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Journal of Oncology

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https://www.readbyqxmd.com/read/27882053/hypoxia-inducible-factor-1%C3%AE-expression-in-indonesian-laryngeal-squamous-cell-carcinoma-patients
#1
Agus Surono, Priyanto Priyanto, Sagung Rai Indrasari
Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody. The association between HIF-1α expression and clinical stage was analyzed using the chi square test...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27746816/the-role-of-pulmonary-veins-in-cancer-progression-from-a-computed-tomography-viewpoint
#2
Chuang-Chi Liaw, Hung Chang, Tzu-Yao Liao, Ming-Sheng Wen, Chih-Teng Yu, Yu-Hsiang Juan
Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in the lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence in the lungs...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27635139/study-of-the-effects-of-betaine-and-or-c-phycocyanin-on-the-growth-of-lung-cancer-a549-cells-in-vitro-and-in-vivo
#3
Rea Bingula, Carmen Dupuis, Chantal Pichon, Jean-Yves Berthon, Marc Filaire, Lucie Pigeon, Edith Filaire
We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27478441/precancerous-cervix-in-human-immunodeficiency-virus-infected-women-thirty-years-old-and-above-in-northern-uganda
#4
Jonathan Izudi, Norbert Adrawa, Dinah Amongin
Background. Little is known about precancerous cervical lesion (PCCL), the precursor of cervical cancer among Human Immunodeficiency (HIV) infected women in a postconflict setting of Northern Uganda. Objective. To establish factors associated with PCCL among HIV infected women above thirty years of age in a postconflict setting of Northern Uganda. Method. This retrospective cohort study used electronic data from 995 HIV-positive women that attended cervical cancer screening during June 2014 and December 2015...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27446211/clinical-performance-and-management-outcomes-with-the-decisiondx-um-gene-expression-profile-test-in-a-prospective-multicenter-study
#5
Kristen Meldi Plasseraud, Robert W Cook, Tony Tsai, Yevgeniy Shildkrot, Brooke Middlebrook, Derek Maetzold, Jeff Wilkinson, John Stone, Clare Johnson, Kristen Oelschlager, Thomas M Aaberg
Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27429617/low-level-of-microsatellite-instability-correlates-with-poor-clinical-prognosis-in-stage-ii-colorectal-cancer-patients
#6
Ehsan Nazemalhosseini Mojarad, Seyed Mohammad Hossein Kashfi, Hanieh Mirtalebi, Mohammad Yaghoob Taleghani, Pedram Azimzadeh, Sanaz Savabkar, Mohammad Amin Pourhoseingholi, Hasan Jalaeikhoo, Hamid Asadzadeh Aghdaei, Peter J K Kuppen, Mohammad Reza Zali
The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC) requires more investigation. We assessed the role of MSI status in survival of individuals diagnosed with primary colorectal cancer. In this retrospective cross-sectional study the MSI status was determined in 158 formalin-fixed paraffin-embedded tumors and their matched normal tissues from patients who underwent curative surgery. Cox proportional hazard modeling was performed to assess the clinical prognostic significance...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27382369/changes-in-pathological-complete-response-rates-after-neoadjuvant-chemotherapy-for-breast-carcinoma-over-five-years
#7
Daniel C McFarland, Jessica Naikan, Mariya Rozenblit, John Mandeli, Ira Bleiweiss, Amy Tiersten
Historically, neoadjuvant chemotherapy (NACT) was extrapolated from adjuvant regimens. Dual HER2 blockade and the introduction of carboplatin for triple negative breast cancers (TNBC) emerged by December 2013 and have improved pathological complete response (pCR) rates. The objective of this study was to assess the pCR rates before and after the introduction of these new neoadjuvant regimens. Materials and Methods. Stage I-III breast cancer patients who received NACT were analyzed for rates of pCR by clinical characteristics (i...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27340404/clinicopathological-profile-of-pure-neuroendocrine-neoplasms-of-the-esophagus-a-south-indian-center-experience
#8
Govind Babu Kanakasetty, Loknatha Dasappa, Kuntegowdanahalli Chinnagiriyappa Lakshmaiah, Mangesh Kamath, Linu Abraham Jacob, Suresh Babu Mallekavu, Lakkavalli Krishnappa Rajeev, Rudresha Antapura Haleshappa, Lokesh Kadabur Nagendrappa, Smitha Carol Saldanha, Rekha V Kumar
Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014. Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27313614/frequency-of-bcr-abl-transcript-types-in-syrian-cml-patients
#9
Sulaf Farhat-Maghribi, Wafa Habbal, Fawza Monem
Background. In Syria, CML patients are started on tyrosine kinase inhibitors (TKIs) and monitored until complete molecular response is achieved. BCR-ABL mRNA transcript type is not routinely identified, contrary to the recommendations. In this study we aimed to identify the frequency of different BCR-ABL transcripts in Syrian CML patients and highlight their significance on monitoring and treatment protocols. Methods. CML patients positive for BCR-ABL transcripts by quantitative RT-PCR were enrolled. BCR-ABL transcript types were investigated using a home-made PCR method that was adapted from published protocols and optimized...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27242900/curcumin-and-resveratrol-as-promising-natural-remedies-with-nanomedicine-approach-for-the-effective-treatment-of-triple-negative-breast-cancer
#10
REVIEW
Amol Shindikar, Akshita Singh, Malcolm Nobre, Saurabh Kirolikar
Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical entities for effective treatment of most breast cancer phenotypes, resulting in increased patient survivability. Unfortunately, these strategies have been largely ineffective in the treatment of triple negative breast cancer (TNBC)...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27239196/excisional-treatment-of-cervical-dysplasia-in-australia-2004-2013-a-population-based-study
#11
Gregory Robertson, Stephen J Robson
Background. Excisional treatment of preinvasive cervical dysplasia has been associated with adverse pregnancy outcomes. We aimed to examine trends in the rate of excisional treatment in reproductive age women in the era of HPV vaccination. Methods. National data for Australia regarding histological diagnoses of cervical dysplasia and excisional treatment for the period from 2004 to 2013 inclusive were obtained from two datasets and used to calculate age-stratified incidence rates of excisional treatment and of excisional treatments per diagnosis of dysplasia...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27066075/moving-beyond-karnofsky-and-ecog-performance-status-assessments-with-new-technologies
#12
REVIEW
Ciara M Kelly, Armin Shahrokni
Progress in cancer research is coupled with increased treatment complexity reliant upon accurate patient selection. Oncologists rely upon measurement instruments of functional performance such as the Karnofsky or Eastern Cooperative Oncology Group Performance Status scales that were developed over fifty years ago to determine a patient's suitability for systemic treatment. These standard assessment tools have been shown to correlate with response to chemotherapy, chemotherapy tolerability, survival, and quality of life of cancer patients...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27042179/correlation-of-beta-2-adrenergic-receptor-expression-in-tumor-free-surgical-margin-and-at-the-invasive-front-of-oral-squamous-cell-carcinoma
#13
Denise Tostes Oliveira, Diego Mauricio Bravo-Calderón, Gustavo Amaral Lauand, Agnes Assao, José-Manuel Suárez-Peñaranda, Mario Pérez-Sayáns, Abel García-García, Aparecido Nilceu Marana, Suely Nonogaki, José Roberto Pereira Lauris, Luiz Paulo Kowalski
Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer's exact test...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27034667/enchondroma-versus-chondrosarcoma-in-long-bones-of-appendicular-skeleton-clinical-and-radiological-criteria-a-follow-up
#14
Eugenio M Ferrer-Santacreu, Eduardo J Ortiz-Cruz, Mariana Díaz-Almirón, Jose Juan Pozo Kreilinger
As of today two types of cartilage tumors remain a challenge even for the orthopedic oncologist: enchondroma (E), a benign tumor, and chondrosarcoma (LGC), a malignant and low aggressiveness tumor. A prospective study of 133 patients with a cartilaginous tumor of low aggressiveness in the long bones of the appendicular skeleton was done to prove this difficult differential diagnosis. Parameters including medical history and radiological and nuclear imaging were collected and compared to the result of the biopsy...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27019657/timp-1-as-well-as-microvessel-invasion-and-high-nuclear-grade-is-a-significant-determinant-factor-for-extension-of-tumor-diameter-in-localized-rcc
#15
Nozomu Kawata, Kenya Yamaguchi, Tomohiro Igarashi, Satoru Takahashi
