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Cancer Cytopathology

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https://www.readbyqxmd.com/read/27647802/next-generation-sequencing-adds-value-to-the-preoperative-diagnosis-of-pancreatic-cysts
#1
Matthew W Rosenbaum, Martin Jones, Jonathan C Dudley, Long P Le, A John Iafrate, Martha B Pitman
BACKGROUND: The diagnosis of a pancreatic cyst as mucinous or high-risk dictates the need for follow-up or surgery. Molecular analysis of aspirated pancreatic cyst fluid (PCF) can provide valuable information not obtained by carcinoembryonic antigen (CEA) analysis or cytology. METHODS: All patients who underwent molecular analysis of PCF between March 2013 and June 2015 were reviewed, including pathology, imaging, and follow-up. Molecular testing was performed using a patented, anchored multiplex polymerase chain reaction next-generation sequencing (NGS) platform, which sequenced numerous hotspots in 39 genes linked with malignancy...
September 20, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27636377/cytomorphology-of-clear-cell-papillary-renal-cell-carcinoma
#2
Xiaoqi Lin
BACKGROUND: Clear cell papillary renal cell carcinoma (CCPRCC) shares some morphologic and immunohistochemical markers with clear cell RCC and papillary RCC. To the author's knowledge, its cytomorphology on fine-needle aspiration (FNA) or touch preparations (TPs) of core needle biopsy specimens has not been well delineated in the English language literature. METHODS: The FNA/TP cytomorphology of 7 retrieved cases was studied. RESULTS: The tumor cells were arranged in small nests (100%), 3-dimensional clusters (71%), papillary/tubular/acinar arrays (43%), and as single cells (57%)...
September 16, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27636204/diagnosis-of-trichomoniasis-in-men-by-urine-cytology
#3
Erika E Doxtader, Tarik M Elsheikh
BACKGROUND: Trichomonas vaginalis is a rare finding in urine cytology specimens, especially those from men; only 2 case reports have been described in the literature. The authors of the current report sought to determine the incidence and clinical significance of this finding in urine cytology in males. METHODS: The authors' cytopathology archives were queried for urine cytology specimens that contained Trichomonas over a 30-year period. Clinical information from men with Trichomonas-positive urines was reviewed retrospectively...
September 16, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27636102/cytology-smears-as-excellent-starting-material-for-next-generation-sequencing-based-molecular-testing-of-patients-with-adenocarcinoma-of-the-lung
#4
Nadezda P Velizheva, Markus P Rechsteiner, Christine E Wong, Qing Zhong, Matthias Rössle, Beata Bode, Holger Moch, Alex Soltermann, Peter J Wild, Verena Tischler
BACKGROUND: Molecular testing of lung adenocarcinomas (ADCs) is crucial for therapy stratification of patients. Because of the often limited diagnostic material, the authors aimed to explore the suitability of cytology smears for next-generation sequencing (NGS) and compared the results with concurrent histological specimens or cell blocks. METHODS: A total of 16 formalin-fixed paraffin-embedded (FFPE) ADCs with known genetic alterations were used as the first cohort for targeted DNA and RNA sequencing...
September 16, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27223344/analytical-validity-of-a-microrna-based-assay-for-diagnosing-indeterminate-thyroid-fna-smears-from-routinely-prepared-cytology-slides
#5
Hila Benjamin, Temima Schnitzer-Perlman, Alexander Shtabsky, Christopher J VandenBussche, Syed Z Ali, Zdenek Kolar, Fabio Pagni, Dganit Bar, Eti Meiri
BACKGROUND: The majority of thyroid nodules are diagnosed using fine-needle aspiration (FNA) biopsies. The authors recently described the clinical validation of a molecular microRNA-based assay, RosettaGX Reveal, which can diagnose thyroid nodules as benign or suspicious using a single stained FNA smear. This paper describes the analytical validation of the assay. METHODS: More than 800 FNA slides were tested, including slides stained with Romanowsky-type and Papanicolaou stains...
October 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27598019/technical-and-us-regulatory-issues-in-triaging-material-for-the-molecular-laboratory
#6
Andrew H Fischer, Lloyd M Hutchinson
No abstract text is available yet for this article.
