journal
MENU ▼
Read by QxMD icon Read
search

Advances in Protein Chemistry and Structural Biology

journal
https://www.readbyqxmd.com/read/27567488/preface
#1
EDITORIAL
Christo Z Christov
No abstract text is available yet for this article.
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567487/understanding-the-multifaceted-role-of-human-down-syndrome-kinase-dyrk1a
#2
L J Kay, T K Smulders-Srinivasan, M Soundararajan
The dual-specificity tyrosine (Y) phosphorylation-regulated kinase DYRK1A, also known as Down syndrome (DS) kinase, is a dosage-dependent signaling kinase that was originally shown to be highly expressed in DS patients as a consequence of trisomy 21. Although this was evident some time ago, it is only in recent investigations that the molecular roles of DYRK1A in a wide range of cellular processes are becoming increasingly apparent. Since initial knowledge on DYRK1A became evident through minibrain mnb, the Drosophila homolog of DYRK1A, this review will first summarize the scientific reports on minibrain and further expand on the well-established neuronal functions of mammalian and human DYRK1A...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567486/cytochromes-p450-history-classes-catalytic-mechanism-and-industrial-application
#3
D J Cook, J D Finnigan, K Cook, G W Black, S J Charnock
Cytochromes P450, a family of heme-containing monooxygenases that catalyze a diverse range of oxidative reactions, are so-called due to their maximum absorbance at 450nm, ie, "Pigment-450nm," when bound to carbon monoxide. They have appeal both academically and commercially due to their high degree of regio- and stereoselectivity, for example, in the area of active pharmaceutical ingredient synthesis. Despite this potential, they often exhibit poor stability, low turnover numbers and typically require electron transport protein(s) for catalysis...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567485/dynamic-reorganization-and-enzymatic-remodeling-of-type-iv-collagen-at-cell-biomaterial-interface
#4
N M Coelho, V Llopis-Hernández, M Salmerón-Sánchez, G Altankov
Vascular basement membrane remodeling involves assembly and degradation of its main constituents, type IV collagen (Col IV) and laminin, which is critical during development, angiogenesis, and tissue repair. Remodeling can also occur at cell-biomaterials interface altering significantly the biocompatibility of implants. Here we describe the fate of adsorbed Col IV in contact with endothelial cells adhering on positively charged NH2 or hydrophobic CH3 substrata, both based on self-assembly monolayers (SAMs) and studied alone or mixed in different proportions...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567484/structural-plasticity-in-globins-role-of-protein-dynamics-in-defining-ligand-migration-pathways
#5
C Estarellas, L Capece, C Seira, A Bidon-Chanal, D A Estrin, F J Luque
Globins are a family of proteins characterized by the presence of the heme prosthetic group and involved in variety of biological functions in the cell. Due to their biological relevance and widespread distribution in all kingdoms of life, intense research efforts have been devoted to disclosing the relationships between structural features, protein dynamics, and function. Particular attention has been paid to the impact of differences in amino acid sequence on the topological features of docking sites and cavities and to the influence of conformational flexibility in facilitating the migration of small ligands through these cavities...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567483/recent-advances-in-computational-models-for-the-study-of-protein-peptide-interactions
#6
D Kilburg, E Gallicchio
We review computational models and software tools in current use for the study of protein-peptide interactions. Peptides and peptide derivatives are growing in interest as therapeutic agents to target protein-protein interactions. Protein-protein interactions are pervasive in biological systems and are responsible for the regulation of critical functions within the cell. Mutations or dysregulation of expression can alter the network of interactions among proteins and cause diseases such as cancer. Protein-protein binding interfaces, which are often large, shallow, and relatively feature-less, are difficult to target with small-molecule inhibitors...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27567482/molecular-modeling-and-chemoinformatics-to-advance-the-development-of-modulators-of-epigenetic-targets-a-focus-on-dna-methyltransferases
#7
F D Prieto-Martínez, A Peña-Castillo, O Méndez-Lucio, E Fernández-de Gortari, J L Medina-Franco
In light of the emerging field of Epi-informatics, ie, computational methods applied to epigenetic research, molecular docking, and dynamics, pharmacophore and activity landscape modeling and QSAR play a key role in the development of modulators of DNA methyltransferases (DNMTs), one of the major epigenetic target families. The increased chemical information available for modulators of DNMTs has opened up the avenue to explore the epigenetic relevant chemical space (ERCS). Herein, we discuss recent progress on the identification and development of inhibitors of DNMTs as potential epi-drugs and epi-probes that have been driven by molecular modeling and chemoinformatics methods...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038380/preface
#8
Rossen Donev
No abstract text is available yet for this article.
