaoxiong Chen, Harvey M Cramer, Howard H Wu
BACKGROUND: The significance of apoptosis and its association with high-grade urothelial carcinoma (HGUC) in urine cytology has yet to be determined. METHODS: A computerized search of the study laboratory information system was performed over a 3-year period for all urine cytology specimens processed using the SurePath liquid-based preparation technique. Only those cases with correlating surgical pathology obtained within 6 months after the urine cytologic samples were included in the current study...
August 2016: Cancer Cytopathology
Adriana T Lorenzi, José Humberto T Fregnani, Júlio César Possati-Resende, Márcio Antoniazzi, Cristovam Scapulatempo-Neto, Stina Syrjänen, Luisa L Villa, Adhemar Longatto-Filho
BACKGROUND: Human papillomavirus (HPV) DNA testing can be crucial for women who have limited access to traditional screening. The current study compared the results obtained through HPV DNA testing with those obtained through cytology-based screening. METHODS: A total of 3068 women aged 18 to 85 years were enrolled in an opportunistic cervical cancer screening program developed by the Barretos Cancer Hospital and performed by a team of health professionals working within a mobile unit from March to December 2012, followed by statistical analyses...
August 2016: Cancer Cytopathology
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