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Chinese Journal of Cancer

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https://www.readbyqxmd.com/read/28320486/left-jackknife-position-a-novel-position-for-laparoscopic-hepatectomy
#1
Jian-Cong Chen, Rong-Xin Zhang, Min-Shan Chen, Li Xu, Jin-Bin Chen, Ke-Li Yang, Yao-Jun Zhang, Zhong-Guo Zhou
BACKGROUND: Laparoscopic hepatectomy for hepatocellular carcinoma (HCC) located in segment VI, VII, or VIII of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment VI, VII, or VIII. METHODS: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife position...
March 20, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28314389/the-us-chinese-anti-cancer-association-and-the-asian-fund-for-cancer-research-recognize-young-chinese-cancer-researchers-with-the-2016-uscaca-afcr-scholar-awards
#2
EDITORIAL
Wei Zhang, Li Yan, Wei Zhang, Yunguang Tong, Shi-Yuan Cheng
No abstract text is available yet for this article.
March 17, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28292326/immune-mediators-in-the-tumor-microenvironment-of-prostate-cancer
#3
REVIEW
Jinlu Dai, Yi Lu, Hernan Roca, Jill M Keller, Jian Zhang, Laurie K McCauley, Evan T Keller
Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor...
March 14, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28279208/corepressor-metastasis-associated-protein-3-modulates-epithelial-to-mesenchymal-transition-and-metastasis
#4
REVIEW
Liang Du, Zhifeng Ning, Hao Zhang, Fuxing Liu
Worldwide, metastasis is the leading cause of more than 90% of cancer-related deaths. Currently, no specific therapies effectively impede metastasis. Metastatic processes are controlled by complex regulatory networks and transcriptional hierarchy. Corepressor metastasis-associated protein 3 (MTA3) has been confirmed as a novel component of nucleosome remodeling and histone deacetylation (NuRD). Increasing evidence supports the theory that, in the recruitment of transcription factors, coregulators function as master regulators rather than passive passengers...
March 9, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28270181/weekly-taxane-anthracycline-combination-regimen-versus-tri-weekly-anthracycline-based-regimen-for-the-treatment-of-locally-advanced-breast-cancer-a-randomized-controlled-trial
#5
Qiu-Wen Tan, Ting Luo, Hong Zheng, Ting-Lun Tian, Ping He, Jie Chen, He-Lin Zeng, Qing Lv
BACKGROUND: Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer. However, few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast cancer. This study was to compare the efficacy and safety of a weekly taxane-anthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast cancer. METHODS: Patients with locally advanced breast cancer were randomized to receive 4-6 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil-epirubicin-cyclophosphamide (FEC) regimen or weekly paclitaxel-epirubicin (PE) regimen...
March 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28264724/radiotherapy-with-neoadjuvant-chemotherapy-versus-concurrent-chemoradiotherapy-for-ascending-type-nasopharyngeal-carcinoma-a-retrospective-comparison-of-toxicity-and-prognosis
#6
Ji-Jin Yao, Xiao-Li Yu, Fan Zhang, Wang-Jian Zhang, Guan-Qun Zhou, Ling-Long Tang, Yan-Ping Mao, Lei Chen, Jun Ma, Ying Sun
BACKGROUND: In the era of intensity-modulated radiotherapy (IMRT), the role of neoadjuvant chemotherapy (NACT) in treating ascending-type nasopharyngeal carcinoma (NPC) is under-evaluated. This study was to compare the efficacy of NACT followed by IMRT (NACT + RT) with the efficacy of concurrent chemoradiotherapy (CCRT) on ascending-type NPC. METHODS: Clinical data of 214 patients with ascending-type NPC treated with NACT + RT or CCRT between December 2009 and July 2011 were analyzed...
March 6, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28257652/ailanthone-a-new-potential-drug-for-castration-resistant-prostate-cancer
#7
Shihong Peng, Zhengfang Yi, Mingyao Liu
No abstract text is available yet for this article.
