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Chinese Journal of Cancer

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https://www.readbyqxmd.com/read/29228994/survival-and-prognostic-factors-of-non-small-cell-lung-cancer-patients-with-postoperative-locoregional-recurrence-treated-with-radical-radiotherapy
#1
Li Ma, Bo Qiu, Jun Zhang, Qi-Wen Li, Bin Wang, Xu-Hui Zhang, Meng-Yun Qiang, Zhao-Lin Chen, Su-Ping Guo, Hui Liu
BACKGROUND: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer (NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical radiotherapy. METHODS: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2012 and February 2016 at Sun Yat-sen University Cancer Center (Guangzhou, China)...
December 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29162161/international-szent-gy%C3%A3-rgyi-prize-for-progress-in-cancer-research-basic-and-translational-research-recognition-mary-claire-king-received-the-2016-prize-for-her-pioneering-research-that-demonstrated-the-first-evidence-of-genetic-predisposition-to-breast-cancer
#2
EDITORIAL
Hali Hartmann, Jie Zhao, Sujuan Ba
The Szent-Györgyi Prize for Progress in Cancer Research is a prestigious scientific award sponsored by the National Foundation for Cancer Research (NFCR)-a leading cancer research charitable organization in the United States that supports innovative cancer research globally with the ultimate goal to cure cancer. The coveted Szent-Györgyi Prize annually honors a scientist whose seminal discovery or body of work has resulted in, or led toward, notable contributions to cancer prevention, diagnosis, or treatment; and the discovery has had a high direct impact of saving people's lives...
November 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29151366/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-76-85-edited-by-chinese-journal-of-cancer
#3
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77. How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79...
November 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29122010/expression-of-voltage-gated-sodium-channel-nav1-5-in-non-metastatic-colon-cancer-and-its-associations-with-estrogen-receptor-er-%C3%AE-expression-and-clinical-outcomes
#4
Jianhong Peng, Qingjian Ou, Xiaojun Wu, Rongxin Zhang, Qian Zhao, Wu Jiang, Zhenhai Lu, Desen Wan, Zhizhong Pan, Yujing Fang
BACKGROUND: Voltage-gated sodium channel 1.5 (Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β (ER-β) expression in non-metastatic colon cancer patients receiving radical resection. METHODS: A total of 269 consecutive patients with pathologically confirmed stages I-III colon cancer who underwent radical resection were selected...
November 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29122009/nasopharyngeal-carcinoma-incidence-and-mortality-in-china-2013
#5
Kuang-Rong Wei, Rong-Shou Zheng, Si-Wei Zhang, Zhi-Heng Liang, Zhu-Ming Li, Wan-Qing Chen
BACKGROUND: We estimated the incidence and mortality of nasopharyngeal carcinoma (NPC) in China in 2010 according to the data of 145 domestic population-based cancer registries in 2014, and no such reports since then. Hence, to further and better understand its epidemiology in China and to provide more precise scientific information for its control and prevention in China, we analyzed the NPC incidence and mortality of 255 domestic population-based cancer registries, and estimated the national rates in 2013 again...
November 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29116024/systematic-analyses-of-glutamine-and-glutamate-metabolisms-across-different-cancer-types
#6
Yuan Tian, Wei Du, Sha Cao, Yue Wu, Ning Dong, Yan Wang, Ying Xu
BACKGROUND: Glutamine and glutamate are known to play important roles in cancer biology. However, no detailed information is available in terms of their levels of involvement in various biological processes across different cancer types, whereas such knowledge could be critical for understanding the distinct characteristics of different cancer types. Our computational study aimed to examine the functional roles of glutamine and glutamate across different cancer types. METHODS: We conducted a comparative analysis of gene expression data of cancer tissues versus normal control tissues of 11 cancer types to understand glutamine and glutamate metabolisms in cancer...
November 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29116021/prognostic-value-of-plasma-epstein-barr-virus-dna-level-during-posttreatment-follow-up-in-the-patients-with-nasopharyngeal-carcinoma-having-undergone-intensity-modulated-radiotherapy
#7
Wen-Fei Li, Yuan Zhang, Xiao-Bin Huang, Xiao-Jing Du, Ling-Long Tang, Lei Chen, Hao Peng, Rui Guo, Ying Sun, Jun Ma
BACKGROUND: The value of Epstein-Barr virus (EBV) DNA assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (NPC) presenting with different pretreatment plasma EBV DNA levels remains unclear. In the present study, we aimed to evaluate the prognostic value of plasma EBV DNA assay during posttreatment follow-up in the patients with NPC who have undergone intensity-modulated radiotherapy. METHODS: The medical records of 385 NPC patients treated with intensity-modulated radiotherapy between November 2009 and February 2012 were reviewed...
