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Journal of Evidence-based Medicine

Chengwu Jin, Xiangbing Deng, Yan Li, Wanbin He, Xuyang Yang, Jian Liu
OBJECTIVE: With neoadjuvant therapy increasingly used in advanced rectal cancer, the lymph node ratio (LNR) has been strongly considered to indicate cancer-specific survival in recent years, and a comprehensive evaluation of a large number of studies is deficient. The objective of our study is to pool enough eligible studies to assess the relationship between LNR and prognosis of advanced rectal cancer after neoadjuvant therapy. METHODS: A systematic search was done in the PubMed and EmBase databases (through 1 March 2017) that reported LNR in colorectal cancer after neoadjuvant therapy...
July 11, 2018: Journal of Evidence-based Medicine
Yali Fu, Shuwei Zha, Nianqing Lü, Haoqin Xu, Xuening Zhang, Wenhui Shi, Ji Zha
OBJECTIVE: The objective of this study was to review the carrier frequencies of hearing loss gene variants, such as GJB2, SLC26A4, and MT-RNR1 in newborns of China. DESIGN: PubMed, Embase, BioCentral, CNKI, WanFang, and VIP databases were used for searching relevant literature studies published during the period of January 2007 and January 2016. Meta-analysis was performed by using the R software. The estimated rate and its 95% confidence intervals (CI) of the relevant indexes in newborns were collected and calculated using a fixed-effects model or a random-effects model when appropriate...
July 2, 2018: Journal of Evidence-based Medicine
Astrid Austvoll-Dahlgren, Marit Johansen
BACKGROUND: Shared decision-making is a central element of evidence-based practice (EBP). Training in EBP has traditionally focused on providers, but there is an increasing interest in developing such educational resources for patients. The aim of this study is to explore the views of patient representatives attending a workshop in EBP. METHODS: We conducted three focus groups with participants attending EBP workshops in 2013, 2014, and 2015. We used the framework method for content analysis...
June 25, 2018: Journal of Evidence-based Medicine
Wenwen Chen, Jiajie Yu, Huan Tao, Yujia Cai, Youping Li, Xin Sun
OBJECTIVE: To assess the impact of motherwort injection alone or combined with oxytocin for preventing postpartum hemorrhage in pregnant women with caesarean section. METHODS: A systematic review and meta-analysis of randomized trials were performed. PubMed, EMbase, The Cochrane Central Register of Controlled Trials (CENTRAL), Chinese database Sino-Med, Chinese National Knowledge Infrastructure Database (CNKI), VIP Chinese Science and Technique Journals Database, WanFang, and ClinicalTrials...
June 7, 2018: Journal of Evidence-based Medicine
Daniel Erlewein, Tommaso Bruni, Mariacarla Gadebusch Bondio
OBJECTIVE: In 1983, McIntyre and Popper underscored the need for more openness in dealing with errors in medicine. Since then, much has been written on individual medical errors. Furthermore, at the beginning of the 21st century, researchers and medical practitioners increasingly approached individual medical errors through health information technology. Hence, the question arises whether the attention of biomedical researchers shifted from individual medical errors to health information technology...
June 7, 2018: Journal of Evidence-based Medicine
Atefeh Ghanbari, Pardis Rahmatpour, Fateme Jafaraghaee, Ehsan Kazemnejad, Malahat Khalili
OBJECTIVE: Nurses play an effective role in diabetic foot care and they should know the best evidence. In this way, implementations according evidence-based clinical practice guidelines have positive effects on nurses' practice and patient outcomes. The objective of this study was quality assessment of diabetic foot ulcer clinical practice guidelines. METHODS: Evidence about nursing care in diabetic foot ulcer in last 5 years was searched and categorized based on nursing diagnosis (ND) and evidence levels and was finally designed as a guideline...
June 7, 2018: Journal of Evidence-based Medicine
Frank Peinemann, Alexander Michael Labeit
OBJECTIVE: Proper interpretation of survival data of clinical cancer studies may be difficult and pitfalls related to the nature of Kaplan-Meier analyses might end up in mistaken inferences. The purpose of the present work is to raise awareness of those pitfalls and to prevent errors in future studies. STUDY DESIGN AND SETTING: While evaluating a randomized controlled trial, we came across some issues possibly associated with misinterpreting survival data. We thoroughly reviewed the reporting of survival analyses, statistical approaches, baseline characteristics, and choice of primary end point...
June 6, 2018: Journal of Evidence-based Medicine
Ariel R Choi, Paul B Greenberg
OBJECTIVE: To systematically review the comparative effectiveness of patient education strategies in cataract surgery. METHODS: A comprehensive literature search of five electronic databases was conducted for randomized controlled trials (RCTs) studying the efficacy of educational interventions for cataract surgery patients. Peer-reviewed articles published in English were considered for inclusion without restriction limits on publication date. General study characteristics, measurement methodologies, and outcome measures were narratively synthesized...
May 2018: Journal of Evidence-based Medicine
Beatriz Nistal-Nuño
Unpredictability arises in numerous real-world implementations especially in medical fields, being one of the principal subjects that expert systems have to deal with. Bayesian networks (BNs) allow constructing expert systems by utilizing likelihood as a measure of uncertainty. A BN is a statistical model that yields a graphical description of the probabilistic associations between a group of pertinent variables. Probabilistic reasoning involves computing the posterior probability of the unobserved variables given the accessible evidence, based on the application of the Bayes theorem...
