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Biophysical Reviews

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https://www.readbyqxmd.com/read/29909504/anderson-fabry-disease-in-heart-failure
#1
REVIEW
M M Akhtar, P M Elliott
Anderson-Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that result in deficiency of the enzyme alpha-galactosidase A. The worldwide incidence of Fabry's disease is reported to be in the range of 1 in 40,000-117,000, although this value may be a significant underestimate given under recognition of symptoms and delayed or missed diagnosis. Deficiency in alpha-galactosidase A causes an accumulation of neutral glycosphingolipids such as globotriaosylceramide (Gb3) in lysosomes within various tissues including the vascular endothelium, kidneys, heart, eyes, skin and nervous system...
June 16, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29876873/at-the-heart-of-inter-and-intracellular-signaling-the-intercalated-disc
#2
REVIEW
Heather R Manring, Lisa E Dorn, Aidan Ex-Willey, Federica Accornero, Maegen A Ackermann
Proper cardiac function requires the synchronous mechanical and electrical coupling of individual cardiomyocytes. The intercalated disc (ID) mediates coupling of neighboring myocytes through intercellular signaling. Intercellular communication is highly regulated via intracellular signaling, and signaling pathways originating from the ID control cardiomyocyte remodeling and function. Herein, we present an overview of the inter- and intracellular signaling that occurs at and originates from the intercalated disc in normal physiology and pathophysiology...
June 6, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29869751/actin-associated-proteins-and-cardiomyopathy-the-unknown-beyond-troponin-and-tropomyosin
#3
REVIEW
Elisabeth Ehler
It has been known for several decades that mutations in genes that encode for proteins involved in the control of actomyosin interactions such as the troponin complex, tropomyosin and MYBP-C and thus regulate contraction can lead to hereditary hypertrophic cardiomyopathy. In recent years, it has become apparent that actin-binding proteins not directly involved in the regulation of contraction also can exhibit changed expression levels, show altered subcellular localisation or bear mutations that might lead to hereditary cardiomyopathies...
June 5, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29869195/linker-of-nucleoskeleton-and-cytoskeleton-complex-proteins-in-cardiomyopathy
#4
REVIEW
Matthew J Stroud
The linker of nucleoskeleton and cytoskeleton (LINC) complex couples the nuclear lamina to the cytoskeleton. The LINC complex and its associated proteins play diverse roles in cells, ranging from genome organization, nuclear morphology, gene expression, to mechanical stability. The importance of a functional LINC complex is highlighted by the large number of mutations in genes encoding LINC complex proteins that lead to skeletal and cardiac myopathies. In this review, the structure, function, and interactions between components of the LINC complex will be described...
June 4, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29855812/understanding-amyloid-fibril-formation-using-protein-fragments-structural-investigations-via-vibrational-spectroscopy-and-solid-state-nmr
#5
REVIEW
Benjamin Martial, Thierry Lefèvre, Michèle Auger
It is well established that amyloid proteins play a primary role in neurodegenerative diseases. Alzheimer's, Parkinson's, type II diabetes, and Creutzfeldt-Jakob's diseases are part of a wider family encompassing more than 50 human pathologies related to aggregation of proteins. Although this field of research is thoroughly investigated, several aspects of fibrillization remain misunderstood, which in turn slows down, or even impedes, advances in treating and curing amyloidoses. To solve this problem, several research groups have chosen to focus on short fragments of amyloid proteins, sequences that have been found to be of great importance for the amyloid formation process...
May 31, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29754282/controlling-the-mechanoelasticity-of-model-biomembranes-with-room-temperature-ionic-liquids
#6
LETTER
Chiara Rotella, Pallavi Kumari, Brian J Rodriguez, Suzanne P Jarvis, Antonio Benedetto
Room-temperature ionic liquids (RTILs) are a vast class of organic non-aqueous electrolytes whose interaction with biomolecules is receiving great attention for potential applications in bio-nano-technology. Recently, it has been shown that RTILs dispersed at low concentrations at the water-biomembrane interface diffuse into the lipid region of the biomembrane, without disrupting the integrity of the bilayer structure. In this letter, we present the first exploratory study on the effect of absorbed RTILs on the mechanoelasticity of a model biomembrane...