September 6, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27479463/use-of-immunohistochemical-staining-for-p16-in-gynecological-cytology
#7
Rosemary H Tambouret
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27203786/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-a-changing-paradigm-in-thyroid-surgical-pathology-and-implications-for-thyroid-cytopathology
#8
Zubair W Baloch, Raja R Seethala, William C Faquin, Mauro G Papotti, Fulvio Basolo, Guido Fadda, Gregory W Randolph, Steven P Hodak, Yuri E Nikiforov, Susan J Mandel
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27177186/nuclear-grade-based-on-transbronchial-cytology-is-an-independent-prognostic-factor-in-patients-with-advanced-unresectable-non-small-cell-lung-cancer
#9
Kyuichi Kadota, Yumi Miyai, Naomi Katsuki, Yoshio Kushida, Toru Matsunaga, Masaya Okuda, Hiroyasu Yokomise, Nobuhiro Kanaji, Shuji Bandoh, Reiji Haba
BACKGROUND: In patients with resected non-small cell lung cancer (NSCLC), the prognostic value of nuclear grade has been demonstrated. However, among patients with advanced, unresectable NSCLC, the prognostic usefulness of cytological nuclear grade to the authors' knowledge remains unknown. In the current study, the authors used transbronchial cytology to investigate whether nuclear morphometry correlated with clinical outcomes in patients with advanced NSCLC. METHODS: The authors reviewed patients with advanced, unresectable NSCLC who were diagnosed on transbronchial cytology and were treated at the study institution from 2007 through 2015 (97 patients)...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27177072/quantitative-phase-imaging-to-improve-the-diagnostic-accuracy-of-urine-cytology
#10
Hoa V Pham, Liron Pantanowitz, Yang Liu
BACKGROUND: A definitive diagnosis of urothelial carcinoma in urine cytology is often challenging and subjective. Many urine cytology samples receive an indeterminate diagnosis. Ancillary techniques such as fluorescence in situ hybridization (FISH) have been used to improve the diagnostic sensitivity, but FISH is not approved as a routine screening test, and the complex fluorescent staining protocol also limits its widespread clinical use. Quantitative phase imaging (QPI) is an emerging technology allowing accurate measurements of the single-cell dry mass...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27159533/morphologists-overestimate-the-nuclear-to-cytoplasmic-ratio
#11
Mingjuan L Zhang, Alan X Guo, Christopher J VandenBussche
BACKGROUND: The Paris System for Reporting Urinary Cytology (TPS) has defined nuclear-to-cytoplasmic (N:C) ratio cutoff values for several of its risk-stratified diagnostic categories. However, because pathologists are not trained to recognize strict N:C ratio cutoff values, a previously designed survey was used to determine whether pathologists could accurately identify N:C ratios according to TPS standards. METHODS: Participants were instructed to estimate the N:C ratio of ideal (line drawing) and real (cell photograph) images presented via an online survey...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27159449/fine-needle-aspiration-of-soft-tissue-perineurioma-a-comparative-analysis-of-cytomorphology-and-immunohistochemistry-with-benign-and-malignant-mimics
#12
Eric J Yang, Jason L Hornick, Xiaohua Qian
BACKGROUND: Soft tissue perineurioma (STP) is a benign peripheral nerve sheath tumor demonstrating uniform perineurial cell differentiation. To the authors' knowledge, the cytomorphologic features of STP remain incompletely characterized, and the distinction between STP and its benign (intramuscular/cellular myxoma) and malignant (low-grade fibromyxoid sarcoma [LGFMS]) mimics is challenging. METHODS: Fine-needle aspiration (FNA)/core needle biopsies of 25 low-grade myxoid spindle cell neoplasm cases including STP (5 cases), intramuscular/cellular myxoma (16 cases), and LGFMS (4 cases) were reviewed retrospectively for cytomorphologic and immunophenotypic comparison...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27153322/prognostic-impact-of-a-3-microrna-signature-in-cytological-samples-of-small-cell-lung-cancer
#13
Giuseppe Mancuso, Enrica Bovio, Ottavio Rena, Eltjona Rrapaj, Francesca Mercalli, Claudia Veggiani, Alessia Paganotti, Silvano Andorno, Renzo Boldorini
