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Journal of Oncology

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https://www.readbyqxmd.com/read/29977293/-tff1-and-tff3-mrnas-are-higher-in-blood-from-breast-cancer-patients-with-metastatic-disease-than-those-without
#1
Marwa H Elnagdy, Omar Farouk, Amal K Seleem, Hoda A Nada
Introduction: Breast cancer metastasis occurs when tumor cells dissociate from the primary tumor and migrate to distant organs through the peripheral bloodstream or lymphatic drainage. Circulating tumor cells (CTCs) originate from primary sites or metastases and circulate in the patients' bloodstream. Molecular assays for the detection and molecular characterization of CTCs can serve as a liquid biopsy and can represent an alternative to invasive biopsies as a source of tumor tissue in the metastatic patients...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29971105/epimutation-and-cancer-carcinogenesis-viewed-as-error-prone-inheritance-of-epigenetic-information
#2
REVIEW
Patrick A Riley
The epimutation concept, that is, malignancy is a result of deranged patterns of gene expression due to defective epigenetic control, proposes that in the majority of adult cancers the primary (initiating) lesion adversely affects the mechanism of vertical transmission of the epigenetic pattern existing in the stem cells of differentiated tissue. Such an error-prone mechanism will result in deviant gene expression capable of accumulation at each mitosis of the affected stem cell clone. It is argued that a proportion of these proliferation products will express combinations of genes which endow them with malignant properties, such as the ability to transgress tissue boundaries and migrate to distant locations...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29971104/complex-karyotype-in-hematological-diseases-a-6-year-single-centre-study-from-pakistan
#3
Samra Waheed, Jawad Hassan, Maliha Naz, Sidra Maqsood, Madiha Abid, Saira Shan, Muhammad Nadeem, Tahir S Shamsi
Background: Most of the hematological disorders are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. Though rarer, complex karyotype has been associated with worst prognosis. Materials and Methods: A total of 1185 bone marrow or peripheral blood cytogenetics samples were taken with different hematological diseases...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29861726/multifactorial-analysis-of-mortality-in-screening-detected-lung-cancer
#4
Subba R Digumarthy, Ruben De Man, Rodrigo Canellas, Alexi Otrakji, Ge Wang, Mannudeep K Kalra
We hypothesized that severity of coronary artery calcification (CAC), emphysema, muscle mass, and fat attenuation can help predict mortality in patients with lung cancer participating in the National Lung Screening Trial (NLST). Following regulatory approval from the Cancer Data Access System (CDAS), all patients diagnosed with lung cancer at the time of the screening study were identified. These subjects were classified into two groups: survivors and nonsurvivors at the conclusion of the NLST trial. These groups were matched based on their age, gender, body mass index (BMI), smoking history, lung cancer stage, and survival time...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29853890/the-plasticity-of-cd4-cd25-foxp3-cd127-low-t-cells-in-patients-with-metastatic-renal-cell-carcinoma-in-the-course-of-interferon-alpha-immunotherapy
#5
Maria S Sayapina, Svetlana N Bykovskaia
Aims: To examine changes in subpopulation of CD4+ CD25+ Foxp3+ CD127low T lymphocytes (Treg) and their association with the efficiency of the IFN- α therapy. Materials and Methods: Pts with mRCC who had undergone nephrectomy were treated with IFN- α at a dose of 6 × 106  U/day three times a week ( n = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN- α therapy and 22 normal volunteers...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29853889/capecitabine-and-temozolomide-in-neuroendocrine-tumor-of-unknown-primary
#6
Aman Chauhan, Zainab Farooqui, Le Aundra Murray, Heidi L Weiss, Zin War Myint, Arun Kumar A Raajasekar, B Mark Evers, Susanne Arnold, Lowell Anthony
Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise. The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients. About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined. Combination of capecitabine and temozolomide (CAPTEM) is one of the systemic treatments used in gastroenteropancreatic NETs. We explored clinical activity of CAPTEM in NET of unknown primary...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29849631/the-caribbean-community-clinical-oncology-workforce-analyzing-where-we-are-today-and-projecting-for-tomorrow
#7
Kellie Alleyne-Mike
Purpose: To analyze the current physician clinical oncological workforce within the CARICOM full member states with an aim to make recommendations for building capacity. Methods: A questionnaire was prepared and emailed to professionals working in oncology in 14 CARICOM full member countries. It was designed to identify the number of specialists providing hematology, medical oncology, and radiotherapy services. Results: Ten countries (71.4%) supplied information...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29849630/hereditary-nonpolyposis-colorectal-cancer-and-cancer-syndromes-recent-basic-and-clinical-discoveries