May 2018: Journal of Evidence-based Medicine
Luis C L Correia, Vitor C A Correia, Thiago M B Souza, Antonio Maurício S Cerqueira, Felipe K B Alexandre, Guilherme Garcia, Felipe R M Ferreira, Fernanda O A Lopes
OBJECTIVE: To assess review articles on pragmatic trials in order to describe how authors define the aim of this type of study, how comprehensive methodological topics are covered, and which topics are most valued by authors. METHODS: Review articles were selected from Medline Database, based on the expression "pragmatic trial" in the titles. Five trained medical students evaluated the articles, based on a list of 15 self-explanatory methodological topics...
May 2018: Journal of Evidence-based Medicine
Jie Zhang, Taiqiang Zhao, Chengjie Xu, Hua Yu
OBJECTIVE: IL-22 plays an important role in cancer carcinogenesis. However, the association between IL-22 polymorphisms and cancer risk was inconclusive. The objective of the current study was to assess these associations by meta-analysis. METHODS: PubMed, EMbase, CNKI, VIP, and Wanfang databases were searched up to 31 January 2018. The results were screened according to the inclusion and exclusion criteria. The associations between polymorphisms and cancer risk were estimated by meta-analysis...
May 2018: Journal of Evidence-based Medicine
Dongbo Wu, Wei Jiang, Le Yu, Yonghong Wang, Yachao Tao, Hong Tang, Enqiang Chen
AIM: We aimed to appraise the quality of Chinese Society of Infectious Diseases of China Medical Association clinical practice guidelines (CPGs) for infectious diseases in China. METHODS: We performed the electronic search and hand search on the above-mentioned CPGs for infectious diseases published from January 1997 to October 2017. Each publication was evaluated using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. RESULTS: Thirteen guidelines were identified and enrolled for the further evaluation...
May 2018: Journal of Evidence-based Medicine
Viswas Chhapola, Soumya Tiwari, Rekha Brar, Sandeep Kumar Kanwal
OBJECTIVES: We conducted a systematic review and meta-analysis of literature to determine if the publication of the Consolidated Standards of Reporting Trials (CONSORT) abstract guideline in 2008 was followed by change in reporting quality of randomized controlled trial (RCT) abstracts. STUDY DESIGN AND SETTINGS: Evaluations were included if they compared reporting quality of RCT abstracts before and after the publication of CONSORT-abstract guideline. The literature search was performed (January 2008 to April 2017) in Medline (Ovid), EMbase, CINAHL plus and Cochrane methodologies register...
May 2018: Journal of Evidence-based Medicine
Chao Zhang, Pengli Jia, Liu Yu, Chang Xu
OBJECTIVE: Dose-response meta-analysis (DRMA) is widely applied to investigate the dose-specific relationship between independent and dependent variables. Such methods have been in use for over 30 years and are increasingly employed in healthcare and clinical decision-making. In this article, we give an overview of the methodology used in DRMA. METHODS: We summarize the commonly used regression model and the pooled method in DRMA. We also use an example to illustrate how to employ a DRMA by these methods...
May 2018: Journal of Evidence-based Medicine
Yana Qi, Chuan Yu, Li Tang, Sheyu Li, Xin Sun
OBJECTIVE: To explore patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina. METHODS: An analysis was conducted of data from a multicenter, phase IV clinical trial undertaken in China that enrolled 2150 patients hospitalized for stable angina from 50 hospitals. The treatment outcomes were changes of angina severity and nitroglycerin use between baseline and the last day of treatment. We used logistic regression models to explore patient characteristics associated with the treatment response...
May 2018: Journal of Evidence-based Medicine
Sheyu Li, Chuan Yu, Yun Li, Qianrui Li, Rui Zhang, Qingtao Hou, Tao Zheng, Yi Ma, Miye Wang, Na Su, Ting Wu, Zhiwen Liu, Xia Sheng, Nan Li, Guanjian Liu, Yong Huang, Ting Xu, Xin Sun, Haoming Tian
AIM: To describe the characteristics of inpatients with diabetes in a tertiary hospital in China using an electronic medical record (EMR)-based database. METHODS: We identified the medical records of all patients with diabetes from nonpediatric departments of West China Hospital, Sichuan University (from February 2009 to December 2013), and extracted information on demographic, diagnosis, discharge outcome, department of discharge, laboratory test, and prescription from the EMR system...
March 7, 2018: Journal of Evidence-based Medicine
Joey S W Kwong, Youping Li, Mingming Zhang
No abstract text is available yet for this article.
February 2018: Journal of Evidence-based Medicine
Xian-Tao Zeng, Tong-Zu Liu, Kan Gong, Da-Lin He, Xing-Huan Wang
Bladder cancer and benign prostatic hyperplasia have been two very common diseases among the elderly men, especially with the aging of the population in the world. We have designed a study to investigate the clinical effect of interventional therapy for plasmakinetic resection of the prostate and plasmakinetic resection of the bladder, which is called "BPSC" (The bladder cancer and benign prostatic hyperplasia study in Chinese population). The BPSC is not only a specific study, it is made up of many studies...
February 2018: Journal of Evidence-based Medicine
Chen Yao
No abstract text is available yet for this article.
February 2018: Journal of Evidence-based Medicine
Xuelei Ma, Hao Zeng, Jing Zhang, Linyan Chen, Hongyuan Jia
AIM: Found some new methods that can be used to obtain values such as true positives (TP), false negatives (FN), false positives (FP), and true negatives (TN) which did not provide in diagnostic meta-analysis indirectly. METHODS: Using mathematical deduction and programming calculus. RESULTS: We have succeeded in increasing the number of articles that can be used from two(228 patients) to five(469 patients) by using our new method. CONCLUSION: Using these methods, it can greatly increase the number of the inclusion articles, as well as the number of inclusion patients, which will contribute to improve the persuasiveness and comprehensiveness of diagnostic meta-analysis...
February 2018: Journal of Evidence-based Medicine
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