journal
https://read.qxmd.com/read/38404132/regulation-of-colonic-neuropeptide-y-expression-by-the-gut-microbiome-in-patients-with-ulcerative-colitis-and-its-association-with-anxiety-and-depression-like-behavior-in-mice
#21
JOURNAL ARTICLE
Min-Kyung Joo, Jae-Won Lee, Jeong-Hwa Woo, Hyo-Jong Kim, Dong-Hyun Kim, Jung-Hye Choi
Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric disorders and the gut microbiota is unclear. This study aimed to examine whether gut microbiota from patients with UC can alter colonic gene expression, leading to anxiety- and depression-like behavior in mice receiving fecal microbiota transplantation (FMT). RNA sequencing transcriptome analyses revealed a difference in colonic gene expression between mice receiving FMT from patients with UC (UC-FMT mice) and those receiving FMT from healthy controls (HC-FMT mice)...
2024: Gut Microbes
https://read.qxmd.com/read/38404111/the-intestinal-microbiome-of-inflammatory-bowel-disease-across-the-pediatric-age-range
#22
JOURNAL ARTICLE
Máire A Conrad, Kyle Bittinger, Yue Ren, Kelly Kachelries, Jennifer Vales, Hongzhe Li, Gary D Wu, Frederic D Bushman, Marcella Devoto, Robert N Baldassano, Judith R Kelsen
Dysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. Here, we aimed to demonstrate the impact of age and inflammation on microbial community structure using shotgun metagenomic sequencing in children with VEO-IBD, pediatric-onset IBD, and age-matched pediatric healthy controls (HC) observed longitudinally over the course of 8 weeks. We found disease-related differences in alpha and beta diversity between HC and children with IBD or VEO-IBD...
2024: Gut Microbes
https://read.qxmd.com/read/38400752/chemotherapy-induced-microbiota-exacerbates-the-toxicity-of-chemotherapy-through-the-suppression-of-interleukin-10-from-macrophages
#23
JOURNAL ARTICLE
Zhen He, Hongyu Xie, Haoyang Xu, Jinjie Wu, Wanyi Zeng, Qilang He, Christian Jobin, Sanqing Jin, Ping Lan
The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeutic toxicity would have a profound impact on cancer management. In this study, we report that fecal microbiota transplantation from oxaliplatin-exposed mice promotes toxicity in recipient mice. Splenic RNA sequencing and macrophage depletion experiment showed that the microbiota-induced toxicity of oxaliplatin in mice was dependent on macrophages...
2024: Gut Microbes
https://read.qxmd.com/read/38400721/s-amlodipine-induces-liver-inflammation-and-dysfunction-through-the-alteration-of-intestinal-microbiome-in-a-rat-model
#24
JOURNAL ARTICLE
Xinxin Liu, Hui Fang, Liuzhu Pan, Peng Zhang, Huai Lin, Huihui Gao, Chaolin Ye, Daqing Mao, Yi Luo
S-amlodipine, a commonly prescribed antihypertensive agent, is widely used in clinical settings to treat hypertension. However, the potential adverse effects of long-term S-amlodipine treatment on the liver remain uncertain, given the cautionary recommendations from clinicians regarding its administration in individuals with impaired liver function. To address this, we conducted a study using an eight-week-old male rat model and administered a daily dose of 0.6 ~ 5 mg/kg of S-amlodipine for 7 weeks...
2024: Gut Microbes
https://read.qxmd.com/read/38391242/the-helicobacter-pylori-cag-pathogenicity-island-as-a-determinant-of-gastric-cancer-risk
#25
REVIEW
Sirena C Tran, Kaeli N Bryant, Timothy L Cover
Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island ( cag PAI). Colonization of the human stomach with cag PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with cag PAI-negative strains. The cag PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells...
