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Advances in Protein Chemistry and Structural Biology

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https://www.readbyqxmd.com/read/29680245/preface
#1
EDITORIAL
Rossen Donev
No abstract text is available yet for this article.
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680244/dynamical-behavior-of-somatostatin-14-and-its-cyclic-analogues-as-analyzed-in-bulk-and-on-plasmonic-silver-nanoparticles
#2
Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G Kruglik, Régis Cohen, Mahmoud Ghomi
Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herein, after recalling the main somatostatin therapeutic interests, we present the dynamical behavior of somatostatin-14 and its two currently used synthetic cyclic analogues, octreotide and pasireotide...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680243/therapeutic-monoclonal-antibodies-delivery-for-the-glioblastoma-treatment
#3
Flávia Sousa, Rui P Moura, Elias Moreira, Cláudia Martins, Bruno Sarmento
Glioblastoma multiforme (GBM) is the most common and challenging primary malignant brain tumor, being the median overall survival between 10 and 14 months due to its invasive characteristics. GBM treatment is mainly based on the maximal surgical resection and radiotherapy associated to chemotherapy. Monoclonal antibodies (mAbs) have been used in chemotherapy protocols for GBM treatment in order to improve immunotherapy and antiangiogenic processes. High specificity and affinity of mAbs for biological targets make them highly used for brain tumor therapy...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680242/linear-analogues-of-the-lipopeptide-battacin-with-potent-in-vitro-activity-against-s-aureus
#4
Hugh D Glossop, Esperanza Pearl, Gayan H De Zoysa, Vijayalekshmi Sarojini
Eight linear analogues of the lipopeptide battacin were evaluated for their antibacterial activity against the Gram-positive Staphylococcus aureus. Of this library, the enantiomeric lipopeptide analogue 9.4 exhibited nanomolar inhibitory activity (MIC=200nmol) against S. aureus. Furthermore, this lipopeptide was resilient toward degradation conditions when exposed to rat serum proteases for up to 8h.
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680241/the-structure-function-relationship-in-antimicrobial-peptides-what-can-we-obtain-from-structural-data
#5
Marlon H Cardoso, Karen G N Oshiro, Samilla B Rezende, Elizabete S Cândido, Octávio L Franco
Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and hydrophobic moment. It is known that such properties may be directly associated with AMPs' structural arrangements and, consequently, could interfere in their modes of action against microorganisms. In this scenario, biophysical methodologies, such as nuclear magnetic resonance spectroscopy, X-ray crystallography, and cryo-electron microscopy, allied to in silico approaches, including molecular modeling, docking, and dynamics nowadays represent an enormous first step for the structural elucidation of AMPs, leading to further structure-function annotation...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680240/peptide-derivatives-of-erythropoietin-in-the-treatment-of-neuroinflammation-and-neurodegeneration
#6
Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc
During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect of EPO could not be translated to the clinical trials because of common lethal thromboembolic events, erythropoiesis and hypertension...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680239/protein-and-peptides-for-elderly-health
#7
Nan Shang, Chalamaiah Meram, Nandika Bandara, Jianping Wu
The world is aging rapidly; thus, the management of elderly health at an advanced age poses a new research challenge. The elderly is vulnerable to not only malnutrition but also hypofunction of all organs and a variety of chronic diseases such as sarcopenia, osteoporosis, gastrointestinal dysfunction, and mental problems. As the major macronutrient, food protein plays an important role in elderly health and well-being. In this chapter, the function of protein and peptide in elderly health as well as their effects on preventing aging-related disease is reviewed...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680238/in-silico-tools-and-databases-for-designing-peptide-based-vaccine-and-drugs