BACKGROUND: Small cell lung cancer (SCLC) is a highly aggressive neoplasm that accounts for approximately 10% to 15% of lung cancers. In most cases, the diagnosis relies on cytology and needs to be confirmed by immunohistochemistry. Although several genetic and molecular abnormalities have been recorded, molecular markers able to predict the prognosis are still lacking. MicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27153190/microrna-signatures-in-cytopathology-are-they-ready-for-prime-time
#14
EDITORIAL
Francisco Beca, Fernando Schmitt
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27088896/cytologic-features-of-angiosarcoma-a-review-of-26-cases-diagnosed-on-fna
#15
Rachel L Geller, Kim Hookim, Harold C Sullivan, Lauren N Stuart, Mark A Edgar, Michelle D Reid
BACKGROUND: This study describes the cytologic features of 26 angiosarcomas diagnosed on fine-needle aspiration. METHODS: Twenty-six angiosarcomas from 20 patients were confirmed by cytomorphology and immunocytochemical (immunohistochemistry) positivity for at least 2 of 3 vascular markers. Specimens were examined for spindled/epithelioid/plasmacytoid single cells, 3-dimensional clusters, multiple prominent/bar-shaped nucleoli (5 times longer than their width), chromatin strands, abnormal mitoses, necrosis, and vasoformative features...
September 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27529763/algorithmic-approach-to-neuroendocrine-tumors-in-targeted-biopsies-practical-applications-of-immunohistochemical-markers
#16
Kai Duan, Ozgur Mete
Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms with distinct biological behaviors, depending on the site of origin and the degree of tumor proliferation. Although advances in biochemical and radiological modalities have enhanced the ability to detect NETs, tissue diagnosis remains the gold standard to assess tumor characteristics for treatment decision making. In an era with growing demands for precision diagnostics based on smaller tissue samples, immunohistochemistry has become an indispensable tool in the pathologist's repertoire...
August 16, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27525591/nodular-fasciitis-a-frequent-diagnostic-pitfall-on-fine-needle-aspiration
#17
Derek B Allison, Paul E Wakely, Momin T Siddiqui, Syed Z Ali
BACKGROUND: Nodular fasciitis (NF) is a benign, self-limited, fibroblastic/myofibroblastic proliferation that is diagnostically challenging, often mimicking a malignant process due to its rapid growth clinically and its high cellularity, mitotic activity, and variable/nonspecific cytomorphologic findings. Herein, the authors report what to their knowledge is the largest and first multi-institutional study of the cytomorphologic characteristics of NF by fine-needle aspiration (FNA). METHODS: The pathology archives at The Johns Hopkins Hospital, The Ohio State University Wexner Medical Center, and Emory University Hospital were searched for soft tissue FNA cytology specimens of masses confirmed to be NF...
August 15, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27525382/interobserver-agreement-in-the-cytologic-grading-of-atypia-in-neoplastic-pancreatic-mucinous-cysts-with-the-2-tiered-approach
#18
Abha Goyal, Fadi W Abdul-Karim, Bin Yang, Jinesh B Patel, Jennifer A Brainard
BACKGROUND: The accurate cytologic grading of epithelial atypia in fine-needle aspirates of pancreatic mucinous cysts has important implications for clinical management. The Papanicolaou Society of Cytopathology has recommended a 2-tiered system of low-grade (LG) and high-grade (HG) for grading this atypia. Using this approach, this study examined the interobserver agreement within a group of cytopathologists at the Cleveland Clinic. METHODS: Twenty cases of fine-needle aspiration of pancreatic neoplastic mucinous cysts with documented histologic follow-up and representative lesional cells were selected...
August 15, 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27517169/gynecologic-cytology-in-cancer-cytopathology-20-years-of-massive-change
#19
EDITORIAL
Terence J Colgan
No abstract text is available yet for this article.
August 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27412637/lung-cancer-screening
#20
Garth W Garrison
No abstract text is available yet for this article.
August 2016: Cancer Cytopathology
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