2024: Gut Microbes
https://read.qxmd.com/read/38391178/-b-longum-ckd1-enhances-the-efficacy-of-anti-diabetic-medicines-through-upregulation-of-il-22-response-in-type-2-diabetic-mice
#26
JOURNAL ARTICLE
Won Jun Kim, Bum Ju Kil, Chaewon Lee, Tae Young Kim, Goeun Han, Yukyung Choi, Kyunghwan Kim, Chang Hun Shin, Seung-Young Park, Heebal Kim, Myunghoo Kim, Chul Sung Huh
The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining the effects of Bifidobacterium longum NBM7-1 (CKD1) with anti-diabetic medicines, LobeglitazoneⓇ (LO), SitagliptinⓇ (SI), and MetforminⓇ (Met), to alleviate hyperglycemia in a diabetic mouse model. CKD1 effectively mitigated insulin resistance, hepatic steatosis, and enhanced pancreatic β-cell function, as well as fortifying gut-tight junction integrity...
2024: Gut Microbes
https://read.qxmd.com/read/38385162/the-biotherapeutic-clostridium-butyricum-miyairi-588-strain-potentiates-enterotropism-of-ror%C3%AE-t-treg-and-pd-1-blockade-efficacy
#27
JOURNAL ARTICLE
Thomas Paz Del Socorro, Kentaro Oka, Olivier Boulard, Motomichi Takahashi, Lionel Franz Poulin, Atsushi Hayashi, Mathias Chamaillard
Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic association between supplementation with Clostridium butyricum MIYAIRI 588 (CBM588) and ICI efficacy in NSCLC. However, it remains to be established whether this biotherapeutic strain may be sufficient to heighten the immunogenicity of the tumor draining lymph nodes to overcome resistance to ICI. Herein, we report that supplementation with CBM588 led to an improved responsiveness to antibody targeting programmed cell death protein 1 (aPD-1)...
2024: Gut Microbes
https://read.qxmd.com/read/38381494/a-tailored-series-of-engineered-yeasts-for-the-cell-dependent-treatment-of-inflammatory-bowel-disease-by-rational-butyrate-supplementation
#28
JOURNAL ARTICLE
Jiahao Wu, He Huang, Lina Wang, Mengxue Gao, Shuxian Meng, Shaolan Zou, Yuanhang Feng, Zeling Feng, Zhixin Zhu, Xiaocang Cao, Bingzhi Li, Guangbo Kang
Intestinal microbiota dysbiosis and metabolic disruption are considered essential characteristics in inflammatory bowel disorders (IBD). Reasonable butyrate supplementation can help patients regulate intestinal flora structure and promote mucosal repair. Here, to restore microbiota homeostasis and butyrate levels in the patient's intestines, we modified the genome of Saccharomyces cerevisiae to produce butyrate. We precisely regulated the relevant metabolic pathways to enable the yeast to produce sufficient butyrate in the intestine with uneven oxygen distribution...
2024: Gut Microbes
https://read.qxmd.com/read/38375831/dietary-resistant-starch-supplementation-increases-gut-luminal-deoxycholic-acid-abundance-in-mice
#29
JOURNAL ARTICLE
Melanie A Reuter, Madelynn Tucker, Zara Marfori, Rahaf Shishani, Jessica Miranda Bustamante, Rosalinda Moreno, Michael L Goodson, Allison Ehrlich, Ameer Y Taha, Pamela J Lein, Nikhil Joshi, Ilana Brito, Blythe Durbin-Johnson, Renu Nandakumar, Bethany P Cummings
Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome. Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into secondary BAs, which can differentially regulate host health via signaling based on their varying affinity for BA receptors. Despite the importance of secondary BAs in host health, the regulation of 7-α-dehydroxylation and the role of diet in modulating this process is incompletely defined. Understanding this process could lead to dietary guidelines that beneficially shift BA metabolism...
2024: Gut Microbes
https://read.qxmd.com/read/38374654/colibactin-producing-escherichia-coli-enhance-resistance-to-chemotherapeutic-drugs-by-promoting-epithelial-to-mesenchymal-transition-and-cancer-stem-cell-emergence
#30
JOURNAL ARTICLE
Guillaume Dalmasso, Antony Cougnoux, Tiphanie Faïs, Virginie Bonnin, Benoit Mottet-Auselo, Hang Tt Nguyen, Pierre Sauvanet, Nicolas Barnich, Marine Jary, Denis Pezet, Julien Delmas, Richard Bonnet
Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senescence. Infected cells produce a senescence-associated secretory phenotype (SASP), which is involved in the increase in tumorigenesis observed in CRC mouse models infected with CoPEC. This study investigated whether CoPEC, and the SASP derived from CoPEC-infected cells, impacted chemotherapeutic resistance. Human intestinal epithelial cells were infected with the CoPEC clinical 11G5 strain or with its isogenic mutant, which is unable to produce colibactin...
