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Chinese Journal of Cancer

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https://www.readbyqxmd.com/read/28427460/significance-of-spatial-organization-of-chromosomes-in-the-progression-of-acute-myeloid-leukemia
#1
LETTER
Xueli Tian, Yanfang Wang, Dieyan Chen, Xiaoyan Ke, Wanyun Ma
No abstract text is available yet for this article.
April 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28381242/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-15-24-edited-by-chinese-journal-of-cancer
#2
EDITORIAL
(no author information available yet)
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, 10 more questions are presented as follows. Question 15: Can tumor-induced erythrogenesis provide qualified red blood cells for carrying oxygen to distant organs? Question 16: Can we overcome tumor resistance to platinum-containing antineoplastic drugs by activating the sensitivity factors in the tumor? Question 17: How can a cancer cell stay dormant for years? Question 18: Why do cancer cells use distinct transcriptomic and proteomic programs to reach the same metastatic phenotype? Question 19: Why do some cancers regress spontaneously? Question 20: What are the regulatory mechanisms occurring in donor cells that determine selective sorting of biological content into vesicles and their biological consequences in recipient cells? Are the genetic transfer and exchange of biological messages between cells transient? Is the phenotypic manipulation of recipient cells temporary or prolonged and persistent? If extracellular vesicles possess immune-modulatory potential, how could they be exploited for immune interventions and cancer immunotherapy? Presumably the cargo of extracellular vesicles reflects the cells of their origin and can be used for cancer diagnosis, how could the uniform/stringent capture criteria be met universally for applying EVs in point-of-care diagnostics for cancer patients? Question 21: Can we use self-sampling technologies to monitor the tumor genetic alterations for more precise targeted therapy? Can we cure a heterogeneous tumor by sequentially targeting the driver molecules? Question 22: Can we postpone the onset of non-infection-related cancers? Question 23: How many types of cells can jointly form the tumor vasculature to provide blood supply for tumor progression? Question 24: How tumor cells transmit their epigenetic features to daughter cells and maintain the malignant phenotype?...
April 5, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28372569/cancer-metastasis-issues-and-challenges
#3
EDITORIAL
Chao-Nan Qian, Yan Mei, Jian Zhang
Metastasis is the major cause of treatment failure in cancer patients and of cancer-related deaths. This editorial discusses how cancer metastasis may be better perceived and controlled. Based on big-data analyses, a collection of 150 important pro-metastatic genes was studied. Using The Cancer Genome Atlas datasets to re-analyze the effect of some previously reported metastatic genes-e.g., JAM2, PPARGC1A, SIK2, and TRAF6-on overall survival of patients with renal and liver cancers, we found that these genes are actually protective factors for patients with cancer...
April 3, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28359295/rad51-inhibition-sensitizes-breast-cancer-stem-cells-to-parp-inhibitor-in-triple-negative-breast-cancer
#4
Dong Wang, Ruikai Du, Suling Liu
No abstract text is available yet for this article.
March 30, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28356139/tumor-microenvironment-driving-forces-and-potential-therapeutic-targets-for-breast-cancer-metastasis
#5
REVIEW
Hong-Yan Xie, Zhi-Min Shao, Da-Qiang Li
Distant metastasis to specific target organs is responsible for over 90% of breast cancer-related deaths, but the underlying molecular mechanism is unclear. Mounting evidence suggests that the interplay between breast cancer cells and the target organ microenvironment is the key determinant of organ-specific metastasis of this lethal disease. Here, we highlight new findings and concepts concerning the emerging role of the tumor microenvironment in breast cancer metastasis; we also discuss potential therapeutic intervention strategies aimed at targeting components of the tumor microenvironment...
March 29, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28356132/down-regulation-of-e-cadherin-enhances-prostate-cancer-chemoresistance-via-notch-signaling
#6
Wenchu Wang, Lihui Wang, Atsushi Mizokami, Junlin Shi, Chunlin Zou, Jinlu Dai, Evan T Keller, Yi Lu, Jian Zhang
BACKGROUND: The chemoresistance of prostate cancer (PCa) is invariably associated with the aggressiveness and metastasis of this disease. New emerging evidence indicates that the epithelial-to-mesenchymal transition (EMT) may play pivotal roles in the development of chemoresistance and metastasis. As a hallmark of EMT, E-cadherin is suggested to be a key marker in the development of chemoresistance. However, the molecular mechanisms underlying PCa chemoresistance remain unclear. The current study aimed to explore the association between EMT and chemoresistance in PCa as well as whether changing the expression of E-cadherin would affect PCa chemoresistance...
