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Cancer Cytopathology

Patrick J McIntire, Justin T Snow, Sarah S Elsoukkary, Lauren Soong, Jacob Sweeney, Brian D Robinson, Momin T Siddiqui
BACKGROUND: Urinary cytology is sensitive and specific for diagnosing and screening high-grade urothelial carcinomas (HGUC). The Paris System (TPS) for urinary cytology was introduced in 2016 to standardize reporting. According to TPS diagnostic categories of HGUC and suspicious for HGUC (SHGUC), the average nuclear-to-cytoplasm (N:C) ratio of atypical cells should be ≥0.7. The objective of the current study was to measure the N:C ratio of urine cytology specimens with HGUC and SHGUC diagnoses and biopsy-proven HGUC follow-up...
November 5, 2018: Cancer Cytopathology
Yigu Chen, Paul A VanderLaan, Yael K Heher
Cases in Quality & Safety is a new feature focused on the applications of quality and patient safety tools to cytopathology-related patient safety events. The goal is to illustrate the practical use of various patient safety and quality improvement tools for incident investigation and error prevention. These tools will be linked with another feature, QA Q&A. We are seeking cytopathology-related quality and patient safety case submissions, and will provide assistance in analyzing local events for publication under Cases in Quality & Safety...
November 5, 2018: Cancer Cytopathology
Yukiko Matsuo, Tsutomu Yoshida, Kazuya Yamashita, Yukitoshi Satoh
BACKGROUND: Liquid-based cytology (LBC) is a useful cytopathological method, and LBC lung adenocarcinoma specimens may be used for genetic analysis in the near future. In the current study, the authors determined whether LBC specimens can be used for epidermal growth factor receptor (EGFR) mutation analysis in human lung adenocarcinoma cell lines. METHODS: Genomic DNA was extracted from 3 lung adenocarcinoma cell lines that were fixed in LBC preservation solution using 2 protocols (one for cultured cells and one for tissues) of a DNA extraction kit...
October 21, 2018: Cancer Cytopathology
Irene Shyu, Leili Mirsadraei, Xiaoyan Wang, Valentina Robila, Rohit Mehra, Jonathan B McHugh, Ying-Bei Chen, Aaron M Udager, Anthony J Gill, Liang Cheng, Mahul B Amin, Oscar Lin, Steven Christopher Smith
BACKGROUND: Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is rare and highly aggressive and is believed to arise mostly in the setting of hereditary leiomyomatosis-RCC syndrome with a germline mutation of FH. Because of the aggressiveness of these tumors and a frequent lack of ascertainable family history, these tumors may first present as metastases and be sampled by cytology. The cytologic findings of FH-deficient RCC have not previously been reported. METHODS: Cytologic and limited biopsy samples from patients with FH-deficient RCC were reviewed retrospectively...
October 19, 2018: Cancer Cytopathology
Alfred H Böcking, David Friedrich, Dietrich Meyer-Ebrecht, Chenyan Zhu, Anna Feider, Stefan Biesterfeld
BACKGROUND: The average sensitivity of conventional cytology for the identification of cancer cells in effusion specimens is only approximately 58%. DNA image cytometry (DNA-ICM), which exploits the DNA content of morphologically suspicious nuclei measured on digital images, has a sensitivity of up to 91% for the detection of cancer cells. However, when performed manually, to our knowledge to date, an expert needs approximately 60 minutes for the analysis of a single slide. METHODS: In the current study, the authors present a novel method of supervised machine learning for the automated identification of morphologically suspicious mesothelial and epithelial nuclei in Feulgen-stained effusion specimens...
October 19, 2018: Cancer Cytopathology
Liron Pantanowitz
No abstract text is available yet for this article.
October 14, 2018: Cancer Cytopathology
Sinchita Roy-Chowdhuri
No abstract text is available yet for this article.
October 14, 2018: Cancer Cytopathology
Jack Yang, Alexis Elliott, Anne L Hoffa, Nicole Herring, Patricia M Houser
BACKGROUND: The p16 immunohistochemical (IHC) marker has been used increasingly as an adjunct to morphologic assessment of cervical biopsies in which the differential diagnoses include high-grade squamous intraepithelial lesion (HSIL) and its mimics. The objective of this study was to assess the potential influence of p16 IHC staining on the evaluation of cervical biopsy as observed through cytologic-histologic correlation (CHC). METHODS: Cervical biopsy samples that had cytologic diagnoses of either low-grade squamous intraepithelial lesion (LSIL) or HSIL and also had histologic follow-up were retrieved from the department database...
October 11, 2018: Cancer Cytopathology
Anthony D Cretara, Christopher N Otis
In previous editorials, Chapman and Otis in 2011 and Layfield in 2014 have summarized much of the work responsible for establishing the concept of critical diagnoses in surgical pathology and cytopathology. Both editorials end with a list of 8 key policy points needed for an effective strategy of handling and communicating critical diagnoses. We have developed and distributed a Web-based survey to elicit clinicians' attitudes regarding many of those key policy points, such as how, when, and to whom critical diagnoses should be reported; we have allowed some level of collaboration with the clinical staff when developing our communication policies as the Association of Directors of Anatomic and Surgical Pathology (ADASP) consensus statement recommends...