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038379/contribution-of-automated-technologies-to-ion-channel-drug-discovery
#9
REVIEW
Arturo Picones, Arlet Loza-Huerta, Pedro Segura-Chama, Cesar O Lara-Figueroa
Automated technologies are now resolving the historical relegation that ion channels have endured as targets for the new drug discovery and development global efforts. The richness and adequacy of functional assay methodologies, remarkably fluorescence-based detection of ions fluxes and patch-clamp electrophysiology recording of ionic currents, are now automated and increasingly employed for the analysis of ion channel activity. While the former is currently the most commonly applied, the latter is finally reaching the throughput capacity to be engaged in the primary screening of chemical libraries conformed by hundreds of thousands of compounds...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038378/targeting-the-channel-activity-of-viroporins
#10
REVIEW
Janet To, Wahyu Surya, Jaume Torres
Since the discovery that certain small viral membrane proteins, collectively termed as viroporins, can permeabilize host cellular membranes and also behave as ion channels, attempts have been made to link this feature to specific biological roles. In parallel, most viroporins identified so far are virulence factors, and interest has focused toward the discovery of channel inhibitors that would have a therapeutic effect, or be used as research tools to understand the biological roles of viroporin ion channel activity...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038377/the-modulation-of-potassium-channels-in-the-smooth-muscle-as-a-therapeutic-strategy-for-disorders-of-the-gastrointestinal-tract
#11
REVIEW
Diego Currò
Alterations of smooth muscle contractility contribute to the pathophysiology of important functional gastrointestinal disorders (FGIDs) such as functional dyspepsia and irritable bowel syndrome. Consequently, drugs that decrease smooth muscle contractility are effective treatments for these diseases. Smooth muscle contraction is mainly triggered by Ca(2+) influx through voltage-dependent channels located in the plasma membrane. Thus, the modulation of the membrane potential results in the regulation of Ca(2+) influx and cytosolic levels...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038376/calcium-activated-potassium-channels-potential-target-for-cardiovascular-diseases
#12
REVIEW
De-Li Dong, Yun-Long Bai, Ben-Zhi Cai
Ca(2+)-activated K(+) channels (KCa) are classified into three subtypes: big conductance (BKCa), intermediate conductance (IKCa), and small conductance (SKCa) KCa channels. The three types of KCa channels have distinct physiological or pathological functions in cardiovascular system. BKCa channels are mainly expressed in vascular smooth muscle cells (VSMCs) and inner mitochondrial membrane of cardiomyocytes, activation of BKCa channels in these locations results in vasodilation and cardioprotection against cardiac ischemia...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038375/ion-channels-in-the-eye-involvement-in-ocular-pathologies
#13
REVIEW
Jonathan P Giblin, Nuria Comes, Olaf Strauss, Xavier Gasull
The eye is the sensory organ of vision. There, the retina transforms photons into electrical signals that are sent to higher brain areas to produce visual sensations. In the light path to the retina, different types of cells and tissues are involved in maintaining the transparency of avascular structures like the cornea or lens, while others, like the retinal pigment epithelium, have a critical role in the maintenance of photoreceptor function by regenerating the visual pigment. Here, we have reviewed the roles of different ion channels expressed in ocular tissues (cornea, conjunctiva and neurons innervating the ocular surface, lens, retina, retinal pigment epithelium, and the inflow and outflow systems of the aqueous humor) that are involved in ocular disease pathophysiologies and those whose deletion or pharmacological modulation leads to specific diseases of the eye...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038374/trpm8-ion-channels-as-potential-cancer-biomarker-and-target-in-pancreatic-cancer
#14
REVIEW
Nelson S Yee
