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Biophysical Reviews

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https://www.readbyqxmd.com/read/28986860/correction-to-new-perspectives-in-nanotherapeutics-for-chronic-respiratory-diseases
#1
Adriana Lopes da Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Marcelo Marcos Morales
The original version of this article unfortunately contains an error. The third author's name "Patricia Rieken Macedo Rocco" was incorrectly spelled with "Roccco". The correct author name is now presented in the authorgroup.
October 6, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28986776/most-of-it-started-with-t4-phage-and-was-then-taken-over
#2
REVIEW
Shigeki Takeda
Professor Fumio Arisaka is one of the famous leaders in bacteriophage research, especially in the areas of protein biophysics and structural biology. Autonomous phage morphogenesis is a self-assembly process controlled by subunit-subunit interaction. Under this principle, Fumio has studied T4 tail assembly and morphology. He has also contributed structural information about T4 phage through a combination of X-ray structural analysis and three-dimensional image reconstruction using cryo-electron microscopy. Most of the development of ultracentrifugation applications for molecular assembly and phage morphogenesis research was also performed in Fumio's laboratory...
October 6, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28971326/plasma-treatments-of-dressings-for-wound-healing-a-review
#3
REVIEW
Nithya Eswaramoorthy, David R McKenzie
This review covers the use of plasma technology relevant to the preparation of dressings for wound healing. The current state of knowledge of plasma treatments that have potential to provide enhanced functional surfaces for rapid and effective healing is summarized. Dressings that are specialized to the needs of individual cases of chronic wounds such as diabetic ulcers are a special focus. A summary of the biology of wound healing and a discussion of the various types of plasmas that are suitable for the customizing of wound dressings are given...
October 2, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28944442/protein-folding-and-trna-biology
#4
REVIEW
Mónica Marín, Tamara Fernández-Calero, Ricardo Ehrlich
Polypeptides can fold into tertiary structures while they are synthesized by the ribosome. In addition to the amino acid sequence, protein folding is determined by several factors within the cell. Among others, the folding pathway of a nascent polypeptide can be affected by transient interactions with other proteins, ligands, or the ribosome, as well as by the translocation through membrane pores. Particularly, the translation machinery and the population of tRNA under different physiological or adaptive responses can dramatically affect protein folding...
September 24, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28940105/experimental-and-theoretical-studies-of-emodin-interacting-with-a-lipid-bilayer-of-dmpc
#5
REVIEW
Antonio R da Cunha, Evandro L Duarte, Hubert Stassen, M Teresa Lamy, Kaline Coutinho
Emodin is one of the most abundant anthraquinone derivatives found in nature. It is the active principle of some traditional herbal medicines with known biological activities. In this work, we combined experimental and theoretical studies to reveal information about location, orientation, interaction and perturbing effects of Emodin on lipid bilayers, where we have taken into account the neutral form of the Emodin (EMH) and its anionic/deprotonated form (EM(-)). Using both UV/Visible spectrophotometric techniques and molecular dynamics (MD) simulations, we showed that both EMH and EM(-) are located in a lipid membrane...
September 22, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28921106/kinetic-stability-of-membrane-proteins
#6
REVIEW
F Luis González Flecha
Although membrane proteins constitute an important class of biomolecules involved in key cellular processes, study of the thermodynamic and kinetic stability of their structures is far behind that of soluble proteins. It is known that many membrane proteins become unstable when removed by detergent extraction from the lipid environment. In addition, most of them undergo irreversible denaturation, even under mild experimental conditions. This process was found to be associated with partial unfolding of the polypeptide chain exposing hydrophobic regions to water, and it was proposed that the formation of kinetically trapped conformations could be involved...
September 18, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28921104/development-of-constant-ph-simulation-methods-in-implicit-solvent-and-applications-in-biomolecular-systems
#7
REVIEW
Fernando Luís Barroso daSilva, Luis Gustavo Dias
pH is a critical parameter for biological and technological systems directly related with electrical charges. It can give rise to peculiar electrostatic phenomena, which also makes them more challenging. Due to the quantum nature of the process, involving the forming and breaking of chemical bonds, quantum methods should ideally by employed. Nevertheless, due to the very large number of ionizable sites, different macromolecular conformations, salt conditions, and all other charged species, the CPU time cost simply becomes prohibitive for computer simulations, making this a quite complex problem...
