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Journal of Oncology

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https://www.readbyqxmd.com/read/28458690/colorectal-cancer-in-jordan-survival-rate-and-its-related-factors
#1
Ghazi Faisal Sharkas, Kamal H Arqoub, Yousef S Khader, Mohammad R Tarawneh, Omar F Nimri, Marwan J Al-Zaghal, Hadil S Subih
Objectives. To estimate the survival rate of colorectal cancer (CRC) and determine its predictors among Jordanian patients who were diagnosed in the period of 2005-2010. Methods. This study was based on Jordan cancer registry. All CRC cases that were registered in cancer registry during 2005-2010 were analyzed using the survival analysis. The last date for follow-up was 1st Oct 2016. Results. A total of 3005 patients with CRC were registered during 2005-2010. The overall 5-year and 10-year survival rates for patients with CRC were 58...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28421114/status-of-epstein-barr-virus-coinfection-with-helicobacter-pylori-in-gastric-cancer
#2
REVIEW
Shyam Singh, Hem Chandra Jha
Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28392802/capturing-genomic-evolution-of-lung-cancers-through-liquid-biopsy-for-circulating-tumor-dna
#3
REVIEW
Michael Offin, Jacob J Chabon, Pedram Razavi, James M Isbell, Charles M Rudin, Maximilian Diehn, Bob T Li
Genetic sequencing of malignancies has become increasingly important to uncover therapeutic targets and capture the tumor's dynamic changes to drug sensitivity and resistance through genomic evolution. In lung cancers, the current standard of tissue biopsy at the time of diagnosis and progression is not always feasible or practical and may underestimate intratumoral heterogeneity. Technological advances in genetic sequencing have enabled the use of circulating tumor DNA (ctDNA) analysis to obtain information on both targetable mutations and capturing real-time Darwinian evolution of tumor clones and drug resistance mechanisms under selective therapeutic pressure...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28286519/erbb-proteins-as-molecular-target-of-dietary-phytochemicals-in-malignant-diseases
#4
REVIEW
Alexandru Filippi, Oana-Alina Ciolac, Constanța Ganea, Maria-Magdalena Mocanu
ErbB proteins overexpression, in both normal and mutated forms, is associated with invasive forms of cancer prone to metastasis and with stronger antiapoptotic mechanisms and therefore more challenging to treat. Downstream effectors of ErbB receptors mediating these phenotypic traits include MAPK, STAT, and PI3K/AKT/mTOR pathways. Various phytochemical compounds were studied for their large number of biological effects including anticancer activity. Among these compounds, epigallocatechin-3-gallate (EGCG), the main catechin from green tea leaves, and curcumin, component of the curry powder, constituted the object of numerous studies...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28194179/the-prognostic-role-of-nedd9-and-p38-protein-expression-levels-in-urinary-bladder-transitional-cell-carcinoma
#5
Ola A Harb, Rasha Haggag, Maged M Ali, Shereen El Shorbagy, Abeer M Abdelbary, Lobna A Abdelaziz, Reham A Salim, Khaled M Abdel Wahab
Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling. Methods. To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC. Results. The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (p < 0...
2017: Journal of Oncology
https://www.readbyqxmd.com/read/28096814/hyaluromycin-a-novel-hyaluronidase-inhibitor-attenuates-pancreatic-cancer-cell-migration-and-proliferation
#6
Shiro Kohi, Norihiro Sato, Atsuhiro Koga, Keiji Hirata, Enjuro Harunari, Yasuhiro Igarashi
Pancreatic ductal adenocarcinoma (PDAC) is characterized by accelerated production and degradation of hyaluronan (HA), a major component of extracellular matrix involved in the malignant phenotype of cancer. In particular, increased hyaluronidase (HYAL) activity plays a critical role in cancer progression, at least in part, by producing low-molecular-weight- (LMW-) HA or small fragments of HA, suggesting HYAL as a target for cancer treatment. Hyaluromycin, a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived Streptomyces hyaluromycini as a HYAL inhibitor...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27882053/hypoxia-inducible-factor-1%C3%AE-expression-in-indonesian-laryngeal-squamous-cell-carcinoma-patients
#7
Agus Surono, Priyanto Priyanto, Sagung Rai Indrasari
Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody. The association between HIF-1α expression and clinical stage was analyzed using the chi square test...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27746816/the-role-of-pulmonary-veins-in-cancer-progression-from-a-computed-tomography-viewpoint
#8
Chuang-Chi Liaw, Hung Chang, Tzu-Yao Liao, Ming-Sheng Wen, Chih-Teng Yu, Yu-Hsiang Juan
Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in the lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence in the lungs...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27635139/study-of-the-effects-of-betaine-and-or-c-phycocyanin-on-the-growth-of-lung-cancer-a549-cells-in-vitro-and-in-vivo
#9
Rea Bingula, Carmen Dupuis, Chantal Pichon, Jean-Yves Berthon, Marc Filaire, Lucie Pigeon, Edith Filaire
We investigated the effects of betaine, C-phycocyanin (C-PC), and their combined use on the growth of A549 lung cancer both in vitro and in vivo. When cells were coincubated with betaine and C-PC, an up to 60% decrease in viability was observed which is significant compared to betaine (50%) or C-PC treatment alone (no decrease). Combined treatment reduced the stimulation of NF-κB expression by TNF-α and increased the amount of the proapoptotic p38 MAPK. Interestingly, combined treatment induced a cell cycle arrest in G2/M phase for ~60% of cells...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27478441/precancerous-cervix-in-human-immunodeficiency-virus-infected-women-thirty-years-old-and-above-in-northern-uganda
#10
Jonathan Izudi, Norbert Adrawa, Dinah Amongin
Background. Little is known about precancerous cervical lesion (PCCL), the precursor of cervical cancer among Human Immunodeficiency (HIV) infected women in a postconflict setting of Northern Uganda. Objective. To establish factors associated with PCCL among HIV infected women above thirty years of age in a postconflict setting of Northern Uganda. Method. This retrospective cohort study used electronic data from 995 HIV-positive women that attended cervical cancer screening during June 2014 and December 2015...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27446211/clinical-performance-and-management-outcomes-with-the-decisiondx-um-gene-expression-profile-test-in-a-prospective-multicenter-study
#11
Kristen Meldi Plasseraud, Robert W Cook, Tony Tsai, Yevgeniy Shildkrot, Brooke Middlebrook, Derek Maetzold, Jeff Wilkinson, John Stone, Clare Johnson, Kristen Oelschlager, Thomas M Aaberg
Uveal melanoma management is challenging due to its metastatic propensity. DecisionDx-UM is a prospectively validated molecular test that interrogates primary tumor biology to provide objective information about metastatic potential that can be used in determining appropriate patient care. To evaluate the continued clinical validity and utility of DecisionDx-UM, beginning March 2010, 70 patients were enrolled in a prospective, multicenter, IRB-approved study to document patient management differences and clinical outcomes associated with low-risk Class 1 and high-risk Class 2 results indicated by DecisionDx-UM testing...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27429617/low-level-of-microsatellite-instability-correlates-with-poor-clinical-prognosis-in-stage-ii-colorectal-cancer-patients
#12
Ehsan Nazemalhosseini Mojarad, Seyed Mohammad Hossein Kashfi, Hanieh Mirtalebi, Mohammad Yaghoob Taleghani, Pedram Azimzadeh, Sanaz Savabkar, Mohammad Amin Pourhoseingholi, Hasan Jalaeikhoo, Hamid Asadzadeh Aghdaei, Peter J K Kuppen, Mohammad Reza Zali
The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC) requires more investigation. We assessed the role of MSI status in survival of individuals diagnosed with primary colorectal cancer. In this retrospective cross-sectional study the MSI status was determined in 158 formalin-fixed paraffin-embedded tumors and their matched normal tissues from patients who underwent curative surgery. Cox proportional hazard modeling was performed to assess the clinical prognostic significance...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27382369/changes-in-pathological-complete-response-rates-after-neoadjuvant-chemotherapy-for-breast-carcinoma-over-five-years
#13
Daniel C McFarland, Jessica Naikan, Mariya Rozenblit, John Mandeli, Ira Bleiweiss, Amy Tiersten
Historically, neoadjuvant chemotherapy (NACT) was extrapolated from adjuvant regimens. Dual HER2 blockade and the introduction of carboplatin for triple negative breast cancers (TNBC) emerged by December 2013 and have improved pathological complete response (pCR) rates. The objective of this study was to assess the pCR rates before and after the introduction of these new neoadjuvant regimens. Materials and Methods. Stage I-III breast cancer patients who received NACT were analyzed for rates of pCR by clinical characteristics (i...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27340404/clinicopathological-profile-of-pure-neuroendocrine-neoplasms-of-the-esophagus-a-south-indian-center-experience
#14
Govind Babu Kanakasetty, Loknatha Dasappa, Kuntegowdanahalli Chinnagiriyappa Lakshmaiah, Mangesh Kamath, Linu Abraham Jacob, Suresh Babu Mallekavu, Lakkavalli Krishnappa Rajeev, Rudresha Antapura Haleshappa, Lokesh Kadabur Nagendrappa, Smitha Carol Saldanha, Rekha V Kumar