2024: Gut Microbes
https://read.qxmd.com/read/38372783/probiotic-lactobacillus-spp-improves-drosophila-memory-by-increasing-lactate-dehydrogenase-levels-in-the-brain-mushroom-body-neurons
#31
JOURNAL ARTICLE
Shuk-Man Ho, Wan-Hua Tsai, Chih-Ho Lai, Meng-Hsuan Chiang, Wang-Po Lee, Hui-Yu Wu, Pei-Yi Bai, Tony Wu, Chia-Lin Wu
Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically Lactobacillus spp. are known probiotics. Drosophila melanogaster , commonly known as the fruit fly, is a well-established model organism for investigating the interaction between the host and gut microbiota in translational research...
2024: Gut Microbes
https://read.qxmd.com/read/38358253/gut-enterotype-dependent-modulation-of-gut-microbiota-and-their-metabolism-in-response-to-xanthohumol-supplementation-in-healthy-adults
#32
JOURNAL ARTICLE
Paige E Jamieson, Eli B Smart, John A Bouranis, Jaewoo Choi, Robert E Danczak, Carmen P Wong, Ines L Paraiso, Claudia S Maier, Emily Ho, Thomas J Sharpton, Thomas O Metz, Ryan Bradley, Jan F Stevens
Xanthohumol (XN), a polyphenol found in the hop plant ( Humulus lupulus ), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests the gut microbiome is essential in mediating these bioactivities; however, relatively little is known about XN's impact on human gut microbiota in vivo . We conducted a randomized, triple-blinded, placebo-controlled clinical trial (ClinicalTrials.gov NCT03735420) to determine safety and tolerability of XN in healthy adults. Thirty healthy participants were randomized to 24 mg/day XN or placebo for 8 weeks...
2024: Gut Microbes
https://read.qxmd.com/read/38356294/-salmonella-enterica-serovar-typhimurium-remodels-mitochondrial-dynamics-of-macrophages-via-the-t3ss-effector-sipa-to-promote-intracellular-proliferation
#33
JOURNAL ARTICLE
Xingmei Liu, Yutao Liu, Xinyu Zhao, Xueping Li, Ting Yao, Ruiying Liu, Qian Wang, Qiushi Wang, Dan Li, Xintong Chen, Bin Liu, Lu Feng
Mitochondrial dynamics are critical in cellular energy production, metabolism, apoptosis, and immune responses. Pathogenic bacteria have evolved sophisticated mechanisms to manipulate host cells' mitochondrial functions, facilitating their proliferation and dissemination. Salmonella enterica serovar Typhimurium ( S . Tm), an intracellular foodborne pathogen, causes diarrhea and exploits host macrophages for survival and replication. However, S . Tm-associated mitochondrial dynamics during macrophage infection remain poorly understood...
2024: Gut Microbes
https://read.qxmd.com/read/38356283/from-a-hunger-regulating-hormone-to-an-antimicrobial-peptide-gastrointestinal-derived-circulating-endocrine-hormone-peptide-yy-exerts-exocrine-antimicrobial-effects-against-selective-gut-microbiota
#34
JOURNAL ARTICLE
https://read.qxmd.com/read/38353638/gut-microbiota-regulates-host-melatonin-production-through-epithelial-cell-myd88
#35
JOURNAL ARTICLE
Bingnan Liu, Lijuan Fan, Youxia Wang, Hao Wang, Yuqi Yan, Shuai Chen, Ifen Hung, Chunxue Liu, Hong Wei, Liangpeng Ge, Wenkai Ren
Melatonin has various physiological effects, such as the maintenance of circadian rhythms, anti-inflammatory functions, and regulation of intestinal barriers. The regulatory functions of melatonin in gut microbiota remodeling have also been well clarified; however, the role of gut microbiota in regulating host melatonin production remains poorly understood. To address this, we studied the contribution of gut microbiota to host melatonin production using gut microbiota-perturbed models. We demonstrated that antibiotic-treated and germ-free mice possessed diminished melatonin levels in the serum and elevated melatonin levels in the colon...