#8
Salman Sadullah Usmani, Rajesh Kumar, Sherry Bhalla, Vinod Kumar, Gajendra P S Raghava
The prolonged conventional approaches of drug screening and vaccine designing prerequisite patience, vigorous effort, outrageous cost as well as additional manpower. Screening and experimentally validating thousands of molecules for a specific therapeutic property never proved to be an easy task. Similarly, traditional way of vaccination includes administration of either whole or attenuated pathogen, which raises toxicity and safety issues. Emergence of sequencing and recombinant DNA technology led to the epitope-based advanced vaccination concept, i...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680237/smart-cell-penetrating-peptide-based-techniques-for-intracellular-delivery-of-therapeutic-macromolecules
#9
Yang He, Feng Li, Yongzhuo Huang
Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportation into target cells. Therefore, efficient intracellular delivery of these macromolecules is critical for improving their therapeutic efficacy. Cell-penetrating peptide (CPP)-based approaches are one of the most efficient methods for intracellular delivery of macromolecular therapeutics. Nevertheless, poor specificity is a significant concern for systemic administrated CPP-based delivery systems...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680236/chimeric-small-antibody-fragments-as-strategy-to-deliver-therapeutic-payloads
#10
Sandra Aguiar, Joana Dias, Ana M Manuel, Roberto Russo, Pedro M P Gois, Frederico A da Silva, Joao Goncalves
Antibody-drug conjugates (ADCs) represent an innovative class of biopharmaceuticals, which aim at achieving a site-specific delivery of cytotoxic agents to the target cell. The use of ADCs represents a promising strategy to overcome the disadvantages of conventional pharmacotherapy of cancer or neurological diseases, based on cytotoxic or immunomodulatory agents. ADCs consist of monoclonal antibodies attached to biologically active drugs by means of cleavable chemical linkers. Advances in technologies for the coupling of antibodies to cytotoxic drugs promise to deliver greater control of drug pharmacokinetic properties and to significantly improve pharmacodelivery applications, minimizing exposure of healthy tissue...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680235/transglutaminase-and-sialyltransferase-enzymatic-approaches-for-polymer-conjugation-to-proteins
#11
Katia Maso, Antonella Grigoletto, Gianfranco Pasut
Proteins hold a central role in medicine and biology, also confirmed by the several therapeutic applications based on biologic drugs. Such therapies are of great relevance thanks to high potency and safety of proteins. Nevertheless, many proteins as therapeutics might present issues like fast kidney clearance, rapid enzymatic degradation, or immunogenicity. Such defects implicate frequent administrations or administrations at high doses of the therapeutics, thus yielding or exacerbating potential side effects...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29680234/rational-design-of-liquid-formulations-of-proteins
#12
Mark C Manning, Jun Liu, Tiansheng Li, Ryan E Holcomb
Twenty years ago, a number of eminent pharmaceutical scientists collaborated on an article describing a rational approach to developing stable lyophilized protein formulations (Carpenter, Pikal, Chang, & Randolph, 1997). Since that time, no corresponding document for rational development of liquid formulations of proteins has appeared. Certainly, many of the principles underpinning rational protein formulation have been known for some time, but no overarching scheme has ever been described in the literature...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459037/preface
#13
EDITORIAL
Rossen Donev
No abstract text is available yet for this article.