September 18, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28917027/biophysics-in-latin-america
#8
EDITORIAL
Pietro Ciancaglini, Rosangela Itri
No abstract text is available yet for this article.
September 16, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28914424/new-perspectives-in-nanotherapeutics-for-chronic-respiratory-diseases
#9
Adriana Lopes da Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Marcelo Marcos Morales
According to the World Health Organization (WHO), hundreds of millions of people of all ages and in all countries suffer from chronic respiratory diseases, with particular negative consequences such as poor health-related quality of life, impaired work productivity, and limitations in the activities of daily living. Chronic obstructive pulmonary disease, asthma, occupational lung diseases (such as silicosis), cystic fibrosis, and pulmonary arterial hypertension are the most common of these diseases, and none of them are curable with current therapies...
September 15, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28905328/lessons-learned-from-protein-aggregation-toward-technological-and-biomedical-applications
#10
REVIEW
César L Avila, Silvina Chaves, Sergio B Socias, Esteban Vera-Pingitore, Florencia González-Lizárraga, Cecilia Vera, Diego Ploper, Rosana Chehín
The close relationship between protein aggregation and neurodegenerative diseases has been the driving force behind the renewed interest in a field where biophysics, neurobiology and nanotechnology converge in the study of the aggregate state. On one hand, knowledge of the molecular principles that govern the processes of protein aggregation has a direct impact on the design of new drugs for high-incidence pathologies that currently can only be treated palliatively. On the other hand, exploiting the benefits of protein aggregation in the design of new nanomaterials could have a strong impact on biotechnology...
September 13, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28905266/septin-structure-and-filament-assembly
#11
REVIEW
Napoleão Fonseca Valadares, Humberto d' Muniz Pereira, Ana Paula Ulian Araujo, Richard Charles Garratt
Septins are able to polymerize into long apolar filaments and have long been considered to be a component of the cytoskeleton alongside intermediate filaments (which are also apolar in nature), microtubules and actin filaments (which are not). Their central guanosine triphosphate (GTP)-binding domain, which is essential for stabilizing the filament itself, is flanked by N- and C-terminal domains for which no direct structural information is yet available. In most cases, physiological filaments are built from a number of different septin monomers, and in the case of mammalian septins this is most commonly either three or four...
September 13, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28889335/morphological-and-functional-diversity-of-first-order-somatosensory-neurons
#12
REVIEW
Eder Ricardo de Moraes, Christopher Kushmerick, Lígia Araujo Naves
First-order somatosensory neurons transduce and convey information about the external or internal environment of the body to the central nervous system. They are pseudo unipolar neurons with cell bodies residing in one of several ganglia located near the central nervous system, with the short branch of the axon connecting to the spinal cord or the brain stem and the long branch extending towards the peripheral organ they innervate. Besides their sensory transducer and conductive role, somatosensory neurons also have trophic functions in the tissue they innervate and participate in local reflexes in the periphery...
September 9, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28884448/conference-report-the-5th-asia-pacific-protein-association-conference-joint-meeting-with-the-12th-international-symposium-of-the-protein-society-of-thailand
#13
LETTER
James R Ketudat Cairns, Voraratt Champattanachai, Chantragan Srisomsap, N Monique Paricharttanakul, Chris Verathamjamras, Kriengsak Lirdprapamongkol, Jisnuson Svasti
No abstract text is available yet for this article.
September 7, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28884420/relation-between-biophysical-properties-of-nanostructures-and-their-toxicity-on-zebrafish
#14
REVIEW
C S Martinez, D E Igartúa, M N Calienni, D A Feas, M Siri, J Montanari, N S Chiaramoni, S Del V Alonso, M J Prieto
In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos...
