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Cancer Cytopathology

Sylvan C Baca, Kristine S Wong, Kyle C Strickland, Howard T Heller, Matthew I Kim, Justine A Barletta, Edmund S Cibas, Jeffrey F Krane, Ellen Marqusee, Trevor E Angell
BACKGROUND: Thyroid nodules with atypia of undetermined significance (AUS) on fine-needle aspiration (FNA) have a low risk of malignancy that appears to vary based on specific features described in the AUS diagnosis. The Afirma gene expression classifier (GEC) is a molecular test designed to improve preoperative risk stratification of thyroid nodules, but its performance for different patterns of AUS has not been defined. The objective of this study was to assess GEC results and clinical outcomes in AUS nodules with architectural atypia (AUS-A), cytologic atypia (AUS-C) or both (AUS-C/A)...
May 2017: Cancer Cytopathology
Anthony E Samir
No abstract text is available yet for this article.
November 2016: Cancer Cytopathology
Claudio Bellevicine, Roberta Sgariglia, Umberto Malapelle, Elena Vigliar, Mariantonia Nacchio, Giuseppe Ciancia, Markus Eszlinger, Ralf Paschke, Giancarlo Troncone
BACKGROUND: Fine-needle aspiration (FNA) cytology is accurate and cost-effective in the evaluation of thyroid nodules. Molecular techniques may contribute to risk stratification in indeterminate cases. Although next-generation sequencing (NGS) is a promising technique for the molecular testing of thyroid FNA specimens, thyroid-specific cancer gene panels are not commercially available. Conversely, the Ion AmpliSeq Cancer Hotspot Panel v2 (CHPv2), which includes the genes most frequently mutated in thyroid neoplasms, is commercially available and may represent an alternative to thyroid-specific panels...
November 2016: Cancer Cytopathology
Jeffrey F Krane, Erik K Alexander, Edmund S Cibas, Justine A Barletta
No abstract text is available yet for this article.
November 2016: Cancer Cytopathology
Anthony M Joudi, Stefan E Pambuccian, Eva M Wojcik, Güliz A Barkan
BACKGROUND: "The Paris System" proposes a 7-tier classification system for urine cytology. Establishing the risk of malignancy (ROM) associated with these diagnostic categories is essential to determine the appropriate management of patients. The objective of this study was to determine the ROM associated with the "positive" and "suspicious" categories. METHODS: The authors searched their electronic records for urine cytology specimens that had been diagnosed as "positive" or "suspicious" for high-grade urothelial carcinoma within an 11-year time frame...
November 2016: Cancer Cytopathology
Galab M Hassan, Sarto C Paquin, Roula Albadine, Gilles Gariépy, Geneviève Soucy, Bich N Nguyen, Anand V Sahai
BACKGROUND: Pelvic endoscopic ultrasound-guided fine-needle aspiration (PEUS-FNA) of rectal or perirectal lesions is safe, minimally invasive, and well tolerated. It provides valuable information, which can greatly influence patient management. Herein, the authors present what to their knowledge is the largest series to date of PEUS-FNA. METHODS: PEUS-FNA specimens were retrieved from the archives of the study institution from January 2001 to March 2015. Only patients with solid pelvic lesions were examined...
November 2016: Cancer Cytopathology
Elmira Amirazodi, Evan J Propst, Catherine T Chung, Dimitri A Parra, Jonathan D Wasserman
BACKGROUND: Thyroid malignancy is rare in young children, although the incidence increases sharply during adolescence. Nodular thyroid disease and thyroid cancer in children differ substantially from those in adults, because the rates of malignancy among children are roughly 5-fold higher, and local and distant metastases as well as recurrences are more common. Even with the recent introduction of pediatric guidelines, there remains a paucity of pediatric data on which to base clinical decision making...
November 2016: Cancer Cytopathology
Hani Ibrahim Channir, Christian Grønhøj Larsen, Lise Barlebo Ahlborn, Thomas van Overeem Hansen, Thomas Alexander Gerds, Birgitte Wittenborg Charabi, Ben Vainer, Christian von Buchwald, Christel Braemer Lajer, Katalin Kiss
BACKGROUND: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) often presents with cystic cervical metastasis and a small primary tumor localized in the palatine tonsils or base of the tongue, which is diagnostically challenging. Testing for HPV DNA in fine-needle aspiration (FNA) smears from metastases may facilitate a targeted diagnostic workup for identifying the primary tumor. This study was designed to assess the ability to detect HPV DNA in FNA smears with polymerase chain reaction (PCR)...
November 2016: Cancer Cytopathology
Ted Gansler, Stacey A Fedewa, Chun Chieh Lin, Ahmedin Jemal, Elizabeth M Ward
BACKGROUND: Cytology is an accurate, safe, cost-effective, and guideline-recommended method for pancreatic cancer diagnosis, particularly for unresectable disease. However, to the authors' knowledge, the frequency and determinants of its use have not been described to date. The current study examined patterns of cytological diagnosis among patients with unresectable pancreatic cancer by treatment facility type and by patient characteristics. METHODS: The prevalence of definitive cytological diagnosis (cytology only, without confirmatory histology) versus histological diagnosis (with or without accompanying cytology) was examined in National Cancer Data Base records of 13,657 patients diagnosed with unresectable (American Joint Committee on Cancer stages III and IV) pancreatic cancer in 2011 and 2012 who did not undergo surgical treatment (mode of diagnosis could not be ascertained for surgical patients)...
November 2016: Cancer Cytopathology
Vicki J Schnadig
No abstract text is available yet for this article.