May 12, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29725930/ionic-liquids-in-protein-amyloidogenesis-a-brief-screenshot-of-the-state-of-the-art
#7
LETTER
Visakh V S Pillai, Antonio Benedetto
Ionic liquids (ILs) are a vast class of organic non-aqueous electrolytes whose interaction with biomolecules is receiving great attention for potential applications in bio-nano-technology. Recently, it has been shown that ILs can affect protein amyloidogenesis. Whereas some ILs favour the aggregation of proteins into amyloids, others inhibit their formation. Moreover, ILs can dissolve mature fibrils and restore the protein biochemical function. In this letter, we present a brief state-of-the-art summary of this emerging field that holds the promise of important developments both in basic science and in applications from bio-medicine to material science, and bio-nano-technology...
May 3, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29611034/finding-cancer-driver-mutations-in-the-era-of-big-data-research
#8
REVIEW
Rebecca C Poulos, Jason W H Wong
In the last decade, the costs of genome sequencing have decreased considerably. The commencement of large-scale cancer sequencing projects has enabled cancer genomics to join the big data revolution. One of the challenges still facing cancer genomics research is determining which are the driver mutations in an individual cancer, as these contribute only a small subset of the overall mutation profile of a tumour. Focusing primarily on somatic single nucleotide mutations in this review, we consider both coding and non-coding driver mutations, and discuss how such mutations might be identified from cancer sequencing datasets...
April 2, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29611033/aqueous-ionic-liquids-in-comparison-with-standard-co-solutes-differences-and-common-principles-in-their-interaction-with-protein-and-dna-structures
#9
REVIEW
Ewa Anna Oprzeska-Zingrebe, Jens Smiatek
Ionic liquids (ILs) are versatile solvents for a broad range of biotechnological applications. Recent experimental and simulation results highlight the potential benefits of dilute ILs in aqueous solution (aqueous ILs) in order to modify protein and DNA structures systematically. In contrast to a limited number of standard co-solutes like urea, ectoine, trimethylamine-N-oxide (TMAO), or guanidinium chloride, the large amount of possible cation and anion combinations in aqueous ILs can be used to develop tailor-made stabilizers or destabilizers for specific purposes...
April 2, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29704212/recent-developments-in-biocatalysis-in-multiphasic-ionic-liquid-reaction-systems
#10
REVIEW
Lars-Erik Meyer, Jan von Langermann, Udo Kragl
Ionic liquids are well known and frequently used 'designer solvents' for biocatalytic reactions. This review highlights recent achievements in the field of multiphasic ionic liquid-based reaction concepts. It covers classical biphasic systems including supported ionic liquid phases, thermo-regulated multi-component solvent systems (TMS) and polymerized ionic liquids. These powerful concepts combine unique reaction conditions with a high potential for future applications on a laboratory and industrial scale...
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29700779/ionic-liquids-a-brief-history
#11
REVIEW
Tom Welton
There is no doubt that ionic liquids have become a major subject of study for modern chemistry. We have become used to ever more publications in the field each year, although there is some evidence that this is beginning to plateau at approximately 3500 papers each year. They have been the subject of several major reviews and books, dealing with different applications and aspects of their behaviours. In this article, I will show a little of how interest in ionic liquids grew and developed.
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29700778/editorial-of-the-ionic-liquids-and-biomolecules-special-issue
#12
EDITORIAL
Antonio Benedetto, Hans-Joachim Galla
No abstract text is available yet for this article.
