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Journal of Oncology

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https://www.readbyqxmd.com/read/30410539/overexpression-of-irs-4-correlates-with-procaspase-3-levels-in-tumoural-tissue-of-patients-with-colorectal-cancer
#1
Patricia Sanmartín-Salinas, Luis G Guijarro
We reported that insulin receptor substrate 4 (IRS-4) levels increased in tissue from colorectal cancer (CRC) patients and promoted retinoblastoma-cyclin-dependent kinase activation. The aim of the present study was to evaluate the effect of IRS-4 on IGF-1 receptor pathway and its impact on procaspase 3 and PARP expression in RKO and HepG2 cancer cell lines. The results obtained in vitro were compared with those obtained from biopsies of patients with CRC (n = 18), tubulovillous adenomas (TA) (n = 2) and in matched adjacent normal colorectal (MANC) tissue (n = 20)...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30405714/prognostic-factors-predicting-poor-outcome-in-cancer-patients-with-febrile-neutropenia-in-the-emergency-department-usefulness-of-qsofa
#2
Seung Jae Lee, Ji Hye Kim, Seung Baik Han, Jin Hui Paik, Areum Durey
Background/Aims: Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics. This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED). Methods: The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30402100/treatment-related-adverse-effects-in-lung-cancer-patients-after-stereotactic-ablative-radiation-therapy
#3
REVIEW
Stamati Morias, Loredana G Marcu, Michala Short, Eileen Giles, Andrew Potter, Justin Shepherd, Thanh Gierlach, Eva Bezak
Introduction: Lung cancer is a disease which, despite the advancements in treatment, still has a very poor 5-year survival rate. Stereotactic ablative radiation therapy (SABR) is a highly advanced, sophisticated, and safe treatment which allows patients with early stage lung cancer to be treated effectively without invasive procedures and with excellent clinical outcomes. Avoiding surgery minimises morbidity and recovery time, bettering patients' quality of life. Furthermore, SABR allows patients unsuitable for surgery to still undergo curative treatment...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30364069/current-role-of-chemotherapy-in-nonmetastatic-nasopharyngeal-cancer
#4
REVIEW
Tapesh Bhattacharyya, Geethu Babu, Cessal Thommachan Kainickal
Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced nasopharyngeal cancer (stages III-IVB) is concurrent chemoradiation. Optimum timing and sequence of chemotherapy are not yet well-defined. The role of adjuvant and induction chemotherapy is debatable. Here we are going to highlight the role of chemotherapy in nasopharyngeal carcinoma, its benefit, and controversies regarding timing and sequences...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30356421/basal-cell-carcinoma-arises-from-interfollicular-layer-of-epidermis
#5
Sukmawati Tansil Tan, Mahmud Ghaznawie, Peter J Heenan, Ricky Dosan
Background: BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Objectives: This study aims to evaluate whether BCC arises from the follicular or interfollicular layer by using immunohistochemical staining. Methods: Twenty-three specimens of superficial and nodular BCC at its very early stage were examined...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30327670/hbv-dna-load-related-peritumoral-inflammation-and-albi-scores-predict-hbv-associated-hepatocellular-carcinoma-prognosis-after-curative-resection
#6
Rui Liao, Cheng-You Du, Jian-Ping Gong, Fang Luo
Background: Both persistent inflammatory activity and liver function damage contribute to a poor prognosis of hepatocellular carcinoma (HCC). This study aimed to develop nomograms that incorporate hepatitis virus B (HBV)-related peritumoral inflammation score (PIS) and liver function based on ALBI score to predict postoperative outcomes of HCC. Methods: The prognostic roles of HBV-related preoperative PIS and ALBI scores in HCC recurrence were examined, and then two nomograms were constructed...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30305811/additional-biomarkers-beyond-ras-that-impact-the-efficacy-of-cetuximab-plus-chemotherapy-in-mcrc-a-retrospective-biomarker-analysis
#7
Peng Zheng, Chunmin Liang, Li Ren, Dexiang Zhu, Qingyang Feng, Wenju Chang, Guodong He, Lechi Ye, Jingwen Chen, Qi Lin, Tuo Yi, Meiling Ji, Zhengchuan Niu, Mi Jian, Ye Wei, Jianmin Xu
Purpose: We aimed to identify new predictive biomarkers for cetuximab in first-line treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). Methods: The study included patients with KRAS wild-type unresectable liver-limited mCRC treated with chemotherapy with or without cetuximab. Next-generation sequencing was done for single nucleotide polymorphism according to custom panel. Potential predictive biomarkers were identified and integrated into a predictive model within a training cohort...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30298090/outcomes-following-salvage-radiation-and-systemic-therapy-for-isolated-locoregional-recurrence-of-breast-cancer-after-mastectomy-impact-of-constructed-biologic-subtype
