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Cancer Cytopathology

Inga-Marie Schaefer, Jonathan A Fletcher, G Petur Nielsen, Angela R Shih, Marco L Ferrone, Jason L Hornick, Xiaohua Qian
BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific for GCT and chondroblastoma in surgical excisions. The objective of the current study was to validate H3G34W and H3K36M IHC in the diagnosis of giant cell-rich bone tumors on fine-needle aspiration and core needle biopsy specimens...
May 14, 2018: Cancer Cytopathology
Christopher J VandenBussche, Derek B Allison, Mohit Gupta, Syed Z Ali, Dorothy L Rosenthal
BACKGROUND: An important goal of The Paris System for Reporting Urinary Cytology (TPS) is to reduce unnecessary atypical diagnoses given to urinary tract cytology (UTC) specimens. Since implementation of TPS at the study institution in 2016, the institutional atypical rate has declined only slightly. The authors speculated that TPS might not have had an immediate impact because several faculty members were involved in TPS committees and because TPS contains elements that already had been integrated into institutional practice...
May 14, 2018: Cancer Cytopathology
Güliz A Barkan, Eva M Wojcik, Stefan E Pambuccian
No abstract text is available yet for this article.
May 14, 2018: Cancer Cytopathology
Vivian L Weiss, Rochelle F Andreotti, Kim A Ely
BACKGROUND: The American Thyroid Association (ATA) recommends fine-needle aspiration (FNA) biopsy of nodules measuring >1.5 cm with low-suspicion sonographic patterns or >1.0 cm with high/intermediate-suspicion features. Routine biopsy of nodules <1 cm is not recommended. However, despite these recommendations, subcentimeter nodules are often referred for FNA biopsy. METHODS: This was a retrospective chart review of consecutive thyroid FNAs during an 18-month period (1157 patients, 1491 nodules, 2016-2017) to evaluate age, sex, medical history, diagnoses, and follow-up...
May 7, 2018: Cancer Cytopathology
Julia L Manzo, Jackie Cuda, Liron Pantanowitz, Juan Xing, Jing Yu, H Scott Beasley, Rajiv Dhir, Sara E Monaco
BACKGROUND: After increased requests for biopsies for clinical trials and biomarker research, the University of Pittsburgh Medical Center created a clinical trial research service that partnered pathology, radiology, and medicine to facilitate rapid on-site evaluation (ROSE) of fine-needle aspiration (FNA) and/or core needle biopsy (CNB) samples to confirm the presence of tumor in these studies. METHODS: Clinical trial coordinators organized biopsies for patients needing tumor samples for trials, and informed the cytopathology and radiology team...
May 2, 2018: Cancer Cytopathology
Maria Gabriella Donà, Maria Benevolo, Alessandra Latini, Francesca Rollo, Manuela Colafigli, Mirko Frasca, Mauro Zaccarelli, Amalia Giglio, Domenico Moretto, Edoardo Pescarmona, Antonio Cristaudo, Massimo Giuliani
BACKGROUND: Anal cytology may be useful for evaluating lesions associated with human papillomavirus (HPV) in individuals at increased risk for anal cancer. METHODS: Liquid-based cytology was used to assess anal cytological lesions among human immunodeficiency virus (HIV)-infected and HIV-uninfected men who have sex with men (MSM). The Linear Array HPV genotyping test was used for HPV detection. RESULTS: This cross-sectional study included 1021 MSM, of whom 388 were HIV-infected (38...
April 25, 2018: Cancer Cytopathology
Shiva Kalidindi
No abstract text is available yet for this article.
April 23, 2018: Cancer Cytopathology
Katherine D Daly, Anuja S Mehta
No abstract text is available yet for this article.
April 18, 2018: Cancer Cytopathology
Haiyan Liu, Clarissa Ljungren, Fan Lin, Matthew A Zarka, Longwen Chen
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. The objective of this study was to assess the risk of malignancy (ROM) of NUMP. METHODS: A retrospective analysis was conducted on 656 salivary gland fine-needle aspiration specimens from 2010 to 2016...
April 18, 2018: Cancer Cytopathology
Stephen T C Wong
No abstract text is available yet for this article.
April 17, 2018: Cancer Cytopathology
Julie Meilleroux, Gwendoline Daniel, Jacqueline Aziza, Dominique M d'Aure, Marie-Laure Quintyn-Ranty, Céline Ml Basset, Solène M Evrard, Monique M Courtade-Saidi
BACKGROUND: The Paris System for Reporting Urinary Cytology (TPS) was published in November 2015. It focuses on the diagnosis of high-grade urothelial carcinoma (HGUC) and provides criteria with which to define the category of atypical urothelial cells (AUC). The objective of the current study was to compare two 1-year consecutive periods before and after use of TPS. METHODS: A total of 1634 and 1814 urine cytology cases, respectively, were analyzed before and after use of TPS...