March 29, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28347331/progressive-multifocal-exophytic-pontine-glioblastoma-a-case-report-with-literature-review
#7
Fanfan Chen, Zongyang Li, Chengyin Weng, Peng Li, Lanbo Tu, Lei Chen, Wei Xie, Ling Li
Multifocal pontine glioblastoma exhibiting an exophytic growth pattern in the cerebello-pontine angle (CPA) is rare. We present a case of a 5-year-old girl with consecutive neurological imaging and other clinical findings indicating progressive multifocal exophytic pontine glioblastoma. Three lesions were reported, of which two were initially presented, and one was developed 2 months later. One lesion demonstrated a progressing exophytic extension in the cistern of the left side of the CPA. The other two lesions were located and confined within the pons...
March 27, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28347321/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-6-14-edited-by-chinese-journal-of-cancer
#8
EDITORIAL
(no author information available yet)
To accelerate our endeavors to overcome cancer, Chinese Journal of Cancer has launched a program of publishing 150 most important questions in cancer research and clinical oncology. In this article, nine more questions are presented as followed. Question 6. Why do nasopharyngeal carcinomas rarely metastasize to the brain? Question 7. Can distant spread of cancer cells be blocked by inhibiting the remodeling of high endothelial venules in the sentinel lymph node? Question 8. What sort of live-imaging techniques can be developed to directly observe the dynamic processes of metastasis? Question 9...
March 27, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28340596/clinical-treatment-considerations-in-the-intensity-modulated-radiotherapy-era-for-patients-with-n0-category-nasopharyngeal-carcinoma-and-enlarged-neck-lymph-nodes
#9
Hao Peng, Lei Chen, Rui Guo, Yuan Zhang, Wen-Fei Li, Yan-Ping Mao, Ying Sun, Fan Zhang, Li-Zhi Liu, Li Tian, Jun Ma
BACKGROUND: Nasopharyngeal carcinoma (NPC) shows a high proportion of lymph node metastasis, and treatment guidelines have been developed for positive nodes. However, no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes (ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph nodes. This study aimed to determine the prognostic value and radiation dose for ENLNs in N0-category NPC patients treated with intensity-modulated radiotherapy (IMRT)...
March 24, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28320486/left-jackknife-position-a-novel-position-for-laparoscopic-hepatectomy
#10
Jian-Cong Chen, Rong-Xin Zhang, Min-Shan Chen, Li Xu, Jin-Bin Chen, Ke-Li Yang, Yao-Jun Zhang, Zhong-Guo Zhou
BACKGROUND: Laparoscopic hepatectomy for hepatocellular carcinoma (HCC) located in segment VI, VII, or VIII of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment VI, VII, or VIII. METHODS: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife position...
March 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28314389/the-us-chinese-anti-cancer-association-and-the-asian-fund-for-cancer-research-recognize-young-chinese-cancer-researchers-with-the-2016-uscaca-afcr-scholar-awards
#11
EDITORIAL
Wei Zhang, Li Yan, Wei Zhang, Yunguang Tong, Shi-Yuan Cheng
No abstract text is available yet for this article.
March 17, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28292326/immune-mediators-in-the-tumor-microenvironment-of-prostate-cancer
#12
REVIEW
Jinlu Dai, Yi Lu, Hernan Roca, Jill M Keller, Jian Zhang, Laurie K McCauley, Evan T Keller
Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor...
March 14, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28279208/corepressor-metastasis-associated-protein-3-modulates-epithelial-to-mesenchymal-transition-and-metastasis
#13
REVIEW
Liang Du, Zhifeng Ning, Hao Zhang, Fuxing Liu
Worldwide, metastasis is the leading cause of more than 90% of cancer-related deaths. Currently, no specific therapies effectively impede metastasis. Metastatic processes are controlled by complex regulatory networks and transcriptional hierarchy. Corepressor metastasis-associated protein 3 (MTA3) has been confirmed as a novel component of nucleosome remodeling and histone deacetylation (NuRD). Increasing evidence supports the theory that, in the recruitment of transcription factors, coregulators function as master regulators rather than passive passengers...