March 3, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28245859/californium-252-neutron-brachytherapy-combined-with-external-pelvic-radiotherapy-plus-concurrent-chemotherapy-for-cervical-cancer-a-retrospective-clinical-study
#8
Shen Qian, Ling Ye, Yun-Hong Tian, Li-Gen Wang, Zuo-Ping Huang, Feng Li, Bing Hou, Ni Song, Juan Chen, Ying Liu, Xiao Liu, Tao Zhou
BACKGROUND: Cervical cancer is the sixth most common cancer in Chinese women. A standard treatment modality for cervical cancer is the combination of surgery, chemotherapy, external-beam radiotherapy and intracavitary brachytherapy. The aim of this study was to retrospectively assess the long-term treatment outcomes of patients with cervical cancer who were treated with californium-252 neutron brachytherapy combined with external-beam radiotherapy plus concurrent chemotherapy. METHODS: We retrospectively analyzed the medical records of 150 patients with primary stages IB-IVB cervical cancer who received neutron brachytherapy combined with external-beam radiotherapy concurrently with cisplatin chemotherapy...
February 28, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28241793/predictive-model-for-5-year-mortality-after-breast-cancer-surgery-in-taiwan-residents
#9
Su-Hsin Huang, Joon-Khim Loh, Jinn-Tsong Tsai, Ming-Feng Houg, Hon-Yi Shi
BACKGROUND: Few studies of breast cancer surgery outcomes have used longitudinal data for more than 2 years. This study aimed to validate the use of the artificial neural network (ANN) model to predict the 5-year mortality of breast cancer patients after surgery and compare predictive accuracy between the ANN model, multiple logistic regression (MLR) model, and Cox regression model. METHODS: This study compared the MLR, Cox, and ANN models based on clinical data of 3632 breast cancer patients who underwent surgery between 1996 and 2010...
February 27, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28228163/cell-cycle-independent-roles-of-p19-ink4d-in-human-terminal-erythropoiesis
#10
Xu Han, Jing Liu
No abstract text is available yet for this article.
February 23, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28187735/prognostic-value-of-alcohol-consumption-and-some-other-dietary-habits-for-survival-in-a-cohort-of-chinese-men-with-lung-cancer
#11
Wentao Li, Lap Ah Tse, Joseph S K Au, Kai Shing Yu, Feng Wang, Ignatius Tak-Sun Yu
BACKGROUND: Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence. However, the effects of these habits on lung cancer prognosis have been studied rarely. The purpose of this study was to address these gaps in knowledge. METHODS: We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer. Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol, fresh fruits or vegetables, meat, and fried or preserved food...
February 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28179026/proportion-and-clinical-features-of-never-smokers-with-non-small-cell-lung-cancer
#12
Jaeyoung Cho, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Dong-Wan Kim, Jae-Joon Yim, Young Tae Kim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
BACKGROUND: The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never-smokers with NSCLC in a large single institution. METHODS: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December 2014. RESULTS: Of the 1860 NSCLC patients, 707 (38...
February 8, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28143562/id4-promotes-cell-proliferation-in-hepatocellular-carcinoma
#13
Yang Zhang, Li-Xing Zhang, Xiao-Qin Liu, Fang-Yu Zhao, Chao Ge, Tao-Yang Chen, Ming Yao, Jin-Jun Li
BACKGROUND: Hepatocellular carcinoma (HCC) is a common malignant tumor in the world, especially in China. As a member of the inhibitor of differentiation (Id) family, Id4 has been reported to function in many cancer types, but relatively little is known about its role in HCC. The purpose of this study was to investigate the potential relationship between Id4 and HCC development and the underlying mechanism involving the function of Id4 in HCC. METHODS: We used quantitative real-time polymerase chain reaction and Western blotting to examine the RNA and protein expression of Id4...
February 1, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28143590/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-2-5-obesity-related-cancers-more-questions-than-answers
#14
EDITORIAL
Ajit Venniyoor
Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobacco-related cancers are well characterized and effective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy (metabolically healthy obese, MHO), so which fat deposition (subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers (ORCs) share a molecular signature? Are there common (over-lapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse effect of obesity on human condition...
January 31, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28126011/metformin-targets-multiple-signaling-pathways-in-cancer
#15
REVIEW
Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T Keller, Chao-Nan Qian, Jian Zhang, Yi Lu
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and nuclear factor kappaB pathways...