November 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29092716/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-67-75-edited-by-chinese-journal-of-cancer
#8
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Question 69...
November 1, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29084608/conditional-survival-in-patients-with-gallbladder-cancer
#9
Yi-Jun Kim, Kyubo Kim
BACKGROUND: Conditional survival (CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder (GB) cancer has not yet been fully evaluated. In this study, we evaluated the cancer-specific CS rate and cancer-specific survival (CSS) rate in patients with GB cancer at multiple time points and investigated prognostic factors which affect cancer-specific CS rate to provide more accurate survival information. METHODS: Between 2004 and 2013, a total of 9760 patients with GB cancer were identified from the Surveillance, Epidemiology, and End Results (SEER) data...
October 30, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29070080/the-influence-of-stage-at-diagnosis-and-molecular-subtype-on-breast-cancer-patient-survival-a-hospital-based-multi-center-study
#10
Tingting Zuo, Hongmei Zeng, Huichao Li, Shuo Liu, Lei Yang, Changfa Xia, Rongshou Zheng, Fei Ma, Lifang Liu, Ning Wang, Lixue Xuan, Wanqing Chen
BACKGROUND: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China. To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China. METHODS: All resident patients diagnosed with primary, invasive breast cancer between January 1, 2006 and December 31, 2010 from four selected hospitals in Beijing were included and followed up until December 31, 2015...
October 25, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29061175/hepatic-artery-infusion-chemotherapy-using-mfolfox-versus-transarterial-chemoembolization-for-massive-unresectable-hepatocellular-carcinoma-a-prospective-non-randomized-study
#11
Min-Ke He, Yong Le, Qi-Jiong Li, Zi-Shan Yu, Shao-Hua Li, Wei Wei, Rong-Ping Guo, Ming Shi
BACKGROUND: Transarterial chemoembolization (TACE) is recommended as the standard care for unresectable hepatocellular carcinoma (HCC) at Barcelona Clinic Liver Cancer (BCLC) stage A-B. However, the efficacy of TACE on large (≥ 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy (HAIC) might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX (mFOLFOX) regimen and those of TACE in patients with massive unresectable HCC...
October 23, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29037218/clinicopathologic-features-and-treatment-efficacy-of-chinese-patients-with-braf-mutated-metastatic-colorectal-cancer-a-retrospective-observational-study
#12
Xicheng Wang, Qing Wei, Jing Gao, Jian Li, Jie Li, Jifang Gong, Yanyan Li, Lin Shen
BACKGROUND: The prognostic role of the V600E mutation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in metastatic colorectal cancer (mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs. METHODS: We collected and reviewed the medical records of mCRC patients treated at Peking University Cancer Hospital & Institute (Beijing, China) between July 2011 and July 2016...
October 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29037212/chromatin-remodeling-factor-lymphoid-specific-helicase-inhibits-ferroptosis-through-lipid-metabolic-genes-in-lung-cancer-progression
#13
Yiqun Jiang, Yuchen He, Shuang Liu, Yongguang Tao
No abstract text is available yet for this article.
October 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29020982/the-prognostic-value-of-c-x-c-motif-chemokine-receptor-4-in-patients-with-sporadic-malignant-peripheral-nerve-sheath-tumors
#14
Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou, Ji-Long Yang
BACKGROUND: Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor (MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values...
October 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28974261/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-57-66-edited-by-chinese-journal-of-cancer
#15
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 10 more questions are presented as followed. Question 57. What are the major stresses that drive the formation, progression, and metastasis of a cancer? Question 58. What is the mechanism responsible for altering an acidic intracellular pH and a basic extracellular pH in normal tissue cells to a basic intracellular pH and an acidic extracellular pH in cancer cells, a fundamental and yet largely ignored phenomenon? Question 59...