Objectives. To clarify what kind of pathological factor is necessary for the extension of tumor diameter in localized RCC, we studied localized RCC patients. Methods. We retrospectively reviewed medical records of 237 RCC patients in our institute who underwent nephrectomy. We performed immune histological analysis of MMP-2, MMP-9, TIMP-1, TIMP-2, and MT-MMP-1 for all samples. Results. Among the clinicopathological factors, multivariate analysis revealed nuclear grade; TIMP-2 and MT-MMP-1 were independent prognostic factors of localized RCC (risk ratio 1...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/26981122/the-oncogenic-functions-of-nicotinic-acetylcholine-receptors
#16
REVIEW
Yue Zhao
Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells. Recent findings suggest that nAChRs not only mediate nicotine addiction in the brain but also contribute to the development and progression of cancers directly induced by nicotine and its derived carcinogenic nitrosamines whereas deregulation of the nAChRs is observed in many cancers, and genome-wide association studies (GWAS) indicate that SNPs nAChRs associate with risks of lung cancers and nicotine addiction...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/26977148/recombinant-human-thyroid-stimulating-hormone-versus-thyroid-hormone-withdrawal-for-radioactive-iodine-treatment-of-differentiated-thyroid-cancer-with-nodal-metastatic-disease
#17
Robert M Wolfson, Irina Rachinsky, Deric Morrison, Al Driedger, Tamara Spaic, Stan H M Van Uum
Introduction. Recombinant human thyroid stimulating hormone (rhTSH) is approved for preparation of thyroid remnant ablation with radioactive iodine (RAI) in low risk patients with well differentiated thyroid cancer (DTC). We studied the safety and efficacy of rhTSH preparation for RAI treatment of thyroid cancer patients with nodal metastatic disease. Methods. A retrospective analysis was performed on 108 patients with histopathologically confirmed nodal metastatic DTC, treated with initial RAI between January 1, 2000, and December 31, 2007...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/26949394/does-the-degree-of-hepatocellular-carcinoma-tumor-necrosis-following-transarterial-chemoembolization-impact-patient-survival
#18
Nathan Haywood, Kyle Gennaro, John Obert, Paul F Sauer, David T Redden, Jessica Zarzour, J Kevin Smith, David Bolus, Souheil Saddekni, Ahmed Kamel Abdel Aal, Stephen Gray, Jared White, Devin E Eckhoff, Derek A DuBay
Purpose. The association between transarterial chemoembolization- (TACE-) induced HCC tumor necrosis measured by the modified Response Evaluation Criteria In Solid Tumors (mRECIST) and patient survival is poorly defined. We hypothesize that survival will be superior in HCC patients with increased TACE-induced tumor necrosis. Materials and Methods. TACE interventions were retrospectively reviewed. Tumor response was quantified via dichotomized (responders and nonresponders) and the four defined mRECIST categories...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/26823665/small-cell-carcinoma-of-the-gallbladder-case-report-and-comprehensive-analysis-of-published-cases
#19
REVIEW
Carolyn Carrera, Paul Kunk, Osama Rahma
Background. Gallbladder small cell carcinoma is a rare and highly aggressive malignancy with no established standard of care treatment. We described here a case report of small cell gallbladder cancer and we then performed a comprehensive review of 72 case reports of this disease. Methods. Published case reports of small cell carcinoma of the gallbladder between 1983 and 2014 were reviewed. Treatment modalities and survival were analyzed for metastatic and localized disease. Results. Median overall survival for all patients was 13 months...
2015: Journal of Oncology
https://www.readbyqxmd.com/read/26713092/adjuvant-iodine-131-lipiodol-after-resection-of-hepatocellular-carcinoma
#20
Ruelan V Furtado, Leo Ha, Stephen Clarke, Charbel Sandroussi
Background. Survival after liver resection for HCC is compromised by a high rate of intrahepatic recurrence. Adjuvant treatment with a single, postoperative dose of intra-arterial I(131) lipiodol has shown promise, as a means of prolonging disease-free survival (DFS). Methodology. DFS and overall survival (OS) after a single dose of postoperative I(131) lipiodol were compared to liver resection alone, for treatment of hepatocellular carcinoma (HCC). Data were collected retrospectively for patients who had a curative resection for HCC between December 1993 and September 2011...
2015: Journal of Oncology
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