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Chinese Journal of Cancer

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https://www.readbyqxmd.com/read/28228163/cell-cycle-independent-roles-of-p19-ink4d-in-human-terminal-erythropoiesis
#1
Xu Han, Jing Liu
No abstract text is available yet for this article.
February 23, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28187735/prognostic-value-of-alcohol-consumption-and-some-other-dietary-habits-for-survival-in-a-cohort-of-chinese-men-with-lung-cancer
#2
Wentao Li, Lap Ah Tse, Joseph S K Au, Kai Shing Yu, Feng Wang, Ignatius Tak-Sun Yu
BACKGROUND: Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge. METHODS: We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food...
February 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28179026/proportion-and-clinical-features-of-never-smokers-with-non-small-cell-lung-cancer
#3
Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Dong-Wan Kim, Jae-Joon Yim, Young Tae Kim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
BACKGROUND: The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never-smokers with NSCLC in a large single institution. METHODS: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December 2014. RESULTS: Of the 1860 NSCLC patients, 707 (38...
February 8, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28143562/id4-promotes-cell-proliferation-in-hepatocellular-carcinoma
#4
Yang Zhang, Li-Xing Zhang, Xiao-Qin Liu, Fang-Yu Zhao, Chao Ge, Tao-Yang Chen, Ming Yao, Jin-Jun Li
BACKGROUND: Hepatocellular carcinoma (HCC) is a common malignant tumor in the world, especially in China. As a member of the inhibitor of differentiation (Id) family, Id4 has been reported to function in many cancer types, but relatively little is known about its role in HCC. The purpose of this study was to investigate the potential relationship between Id4 and HCC development and the underlying mechanism involving the function of Id4 in HCC. METHODS: We used quantitative real-time polymerase chain reaction and Western blotting to examine the RNA and protein expression of Id4...
February 1, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28143590/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-2-5-obesity-related-cancers-more-questions-than-answers
#5
EDITORIAL
Ajit Venniyoor
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers (ORCs) share a molecular signature? Are there common (over-lapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition...
January 31, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28126011/metformin-targets-multiple-signaling-pathways-in-cancer
#6
REVIEW
Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T Keller, Chao-Nan Qian, Jian Zhang, Yi Lu
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and nuclear factor kappaB pathways...
January 26, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28109319/for-robust-big-data-analyses-a-collection-of-150-important-pro-metastatic-genes
#7
REVIEW
Yan Mei, Jun-Ping Yang, Chao-Nan Qian
Metastasis is the greatest contributor to cancer-related death. In the era of precision medicine, it is essential to predict and to prevent the spread of cancer cells to significantly improve patient survival. Thanks to the application of a variety of high-throughput technologies, accumulating big data enables researchers and clinicians to identify aggressive tumors as well as patients with a high risk of cancer metastasis. However, there have been few large-scale gene collection studies to enable metastasis-related analyses...
January 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28103953/microwave-ablation-is-as-effective-as-radiofrequency-ablation-for-very-early-stage-hepatocellular-carcinoma
#8
Yun Xu, Qiang Shen, Neng Wang, Pan-Pan Wu, Bin Huang, Ming Kuang, Guo-Jun Qian
BACKGROUND: Percutaneous radiofrequency ablation (RFA) is a first-line treatment for very-early-stage hepatocellular carcinoma (HCC), whereas the efficacy of percutaneous microwave ablation (MWA) for very-early-stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very-early-stage HCC. METHODS: Clinical data of 460 patients who were diagnosed with very-early-stage HCC and treated with percutaneous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, in Shanghai, China were retrospectively analyzed...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28103919/prognostic-values-of-apoptosis-stimulating-p53-binding-protein-1-and-2-and-their-relationships-with-clinical-characteristics-of-esophageal-squamous-cell-carcinoma-patients-a-retrospective-study
#9
Xiao-Feng Xie, Qing Yang, Jun Chi, Xian-Zi Yang, Hui-Yun Wang, Guo-Liang Xu
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death, and new prognostic biomarkers are urgently needed. Apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) have been reported to play important roles in the development, progression, metastasis, and prognosis of cancers, but their roles in ESCC have not been elucidated. In this study, we examined the expression of ASPP1 and ASPP2 in ESCC to evaluate their prognostic values. METHODS: The protein expression of ASPP1, ASPP2, and P53 in 175 specimens of ESCC was detected using immunohistochemical staining; their expression in cancerous and noncancerous tissues was scored according to the staining intensity and the percentage of stained cells...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28093084/association-between-dna-mismatch-repair-gene-polymorphisms-and-platinum-based-chemotherapy-toxicity-in-non-small-cell-lung-cancer-patients
#10
Jun-Yan Liu, Chen-Yue Qian, Yuan-Feng Gao, Juan Chen, Hong-Hao Zhou, Ji-Ye Yin
BACKGROUND: Chemotherapy toxicity is a serious problem from which non-small cell lung cancer (NSCLC) patients suffer. The mismatch repair (MMR) system is associated with platinum-based chemotherapy toxicity in NSCLC patients. In this study, we aimed to investigate the relationship between genetic polymorphisms in the MMR pathway and platinum-based chemotherapy toxicity in NSCLC patients. METHODS: A total of 220 Chinese lung cancer patients who received at least two cycles of platinum-based chemotherapy were recruited for this study...