January 26, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28109319/for-robust-big-data-analyses-a-collection-of-150-important-pro-metastatic-genes
#16
REVIEW
Yan Mei, Jun-Ping Yang, Chao-Nan Qian
Metastasis is the greatest contributor to cancer-related death. In the era of precision medicine, it is essential to predict and to prevent the spread of cancer cells to significantly improve patient survival. Thanks to the application of a variety of high-throughput technologies, accumulating big data enables researchers and clinicians to identify aggressive tumors as well as patients with a high risk of cancer metastasis. However, there have been few large-scale gene collection studies to enable metastasis-related analyses...
January 21, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28103953/microwave-ablation-is-as-effective-as-radiofrequency-ablation-for-very-early-stage-hepatocellular-carcinoma
#17
Yun Xu, Qiang Shen, Neng Wang, Pan-Pan Wu, Bin Huang, Ming Kuang, Guo-Jun Qian
BACKGROUND: Percutaneous radiofrequency ablation (RFA) is a first-line treatment for very-early-stage hepatocellular carcinoma (HCC), whereas the efficacy of percutaneous microwave ablation (MWA) for very-early-stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very-early-stage HCC. METHODS: Clinical data of 460 patients who were diagnosed with very-early-stage HCC and treated with percutaneous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, in Shanghai, China were retrospectively analyzed...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28103919/prognostic-values-of-apoptosis-stimulating-p53-binding-protein-1-and-2-and-their-relationships-with-clinical-characteristics-of-esophageal-squamous-cell-carcinoma-patients-a-retrospective-study
#18
Xiao-Feng Xie, Qing Yang, Jun Chi, Xian-Zi Yang, Hui-Yun Wang, Guo-Liang Xu
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death, and new prognostic biomarkers are urgently needed. Apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) have been reported to play important roles in the development, progression, metastasis, and prognosis of cancers, but their roles in ESCC have not been elucidated. In this study, we examined the expression of ASPP1 and ASPP2 in ESCC to evaluate their prognostic values. METHODS: The protein expression of ASPP1, ASPP2, and P53 in 175 specimens of ESCC was detected using immunohistochemical staining; their expression in cancerous and noncancerous tissues was scored according to the staining intensity and the percentage of stained cells...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28093084/association-between-dna-mismatch-repair-gene-polymorphisms-and-platinum-based-chemotherapy-toxicity-in-non-small-cell-lung-cancer-patients
#19
Jun-Yan Liu, Chen-Yue Qian, Yuan-Feng Gao, Juan Chen, Hong-Hao Zhou, Ji-Ye Yin
BACKGROUND: Chemotherapy toxicity is a serious problem from which non-small cell lung cancer (NSCLC) patients suffer. The mismatch repair (MMR) system is associated with platinum-based chemotherapy toxicity in NSCLC patients. In this study, we aimed to investigate the relationship between genetic polymorphisms in the MMR pathway and platinum-based chemotherapy toxicity in NSCLC patients. METHODS: A total of 220 Chinese lung cancer patients who received at least two cycles of platinum-based chemotherapy were recruited for this study...
January 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28093081/the-most-important-questions-in-cancer-research-and-clinical-oncology-question-1-could-the-vertical-transmission-of-human-papilloma-virus-hpv-infection-account-for-the-cause-characteristics-and-epidemiology-of-hpv-positive-oropharyngeal-carcinoma-non-smoking
#20
Joseph T S Wee, Sharon Shuxian Poh
Specific research foci: (1) Mouse models of gamma-herpes virus-68 (γHV-68) and polyomavirus (PyV) infections during neonatal versus adult life. (2) For human papilloma virus (HPV)-positive oropharyngeal carcinoma (OPC)-(a) Asking the question: Is oral sex a powerful carcinogen? (b) Examining the evidence for the vertical transmission of HPV infection. (c) Examining the relationship between HPV and Epstein-Barr virus (EBV) infections and nasopharyngeal cancer (NPC) in West European, East European, and East Asian countries...
January 16, 2017: Chinese Journal of Cancer
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