October 6, 2018: Cancer Cytopathology
Bryn Nelson
No abstract text is available yet for this article.
November 2018: Cancer Cytopathology
Eleanor Russell-Goldman, Jason L Hornick, Xiaohua Qian, Vickie Y Jo
BACKGROUND: Ewing sarcoma (ES) is a round cell sarcoma that can be challenging to diagnose on cytologic material given its significant overlap with numerous mesenchymal, epithelial, and lymphoid cytomorphologic mimics. The objective of this study was to assess the utility of a novel marker, NKX2.2, in the diagnosis of ES in cytologic material and its ability to distinguish ES from its mimics. METHODS: NKX2.2 immunohistochemistry was performed on cell blocks from 107 fine-needle aspirations, and nuclear expression was scored semiquantitatively for extent and intensity...
November 2018: Cancer Cytopathology
Rachel D Conrad, Angela H Liu, Nicolas Wentzensen, Roy R Zhang, S Terence Dunn, Sophia S Wang, Mark Schiffman, Michael A Gold, Joan L Walker, Rosemary E Zuna
BACKGROUND: New cervical cancers continue to be diagnosed despite the success of Papanicolaou (Pap) tests. In an effort to identify pitfalls that limit the diagnosis of adenocarcinoma, the authors reviewed the cytologic characteristics of endocervical adenocarcinomas in their patient population. METHODS: Liquid-based cytology slides from 45 women who had concurrent, histologically confirmed cervical adenocarcinomas were reviewed retrospectively and semiquantitatively for 25 key cytologic traits...
November 2018: Cancer Cytopathology
Esther Diana Rossi, William C Faquin
No abstract text is available yet for this article.
November 2018: Cancer Cytopathology
Jen-Fan Hang, Fatimah Alruwaii, Bao-Rung Zeng, Chiung-Ru Lai, Howard H Wu
BACKGROUND: The newly unveiled Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has proposed salivary gland neoplasm of uncertain malignant potential (SUMP) as an indeterminate category. The category is reserved for fine-needle aspiration (FNA) cases that are diagnostic of a salivary gland neoplasm but cannot be further designated as a specific tumor type. The objective of the current study was to evaluate the clinical utility of subtyping SUMP cases based on different cell types...
November 2018: Cancer Cytopathology
Carrie Lubitz
No abstract text is available yet for this article.
November 2018: Cancer Cytopathology
John S Abele
This review updates a 2008 report on the establishment of a pathologist-directed ultrasound-guided fine needle aspiration (USGFNA) biopsy clinic in a private practice setting. During this time, ultrasound evaluation of the thyroid has evolved from simply sampling a nodule to a reliable cancer risk assessment (CRA). Because of perceived poor reliability in many local radiology thyroid ultrasound reports, first endocrinologists and then pathologists began performing their own ultrasound evaluations, cancer risk assessments, and USGFNAs...
November 2018: Cancer Cytopathology
Paweł Gajdzis, Marick Laé, Jerzy Klijanienko
BACKGROUND: Epithelioid sarcoma (ES) is a rare mesenchymal tumor that is divided into 2 types: classic and proximal. To the authors' knowledge, ES has been poorly studied in cytology, with fewer than 50 cases reported to date. The objective of the current study was to analyze the cytological and immunohistochemical information regarding 5 cases of ES. METHODS: Five cases of ES were analyzed: 4 of proximal type and 1 of classic type. The cases were taken from 4 female patients and 1 male patient...
November 2018: Cancer Cytopathology
Bryn Nelson
No abstract text is available yet for this article.
October 2018: Cancer Cytopathology
Maighan A Seagrove-Guffey, Haris Hatic, Haoran Peng, Kimberly C Bates, A Ola Odugbesan
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was created to establish a standard terminology regarding thyroid nodules that can be shared between endocrinologists, pathologists, radiologists, and surgeons. Since its inception and use in 2009, multiple large hospitals and academic institutions have performed retrospective studies to compare their classification rates, specifically those of atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), with the recommended rates created by the National Cancer Institute...
October 2018: Cancer Cytopathology
Ricardo G Pastorello, Camila Destefani, Pedro H Pinto, Caroline H Credidio, Rafael X Reis, Thiago de A Rodrigues, Maryane C de Toledo, Louise De Brot, Felipe de A Costa, Antonio G do Nascimento, Clóvis A L Pinto, Mauro A Saieg
BACKGROUND: The impact of rapid on-site evaluation (ROSE) on thyroid aspirates has been a matter of extensive debate. In the current study, the authors reviewed all thyroid fine-needle aspiration biopsies (FNABs) performed in their service in recent years to evaluate the impact of ROSE on final adequacy and diagnostic rates. METHODS: All ultrasound-guided FNABs of the thyroid performed between July 2015 and July 2017 were included retrospectively. ROSE was performed by experienced cytopathologists, with production of Romanowsky-stained slides for immediate evaluation...
October 2018: Cancer Cytopathology
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