#8
Xiaofang Wang, Jinli Ma, Xin Mei, Zhaozhi Yang, Xiaoli Yu, Xiaomao Guo, Zhen Zhang, Zhimin Shao
Purpose: This study examines factors associated with outcomes following salvage radiation and systemic therapy for breast cancer patients who developed isolated locoregional recurrence (ILRR) after mastectomy alone, while focusing on the prognostic significance of constructed biologic subtype in this setting. Methods and Materials: 269 postmastectomy patients in total treated for ILRR were included. Cumulative incidence of locoregional control (LRC), distant metastasis (DM)-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were calculated using Kaplan-Meier method...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30186324/the-utility-of-preoperative-vascular-grading-in-patients-undergoing-surgery-first-for-pancreatic-cancer-does-radiologic-arterial-or-venous-involvement-predict-pathologic-margin-status
#9
Neha Goel, Jimson W D'Souza, Karen J Ruth, Barton Milestone, Andreas Karachristos, Rajeswari Nagarathinam, Harry Cooper, John Hoffman, Sanjay Reddy
Controversy exists on accurately grading vascular involvement on preoperative imaging for pancreatic ductal adenocarcinoma. We reviewed the association between preoperative imaging and margin status in 137 patients. Radiologists graded venous involvement based on the Ishikawa classification system and arterial involvement based on preoperative imaging. For patients with both classifications recorded, we categorized vascular involvement as "None," "Arterial only," "Venous only," or "Both" and examined the association of vascular involvement and pathologic margin status...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30174692/correlation-between-psychosocial-distress-and-quality-of-life-in-patients-with-nasopharyngeal-carcinoma-following-radiotherapy
#10
Xiaolan Wang, Yue Lv, Wen Li, Chen Gan, Haijun Chen, Yingying Liu, Herta H Chao, Chiang-Shan R Li, Huaidong Cheng
The aim of this study was to investigate the relationship between psychosocial distress and quality of life (QOL) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Fifty-three patients with an initial diagnosis of NPC were enrolled in this study. The psychological Distress Thermometer (DT) and Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N) were conducted before and after radiotherapy in NPC patients. We compared the differences in psychological distress and QOL before and after radiotherapy and analyzed the correlation between psychological distress and QOL after radiotherapy...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30158978/mir-30a-a-novel-biomarker-and-potential-therapeutic-target-for-cancer
#11
REVIEW
Lin-Hong Jiang, He-da Zhang, Jin-Hai Tang
MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18-25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3'untranslated region (3'UTR) of target mRNAs. MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes. Several studies have reported that miR-30a, situated on chromosome 6q.13, is produced by an intronic transcriptional unit. Moreover, miR-30a has demonstrated its role in biological processes, including inhibiting proliferation and metastasis in many tumors, autophagy in chronic myelogenous leukemia, and regulating TGF-b1-induced epithelial-mesenchymal transition...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30158977/a-machine-learning-approach-for-the-association-of-ki-67-scoring-with-prognostic-factors
#12
E Dirican, E Kiliç
ki-67 score is a solid tumor proliferation marker being associated with the prognosis of breast carcinoma and its response to neoadjuvant chemotherapy. In the present study, we aimed to investigate the way of clustering of prognostic factors by ki-67 score using a machine learning approach and multiple correspondence analysis. In this study, 223 patients with breast carcinoma were analyzed using the random forest method for classification of prognostic factors according to ki-67 groups (<14% and >14%)...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30154846/the-association-of-simultaneous-increase-in-interleukin-6-c-reactive-protein-and-matrix-metalloproteinase-9-serum-levels-with-increasing-stages-of-colorectal-cancer
#13
Ismar Rasic, Velma Rebic, Azra Rasic, Goran Aksamija, Svjetlana Radovic
Background: Tumor development and growth are driven in many cases by inflammatory cells, which can produce cytokines and other factors that can stimulate the development of the malignant process. The aim of this study was to evaluate interleukin-6 (IL-6), C-reactive protein (CRP), matrix metalloproteinase-9 (MMP-9), serum levels in patients with colorectal cancer (CRC), and their association with the stage of CRC. Methods: IL-6, MMP-9, and CRP serum levels were measured in 75 patients with CRC just before surgical treatment, as well as in 20 healthy individuals as controls...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30112001/clinical-and-molecular-characteristics-associated-with-survival-in-advanced-melanoma-treated-with-checkpoint-inhibitors