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459036/targeting-intramembrane-protein-protein-interactions-novel-therapeutic-strategy-of-millions-years-old
#14
Alexander B Sigalov
Intramembrane protein-protein interactions (PPIs) are involved in transmembrane signal transduction mediated by cell surface receptors and play an important role in health and disease. Recently, receptor-specific modulatory peptides rationally designed using a general platform of transmembrane signaling, the signaling chain homooligomerization (SCHOOL) model, have been proposed to therapeutically target these interactions in a variety of serious diseases with unmet needs including cancer, sepsis, arthritis, retinopathy, and thrombosis...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459035/human-interactomics-comparative-analysis-of-different-protein-interaction-resources-and-construction-of-a-cancer-protein-drug-bipartite-network
#15
Javier De Las Rivas, Diego Alonso-López, Mónica M Arroyo
Unraveling the protein interaction wiring that occurs in human cells as a scaffold of biological processes requires the identification of all elements that constitute such molecular interaction networks. Proteome-wide experimental studies and bioinformatic comprehensive efforts have provided reliable and updated compendiums of the human protein interactome. In this work, we present a current view of available databases of human protein-protein interactions (PPIs) that allow building protein interaction networks...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459034/investigating-the-influence-of-hotspot-mutations-in-protein-protein-interaction-of-idh1-homodimer-protein-a-computational-approach
#16
D Thirumal Kumar, P Sneha, Jennifer Uppin, S Usha, C George Priya Doss
Protein-protein interaction (PPI) helps in maintaining the cellular homeostasis. In particular, the homodimeric proteins play a crucial role as cell regulators. Studying the critical functions of each PPI on the living system is very challenging. The mutations in the PPIs have given birth to various diseases including many types of cancers and it has soon become the target for drug discovery. The mutations in IDH1, an asymmetric homodimer in the cytoplasm, leads to various diseases including gliomas. In this study, we have used extensive computational approaches to identify the impact of missense mutations (R132C, R132G, R132H, R132L, R132S, and V178I) occurring in the interacting region of the IDH1 homodimer...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459033/defining-pharmacological-targets-by-analysis-of-virus-host-protein-interactions
#17
Manuel Llano, Mario A Peña-Hernandez
Viruses are obligate parasites that depend on cellular factors for replication. Pharmacological inhibition of essential viral proteins, mostly enzymes, is an effective therapeutic alternative in the absence of effective vaccines. However, this strategy commonly encounters drug resistance mechanisms that allow these pathogens to evade control. Due to the dependency on host factors for viral replication, pharmacological disruption of the host-pathogen protein-protein interactions (PPIs) is an important therapeutic alternative to block viral replication...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459032/development-of-protein-protein-interaction-inhibitors-for-the-treatment-of-infectious-diseases
#18
Andrew F Voter, James L Keck
Protein-protein interaction (PPI) inhibitors are a rapidly expanding class of therapeutics. Recent advances in our understanding of PPIs and success of early examples of PPI inhibitors demonstrate the feasibility of targeting PPIs. This review summarizes the techniques used for the discovery and optimization of a diverse set PPI inhibitors, focusing on the development of PPI inhibitors as new antibacterial and antiviral agents. We close with a summary of the advances responsible for making PPI inhibitors realistic targets for therapeutic intervention and brief outlook of the field...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459031/subcellular-targeting-of-nitric-oxide-synthases-mediated-by-their-n-terminal-motifs
#19
Carlos Costas-Insua, Javier Merino-Gracia, Clara Aicart-Ramos, Ignacio Rodríguez-Crespo
From a catalytic point of view, the three mammalian nitric oxide synthases (NOSs) function in an almost identical way. The N-terminal oxygenase domain catalyzes the conversion of l-arginine to l-citrulline plus ·NO in two sequential oxidation steps. Once l-arginine binds to the active site positioned above the heme moiety, two consecutive monooxygenation reactions take place. In the first step, l-arginine is hydroxylated to make Nω-hydroxy-l-arginine in a process that requires 1 molecule of NADPH and 1 molecule of O2 per mol of l-arginine reacted...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29459030/multifaceted-nucleolin-protein-and-its-molecular-partners-in-oncogenesis
#20
Iva Ugrinova, Maria Petrova, Mounira Chalabi-Dchar, Philippe Bouvet
Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the nucleolus. The ability of nucleolin to be involved in many cellular processes is probably related to its structural organization and its capability to form many different interactions with other proteins. Many functions of nucleolin affect cellular processes involved in oncogenesis-for instance: in ribosome biogenesis; in DNA repair, remodeling, and genome stability; in cell division and cell survival; in chemokine and growth factor signaling pathways; in angiogenesis and lymphangiogenesis; in epithelial-mesenchymal transition; and in stemness...
2018: Advances in Protein Chemistry and Structural Biology
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