November 2016: Cancer Cytopathology
Luana Andrade, Vitória Lana Massarente, Stéphanie Corradini Tormin, Karina Braga Ribeiro, Geanete Pozzan, Mauro Ajaj Saieg
BACKGROUND: The use of minimally invasive procedures in autopsies such as image-guided fine-needle aspiration may facilitate family acceptance and, therefore, increase the number of postmortem examinations. The objective of the current study was to validate the use of cytology in a prospective set of conventional autopsies. METHODS: All lesions and organs sampled for histological examination were concomitantly evaluated by scrape cytology of exactly the same location...
November 2016: Cancer Cytopathology
Poonam Vohra, Benjamin Buelow, Yunn-Yi Chen, Maria Serrano, Manjiv Singh Vohra, Anna Berry, Britt-Marie Ljung
BACKGROUND: Molecular analysis represents an increasingly important component of the pathologic examination of tumor specimens. Notably, the characterization of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression in breast cancer specimens provides critical prognostic and predictive information. The objective of the current study was to compare the concordance of these markers as determined on fine-needle aspiration (FNA) cell blocks compared with tissue blocks prepared from surgical specimens...
November 2016: Cancer Cytopathology
Hila Benjamin, Temima Schnitzer-Perlman, Alexander Shtabsky, Christopher J VandenBussche, Syed Z Ali, Zdenek Kolar, Fabio Pagni, Dganit Bar, Eti Meiri
BACKGROUND: The majority of thyroid nodules are diagnosed using fine-needle aspiration (FNA) biopsies. The authors recently described the clinical validation of a molecular microRNA-based assay, RosettaGX Reveal, which can diagnose thyroid nodules as benign or suspicious using a single stained FNA smear. This paper describes the analytical validation of the assay. METHODS: More than 800 FNA slides were tested, including slides stained with Romanowsky-type and Papanicolaou stains...
October 2016: Cancer Cytopathology
Rosemary H Tambouret
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
Zubair W Baloch, Raja R Seethala, William C Faquin, Mauro G Papotti, Fulvio Basolo, Guido Fadda, Gregory W Randolph, Steven P Hodak, Yuri E Nikiforov, Susan J Mandel
No abstract text is available yet for this article.
September 2016: Cancer Cytopathology
Kyuichi Kadota, Yumi Miyai, Naomi Katsuki, Yoshio Kushida, Toru Matsunaga, Masaya Okuda, Hiroyasu Yokomise, Nobuhiro Kanaji, Shuji Bandoh, Reiji Haba
BACKGROUND: In patients with resected non-small cell lung cancer (NSCLC), the prognostic value of nuclear grade has been demonstrated. However, among patients with advanced, unresectable NSCLC, the prognostic usefulness of cytological nuclear grade to the authors' knowledge remains unknown. In the current study, the authors used transbronchial cytology to investigate whether nuclear morphometry correlated with clinical outcomes in patients with advanced NSCLC. METHODS: The authors reviewed patients with advanced, unresectable NSCLC who were diagnosed on transbronchial cytology and were treated at the study institution from 2007 through 2015 (97 patients)...
September 2016: Cancer Cytopathology
Hoa V Pham, Liron Pantanowitz, Yang Liu
BACKGROUND: A definitive diagnosis of urothelial carcinoma in urine cytology is often challenging and subjective. Many urine cytology samples receive an indeterminate diagnosis. Ancillary techniques such as fluorescence in situ hybridization (FISH) have been used to improve the diagnostic sensitivity, but FISH is not approved as a routine screening test, and the complex fluorescent staining protocol also limits its widespread clinical use. Quantitative phase imaging (QPI) is an emerging technology allowing accurate measurements of the single-cell dry mass...
September 2016: Cancer Cytopathology
Mingjuan L Zhang, Alan X Guo, Christopher J VandenBussche
BACKGROUND: The Paris System for Reporting Urinary Cytology (TPS) has defined nuclear-to-cytoplasmic (N:C) ratio cutoff values for several of its risk-stratified diagnostic categories. However, because pathologists are not trained to recognize strict N:C ratio cutoff values, a previously designed survey was used to determine whether pathologists could accurately identify N:C ratios according to TPS standards. METHODS: Participants were instructed to estimate the N:C ratio of ideal (line drawing) and real (cell photograph) images presented via an online survey...
September 2016: Cancer Cytopathology
Eric J Yang, Jason L Hornick, Xiaohua Qian
BACKGROUND: Soft tissue perineurioma (STP) is a benign peripheral nerve sheath tumor demonstrating uniform perineurial cell differentiation. To the authors' knowledge, the cytomorphologic features of STP remain incompletely characterized, and the distinction between STP and its benign (intramuscular/cellular myxoma) and malignant (low-grade fibromyxoid sarcoma [LGFMS]) mimics is challenging. METHODS: Fine-needle aspiration (FNA)/core needle biopsies of 25 low-grade myxoid spindle cell neoplasm cases including STP (5 cases), intramuscular/cellular myxoma (16 cases), and LGFMS (4 cases) were reviewed retrospectively for cytomorphologic and immunophenotypic comparison...
September 2016: Cancer Cytopathology
Giuseppe Mancuso, Enrica Bovio, Ottavio Rena, Eltjona Rrapaj, Francesca Mercalli, Claudia Veggiani, Alessia Paganotti, Silvano Andorno, Renzo Boldorini
BACKGROUND: Small cell lung cancer (SCLC) is a highly aggressive neoplasm that accounts for approximately 10% to 15% of lung cancers. In most cases, the diagnosis relies on cytology and needs to be confirmed by immunohistochemistry. Although several genetic and molecular abnormalities have been recorded, molecular markers able to predict the prognosis are still lacking. MicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing...
September 2016: Cancer Cytopathology
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