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29696571/suppression-and-dissolution-of-amyloid-aggregates-using-ionic-liquids
#13
REVIEW
Takahiro Takekiyo, Yukihiro Yoshimura
Amyloid aggregates are composed of protein fibrils with a dominant β-sheet structure, are water-insoluble, and are involved in the pathogenesis of many neurodegenerative diseases. Development of pharmaceuticals to treat these diseases and the design of recovery agents for amyloid-type inclusion bodies require the successful suppression and dissolution of such aggregates. Since ionic liquids (ILs) are composed of both a cation and anion and are known to suppress protein aggregation and to dissolve water-insoluble compounds such as cellulose; they may also have potential use as suppression/dissolution agents for amyloid aggregates...
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29687273/designing-tailored-microbial-and-enzymatic-response-in-ionic-liquids-for-lignocellulosic-biorefineries
#14
LETTER
Seema Singh
No abstract text is available yet for this article.
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29687272/choline-amino-acid-ionic-liquids-past-and-recent-achievements-about-the-structure-and-properties-of-these-really-green-chemicals
#15
REVIEW
Lorenzo Gontrani
The structure of choline-amino acid ionic liquids, atoxic task-specific solvents composed of materials originated from renewable feedstocks, is reviewed in this letter. The varied and strong interactions that these liquids are capable of establishing are largely dependent on their structure and confer them outstanding solvating properties with respect to a large number of different solutes. Among the experimental methods capable of yielding structural insight, the energy-dispersive version of X-Ray diffraction, that uses the Bremsstrahlung radiation of the X-Ray tube, is a technique very well suited to investigate these liquid systems...
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29687271/biological-and-nanotechnological-applications-using-interactions-between-ionic-liquids-and-nucleic-acids
#16
REVIEW
Hisae Tateishi-Karimata, Naoki Sugimoto
Nucleic acids have emerged as powerful biological and nanotechnological tools. In biological and nanotechnological experiments, methods of extracting and purifying nucleic acids from various types of cells and their storage are critical for obtaining reproducible experimental results. In nanotechnological experiments, methods for regulating the conformational polymorphism of nucleic acids and increasing sequence selectivity for base pairing of nucleic acids are important for developing nucleic acid-based nanomaterials...
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29687270/computational-solvation-analysis-of-biomolecules-in-aqueous-ionic-liquid-mixtures-from-large-flexible-proteins-to-small-rigid-drugs
#17
REVIEW
Veronika Zeindlhofer, Christian Schröder
Based on their tunable properties, ionic liquids attracted significant interest to replace conventional, organic solvents in biomolecular applications. Following a Gartner cycle, the expectations on this new class of solvents dropped after the initial hype due to the high viscosity, hydrolysis, and toxicity problems as well as their high cost. Since not all possible combinations of cations and anions can be tested experimentally, fundamental knowledge on the interaction of the ionic liquid ions with water and with biomolecules is mandatory to optimize the solvation behavior, the biodegradability, and the costs of the ionic liquid...
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29654505/ionic-liquid-based-transmission-electron-microscopy-for-herpes-simplex-virus-type-1
#18
LETTER
Tetsuya Tsuda, Koshi Kawakami, Eiko Mochizuki, Susumu Kuwabata
No abstract text is available yet for this article.
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29654504/ken-seddon-obituary
#19
EDITORIAL
Tom Welton
No abstract text is available yet for this article.
June 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29546562/relaxation-mode-analysis-for-molecular-dynamics-simulations-of-proteins
#20
REVIEW
Ayori Mitsutake, Hiroshi Takano
Molecular dynamics simulation is a powerful method for investigating the structural stability, dynamics, and function of biopolymers at the atomic level. In recent years, it has become possible to perform simulations on time scales of the order of milliseconds using special hardware. However, it is necessary to derive the important factors contributing to structural change or function from the complicated movements of biopolymers obtained from long simulations. Although some analysis methods for protein systems have been developed using increasing simulation times, many of these methods are static in nature (i...
April 2018: Biophysical Reviews
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