March 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28270181/weekly-taxane-anthracycline-combination-regimen-versus-tri-weekly-anthracycline-based-regimen-for-the-treatment-of-locally-advanced-breast-cancer-a-randomized-controlled-trial
#14
Qiu-Wen Tan, Ting Luo, Hong Zheng, Ting-Lun Tian, Ping He, Jie Chen, He-Lin Zeng, Qing Lv
BACKGROUND: Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer. However, few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast cancer. This study was to compare the efficacy and safety of a weekly taxane-anthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast cancer. METHODS: Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide (FEC) regimen or weekly paclitaxel-epirubicin (PE) regimen...
March 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28264724/radiotherapy-with-neoadjuvant-chemotherapy-versus-concurrent-chemoradiotherapy-for-ascending-type-nasopharyngeal-carcinoma-a-retrospective-comparison-of-toxicity-and-prognosis
#15
Ji-Jin Yao, Xiao-Li Yu, Fan Zhang, Wang-Jian Zhang, Guan-Qun Zhou, Ling-Long Tang, Yan-Ping Mao, Lei Chen, Jun Ma, Ying Sun
BACKGROUND: In the era of intensity-modulated radiotherapy (IMRT), the role of neoadjuvant chemotherapy (NACT) in treating ascending-type nasopharyngeal carcinoma (NPC) is under-evaluated. This study was to compare the efficacy of NACT followed by IMRT (NACT + RT) with the efficacy of concurrent chemoradiotherapy (CCRT) on ascending-type NPC. METHODS: Clinical data of 214 patients with ascending-type NPC treated with NACT + RT or CCRT between December 2009 and July 2011 were analyzed...
March 6, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28257652/ailanthone-a-new-potential-drug-for-castration-resistant-prostate-cancer
#16
Shihong Peng, Zhengfang Yi, Mingyao Liu
No abstract text is available yet for this article.
March 3, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28245859/californium-252-neutron-brachytherapy-combined-with-external-pelvic-radiotherapy-plus-concurrent-chemotherapy-for-cervical-cancer-a-retrospective-clinical-study
#17
Shen Qian, Ling Ye, Yun-Hong Tian, Li-Gen Wang, Zuo-Ping Huang, Feng Li, Bing Hou, Ni Song, Juan Chen, Ying Liu, Xiao Liu, Tao Zhou
BACKGROUND: Cervical cancer is the sixth most common cancer in Chinese women. A standard treatment modality for cervical cancer is the combination of surgery, chemotherapy, external-beam radiotherapy and intracavitary brachytherapy. The aim of this study was to retrospectively assess the long-term treatment outcomes of patients with cervical cancer who were treated with californium-252 neutron brachytherapy combined with external-beam radiotherapy plus concurrent chemotherapy. METHODS: We retrospectively analyzed the medical records of 150 patients with primary stages IB-IVB cervical cancer who received neutron brachytherapy combined with external-beam radiotherapy concurrently with cisplatin chemotherapy...
February 28, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28241793/predictive-model-for-5-year-mortality-after-breast-cancer-surgery-in-taiwan-residents
#18
Su-Hsin Huang, Joon-Khim Loh, Jinn-Tsong Tsai, Ming-Feng Houg, Hon-Yi Shi
BACKGROUND: Few studies of breast cancer surgery outcomes have used longitudinal data for more than 2 years. This study aimed to validate the use of the artificial neural network (ANN) model to predict the 5-year mortality of breast cancer patients after surgery and compare predictive accuracy between the ANN model, multiple logistic regression (MLR) model, and Cox regression model. METHODS: This study compared the MLR, Cox, and ANN models based on clinical data of 3632 breast cancer patients who underwent surgery between 1996 and 2010...
February 27, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28228163/cell-cycle-independent-roles-of-p19-ink4d-in-human-terminal-erythropoiesis
#19
Xu Han, Jing Liu
No abstract text is available yet for this article.
February 23, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28187735/prognostic-value-of-alcohol-consumption-and-some-other-dietary-habits-for-survival-in-a-cohort-of-chinese-men-with-lung-cancer
#20
Wentao Li, Lap Ah Tse, Joseph S K Au, Kai Shing Yu, Feng Wang, Ignatius Tak-Sun Yu
BACKGROUND: Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge. METHODS: We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food...
February 10, 2017: Chinese Journal of Cancer
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