#8
REVIEW
Erbao Chen, Xiaojing Xu, Tianshu Liu
Approximately one-third of individuals diagnosed with colorectal cancer have a family history of cancer, suggesting that CRCs may result from a heritable component. Despite the availability of current gene-identification techniques, only 5% of all CRCs emerge from well-identifiable inherited causes for predisposition, including polyposis and nonpolyposis syndromes. Hereditary nonpolyposis colorectal cancer represents a large proportion of cases, and robustly affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies and extracolonic malignancies...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29849629/multiple-myeloma-of-the-central-nervous-system-13-cases-and-review-of-the-literature
#9
REVIEW
Gergely Varga, Gábor Mikala, László Gopcsa, Zoltán Csukly, Sarolta Kollai, György Balázs, Tímár Botond, Nikolett Wohner, Laura Horváth, Gergely Szombath, Péter Farkas, Tamás Masszi
Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy. We present 13 cases diagnosed at two centers in Budapest and review the current literature. The majority of our cases presented with high-risk features initially; two had plasma cell leukemia. Repeated genetic tests showed clonal evolution in 3 cases. Treatments varied according to the era, and efficacy was poor as generally reported in the literature. Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29849628/health-related-quality-of-life-of-cancer-patients-in-ethiopia
#10
Tadesse Melaku Abegaz, Asnakew Achaw Ayele, Begashaw Melaku Gebresillassie
Background: Neoplasm, AKA cancer (Ca), is associated with major morbidity and mortality. Aim: Measurement of health related quality of life (HRQoL) of Ca patients is uncommon in Ethiopia. The present study determined the HRQoL and its determinants among people living with Ca in north Ethiopia. Methods: A prospective hospital based study was conducted from 1 January 2017 to 30 August 2017 on Ca patients attending cancer treatment center of University of Gondar Teaching Hospital...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29785183/evaluation-of-reirradiation-in-locally-advanced-head-and-neck-cancers-toxicity-and-early-clinical-outcomes
#11
Amit Bahl, Arun Singh Oinam, Arun Elangovan, Satinder Kaur, Gaurav Trivedi, Roshan Verma, Sudhir Bhandari, Sushmita Ghoshal, Naresh Kumar Panda
Objectives: Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers. Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease. The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation. Methods: Twenty patients of head and neck cancers with recurrences or second cancers were evaluated. Reirradiation was done using simultaneous integrated boost volumetric modulated arc therapy (SIB VMAT), intensity modulated radiotherapy (IMRT), or conventional radiotherapy using 6MV photons...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29755525/quality-of-life-depression-and-anxiety-in-patients-with-uveal-melanoma-a-review
#12
REVIEW
Mario Miniati, Maria Grazia Fabrini, Federica Genovesi Ebert, Maricia Mancino, Alessandra Maglio, Gabriele Massimetti, Enrico Massimetti, Donatella Marazziti
The aim is to summarize current knowledge on both QoL and depressive/anxious symptoms in patients with UM, including studies on the effect on QoL and psychological status of genetic testing related to the risk of metastatic disease. A review from the last 25 years by using the databases "PsycInfo," "Medline," and "Science Direct" was performed. As a total result, eighteen papers were retrieved. Eight studies (44.4%) used a prospective design methodology: two were retrospective observations (11...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29707001/experience-and-expectations-of-ovarian-cancer-patients-in-australia
#13
Catherine M Holliday, Maria Morte, Josephine M Byrne, Anne T Holliday
Some of the most significant advances in ovarian cancer treatment have been those that result in improvements in progression-free survival (PFS); however there is little research to understand the value that patients place on accessing therapies that result in PFS as a clinical outcome related to survivorship. This study therefore aimed to understand the experience and expectations of women with ovarian cancer in Australia in relation to quality of life (QoL) and treatment options. An online survey collected demographic information and 13 investigator-derived structured interview questions were developed to understand the experience of women with ovarian cancer, their understanding of terminology associated with their condition, and expectations of future treatment...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29686705/intraoral-potentially-malignant-disorders-in-a-brazilian-oral-pathology-service-epidemiological-clinical-and-histopathological-findings
#14