January 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28093081/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-1-could-the-vertical-transmission-of-human-papilloma-virus-hpv-infection-account-for-the-cause-characteristics-and-epidemiology-of-hpv-positive-oropharyngeal-carcinoma-non-smoking
#11
Joseph T S Wee, Sharon Shuxian Poh
Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries...
January 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28088228/the-loss-of-function-mutations-and-down-regulated-expression-of-asb3-gene-promote-the-growth-and-metastasis-of-colorectal-cancer-cells
#12
Wu-Ying Du, Zhen-Hai Lu, Wen Ye, Xiang Fu, Yi Zhou, Chun-Mei Kuang, Jiang-Xue Wu, Zhi-Zhong Pan, Shuai Chen, Ran-Yi Liu, Wen-Lin Huang
BACKGROUND: Ankyrin repeat and SOCS box protein 3 (ASB3) is a member of ASB family and contains ankyrin repeat sequence and SOCS box domain. Previous studies indicated that it mediates the ubiquitination and degradation of tumor necrosis factor receptor 2 and is likely involved in inflammatory responses. However, its effects on oncogenesis are unclear. This study aimed to investigate the effects of ASB3 on the growth and metastasis of colorectal cancer (CRC). METHODS: We used next-generation sequencing or Sanger sequencing to detect ASB3 mutations in CRC specimens or cell lines, and used real-time quantitative polymerase chain reaction, Western blotting, and immunohistochemical or immunofluorescence assay to determine gene expression...
January 14, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28086990/the-efficacy-of-fluoropyrimidine-based-adjuvant-chemotherapy-on-biliary-tract-cancer-after-r0-resection
#13
Young Saing Kim, Chi-Young Jeong, Haa-Na Song, Tae Hyo Kim, Hong Jun Kim, Young-Joon Lee, Soon Chan Hong
BACKGROUND: The optimal treatment strategy for biliary tract cancer (BTC) after curative-intent resection remains controversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine-based adjuvant chemotherapy for BTC patients undergoing microscopically margin-negative (R0) resection. METHODS: We retrospectively analyzed the clinical data of BTC patients who underwent curative-intent R0 resection. Patients were eligible if they received either fluoropyrimidine-based adjuvant chemotherapy or observation after R0 resection...
January 13, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28086948/is-there-still-a-role-for-cytotoxic-chemotherapy-after-targeted-therapy-and-immunotherapy-in-metastatic-melanoma-a-case-report-and-literature-review
#14
Aurélien Simon, Hampig Raphael Kourie, Joseph Kerger
Metastatic melanoma has long been considered to have a very poor prognosis and to be chemo-resistant. However, a subgroup of patients with metastatic melanoma presents remarkable responses to chemotherapeutic agents, even in the absence of a response to modern targeted therapies and immunotherapies; accordingly, determining predictive biomarkers of the response to chemotherapies for metastatic melanoma remains a priority to guide treatment in these patients. We report a case study of a patient with B-Raf proto-oncogene serine/threonine kinase-mutated metastatic melanoma harbouring many genetic mutations...