This article provides a review and discussion of the transient receptor potential melastatin-subfamily member 8 (TRPM8) ion channel as a potential biomarker and target in cancer. TRPM8 is a Ca(2+)-permeable channel that plays a major physiological role in cellular sensation and transduction of cold temperature. TRPM8 is aberrantly expressed in a variety of solid tumors including pancreatic cancer. In pancreatic adenocarcinoma cell lines and tissues, TRPM8 is overexpressed as compared to normal pancreatic ductal epithelia...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038373/polymodal-transient-receptor-potential-vanilloid-type-1-nocisensor-structure-modulators-and-therapeutic-applications
#15
REVIEW
Minghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong, Sun Choi
Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an attempt to comprehend the piquancy and pain mechanism of the archetypal vanilloids, transient receptor potential vanilloid (TRPV) 1 was discovered. TRPV1, a well-established member of the TRP family, is implicated in a range of functions including inflammation, painful stimuli sensation, and mechanotransduction. TRPV1 channels are nonselective cation receptors that are gated by a broad array of noxious ligands...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038372/p2x7-receptor-as-a-therapeutic-target
#16
REVIEW
Elena De Marchi, Elisa Orioli, Diego Dal Ben, Elena Adinolfi
P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na(+) and Ca(2+) and efflux of K(+). P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like inflammation, neuromodulation, cell death or cell proliferation and it has been associated to related pathological conditions including infectious, inflammatory, autoimmune, neurological, and musculoskeletal disorders and, in the last years, to cancer. This chapter describes structural features of P2X7, chemical properties of its agonist, antagonist, and allosteric modulators and summarizes recent advances on P2X7 receptor as therapeutic target in the aforementioned diseases...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/27038371/role-of-hemichannels-in-cns-inflammation-and-the-inflammasome-pathway
#17
REVIEW
Yuri Kim, Joanne O Davidson, Katherine C Gunn, Anthony R Phillips, Colin R Green, Alistair J Gunn
Neurodegenerative, cardiovascular, and metabolic disorders, once triggered, share a number of common features, including sustained inflammatory cell activation and vascular disruption. These shared pathways are induced independently of any genetic predisposition to the disease or the precise external stimulus. Glial cells respond to injury with an innate immune response that includes release of proinflammatory cytokines and chemokines. Vascular endothelial cells may also be affected, leading to opening of the blood-brain barrier that facilitates invasion by circulating inflammatory cells...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/26920694/preface
#18
EDITORIAL
Rossen Donev
No abstract text is available yet for this article.
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/26920693/sumoylation-and-potassium-channels-links-to-epilepsy-and-sudden-death
#19
REVIEW
Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi
Neuronal potassium ion channels play an essential role in the generation of the action potential and excitability of neurons. The dysfunction of ion channel subunits can cause channelopathies, which are associated in some cases with sudden unexplained death in epilepsy SUDEP. The physiological roles of neuronal ion channels have been largely determined, but little is known about the molecular mechanisms underlying neurological channelopathies, especially the determinants of the channels' regulation. SUMO (small ubiquitin-like modifier) proteins covalently conjugate lysine residues in a large number of target proteins and modify their functions...
2016: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/26920692/ph-sensitive-k-currents-and-properties-of-k2p-channels-in-murine-hippocampal-astrocytes
#20
REVIEW
Johannes Weller, Christian Steinhäuser, Gerald Seifert
Based on their intimate spatial association with synapses and the capillary, astrocytes are critically involved in the control of ion, transmitter, and energy homeostasis as well as regulation of the cerebral blood flow. Under pathophysiological conditions, dysfunctional astrocytes can no longer assure homeostatic control although the underlying mechanisms are poorly understood. Specifically, neurological diseases are often accompanied by acidification of the extracellular space, but the properties of astrocytes in such an acidic environment are still a matter of debate...
2016: Advances in Protein Chemistry and Structural Biology
journal
journal
42263
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"