October 3, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28969708/pathologic-response-after-preoperative-therapy-predicts-prognosis-of-chinese-colorectal-cancer-patients-with-liver-metastases
#16
Yun Wang, Yun-Fei Yuan, Hao-Cheng Lin, Bin-Kui Li, Feng-Hua Wang, Zhi-Qiang Wang, Pei-Rong Ding, Gong Chen, Xiao-Jun Wu, Zhen-Hai Lu, Zhi-Zhong Pan, De-Sen Wan, Peng Sun, Shu-Mei Yan, Rui-Hua Xu, Yu-Hong Li
BACKGROUND: Pathologic response is evaluated according to the extent of tumor regression and is used to estimate the efficacy of preoperative treatment. Several studies have reported the association between the pathologic response and clinical outcomes of colorectal cancer patients with liver metastases who underwent hepatectomy. However, to date, no data from Chinese patients have been reported. In this study, we aimed to evaluate the association between the pathologic response to pre-hepatectomy chemotherapy and prognosis in a cohort of Chinese patients...
October 2, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28950898/tripartite-motif-containing-3-trim3-inhibits-tumor-growth-and-metastasis-of-liver-cancer
#17
Xu-Qiong Huang, Xiao-Fei Zhang, Jin-Hua Xia, Jie Chao, Qiu-Zhong Pan, Jing-Jing Zhao, Zi-Qi Zhou, Chang-Long Chen, Yan Tang, De-Sheng Weng, Jian-Hua Zhang, Jian-Chuan Xia
BACKGROUND: Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma. In our previous research, we found that TRIM3 expression was markedly reduced in human primary hepatocellular carcinoma (HCC) tissues and that low TRIM3 expression was associated with short survival of HCC patients. However, the role of TRIM3 in liver cancer remains unknown. This study aimed to investigate the function of TRIM3 in liver cancer cells...
September 26, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28931426/effects-of-dosimetric-inadequacy-on-local-control-and-toxicities-in-the-patients-with-t4-nasopharyngeal-carcinoma-extending-into-the-intracranial-space-and-treated-with-intensity-modulated-radiotherapy-plus-chemotherapy
#18
Fen Xue, Chao-Su Hu, Xia-Yun He
BACKGROUND: To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we aimed to evaluate the effect of dosimetric inadequacy on local control and late neurological toxicities for patients treated with intensity-modulated radiotherapy (IMRT) plus chemotherapy. METHODS: We prospectively enrolled patients who had non-metastatic T4 NPC with intracranial extension treated between January 2009 and November 2013...
September 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28899420/prognostic-value-of-systemic-immune-inflammation-index-in-patients-with-gastric-cancer
#19
Kang Wang, Feiyu Diao, Zhijun Ye, Xinhua Zhang, Ertao Zhai, Hui Ren, Tong Li, Hui Wu, Yulong He, Shirong Cai, Jianhui Chen
BACKGROUND: Inflammation-based indexes have been used to predict survival and recurrence in cancer patients. Systemic immune-inflammation index (SII) was reported to be associated with prognosis in some malignant tumors. In the present study, we aimed to explore the association between SII and the prognosis of patients with gastric cancer. METHODS: We retrospectively analyzed data from 444 gastric cancer patients who underwent gastrectomy at the First Affiliated Hospital of Sun Yat-sen University between January 1994 and December 2005...
September 12, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28893309/efficacy-and-safety-of-controlled-release-oxycodone-naloxone-versus-controlled-release-oxycodone-in-korean-patients-with-cancer-related-pain-a-randomized-controlled-trial
#20
Kyung-Hee Lee, Tae Won Kim, Jung-Hun Kang, Jin-Soo Kim, Jin-Seok Ahn, Sun-Young Kim, Hwan-Jung Yun, Young-Jun Eum, Sung Ae Koh, Min Kyoung Kim, Yong Sang Hong, Jeong Eun Kim, Gyeong-Won Lee
BACKGROUND: Controlled-release oxycodone/naloxone (OXN-CR) maintains the effect of opioid-induced analgesia through oxycodone while reducing the occurrence rate of opioid-induced constipation through naloxone. The present study was designed to assess the non-inferiority of OXN-CR to controlled-release oxycodone (OX-CR) for the control of cancer-related pain in Korean patients. METHODS: In this randomized, open-labeled, parallel-group, phase IV study, we enrolled patients aged 20 years or older with moderate to severe cancer-related pain [numeric rating scale (NRS) pain score ≥4] from seven Korean oncology/hematology centers...
September 11, 2017: Chinese Journal of Cancer
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