September 7, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28871556/lessons-from-a-tarantula-new-insights-into-muscle-thick-filament-and-myosin-interacting-heads-motif-structure-and-function
#15
REVIEW
Lorenzo Alamo, Natalia Koubassova, Antonio Pinto, Richard Gillilan, Andrey Tsaturyan, Raúl Padrón
The tarantula skeletal muscle X-ray diffraction pattern suggested that the myosin heads were helically arranged on the thick filaments. Electron microscopy (EM) of negatively stained relaxed tarantula thick filaments revealed four helices of heads allowing a helical 3D reconstruction. Due to its low resolution (5.0 nm), the unambiguous interpretation of densities of both heads was not possible. A resolution increase up to 2.5 nm, achieved by cryo-EM of frozen-hydrated relaxed thick filaments and an iterative helical real space reconstruction, allowed the resolving of both heads...
September 4, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28871552/lessons-from-a-tarantula-new-insights-into-myosin-interacting-heads-motif-evolution-and-its-implications-on-disease
#16
REVIEW
Lorenzo Alamo, Antonio Pinto, Guidenn Sulbarán, Jesús Mavárez, Raúl Padrón
Tarantula's leg muscle thick filament is the ideal model for the study of the structure and function of skeletal muscle thick filaments. Its analysis has given rise to a series of structural and functional studies, leading, among other things, to the discovery of the myosin interacting-heads motif (IHM). Further electron microscopy (EM) studies have shown the presence of IHM in frozen-hydrated and negatively stained thick filaments of striated, cardiac, and smooth muscle of bilaterians, most showing the IHM parallel to the filament axis...
September 4, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28871493/plant-and-animal-aquaporins-crosstalk-what-can-be-revealed-from-distinct-perspectives
#17
REVIEW
Moira Sutka, Gabriela Amodeo, Marcelo Ozu
Aquaporins (AQPs) can be revisited from a distinct and complementary perspective: the outcome from analyzing them from both plant and animal studies. (1) The approach in the study. Diversity found in both kingdoms contrasts with the limited number of crystal structures determined within each group. While the structure of almost half of mammal AQPs was resolved, only a few were resolved in plants. Strikingly, the animal structures resolved are mainly derived from the AQP2-lineage, due to their important roles in water homeostasis regulation in humans...
September 4, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28853034/biophysical-and-biochemical-strategies-to-understand-membrane-binding-and-pore-formation-by-sticholysins-pore-forming-proteins-from-a-sea-anemone
#18
REVIEW
Carlos Alvarez, Uris Ros, Aisel Valle, Lohans Pedrera, Carmen Soto, Yadira P Hervis, Sheila Cabezas, Pedro A Valiente, Fabiola Pazos, Maria E Lanio
Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that are able to bind and oligomerize in membranes, leading to cell swelling, impairment of ionic gradients and, eventually, to cell death. In this review we summarize the knowledge generated from the combination of biochemical and biophysical approaches to the study of sticholysins I and II (Sts, StI/II), two actinoporins largely characterized by the Center of Protein Studies at the University of Havana during the last 20 years...
August 29, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28853007/lipid-packing-perturbation-of-model-membranes-by-ph-responsive-antimicrobial-peptides
#19
REVIEW
Dayane S Alvares, Taisa Giordano Viegas, João Ruggiero Neto
The indiscriminate use of conventional antibiotics is leading to an increase in the number of resistant bacterial strains, motivating the search for new compounds to overcome this challenging problem. Antimicrobial peptides, acting only in the lipid phase of membranes without requiring specific membrane receptors as do conventional antibiotics, have shown great potential as possible substituents of these drugs. These peptides are in general rich in basic and hydrophobic residues forming an amphipathic structure when in contact with membranes...
August 29, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28852989/biophysical-aspects-of-biomineralization
#20
REVIEW
Maytê Bolean, Ana M S Simão, Marina B Barioni, Bruno Z Favarin, Heitor G Sebinelli, Ekeveliny A Veschi, Tatiane A B Janku, Massimo Bottini, Marc F Hoylaerts, Rosangela Itri, José L Millán, Pietro Ciancaglini
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix (ECM) by promoting the synthesis of hydroxyapatite (HA) seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Several lipid and proteins present in the membrane of the MVs mediate the interactions of MVs with the ECM and regulate the initial mineral deposition and posterior propagation. Among the proteins of MV membranes, ion transporters control the availability of phosphate and calcium needed for initial HA deposition...
August 29, 2017: Biophysical Reviews
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