January 13, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28077159/concurrent-chemoradiotherapy-combined-with-enteral-nutrition-support-a-radical-treatment-strategy-for-esophageal-squamous-cell-carcinoma-patients-with-malignant-fistulae
#15
Li Ma, Guang-Yu Luo, Yu-Feng Ren, Bo Qiu, Hong Yang, Chun-Xia Xie, Song-Ran Liu, Shi-Liang Liu, Zhao-Lin Chen, Qun Li, Jian-Hua Fu, Meng-Zhong Liu, Yong-Hong Hu, Wen-Feng Ye, Hui Liu
BACKGROUND: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. METHODS: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012...
January 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28069048/effect-of-body-mass-index-on-survival-of-patients-with-stage-i-non-small-cell-lung-cancer
#16
Hao-Jun Xie, Xu Zhang, Zhen-Qiang Wei, Hao Long, Tie-Hua Rong, Xiao-Dong Su
BACKGROUND: Body mass index (BMI) has a U-shaped association with lung cancer risk. However, the effect of BMI on prognosis is controversial. This retrospective study aimed to investigate the effect of BMI on the survival of patients with stage I non-small cell lung cancer (NSCLC) after surgical resection. METHODS: In total, 624 consecutive stage I NSCLC patients who underwent radical resection were classified into four groups according to their BMI: underweight (BMI < 18...
January 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28069044/effect-of-transcutaneous-electrical-acupoint-stimulation-combined-with-palonosetron-on-chemotherapy-induced-nausea-and-vomiting-a-single-blind-randomized-controlled-trial
#17
Jing Xie, Lei-Hua Chen, Zhou-Yu Ning, Chen-Yue Zhang, Hao Chen, Zhen Chen, Zhi-Qiang Meng, Xiao-Yan Zhu
BACKGROUND: Chemotherapy-induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization (TACE). This study aimed to investigate the clinical effects of transcutaneous electrical acupoint stimulation (TEAS) on nausea and vomiting after TACE. METHODS: A total of 142 patients who received TACE with cisplatin for primary or metastatic liver cancer were assigned to the active-acupuncture (n = 72) or placebo-acupuncture (n = 70) groups using a covariate-adaptive randomization at a ratio of 1:1...
January 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28069069/arresting-kinase-suppressor-of-ras-in-an-inactive-state
#18
EDITORIAL
Syed Lal Badshah, Yahia Mabkhot
Ras protein signaling pathways are important in controlling the plight of different types of cancer. Here we discussed the paper entitled "Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling" published in Nature journal on inactivating the kinase suppressor of Ras (KSR) protein using a small molecule as an inhibitor by Dhawan et al. A biphenyl ether analogue of a quinazoline binds in one of the binding pockets of KSR and results in stabilization of its inactive state...
January 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28069055/novel-germline-mutations-in-flcn-gene-identified-in-two-chinese-patients-with-birt-hogg-dub%C3%A3-syndrome
#19
Teng Li, Xianghui Ning, Qun He, Kan Gong
Birt-Hogg-Dubé (BHD) syndrome, a hereditary renal cancer syndrome caused by mutations in the folliculin (FLCN) gene, is characterized by the presence of fibrofolliculomas, pulmonary cysts, spontaneous pneumothorax, and renal cell carcinoma (RCC). Few BHD syndrome cases have been reported in Asian countries, and cutaneous presentations are relatively rare in Asian patients. Asian BHD patients may be misdiagnosed due to their atypical manifestations. Here, we report two Chinese BHD patients with novel FLCN mutations (c...
January 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28063457/associations-of-lifestyle-and-diet-with-the-risk-of-nasopharyngeal-carcinoma-in-singapore-a-case-control-study
#20
Sook Kwin Yong, Tam Cam Ha, Ming Chert Richard Yeo, Valerie Gaborieau, James D McKay, Joseph Wee
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean population. METHODS: We conducted a case-control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012...
January 7, 2017: Chinese Journal of Cancer
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