2024: Gut Microbes
https://read.qxmd.com/read/38351748/gut-microbiota-derived-trimethylamine-n-oxide-a-novel-target-for-the-treatment-of-preeclampsia
#36
JOURNAL ARTICLE
Jiayi Wang, Yajie Gao, Shuaijun Ren, Jialin Li, Siqian Chen, Jiating Feng, Bing He, Yuping Zhou, Rongrong Xuan
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE. Trimethylamine N-oxide (TMAO) is an intestinal microbiota-derived metabolite that is thought to be involved in the occurrence of PE; however, its causal relationship and mechanism remain unclear. In this clinical cohort study, including 28 patients with eclampsia and 39 matched healthy controls, fecal samples were collected for 16S rRNA gene sequencing, and serum was collected for targeted metabolomics research...
2024: Gut Microbes
https://read.qxmd.com/read/38334087/-weizmannia-coagulans-bcf-01-a-novel-gastrogenic-probiotic-for-helicobacter-pylori-infection-control
#37
JOURNAL ARTICLE
Zhenhui Chen, Ziyu Tang, Wendan Li, Xiaoshi Deng, Lu Yu, Jixiang Yang, Jiaxin Liu, Yunshui Cheng, Wanwen Huang, Xiaotong Guo, Jiamin Shan, Daixuan Zhou, Weisen Zeng, Yang Bai, Hongying Fan
The widespread prevalence of Helicobacter pylori infection, particularly in China, contributes to the development of gastrointestinal diseases. Antibiotics have limitations, including adverse reactions and increased antibiotic resistance. Therefore, identification of novel gastrogenic probiotics capable of surviving the acidic gastric environment and effectively combating H. pylori infection has potential in restoring gastric microbiota homeostasis. Five novel strains of human gastrogenic Weizmannia coagulans (BCF-01-05) were isolated from healthy gastric mucosa and characterized using 16S rDNA identification...
2024: Gut Microbes
https://read.qxmd.com/read/38332701/vancomycin-relieves-tacrolimus-induced-hyperglycemia-by-eliminating-gut-bacterial-beta-glucuronidase-enzyme-activity
#38
JOURNAL ARTICLE
Peixia Li, Rui Zhang, Jinping Zhou, Pengpeng Guo, Yani Liu, Shaojun Shi
Up to 40% of transplant recipients treated long-term with tacrolimus (TAC) develop post-transplant diabetes mellitus (PTDM). TAC is an important risk factor for PTDM, but is also essential for immunosuppression after transplantation. Long-term TAC treatment alters the gut microbiome, but the mechanisms of TAC-induced gut microbiota in the pathogenesis of PTDM are poorly characterized. Here, we showed that vancomycin, an inhibitor of bacterial beta-glucuronidase (GUS), prevents TAC-induced glucose disorder and insulin resistance in mice...
2024: Gut Microbes
https://read.qxmd.com/read/38332676/repeated-s-ketamine-administration-ameliorates-the-spatial-working-memory-impairment-in-mice-with-chronic-pain-role-of-the-gut-microbiota-brain-axis
#39
JOURNAL ARTICLE
Yubin Jiang, Xingming Wang, Jiawei Chen, Yibao Zhang, Kenji Hashimoto, Jian-Jun Yang, Zhiqiang Zhou
Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic ( S )-ketamine on spatial working memory in a chronic constriction injury (CCI) mouse model, focusing on gut microbiome. We found that multiple doses of ( S )-ketamine, unlike a single dose, counteracted the reduced spontaneous alteration percentage (%SA) in the Y-maze spatial working memory test, without affecting mechanical or thermal pain sensitivity. Additionally, repeated ( S )-ketamine treatments improved the abnormal composition of the gut microbiome (β-diversity), as indicated by fecal 16S rRNA analysis, and increased levels of butyrate, a key gut - brain axis mediator...
2024: Gut Microbes
https://read.qxmd.com/read/38332500/the-ibs-bug-pain-connection
#40
JOURNAL ARTICLE
Elena F Verdu, Stephen Vanner
No abstract text is available yet for this article.
2024: Gut Microbes
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