#14
REVIEW
Sunil Badami, Sunil Upadhaya, Ravi Kanth Velagapudi, Pushyami Mikkilineni, Ranju Kunwor, Samer Al Hadidi, Ghassan Bachuwa
Background: We performed meta-analysis to gather more evidence regarding clinical-molecular subgroups associated with better overall survival (OS) in advanced melanoma treated with checkpoint inhibitors. Materials and Methods: We performed a systematic search of PubMed, Scopus, Cochrane Library, and clinical trial.gov. Randomized clinical trials that compared a checkpoint inhibitor (nivolumab or pembrolizumab) with investigator choice chemotherapy or ipilimumab were included in our study...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30112000/inhibition-of-mdm2-via-nutlin-3a-a-potential-therapeutic-approach-for-pleural-mesotheliomas-with-mdm2-induced-inactivation-of-wild-type-p53
#15
Robert F H Walter, Robert Werner, Michael Wessolly, Elena Mairinger, Sabrina Borchert, Jan Schmeller, Jens Kollmeier, Thomas Mairinger, Thomas Hager, Agnes Bankfalvi, Daniel C Christoph, Wilfried E E Eberhardt, Till Plönes, Clemens Aigner, Kurt W Schmid, Jeremias Wohlschlaeger, Fabian D Mairinger
Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that eventually results in a loss of TP53-induced apoptosis and senescence. It is well known from other tumor entities that restoration of TP53 activity, e.g., by MDM2 inhibition, results in an instant TP53-induced stress and/or DNA damage response of cancer cells...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30111999/s100a4-may-be-a-good-prognostic-marker-and-a-therapeutic-target-for-colon-cancer
#16
Sabahattin Destek, Vahit Onur Gul
Background: Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Methods: Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30057606/research-priorities-and-resource-allocation-in-the-investigation-of-new-drugs-for-cancer-in-least-developed-countries
#17
REVIEW
Ricardo Eccard da Silva, Angélica Amorim Amato, Débora Dornelas Belchior Costa Andrade, Alessandra Vanessa Leite E Silva, Marta Rodrigues de Carvalho, Maria Rita Carvalho Garbi Novaes
Cancer incidence has increased significantly in low- and middle-income countries. The priorities of international health research are not always aligned with the global burden of cancer. This study aims to analyze global tendencies in clinical trials in oncology and discuss research priorities and resource allocation in the investigation of new drugs for cancers that significantly affect the least developed countries. This was a retrospective and analytical study that included data collected from the World Health Organization's International Clinical Trials Registry Platform (ICTRP) in 2014...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30057605/the-role-of-the-vagus-nerve-in-cancer-prognosis-a-systematic-and-a-comprehensive-review
#18
REVIEW
Marijke De Couck, Ralf Caers, David Spiegel, Yori Gidron
This article reviews the role of the vagus nerve in tumor modulation and cancer prognosis. We present a systematic review of 12 epidemiological studies examining the relationship between heart rate variability, the main vagus nerve index, and prognosis in cancer patients (survival and tumor markers). These studies show that initially high vagal nerve activity predicts better cancer prognosis, and, in some studies, independent of confounders such as cancer stage and treatments. Since the design of the epidemiological studies is correlational, any causal relationship between heart rate variability and cancer prognosis cannot be inferred...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30046308/survival-outcomes-and-factors-associated-with-revision-surgery-for-metastatic-disease-of-the-spine
#19
Vignesh K Alamanda, Myra M Robinson, Jeffrey S Kneisl, Leo R Spector, Joshua C Patt
Study Design: Retrospective review of a prospective database. Objective: Certain subset of patients undergoing surgical treatment for spinal metastasis will require a revision surgery in their disease course; however, factors predictive of revision surgery and survival outcomes are largely unknown. The goal of this study is to report on survival outcomes as well as factors predictive of revision surgery in this unique patient population. Methods: A total of 55 patients who met the inclusion criteria were included from January 2010 to December 2015...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30018640/advancing-parental-age-and-risk-of-solid-tumors-in-children-a-case-control-study-in-peru
#20
Ligia Rios, Liliana Vásquez, Mónica Oscanoa, Iván Maza, Jenny Gerónimo
Background: The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors. Methods: We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Odd ratio was used to compare categories of advancing maternal and paternal age with and without adjusting for possible confounding factors were calculated...
2018: Journal of Oncology
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