Purpose. Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide. Studies on clinical profile, management, and outcomes are very uncommon. Methods. We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014. Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27313614/frequency-of-bcr-abl-transcript-types-in-syrian-cml-patients
#15
Sulaf Farhat-Maghribi, Wafa Habbal, Fawza Monem
Background. In Syria, CML patients are started on tyrosine kinase inhibitors (TKIs) and monitored until complete molecular response is achieved. BCR-ABL mRNA transcript type is not routinely identified, contrary to the recommendations. In this study we aimed to identify the frequency of different BCR-ABL transcripts in Syrian CML patients and highlight their significance on monitoring and treatment protocols. Methods. CML patients positive for BCR-ABL transcripts by quantitative RT-PCR were enrolled. BCR-ABL transcript types were investigated using a home-made PCR method that was adapted from published protocols and optimized...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27242900/curcumin-and-resveratrol-as-promising-natural-remedies-with-nanomedicine-approach-for-the-effective-treatment-of-triple-negative-breast-cancer
#16
REVIEW
Amol Shindikar, Akshita Singh, Malcolm Nobre, Saurabh Kirolikar
Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and genetic changes, its physiology, and its prognosis. This has allowed us to identify specific targets and design appropriate chemical entities for effective treatment of most breast cancer phenotypes, resulting in increased patient survivability. Unfortunately, these strategies have been largely ineffective in the treatment of triple negative breast cancer (TNBC)...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27239196/excisional-treatment-of-cervical-dysplasia-in-australia-2004-2013-a-population-based-study
#17
Gregory Robertson, Stephen J Robson
Background. Excisional treatment of preinvasive cervical dysplasia has been associated with adverse pregnancy outcomes. We aimed to examine trends in the rate of excisional treatment in reproductive age women in the era of HPV vaccination. Methods. National data for Australia regarding histological diagnoses of cervical dysplasia and excisional treatment for the period from 2004 to 2013 inclusive were obtained from two datasets and used to calculate age-stratified incidence rates of excisional treatment and of excisional treatments per diagnosis of dysplasia...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27066075/moving-beyond-karnofsky-and-ecog-performance-status-assessments-with-new-technologies
#18
REVIEW
Ciara M Kelly, Armin Shahrokni
Progress in cancer research is coupled with increased treatment complexity reliant upon accurate patient selection. Oncologists rely upon measurement instruments of functional performance such as the Karnofsky or Eastern Cooperative Oncology Group Performance Status scales that were developed over fifty years ago to determine a patient's suitability for systemic treatment. These standard assessment tools have been shown to correlate with response to chemotherapy, chemotherapy tolerability, survival, and quality of life of cancer patients...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27042179/correlation-of-beta-2-adrenergic-receptor-expression-in-tumor-free-surgical-margin-and-at-the-invasive-front-of-oral-squamous-cell-carcinoma
#19
Denise Tostes Oliveira, Diego Mauricio Bravo-Calderón, Gustavo Amaral Lauand, Agnes Assao, José-Manuel Suárez-Peñaranda, Mario Pérez-Sayáns, Abel García-García, Aparecido Nilceu Marana, Suely Nonogaki, José Roberto Pereira Lauris, Luiz Paulo Kowalski
Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (β2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with β2-AR expression was verified by the chi-square test or Fischer's exact test...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27034667/enchondroma-versus-chondrosarcoma-in-long-bones-of-appendicular-skeleton-clinical-and-radiological-criteria-a-follow-up
#20
Eugenio M Ferrer-Santacreu, Eduardo J Ortiz-Cruz, Mariana Díaz-Almirón, Jose Juan Pozo Kreilinger
As of today two types of cartilage tumors remain a challenge even for the orthopedic oncologist: enchondroma (E), a benign tumor, and chondrosarcoma (LGC), a malignant and low aggressiveness tumor. A prospective study of 133 patients with a cartilaginous tumor of low aggressiveness in the long bones of the appendicular skeleton was done to prove this difficult differential diagnosis. Parameters including medical history and radiological and nuclear imaging were collected and compared to the result of the biopsy...
2016: Journal of Oncology
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