Fernanda Weber Mello, Gilberto Melo, Maria Inês Meurer, Elena Riet Correa Rivero
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Histological diagnoses were collected from histopathological records. Among 208 IOPMD cases, 84.13% involved LKP; 11.1%, ELKP; and 4...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29666643/rna-seq-reveals-the-overexpression-of-igsf9-in-endometrial-cancer
#15
Zonggao Shi, Chunyan Li, Laura Tarwater, Jun Li, Yang Li, William Kaliney, Darshan S Chandrashekar, M Sharon Stack
We performed RNA-seq on an Illumina platform for 7 patients with endometrioid endometrial carcinoma for which both tumor tissue and adjacent noncancer tissue were available. A total of 66 genes were differentially expressed with significance level at adjusted p value < 0.01. Using the gene functional classification tool in the NIH DAVID bioinformatics resource, 5 genes were found to be the only enriched group out of that list of genes. The gene IGSF9 was chosen for further characterization with immunohistochemical staining of a larger cohort of human endometrioid carcinoma tissues...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29552034/the-efficacy-of-conventionally-fractionated-radiation-in-the-management-of-osseous-metastases-from-metastatic-renal-cell-carcinoma
#16
Rohit Gunan Ganju, Mindi TenNapel, Nicholas Mahan, Amir Zahra, Xinglei Shen
Background: There is little data regarding the effectiveness of palliative radiation with conventional fractionation for metastatic renal cell carcinoma (RCC), which has been described as radioresistant. We conducted a retrospective analysis of patients with metastatic bony disease from RCC treated with radiation therapy at our institution. Methods: Forty patients with histologically confirmed RCC with a total of 53 treatment courses were included. Pain response after radiotherapy was recorded and freedom from progression was generated using posttreatment radiographs...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/29333160/corrigendum-to-the-current-practice-of-screening-prevention-and-treatment-of-androgen-deprivation-therapy-induced-osteoporosis-in-patients-with-prostate-cancer
#17
Humaid O Al-Shamsi, Arthur N Lau, Kartika Malik, Abdulaziz Alamri, George Ioannidis, Tom Corbett, J D Adachi, Alexandra Papaioannou
[This corrects the article DOI: 10.1155/2012/958596.].
2017: Journal of Oncology
https://www.readbyqxmd.com/read/29230244/tumor-lysis-syndrome-in-patients-with-hematological-malignancies
#18
REVIEW
Yohannes Belay, Ketsela Yirdaw, Bamlaku Enawgaw
Tumor lysis syndrome is a metabolic complication that may follow the initiation of cancer therapy. It commonly occurs in hematological malignant patients particularly non-Hodgkin's lymphoma and acute leukemia due to chemotherapy or spontaneously. It is characterized by a biochemical abnormality such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia and its clinical outcome is directly related to these biochemical abnormalities. Prevention and treatment of tumor lysis syndrome depend on immediate recognition of patients at risk...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/29225623/ki-67-expression-by-immunohistochemistry-and-quantitative-real-time-polymerase-chain-reaction-as-predictor-of-clinical-response-to-neoadjuvant-chemotherapy-in-locally-advanced-breast-cancer
#19
Prihantono Prihantono, Mochammad Hatta, Christian Binekada, Daniel Sampepajung, Haryasena Haryasena, Berti Nelwan, Andi Asadul Islam, Andi Nilawati Usman
Background: Chemotherapy has become a standard of treatment in managing breast cancer. To achieve proper treatment for the right patients, the predictive marker is needed. Ki-67 is a biomarker of proliferation for solid tumor. Studies mentioned association of Ki-67 expression with chemotherapy response. The study aims are to evaluate whether Ki-67 expression detected by immunohistochemistry (IHC) and quantitative real-time polymerase chain reaction (qRT-PCR) may predict clinical response to neoadjuvant chemotherapy in breast cancer...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/29081801/level-of-concordance-of-pre-intra-and-postoperative-staging-in-cervical-cancers-treya-study
#20
M Toure, A T Bambara, K K Y Kouassi, E N Seka, J M Dia, I Yao, O Kimso, I Adoubi
Concomitant radiochemotherapy is the therapeutic standard for locally advanced (Ib2 to IVa stage FIGO) cervical cancer. In the absence of a radiotherapy in many of our Sub-Saharan African countries, surgical resection is the only therapeutic method available in hopes of achieving a definite cure. However, criteria for curative surgery are not always met due to preoperative understaging of most of our patients. In addition to socioeconomic factors, the causes for understaging are numerous. These include the lack of personnel or underqualified personnel and the absence of complete workup to assess the resectability of the tumor, but above all the lack of decision-making through multidisciplinary consultation meetings...
2017: Journal of Oncology
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