April 17, 2018: Cancer Cytopathology
M Lisa Zhang, Ronald N Arpin, William R Brugge, David G Forcione, Omer Basar, Martha B Pitman
BACKGROUND: Making a specific diagnosis of pancreatic cysts preoperatively is difficult. The new disposable Moray micro forceps biopsy (MFB) device allows tissue sampling from the pancreatic cyst wall/septum and aims to improve diagnosis. This study compares the diagnostic performance of the MFB with the current conventional analysis of pancreatic cyst fluid (PCF). METHODS: A total of 48 patients sampled with MFB were identified. Cysts were classified as mucinous on PCF based on extracellular mucin/mucinous epithelium, carcinoembryonic antigen (CEA) levels ≥192 ng/mL, or KRAS/GNAS mutation...
April 16, 2018: Cancer Cytopathology
Rachel C Jug, Michael B Datto, Xiaoyin Sara Jiang
BACKGROUND: The ThyroSeq mutational panel and Afirma gene expression classifier (GEC) are used to risk stratify cytologically indeterminate thyroid nodules. In the current study, the authors evaluated the performance of these tests within the context of ultrasonographic features and with the incorporation of the noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) nomenclature. METHODS: The authors reviewed nodules using ThyroSeq or Afirma GEC testing...
April 10, 2018: Cancer Cytopathology
Athena L Chen, Andrew A Renshaw, William C Faquin, Erik K Alexander, Howard T Heller, Edmund S Cibas
BACKGROUND: A thyroid nodule comprised almost exclusively of mature, benign-appearing squamous cells is an uncommon finding in fine-needle aspiration (FNA) biopsies of thyroid nodules. Reporting such specimens was not originally addressed by The Bethesda System for Reporting Thyroid Cytopathology. The authors correlated the biologic behavior of the specimens with their benign cytologic appearance through clinical, radiographic, and surgical follow-up. METHODS: The pathology archives of 3 tertiary hospitals were searched for thyroid FNA specimens consisting of mature squamous cells without atypia...
April 10, 2018: Cancer Cytopathology
Kathryn S Dyhdalo, Deborah J Chute
BACKGROUND: The 2016 American Thyroid Association guidelines recommend multiple endocrine neoplasia testing and evaluation for pheochromocytoma before thyroidectomy after a thyroid fine-needle aspiration biopsy (FNA) is positive for medullary thyroid carcinoma (MTC). In the current study, the authors examined the reasons why FNA was unable to definitively diagnose MTC preoperatively, with attention to morphologic patterns that can be misleading. METHODS: Cases of MTC diagnosed on thyroid surgical resection for which there was a prior FNA and slides available for review were included (28 cases)...
March 26, 2018: Cancer Cytopathology
Amber L Smith, Michelle D Williams, John Stewart, Wei-Lien Wang, Savitri Krishnamurthy, Maria E Cabanillas, Sinchita Roy-Chowdhuri
BACKGROUND: The identification of BRAF mutations in thyroid cancer has prognostic and therapeutic implications. Although the gold standard for identifying BRAF mutations is molecular testing, the ability to perform BRAF p.V600E immunostaining on fine-needle aspiration (FNA) samples can facilitate the rapid triaging of patients to treatment options. METHODS: A total of 50 thyroid carcinoma FNA samples, including papillary (29 samples), poorly differentiated (10 samples), anaplastic (9 samples), and Hurthle cell (2 samples) carcinomas, with a known BRAF p...
March 26, 2018: Cancer Cytopathology
Johnathan M Hollyfield, Siobhan M O'Connor, Susan J Maygarden, Kevin G Greene, Lori R Scanga, Sherry Tang, Leslie G Dodd, Sara E Wobker
BACKGROUND: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has been proposed to standardize salivary gland fine-needle aspiration (FNA) diagnoses. This study assessed salivary gland FNA results and risk of malignancy (ROM) rates at the University of North Carolina as well as the interobserver reliability (IOR) of the atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP) categories. METHODS: The electronic medical record was searched for FNA cases from 2010 to 2017 with subsequent surgical resections...
March 26, 2018: Cancer Cytopathology
Barbara A Crothers
The author was the chair of a College of American Pathologists working group at the Gynecologic Cytopathology Quality Consensus Conference outlining then current practices in cytology-histology correlation, and published this work in the Archives of Pathology and Laboratory Medicine. Cancer Cytopathol 2018. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.
March 26, 2018: Cancer Cytopathology
Bryce Noll, Wei-Lien Wang, Yun Gong, Jun Zhao, Neda Kalhor, Victor Prieto, Gregg Staerkel, Sinchita Roy-Chowdhuri
BACKGROUND: Immune checkpoint inhibitors targeting the programmed cell death 1 (PD-1) receptor and its ligand, programmed death ligand 1 (PD-L1), have emerged as a therapeutic approach for patients with non-small cell lung carcinoma (NSCLC). PD-L1 expression, assessed by immunohistochemistry (IHC), is used to select patients for PD-1/PD-L1 inhibitor therapy. Most studies have been performed with histology specimens, with limited data available on the performance in cytology specimens...
March 2, 2018: Cancer Cytopathology
Bryn Nelson
No abstract text is available yet for this article.
April 2018: Cancer Cytopathology
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