Paige E Jamieson, Eli B Smart, John A Bouranis, Jaewoo Choi, Robert E Danczak, Carmen P Wong, Ines L Paraiso, Claudia S Maier, Emily Ho, Thomas J Sharpton, Thomas O Metz, Ryan Bradley, Jan F Stevens
Xanthohumol (XN), a polyphenol found in the hop plant ( Humulus lupulus ), has antioxidant, anti-inflammatory, prebiotic, and anti-hyperlipidemic activity. Preclinical evidence suggests the gut microbiome is essential in mediating these bioactivities; however, relatively little is known about XN's impact on human gut microbiota in vivo . We conducted a randomized, triple-blinded, placebo-controlled clinical trial (ClinicalTrials.gov NCT03735420) to determine safety and tolerability of XN in healthy adults. Thirty healthy participants were randomized to 24 mg/day XN or placebo for 8 weeks...
2024: Gut Microbes